XAGE2 Gene
protein-coding GIFtS: 44
GCID: GC0XM052397
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X antigen family, member 2(Previous names: G antigen, family D, 3 )
(Previous symbol: GAGED3)
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Aliases
for XAGE2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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| Aliases |
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| X Antigen Family, Member 21 2 | | Cancer/Testis Antigen 12.22 3 | | CT12.21 2 3 | | Protein XAGE-22 3 | | GAGED31 2 3 | | Cancer/Testis Antigen Family 12, Member 22 | | XAGE-21 2 | | G Antigen Family D Member 32 | | G Antigen, Family D, 31 2 | | |
Export aliases for XAGE2 gene to outside databasesPrevious GC identifers: GC0XP051946 GC0XP049516 |
Summaries
for XAGE2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for XAGE2:
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in avariety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in normal testis, and inEwing's sarcoma, rhabdomyosarcoma, a breast cancer and a germ cell tumor. The protein encoded by this gene shares asequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, thisprotein also belongs to a family of CT (cancer-testis) antigens. (provided by RefSeq, Jul 2008)
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Genomic Views
for XAGE2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NT_011638.13
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for XAGE2
Other transcription factors
Search SABiosciences Chromatin IP Primers for XAGE2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XAGE2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.22 Ensembl cytogenetic band: Xp11.22 HGNC cytogenetic band: Xp11.22-p11.21XAGE2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM052397: view genomic region
(about GC identifiers)
Start:
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52,380,351 bp from pter |
End:
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52,387,096 bp from pter |
Size:
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6,746 bases |
Orientation:
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minus strand |
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Proteins
for XAGE2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GAGD3_HUMAN, Q96GT9 (See
protein sequence)Recommended Name: G antigen family D member 3 Size: 111 amino acids; 12354 Da
Secondary accessions: Q5HYR4Explore the universe of human proteins at neXtProt for XAGE2: NX_Q96GT9
XAGE2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_570133.1
ENSEMBL proteins: ENSP00000333775
Human Recombinant Protein Products:
XAGE2 Antibody Products:
Assay Products for XAGE2: |
Protein
Domains /
Families
for XAGE2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
XAGE2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96GT9ProtoNet protein and cluster: Q96GT9 1 Blocks protein family: IPB008625 GAGE
UniProtKB/Swiss-Prot: GAGD3_HUMAN, Q96GT9Similarity: Belongs to the GAGE family |
Function
for XAGE2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XAGE2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XAGE2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: XAGE2 (NM_130777) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XAGE2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XAGE2 |
2 GenomeRNAi human phenotypes for XAGE2:
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Pathways & Interactions
for XAGE2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for XAGE2
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for XAGE2 (Q96GT92, 3 ENSP000003337754) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for XAGE2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for XAGE2
Search CenterWatch for drugs/clinical trials and news about XAGE2 / GAGD3
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Transcripts
for XAGE2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for XAGE2 gene: NM_130777.1 Unigene Cluster for XAGE2: X antigen family, member 2 Hs.522654 [show with all ESTs]Unigene Representative Sequence: BE9006511 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000330906(uc004dql.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XAGE2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XAGE2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: XAGE2 (NM_130777) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XAGE2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XAGE2 |
Additional cDNA sequence: AJ318880.1 BC009232.2 BC066311.1 2 DOTS entries: DT.214881 DT.95070869 24/50 AceView cDNA sequences (see all 50): BX103525 AI189715 AJ318880 AI128458 BC066311 N30289 AA505794 NM_130777 W93043 AI186558 BE903565 BE281431 BG623213 BE734431 H00469 AW972530 AA993199 AI149003 AI740470 H00523 CB995986 BC009232 H95793 AI188535
GeneLoc Exon Structure
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Expression
for XAGE2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| XAGE2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See XAGE2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for XAGE2
SOURCE GeneReport for Unigene cluster: Hs.522654
SABiosciences Custom PCR Arrays for XAGE2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XAGE2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat XAGE2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XAGE2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XAGE2 |
Orthologs
for XAGE2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for XAGE2 (if available)
TreeFam Gene Tree for XAGE2 (if available) |
Paralogs
for XAGE2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for XAGE2 gene
- PAGE22 GAGE2D2 GAGE42 XAGE32 GAGE102 GAGE12H2 GAGE12I2 PAGE32
- XAGE52 XAGE2B2 PAGE52 GAGE12C2 GAGE12E2 GAGE12D2 PAGE2B2 GAGE12
- GAGE2E2 GAGE2C2 GAGE12F2 PAGE12 GAGE132 GAGE12G2 GAGE2A2 GAGE2B2
- PAGE42 GAGE12J2
18/31 SIMAP similar genes for XAGE2 using alignment to 1 protein entry: GAGD3_HUMAN(see all similar genes):XAGE3 XAGE5 XAGE-4 PAGE3 GAGE2D GAGE2E
GAGE8 GAGE13 GAGE2A GAGE2B GAGE2C GAGE5
GAGE6 PAGE2 PAGE2B GAGE4 GAGE10 GAGE12B
XAGE2 for paralogs About GeneDecksing
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Genomic Variants
for XAGE2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for XAGE2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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XAGE2 for disorders About GeneDecksing
OMIM gene information: 300416
OMIM disorders: --
7  diseases for XAGE2: About MalaCardssarcoma germ cell tumor protein c deficiency breast cancer
hydrocele rhabdomyosarcoma melanoma
1 disease from the University of Copenhagen DISEASES database for XAGE2:Hydrocele Export disorders for XAGE2 gene to outside databases
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Publications
for XAGE2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for XAGE2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with XAGE2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database. (PubMed id 10197611)1, 2, 3 Brinkmann U.... Pastan I. (1999)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PubMed id 11992404)1, 2 Zendman A.J.W....van Muijen G.N.P. (2002)
- Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hereditary protein C-deficiency: laboratory values in transmitters and guidelines for the diagnostic procedure. Report on a study of the SSC Subcommittee on Protein C and Protein S. Protein C Transmitter Study G roup. (PubMed id 1448781)9 Pabinger I....Bertina R.M. (1992)
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External Searches for XAGE2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing XAGE2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing XAGE2 gene
(According to HUGE)
About This Section
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Specialized Databases showing XAGE2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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About This Section
| Patent Information for XAGE2 gene:
Search GeneIP for patents involving XAGE2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for XAGE2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for XAGE2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for XAGE2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for XAGE2 | | | OriGene Protein Over-expression Lysate for XAGE2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for XAGE2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for XAGE2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for XAGE2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for XAGE2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for XAGE2 | | OriGene Custom Protein Services for XAGE2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat XAGE2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing XAGE2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XAGE2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat XAGE2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat XAGE2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat XAGE2 |
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| | | | Search Tocris compounds for XAGE2 |
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 | | | XAGE2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for XAGE2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat XAGE2 |
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