Aliases for XAGE5 Gene
Aliases for XAGE5 Gene
External Ids for XAGE5 Gene
- HGNC: 30930
- Entrez Gene: 170627
- Ensembl: ENSG00000171405
- UniProtKB: Q8WWM1
Previous HGNC Symbols for XAGE5 Gene
- GAGED5
Previous GeneCards Identifiers for XAGE5 Gene
- GC0XP052726
- GC0XP049907
Summaries for XAGE5 Gene
-
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. [provided by RefSeq, Jul 2008]
GeneCards Summary for XAGE5 Gene
XAGE5 (X Antigen Family Member 5) is a Protein Coding gene. An important paralog of this gene is XAGE3.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XAGE5 Gene
Genomics for XAGE5 Gene
GeneHancer (GH) Regulatory Elements for XAGE5 Gene
Promoters and enhancers for XAGE5 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH0XI052992 | Enhancer | 0.2 | FANTOM5 | 5.6 | +181.3 | 181320 | 0 | XAGE5 GPR173 FAM156A GC0XP052962 | ||
| GH0XI053126 | Enhancer | 0.5 | FANTOM5 | 1.4 | +315.0 | 315022 | 0.4 | ZNF316 NFE2 | FAM156A GPR173 IQSEC2 XAGE5 FAM156B TSPYL2 RNU7-37P ENSG00000235224 KANTR |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around XAGE5 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the XAGE5 gene promoter:
Regulatory Element Products
Genomic Locations for XAGE5 Gene
Genomic Locations for XAGE5 Gene
- chrX:52,811,294-52,818,301
- (GRCh38/hg38)
- Size:
- 7,008 bases
- Orientation:
- Plus strand
- chrX:52,841,228-52,847,325
- (GRCh37/hg19)
Genomic View for XAGE5 Gene
Genes around XAGE5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp11.22 by Ensembl
- Xp11.22 by Entrez Gene
- Xp11.22 by HGNC
XAGE5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for XAGE5 Gene
Proteins for XAGE5 Gene
-
Protein details for XAGE5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8WWM1-XAGE5_HUMAN
- Recommended name:
- X antigen family member 5
- Protein Accession:
- Q8WWM1
- Q5JS81
Protein attributes for XAGE5 Gene
- Size:
- 108 amino acids
- Molecular mass:
- 12077 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for XAGE5 Gene
No Post-translational modifications
Other Protein References for XAGE5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for XAGE5
- Invitrogen Antibodies for XAGE5
- Search GeneTex for Antibodies for XAGE5
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for XAGE5
- Origene Custom Protein Services for XAGE5
- Novus Biologicals proteins for XAGE5
- Search GeneTex for Proteins for XAGE5
Assay Products
No data available for DME Specific Peptides for XAGE5 Gene
Domains & Families for XAGE5 Gene
Gene Families for XAGE5 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for XAGE5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8WWM1- Family:
-
- Belongs to the GAGE family.
Function for XAGE5 Gene
Phenotypes for XAGE5 Gene
- GenomeRNAi human phenotypes for XAGE5:
-
- Decreased hepcidin::fluc mRNA expression
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability ratio
- Increased transferrin (TF) endocytosis
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Downregulation of Wnt pathway after Wnt3A stimulation
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for XAGE5
-
-
ViGene Biosciences lentiviral particle packaged cDNA for XAGE5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for XAGE5 gene
- Search ViGene Biosciences for XAGE5
CRISPR Products
-
OriGene CRISPR knockouts for XAGE5
- genomics-online: gRNA clones - Search results for available XAGE5 gene related products
- Applied Biological Materials CRISPR for XAGE5
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for XAGE5
- GenScript: Design CRISPR guide RNA sequences for XAGE5
miRNA Products
- Search ViGene Biosciences for XAGE5
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for XAGE5
- Browse OriGene Inhibitory RNA Products For XAGE5
- genomics-online: shRNA clones - Search results for available XAGE5 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for XAGE5 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for XAGE5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for XAGE5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available XAGE5 gene related products
- orf clones - Search results for available XAGE5 gene related products
- Applied Biological Materials Clones for XAGE5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for XAGE5
-
ViGene Biosciences adenoviral particle packaged cDNA for XAGE5 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for XAGE5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for XAGE5 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for XAGE5 Gene
Localization for XAGE5 Gene
| Compartment | Confidence |
|---|---|
| mitochondrion | 3 |
| nucleus | 2 |
| cytosol | 1 |
- Nucleoplasm (2)
- Vesicles (2)
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for XAGE5 Gene
Transcripts for XAGE5 Gene
mRNA/cDNA for XAGE5 Gene
- (2) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (3) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for XAGE5 Gene
CRISPR Products
-
OriGene CRISPR knockouts for XAGE5
- genomics-online: gRNA clones - Search results for available XAGE5 gene related products
- Applied Biological Materials CRISPR for XAGE5
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for XAGE5
- GenScript: Design CRISPR guide RNA sequences for XAGE5
miRNA Products
- Search ViGene Biosciences for XAGE5
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for XAGE5
- Browse OriGene Inhibitory RNA Products For XAGE5
- genomics-online: shRNA clones - Search results for available XAGE5 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for XAGE5 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for XAGE5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for XAGE5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available XAGE5 gene related products
- orf clones - Search results for available XAGE5 gene related products
- Applied Biological Materials Clones for XAGE5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||
| SP2: | - | - | |||||||||||||
| SP3: |
Expression for XAGE5 Gene
mRNA differential expression in normal tissues according to GTEx for XAGE5 Gene
This gene is overexpressed in Testis (x47.3) and Brain - Spinal cord (cervical c-1) (x4.4).
