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Aliases & Descriptions for XCL1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases ATAC 1 , 2 , 3 LPTN 1 , 2 , 5 LTN 2 , 3 , 5 Lymphotaxin 3 OTTHUMP00000032498 2 OTTHUMP00000060404 2 SCM-1 1 , 2 SCM-1-alpha 3 SCM-1a 1 , 2 SCM1 2 , 5 SCYC1 2 , 3 , 5 lymphotactin 1 , 2
Descriptions C motif chemokine 1 3 Cytokine SCM-1 3 Small-inducible cytokine C1 3 XC chemokine ligand 1 3 chemokine (C motif) ligand 1 2 small inducible cytokine subfamily C, member 1 (lymphotactin) 1 , 2
Search outside databases for aliases for XCL1 genePrevious GC identifers: GC01P166180 GC01P164196 GC01P165241 GC01P165733 GC01P165277
Summaries for XCL1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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UniProtKB/Swiss-Prot: XCL1_HUMAN, P47992 Function : Chemotactic activity for lymphocytes but not for monocytes or neutrophils
Genomic Location for XCL1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
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Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the XCL1 gene Entrez Gene cytogenetic band: 1q23 Ensembl cytogenetic band: 1q24.2 HGNC cytogenetic band: 1q24.2 XCL1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P166812:
(about GC identifiers )
Start:
166,812,480 bp from pter
End:
166,817,939 bp from pter
Size:
5,460 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000001.9 NT_004487.18 Proteins for XCL1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: XCL1_HUMAN, P47992 (See
protein sequence )Recommended Name: Lymphotactin precursor Size : 114 amino acids; 12517 Da
Subcellular location : Secreted
PDB structures from and Proteopedia : 1J8I (3D)
 1J9O (3D)
 2HDM (3D)
 2JP1 (3D)
 2NYZ (3D)
 
Secondary accessions : Q52MA8
REFSEQ proteins: NP_002986.1 ENSEMBL proteins: ENSP00000356792 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005576 extracellular region
IEA -- GO:0005615 extracellular space
IEA --
About this table Antibodies for XCL1: Assays for XCL1:
Protein
Domains/ Families for XCL1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P47992 ProtoNet protein and cluster: P47992
1 Blocks protein family : IPB008105 Lymphotactin precursor signature UniProtKB/Swiss-Prot: XCL1_HUMAN, P47992 Similarity : Belongs to the intercrine gamma family
Gene Function for XCL1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002995 Applied Biosystems Silencer ® siRNAs for XCL1 Sigma-Aldrich siRNA for XCL1 Sigma-Aldrich shRNA Panels and shRNA for XCL1 Explore Sigma-Aldrich super-pooled esiRNAs               OriGene GFP tagged cDNA clone in CMV expression vector: NM_002995                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002995                                  untagged cDNA clone in CMV expression vector: NM_002995  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_002995 UniProtKB/Swiss-Prot: XCL1_HUMAN, P47992 Function : Chemotactic activity for lymphocytes but not for monocytes or neutrophils
1 Gene Ontology (GO) molecular function term (links to tree view) :
About this table
Pathways & Interactions for XCL1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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5/36 Interacting proteins for XCL1 (ENSP00000356792 3 ) via UniProtKB, MINT, and/or STRING (see all 36
)About this table 5 Gene Ontology (GO) biological process terms (links to tree view) :
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Drugs & Compounds for XCL1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for XCL1 6 Novoseek chemical compound relationships for XCL1 gene
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Transcripts for XCL1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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siRNAs from Applied Biosystems ,
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shRNA from
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002995 Sigma-Aldrich siRNA for XCL1 Sigma-Aldrich shRNA Panels and shRNA for XCL1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_002995
REFSEQ mRNAs for XCL1 gene: NM_002995.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002995
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002995                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002995                                  untagged cDNA clone in CMV expression vector: NM_002995  
Additional cDNA sequence: BC069817.1 BC070309.1 D43768.1 U23772.1 X86474.1
3 DOTS entries : DT.109036 DT.100735017 DT.91854396
23 AceView cDNA sequences :BE348632 AW134570 AI669817 BX282187 NM_002995 BF433809 D43768 AI969003 CD522000 AI298976 U23772 X86474 BQ005208 BE466930 BV198119 AW050650 BC070309 AI651995 AW050525 CB120610 CD639746 AA650495 BG214157
highest scoring ESTs for XCL1 :BC069817 BG214157 BQ005208 AA864918 AI094359 AI929309 AL031736 BG057735 BG436992 AI298976
Unigene Cluster for XCL1: Chemokine (C motif) ligand 1 Hs.546295 [show with all ESTs ] Unigene Representative Sequence: NM_002995 GeneLoc Exon Structure 1 Ensembl transcript including schematic representation : ENST00000367818
Expression for XCL1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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XCL1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for XCL1 1 / 2 / 3
8 probe-sets matching XCL1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.546295 Expression variation in blood from EXPOLDB for XCL1
UniProtKB/Swiss-Prot: XCL1_HUMAN, P47992 Tissue specificity : Highest level in spleen, lower in peripheral leukocytes and very low levels inlung, colon and small intestine
Orthologs for XCL1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for XCL1 gene from 3 species
About this table Species with no ortholog for XCL1 ENSEMBL Gene Tree for XCL1 Paralogs for XCL1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for XCL1 gene XCL2 2
SNPs/Variants for XCL1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for XCL1 (up to first 250kb)
Disorders & Mutations for XCL1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 600250 5 Novoseek disease relationships for XCL1 gene
About this table Human Genome Epidemiology Navigator: XCL1 (2 documents)
Medical News for XCL1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for XCL1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/117 PubMed articles for XCL1 gene (see all 117
): Molecular cloning of a novel C or gamma type chemokine, SCM-1. (PubMed id 7875320) 1, 2, 3, 4 Yoshida T....Yoshie O. (1995) Molecular cloning and functional characterization of human lymphotactin. (PubMed id 7602097) 1, 2, 3, 4 Kennedy J.... Zlotnik A. (1995) Cloning of ATAC, an activation-induced, chemokine-related molecule exclusively expressed in CD8+ T lymphocytes. (PubMed id 7615002) 1, 3, 4 Mueller S.... Kroczek R.A. (1995) Monomeric solution structure of the prototypical 'C' chemokine lymphotactin. (PubMed id 11601972) 1, 3, 4 Kuloglu E.S....Volkman B.F. (2001) Structure and expression of two highly related genes encoding SCM- 1/human lymphotactin. (PubMed id 8849694) 1, 3, 4 Yoshida T....Yoshie O. (1996) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 3, 4 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) CD8+ alpha beta+ T cells that lack surface CD5 antigen expression are a major lymphotactin (XCL1) source in peripheral blood lymphocytes. (PubMed id 14568926) 1, 3 Stievano L....Amadori A. (2003) The C-class chemokine, lymphotactin, impairs the induction of Th1-type lymphokines in human CD4(+) T cells. (PubMed id 10887101) 1, 3 Cerdan C....Olive D. (2000) Purification, structural analysis, and function of natural ATAC, a cytokine secreted by CD8(+) T cells. (PubMed id 9079718) 1, 3 Dorner B....Kroczek R.A. (1997)
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Genome Databases showing XCL1
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euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing XCL1
(According to HUGE )
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--
Specialized Databases showing XCL1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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Name Description
Wikipedia http://en.wikipedia.org/wiki/XCL1
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-- Services for XCL1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for XCL1:
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