XAGE5 Gene
protein-coding GIFtS: 38
GCID: GC0XP052857
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X antigen family, member 5(Previous names: G antigen, family D, 5 )
(Previous symbol: GAGED5)
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Aliases
for XAGE5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
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| X Antigen Family, Member 51 2 | | Cancer/Testis Antigen 12.52 3 | | CT12.51 2 3 | | Protein XAGE-52 3 | | GAGED51 2 3 | | Cancer/Testis Antigen Family 12, Member 52 | | XAGE-51 2 | | G Antigen Family D Member 52 | | G Antigen, Family D, 51 2 | | |
Export aliases for XAGE5 gene to outside databasesPrevious GC identifers: GC0XP052726 GC0XP049907 |
Summaries
for XAGE5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for XAGE5:
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in avariety of tumors and in some fetal and reproductive tissues. The protein encoded by this gene shares a sequencesimilarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this proteinalso belongs to a family of CT (cancer-testis) antigens. (provided by RefSeq, Jul 2008)
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Genomic Views
for XAGE5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011630.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the XAGE5 gene promoter:
TBP
Other transcription factors
Search SABiosciences Chromatin IP Primers for XAGE5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XAGE5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.22 Ensembl cytogenetic band: Xp11.22 HGNC cytogenetic band: Xp11.23XAGE5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP052857: view genomic region
(about GC identifiers)
Start:
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52,841,228 bp from pter |
End:
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52,847,325 bp from pter |
Size:
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6,098 bases |
Orientation:
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plus strand |
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Proteins
for XAGE5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GAGD5_HUMAN, Q8WWM1 (See
protein sequence)Recommended Name: G antigen family D member 5 Size: 108 amino acids; 12077 Da
Secondary accessions: Q5JS81Explore the universe of human proteins at neXtProt for XAGE5: NX_Q8WWM1
XAGE5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_570131.1
ENSEMBL proteins: ENSP00000364651 ENSP00000342240 ENSP00000392864 ENSP00000364653
Human Recombinant Protein Products:
XAGE5 Antibody Products:
Assay Products for XAGE5: |
Protein
Domains /
Families
for XAGE5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
XAGE5 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8WWM1ProtoNet protein and cluster: Q8WWM1 1 Blocks protein family: IPB008625 GAGE
UniProtKB/Swiss-Prot: GAGD5_HUMAN, Q8WWM1Similarity: Belongs to the GAGE family |
Function
for XAGE5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XAGE5
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XAGE5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: XAGE5 (NM_130775) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XAGE5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XAGE5 |
2 GenomeRNAi human phenotypes for XAGE5:
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Pathways & Interactions
for XAGE5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for XAGE5
|
Drugs & Compounds
for XAGE5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for XAGE5
Search CenterWatch for drugs/clinical trials and news about XAGE5 / GAGD5
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Transcripts
for XAGE5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for XAGE5 gene: NM_130775.2 Unigene Cluster for XAGE5: X antigen family, member 5 Hs.356874 [show with all ESTs]Unigene Representative Sequence: BC1039625 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000375501 ENST00000445860 ENST00000351072 ENST00000425386(uc004drd.1)
ENST00000375503
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XAGE5
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XAGE5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: XAGE5 (NM_130775) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XAGE5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XAGE5 |
Additional cDNA sequence: BC069129.1 BC103962.1 BC103963.1 BC103964.1 2 DOTS entries: DT.121305250 DT.99947034 3 AceView cDNA sequences: NM_130775 BC069129 AI123309
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for XAGE5 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b |
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| SP1: | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for XAGE5
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Expression
for XAGE5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| XAGE5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See XAGE5 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.356874
SABiosciences Custom PCR Arrays for XAGE5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XAGE5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat XAGE5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XAGE5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XAGE5 |
Orthologs
for XAGE5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for XAGE5 (if available)
TreeFam Gene Tree for XAGE5 (if available) |
Paralogs
for XAGE5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for XAGE5 gene
- PAGE22 GAGE2D2 GAGE42 XAGE32 GAGE102 GAGE12H2 GAGE12I2 PAGE32
- XAGE2B2 PAGE52 GAGE12C2 GAGE12E2 GAGE12D2 PAGE2B2 GAGE12 GAGE2E2
- GAGE2C2 GAGE12F2 PAGE12 GAGE132 XAGE22 GAGE12G2 GAGE2A2 GAGE2B2
- PAGE42 GAGE12J2
18/33 SIMAP similar genes for XAGE5 using alignment to 2 protein entries: GAGD5_HUMAN (see all proteins)
(see all similar genes):PAGE3 XAGE3 XAGE2 XAGE2B XAGE-4 PAGE1
PAGE2 PAGE5 PAGE4 GAGE10 GAGE2D GAGE2E
GAGE3 GAGE8 PAGE2B GAGE1 GAGE13 GAGE2A
XAGE5 for paralogs About GeneDecksing
5/7 Pseudogenes.org Pseudogenes for XAGE5 (see all 7)
PGOHUM00000241302 PGOHUM00000241308 PGOHUM00000250051 PGOHUM00000241339 PGOHUM00000241768
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Genomic Variants
for XAGE5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for XAGE5 (52841228 - 52847325 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for XAGE5
1 Inversion: 37382 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for XAGE5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
XAGE5 for disorders About GeneDecksing
2  diseases for XAGE5: About MalaCardssarcoma melanoma
Export disorders for XAGE5 gene to outside databases
|
Publications
for XAGE5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for XAGE5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with XAGE5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PubMed id 11992404)1, 2 Zendman A.J.W....van Muijen G.N.P. (2002)
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External Searches for XAGE5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing XAGE5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing XAGE5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing XAGE5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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About This Section
| Patent Information for XAGE5 gene:
Search GeneIP for patents involving XAGE5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for XAGE5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for XAGE5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for XAGE5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XAGE5 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for XAGE5 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XAGE5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XAGE5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for XAGE5 | | OriGene Custom Protein Services for XAGE5 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat XAGE5 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XAGE5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XAGE5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XAGE5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XAGE5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XAGE5 |
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| | | | Search Tocris compounds for XAGE5 |
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 | | | XAGE5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for XAGE5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XAGE5 |
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