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Aliases for XAGE1C Gene

Aliases for XAGE1C Gene

  • X Antigen Family, Member 1C 2
  • XAGE1A XAGE1B XAGE1C XAGE1D XAGE1E 4
  • Cancer/Testis Antigen Family 12 2
  • G Antigen Family D Member 2 4
  • Cancer/Testis Antigen 12.1 4
  • Member 1c 2
  • CT12.1 4
  • GAGED2 4
  • XAGE-1 4
  • XAGE1 4

External Ids for XAGE1C Gene

Summaries for XAGE1C Gene

GeneCards Summary for XAGE1C Gene

XAGE1C (X Antigen Family, Member 1C) is a Protein Coding gene. Diseases associated with XAGE1C include rhabdomyosarcoma.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XAGE1C Gene

Genomics for XAGE1C Gene

Genomic Location for XAGE1C Gene

Orientation:
Unknown strand

Genomic View for XAGE1C Gene

Cytogenetic band:

Regulatory Elements for XAGE1C Gene

No data available for RefSeq DNA sequence for XAGE1C Gene

Proteins for XAGE1C Gene

  • Protein details for XAGE1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HD64-XAGE1_HUMAN
    Recommended name:
    X antigen family member 1
    Protein Accession:
    Q9HD64
    Secondary Accessions:
    • A6NJ94
    • Q5JPN8
    • Q5JPP0
    • Q5JPP3
    • Q8WWG5
    • Q8WWG6
    • Q969J6

    Protein attributes for XAGE1C Gene

    Size:
    81 amino acids
    Molecular mass:
    9078 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • According to PubMed:11992404, the transcription of XAGE1A is regulated by methylation of the CpG island in the promoter, and four alternative RNA splicing variants, XAGE-1a, b, c have been identified
    SequenceCaution:
    • Sequence=AAG01401.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH09538.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAC82986.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI40888.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40895.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41526.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41531.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41534.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for XAGE1C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for XAGE1C Gene

Proteomics data for XAGE1C Gene at MOPED

Post-translational modifications for XAGE1C Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys12

No data available for DME Specific Peptides for XAGE1C Gene

Domains for XAGE1C Gene

Protein Domains for XAGE1C Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9HD64

UniProtKB/Swiss-Prot:

XAGE1_HUMAN
Family:
  • Belongs to the GAGE family.:
    • Q9HD64
genes like me logo Genes that share domains with XAGE1C: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for XAGE1C Gene

Function for XAGE1C Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for XAGE1C Gene

Localization for XAGE1C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for XAGE1C Gene COMPARTMENTS Subcellular localization image for XAGE1C gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for XAGE1C Gene

Pathways for XAGE1C Gene

SuperPathways for XAGE1C Gene

No Data Available

Interacting Proteins for XAGE1C Gene

Gene Ontology (GO) - Biological Process for XAGE1C Gene

None

No data available for Pathways by source for XAGE1C Gene

Transcripts for XAGE1C Gene

Alternative Splicing Database (ASD) splice patterns (SP) for XAGE1C Gene

No ASD Table

Relevant External Links for XAGE1C Gene

ECgene alternative splicing isoforms for
XAGE1C

No data available for mRNA/cDNA for XAGE1C Gene

Expression for XAGE1C Gene

mRNA expression in normal human tissues for XAGE1C Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for XAGE1C Gene

mRNA Expression by UniProt/SwissProt for XAGE1C Gene

Q9HD64-XAGE1_HUMAN
Tissue specificity: In normal tissues, highly expressed in testis. Expressed also in many different types of cancers: highly expressed in breast cancer, prostate cancer and many types of lung cancers, including squamous cell carcinoma, small cell carcinoma, non-small cell carcinoma, and adenocarcinoma, as well as in Ewings cell lines, in some Ewings sarcoma patient samples, and in one of one alveolar rhabdomyosarcoma patient sample.
genes like me logo Genes that share expressions with XAGE1C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for XAGE1C Gene

Orthologs for XAGE1C Gene

No data available for Orthologs and Evolution for XAGE1C Gene

Paralogs for XAGE1C Gene

Selected SIMAP similar genes for XAGE1C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with XAGE1C: view

No data available for Paralogs for XAGE1C Gene

Variants for XAGE1C Gene

Structural Variations from Database of Genomic Variants (DGV) for XAGE1C Gene

Variant ID Type Subtype PubMed ID
esv29848 CNV Gain+Loss 19812545
esv1003754 CNV Loss 20482838
esv991419 CNV Loss 20482838
esv994563 CNV Loss 20482838
esv28509 CNV Gain+Loss 19812545
nsv7445 OTHER Inversion 18451855
esv1004613 CNV Loss 20482838

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for XAGE1C Gene

Disorders for XAGE1C Gene

(1) MalaCards Diseases for XAGE1C Gene

Search for XAGE1C Gene in MalaCards »

(1) University of Copenhagen DISEASES for XAGE1C Gene

genes like me logo Genes that share disorders with XAGE1C: view

No data available for UniProtKB/Swiss-Prot for XAGE1C Gene

Publications for XAGE1C Gene

  1. XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma. (PMID: 10987281) Liu X.F. … Pastan I. (Cancer Res. 2000) 4
  2. The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PMID: 11992404) Zendman A.J.W. … van Muijen G.N.P. (Int. J. Cancer 2002) 4
  3. Characterization of overlapping XAGE-1 transcripts encoding a cancer testis antigen expressed in lung, breast, and other types of cancers. (PMID: 12479262) Egland K.A. … Pastan I. (Mol. Cancer Ther. 2002) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 4

Products for XAGE1C Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate XAGE1C
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for XAGE1C
    • Block miRNA regulation of XAGE1C using miScript Target Protectors

    Sources for XAGE1C Gene

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