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XAGE5 Gene

protein-coding   GIFtS: 39
GCID: GC0XP052857

X Antigen Family, Member 5

(Previous names: G antigen, family D, 5)
(Previous symbol: GAGED5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
X Antigen Family, Member 51 2     XAGE-52 3
GAGED51 2 3     Cancer/Testis Antigen Family 121
G Antigen, Family D, 51 2     Member 51
Cancer/Testis Antigen 12.52 3     Cancer/Testis Antigen Family 12, Member 52
G Antigen Family D Member 52 3     Protein XAGE-52
CT12.52 3     X Antigen Family Member 52

External Ids:    HGNC: 309301   Entrez Gene: 1706272   Ensembl: ENSG000001714057   UniProtKB: Q8WWM13   
ORGUL members:         

Export aliases for XAGE5 gene to outside databases

Previous GC identifers: GC0XP052726 GC0XP049907


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for XAGE5 Gene:
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a
variety of tumors and in some fetal and reproductive tissues. The protein encoded by this gene shares a sequence
similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this
protein also belongs to a family of CT (cancer-testis) antigens. (provided by RefSeq, Jul 2008)

GeneCards Summary for XAGE5 Gene:
XAGE5 (X antigen family, member 5) is a protein-coding gene. Diseases associated with XAGE5 include melanoma, and sarcoma. An important paralog of this gene is GAGE2D.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_011630.15  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the XAGE5 gene promoter:
         TBP   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidXAGE5 promoter sequence
   Search Chromatin IP Primers for XAGE5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat XAGE5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.22   Ensembl cytogenetic band:  Xp11.22   HGNC cytogenetic band: Xp11.23

XAGE5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XAGE5 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP052857:  view genomic region     (about GC identifiers)

Start:
52,841,228 bp from pter      End:
52,847,325 bp from pter
Size:
6,098 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: XAGE5_HUMAN, Q8WWM1 (See protein sequence)
Recommended Name: X antigen family member 5  
Size: 108 amino acids; 12077 Da
Secondary accessions: Q5JS81

Explore the universe of human proteins at neXtProt for XAGE5: NX_Q8WWM1

Explore proteomics data for XAGE5 at MOPED


See XAGE5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_570131.1  
ENSEMBL proteins: 
 ENSP00000364651   ENSP00000342240   ENSP00000392864   ENSP00000364653  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR008625 GAGE

Graphical View of Domain Structure for InterPro Entry Q8WWM1

ProtoNet protein and cluster: Q8WWM1

1 Blocks protein domain: IPB008625 GAGE

UniProtKB/Swiss-Prot: XAGE5_HUMAN, Q8WWM1
Similarity: Belongs to the GAGE family


XAGE5 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     2 GenomeRNAi human phenotypes for XAGE5:
 Decreased Wnt reporter activit  Increased number of cells in m 

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion3
nucleus2
cytosol1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for XAGE5
Interactions:

    Search GeneGlobe Interaction Network for XAGE5

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for XAGE5



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for XAGE5 gene: 
NM_130775.2  

Unigene Cluster for XAGE5:

X antigen family, member 5
Hs.356874  [show with all ESTs]
Unigene Representative Sequence: BC103962
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000375501 ENST00000445860 ENST00000351072 ENST00000425386(uc004drd.1)
ENST00000375503
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Additional mRNA sequence: 

BC069129.1 BC103962.1 BC103963.1 BC103964.1 

2 DOTS entries:

DT.121305250  DT.99947034 

3 AceView cDNA sequences:

NM_130775 BC069129 AI123309 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for XAGE5    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1:                    -                           
SP2:                    -     -                     
SP3:                                                


ECgene alternative splicing isoforms for XAGE5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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XAGE5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
XAGE5 Expression
About this image

XAGE5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

XAGE5 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.356874
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XAGE5

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and chimp.

Orthologs for XAGE5 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia LOC7434131 G antigen family D member 5-like 99.07(n)
98.15(a)
  743413  XM_001147258.2  XP_001147258.2 


ENSEMBL Gene Tree for XAGE5 (if available)
TreeFam Gene Tree for XAGE5 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for XAGE5 gene
GAGE2D2  XAGE32  GAGE12H2  GAGE102  GAGE12I2  XAGE2B2  GAGE12C2  GAGE12E2  
GAGE12D2  GAGE2E2  GAGE12  GAGE2C2  GAGE12F2  GAGE132  PAGE12  XAGE22  
GAGE12G2  GAGE2B2  GAGE2A2  GAGE12J2  
Selected SIMAP similar genes for XAGE5 using alignment to 2 protein entries:     XAGE5_HUMAN (see all proteins) (see all similar genes):
PAGE3    XAGE3    XAGE2    XAGE2B    XAGE-4    PAGE1
PAGE2    PAGE5    PAGE4    GAGE10    GAGE2D    GAGE2E
GAGE3    GAGE8    PAGE2B    GAGE1    GAGE13    GAGE2A

XAGE5 for paralogs           About GeneDecksing


Selected Pseudogenes.org Pseudogenes for XAGE5 (see all 7)
PGOHUM00000241302 PGOHUM00000241308 PGOHUM00000250051 PGOHUM00000241339 PGOHUM00000241768


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for XAGE5 (see all 128)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1903806181,2
--52839723(+) ACCACA/GGTCAG 1 -- us2k10--------
rs1815881001,2
--52839749(+) CTCAAC/TGGGCA 1 -- us2k10--------
rs1452033291,2
C--52839924(+) GGAAAA/GCAGAA 1 -- us2k10--------
rs28070371,2
C,F,A,H--52839930(-) AAGCCT/CTTCTG 1 -- us2k116Minor allele frequency- C:0.04NS WA NA CSA 1182
rs562495451,2
C,F--52839936(+) GGCTTT/CCCGTG 1 -- us2k11Minor allele frequency- C:0.00NA 1
rs28070361,2
C,F,A,H--52839943(-) TCCAAC/ACCACG 1 -- us2k110Minor allele frequency- A:0.13NS WA NA CSA 138
rs1809279791,2
--52839949(+) TTGGAC/TCACTC 1 -- us2k10--------
rs1851931491,2
--52840135(+) GGCATA/TAAAAA 1 -- us2k10--------
rs1906838731,2
--52840324(+) CCCTTC/TGCCCA 1 -- us2k10--------
rs1132224581,2
C,F--52840345(+) GTGATC/G/TCTGCA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for XAGE5 (52841228 - 52847325 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for XAGE5:    About this table    
Variant IDTypeSubtypePubMed ID
esv2740170CNV Deletion23290073
nsv7446OTHER Inversion18451855

Site Specific Mutation Identification with PCR Assays
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DNA2.0 Custom Variant and Variant Library Synthesis for XAGE5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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2 diseases for XAGE5:    
About MalaCards
melanoma    sarcoma


XAGE5 for disorders           About GeneDecksing


Export disorders for XAGE5 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for XAGE5 gene integrated from 10 sources:
(articles sorted by number of sources associating them with XAGE5)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  4. The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PubMed id 11992404)1, 2 Zendman A.J.W....van Muijen G.N.P. (Int. J. Cancer 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 170627 HGNC: 30930 AceView: GAGED5 Ensembl:ENSG00000171405 euGenes: HUgn170627
ECgene: XAGE5 H-InvDB: XAGE5

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for XAGE5 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for XAGE5 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for XAGE5 gene:
Search GeneIP for patents involving XAGE5

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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