XAGE5 Gene protein-coding GIFtS : 38 GCID: GC0X P052857
X Antigen Family, Member 5 G antigen, family D, 5 )GAGED5 )
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Aliasesfor XAGE5 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb ,
12 H-InvDB ,
13 NCBI ,
14 NONCODE ,
and/or 15 RNAdb )About This Section Aliases X Antigen Family, Member 5 1 2 XAGE-52 3 GAGED51 2 3 Cancer/Testis Antigen Family 121 G Antigen, Family D, 51 2 Member 51 Cancer/Testis Antigen 12.52 3 Cancer/Testis Antigen Family 12, Member 52 G Antigen Family D Member 52 3 Protein XAGE-52 CT12.52 3 X Antigen Family Member 52
Export aliases for XAGE5 gene to outside databases Previous GC identifers: GC0XP052726 GC0XP049907
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Summariesfor XAGE5 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for XAGE5 Gene: This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in avariety of tumors and in some fetal and reproductive tissues. The protein encoded by this gene shares a sequencesimilarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, thisprotein also belongs to a family of CT (cancer-testis) antigens. (provided by RefSeq, Jul 2008) GeneCards Summary for XAGE5 Gene: XAGE5 (X antigen family, member 5) is a protein-coding gene. Diseases associated with XAGE5 include sarcoma melanoma GAGE2D .
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Genomic Viewsfor XAGE5 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 73) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000023.10 NT_011630.14 NC_018934.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the XAGE5 gene promoter:TBP Other transcription factors Search SABiosciences Chromatin IP Primers for XAGE5 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XAGE5
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: Xp11.22 Ensembl cytogenetic band: Xp11.22 HGNC cytogenetic band: Xp11.23 XAGE5 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XP052857: view genomic region
(about GC identifiers )
Start: 52,841,228 bp from pter End:
52,847,325 bp from pter
Size: 6,098 bases Orientation:
plus strand
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Proteinsfor XAGE5 gene
(According to
UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE 1 MOPED ,
2 PaxDb , and 3 MAXQB
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Cloud-Clone Corp. ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Cloud-Clone Corp. ,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
LSBio ,
Abcam , and/or
Cloud-Clone Corp. )
About This Section UniProtKB/Swiss-Prot: XAGE5_HUMAN, Q8WWM1 See
protein sequence )Recommended Name: Size : 108 amino acids; 12077 DaSecondary accessions : Q5JS81Explore the universe of human proteins at neXtProt for XAGE5: NX_Q8WWM1 Explore proteomics data for XAGE5 at MOPED XAGE5 Protein expression data from MOPED1 2 3 : About this image
REFSEQ proteins: NP_570131.1 ENSEMBL proteins: ENSP00000364651 ENSP00000342240 ENSP00000392864 ENSP00000364653 Human Recombinant Protein Products for XAGE5: XAGE5 Antibody Products: Assay Products for XAGE5:
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Protein
Domains /for XAGE5 gene (According to HGNC , IUPHAR , InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section 1 InterPro protein domain :
Graphical View of Domain Structure for InterPro Entry Q8WWM1 ProtoNet protein and cluster: Q8WWM1
1 Blocks protein domain : IPB008625 UniProtKB/Swiss-Prot: XAGE5_HUMAN, Q8WWM1 Similarity : Belongs to the GAGE familyAbout GeneDecksing
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Functionfor XAGE5 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
genOway ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
Vector BioLabs ,
and Sirion Biotech ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene .)