NURSA nuclear receptor signaling pathways regulating expression of XAGE5 Gene:
XAGE5SOURCE GeneReport for Unigene cluster for XAGE5 Gene:
Hs.356874Primer Products
-
OriGene qPCR primer pairs for XAGE5
- genomics-online: primer clones - Search results for available XAGE5 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for XAGE5 Gene
Orthologs for XAGE5 Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LOC743413 33 |
|
||
| XAGE5 34 |
|
OneToOne |
- Species where no ortholog for XAGE5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for XAGE5 Gene
(33) SIMAP similar genes for XAGE5 Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for XAGE5 Gene
Variants for XAGE5 Gene
| SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1003005575 | -- | 52,809,551(+) | T/C | upstream_transcript_variant | |
| rs1003358942 | -- | 52,810,080(+) | C/T | upstream_transcript_variant | |
| rs1006755160 | -- | 52,809,428(+) | A/G | upstream_transcript_variant | |
| rs1008271768 | -- | 52,811,037(+) | G/C | upstream_transcript_variant | |
| rs1013066009 | -- | 52,810,665(+) | G/T | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2740170 | CNV | deletion | 23290073 |
| esv3576877 | CNV | gain | 25503493 |
| nsv7446 | OTHER | inversion | 18451855 |
Residual Variation Intolerance Score:
62.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.15;
3.42% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for XAGE5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- XAGE5
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XAGE5 Gene
Disorders for XAGE5 Gene
Additional Disease Information for XAGE5
No disorders were found for XAGE5 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XAGE5 Gene
Publications for XAGE5 Gene
- The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
- The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PMID: 11992404) Zendman AJ … Van Muijen GN (International journal of cancer 2002) 3 4 58
Products for XAGE5 Gene
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- Browse Primary Antibodies
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- Browse ELISAs
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- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for XAGE5
- Origene Custom Protein Services for XAGE5
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- OriGene qPCR primer pairs for XAGE5
- OriGene CRISPR knockouts for XAGE5
- OriGene ORF clones in human for XAGE5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For XAGE5
- GenScript: Next-day shipping of latest version cDNA ORF clones for XAGE5 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for XAGE5
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- GenScript: Design CRISPR guide RNA sequences for XAGE5
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for XAGE5
- Novus Biologicals proteins for XAGE5
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for XAGE5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for XAGE5
- VectorBuilder custom plasmid, inducible vectors for XAGE5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for XAGE5
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available XAGE5 related products ranked by validation data
- antibodies-online: Search results for available XAGE5 related products ranked by validation data
- antibodies-online: Search results for available XAGE5 related products ranked by validation data
- Search GeneTex for Antibodies for XAGE5
- Search GeneTex for Proteins for XAGE5
- ViGene Biosciences adenoviral particle packaged cDNA for XAGE5 gene
- ViGene Biosciences lentiviral particle packaged cDNA for XAGE5 gene
- ViGene Biosciences ready-to-package AAV shRNAs for XAGE5 gene
- Search ViGene Biosciences for XAGE5
- Horizon Cell Lines for XAGE5
- genomics-online: cdna clones - Search results for available XAGE5 gene related products
- orf clones - Search results for available XAGE5 gene related products
- genomics-online: gRNA clones - Search results for available XAGE5 gene related products
- genomics-online: primer clones - Search results for available XAGE5 gene related products
- genomics-online: shRNA clones - Search results for available XAGE5 gene related products
Sources for XAGE5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew