Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Plus
- Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

XAGE3 Gene

protein-coding GIFtS: 40
GCID: GC0XM052908

X Antigen Family, Member 3

(Previous names: placenta-specific 6; G antigen, family D, 4)
(Previous symbols: PLAC6, GAGED4)

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

TryGeneCards Plus

Aliases
X Antigen Family, Member 3¹ ²		Placenta-Specific 6; G Antigen, Family D, 4¹
PLAC6¹ ² ³ ⁵		CT12.3a²
GAGED4¹ ² ³		CT12.3b²
Cancer/Testis Antigen 12.3² ³		Cancer/Testis Antigen Family 12, Member 3a²
G Antigen Family D Member 4² ³		Cancer/Testis Antigen Family 12, Member 3b²
Placenta-Specific Gene 6 Protein² ³		G Antigen, Family D, 4²
CT12.3² ³		Placenta-Specific 6²
XAGE-3² ³		pp9012²
Cancer/Testis Antigen Family 12¹		Protein XAGE-3²
Member 3a¹		X Antigen Family Member 3²
Member 3b¹

External Ids:	HGNC: 14618¹	Entrez Gene: 170626²	Ensembl: ENSG00000171402⁷	OMIM: 300740⁵	UniProtKB: Q8WTP9³

Export aliases for XAGE3 gene to outside databases

Previous GC identifer: GC0XM052775

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for XAGE3 Gene:

This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a

variety of tumors and in some fetal and reproductive tissues. This gene is expressed in placenta and fetal

liver/spleen, and may function in inhibiting cancer cell growth. The protein encoded by this gene shares a

sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity,

this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene generates

2 transcript variants differing in the 5' UTR. (provided by RefSeq, Jul 2008)

GeneCards Summary for XAGE3 Gene:

XAGE3 (X antigen family, member 3) is a protein-coding gene. Diseases associated with XAGE3 include sarcoma, and melanoma. An important paralog of this gene is GAGE2D.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus

RefSeq DNA sequence:

NC_000023.11 NC_018934.2 NT_011630.15

Regulatory elements:

Search for regulatory transcription factor binding sites for XAGE3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: XAGE3 promoter sequence

Search Chromatin IP Primers for XAGE3

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat XAGE3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.22 Ensembl cytogenetic band: Xp11.22 HGNC cytogenetic band: Xp11.22

XAGE3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XAGE3 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM052908: view genomic region (about GC identifiers)

Start:	52,891,557 bp from pter	End:	52,897,119 bp from pter
Size:	5,563 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: XAGE3_HUMAN, Q8WTP9 (See protein sequence)

Recommended Name: X antigen family member 3

Size: 111 amino acids; 12302 Da

Secondary accessions: Q5JS82 Q8WYS9

Explore the universe of human proteins at neXtProt for XAGE3: NX_Q8WTP9

Explore proteomics data for XAGE3 at MOPED

See XAGE3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_570132.1 NP_573440.1

ENSEMBL proteins:

ENSP00000364640 ENSP00000303061

XAGE3 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for XAGE3 OriGene Custom MassSpec OriGene Custom Protein Services for XAGE3
	GenScript Custom Purified and Recombinant Proteins Services for XAGE3
	Novus Biologicals XAGE3 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for XAGE3

XAGE3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for XAGE3
	Novus Biologicals XAGE3 Antibody
	Search for Antibodies for XAGE3 at Abcam
	Cloud-Clone Corp. Antibodies for XAGE3
	Search ThermoFisher Antibodies for XAGE3
	Search LSBio for Antibodies for XAGE3

XAGE3 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for XAGE3
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for XAGE3
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for XAGE3 Cloud-Clone Corp. CLIAs for XAGE3

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus

1 InterPro protein domain:

IPR008625 GAGE

Graphical View of Domain Structure for InterPro Entry Q8WTP9

ProtoNet protein and cluster: Q8WTP9

1 Blocks protein domain: IPB008625 GAGE

UniProtKB/Swiss-Prot: XAGE3_HUMAN, Q8WTP9

Similarity: Belongs to the GAGE family

XAGE3 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--

XAGE3 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for XAGE3:

Increased gamma-H2AX phosphory

Synthetic lethal with Ras

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for XAGE3

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for XAGE3

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for XAGE3

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for XAGE3

miRNA Products:		Block miRNA regulation of human, mouse, rat XAGE3 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate XAGE3
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for XAGE3
		Predesigned siRNA for gene silencing in human, mouse, rat XAGE3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for XAGE3

Clone Products:		OriGene clones in human, mouse for XAGE3 (see all 9) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): XAGE3 (NM_133179)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for XAGE3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XAGE3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for XAGE3
		Browse ESI BIO Cell Lines and PureStem Progenitors for XAGE3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XAGE3

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
mitochondrion	3
nucleus	2

About this image

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for XAGE3
Interactions:

Search GeneGlobe Interaction Network for XAGE3

1 Interacting protein for XAGE3 (Q8WTP9¹) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HTT	P42858¹	EBI-6448284,EBI-466029

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for XAGE3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for XAGE3 gene (2 alternative transcripts):

NM_130776.1 NM_133179.2

Unigene Cluster for XAGE3:

X antigen family, member 3

Hs.43879 [show with all ESTs]

Unigene Representative Sequence: CF993800

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000375491(uc004dre.3) ENST00000346279(uc004drf.3)

miRNA Products:		Block miRNA regulation of human, mouse, rat XAGE3 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate XAGE3
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for XAGE3
		Predesigned siRNA for gene silencing in human, mouse, rat XAGE3

Clone Products:		OriGene clones in human, mouse for XAGE3 (see all 9) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): XAGE3 (NM_133179)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for XAGE3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XAGE3

Primer Products:		OriGene qPCR primer pairs and template standards for XAGE3 OriGene qSTAR qPCR primer pairs in human, mouse for XAGE3
		Pre-validated RT² qPCR Primer Assay in human, mouse / rat XAGE3
		QuantiTect SYBR Green Assays in human, mouse, rat XAGE3
		QuantiFast Probe-based Assays in human, mouse, rat XAGE3

Additional mRNA sequence:

AF318372.1 AJ318881.1 BC062680.1

3 DOTS entries:

DT.101970658 DT.97825141 DT.410605

24 AceView cDNA sequences:

AJ318881 NM_130776 N32547 N41436 BC062680 N41892 AI189067 NM_133179

C18417 CF993800 BG354572 D59091 AF318372 BX283272 AI742551 N40147

T84951 BG436468 N41723 CB994958 CB992682 CB961487 BG436305 BG435916

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

XAGE3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

XAGE3 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

XAGE3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.43879

Custom PCR Arrays for XAGE3

Primer Products:		OriGene qPCR primer pairs and template standards for XAGE3 OriGene qSTAR qPCR primer pairs in human, mouse for XAGE3
		Pre-validated RT² qPCR Primer Assay in human, mouse / rat XAGE3
		QuantiTect SYBR Green Assays in human, mouse, rat XAGE3
		QuantiFast Probe-based Assays in human, mouse, rat XAGE3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XAGE3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of human and chimp.

Orthologs for XAGE3 gene from 1 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chimpanzee (Pan troglodytes)	Mammalia	XAGE3¹	X antigen family, member 3	99.1(n) 99.1(a)		741714 XM_001144042.1 XP_001144042.1

ENSEMBL Gene Tree for XAGE3 (if available)
TreeFam Gene Tree for XAGE3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

TryGeneCards Plus

Paralogs for XAGE3 gene

GAGE2D² GAGE12H² GAGE10² GAGE12I² XAGE5² XAGE2B² GAGE12C² GAGE12E²

GAGE12D² GAGE2E² GAGE1² GAGE2C² GAGE12F² GAGE13² PAGE1² XAGE2²

GAGE12G² GAGE2B² GAGE2A² GAGE12J²

Selected SIMAP similar genes for XAGE3 using alignment to 2 protein entries: XAGE3_HUMAN (see all proteins) (see all similar genes):

XAGE2 XAGE2B XAGE1A XAGE1B XAGE1C XAGE1D

XAGE1E XAGE5 XAGE-4 PAGE3 GAGE2D GAGE8

GAGE2A GAGE2B GAGE2C GAGE2E GAGE1 GAGE10

XAGE3 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for XAGE3
PGOHUM00000245809 PGOHUM00000241340

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112309777^1,2	C	--	52891142(+)	`TGTGTG/ATACCA`	2	--	ds500¹		1		WA	2
rs145496669^1,2		--	52891144(+)	`TGTGTA/GCCAGT`	2	--	ds500¹		0	--	--	--	--
rs189096607^1,2		--	52891154(+)	`TGTAAC/TCAGAA`	2	--	ds500¹		0	--	--	--	--
rs113929255^1,2	C	--	52891162(+)	`GAATAC/GAAAAT`	2	--	ds500¹		0	--	--	--	--
rs36178708^1,2	C	--	52891170(+)	`AATTTC/TAAAAA`	2	--	ds500¹		0	--	--	--	--
rs370449451^1,2	C	--	52891192(+)	`CCTTT-/CTTTTT`	2	--	ds500¹		0	--	--	--	--
rs144497294^1,2	C	--	52891213(+)	`TCTCA-/CTCTGTC`	2	--	ds500¹		0	--	--	--	--
rs112002658^1,2	C	--	52891259(+)	`TACCTG/ACATCC`	2	--	ds500¹		1		WA	2
rs181557873^1,2		--	52891304(+)	`AGCCTC/TAGGAG`	2	--	ds500¹		0	--	--	--	--
rs73206485^1,2	C	--	52891331(+)	`TACATA/GTATAC`	2	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for XAGE3 (52891557 - 52897119 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for XAGE3: About this table

Variant ID	Type	Subtype	PubMed ID
esv2740175	CNV	Deletion	23290073
nsv435891	CNV	Deletion	17901297
esv2740170	CNV	Deletion	23290073

Site Specific Mutation Identification with PCR Assays

Search QIAGEN SeqTarget long-range PCR primers for resequencing XAGE3

DNA2.0 Custom Variant and Variant Library Synthesis for XAGE3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus

OMIM gene information: 300740 OMIM disorders: --

2 diseases for XAGE3:
About MalaCards

sarcoma melanoma

XAGE3 for disorders About GeneDecksing

Export disorders for XAGE3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for XAGE3 gene integrated from 10 sources:
(articles sorted by number of sources associating them with XAGE3)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (Nature 2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)^{1, 2} Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PubMed id 11992404)^{1, 2} Zendman A.J.W....van Muijen G.N.P. (Int. J. Cancer 2002)
Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)¹ Suter B....Wanker E.E. (Nucleic Acids Res. 2013)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (Genomics 2007)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database. (PubMed id 10197611)¹ Brinkmann U.... Pastan I. (Cancer Res. 1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus

Entrez Gene: 170626	HGNC: 14618	AceView: GAGED4	Ensembl:ENSG00000171402	euGenes: HUgn170626
ECgene: XAGE3	H-InvDB: XAGE3

(According to HUGE)
About This Section

TryGeneCards Plus

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus

Name	Description
PharmGKB entry for XAGE3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for XAGE3	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for XAGE3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

TryGeneCards Plus

Patent Information for XAGE3 gene:
Search GeneIP for patents involving XAGE3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus


	EMD Millipore genomic analysis products

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Recombinant/Natural Proteins		Browse Stem Cell Products
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for XAGE3
	OriGene qPCR primer pairs and template standards for XAGE3		OriGene Protein Over-expression Lysate for XAGE3
	OriGene Custom Mass Spec		OriGene clones in human, mouse for XAGE3
	OriGene qSTAR qPCR primer pairs in human, mouse for XAGE3		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	Browse OriGene ORF clones		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for XAGE3		OriGene Custom Protein Services for XAGE3

	Block miRNA regulation of human, mouse, rat XAGE3 using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing XAGE3
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat XAGE3		Predesigned siRNA for gene silencing in human, mouse, rat XAGE3
	QuantiFast Probe-based Assays in human, mouse, rat XAGE3		QuantiTect SYBR Green Assays in human, mouse, rat XAGE3
	Custom PCR Arrays for XAGE3		Search Chromatin IP Primers for XAGE3
	Pre-validated RT² qPCR Primer Assay in human, mouse / rat XAGE3		Search GeneGlobe Interaction Network for XAGE3
	Search Regulatory tfbs for XAGE3

	GenScript Custom Purified and Recombinant Proteins Services for XAGE3		GenScript cDNA clones with any tag delivered in your preferred vector for XAGE3
	GenScript Custom Assay Services for XAGE3		GenScript Custom overexpressing Cell Line Services for XAGE3
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

Search Tocris compounds for XAGE3

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	XAGE3 antibodies
	XAGE3 lysates

	Search for Antibodies for XAGE3 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for XAGE3
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for XAGE3
	Antibodies for XAGE3
	ELISAs for XAGE3
	CLIAs for XAGE3

Browse ESI BIO Cell Lines and PureStem Progenitors for XAGE3

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XAGE3

	Browse SwitchGear 3'UTR luciferase reporter plasmids for XAGE3
	SwitchGear Promoter luciferase reporter plasmids for XAGE3

Search ThermoFisher Antibodies for XAGE3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XAGE3

	inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for XAGE3
	inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for XAGE3

Search LSBio for Antibodies for XAGE3

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

Browse compounds at ApexBio

GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes XAGE3 gene at Home site.

Version: 3.12.142 28 July 2014
hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4

GeneCards Plus

Advanced Search

Export list of displayed genes

XAGE3 Gene

X Antigen Family, Member 3

Aliases
for XAGE3 gene

Summaries
for XAGE3 gene

Genomic Views
for XAGE3 gene

Proteins
for XAGE3 gene

XAGE3 Human Recombinant Protein Products:

XAGE3 Antibody Products:

XAGE3 Assay Products:

Domains /
Families
for XAGE3 gene

Function
for XAGE3 gene

Localization
for XAGE3 gene

Pathways & Interactions
for XAGE3 gene

Drugs & Compounds
for XAGE3 gene

Transcripts
for XAGE3 gene

Expression
for XAGE3 gene

Orthologs
for XAGE3 gene

Paralogs
for XAGE3 gene

Genomic Variants
for XAGE3 gene

Disorders / Diseases
for XAGE3 gene

Publications
for XAGE3 gene

External Searches for XAGE3 gene

Genome Databases showing XAGE3 gene

Other Databases showing XAGE3 gene

Specialized Databases showing XAGE3 gene

Intellectual Property
for XAGE3 gene

Products
for XAGE3 gene

View Random Gene

XAGE3 (Gene Symbol)
X Antigen Family, Member 3
PLAC6
GAGED4
Cancer/Testis Antigen 12.3
G Antigen Family D Member 4
Placenta-Specific Gene 6 Protein
CT12.3
XAGE-3
Cancer/Testis Antigen Family 12
Member 3a
Member 3b
Placenta-Specific 6; G Antigen, Family D, 4
CT12.3a
CT12.3b
Cancer/Testis Antigen Family 12, Member 3a
Cancer/Testis Antigen Family 12, Member 3b
G Antigen, Family D, 4
Placenta-Specific 6
pp9012
Protein XAGE-3
X Antigen Family Member 3

GeneCards Plus

Advanced Search

Export list of displayed genes

XAGE3 Gene

X Antigen Family, Member 3

Aliasesfor XAGE3 gene

Summariesfor XAGE3 gene

Genomic Viewsfor XAGE3 gene

Proteinsfor XAGE3 gene

XAGE3 Human Recombinant Protein Products:

XAGE3 Antibody Products:

XAGE3 Assay Products:

Domains /Familiesfor XAGE3 gene

Functionfor XAGE3 gene

Localizationfor XAGE3 gene

Pathways & Interactionsfor XAGE3 gene

Drugs & Compoundsfor XAGE3 gene

Transcriptsfor XAGE3 gene

Expression for XAGE3 gene

Orthologsfor XAGE3 gene

Paralogsfor XAGE3 gene

Genomic Variantsfor XAGE3 gene

Disorders / Diseasesfor XAGE3 gene

Publicationsfor XAGE3 gene

External Searches for XAGE3 gene

Genome Databases showing XAGE3 gene

Other Databases showing XAGE3 gene

Specialized Databases showing XAGE3 gene

Intellectual Propertyfor XAGE3 gene

Productsfor XAGE3 gene

View Random Gene

Aliases
for XAGE3 gene

Summaries
for XAGE3 gene

Genomic Views
for XAGE3 gene

Proteins
for XAGE3 gene

Domains /
Families
for XAGE3 gene

Function
for XAGE3 gene

Localization
for XAGE3 gene

Pathways & Interactions
for XAGE3 gene

Drugs & Compounds
for XAGE3 gene

Transcripts
for XAGE3 gene

Expression
for XAGE3 gene

Orthologs
for XAGE3 gene

Paralogs
for XAGE3 gene

Genomic Variants
for XAGE3 gene

Disorders / Diseases
for XAGE3 gene

Publications
for XAGE3 gene

Intellectual Property
for XAGE3 gene

Products
for XAGE3 gene