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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

XCL1 Gene

protein-coding GIFtS: 59
GCID: GC01P168545

chemokine (C motif) ligand 1

(Previous names: small inducible cytokine subfamily C, member 1 (lymphotactin)...)
(Previous symbols: LTN, SCYC1)

Explore 32 diseases affiliated with
XCL1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chemokine (C Motif) Ligand 1¹ ²		Cytokine SCM-1² ³
LTN¹ ² ³ ⁵		Small-Inducible Cytokine C1² ³
SCYC1¹ ² ³ ⁵		SCM-1-Alpha¹
ATAC¹ ² ³		XC Chemokine Ligand 1² ³
LPTN¹ ² ⁵		SCM1² ⁵
SCM-1¹ ²		SCM1A²
SCM-1a¹ ²		Lymphotaxin³
Lymphotactin¹		Single Cysteine Motif 1a²
Small Inducible Cytokine Subfamily C, Member 1 (Lymphotactin)¹ ²		Lymphotaxin³
C Motif Chemokine 1² ³

External Ids:	HGNC: 10645¹	Entrez Gene: 6375²	Ensembl: ENSG00000143184⁷	OMIM: 600250⁵	UniProtKB: P47992³

Export aliases for XCL1 gene to outside databases

Previous GC identifers: GC01P166180 GC01P164196 GC01P165241 GC01P165733 GC01P165277 GC01P166812 GC01P139791

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for XCL1:

This gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological

responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily,

retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for

T cells. This gene and a closely related family member are located on the long arm of chromosome 1. (provided by

RefSeq, Nov 2010)

UniProtKB/Swiss-Prot: XCL1_HUMAN, P47992

Function: Chemotactic activity for lymphocytes but not for monocytes or neutrophils

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the XCL1 gene promoter:
FOXI1 HFH-3 C/EBPbeta AML1a NRSF form 1 STAT3 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 NRSF form 2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: XCL1 promoter sequence

Search SABiosciences Chromatin IP Primers for XCL1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XCL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23 Ensembl cytogenetic band: 1q24.2 HGNC cytogenetic band: 1q24.2

XCL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XCL1 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P168545: view genomic region (about GC identifiers)

Start:	168,545,711 bp from pter	End:	168,551,315 bp from pter
Size:	5,605 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: XCL1_HUMAN, P47992 (See protein sequence)

Recommended Name: Lymphotactin precursor

Size: 114 amino acids; 12517 Da

Subcellular location: Secreted

5 PDB 3D structures from and Proteopedia for XCL1:

1J8I (3D)

1J9O (3D)

2HDM (3D)

2JP1 (3D)

2NYZ (3D)

Secondary accessions: Q52MA8

Explore the universe of human proteins at neXtProt for XCL1: NX_P47992

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P47992

XCL1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002986.1

ENSEMBL proteins:

ENSP00000356792

Reactome Protein details: P47992
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for XCL1 (XCL1/Lymphotactin)
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	GenScript Purified and Recombinant Proteins for XCL1
	Novus Biologicals XCL1 Proteins Novus Biologicals XCL1 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for XCL1
	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	ISS	--

XCL1 for ontologies About GeneDecksing

XCL1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	GenScript Superior Antibodies for XCL1
	Novus Biologicals XCL1 Antibodies
	Search for Antibodies for XCL1 at Abcam
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for XCL1

Assay Products for XCL1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for XCL1
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

XCL1 for domains About GeneDecksing

2 InterPro domains/families:

IPR001811 Chemokine_IL8-like_dom

IPR008105 Chemokine_XCL1

Graphical View of Domain Structure for InterPro Entry P47992

ProtoNet protein and cluster: P47992

1 Blocks protein family: IPB008105 Lymphotactin precursor signature

UniProtKB/Swiss-Prot: XCL1_HUMAN, P47992

Similarity: Belongs to the intercrine gamma family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: XCL1_HUMAN, P47992

Function: Chemotactic activity for lymphocytes but not for monocytes or neutrophils

miRNA Products:		OriGene 3'-UTR Clone: XCL1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat XCL1
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate XCL1
		SwitchGear 3'UTR luciferase reporter plasmid: XCL1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for XCL1 (see all 7) OriGene shRNA RFP: XCL1 OriGene siRNA: XCL1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XCL1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for XCL1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XCL1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XCL1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: XCL1 (NM_001511)
		Sino Biological Human cDNA Clone for XCL1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for XCL1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XCL1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for XCL1
		Search LifeMap BioReagents cell lines for XCL1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XCL1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008009	chemokine activity	IDA	7602097
GO:0042379	chemokine receptor binding	NAS	7602097
GO:0042803	protein homodimerization activity	IDA	11889129

XCL1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for XCL1:

Decreased viability

Animal Models:
Mouse knock-outs for XCL1: Xcl1^tm1.1Dnax Xcl1^tm1Rakr
7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Xcl1):

cardiovascular system	digestive/alimentary	endocrine/exocrine gland	hematopoietic system	immune system
liver/biliary system	vision/eye

XCL1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			Peptide ligand-binding receptors	0.61
	GPCR ligand binding	0.75

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Cell adhesion_Cell-matrix glycoconjugates

Cell adhesion_Cell-matrix glycoconjugates

1.00

Cell adhesion Cell-matrix glycoconjugates

0.97

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Chemokine Signaling

Chemokine Signaling

1.00

Chemokine signaling pathway

0.33

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for XCL1

Cell adhesion Cell-matrix glycoconjugates

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for XCL1

	Chemokine Signaling
	Transendothelial Migration of Leukocytes

1 GeneGo (Thomson Reuters) Pathway for XCL1

Cell adhesion Cell-matrix glycoconjugates

5/9 Reactome Pathways for XCL1 (see all 9)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	GPCR ligand binding

2 Kegg Pathways (Kegg details for XCL1):

	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway

XCL1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for XCL1

STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

5/19 Interacting proteins for XCL1 (P47992³ ENSP00000356792⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 19)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
VCAN	P13611³, ENSP00000265077⁴	I2D: score=1 STRING: ENSP00000265077
XCR1	P46094³, ENSP00000310405⁴	I2D: score=1 STRING: ENSP00000310405
CCR1	ENSP00000296140⁴	STRING: ENSP00000296140
CCR10	ENSP00000332504⁴	STRING: ENSP00000332504
CCR2	ENSP00000292301⁴	STRING: ENSP00000292301

About this table

Gene Ontology (GO): 5/36 biological process terms (GO ID links to tree view) (see all 36): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001916	positive regulation of T cell mediated cytotoxicity	IDA	18832695
GO:0002690	positive regulation of leukocyte chemotaxis	ISS	--
GO:0002725	negative regulation of T cell cytokine production	IDA	10887101
GO:0002726	positive regulation of T cell cytokine production	ISS	--
GO:0002826	negative regulation of T-helper 1 type immune response	IC	10887101

XCL1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

XCL1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for XCL1
10/11 Novoseek chemical compound relationships for XCL1 gene (see all 11) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rantes	84.4	33	9393669 (1), 10942204 (1), 14734774 (1), 19397398 (1) (see all 29)
ccl3	54.3	4	14734774 (1), 18179747 (1)
ccl4	28.9	5	14734774 (1), 12427307 (1), 18179747 (1)
cysteine	19.3	7	9393669 (1), 9632725 (1), 8977329 (1), 7602097 (1) (see all 5)
wortmannin	15.4	2	10887101 (1), 10092776 (1)
cyclosporin a	14.6	4	12393716 (1), 7615002 (1), 11696436 (1)
heparin	6.63	4	14707146 (2), 19480914 (1), 9079718 (1)
tacrolimus	3.26	1	11696436 (1)
nacl	0	1	17302442 (1)
calcium	0	5	9271361 (2), 7615002 (2), 7602097 (1)

Search CenterWatch for drugs/clinical trials and news about XCL1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for XCL1 gene:

NM_002995.2

Unigene Cluster for XCL1:

