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Aliases for XAGE1B Gene

Aliases for XAGE1B Gene

  • X Antigen Family, Member 1B 2 3
  • G Antigen Family D Member 2 3 4
  • Cancer/Testis Antigen 12.1 3 4
  • CT12.1 3 4
  • GAGED2 3 4
  • XAGE-1 3 4
  • XAGE1 3 4
  • Cancer/Testis Antigen Family 12, Member 1a 3
  • Cancer/Testis Antigen Family 12, Member 1b 3
  • XAGE1A XAGE1B XAGE1C XAGE1D XAGE1E 4
  • Cancer/Testis Associated Protein 3
  • Cancer/Testis Antigen Family 12 2
  • X Antigen Family, Member 1A 3
  • X Antigen Family Member 1 3
  • Protein XAGE-1 3
  • Member 1b 2
  • CT12.1A 3
  • CT12.1B 3
  • XAGE1A 3
  • CTP9 3

External Ids for XAGE1B Gene

Previous GeneCards Identifiers for XAGE1B Gene

  • GC0XU900702
  • GC0XM052272
  • GC0XP052530
  • GC0XM052561
  • GC0XP052239

Summaries for XAGE1B Gene

Entrez Gene Summary for XAGE1B Gene

  • This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signal and shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene, in addition to alternative transcription start sites, results in multiple transcript variants. [provided by RefSeq, Jan 2010]

GeneCards Summary for XAGE1B Gene

XAGE1B (X Antigen Family, Member 1B) is a Protein Coding gene. Diseases associated with XAGE1B include rhabdomyosarcoma. An important paralog of this gene is XAGE1A.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XAGE1B Gene

Genomics for XAGE1B Gene

Regulatory Elements for XAGE1B Gene

Genomic Location for XAGE1B Gene

Start:
52,495,668 bp from pter
End:
52,500,812 bp from pter
Size:
5,145 bases
Orientation:
Plus strand

Genomic View for XAGE1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for XAGE1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for XAGE1B Gene

Proteins for XAGE1B Gene

  • Protein details for XAGE1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HD64-XAGE1_HUMAN
    Recommended name:
    X antigen family member 1
    Protein Accession:
    Q9HD64
    Secondary Accessions:
    • A6NJ94
    • Q5JPN8
    • Q5JPP0
    • Q5JPP3
    • Q8WWG5
    • Q8WWG6
    • Q969J6

    Protein attributes for XAGE1B Gene

    Size:
    81 amino acids
    Molecular mass:
    9078 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • According to PubMed:11992404, the transcription of XAGE1A is regulated by methylation of the CpG island in the promoter, and four alternative RNA splicing variants, XAGE-1a, b, c have been identified
    SequenceCaution:
    • Sequence=AAG01401.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH09538.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAC82986.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI40888.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40895.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41526.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41531.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41534.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for XAGE1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for XAGE1B Gene

Proteomics data for XAGE1B Gene at MOPED

Post-translational modifications for XAGE1B Gene

  • Ubiquitination at Lys12
  • Modification sites at PhosphoSitePlus

Other Protein References for XAGE1B Gene

No data available for DME Specific Peptides for XAGE1B Gene

Domains for XAGE1B Gene

Protein Domains for XAGE1B Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9HD64

UniProtKB/Swiss-Prot:

XAGE1_HUMAN :
  • Q9HD64
Family:
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with XAGE1B: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for XAGE1B Gene

Function for XAGE1B Gene

Gene Ontology (GO) - Molecular Function for XAGE1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with XAGE1B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for XAGE1B Gene

Localization for XAGE1B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for XAGE1B Gene COMPARTMENTS Subcellular localization image for XAGE1B gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for XAGE1B Gene

Pathways for XAGE1B Gene

SuperPathways for XAGE1B Gene

No Data Available

Interacting Proteins for XAGE1B Gene

Gene Ontology (GO) - Biological Process for XAGE1B Gene

None

No data available for Pathways by source for XAGE1B Gene

Transcripts for XAGE1B Gene

mRNA/cDNA for XAGE1B Gene

(6) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for XAGE1B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for XAGE1B
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for XAGE1B Gene

No ASD Table

Relevant External Links for XAGE1B Gene

GeneLoc Exon Structure for
XAGE1B
ECgene alternative splicing isoforms for
XAGE1B

Expression for XAGE1B Gene

mRNA expression in normal human tissues for XAGE1B Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for XAGE1B Gene

mRNA Expression by UniProt/SwissProt for XAGE1B Gene

Q9HD64-XAGE1_HUMAN
Tissue specificity: In normal tissues, highly expressed in testis. Expressed also in many different types of cancers: highly expressed in breast cancer, prostate cancer and many types of lung cancers, including squamous cell carcinoma, small cell carcinoma, non-small cell carcinoma, and adenocarcinoma, as well as in Ewings cell lines, in some Ewings sarcoma patient samples, and in one of one alveolar rhabdomyosarcoma patient sample.
genes like me logo Genes that share expressions with XAGE1B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for XAGE1B Gene

Orthologs for XAGE1B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for XAGE1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 53 (a)
OneToMany
Species with no ortholog for XAGE1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for XAGE1B Gene

ENSEMBL:
Gene Tree for XAGE1B (if available)
TreeFam:
Gene Tree for XAGE1B (if available)

Paralogs for XAGE1B Gene

Paralogs for XAGE1B Gene

Selected SIMAP similar genes for XAGE1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with XAGE1B: view

Variants for XAGE1B Gene

Sequence variations from dbSNP and Humsavar for XAGE1B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs112090233 -- 52,500,563(-) GCTTA(C/T)ATTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for XAGE1B Gene

Variant ID Type Subtype PubMed ID
esv29848 CNV Gain+Loss 19812545
esv1003754 CNV Loss 20482838
esv991419 CNV Loss 20482838
esv994563 CNV Loss 20482838
esv28509 CNV Gain+Loss 19812545
nsv7445 OTHER Inversion 18451855
esv1004613 CNV Loss 20482838

Relevant External Links for XAGE1B Gene

HapMap Linkage Disequilibrium report
XAGE1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XAGE1B Gene

Disorders for XAGE1B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for XAGE1B Gene including...

Search for XAGE1B Gene in MalaCards »

(1) University of Copenhagen DISEASES for XAGE1B Gene

genes like me logo Genes that share disorders with XAGE1B: view

No data available for UniProtKB/Swiss-Prot for XAGE1B Gene

Publications for XAGE1B Gene

  1. Identification of XAGE-1 isoforms: predominant expression of XAGE-1b in testis and tumors. (PMID: 17335148) Sato S. … Nakayama E. (Cancer Immun. 2007) 3 4
  2. The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma. (PMID: 11992404) Zendman A.J.W. … van Muijen G.N.P. (Int. J. Cancer 2002) 3 4
  3. Characterization of overlapping XAGE-1 transcripts encoding a cancer testis antigen expressed in lung, breast, and other types of cancers. (PMID: 12479262) Egland K.A. … Pastan I. (Mol. