XAGE3 Gene

Aliases
for XAGE3 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifer: GC0XM052775

Summaries
for XAGE3 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for XAGE3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000023.10  NC_018934.2  NT_011630.15  

SwitchGear Promoter luciferase reporter plasmid: XAGE3 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat XAGE3

XAGE3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM052908:  view genomic region     (about GC identifiers)

Proteins
for XAGE3 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for XAGE3: NX_Q8WTP9

Explore proteomics data for XAGE3 at MOPED


See XAGE3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

XAGE3 Human Recombinant Protein Products:

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	Novus Biologicals XAGE3 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
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	Cloud-Clone Corp. Proteins for XAGE3
	Search eBioscience for Proteins for XAGE3
	Search GeneTex for Proteins for XAGE3
	antibodies-online proteins for XAGE3
	Search antibodies-online for peptides for XAGE3

XAGE3 Antibody Products:

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	Novus Biologicals XAGE3 Antibody
	Search for Antibodies for XAGE3 at Abcam
	Cloud-Clone Corp. Antibodies for XAGE3
	Search ThermoFisher Antibodies for XAGE3
	Search antibodies-online for antibodies for XAGE3

XAGE3 Assay Products:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for XAGE3
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for XAGE3 Cloud-Clone Corp. CLIAs for XAGE3
	Search eBioscience for ELISAs for XAGE3
	antibodies-online kits for XAGE3 (2 products)

Domains /
Families
for XAGE3 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q8WTP9

Find genes that share domains with XAGE3           About GenesLikeMe

Function
for XAGE3 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 1 molecular function term:    About this table

genOway: Develop your customized and physiologically relevant rodent model for XAGE3

miRNA Products:		Block miRNA regulation of human, mouse, rat XAGE3 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate XAGE3
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for XAGE3
		Predesigned siRNA for gene silencing in human, mouse, rat XAGE3

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for XAGE3

Clone Products:		OriGene clones in human, mouse for XAGE3 (see all 9) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): XAGE3 (NM_133179)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for XAGE3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XAGE3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for XAGE3
		Browse ESI BIO Cell Lines and PureStem Progenitors for XAGE3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XAGE3

Localization
for XAGE3 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Pathways & Interactions
for XAGE3 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Drugs & Compounds
for XAGE3 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for XAGE3 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for XAGE3 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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XAGE3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

Primer Products:		OriGene qPCR primer pairs and template standards for XAGE3 OriGene qSTAR qPCR primer pairs in human, mouse for XAGE3
		Pre-validated RT2 qPCR Primer Assay in human, mouse / rat XAGE3
		QuantiTect SYBR Green Assays in human, mouse, rat XAGE3
		QuantiFast Probe-based Assays in human, mouse, rat XAGE3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XAGE3

Orthologs
for XAGE3 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for XAGE3 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for XAGE3 gene

GAGE2D²  GAGE12H²  GAGE10²  GAGE12I²  XAGE5²  XAGE2B²  GAGE12C²  GAGE12E²  

GAGE12D²  GAGE2E²  GAGE1²  GAGE2C²  GAGE12F²  GAGE13²  PAGE1²  XAGE2²  

GAGE12G²  GAGE2B²  GAGE2A²  GAGE12J²  

Selected SIMAP similar genes for XAGE3 using alignment to 2 protein entries:     XAGE3_HUMAN (see all proteins) (see all similar genes):

XAGE2    XAGE2B    XAGE1A    XAGE1B    XAGE1C    XAGE1D

XAGE1E    XAGE5    XAGE-4    PAGE3    GAGE2D    GAGE8

GAGE2A    GAGE2B    GAGE2C    GAGE2E    GAGE1    GAGE10

Find genes that share paralogs with XAGE3           About GenesLikeMe


2 Pseudogenes.org Pseudogenes for XAGE3
PGOHUM00000245809 PGOHUM00000241340

Genomic Variants
for XAGE3 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for XAGE3 (see all 172)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1123097771,2	C	--	52891142(+)	TGTGTG/ATACCA	2	--	ds5001		1		WA	2
rs1454966691,2		--	52891144(+)	TGTGTA/GCCAGT	2	--	ds5001		0	--	--	--	--
rs1890966071,2		--	52891154(+)	TGTAAC/TCAGAA	2	--	ds5001		0	--	--	--	--
rs1139292551,2	C	--	52891162(+)	GAATAC/GAAAAT	2	--	ds5001		0	--	--	--	--
rs361787081,2	C	--	52891170(+)	AATTTC/TAAAAA	2	--	ds5001		0	--	--	--	--
rs3704494511,2	C	--	52891192(+)	CCTTT-/CTTTTT	2	--	ds5001		0	--	--	--	--
rs1444972941,2	C	--	52891213(+)	TCTCA-/CTCTGTC	2	--	ds5001		0	--	--	--	--
rs1120026581,2	C	--	52891259(+)	TACCTG/ACATCC	2	--	ds5001		1		WA	2
rs1815578731,2		--	52891304(+)	AGCCTC/TAGGAG	2	--	ds5001		0	--	--	--	--
rs732064851,2	C	--	52891331(+)	TACATA/GTATAC	2	--	ds5001		0	--	--	--	--

HapMap Linkage Disequilibrium report for XAGE3 (52891557 - 52897119 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for XAGE3:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2740175	CNV	Deletion	23290073
nsv435891	CNV	Deletion	17901297
esv2740170	CNV	Deletion	23290073

Site Specific Mutation Identification with PCR Assays

Search QIAGEN SeqTarget long-range PCR primers for resequencing XAGE3

DNA2.0 Custom Variant and Variant Library Synthesis for XAGE3

Disorders / Diseases
for XAGE3 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for XAGE3 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (Nature 2005)
2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)^{1, 2} Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
4. The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PubMed id 11992404)^{1, 2} Zendman A.J.W....van Muijen G.N.P. (Int. J. Cancer 2002)
5. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)¹ Suter B....Wanker E.E. (Nucleic Acids Res. 2013)
6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (Genomics 2007)
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
8. Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database. (PubMed id 10197611)¹ Brinkmann U.... Pastan I. (Cancer Res. 1999)

External Searches for XAGE3 gene

Genome Databases showing XAGE3 gene

Other Databases showing XAGE3 gene

Specialized Databases showing XAGE3 gene

Products
for XAGE3 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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