Aliases for XAGE3 Gene
Aliases for XAGE3 Gene
External Ids for XAGE3 Gene
- HGNC: 14618
- Entrez Gene: 170626
- Ensembl: ENSG00000171402
- OMIM: 300740
- UniProtKB: Q8WTP9
Previous HGNC Symbols for XAGE3 Gene
- PLAC6
- GAGED4
Previous GeneCards Identifiers for XAGE3 Gene
- GC0XM052775
Summaries for XAGE3 Gene
-
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is expressed in placenta and fetal liver/spleen, and may function in inhibiting cancer cell growth. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene generates 2 transcript variants differing in the 5' UTR. [provided by RefSeq, Jul 2008]
GeneCards Summary for XAGE3 Gene
XAGE3 (X Antigen Family Member 3) is a Protein Coding gene. An important paralog of this gene is XAGE5.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XAGE3 Gene
Genomics for XAGE3 Gene
Regulatory Elements for XAGE3 Gene
Enhancers for XAGE3 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH0XG052864 | 0.4 | ENCODE | 0.7 | +2.6 | 2643 | 1.8 | HNF4A | XAGE3 EIF4A2P4 |
| GH0XG052851 | 0.7 | Ensembl ENCODE | 0.4 | +15.4 | 15378 | 2.7 | FOS SPI1 | FAM156A EIF4A2P4 XAGE3 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around XAGE3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for XAGE3 Gene
- Chromosome:
- X
- Start:
- 52,862,525 bp from pter
- End:
- 52,868,135 bp from pter
- Size:
- 5,611 bases
- Orientation:
- Minus strand
Genomic View for XAGE3 Gene
Genes around XAGE3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xp11.22 by Ensembl
- Xp11.22 by Entrez Gene
- Xp11.22 by HGNC
XAGE3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for XAGE3 Gene
Proteins for XAGE3 Gene
-
Protein details for XAGE3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8WTP9-XAGE3_HUMAN
- Recommended name:
- X antigen family member 3
- Protein Accession:
- Q8WTP9
- Q5JS82
- Q8WYS9
Protein attributes for XAGE3 Gene
- Size:
- 111 amino acids
- Molecular mass:
- 12302 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for XAGE3 Gene
Other Protein References for XAGE3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for XAGE3
-
Abcam antibodies for XAGE3
- Invitrogen Antibodies for XAGE3
- Search GeneTex for Antibodies for XAGE3
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for XAGE3
- Origene Custom Protein Services for XAGE3
- antibodies-online Proteins for XAGE3: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for XAGE3
No data available for DME Specific Peptides for XAGE3 Gene
Domains & Families for XAGE3 Gene
Suggested Antigen Peptide Sequences for XAGE3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8WTP9- Family:
-
- Belongs to the GAGE family.
No data available for Gene Families for XAGE3 Gene
Function for XAGE3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 23275563 |
Phenotypes for XAGE3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for XAGE3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for XAGE3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for XAGE3 gene
- Search ViGene Biosciences for XAGE3
CRISPR Products
-
OriGene CRISPR knockouts for XAGE3
-
Santa Cruz Biotechnology (SCBT) CRISPR for XAGE3
- GenScript: Design CRISPR guide RNA sequences for XAGE3
miRNA Products
- Search ViGene Biosciences for XAGE3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for XAGE3
- Browse OriGene Inhibitory RNA Products For XAGE3
-
ViGene Biosciences ready-to-package AAV shRNAs for XAGE3 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for XAGE3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for XAGE3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for XAGE3
-
ViGene Biosciences adenoviral particle packaged cDNA for XAGE3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for XAGE3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for XAGE3 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for XAGE3 Gene
Localization for XAGE3 Gene
| Compartment | Confidence |
|---|---|
| mitochondrion | 3 |
| nucleus | 2 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for XAGE3 Gene
Pathways & Interactions for XAGE3 Gene
No Data Available
Interacting Proteins for XAGE3 Gene
Selected Interacting proteins:
ENSP00000303061
Q8WTP9-XAGE3_HUMAN
for XAGE3 Gene via
STRING
UniProtKB
IID
No data available for Pathways by source and SIGNOR curated interactions for XAGE3 Gene
Transcripts for XAGE3 Gene
mRNA/cDNA for XAGE3 Gene
- (5) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (24) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for XAGE3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for XAGE3
-
Santa Cruz Biotechnology (SCBT) CRISPR for XAGE3
- GenScript: Design CRISPR guide RNA sequences for XAGE3
miRNA Products
- Search ViGene Biosciences for XAGE3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for XAGE3
- Browse OriGene Inhibitory RNA Products For XAGE3
-
ViGene Biosciences ready-to-package AAV shRNAs for XAGE3 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for XAGE3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for XAGE3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for XAGE3 Gene
mRNA differential expression in normal tissues according to GTEx for XAGE3 Gene
This gene is overexpressed in Testis (x25.5), Breast - Mammary Tissue (x7.3), Liver (x6.2), and Adipose - Subcutaneous (x5.5).
NURSA nuclear receptor signaling pathways regulating expression of XAGE3 Gene:
XAGE3SOURCE GeneReport for Unigene cluster for XAGE3 Gene:
Hs.43879Primer Products
-
OriGene qPCR primer pairs for XAGE3
-
OriGene qPCR primer pairs and template standards for XAGE3
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for XAGE3 Gene
Orthologs for XAGE3 Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | XAGE3 34 35 |
|
- Species where no ortholog for XAGE3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for XAGE3 Gene
Paralogs for XAGE3 Gene
(37) SIMAP similar genes for XAGE3 Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for XAGE3 Gene
Variants for XAGE3 Gene
| SNP ID | Clin | Chr 0X pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1007957187 | -- | 52,862,461(+) | CCACA(A/C)CTGGC | downstream-variant-500B | |
| rs1014774726 | -- | 52,862,864(+) | TTCTG(C/T)AGTTC | intron-variant | |
| rs1019438059 | -- | 52,862,063(+) | TACAG(A/G)GTAGA | downstream-variant-500B | |
| rs1019892743 | -- | 52,862,485(+) | AGTAC(A/C)AAATA | downstream-variant-500B | |
| rs1023014799 | -- | 52,862,867(+) | TGTAG(C/T)TCAAG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2740170 | CNV | deletion | 23290073 |
| esv2740175 | CNV | deletion | 23290073 |
| esv3576877 | CNV | gain | 25503493 |
| nsv435891 | CNV | deletion | 17901297 |
Residual Variation Intolerance Score:
50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.09;
2.04% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for XAGE3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- XAGE3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XAGE3 Gene
Disorders for XAGE3 Gene
Relevant External Links for XAGE3
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- XAGE3
No disorders were found for XAGE3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for XAGE3 Gene
Publications for XAGE3 Gene
- The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
- The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PMID: 11992404) Zendman A.J.W. … van Muijen G.N.P. (Int. J. Cancer 2002) 3 4 64
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
Products for XAGE3 Gene
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- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Custom Antibody Services
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- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for XAGE3
- Origene Custom Protein Services for XAGE3
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for XAGE3
- Browse OriGene Inhibitory RNA Products For XAGE3
- OriGene qPCR primer pairs and template standards for XAGE3
- OriGene qPCR primer pairs for XAGE3
- OriGene CRISPR knockouts for XAGE3
- OriGene ORF clones in human for XAGE3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for XAGE3 in any vector
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- GenScript Custom overexpressing Cell Line Services for XAGE3
- GenScript: Design CRISPR guide RNA sequences for XAGE3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Gene Mutant Library, Variants up to 10^11
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- Novus Biologicals Antibodies for XAGE3
- Novus Biologicals proteins and lysates for XAGE3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for XAGE3
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Invitrogen Antibodies for XAGE3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Search GeneTex for Antibodies for XAGE3
- Search GeneTex for Proteins for XAGE3
- ViGene Biosciences adenoviral particle packaged cDNA for XAGE3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for XAGE3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for XAGE3 gene
- Search ViGene Biosciences for XAGE3
- Horizon Cell Lines for XAGE3
- Cyagen custom Knockout/knockin (KOKI) mouse models for XAGE3
- VectorBuilder custom plasmid, inducible vectors for XAGE3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for XAGE3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for XAGE3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
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- (94) RefSeq
- (95) BioSystems
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- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
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- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
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- (117) DGIdb
- (118) ClinicalTrials
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- (122) diseasecard
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- (136) ViGene Biosciences
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- (141) ENCODE
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- (147) VectorBuilder
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- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer