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Aliases for XAGE1D Gene

Aliases for XAGE1D Gene

  • X Antigen Family, Member 1D 2
  • XAGE1A XAGE1B XAGE1C XAGE1D XAGE1E 4
  • Cancer/Testis Antigen Family 12 2
  • G Antigen Family D Member 2 4
  • Cancer/Testis Antigen 12.1 4
  • Member 1d 2
  • CT12.1 4
  • GAGED2 4
  • XAGE-1 4
  • XAGE1 4

External Ids for XAGE1D Gene

Previous GeneCards Identifiers for XAGE1D Gene

  • GC0XU900701
  • GC0XM052545

Summaries for XAGE1D Gene

GeneCards Summary for XAGE1D Gene

XAGE1D (X Antigen Family, Member 1D) is a Protein Coding gene. Diseases associated with XAGE1D include melanoma metastasis and testicular cancer.

Gene Wiki entry for XAGE1D Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XAGE1D Gene

Genomics for XAGE1D Gene

Genomic Location for XAGE1D Gene

Orientation:
Unknown strand

Genomic View for XAGE1D Gene

Cytogenetic band:

No data available for Regulatory Elements and RefSeq DNA sequence for XAGE1D Gene

Proteins for XAGE1D Gene

  • Protein details for XAGE1D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HD64-XAGE1_HUMAN
    Recommended name:
    X antigen family member 1
    Protein Accession:
    Q9HD64
    Secondary Accessions:
    • A6NJ94
    • Q5JPN8
    • Q5JPP0
    • Q5JPP3
    • Q8WWG5
    • Q8WWG6
    • Q969J6

    Protein attributes for XAGE1D Gene

    Size:
    81 amino acids
    Molecular mass:
    9078 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • According to PubMed:11992404, the transcription of XAGE1A is regulated by methylation of the CpG island in the promoter, and four alternative RNA splicing variants, XAGE-1a, b, c have been identified
    SequenceCaution:
    • Sequence=AAG01401.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH09538.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAC82986.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI40888.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40895.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41526.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41531.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41534.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for XAGE1D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for XAGE1D Gene

Proteomics data for XAGE1D Gene at MOPED

Post-translational modifications for XAGE1D Gene

  • Ubiquitination at Lys12
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for XAGE1D Gene

Domains for XAGE1D Gene

Protein Domains for XAGE1D Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9HD64

UniProtKB/Swiss-Prot:

XAGE1_HUMAN :
  • Q9HD64
Family:
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with XAGE1D: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for XAGE1D Gene

Function for XAGE1D Gene

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for XAGE1D

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for XAGE1D Gene

Localization for XAGE1D Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for XAGE1D Gene COMPARTMENTS Subcellular localization image for XAGE1D gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for XAGE1D Gene

Pathways for XAGE1D Gene

SuperPathways for XAGE1D Gene

No Data Available

Interacting Proteins for XAGE1D Gene

Gene Ontology (GO) - Biological Process for XAGE1D Gene

None

No data available for Pathways by source for XAGE1D Gene

Transcripts for XAGE1D Gene

Unigene Clusters for XAGE1D Gene

X antigen family, member 1D:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for XAGE1D

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for XAGE1D Gene

No ASD Table

Relevant External Links for XAGE1D Gene

ECgene alternative splicing isoforms for
XAGE1D

Expression for XAGE1D Gene

mRNA expression in normal human tissues for XAGE1D Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for XAGE1D Gene

SOURCE GeneReport for Unigene cluster for XAGE1D Gene Hs.112208

mRNA Expression by UniProt/SwissProt for XAGE1D Gene

Q9HD64-XAGE1_HUMAN
Tissue specificity: In normal tissues, highly expressed in testis. Expressed also in many different types of cancers: highly expressed in breast cancer, prostate cancer and many types of lung cancers, including squamous cell carcinoma, small cell carcinoma, non-small cell carcinoma, and adenocarcinoma, as well as in Ewings cell lines, in some Ewings sarcoma patient samples, and in one of one alveolar rhabdomyosarcoma patient sample.
genes like me logo Genes that share expressions with XAGE1D: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for XAGE1D Gene

Orthologs for XAGE1D Gene

No data available for Orthologs and Evolution for XAGE1D Gene

Paralogs for XAGE1D Gene

Selected SIMAP similar genes for XAGE1D Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with XAGE1D: view

No data available for Paralogs for XAGE1D Gene

Variants for XAGE1D Gene

Structural Variations from Database of Genomic Variants (DGV) for XAGE1D Gene

Variant ID Type Subtype PubMed ID
esv29848 CNV Gain+Loss 19812545
esv1003754 CNV Loss 20482838
esv991419 CNV Loss 20482838
esv994563 CNV Loss 20482838
esv28509 CNV Gain+Loss 19812545
nsv7445 OTHER Inversion 18451855
esv1004613 CNV Loss 20482838

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for XAGE1D Gene

Disorders for XAGE1D Gene

MalaCards: The human disease database

MalaCards: The human disease database. (5) Diseases for XAGE1D Gene including...

Search for XAGE1D Gene in MalaCards »

(1) University of Copenhagen DISEASES for XAGE1D Gene

(11) Novoseek inferred disease relationships for XAGE1D Gene

Disease -log(P) Hits PubMed IDs
adenocarcinoma lung 68.8 3
ewings sarcoma 68.7 3
testicular cancer 68.5 3
small cell lung cancer 49.6 1
cancer lung 45.6 2
genes like me logo Genes that share disorders with XAGE1D: view

No data available for UniProtKB/Swiss-Prot for XAGE1D Gene

Publications for XAGE1D Gene

  1. Characterization of overlapping XAGE-1 transcripts encoding a cancer testis antigen expressed in lung, breast, and other types of cancers. (PMID: 12479262) Egland K.A. … Pastan I. (Mol. Cancer Ther. 2002) 4 23
  2. Identification of XAGE-1 isoforms: predominant expression of XAGE-1b in testis and tumors. (PMID: 17335148) Sato S. … Nakayama E. (Cancer Immun. 2007) 4 23
  3. mRNA expression of the XAGE-1 gene in human acute leukemia. (PMID: 20178013) Ji Y. … Gu L. (Int. J. Hematol. 2010) 23
  4. XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma. (PMID: 10987281) Liu X.F. … Pastan I. (Cancer Res. 2000) 4
  5. The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PMID: 11992404) Zendman A.J.W. … van Muijen G.N.P. (Int. J. Cancer 2002) 4

Products for XAGE1D Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate XAGE1D
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for XAGE1D
    • Block miRNA regulation of XAGE1D using miScript Target Protectors

    Sources for XAGE1D Gene

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