Aliases for XAGE5 Gene
Aliases for XAGE5 Gene
External Ids for XAGE5 Gene
- HGNC: 30930
- Entrez Gene: 170627
- Ensembl: ENSG00000171405
- UniProtKB: Q8WWM1
Previous HGNC Symbols for XAGE5 Gene
- GAGED5
Previous GeneCards Identifiers for XAGE5 Gene
- GC0XP052726
- GC0XP049907
Summaries for XAGE5 Gene
-
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. [provided by RefSeq, Jul 2008]
GeneCards Summary for XAGE5 Gene
XAGE5 (X Antigen Family Member 5) is a Protein Coding gene. An important paralog of this gene is XAGE3.
No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XAGE5 Gene
Genomics for XAGE5 Gene
Regulatory Elements for XAGE5 Gene
Enhancers for XAGE5 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around XAGE5 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the XAGE5 gene promoter:
Regulatory Element Products
Genomic Location for XAGE5 Gene
- Chromosome:
- X
- Start:
- 52,811,294 bp from pter
- End:
- 52,818,301 bp from pter
- Size:
- 7,008 bases
- Orientation:
- Plus strand
Genomic View for XAGE5 Gene
Genes around XAGE5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp11.22 by Ensembl
- Xp11.22 by Entrez Gene
- Xp11.22 by HGNC
XAGE5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for XAGE5 Gene
Proteins for XAGE5 Gene
-
Protein details for XAGE5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8WWM1-XAGE5_HUMAN
- Recommended name:
- X antigen family member 5
- Protein Accession:
- Q8WWM1
- Q5JS81
Protein attributes for XAGE5 Gene
- Size:
- 108 amino acids
- Molecular mass:
- 12077 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for XAGE5 Gene
No Post-translational modifications
Other Protein References for XAGE5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Search GeneTex for Antibodies for XAGE5
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for XAGE5
- Origene Custom Protein Services for XAGE5
- Search GeneTex for Proteins for XAGE5
Assay Products
No data available for DME Specific Peptides for XAGE5 Gene
Domains & Families for XAGE5 Gene
Suggested Antigen Peptide Sequences for XAGE5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8WWM1- Family:
-
- Belongs to the GAGE family.
No data available for Gene Families for XAGE5 Gene
Function for XAGE5 Gene
Phenotypes for XAGE5 Gene
- GenomeRNAi human phenotypes for XAGE5:
-
- Decreased hepcidin::fluc mRNA expression
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability ratio
- Increased transferrin (TF) endocytosis
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Downregulation of Wnt pathway after Wnt3A stimulation
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for XAGE5
-
-
ViGene Biosciences lentiviral particle packaged cDNA for XAGE5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for XAGE5 gene
- Search ViGene Biosciences for XAGE5
CRISPR Products
-
OriGene CRISPR knockouts for XAGE5
- GenScript: Design CRISPR guide RNA sequences for XAGE5
miRNA Products
- Search ViGene Biosciences for XAGE5
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for XAGE5
- Browse OriGene Inhibitory RNA Products For XAGE5
-
ViGene Biosciences ready-to-package AAV shRNAs for XAGE5 gene
Clone Products
-
OriGene ORF clones in human for XAGE5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for XAGE5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for XAGE5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for XAGE5
-
ViGene Biosciences adenoviral particle packaged cDNA for XAGE5 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for XAGE5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for XAGE5 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for XAGE5 Gene
Localization for XAGE5 Gene
| Compartment | Confidence |
|---|---|
| mitochondrion | 3 |
| nucleus | 2 |
| cytosol | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for XAGE5 Gene
Transcripts for XAGE5 Gene
mRNA/cDNA for XAGE5 Gene
- (2) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (3) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for XAGE5 Gene
CRISPR Products
-
OriGene CRISPR knockouts for XAGE5
- GenScript: Design CRISPR guide RNA sequences for XAGE5
miRNA Products
- Search ViGene Biosciences for XAGE5
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for XAGE5
- Browse OriGene Inhibitory RNA Products For XAGE5
-
ViGene Biosciences ready-to-package AAV shRNAs for XAGE5 gene
Clone Products
-
OriGene ORF clones in human for XAGE5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for XAGE5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for XAGE5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||
| SP2: | - | - | |||||||||||||
| SP3: |
Expression for XAGE5 Gene
mRNA differential expression in normal tissues according to GTEx for XAGE5 Gene
This gene is overexpressed in Testis (x47.3) and Brain - Spinal cord (cervical c-1) (x4.4).
NURSA nuclear receptor signaling pathways regulating expression of XAGE5 Gene:
XAGE5SOURCE GeneReport for Unigene cluster for XAGE5 Gene:
Hs.356874Primer Products
-
OriGene qPCR primer pairs for XAGE5
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for XAGE5 Gene
Orthologs for XAGE5 Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LOC743413 34 |
|
||
| XAGE5 35 |
|
OneToOne |
- Species where no ortholog for XAGE5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for XAGE5 Gene
Paralogs for XAGE5 Gene
(33) SIMAP similar genes for XAGE5 Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for XAGE5 Gene
Variants for XAGE5 Gene
| SNP ID | Clin | Chr 0X pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs112445966 | -- | 52,816,133(+) | GAGAC(A/G)GGGTT | intron-variant | |
| rs113222458 | -- | 52,811,321(+) | GTGAT(C/G/T)CTGCA | upstream-variant-2KB, utr-variant-5-prime | |
| rs113286477 | -- | 52,813,684(+) | TGCAA(A/T)GGGAT | intron-variant | |
| rs12840637 | -- | 52,818,055(+) | TATTA(C/G)CCGTA | intron-variant | |
| rs138253902 | -- | 52,812,577(+) | TTGGC(A/G)AGGAA | reference, missense |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2740170 | CNV | deletion | 23290073 |
| esv3576877 | CNV | gain | 25503493 |
| nsv7446 | OTHER | inversion | 18451855 |
Residual Variation Intolerance Score:
62.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.15;
3.42% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for XAGE5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- XAGE5
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XAGE5 Gene
Disorders for XAGE5 Gene
Relevant External Links for XAGE5
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- XAGE5
No disorders were found for XAGE5 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XAGE5 Gene
Publications for XAGE5 Gene
- The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
- The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PMID: 11992404) Zendman A.J.W. … van Muijen G.N.P. (Int. J. Cancer 2002) 3 4 64
Products for XAGE5 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
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- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for XAGE5
- Origene Custom Protein Services for XAGE5
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for XAGE5
- Browse OriGene Inhibitory RNA Products For XAGE5
- OriGene qPCR primer pairs for XAGE5
- OriGene CRISPR knockouts for XAGE5
- OriGene ORF clones in human for XAGE5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For XAGE5
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for XAGE5
- GenScript Custom Assay Services for XAGE5
- GenScript Custom overexpressing Cell Line Services for XAGE5
- GenScript: Design CRISPR guide RNA sequences for XAGE5
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for XAGE5
- Browse Sino Biological cDNA Clones
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- Sino Biological Antibodies
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- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
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- Sino Biological Transfection Reagents
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ViGene Biosciences adenoviral particle packaged cDNA for XAGE5 gene
- ViGene Biosciences lentiviral particle packaged cDNA for XAGE5 gene
- ViGene Biosciences ready-to-package AAV shRNAs for XAGE5 gene
- Search ViGene Biosciences for XAGE5
- Horizon Cell Lines for XAGE5
- Cyagen custom Knockout/knockin (KOKI) mouse models for XAGE5
- VectorBuilder custom plasmid, inducible vectors for XAGE5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for XAGE5
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for XAGE5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
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- (128) Genetics Home Reference
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- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab