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XBP1 Gene

protein-coding GIFtS: 66

GC22M027515

X-box binding protein 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: XBP2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
OTTHUMP00000028682 ^²
TREB5 ^², ³
XBP-1 ^³
XBP2 ^², ³, ⁵

Descriptions
Tax-responsive element-binding protein 5 ^³
X-box binding protein 1 ^²
X-box-binding protein-1 ^²

External Ids
HGNC: 12801¹
Entrez Gene: 7494²
UniProtKB: P17861³
Ensembl: ENSG00000100219⁷

Search outside databases for aliases for XBP1 gene

Previous GC identifer: GC22M025886

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for XBP1:

This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter

element referred to as an X box. This gene product is a bZIP protein, which was also identified as

a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia

virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding

partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins

in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an

unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1

(IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform

XBP1(S), which is the functionally active transcription factor. The isoform encoded by the

unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative

feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery

phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.

[provided by RefSeq]

UniProtKB/Swiss-Prot: XBP1_HUMAN, P17861

Function: Transcription factor essential for hepatocyte growth, the differentiation of plasma

cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during

endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via

direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element

5'-GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA

DR-alpha promoter. Binds to the Tax-responsive element (TRE) of HTLV-I

Gene Wiki entry for XBP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the XBP1 gene

Entrez Gene cytogenetic band: 22q12.1|22q12 Ensembl cytogenetic band: 22q12.1 HGNC cytogenetic band: 22q12.1

XBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22M027515: (about GC identifiers)

Start:	27,520,545 bp from pter
End:	27,526,560 bp from pter
Size:	6,016 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000022.9 NT_011520.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: XBP1_HUMAN, P17861 (See protein sequence)

Recommended Name: X-box-binding protein 1

Size: 261 amino acids; 28695 Da

Subcellular location: Nucleus

Secondary accessions: Q8WYK6 Q969P1 Q96BD7

Alternative splicing: 2 isoforms: P17861-1 P17861-2

REFSEQ proteins (2 alternative transcripts):

NP_001073007.1 NP_005071.2

ENSEMBL proteins:

ENSP00000384295 ENSP00000385162 ENSP00000343155 ENSP00000216037

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (XBP1)
	Human Recombinant Proteins from Abnova (XBP1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

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Antibodies for XBP1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for XBP1
	R&D Systems Antibodies for XBP1
	Antibodies from Abcam (XBP1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (XBP1)
	Novus Biologicals Antibodies for XBP1

Assays for XBP1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P17861

ProtoNet protein and cluster: P17861

UniProtKB/Swiss-Prot: XBP1_HUMAN, P17861

Similarity: Belongs to the bZIP family

Similarity: Contains 1 bZIP domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XBP1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (XBP1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001079539

Applied Biosystems Silencer® siRNAs for XBP1

Sigma-Aldrich siRNA for XBP1

Sigma-Aldrich shRNA for XBP1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for XBP1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001079539
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001079539
untagged cDNA clones in CMV expression vector (see all 3): NM_001079539

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001079539

UniProtKB/Swiss-Prot: XBP1_HUMAN, P17861

Function: Transcription factor essential for hepatocyte growth, the differentiation of plasma

cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during

endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via

direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element

5'-GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA

DR-alpha promoter. Binds to the Tax-responsive element (TRE) of HTLV-I

Induction: Up-regulated by ATF6 via direct binding to the ERSE in response to endoplasmic reticulum

stress

Genatlas biochemistry entry for XBP1:

X-box protein 1,binding HLA-DRA,HLA-DRB promoter

14 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Xbp1):

	behavior/neurological	cellular	embryogenesis	growth/size
hematopoietic system	homeostasis/metabolism	immune system	lethality-prenatal/perinatal	life span-post-weaning/aging
liver/biliary system	muscle	nervous system	skin/coat/nails

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	TAS	1718857 2321018
GO:0043565	sequence-specific DNA binding	IEA	--
GO:0046983	protein dimerization activity	IEA	--

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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for XBP1 (Your Favorite Gene powered by Ingenuity)

Endoplasmic Reticulum Stress Pathway

GeneDecks XBP1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for XBP1

5/28 Interacting proteins for XBP1 (P17861² ENSP00000343155³) via UniProtKB, MINT, and/or STRING (see all 28 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
XBP1	P17861²	MINT-19434
ESR1	ENSP00000206249³	STRING (score=.997)
FOXA1	ENSP00000250448³	STRING (score=.968)
EDEM1	ENSP00000256497³	STRING (score=.934)
PRDM1	ENSP00000071246³	STRING (score=.915)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006955	immune response	TAS	1718857

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for XBP1
9 Novoseek chemical compound relationships for XBP1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
2-methoxyestradiol	53.62	3	17257674 (2)
leucine	26.56	3	7608116 (1), 18287238 (1), 15936220 (1)
lithium	17.10	3	15927087 (2), 15836800 (1)
phosphoinositide	11.43	1	19412428 (1)
phospholipid	0.00	1	15466483 (1)
lipid	0.00	3	15466483 (1), 19106412 (1)
glucose	0.00	10	17906960 (2), 16950141 (1), 17526500 (1), 19079611 (1) (see all 5)
calcium	0.00	3	15380296 (2), 17217928 (1)
cyclic amp	0.00	1	15936220 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (XBP1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (XBP1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001079539

Sigma-Aldrich siRNA for XBP1

Sigma-Aldrich shRNA for XBP1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001079539 NM_005080

REFSEQ mRNAs for XBP1 gene (2 alternative transcripts):

NM_001079539.1 NM_005080.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001079539 NM_005080

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001079539
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001079539
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001079539

Additional cDNA sequence:

AB076383.1 AB076384.1 AK093842.1 AK292188.1 AK313761.1 BC000938.1 BC012841.1 BC015709.1

CR456611.1 CR590520.1 CR592784.1 CR596883.1 CR599357.1 CR601294.1 CR602065.1 CR602567.1

CR604618.1 CR605083.1 CR605464.1 CR605548.1 CR606064.1 CR608173.1 CR608333.1 CR608589.1

CR609562.1 CR609625.1 CR615221.1 CR615523.1 CR619162.1 CR619584.1 CR621632.1 CR622994.1

CR623851.1 CR624460.1 CR624514.1 CR624707.1 CR625623.1 M31627.1

24/39 DOTS entries (see all 39 ):

DT.97768015 DT.453400 DT.95200416 DT.100890065 DT.95247259 DT.100890079 DT.420045 DT.95247456

DT.100833925 DT.100890066 DT.100890057 DT.100890063 DT.100681205 DT.100890062 DT.100890083 DT.100890080

DT.100890087 DT.429997 DT.97855250 DT.95366361 DT.100890047 DT.100890071 DT.420044 DT.100890090

24/1012 AceView cDNA sequences (see all 1012 ):

BM993787 BG036223 BI439018 AA394240 AA480365 BU508055 BE390408 BU860468

BI496945 CR619162 AW662546 CR605548 H88955 BE315337 BM686207 BM977844

BM663600 BM919810 BM977086 AI355804 BQ420792 CR615523 CA309023 AA932491

highest scoring ESTs for XBP1:

AA054434 AA158368 AA337132 AB076383 AB076384 AV689523 AV691247 AV694904 BC000938 BC012841

Unigene Cluster for XBP1:

X-box binding protein 1

Hs.437638 [show with all ESTs]

Unigene Representative Sequence: AK093842

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for XBP1

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7a	·	7b	·	7c
SP1:					-				-				-
SP2:									-				-
SP3:					-								-
SP4:					-				-
SP5:

About this scheme

ECgene alternative splicing isoforms for XBP1

4 Ensembl transcripts including schematic representations:

ENST00000405219 ENST00000403532 ENST00000344347 ENST00000216037

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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XBP1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for XBP1

¹ / ² / ³

5 probe-sets matching XBP1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39756_g_at²^{, 3}	U95-A	1	1.00	1.00	0.99	1.04	Z93930	0.20	1.00	0.72	1
39755_at²^{, 3}	U95-A	1	1.00	1.00	0.97	1.21	Z93930	0.20	1.00	0.72	1
71584_at²^{, 3}	U95-E	1	0.50	1.00	0.98	0.76	AA503434	0.60	1.00	0.82	1
200670_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005080	0.60	1.00	0.82	1
200670_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks XBP1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CAATTAAAAG

SOURCE GeneReport for Unigene cluster: Hs.437638
Expression variation in blood from EXPOLDB for XBP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for XBP1 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	XBPP1¹	--	X-box binding protein pseudogene 1	99.62(n) 99.23(a)	458735 XM_515053.2 XP_515053.2
cow (Bos taurus)	XBPP1¹	--	X-box binding protein pseudogene 1	90.42(n) 85.44(a)	541236 NM_001034727.1 NP_001029899.1
rat (Rattus norvegicus)	Xbp1¹	--	X-box binding protein 1	87.53(n) 85.04(a)	289754 NM_001004210.1 NP_001004210.1
mouse (Mus musculus)	Xbp1^{1, 5}	11 (3.00 cM)⁵	X-box binding protein 1^{1, 5}	86.48(n)¹ 83.07(a)¹	22433¹ NM_013842.2¹ NP_038870.2¹ AB036745⁵ AF027963⁵ (see all 43)
zebrafish (Danio rerio)	xbp1²	--	X-box binding protein 1	78.69(n)	140614 AY237651.1

About this table Species with no ortholog for XBP1

ENSEMBL Gene Tree for XBP1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/47 NCBI SNPs in XBP1 are shown (see all 47 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 30)

AB	SNP ID	Valid	Chr 22 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2269577^1,2	A,C,F,H	27526757(+)	`GTTACC/GTGCGG`	2	--	ng3¹		4		EU EA WA	418
	rs3788409^1,2	A,C,F,H	27528151(+)	`CAATTG/TTATTT`	2	--	ng3¹		9		MN CSAM EA EU WA	818
	rs2267131^1,2	C,F,H,O	27520471(+)	`ATTAAT/CTCCTA`	2	--	ng5¹		22		EA EU WA NA MN CSAM	3414
	rs2269576^1,2	F,H	27526747(+)	`TCCGCG/CGGGGG`	2	--	ng3¹		3		EA WA	296
--	rs11705434^1,2	A	27527391(+)	`tttttC/Tttctt`	2	--	ng3¹ trp³		0	--	--	--	--
--	rs34731735^1,2	F	27520637(-)	`AATGCT/CTGATG`	2	--	ut3¹		5		MN CSAM EA	400
--	rs1064181^1,2	H	27521258(-)	`CCCTTT/CCCCCA`	2	P/S	mis¹ ut3¹ trp³		5		MN EU EA WA	590
	rs2269578^1,2	F	27526843(+)	`AAACCG/CAGAGC`	2	--	ng3¹		1		EA	920
--	rs14963^1,2	C	27520643(-)	`TATGTA/GAATGC`	2	--	ut3¹ ese³		6		MN CSAM EA	588
	rs34665258^1,2	F	27520452(-)	`AGTGAG/ACCTAA`	2	--	ng5¹		5		MN CSAM EA	404

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HapMap Linkage Disequilibrium images for XBP1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 194355 disorders: 612371

UniProtKB/Swiss-Prot: XBP1_HUMAN, P17861

Genetic variations in XBP1 could be associated with susceptibility to major affective

disorder type 7 (MAFD7) [MIM:612371]. Major affective disorders represent a class of mental

disorders characterized by a disturbance in mood as their predominant feature

10/19 Novoseek disease relationships for XBP1 gene (see all 19 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
bipolar disorder	60.31	17	12949534 (4), 15331160 (2), 15927087 (1), 16154272 (1) (see all 11)
myeloma	47.96	13	16532968 (3), 17257674 (2), 12902539 (2), 18069259 (1) (see all 6)
lymphoma b-cell	40.24	5	19380033 (5)
plasmacytoma	28.78	2	12925741 (1), 17709512 (1)
colon cancer	27.04	3	17352224 (2)
breast cancer	25.30	19	17660348 (4), 18386815 (3), 14634507 (2), 15487507 (2) (see all 7)
leukemia t-cell	25.02	1	7608116 (1)
shock	19.70	4	17563070 (1), 17932454 (1), 17906960 (1)
inflammatory bowel diseases	16.12	2	18775308 (1), 18775305 (1)
cancer	13.60	3	17352224 (2), 15270080 (1)

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3 PharmGKB disease relationships for XBP1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Bipolar Disorder	CO GN	12949534 15284840
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872
Schizophrenia	CO GN	15298659

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Human Gene Mutation Database: XBP1
Genetic Association Database: XBP1
Human Genome Epidemiology Navigator: XBP1 (15 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

New Cause of Tamoxifen Resistance in Breast Cancer Cells Discovered at Lombardi

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/226 PubMed articles for XBP1 gene (see all 226 ):

Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder. (PubMed id 12949534)^{1, 3, 4, 7} Kakiuchi C....Kato T. (2003)
Association of the XBP1-116C/G polymorphism with schizophrenia in the Japanese population. (PubMed id 15298659)^{3, 6, 7} Kakiuchi C....Kato T. (2004)
Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain. (PubMed id 2196176)^{2, 3, 4} Yoshimura T....Yoshida M. (1990)
The X-box binding protein 1 (XBP1) gene is not associated with methamphetamine dependence. (PubMed id 15936534)^{1, 3, 6} Morita Y....Ozaki N. (2005)
Relationship between XBP1 genotype and personality traits assessed by TCI and NEO-FFI. (PubMed id 16154272)^{1, 3, 6} Kusumi I....Koyama T. (2005)
A possible association between the -116C/G single nucleotide polymorphism of the XBP1 gene and lithium prophylaxis in bipolar disorder. (PubMed id 15927087)^{1, 3, 6} Masui T....Koyama T. (2006)
Lack of association between XBP1 genotype and calcium signaling in the platelets of healthy subjects. (PubMed id 15380296)^{1, 3, 6} Kusumi I....Koyama T. (2004)
X-box binding protein 1 (XBP1) C--116G polymorphisms in bipolar disorders and age of onset. (PubMed id 15331160)^{1, 3, 6} Hou S.J....Hong C.J. (2004)
XBP1 gene polymorphism (-116C/G) and personality. (PubMed id 15892135)^{1, 3, 6} Kato C....Sasaki T. (2005)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{3, 4} Collins J.E.... Dunham I. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 7494	HGNC: 12801	AceView: XBP1	Ensembl:ENSG00000100219	euGenes: HUgn7494
ECgene: XBP1	H-InvDB: XBP1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for XBP1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for XBP1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for XBP1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for XBP1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for XBP1		Antibodies for XBP1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for XBP1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (XBP1)
	Antibodies (XBP1)
	Chimera RNAi (XBP1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (XBP1)
	Antibodies (XBP1)

Search OriGene for XBP1

Search Tocris compounds for XBP1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for XBP1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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XBP1 Gene at Home site.
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XBP1 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for XBP1

Summaries
for XBP1

Genomic Location
for XBP1

Proteins
for XBP1

Protein Domains/
Families
for XBP1

Gene Function
for XBP1

Pathways & Interactions
for XBP1

Drugs & Compounds
for XBP1

Transcripts
for XBP1

Expression
for XBP1

Orthologs
for XBP1

Paralogs
for XBP1

SNPs/Variants
for XBP1

Disorders & Mutations
for XBP1

Medical News
for XBP1

Publications
for XBP1

Search for XBP1

Genome Databases showing XBP1

Other Databases showing XBP1

Specialized Databases showing XBP1

Licensable Technologies
for XBP1

Services
for XBP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

XBP1 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor XBP1

Summariesfor XBP1

Genomic Locationfor XBP1

Proteinsfor XBP1

Protein Domains/Familiesfor XBP1

Gene Functionfor XBP1

Pathways & Interactionsfor XBP1

Drugs & Compoundsfor XBP1

Transcriptsfor XBP1

Expression for XBP1

Orthologsfor XBP1

Paralogsfor XBP1

SNPs/Variantsfor XBP1

Disorders & Mutationsfor XBP1

Medical Newsfor XBP1

Publicationsfor XBP1

Search for XBP1

Genome Databases showing XBP1

Other Databases showing XBP1

Specialized Databases showing XBP1

Licensable Technologiesfor XBP1

Servicesfor XBP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for XBP1

Summaries
for XBP1

Genomic Location
for XBP1

Proteins
for XBP1

Protein Domains/
Families
for XBP1

Gene Function
for XBP1

Pathways & Interactions
for XBP1

Drugs & Compounds
for XBP1

Transcripts
for XBP1

Expression
for XBP1

Orthologs
for XBP1

Paralogs
for XBP1

SNPs/Variants
for XBP1

Disorders & Mutations
for XBP1

Medical News
for XBP1

Publications
for XBP1

Licensable Technologies
for XBP1

Services
for XBP1