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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

XAGE5 Gene

protein-coding   GIFtS: 38
GCID: GC0XP052857

X Antigen Family, Member 5

(Previous names: G antigen, family D, 5)
(Previous symbol: GAGED5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
X Antigen Family, Member 51 2     XAGE-52 3
GAGED51 2 3     Cancer/Testis Antigen Family 121
G Antigen, Family D, 51 2     Member 51
Cancer/Testis Antigen 12.52 3     Cancer/Testis Antigen Family 12, Member 52
G Antigen Family D Member 52 3     Protein XAGE-52
CT12.52 3     X Antigen Family Member 52

External Ids:    HGNC: 309301   Entrez Gene: 1706272   Ensembl: ENSG000001714057   UniProtKB: Q8WWM13   

Export aliases for XAGE5 gene to outside databases

Previous GC identifers: GC0XP052726 GC0XP049907


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for XAGE5 Gene:
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a
variety of tumors and in some fetal and reproductive tissues. The protein encoded by this gene shares a sequence
similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this
protein also belongs to a family of CT (cancer-testis) antigens. (provided by RefSeq, Jul 2008)

GeneCards Summary for XAGE5 Gene: 
XAGE5 (X antigen family, member 5) is a protein-coding gene. Diseases associated with XAGE5 include sarcoma, and melanoma. An important paralog of this gene is GAGE2D.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011630.14  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the XAGE5 gene promoter:
         TBP   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidXAGE5 promoter sequence
   Search SABiosciences Chromatin IP Primers for XAGE5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XAGE5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.22   Ensembl cytogenetic band:  Xp11.22   HGNC cytogenetic band: Xp11.23

XAGE5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XAGE5 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP052857:  view genomic region     (about GC identifiers)

Start:
52,841,228 bp from pter      End:
52,847,325 bp from pter
Size:
6,098 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: XAGE5_HUMAN, Q8WWM1 (See protein sequence)
Recommended Name: X antigen family member 5  
Size: 108 amino acids; 12077 Da
Secondary accessions: Q5JS81

Explore the universe of human proteins at neXtProt for XAGE5: NX_Q8WWM1

Explore proteomics data for XAGE5 at MOPED 

XAGE5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

XAGE5 Protein Expression

REFSEQ proteins: NP_570131.1  
ENSEMBL proteins: 
 ENSP00000364651   ENSP00000342240   ENSP00000392864   ENSP00000364653  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR008625 GAGE

Graphical View of Domain Structure for InterPro Entry Q8WWM1

ProtoNet protein and cluster: Q8WWM1

1 Blocks protein domain: IPB008625 GAGE

UniProtKB/Swiss-Prot: XAGE5_HUMAN, Q8WWM1
Similarity: Belongs to the GAGE family


XAGE5 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
     2 GenomeRNAi human phenotypes for XAGE5:
 Decreased Wnt reporter activit  Increased number of cells in m 

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for XAGE5

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for XAGE5

Search CenterWatch for drugs/clinical trials and news about XAGE5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for XAGE5 gene: 
NM_130775.2  

Unigene Cluster for XAGE5:

X antigen family, member 5
Hs.356874  [show with all ESTs]
Unigene Representative Sequence: BC103962
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000375501 ENST00000445860 ENST00000351072 ENST00000425386(uc004drd.1)
ENST00000375503
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Additional mRNA sequence: 

BC069129.1 BC103962.1 BC103963.1 BC103964.1 

2 DOTS entries:

DT.121305250  DT.99947034 

3 AceView cDNA sequences:

NM_130775 AI123309 BC069129 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for XAGE5    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1:                    -                           
SP2:                    -     -                     
SP3:                                                


ECgene alternative splicing isoforms for XAGE5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

XAGE5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
XAGE5 Expression
About this image


See XAGE5 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.356874
    SABiosciences Custom PCR Arrays for XAGE5
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of mammals.

Orthologs for XAGE5 gene from 1/2 species (see all 2)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia --
--
--
46(a)
38(a)
possible ortholog
1 ↔ many
X(42409468-42417781)
X(44845511-44852279)


ENSEMBL Gene Tree for XAGE5 (if available)
TreeFam Gene Tree for XAGE5 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for XAGE5 gene
GAGE2D2  XAGE32  GAGE12H2  GAGE102  GAGE12I2  XAGE2B2  GAGE12C2  GAGE12E2  
GAGE12D2  GAGE2E2  GAGE12  GAGE2C2  GAGE12F2  GAGE132  PAGE12  XAGE22  
GAGE12G2  GAGE2B2  GAGE2A2  GAGE12J2  
18/33 SIMAP similar genes for XAGE5 using alignment to 2 protein entries:     XAGE5_HUMAN (see all proteins) (see all similar genes):
PAGE3    XAGE3    XAGE2    XAGE2B    XAGE-4    PAGE1
PAGE2    PAGE5    PAGE4    GAGE10    GAGE2D    GAGE2E
GAGE3    GAGE8    PAGE2B    GAGE1    GAGE13    GAGE2A

XAGE5 for paralogs           About GeneDecksing


5/7 Pseudogenes.org Pseudogenes for XAGE5 (see all 7)
PGOHUM00000241302 PGOHUM00000241308 PGOHUM00000250051 PGOHUM00000241339 PGOHUM00000241768


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/128 SNPs in XAGE5 are shown (see all 128)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1903806181,2
--52839723(+) ACCACA/GGTCAG 1 -- us2k10--------
rs1815881001,2
--52839749(+) CTCAAC/TGGGCA 1 -- us2k10--------
rs1452033291,2
C--52839924(+) GGAAAA/GCAGAA 1 -- us2k10--------
rs28070371,2
C,F,A,H--52839930(-) AAGCCT/CTTCTG 1 -- us2k116Minor allele frequency- C:0.04NS WA NA CSA 1182
rs562495451,2
C,F--52839936(+) GGCTTT/CCCGTG 1 -- us2k11Minor allele frequency- C:0.00NA 1
rs28070361,2
C,F,A,H--52839943(-) TCCAAC/ACCACG 1 -- us2k110Minor allele frequency- A:0.13NS WA NA CSA 138
rs1809279791,2
--52839949(+) TTGGAC/TCACTC 1 -- us2k10--------
rs1851931491,2
--52840135(+) GGCATA/TAAAAA 1 -- us2k10--------
rs1906838731,2
--52840324(+) CCCTTC/TGCCCA 1 -- us2k10--------
rs1132224581,2
C,F--52840345(+) GTGATC/G/TCTGCA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for XAGE5 (52841228 - 52847325 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for XAGE5:    About this table     
Variant IDTypeSubtypePubMed ID
esv2740170CNV Deletion23290073
nsv7446OTHER Inversion18451855

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for XAGE5:    About MalaCards
sarcoma    melanoma


XAGE5 for disorders           About GeneDecksing


Export disorders for XAGE5 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for XAGE5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with XAGE5)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
  4. The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PubMed id 11992404)1, 2 Zendman A.J.W....van Muijen G.N.P. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 170627 HGNC: 30930 AceView: GAGED5 Ensembl:ENSG00000171405 euGenes: HUgn170627
ECgene: XAGE5 H-InvDB: XAGE5

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for XAGE5 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for XAGE5 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for XAGE5 gene:
Search GeneIP for patents involving XAGE5

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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About This Section

 
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 CLIAs for XAGE5
 Search LifeMap BioReagents cell lines for XAGE5
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XAGE5
 Browse SwitchGear 3'UTR luciferase reporter plasmids for XAGE5
 SwitchGear Promoter luciferase reporter plasmids for XAGE5
 ThermoFisher Antibodies for XAGE5
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XAGE5
 inGenious Targeting Laboratory - Custom generated mouse model solutions for XAGE5
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for XAGE5
Customized:
 lentivirus for stable overexpression of XAGE5
 lentivirus expression plasmids for stable overexpression of XAGE5
 adenovirus for overexpression of XAGE5
 LSBio Antibodies in human, mouse, rat for XAGE5
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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