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XAGE5 Gene

protein-coding GIFtS: 39
GCID: GC0XP052857

X Antigen Family, Member 5

(Previous names: G antigen, family D, 5)
(Previous symbol: GAGED5)

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
X Antigen Family, Member 5¹ ²		XAGE-5² ³
GAGED5¹ ² ³		Cancer/Testis Antigen Family 12¹
G Antigen, Family D, 5¹ ²		Member 5¹
Cancer/Testis Antigen 12.5² ³		Cancer/Testis Antigen Family 12, Member 5²
G Antigen Family D Member 5² ³		Protein XAGE-5²
CT12.5² ³		X Antigen Family Member 5²

External Ids:	HGNC: 30930¹	Entrez Gene: 170627²	Ensembl: ENSG00000171405⁷	UniProtKB: Q8WWM1³

ORGUL members:

Export aliases for XAGE5 gene to outside databases

Previous GC identifers: GC0XP052726 GC0XP049907

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for XAGE5 Gene:

This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a

variety of tumors and in some fetal and reproductive tissues. The protein encoded by this gene shares a sequence

similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this

protein also belongs to a family of CT (cancer-testis) antigens. (provided by RefSeq, Jul 2008)

GeneCards Summary for XAGE5 Gene:

XAGE5 (X antigen family, member 5) is a protein-coding gene. Diseases associated with XAGE5 include melanoma, and sarcoma. An important paralog of this gene is GAGE2D.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000023.11 NT_011630.15 NC_018934.2

Regulatory elements:

Regulatory transcription factor binding sites in the XAGE5 gene promoter:
TBP
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: XAGE5 promoter sequence

Search Chromatin IP Primers for XAGE5

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat XAGE5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.22 Ensembl cytogenetic band: Xp11.22 HGNC cytogenetic band: Xp11.23

XAGE5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XAGE5 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP052857: view genomic region (about GC identifiers)

Start:	52,841,228 bp from pter	End:	52,847,325 bp from pter
Size:	6,098 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: XAGE5_HUMAN, Q8WWM1 (See protein sequence)

Recommended Name: X antigen family member 5

Size: 108 amino acids; 12077 Da

Secondary accessions: Q5JS81

Explore the universe of human proteins at neXtProt for XAGE5: NX_Q8WWM1

Explore proteomics data for XAGE5 at MOPED

See XAGE5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_570131.1

ENSEMBL proteins:

ENSP00000364651 ENSP00000342240 ENSP00000392864 ENSP00000364653

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:

IPR008625 GAGE

Graphical View of Domain Structure for InterPro Entry Q8WWM1

ProtoNet protein and cluster: Q8WWM1

1 Blocks protein domain: IPB008625 GAGE

UniProtKB/Swiss-Prot: XAGE5_HUMAN, Q8WWM1

Similarity: Belongs to the GAGE family

XAGE5 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
2 GenomeRNAi human phenotypes for XAGE5:

Decreased Wnt reporter activit

Increased number of cells in m

Animal Models:

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS:

Compartment	Confidence
mitochondrion	3
nucleus	2
cytosol	1

About this image

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for XAGE5
Interactions:

Search GeneGlobe Interaction Network for XAGE5

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for XAGE5 gene:

NM_130775.2

Unigene Cluster for XAGE5:

X antigen family, member 5

Hs.356874 [show with all ESTs]

Unigene Representative Sequence: BC103962

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000375501 ENST00000445860 ENST00000351072 ENST00000425386(uc004drd.1)

ENST00000375503

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Additional mRNA sequence:

BC069129.1 BC103962.1 BC103963.1 BC103964.1

2 DOTS entries:

DT.121305250 DT.99947034

3 AceView cDNA sequences:

NM_130775 BC069129 AI123309

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for XAGE5 About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5a	·	5b
SP1:							-
SP2:							-		-
SP3:

ECgene alternative splicing isoforms for XAGE5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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XAGE5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

XAGE5 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

XAGE5 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.356874

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and chimp.

Orthologs for XAGE5 gene from 1 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chimpanzee (Pan troglodytes)	Mammalia	LOC743413¹	G antigen family D member 5-like	99.07(n) 98.15(a)		743413 XM_001147258.2 XP_001147258.2

ENSEMBL Gene Tree for XAGE5 (if available)
TreeFam Gene Tree for XAGE5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for XAGE5 gene

GAGE2D² XAGE3² GAGE12H² GAGE10² GAGE12I² XAGE2B² GAGE12C² GAGE12E²

GAGE12D² GAGE2E² GAGE1² GAGE2C² GAGE12F² GAGE13² PAGE1² XAGE2²

GAGE12G² GAGE2B² GAGE2A² GAGE12J²

Selected SIMAP similar genes for XAGE5 using alignment to 2 protein entries: XAGE5_HUMAN (see all proteins) (see all similar genes):

PAGE3 XAGE3 XAGE2 XAGE2B XAGE-4 PAGE1

PAGE2 PAGE5 PAGE4 GAGE10 GAGE2D GAGE2E

GAGE3 GAGE8 PAGE2B GAGE1 GAGE13 GAGE2A

XAGE5 for paralogs About GeneDecksing

Selected Pseudogenes.org Pseudogenes for XAGE5 (see all 7)
PGOHUM00000241302 PGOHUM00000241308 PGOHUM00000250051 PGOHUM00000241339 PGOHUM00000241768

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190380618^1,2		--	52839723(+)	`ACCACA/GGTCAG`	1	--	us2k¹		0	--	--	--	--
rs181588100^1,2		--	52839749(+)	`CTCAAC/TGGGCA`	1	--	us2k¹		0	--	--	--	--
rs145203329^1,2	C	--	52839924(+)	`GGAAAA/GCAGAA`	1	--	us2k¹		0	--	--	--	--
rs2807037^1,2	C,F,A,H	--	52839930(-)	`AAGCCT/CTTCTG`	1	--	us2k¹		16		NS WA NA CSA	1182
rs56249545^1,2	C,F	--	52839936(+)	`GGCTTT/CCCGTG`	1	--	us2k¹		1		NA	1
rs2807036^1,2	C,F,A,H	--	52839943(-)	`TCCAAC/ACCACG`	1	--	us2k¹		10		NS WA NA CSA	138
rs180927979^1,2		--	52839949(+)	`TTGGAC/TCACTC`	1	--	us2k¹		0	--	--	--	--
rs185193149^1,2		--	52840135(+)	`GGCATA/TAAAAA`	1	--	us2k¹		0	--	--	--	--
rs190683873^1,2		--	52840324(+)	`CCCTTC/TGCCCA`	1	--	us2k¹		0	--	--	--	--
rs113222458^1,2	C,F	--	52840345(+)	`GTGATC/G/TCTGCA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for XAGE5 (52841228 - 52847325 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for XAGE5: About this table

Variant ID	Type	Subtype	PubMed ID
esv2740170	CNV	Deletion	23290073
nsv7446	OTHER	Inversion	18451855

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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2 diseases for XAGE5:
About MalaCards

melanoma sarcoma

XAGE5 for disorders About GeneDecksing

Export disorders for XAGE5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for XAGE5 gene integrated from 10 sources:
(articles sorted by number of sources associating them with XAGE5)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (Nature 2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PubMed id 11992404)^{1, 2} Zendman A.J.W....van Muijen G.N.P. (Int. J. Cancer 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 170627	HGNC: 30930	AceView: GAGED5	Ensembl:ENSG00000171405	euGenes: HUgn170627
ECgene: XAGE5	H-InvDB: XAGE5

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for XAGE5	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for XAGE5	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for XAGE5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for XAGE5 gene:
Search GeneIP for patents involving XAGE5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes XAGE5 gene at Home site.

Version: 3.12.142 28 July 2014
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XAGE5 Gene

X Antigen Family, Member 5

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XAGE5 Human Recombinant Protein Products:

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Export list of displayed genes

XAGE5 Gene

X Antigen Family, Member 5

Aliasesfor XAGE5 gene

Summariesfor XAGE5 gene

Genomic Viewsfor XAGE5 gene

Proteinsfor XAGE5 gene

XAGE5 Human Recombinant Protein Products:

XAGE5 Antibody Products:

XAGE5 Assay Products:

Domains /Familiesfor XAGE5 gene

Functionfor XAGE5 gene

Localizationfor XAGE5 gene

Pathways & Interactionsfor XAGE5 gene

Drugs & Compoundsfor XAGE5 gene

Transcriptsfor XAGE5 gene

Expression for XAGE5 gene

Orthologsfor XAGE5 gene

Paralogsfor XAGE5 gene

Genomic Variantsfor XAGE5 gene

Disorders / Diseasesfor XAGE5 gene

Publicationsfor XAGE5 gene

External Searches for XAGE5 gene

Genome Databases showing XAGE5 gene

Other Databases showing XAGE5 gene

Specialized Databases showing XAGE5 gene

Intellectual Propertyfor XAGE5 gene

Productsfor XAGE5 gene

View Random Gene

Aliases
for XAGE5 gene

Summaries
for XAGE5 gene

Genomic Views
for XAGE5 gene

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for XAGE5 gene

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Families
for XAGE5 gene

Function
for XAGE5 gene

Localization
for XAGE5 gene

Pathways & Interactions
for XAGE5 gene

Drugs & Compounds
for XAGE5 gene

Transcripts
for XAGE5 gene

Expression
for XAGE5 gene

Orthologs
for XAGE5 gene

Paralogs
for XAGE5 gene

Genomic Variants
for XAGE5 gene

Disorders / Diseases
for XAGE5 gene

Publications
for XAGE5 gene

Intellectual Property
for XAGE5 gene

Products
for XAGE5 gene