Chemokine (C motif) ligand 1

Hs.546295 [show with all ESTs]

Unigene Representative Sequence: NM_002995

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000367818(uc001gfo.2)

miRNA Products:		OriGene 3'-UTR Clone: XCL1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat XCL1
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate XCL1
		SwitchGear 3'UTR luciferase reporter plasmid: XCL1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for XCL1 (see all 7) OriGene shRNA RFP: XCL1 OriGene siRNA: XCL1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XCL1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XCL1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XCL1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: XCL1 (NM_001511)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for XCL1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XCL1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XCL1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat XCL1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XCL1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XCL1

Additional cDNA sequence:

BC069817.1 BC070309.1 D43768.1 U23772.1 X86474.1

3 DOTS entries:

DT.109036 DT.100735017 DT.91854396

23 AceView cDNA sequences:

BE348632 D43768 BX282187 AW134570 AI969003 BF433809 NM_002995 AI669817

AI298976 BQ005208 CD522000 AW050650 BV198119 U23772 X86474 BE466930

BC070309 AI651995 AW050525 CB120610 CD639746 BG214157 AA650495

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

XCL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

XCL1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Bone marrow-derived mesenchymal stem cells (Stempeucel) (Adult Stem / Progenitor Cell)

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See XCL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for XCL1

SOURCE GeneReport for Unigene cluster: Hs.546295

UniProtKB/Swiss-Prot: XCL1_HUMAN, P47992

Tissue specificity: Highest level in spleen, lower in peripheral leukocytes and very low levels in lung, colon and

small intestine

SABiosciences Expression via Pathway-Focused PCR Arrays including XCL1:

HIV Host Response in human mouse rat

Cytokines & Chemokines in human mouse rat

Inflammatory Response & Autoimmunity 384HT in human mouse rat

Chemokines & Receptors in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XCL1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat XCL1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XCL1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XCL1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XCL1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for XCL1 gene from 2/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Xcl1^{1 , 5}	chemokine (C motif) ligand 1^{1, 5}	73.39(n)¹ 60.53(a)¹		1 (72.26 cM)⁵ 16963¹ NM_008510.1¹ NP_032536.1¹ 164931644⁵
chicken (Gallus gallus)	Aves	LOC395914⁶	lymphotactin	33(a)	1 → many	1(87329807-87334160)

ENSEMBL Gene Tree for XCL1 (if available)
TreeFam Gene Tree for XCL1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for XCL1 gene

XCL2²

15 SIMAP similar genes for XCL1 using alignment to 1 protein entry: XCL1_HUMAN:

XCL2 CCL8 CCL13 CCL11 CCL14 CCL3L1

CCL3L3 CCL26 CCL24 CCL4L1 CCL4L2 LOC728835

CCL5 CCL7 MCP-3

XCL1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs187752081^1,2		--	168543718(+)	`GGAGAA/CGCAGG`	1	--	us2k¹		0	--	--	--	--
rs470739^1,2	F,O,A,	--	168543747(-)	`CTCATG/TGTGTT`	1	--	us2k¹		2		WA NA	238
rs4304552^1,2	C,F,A,H,	--	168543756(+)	`AGATTC/AGTTGC`	1	--	us2k¹		12		NS EA NA	1476
rs201863006^1,2		--	168543846(+)	`GAAAA-/CTTATA`	1	--	us2k¹		0	--	--	--	--
rs193141326^1,2		--	168543907(+)	`CCAGTC/TAAAGG`	1	--	us2k¹		0	--	--	--	--
rs140635581^1,2		--	168544060(+)	`ATCACA/TGTGAA`	1	--	us2k¹		0	--	--	--	--
rs182772388^1,2		--	168544062(+)	`CACAGC/TGAAAG`	1	--	us2k¹		0	--	--	--	--
rs552568^1,2	A	--	168544083(+)	`catccC/Tatagg`	1	--	us2k¹		2		NA	4
rs34038445^1,2	C,	--	168544084(+)	`ATCCCG/ATAGGC`	1	--	us2k¹		7		NA WA CSA EA	365
rs187507797^1,2		--	168544144(+)	`GAGGCA/TTTACA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for XCL1 (168545711 - 168551315 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for XCL1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XCL1

DNA2.0 Custom Variant and Variant Library Synthesis for XCL1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

XCL1 for disorders           About GeneDecksing

OMIM gene information: 600250    OMIM disorders: --

20/32 diseases for XCL1 (see all 32):    About MalaCards

wegener's granulomatosis dacryoadenitis t-lymphocytopenia rheumatoid arthritis

chronic lymphocytic leukemia allergic asthma lymphocytic leukemia essential hypertension

multiple sclerosis renal tuberculosis crohn's disease myocarditis

hepatitis b arthritis asthma pertussis

hypertension hepatocellular carcinoma t-cell leukemia leukemia

1 disease from the University of Copenhagen DISEASES database for XCL1:

Renal tuberculosis

5 Novoseek disease relationships for XCL1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	26.7	3	19797511 (1), 9013979 (1), 11696436 (1)
rheumatoid arthritis	2.62	4	12847680 (2)
necrosis	0	1	15614041 (1)
tumors	0	4	12406881 (1), 17397028 (1), 15614041 (1), 17471169 (1)
cancer	0	3	15547752 (1), 20225245 (1)

Human Genome Epidemiology (HuGE) Navigator: XCL1 (5 documents)

Export disorders for XCL1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for XCL1 gene, integrated from 9 sources (see all 126):
(articles sorted by number of sources associating them with XCL1)

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Molecular cloning of a novel C or gamma type chemokine, SCM-1. (PubMed id 7875320)^{1, 2, 3, 9} Yoshida T.... Yoshie O. (1995)
Molecular cloning and functional characterization of human lymphotactin. (PubMed id 7602097)^{1, 2, 3, 9} Kennedy J.... Zlotnik A. (1995)
Cloning of ATAC, an activation-induced, chemokine-related molecule exclusively expressed in CD8+ T lymphocytes. (PubMed id 7615002)^{1, 2, 9} Mueller S.... Kroczek R.A. (1995)
Monomeric solution structure of the prototypical 'C' chemokine lymphotactin. (PubMed id 11601972)^{1, 2, 9} Kuloglu E.S....Volkman B.F. (2001)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Structure and expression of two highly related genes encoding SCM- 1/human lymphotactin. (PubMed id 8849694)^{1, 2} Yoshida T....Yoshie O. (1996)
CD8+ alpha beta+ T cells that lack surface CD5 antigen expression are a major lymphotactin (XCL1) source in peripheral blood lymphocytes. (PubMed id 14568926)^{1, 9} Stievano L....Amadori A. (2003)
Expression and function of the C-class chemokine lymp hotactin (XCL1) in Wegener's granulomatosis. (PubMed id 19797511)^{1, 9} Blaschke S....MA1ller G.A. (2009)
The C-class chemokine, lymphotactin, impairs the induction of Th1-type lymphokines in human CD4(+) T cells. (PubMed id 10887101)^{1, 9} Cerdan C....Olive D. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6375	HGNC: 10645	AceView: XCL1	Ensembl:ENSG00000143184	euGenes: HUgn6375
ECgene: XCL1	Kegg: 6375	H-InvDB: XCL1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for XCL1	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/XCL1

Intellectual Property for XCL1 gene
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Patent Information for XCL1 gene:
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XCL1 Gene

chemokine (C motif) ligand 1

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XCL1 (Gene Symbol)
Chemokine (C Motif) Ligand 1
LTN
SCYC1
ATAC
LPTN
SCM-1
SCM-1a
Lymphotactin
Small Inducible Cytokine Subfamily C, Member 1 (Lymphotactin)
C Motif Chemokine 1
Cytokine SCM-1
Small-Inducible Cytokine C1
SCM-1-Alpha
XC Chemokine Ligand 1
SCM1
SCM1A
Lymphotaxin
Single Cysteine Motif 1a
Lymphotaxin

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XCL1 Gene

chemokine (C motif) ligand 1

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