XAGE3 Gene
protein-coding GIFtS: 41
GCID: GC0XM052908
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X antigen family, member 3(Previous names: placenta-specific 6; G antigen, family D, 4 )
(Previous symbols: PLAC6, GAGED4)
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Aliases
for XAGE3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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| Aliases |
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| X Antigen Family, Member 31 2 | | Protein XAGE-32 3 | | PLAC61 2 3 5 | | CT12.32 3 | | GAGED41 2 3 | | Placenta-Specific 6; G Antigen, Family D, 41 | | CT12.3a1 2 | | Cancer/Testis Antigen Family 12, Member 3a2 | | CT12.3b1 2 | | Cancer/Testis Antigen Family 12, Member 3b2 | | XAGE-31 2 | | G Antigen Family D Member 42 | | Pp90121 | | G Antigen, Family D, 42 | | Cancer/Testis Antigen 12.32 3 | | Placenta-Specific 62 | | Placenta-Specific Gene 6 Protein2 3 | | |
Export aliases for XAGE3 gene to outside databasesPrevious GC identifer: GC0XM052775 |
Summaries
for XAGE3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for XAGE3:
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in avariety of tumors and in some fetal and reproductive tissues. This gene is expressed in placenta and fetalliver/spleen, and may function in inhibiting cancer cell growth. The protein encoded by this gene shares a sequencesimilarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this proteinalso belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene generates 2 transcriptvariants differing in the 5' UTR. (provided by RefSeq, Jul 2008)
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Genomic Views
for XAGE3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011630.14
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for XAGE3
Other transcription factors
Search SABiosciences Chromatin IP Primers for XAGE3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XAGE3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.22 Ensembl cytogenetic band: Xp11.22 HGNC cytogenetic band: Xp11.22XAGE3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM052908: view genomic region
(about GC identifiers)
Start:
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52,891,557 bp from pter |
End:
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52,897,119 bp from pter |
Size:
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5,563 bases |
Orientation:
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minus strand |
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Proteins
for XAGE3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GAGD4_HUMAN, Q8WTP9 (See
protein sequence)Recommended Name: G antigen family D member 4 Size: 111 amino acids; 12302 Da
Secondary accessions: Q5JS82 Q8WYS9Explore the universe of human proteins at neXtProt for XAGE3: NX_Q8WTP9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WTP9
XAGE3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_570132.1 NP_573440.1
ENSEMBL proteins: ENSP00000364640 ENSP00000303061
Human Recombinant Protein Products:
XAGE3 Antibody Products:
Assay Products for XAGE3: |
Protein
Domains /
Families
for XAGE3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
XAGE3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8WTP9ProtoNet protein and cluster: Q8WTP9 1 Blocks protein family: IPB008625 GAGE
UniProtKB/Swiss-Prot: GAGD4_HUMAN, Q8WTP9Similarity: Belongs to the GAGE family |
Function
for XAGE3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XAGE3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XAGE3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): XAGE3 (NM_133179) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XAGE3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XAGE3 |
2 GenomeRNAi human phenotypes for XAGE3:
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Pathways & Interactions
for XAGE3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for XAGE3
1 Interacting protein for XAGE3 (Q8WTP91) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for XAGE3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for XAGE3
Search CenterWatch for drugs/clinical trials and news about XAGE3 / GAGD4
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Transcripts
for XAGE3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for XAGE3 gene (2 alternative transcripts): NM_130776.1 NM_133179.2 Unigene Cluster for XAGE3: X antigen family, member 3 Hs.43879 [show with all ESTs]Unigene Representative Sequence: CF9938002 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000375491(uc004dre.3) ENST00000346279(uc004drf.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XAGE3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XAGE3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): XAGE3 (NM_133179) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XAGE3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XAGE3 |
Additional cDNA sequence: AF318372.1 AJ318881.1 BC062680.1 3 DOTS entries: DT.101970658 DT.97825141 DT.410605 24 AceView cDNA sequences: NM_130776 AJ318881 N32547 AI189067 NM_133179 BC062680 N41436 N41892 BG354572 BX283272 AF318372 C18417 CF993800 D59091 AI742551 N40147 T84951 N41723 BG436468 CB994958 CB992682 CB961487 BG436305 BG435916
GeneLoc Exon Structure
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Expression
for XAGE3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| XAGE3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See XAGE3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for XAGE3
SOURCE GeneReport for Unigene cluster: Hs.43879
SABiosciences Custom PCR Arrays for XAGE3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XAGE3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat XAGE3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XAGE3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XAGE3 |
Orthologs
for XAGE3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for XAGE3 (if available)
TreeFam Gene Tree for XAGE3 (if available) |
Paralogs
for XAGE3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for XAGE3 gene
- PAGE22 GAGE2D2 GAGE42 GAGE102 GAGE12H2 GAGE12I2 PAGE32 XAGE52
- XAGE2B2 PAGE52 GAGE12C2 GAGE12E2 GAGE12D2 PAGE2B2 GAGE12 GAGE2E2
- GAGE2C2 GAGE12F2 PAGE12 GAGE132 XAGE22 GAGE12G2 GAGE2A2 GAGE2B2
- PAGE42 GAGE12J2
18/38 SIMAP similar genes for XAGE3 using alignment to 2 protein entries: GAGD4_HUMAN (see all proteins)
(see all similar genes):XAGE2 XAGE2B XAGE1A XAGE1B XAGE1C XAGE1D
XAGE1E XAGE5 XAGE-4 PAGE3 GAGE2D GAGE8
GAGE2A GAGE2B GAGE2C GAGE2E GAGE1 GAGE10
XAGE3 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for XAGE3
PGOHUM00000245809 PGOHUM00000241340
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Genomic Variants
for XAGE3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for XAGE3 (52891557 - 52897119 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for XAGE3
1 CNV: 23256 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for XAGE3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
XAGE3 for disorders About GeneDecksing
OMIM gene information: 300740
OMIM disorders: --
2  diseases for XAGE3: About MalaCardssarcoma melanoma
Export disorders for XAGE3 gene to outside databases
|
Publications
for XAGE3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for XAGE3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with XAGE3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
- The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PubMed id 11992404)1, 2 Zendman A.J.W....van Muijen G.N.P. (2002)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database. (PubMed id 10197611)1 Brinkmann U.... Pastan I. (1999)
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External Searches for XAGE3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing XAGE3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing XAGE3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing XAGE3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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About This Section
| Patent Information for XAGE3 gene:
Search GeneIP for patents involving XAGE3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for XAGE3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for XAGE3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for XAGE3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XAGE3 | | | OriGene Protein Over-expression Lysate for XAGE3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for XAGE3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XAGE3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XAGE3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat XAGE3 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XAGE3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XAGE3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XAGE3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XAGE3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XAGE3 |
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| | | | Search Tocris compounds for XAGE3 |
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 | | | XAGE3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for XAGE3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XAGE3 |
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