Aliases for XAGE5 Gene
Aliases for XAGE5 Gene
External Ids for XAGE5 Gene
- HGNC: 30930
- Entrez Gene: 170627
- Ensembl: ENSG00000171405
- UniProtKB: Q8WWM1
Previous HGNC Symbols for XAGE5 Gene
- GAGED5
Previous GeneCards Identifiers for XAGE5 Gene
- GC0XP052726
- GC0XP049907
Summaries for XAGE5 Gene
-
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. [provided by RefSeq, Jul 2008]
GeneCards Summary for XAGE5 Gene
XAGE5 (X Antigen Family Member 5) is a Protein Coding gene. An important paralog of this gene is GAGE13.
No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XAGE5 Gene
Genomics for XAGE5 Gene
Regulatory Elements for XAGE5 Gene
Enhancers for XAGE5 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around XAGE5 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the XAGE5 gene promoter:
Regulatory Element Products
Genomic Location for XAGE5 Gene
- Chromosome:
- X
- Start:
- 52,811,294 bp from pter
- End:
- 52,818,301 bp from pter
- Size:
- 7,008 bases
- Orientation:
- Plus strand
Genomic View for XAGE5 Gene
Genes around XAGE5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp11.22 by Ensembl
- Xp11.22 by Entrez Gene
- Xp11.23 by HGNC
XAGE5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for XAGE5 Gene
Proteins for XAGE5 Gene
-
Protein details for XAGE5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8WWM1-XAGE5_HUMAN
- Recommended name:
- X antigen family member 5
- Protein Accession:
- Q8WWM1
- Q5JS81
Protein attributes for XAGE5 Gene
- Size:
- 108 amino acids
- Molecular mass:
- 12077 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for XAGE5 Gene
No Post-translational modifications
Other Protein References for XAGE5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Search GeneTex for Antibodies for XAGE5
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for XAGE5
- Origene Custom Protein Services for XAGE5
- Search GeneTex for Proteins for XAGE5
Assay Products
No data available for DME Specific Peptides for XAGE5 Gene
Domains & Families for XAGE5 Gene
Suggested Antigen Peptide Sequences for XAGE5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8WWM1- Family:
-
- Belongs to the GAGE family.
No data available for Gene Families for XAGE5 Gene
Function for XAGE5 Gene
Phenotypes for XAGE5 Gene
- GenomeRNAi human phenotypes for XAGE5:
-
- Decreased hepcidin::fluc mRNA expression
- Mildly decreased CFP-tsO45G cell surface transport
- Increased transferrin (TF) endocytosis
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Downregulation of Wnt pathway after Wnt3A stimulation
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for XAGE5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for XAGE5 gene
- Search ViGene Biosciences for XAGE5
CRISPR Products
-
OriGene CRISPR knockouts for XAGE5
-
Santa Cruz Biotechnology (SCBT) CRISPR for XAGE5
- GenScript: Design CRISPR guide RNA sequences for XAGE5
miRNA Products
- Search ViGene Biosciences for XAGE5
Inhibitory RNA Products
- Origene siRNA, shRNA, and RNAi products in human, mouse, rat for XAGE5
- Browse OriGene Inhibitory RNA Products For XAGE5
-
ViGene Biosciences ready-to-package AAV shRNAs for XAGE5 gene
Clone Products
- OriGene clones in human for XAGE5
- OriGene ORF clones in human for XAGE5
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for XAGE5 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for XAGE5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for XAGE5 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for XAGE5 Gene
Localization for XAGE5 Gene
| Compartment | Confidence |
|---|---|
| mitochondrion | 3 |
| nucleus | 2 |
| cytosol | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for XAGE5 Gene
More details on SuperPathways for XAGE5Transcripts for XAGE5 Gene
mRNA/cDNA for XAGE5 Gene
- (2) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (3) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for XAGE5 Gene
CRISPR Products
-
OriGene CRISPR knockouts for XAGE5
-
Santa Cruz Biotechnology (SCBT) CRISPR for XAGE5
- GenScript: Design CRISPR guide RNA sequences for XAGE5
miRNA Products
- Search ViGene Biosciences for XAGE5
Inhibitory RNA Products
- Origene siRNA, shRNA, and RNAi products in human, mouse, rat for XAGE5
- Browse OriGene Inhibitory RNA Products For XAGE5
-
ViGene Biosciences ready-to-package AAV shRNAs for XAGE5 gene
Clone Products
- OriGene clones in human for XAGE5
- OriGene ORF clones in human for XAGE5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||
| SP2: | - | - | |||||||||||||
| SP3: |
Expression for XAGE5 Gene
mRNA differential expression in normal tissues according to GTEx for XAGE5 Gene
This gene is overexpressed in Testis (x47.3) and Brain - Spinal cord (cervical c-1) (x4.4).
SOURCE GeneReport for Unigene cluster for XAGE5 Gene Hs.356874
Primer Products
-
OriGene qPCR primer pairs for XAGE5
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for XAGE5 Gene
Orthologs for XAGE5 Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LOC743413 35 |
|
||
| XAGE5 36 |
|
OneToOne |
- Species with no ortholog for XAGE5:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for XAGE5 Gene
Paralogs for XAGE5 Gene
(33) SIMAP similar genes for XAGE5 Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for XAGE5 Gene
Variants for XAGE5 Gene
| SNP ID | Clin | Chr 0X pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs2807036 | -- | 52,810,919(-) | TCCAA(A/C)CCACG | upstream-variant-2KB | |
| rs2807037 | -- | 52,810,906(-) | AAGCC(C/T)TTCTG | upstream-variant-2KB | |
| rs4543711 | -- | 52,817,484(+) | CGGGA(A/G)TAGTT | intron-variant | |
| rs7057686 | -- | 52,814,625(+) | TATTT(C/T)GTACT | intron-variant | |
| rs12840637 | -- | 52,818,055(+) | TATTA(C/G)CCGTA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2740170 | CNV | Deletion | 23290073 |
| nsv7446 | OTHER | Inversion | 18451855 |
Residual Variation Intolerance Score:
62.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.15;
3.42% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for XAGE5 Gene
Disorders for XAGE5 Gene
Relevant External Links for XAGE5
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- XAGE5
No disorders were found for XAGE5 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XAGE5 Gene
Publications for XAGE5 Gene
- The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 67
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
- The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PMID: 11992404) Zendman A.J.W. … van Muijen G.N.P. (Int. J. Cancer 2002) 3
Products for XAGE5 Gene
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- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for XAGE5
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- Origene siRNA, shRNA, and RNAi products in human, mouse, rat for XAGE5
- Browse OriGene Inhibitory RNA Products For XAGE5
- OriGene qPCR primer pairs for XAGE5
- OriGene CRISPR knockouts for XAGE5
- OriGene clones in human for XAGE5
- OriGene ORF clones in human for XAGE5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Design CRISPR guide RNA sequences for XAGE5
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ViGene Biosciences adenoviral particle packaged cDNA for XAGE5 gene
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- ViGene Biosciences ready-to-package AAV shRNAs for XAGE5 gene
- ViGene Biosciences ready-to-package AAV shRNAs for XAGE5 gene
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Sources for XAGE5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
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- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
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- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon