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Aliases & Descriptions for XAGE3
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases CT12.3 3 CT12.3a 1 , 2 GAGED4 2 , 3 MGC71925 2 OTTHUMP00000023319 2 OTTHUMP00000023320 2 PLAC6 2 , 3 , 5 XAGE-3 1 , 2 pp9012 1 , 2
Descriptions Cancer/testis antigen 12.3 3 G antigen, family D, 4 2 Placenta-specific gene 6 protein 3 Protein XAGE-3 3 X antigen family, member 3 2 XAGE-3 protein 2 cancer/testis antigen family 12, member 3a 2 placenta-specific 6 2 placenta-specific 6; G antigen, family D, 4 1
Search outside databases for aliases for XAGE3 genePrevious GC identifer: GC0XM052775
Summaries for XAGE3 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for XAGE3 : This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes areexpressed in a variety of tumors and in some fetal and reproductive tissues. This gene isexpressed in placenta and fetal liver/spleen, and may function in inhibiting cancer cell growth.The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins.Because of the expression pattern and the sequence similarity, this protein also belongs to afamily of CT (cancer-testis) antigens. Alternative splicing of this gene generates 2 transcriptvariants differing in the 5' UTR. [provided by RefSeq] UniProtKB/Swiss-Prot: GAGD4_HUMAN, Q8WTP9 Function : Unknown
Genomic Location for XAGE3
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: Xp11.22-p11.21 Ensembl cytogenetic band: Xp11.22 HGNC cytogenetic band: Xp11.22 XAGE3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XM052908:
(about GC identifiers )
Start:
52,908,282 bp from pter
End:
52,913,844 bp from pter
Size:
5,563 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000023.9 NT_011630.14 Proteins for XAGE3
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: GAGD4_HUMAN, Q8WTP9 (See
protein sequence )Recommended Name: G antigen family D member 4 Size : 111 amino acids; 12302 Da
Secondary accessions : Q5JS82 Q8WYS9
REFSEQ proteins (2 alternative transcripts):
NP_570132.1 NP_573440.1 ENSEMBL proteins: ENSP00000303061 ENSP00000364640 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells Antibodies for XAGE3: Assays for XAGE3:
Protein
Domains/ Families for XAGE3(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q8WTP9 ProtoNet protein and cluster: Q8WTP9
1 Blocks protein family : IPB008625 GAGE UniProtKB/Swiss-Prot: GAGD4_HUMAN, Q8WTP9 Similarity : Belongs to the GAGE family
Gene Function for XAGE3
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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siRNAs from
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_133179 Applied Biosystems Silencer ® siRNAs for XAGE3 Sigma-Aldrich siRNA for XAGE3 Sigma-Aldrich shRNA for XAGE3 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_130776                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_130776                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_130776  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_133179 UniProtKB/Swiss-Prot: GAGD4_HUMAN, Q8WTP9 Function : Unknown
Pathways & Interactions for XAGE3
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Drugs & Compounds for XAGE3 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for XAGE3
Transcripts for XAGE3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
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shRNA from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_133179 Sigma-Aldrich siRNA for XAGE3 Sigma-Aldrich shRNA for XAGE3 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_130776 NM_133179
REFSEQ mRNAs for XAGE3 gene (2 alternative transcripts): NM_130776.1 NM_133179.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_130776 NM_133179
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_130776                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_130776                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_130776  
Additional cDNA sequence: AF318372.1 AJ318881.1 BC062680.1
3 DOTS entries : DT.101970658 DT.97825141 DT.410605
24 AceView cDNA sequences :AJ318881 N32547 NM_130776 N41436 NM_133179 AI189067 AF318372 BC062680 BG354572 N41892 C18417 D59091 BX283272 CF993800 AI742551 T84951 N41723 N40147 BG436468 CB992682 CB994958 CB961487 BG436305 BG435916
highest scoring ESTs for XAGE3 :N40147 AF318372 BG354572 BG436305 BG436468 D59091 AI189067 AI742551 AJ318881 BC062680
Unigene Cluster for XAGE3: X antigen family, member 3 Hs.43879 [show with all ESTs ] Unigene Representative Sequence: CF993800 GeneLoc Exon Structure 2 Ensembl transcripts including schematic representations : ENST00000346279
ENST00000375491
Expression for XAGE3
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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XAGE3 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for XAGE3 1 / 2 / 3
4 probe-sets matching XAGE3 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.43879
Orthologs for XAGE3
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for XAGE3 gene from 1 species
Organism
Gene
Locus
Description
Human Similarity
NCBI accessions
chimpanzee (Pan troglodytes)
XAGE31
--
X antigen family, member 3
99.1(n) 99.1(a)
741714 XM_001144042.1 XP_001144042.1
About this table Species with no ortholog for XAGE3 ENSEMBL Gene Tree for XAGE3 Paralogs for XAGE3 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for XAGE3 gene GAGE2D 2 GAGE10 2 GAGE12H 2 ENSG00000169164 2 XAGE5 2 XAGE2B 2 GAGE12C 2 GAGE12E 2 GAGE2E 2 GAGE1 2 GAGE2C 2 GAGE12F 2 GAGE13 2 PAGE1 2 XAGE2 2 GAGE12G 2 GAGE2B 2 GAGE2A 2 GAGE12J 2 Pseudogenes 1 related pseudogene
SNPs/Variants for XAGE3 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for XAGE3 (up to first 250kb)
Disorders & Mutations for XAGE3
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 300740
Medical News for XAGE3 (Possibly Related Articles in
Doctor's Guide )
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Publications for XAGE3 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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6 PubMed articles for XAGE3 gene :
Search for XAGE3
(in PubMed ,
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Genome Databases showing XAGE3
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing XAGE3
(According to HUGE )
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Specialized Databases showing XAGE3 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for XAGE3 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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