Aliases for XAGE3 Gene
Aliases for XAGE3 Gene
External Ids for XAGE3 Gene
- HGNC: 14618
- Entrez Gene: 170626
- Ensembl: ENSG00000171402
- OMIM: 300740
- UniProtKB: Q8WTP9
Previous HGNC Symbols for XAGE3 Gene
- PLAC6
- GAGED4
Previous GeneCards Identifiers for XAGE3 Gene
- GC0XM052775
Summaries for XAGE3 Gene
-
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is expressed in placenta and fetal liver/spleen, and may function in inhibiting cancer cell growth. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene generates 2 transcript variants differing in the 5' UTR. [provided by RefSeq, Jul 2008]
GeneCards Summary for XAGE3 Gene
XAGE3 (X Antigen Family Member 3) is a Protein Coding gene. An important paralog of this gene is XAGE5.
No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XAGE3 Gene
Genomics for XAGE3 Gene
Regulatory Elements for XAGE3 Gene
Enhancers for XAGE3 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around XAGE3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for XAGE3 Gene
- Chromosome:
- X
- Start:
- 52,862,525 bp from pter
- End:
- 52,868,135 bp from pter
- Size:
- 5,611 bases
- Orientation:
- Minus strand
Genomic View for XAGE3 Gene
Genes around XAGE3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp11.22 by Ensembl
- Xp11.22 by Entrez Gene
- Xp11.22 by HGNC
XAGE3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for XAGE3 Gene
Proteins for XAGE3 Gene
-
Protein details for XAGE3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8WTP9-XAGE3_HUMAN
- Recommended name:
- X antigen family member 3
- Protein Accession:
- Q8WTP9
- Q5JS82
- Q8WYS9
Protein attributes for XAGE3 Gene
- Size:
- 111 amino acids
- Molecular mass:
- 12302 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for XAGE3 Gene
Other Protein References for XAGE3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for XAGE3
- Search GeneTex for Antibodies for XAGE3
-
Santa Cruz Biotechnology (SCBT) Antibodies for XAGE3
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for XAGE3
- Origene Custom Protein Services for XAGE3
- antibodies-online Proteins for XAGE3: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for XAGE3
Assay Products
No data available for DME Specific Peptides for XAGE3 Gene
Domains & Families for XAGE3 Gene
Suggested Antigen Peptide Sequences for XAGE3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8WTP9- Family:
-
- Belongs to the GAGE family.
No data available for Gene Families for XAGE3 Gene
Function for XAGE3 Gene
Phenotypes for XAGE3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for XAGE3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for XAGE3 gene
- Search ViGene Biosciences for XAGE3
CRISPR Products
-
OriGene CRISPR knockouts for XAGE3
-
Santa Cruz Biotechnology (SCBT) CRISPR for XAGE3
- GenScript: Design CRISPR guide RNA sequences for XAGE3
miRNA Products
- Search ViGene Biosciences for XAGE3
Inhibitory RNA Products
- Origene siRNA, shRNA, and RNAi products in human, mouse, rat for XAGE3
- Browse OriGene Inhibitory RNA Products For XAGE3
-
ViGene Biosciences ready-to-package AAV shRNAs for XAGE3 gene
Clone Products
- OriGene clones in human for XAGE3
- OriGene ORF clones in human for XAGE3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: cDNA clones in your preferred vector
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for XAGE3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for XAGE3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for XAGE3 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for XAGE3 Gene
Localization for XAGE3 Gene
| Compartment | Confidence |
|---|---|
| mitochondrion | 3 |
| nucleus | 2 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for XAGE3 Gene
More details on SuperPathways for XAGE3Transcripts for XAGE3 Gene
mRNA/cDNA for XAGE3 Gene
- (5) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (24) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for XAGE3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for XAGE3
-
Santa Cruz Biotechnology (SCBT) CRISPR for XAGE3
- GenScript: Design CRISPR guide RNA sequences for XAGE3
miRNA Products
- Search ViGene Biosciences for XAGE3
Inhibitory RNA Products
- Origene siRNA, shRNA, and RNAi products in human, mouse, rat for XAGE3
- Browse OriGene Inhibitory RNA Products For XAGE3
-
ViGene Biosciences ready-to-package AAV shRNAs for XAGE3 gene
Clone Products
- OriGene clones in human for XAGE3
- OriGene ORF clones in human for XAGE3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: cDNA clones in your preferred vector
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for XAGE3 Gene
mRNA differential expression in normal tissues according to GTEx for XAGE3 Gene
This gene is overexpressed in Testis (x25.5), Breast - Mammary Tissue (x7.3), Liver (x6.2), and Adipose - Subcutaneous (x5.5).
SOURCE GeneReport for Unigene cluster for XAGE3 Gene Hs.43879
Primer Products
-
OriGene qPCR primer pairs for XAGE3
-
OriGene qPCR primer pairs and template standards for XAGE3
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for XAGE3 Gene
Orthologs for XAGE3 Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | XAGE3 35 |
|
||
| XAGE3 36 |
|
OneToOne |
- Species with no ortholog for XAGE3:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for XAGE3 Gene
Paralogs for XAGE3 Gene
(37) SIMAP similar genes for XAGE3 Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for XAGE3 Gene
Variants for XAGE3 Gene
| SNP ID | Clin | Chr 0X pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs2491154 | -- | 52,868,564(-) | GACAT(C/T)ATGAC | upstream-variant-2KB | |
| rs2491155 | -- | 52,868,547(-) | CTGTG(C/T)TGCTG | upstream-variant-2KB | |
| rs2806851 | -- | 52,869,722(+) | CCTCT(A/G)AATGA | upstream-variant-2KB | |
| rs2807031 | -- | 52,867,918(-) | AGCAT(A/G)GCCCG | intron-variant, upstream-variant-2KB, utr-variant-5-prime | |
| rs4143221 | -- | 52,866,535(-) | AGGAG(A/C)ccggt | reference, missense |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2740170 | CNV | Deletion | 23290073 |
| nsv435891 | CNV | Deletion | 17901297 |
| esv2740175 | CNV | Deletion | 23290073 |
Residual Variation Intolerance Score:
50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.09;
2.04% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for XAGE3 Gene
- HapMap Linkage Disequilibrium report
- XAGE3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XAGE3 Gene
Disorders for XAGE3 Gene
Relevant External Links for XAGE3
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- XAGE3
No disorders were found for XAGE3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XAGE3 Gene
Publications for XAGE3 Gene
- The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 67
- A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer. (PMID: 25217961) Al Olama A.A. … Haiman C.A. (Nat. Genet. 2014) 3
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
- Development and application of a DNA microarray-based yeast two-hybrid system. (PMID: 23275563) Suter B. … Wanker E.E. (Nucleic Acids Res. 2013) 3
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
Products for XAGE3 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
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- Browse Immunoprecipitation Assays
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for XAGE3
- Origene Custom Protein Services for XAGE3
- Origene siRNA, shRNA, and RNAi products in human, mouse, rat for XAGE3
- Browse OriGene Inhibitory RNA Products For XAGE3
- OriGene qPCR primer pairs for XAGE3
- OriGene qPCR primer pairs and template standards for XAGE3
- OriGene CRISPR knockouts for XAGE3
- OriGene clones in human for XAGE3
- OriGene ORF clones in human for XAGE3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for XAGE3
- GenScript Custom Assay Services for XAGE3
- GenScript Custom overexpressing Cell Line Services for XAGE3
- GenScript: Design CRISPR guide RNA sequences for XAGE3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for XAGE3
- Novus Biologicals Antibodies for XAGE3
- Novus Biologicals proteins and lysates for XAGE3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ViGene Biosciences adenoviral particle packaged cDNA for XAGE3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for XAGE3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for XAGE3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for XAGE3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for XAGE3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for XAGE3 gene
- Search ViGene Biosciences for XAGE3
- Search ViGene Biosciences for XAGE3
- Santa Cruz Biotechnology (SCBT) Antibodies for XAGE3
- Search Santa Cruz Biotechnology (SCBT) for XAGE3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for XAGE3
Sources for XAGE3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon