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Aliases for XAGE1E Gene

Aliases for XAGE1E Gene

  • X Antigen Family Member 1E 2 3
  • G Antigen Family D Member 2 3 4
  • X Antigen Family, Member 1E 2 3
  • Cancer/Testis Antigen 12.1 3 4
  • GAGED2 3 4
  • CT12.1 3 4
  • XAGE-1 3 4
  • XAGE1 3 4
  • Cancer/Testis Antigen Family 12, Member 1c 3
  • Cancer/Testis Antigen Family 12, Member 1d 3
  • Cancer/Testis Antigen Family 12, Member 1e 3
  • XAGE1A XAGE1B XAGE1C XAGE1D XAGE1E 4
  • Cancer/Testis Associated Protein 3
  • X Antigen Family, Member 1C 3
  • X Antigen Family, Member 1D 3
  • X Antigen Family Member 1B 5
  • Protein XAGE-1 3
  • CT12.1C 3
  • CT12.1D 3
  • CT12.1E 3
  • XAGE1C 3
  • XAGE1D 3
  • XAGE1B 5
  • CTP9 3

External Ids for XAGE1E Gene

Previous GeneCards Identifiers for XAGE1E Gene

  • GC0XU900700
  • GC0XM052559
  • GC0XM052273
  • GC0XP052257
  • GC0XP052259

Summaries for XAGE1E Gene

Entrez Gene Summary for XAGE1E Gene

  • This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signal and shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene, in addition to alternative transcription start sites, results in multiple transcript variants. [provided by RefSeq, Jan 2010]

GeneCards Summary for XAGE1E Gene

XAGE1E (X Antigen Family Member 1E) is a Protein Coding gene. Diseases associated with XAGE1E include ewing sarcoma. An important paralog of this gene is XAGE1A.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XAGE1E Gene

Genomics for XAGE1E Gene

Regulatory Elements for XAGE1E Gene

Genomic Location for XAGE1E Gene

Chromosome:
X
Start:
52,512,077 bp from pter
End:
52,520,803 bp from pter
Size:
8,727 bases
Orientation:
Minus strand

Genomic View for XAGE1E Gene

Genes around XAGE1E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XAGE1E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XAGE1E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XAGE1E Gene

Proteins for XAGE1E Gene

  • Protein details for XAGE1E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HD64-XAGE1_HUMAN
    Recommended name:
    X antigen family member 1
    Protein Accession:
    Q9HD64
    Secondary Accessions:
    • A6NJ94
    • Q5JPN8
    • Q5JPP0
    • Q5JPP3
    • Q8WWG5
    • Q8WWG6
    • Q969J6

    Protein attributes for XAGE1E Gene

    Size:
    81 amino acids
    Molecular mass:
    9078 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • According to PubMed:11992404, the transcription of XAGE1A is regulated by methylation of the CpG island in the promoter, and four alternative RNA splicing variants, XAGE-1a, b, c have been identified.
    SequenceCaution:
    • Sequence=AAG01401.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH09538.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAC82986.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI40888.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40895.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41526.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41531.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41534.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for XAGE1E Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for XAGE1E Gene

Proteomics data for XAGE1E Gene at MOPED

Post-translational modifications for XAGE1E Gene

  • Ubiquitination at Lys 12
  • Modification sites at PhosphoSitePlus

Other Protein References for XAGE1E Gene

No data available for DME Specific Peptides for XAGE1E Gene

Domains & Families for XAGE1E Gene

Protein Domains for XAGE1E Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for XAGE1E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HD64

UniProtKB/Swiss-Prot:

XAGE1_HUMAN :
  • Belongs to the GAGE family.
Family:
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with XAGE1E: view

No data available for Gene Families for XAGE1E Gene

Function for XAGE1E Gene

genes like me logo Genes that share phenotypes with XAGE1E: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for XAGE1E Gene

Localization for XAGE1E Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for XAGE1E Gene

Pathways & Interactions for XAGE1E Gene

SuperPathways for XAGE1E Gene

No Data Available

Interacting Proteins for XAGE1E Gene

Gene Ontology (GO) - Biological Process for XAGE1E Gene

None

No data available for Pathways by source and SIGNOR curated interactions for XAGE1E Gene

Drugs & Compounds for XAGE1E Gene

No Compound Related Data Available

Transcripts for XAGE1E Gene

mRNA/cDNA for XAGE1E Gene

(9) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for XAGE1E Gene

No ASD Table

Relevant External Links for XAGE1E Gene

GeneLoc Exon Structure for
XAGE1E
ECgene alternative splicing isoforms for
XAGE1E

Expression for XAGE1E Gene

mRNA expression in normal human tissues for XAGE1E Gene

mRNA differential expression in normal tissues according to GTEx for XAGE1E Gene

This gene is overexpressed in Testis (x53.0).

Protein differential expression in normal tissues from HIPED for XAGE1E Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (32.2), Colon muscle (27.6), and Testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for XAGE1E Gene



mRNA Expression by UniProt/SwissProt for XAGE1E Gene

Q9HD64-XAGE1_HUMAN
Tissue specificity: In normal tissues, highly expressed in testis. Expressed also in many different types of cancers: highly expressed in breast cancer, prostate cancer and many types of lung cancers, including squamous cell carcinoma, small cell carcinoma, non-small cell carcinoma, and adenocarcinoma, as well as in Ewings cell lines, in some Ewings sarcoma patient samples, and in one of one alveolar rhabdomyosarcoma patient sample.
genes like me logo Genes that share expression patterns with XAGE1E: view

Protein tissue co-expression partners for XAGE1E Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for XAGE1E Gene

Orthologs for XAGE1E Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for XAGE1E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 53 (a)
OneToMany
Species with no ortholog for XAGE1E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for XAGE1E Gene

ENSEMBL:
Gene Tree for XAGE1E (if available)
TreeFam:
Gene Tree for XAGE1E (if available)

Paralogs for XAGE1E Gene

Paralogs for XAGE1E Gene

(1) SIMAP similar genes for XAGE1E Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with XAGE1E: view

Variants for XAGE1E Gene

Sequence variations from dbSNP and Humsavar for XAGE1E Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs112243563 -- 52,513,686(-) ACCTC(C/T)TGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for XAGE1E Gene

Variant ID Type Subtype PubMed ID
esv29848 CNV Gain+Loss 19812545
esv1003754 CNV Loss 20482838
esv991419 CNV Loss 20482838
esv994563 CNV Loss 20482838
esv28509 CNV Gain+Loss 19812545
nsv7445 OTHER Inversion 18451855
esv1004613 CNV Loss 20482838

Relevant External Links for XAGE1E Gene

HapMap Linkage Disequilibrium report
XAGE1E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for XAGE1E Gene

Disorders for XAGE1E Gene

MalaCards: The human disease database

(1) MalaCards diseases for XAGE1E Gene - From: GeneCards

Disorder Aliases PubMed IDs
ewing sarcoma
  • neuroepithelioma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for XAGE1E

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
XAGE1E
genes like me logo Genes that share disorders with XAGE1E: view

No data available for UniProtKB/Swiss-Prot and Genatlas for XAGE1E Gene

Publications for XAGE1E Gene

  1. Identification of XAGE-1 isoforms: predominant expression of XAGE-1b in testis and tumors. (PMID: 17335148) Sato S. … Nakayama E. (Cancer Immun. 2007) 3 4 67
  2. Prolongation of overall survival in advanced lung adenocarcinoma patients with the XAGE1 (GAGED2a) antibody. (PMID: 25124687) Ohue Y. … Nakayama E. (Clin. Cancer Res. 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Heteroclitic serological response in esophageal and prostate cancer patients after NY-ESO-1 protein vaccination. (PMID: 21413013) Kawada J. … Nakayama E. (Int. J. Cancer 2012) 3
  5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3

Products for XAGE1E Gene

Sources for XAGE1E Gene

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