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Aliases for XAGE1E Gene

Aliases for XAGE1E Gene

  • X Antigen Family, Member 1E 2 3
  • G Antigen Family D Member 2 3 4
  • Cancer/Testis Antigen 12.1 3 4
  • CT12.1 3 4
  • GAGED2 3 4
  • XAGE-1 3 4
  • XAGE1 3 4
  • Cancer/Testis Antigen Family 12, Member 1c 3
  • Cancer/Testis Antigen Family 12, Member 1d 3
  • Cancer/Testis Antigen Family 12, Member 1e 3
  • Cancer/Testis Associated Protein 3
  • X Antigen Family, Member 1D 3
  • X Antigen Family, Member 1C 3
  • X Antigen Family Member 1 3
  • Protein XAGE-1 3
  • CT12.1C 3
  • CT12.1D 3
  • CT12.1E 3
  • XAGE1C 3
  • XAGE1D 3
  • CTP9 3

External Ids for XAGE1E Gene

Previous GeneCards Identifiers for XAGE1E Gene

  • GC0XU900700
  • GC0XM052559
  • GC0XM052273
  • GC0XP052257
  • GC0XP052259

Summaries for XAGE1E Gene

Entrez Gene Summary for XAGE1E Gene

  • This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signal and shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene, in addition to alternative transcription start sites, results in multiple transcript variants. [provided by RefSeq, Jan 2010]

GeneCards Summary for XAGE1E Gene

XAGE1E (X Antigen Family, Member 1E) is a Protein Coding gene. Diseases associated with XAGE1E include rhabdomyosarcoma. An important paralog of this gene is XAGE1A.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XAGE1E Gene

Genomics for XAGE1E Gene

Regulatory Elements for XAGE1E Gene

Genomic Location for XAGE1E Gene

52,512,077 bp from pter
52,520,803 bp from pter
8,727 bases
Minus strand

Genomic View for XAGE1E Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for XAGE1E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XAGE1E Gene

Proteins for XAGE1E Gene

  • Protein details for XAGE1E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    X antigen family member 1
    Protein Accession:
    Secondary Accessions:
    • A6NJ94
    • Q5JPN8
    • Q5JPP0
    • Q5JPP3
    • Q8WWG5
    • Q8WWG6
    • Q969J6

    Protein attributes for XAGE1E Gene

    81 amino acids
    Molecular mass:
    9078 Da
    Quaternary structure:
    No Data Available
    • According to PubMed:11992404, the transcription of XAGE1A is regulated by methylation of the CpG island in the promoter, and four alternative RNA splicing variants, XAGE-1a, b, c have been identified
    • Sequence=AAG01401.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH09538.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAC82986.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI40888.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40895.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41526.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41531.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41534.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for XAGE1E Gene


neXtProt entry for XAGE1E Gene

Proteomics data for XAGE1E Gene at MOPED

Post-translational modifications for XAGE1E Gene

  • Ubiquitination at Lys12
  • Modification sites at PhosphoSitePlus

Other Protein References for XAGE1E Gene

No data available for DME Specific Peptides for XAGE1E Gene

Domains for XAGE1E Gene

Protein Domains for XAGE1E Gene


Suggested Antigen Peptide Sequences for XAGE1E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9HD64
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with XAGE1E: view

No data available for Gene Families for XAGE1E Gene

Function for XAGE1E Gene

Gene Ontology (GO) - Molecular Function for XAGE1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with XAGE1E: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for XAGE1E Gene

Localization for XAGE1E Gene

Subcellular locations from

Jensen Localization Image for XAGE1E Gene COMPARTMENTS Subcellular localization image for XAGE1E gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for XAGE1E Gene

Pathways for XAGE1E Gene

SuperPathways for XAGE1E Gene

No Data Available

Interacting Proteins for XAGE1E Gene

Gene Ontology (GO) - Biological Process for XAGE1E Gene


No data available for Pathways by source for XAGE1E Gene

Transcripts for XAGE1E Gene

mRNA/cDNA for XAGE1E Gene

(9) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for XAGE1E

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for XAGE1E
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for XAGE1E Gene

No ASD Table

Relevant External Links for XAGE1E Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for XAGE1E Gene

mRNA expression in normal human tissues for XAGE1E Gene

mRNA differential expression in normal tissues according to GTEx for XAGE1E Gene

This gene is overexpressed in Testis (53.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for XAGE1E Gene

mRNA Expression by UniProt/SwissProt for XAGE1E Gene

Tissue specificity: In normal tissues, highly expressed in testis. Expressed also in many different types of cancers: highly expressed in breast cancer, prostate cancer and many types of lung cancers, including squamous cell carcinoma, small cell carcinoma, non-small cell carcinoma, and adenocarcinoma, as well as in Ewings cell lines, in some Ewings sarcoma patient samples, and in one of one alveolar rhabdomyosarcoma patient sample.
genes like me logo Genes that share expressions with XAGE1E: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for XAGE1E Gene

Orthologs for XAGE1E Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for XAGE1E Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 36
  • 53 (a)
Species with no ortholog for XAGE1E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for XAGE1E Gene

Gene Tree for XAGE1E (if available)
Gene Tree for XAGE1E (if available)

Paralogs for XAGE1E Gene

Paralogs for XAGE1E Gene

Selected SIMAP similar genes for XAGE1E Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with XAGE1E: view

Variants for XAGE1E Gene

Sequence variations from dbSNP and Humsavar for XAGE1E Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs200248162 -- 52,511,739(-) TTTTT(A/T)AAAAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for XAGE1E Gene

Variant ID Type Subtype PubMed ID
esv29848 CNV Gain+Loss 19812545
esv1003754 CNV Loss 20482838
esv991419 CNV Loss 20482838
esv994563 CNV Loss 20482838
esv28509 CNV Gain+Loss 19812545
nsv7445 OTHER Inversion 18451855
esv1004613 CNV Loss 20482838

Relevant External Links for XAGE1E Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XAGE1E Gene

Disorders for XAGE1E Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for XAGE1E Gene including...

Search for XAGE1E Gene in MalaCards »

(1) University of Copenhagen DISEASES for XAGE1E Gene

genes like me logo Genes that share disorders with XAGE1E: view

No data available for UniProtKB/Swiss-Prot for XAGE1E Gene

Publications for XAGE1E Gene

  1. Identification of XAGE-1 isoforms: predominant expression of XAGE-1b in testis and tumors. (PMID: 17335148) Sato S. … Nakayama E. (Cancer Immun. 2007) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma. (PMID: 10987281) Liu X.F. … Pastan I. (Cancer Res. 2000) 3 4
  5. The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PMID: 11992404) Zendman A.J.W. … van Muijen G.N.P. (Int. J. Cancer 2002) 3 4

Products for XAGE1E Gene

Sources for XAGE1E Gene

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