About This Section Phenotypes: 2 GenomeRNAi human phenotypes for XAGE5 :Animal Models: Cell Line GenScript Custom overexpressing Cell Line Services for XAGE5 Search LifeMap BioReagents cell lines for XAGE5 In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XAGE5
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Pathways & Interactionsfor XAGE5 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Sino Biological ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for XAGE5
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Drugs & Compoundsfor XAGE5 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek ,
Ligands according to IUPHAR ,
and Drugs according to DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for XAGE5 XAGE5
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Transcriptsfor XAGE5 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , KenesGroup ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Sirion Biotech ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for XAGE5 gene: NM_130775.2 Unigene Cluster for XAGE5:
X antigen family, member 5 Hs.356874 [show with all ESTs ] Unigene Representative Sequence: BC103962 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000375501 ENST00000445860 ENST00000351072 ENST00000425386 (uc004drd.1 )ENST00000375503 Primer human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat
Additional mRNA sequence: BC069129.1 BC103962.1 BC103963.1 BC103964.1
2 DOTS entries : DT.121305250 DT.99947034
3 AceView cDNA sequences :
NM_130775 AI123309 BC069129 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for XAGE5 About this scheme ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b SP1 : - SP2 : - - SP3 :
ECgene alternative splicing isoforms for XAGE5
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Expression for XAGE5 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section XAGE5 expression in normal human tissues
(normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS 2/3 CGAP TAG: -- About this image
See XAGE5 Protein Expression from SPIRE MOPED and PaxDB SOURCE GeneReport for Unigene cluster: Hs.356874 SABiosciences Custom PCR Arrays for XAGE5 Primer human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XAGE5
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Orthologsfor XAGE5 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for XAGE5 gene from 1/2 species (see all 2 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
dog Mammalia ----
--
46(a) 38(a)
possible ortholog1 ↔ many
X(42409468-42417781) X(44845511-44852279)
ENSEMBL Gene Tree for XAGE5 (if available)TreeFam Gene Tree for XAGE5 (if available)
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Paralogsfor XAGE5 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for XAGE5 gene GAGE2D 2 XAGE3 2 GAGE12H 2 GAGE10 2 GAGE12I 2 XAGE2B 2 GAGE12C 2 GAGE12E 2 GAGE12D 2 GAGE2E 2 GAGE1 2 GAGE2C 2 GAGE12F 2 GAGE13 2 PAGE1 2 XAGE2 2 GAGE12G 2 GAGE2B 2 GAGE2A 2 GAGE12J 2 18/33 SIMAP similar genes for XAGE5 using alignment to 2 protein entries: XAGE5_HUMAN (see all proteins )
(see all similar genes ):PAGE3 XAGE3 XAGE2 XAGE2B XAGE-4 PAGE1 PAGE2 PAGE5 PAGE4 GAGE10 GAGE2D GAGE2E GAGE3 GAGE8 PAGE2B GAGE1 GAGE13 GAGE2A About GeneDecksing 5/7 Pseudogenes.org Pseudogenes for XAGE5 (see all 7 )PGOHUM00000241302 PGOHUM00000241308 PGOHUM00000250051 PGOHUM00000241339 PGOHUM00000241768
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Genomic Variantsfor XAGE5 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
4 UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr X pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for XAGE5 (52841228 - 52847325 bp)
Structural Variations Database of Genomic Variants (DGV) 2 variations for XAGE5 : About this table SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor XAGE5 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Conferences by KenesGroup ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section 2 : About MalaCards sarcoma melanoma About GeneDecksing Export disorders for XAGE5 gene to outside databases
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Publicationsfor XAGE5 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for XAGE5 gene integrated from 9 sources :(articles sorted by number of sources associating them with XAGE5) Utopia : connect your pdf to the dynamic
The DNA sequence of the human X chromosome. (PubMed id 15772651) 1 , 2 (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3(2002) The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PubMed id 11992404) 1 , 2 (2002)
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External Searches for XAGE5 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing XAGE5 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing XAGE5 gene
(According to HUGE )
About This Section --
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Specialized Databases showing XAGE5 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for XAGE5 gene: XAGE5 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor XAGE5 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Cloud-Clone Corp. , Thermo Fisher Scientific , LSBio , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Sirion Biotech , Cell lines from GenScript , and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory ,
genOway )About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat XAGE5 Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XAGE5 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XAGE5 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Search Tocris compounds for XAGE5
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XAGE5
ThermoFisher Antibodies for XAGE5
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse rat XAGE5
LSBio Antibodies in human mouse rat
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