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XAGE2 Gene

protein-coding   GIFtS: 43
GCID: GC0XM052397

X Antigen Family, Member 2

(Previous names: G antigen, family D, 3)
(Previous symbol: GAGED3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
X Antigen Family, Member 21 2     XAGE-22 3
GAGED31 2 3 5     Cancer/Testis Antigen Family 121
G Antigen, Family D, 31 2     Member 21
Cancer/Testis Antigen 12.22 3     Cancer/Testis Antigen Family 12, Member 22
G Antigen Family D Member 32 3     X Antigen Family Member 22
CT12.22 3     

External Ids:    HGNC: 41121   Entrez Gene: 95022   Ensembl: ENSG000001857517   OMIM: 3004165   UniProtKB: Q96GT93   

Export aliases for XAGE2 gene to outside databases

Previous GC identifers: GC0XP051946 GC0XP049516


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for XAGE2 Gene:
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a
variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in normal testis,
and in Ewing's sarcoma, rhabdomyosarcoma, a breast cancer and a germ cell tumor. The protein encoded by this gene
shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence
similarity, this protein also belongs to a family of CT (cancer-testis) antigens. (provided by RefSeq, Jul 2008)

GeneCards Summary for XAGE2 Gene:
XAGE2 (X antigen family, member 2) is a protein-coding gene. Diseases associated with XAGE2 include hydrocele, and protein c deficiency. An important paralog of this gene is GAGE2D.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_011630.15  
Regulatory elements:
   Search for regulatory transcription factor binding sites for XAGE2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidXAGE2 promoter sequence
   Search Chromatin IP Primers for XAGE2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat XAGE2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.22   Ensembl cytogenetic band:  Xp11.22   HGNC cytogenetic band: Xp11.22-p11.21

XAGE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
XAGE2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM052397:  view genomic region     (about GC identifiers)

Start:
52,380,351 bp from pter      End:
52,387,096 bp from pter
Size:
6,746 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: XAGE2_HUMAN, Q96GT9 (See protein sequence)
Recommended Name: X antigen family member 2  
Size: 111 amino acids; 12354 Da
Secondary accessions: Q5HYR4

Explore the universe of human proteins at neXtProt for XAGE2: NX_Q96GT9

Explore proteomics data for XAGE2 at MOPED


See XAGE2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_570133.1  
ENSEMBL proteins: 
 ENSP00000333775  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR008625 GAGE

Graphical View of Domain Structure for InterPro Entry Q96GT9

ProtoNet protein and cluster: Q96GT9

1 Blocks protein domain: IPB008625 GAGE

UniProtKB/Swiss-Prot: XAGE2_HUMAN, Q96GT9
Similarity: Belongs to the GAGE family


XAGE2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     2 GenomeRNAi human phenotypes for XAGE2:
 Cell cycle / mitosis defect  Increased G2M DNA content 

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion2
nucleus2
cytosol1
extracellular1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for XAGE2
Interactions:

    Search GeneGlobe Interaction Network for XAGE2

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

Selected Interacting proteins for XAGE2 (Q96GT92, 3 ENSP000003337754) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
InteractantInteraction Details
GeneCardExternal ID(s)
ENSG00000206376Q96KQ72, 3MINT-67727 I2D: score=5 
ENSG00000232045Q96KQ72, 3MINT-67727 I2D: score=5 
ENSG00000236759Q96KQ72, 3MINT-67727 I2D: score=5 
ENSG00000238134Q96KQ72, 3MINT-67727 I2D: score=5 
ENSG00000227333Q96KQ72, 3, ENSP000003973234MINT-67727 I2D: score=5 STRING: ENSP00000397323
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for XAGE2



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for XAGE2 gene: 
NM_130777.1  

Unigene Cluster for XAGE2:

X antigen family, member 2
Hs.522654  [show with all ESTs]
Unigene Representative Sequence: BE900651
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000330906(uc004dql.3)
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Additional mRNA sequence: 

AJ318880.1 BC009232.2 BC066311.1 

2 DOTS entries:

DT.214881  DT.95070869 

Selected AceView cDNA sequences (see all 50):

AI128458 NM_130777 AI186558 N30289 BC066311 AA505794 AJ318880 BX103525 
W93043 AI189715 AW972530 BG623213 AI740470 BE903565 BE281431 AI149003 
BG336384 AA993199 BE734431 AA722699 BE733225 CB995986 AI188535 H95793 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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XAGE2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
XAGE2 Expression
About this image

XAGE2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

XAGE2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.522654
    Custom PCR Arrays for XAGE2
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and chimp.

Orthologs for XAGE2 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia XAGE21 X antigen family, member 2 99.4(n)
98.2(a)
  740979  XM_001143378.3  XP_001143378.1 


ENSEMBL Gene Tree for XAGE2 (if available)
TreeFam Gene Tree for XAGE2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for XAGE2 gene
GAGE2D2  XAGE32  GAGE12H2  GAGE102  GAGE12I2  XAGE52  XAGE2B2  GAGE12C2  
GAGE12E2  GAGE12D2  GAGE2E2  GAGE12  GAGE2C2  GAGE12F2  PAGE12  GAGE132  
GAGE12G2  GAGE2B2  GAGE2A2  GAGE12J2  
Selected SIMAP similar genes for XAGE2 using alignment to 1 protein entry:     XAGE2_HUMAN(see all similar genes):
XAGE3    XAGE5    XAGE-4    PAGE3    GAGE2D    GAGE2E
GAGE8    GAGE13    GAGE2A    GAGE2B    GAGE2C    GAGE5
GAGE6    PAGE2    PAGE2B    GAGE4    GAGE10    GAGE12B

XAGE2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Site Specific Mutation Identification with PCR Assays
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DNA2.0 Custom Variant and Variant Library Synthesis for XAGE2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 300416    OMIM disorders: --

7 diseases for XAGE2:    
About MalaCards
hydrocele    protein c deficiency    germ cell tumors    rhabdomyosarcoma
sarcoma    breast cancer    melanoma

1 disease from the University of Copenhagen DISEASES database for XAGE2:
Hydrocele

XAGE2 for disorders           About GeneDecksing


Export disorders for XAGE2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for XAGE2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with XAGE2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database. (PubMed id 10197611)1, 2, 3 Brinkmann U.... Pastan I. (Cancer Res. 1999)
  2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PubMed id 11992404)1, 2 Zendman A.J.W....van Muijen G.N.P. (Int. J. Cancer 2002)
  5. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (amp 2011)
  6. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  8. Hereditary protein C-deficiency: laboratory values in transmitters and guidelines for the diagnostic procedure. Report on a study of the SSC Subcommittee on Protein C and Protein S. Protein C Transmitter Study Group. (PubMed id 1448781)9 Pabinger I....Bertina R.M. (Thromb. Haemost. 1992)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9502 HGNC: 4112 AceView: GAGED3 Ensembl:ENSG00000185751 euGenes: HUgn9502
ECgene: XAGE2 H-InvDB: XAGE2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for XAGE2 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for XAGE2 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for XAGE2 gene:
Search GeneIP for patents involving XAGE2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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