Aliases for XAGE3 Gene
Aliases for XAGE3 Gene
External Ids for XAGE3 Gene
- HGNC: 14618
- Entrez Gene: 170626
- Ensembl: ENSG00000171402
- OMIM: 300740
- UniProtKB: Q8WTP9
Previous HGNC Symbols for XAGE3 Gene
- PLAC6
- GAGED4
Previous GeneCards Identifiers for XAGE3 Gene
- GC0XM052775
Summaries for XAGE3 Gene
-
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is expressed in placenta and fetal liver/spleen, and may function in inhibiting cancer cell growth. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene generates 2 transcript variants differing in the 5' UTR. [provided by RefSeq, Jul 2008]
GeneCards Summary for XAGE3 Gene
XAGE3 (X Antigen Family Member 3) is a Protein Coding gene. An important paralog of this gene is XAGE5.
Additional gene information for XAGE3 Gene
- Monarch Initiative
- Search for XAGE3 at DataMed
- Search for XAGE3 at HumanCyc
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XAGE3 Gene
Genomics for XAGE3 Gene
GeneHancer (GH) Regulatory Elements for XAGE3 Gene
Promoters and enhancers for XAGE3 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH0XI052868 | Promoter | 0.6 | EPDnew | 550.8 | +0.0 | 32 | 0.1 | NRF1 | XAGE3 EIF4A2P4 | |
| GH0XI052851 | Enhancer | 0.5 | Ensembl ENCODE | 0.4 | +15.4 | 15377 | 2.7 | SPI1 | FAM156A XAGE3 EIF4A2P4 | |
| GH0XI052864 | Enhancer | 0.2 | ENCODE | 0.8 | +2.6 | 2643 | 1.8 | XAGE3 EIF4A2P4 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around XAGE3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for XAGE3 Gene
Genomic Locations for XAGE3 Gene
- chrX:52,862,525-52,868,135
- (GRCh38/hg38)
- Size:
- 5,611 bases
- Orientation:
- Minus strand
- chrX:52,891,557-52,897,119
- (GRCh37/hg19)
Genomic View for XAGE3 Gene
Genes around XAGE3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp11.22 by Ensembl
- Xp11.22 by Entrez Gene
- Xp11.22 by HGNC
XAGE3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for XAGE3 Gene
Proteins for XAGE3 Gene
-
Protein details for XAGE3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8WTP9-XAGE3_HUMAN
- Recommended name:
- X antigen family member 3
- Protein Accession:
- Q8WTP9
- Q5JS82
- Q8WYS9
Protein attributes for XAGE3 Gene
- Size:
- 111 amino acids
- Molecular mass:
- 12302 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for XAGE3 Gene
No Post-translational modifications
Other Protein References for XAGE3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for XAGE3
- Invitrogen Antibodies for XAGE3
- Search GeneTex for Antibodies for XAGE3
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for XAGE3
- Origene Custom Protein Services for XAGE3
- antibodies-online: Search results for 4 available XAGE3 Proteins ranked by validation data
- Compare Top XAGE3 Proteins
-
Quality Products:
- Search GeneTex for Proteins for XAGE3
Assay Products
No data available for DME Specific Peptides for XAGE3 Gene
Domains & Families for XAGE3 Gene
Gene Families for XAGE3 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for XAGE3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8WTP9- Family:
-
- Belongs to the GAGE family.
Function for XAGE3 Gene
Phenotypes From GWAS Catalog for XAGE3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 23275563 |
Phenotypes for XAGE3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for XAGE3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for XAGE3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for XAGE3 gene
- Search ViGene Biosciences for XAGE3
CRISPR Products
-
OriGene CRISPR knockouts for XAGE3
- genomics-online: gRNA clones - Search results for available XAGE3 gene related products
- Applied Biological Materials CRISPR for XAGE3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for XAGE3
- GenScript: Design CRISPR guide RNA sequences for XAGE3
miRNA Products
- Search ViGene Biosciences for XAGE3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for XAGE3
- Browse OriGene Inhibitory RNA Products For XAGE3
- genomics-online: shRNA clones - Search results for available XAGE3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for XAGE3 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for XAGE3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for XAGE3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available XAGE3 gene related products
- orf clones - Search results for available XAGE3 gene related products
- Applied Biological Materials Clones for XAGE3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for XAGE3
-
ViGene Biosciences adenoviral particle packaged cDNA for XAGE3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for XAGE3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for XAGE3 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for XAGE3 Gene
Localization for XAGE3 Gene
| Compartment | Confidence |
|---|---|
| mitochondrion | 3 |
| nucleus | 2 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for XAGE3 Gene
Pathways & Interactions for XAGE3 Gene
No Data Available
Interacting Proteins for XAGE3 Gene
Selected Interacting proteins:
ENSP00000303061
Q8WTP9-XAGE3_HUMAN
for XAGE3 Gene via
STRING
UniProtKB
IID
No data available for Pathways by source and SIGNOR curated interactions for XAGE3 Gene
Transcripts for XAGE3 Gene
mRNA/cDNA for XAGE3 Gene
- (5) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (24) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for XAGE3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for XAGE3
- genomics-online: gRNA clones - Search results for available XAGE3 gene related products
- Applied Biological Materials CRISPR for XAGE3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for XAGE3
- GenScript: Design CRISPR guide RNA sequences for XAGE3
miRNA Products
- Search ViGene Biosciences for XAGE3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for XAGE3
- Browse OriGene Inhibitory RNA Products For XAGE3
- genomics-online: shRNA clones - Search results for available XAGE3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for XAGE3 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for XAGE3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for XAGE3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available XAGE3 gene related products
- orf clones - Search results for available XAGE3 gene related products
- Applied Biological Materials Clones for XAGE3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for XAGE3 Gene
mRNA differential expression in normal tissues according to GTEx for XAGE3 Gene
This gene is overexpressed in Testis (x25.5), Breast - Mammary Tissue (x7.3), Liver (x6.2), and Adipose - Subcutaneous (x5.5).
NURSA nuclear receptor signaling pathways regulating expression of XAGE3 Gene:
XAGE3SOURCE GeneReport for Unigene cluster for XAGE3 Gene:
Hs.43879Primer Products
-
OriGene qPCR primer pairs for XAGE3
-
OriGene qPCR primer pairs and template standards for XAGE3
- genomics-online: primer clones - Search results for available XAGE3 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for XAGE3 Gene
Orthologs for XAGE3 Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | XAGE3 33 34 |
|
- Species where no ortholog for XAGE3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for XAGE3 Gene
(37) SIMAP similar genes for XAGE3 Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for XAGE3 Gene
Variants for XAGE3 Gene
| SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1007957187 | -- | 52,862,461(-) | C/A | downstream_transcript_variant | |
| rs1014774726 | -- | 52,862,864(-) | T/C | intron_variant | |
| rs1019438059 | -- | 52,862,063(-) | G/A | downstream_transcript_variant | |
| rs1019892743 | -- | 52,862,485(-) | C/A | downstream_transcript_variant | |
| rs1023014799 | -- | 52,862,867(-) | T/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2740170 | CNV | deletion | 23290073 |
| esv2740175 | CNV | deletion | 23290073 |
| esv3576877 | CNV | gain | 25503493 |
| nsv435891 | CNV | deletion | 17901297 |
Residual Variation Intolerance Score:
50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.09;
2.04% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for XAGE3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- XAGE3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XAGE3 Gene
Disorders for XAGE3 Gene
Additional Disease Information for XAGE3
No disorders were found for XAGE3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XAGE3 Gene
Publications for XAGE3 Gene
- The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
- The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PMID: 11992404) Zendman AJ … Van Muijen GN (International journal of cancer 2002) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
Products for XAGE3 Gene
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- Custom Assay Services
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- OriGene qPCR primer pairs and template standards for XAGE3
- OriGene qPCR primer pairs for XAGE3
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping of latest version cDNA ORF clones for XAGE3 in any vector
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- CloneReady with Over 120,000 Genes
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- Sino Biological Transfection Reagent
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- Novus Biologicals Antibodies for XAGE3
- Novus Biologicals lysates and proteins for XAGE3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies at Cloud-Clone Corp.
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
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- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for XAGE3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for XAGE3
- VectorBuilder custom plasmid, inducible vectors for XAGE3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for XAGE3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available XAGE3 related products ranked by validation data
- antibodies-online: Search results for available XAGE3 related products ranked by validation data
- antibodies-online: Search results for 4 available XAGE3 Proteins ranked by validation data
- Compare Top XAGE3 Proteins
- Quality Products:
- Search GeneTex for Antibodies for XAGE3
- Search GeneTex for Proteins for XAGE3
- ViGene Biosciences adenoviral particle packaged cDNA for XAGE3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for XAGE3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for XAGE3 gene
- Search ViGene Biosciences for XAGE3
- Horizon Cell Lines for XAGE3
- genomics-online: cdna clones - Search results for available XAGE3 gene related products
- orf clones - Search results for available XAGE3 gene related products
- genomics-online: gRNA clones - Search results for available XAGE3 gene related products
- genomics-online: primer clones - Search results for available XAGE3 gene related products
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Sources for XAGE3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew