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Aliases for XAGE3 Gene

Aliases for XAGE3 Gene

  • X Antigen Family Member 3 2 3 5
  • Cancer/Testis Antigen Family 12, Member 3a 2 3
  • Cancer/Testis Antigen Family 12, Member 3b 2 3
  • Placenta-Specific Gene 6 Protein 3 4
  • G Antigen Family D Member 4 3 4
  • Cancer/Testis Antigen 12.3 3 4
  • GAGED4 3 4
  • CT12.3 3 4
  • XAGE-3 3 4
  • PLAC6 3 4
  • Placenta-Specific 6; G Antigen, Family D, 4 2
  • X Antigen Family, Member 3 2
  • G Antigen, Family D, 4 3
  • Placenta-Specific 6 3
  • Protein XAGE-3 3
  • CT12.3a 3
  • CT12.3b 3
  • Pp9012 3

External Ids for XAGE3 Gene

Previous HGNC Symbols for XAGE3 Gene

  • PLAC6
  • GAGED4

Previous GeneCards Identifiers for XAGE3 Gene

  • GC0XM052775

Summaries for XAGE3 Gene

Entrez Gene Summary for XAGE3 Gene

  • This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is expressed in placenta and fetal liver/spleen, and may function in inhibiting cancer cell growth. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene generates 2 transcript variants differing in the 5' UTR. [provided by RefSeq, Jul 2008]

GeneCards Summary for XAGE3 Gene

XAGE3 (X Antigen Family Member 3) is a Protein Coding gene. An important paralog of this gene is XAGE5.

Additional gene information for XAGE3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XAGE3 Gene

Genomics for XAGE3 Gene

GeneHancer (GH) Regulatory Elements for XAGE3 Gene

Promoters and enhancers for XAGE3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI052868 Promoter 0.6 EPDnew 550.8 +0.0 32 0.1 NRF1 XAGE3 EIF4A2P4
GH0XI052851 Enhancer 0.5 Ensembl ENCODE 0.4 +15.4 15377 2.7 SPI1 FAM156A XAGE3 EIF4A2P4
GH0XI052864 Enhancer 0.2 ENCODE 0.8 +2.6 2643 1.8 XAGE3 EIF4A2P4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around XAGE3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for XAGE3 Gene

Genomic Locations for XAGE3 Gene
5,611 bases
Minus strand

Genomic View for XAGE3 Gene

Genes around XAGE3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XAGE3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XAGE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XAGE3 Gene

Proteins for XAGE3 Gene

  • Protein details for XAGE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    X antigen family member 3
    Protein Accession:
    Secondary Accessions:
    • Q5JS82
    • Q8WYS9

    Protein attributes for XAGE3 Gene

    111 amino acids
    Molecular mass:
    12302 Da
    Quaternary structure:
    No Data Available

neXtProt entry for XAGE3 Gene

Post-translational modifications for XAGE3 Gene

No Post-translational modifications

Other Protein References for XAGE3 Gene

No data available for DME Specific Peptides for XAGE3 Gene

Domains & Families for XAGE3 Gene

Gene Families for XAGE3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for XAGE3 Gene


Suggested Antigen Peptide Sequences for XAGE3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GAGE family.
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with XAGE3: view

Function for XAGE3 Gene

Phenotypes From GWAS Catalog for XAGE3 Gene

Gene Ontology (GO) - Molecular Function for XAGE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23275563
genes like me logo Genes that share ontologies with XAGE3: view
genes like me logo Genes that share phenotypes with XAGE3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for XAGE3 Gene

Localization for XAGE3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for XAGE3 gene
Compartment Confidence
mitochondrion 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for XAGE3 Gene

Pathways & Interactions for XAGE3 Gene

SuperPathways for XAGE3 Gene

No Data Available

Interacting Proteins for XAGE3 Gene

Gene Ontology (GO) - Biological Process for XAGE3 Gene


No data available for Pathways by source and SIGNOR curated interactions for XAGE3 Gene

Drugs & Compounds for XAGE3 Gene

No Compound Related Data Available

Transcripts for XAGE3 Gene

mRNA/cDNA for XAGE3 Gene

Unigene Clusters for XAGE3 Gene

X antigen family, member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for XAGE3 Gene

No ASD Table

Relevant External Links for XAGE3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for XAGE3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for XAGE3 Gene

mRNA differential expression in normal tissues according to GTEx for XAGE3 Gene

This gene is overexpressed in Testis (x25.5), Breast - Mammary Tissue (x7.3), Liver (x6.2), and Adipose - Subcutaneous (x5.5).

NURSA nuclear receptor signaling pathways regulating expression of XAGE3 Gene:


SOURCE GeneReport for Unigene cluster for XAGE3 Gene:

genes like me logo Genes that share expression patterns with XAGE3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for XAGE3 Gene

Orthologs for XAGE3 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for XAGE3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia XAGE3 33 34
  • 99.1 (n)
Species where no ortholog for XAGE3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for XAGE3 Gene

Gene Tree for XAGE3 (if available)
Gene Tree for XAGE3 (if available)

Paralogs for XAGE3 Gene

Paralogs for XAGE3 Gene Pseudogenes for XAGE3 Gene

genes like me logo Genes that share paralogs with XAGE3: view

Variants for XAGE3 Gene

Sequence variations from dbSNP and Humsavar for XAGE3 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1007957187 -- 52,862,461(-) C/A downstream_transcript_variant
rs1014774726 -- 52,862,864(-) T/C intron_variant
rs1019438059 -- 52,862,063(-) G/A downstream_transcript_variant
rs1019892743 -- 52,862,485(-) C/A downstream_transcript_variant
rs1023014799 -- 52,862,867(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for XAGE3 Gene

Variant ID Type Subtype PubMed ID
esv2740170 CNV deletion 23290073
esv2740175 CNV deletion 23290073
esv3576877 CNV gain 25503493
nsv435891 CNV deletion 17901297

Variation tolerance for XAGE3 Gene

Residual Variation Intolerance Score: 50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for XAGE3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XAGE3 Gene

Disorders for XAGE3 Gene

Additional Disease Information for XAGE3

No disorders were found for XAGE3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XAGE3 Gene

Publications for XAGE3 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  4. The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PMID: 11992404) Zendman AJ … Van Muijen GN (International journal of cancer 2002) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for XAGE3 Gene

Sources for XAGE3 Gene

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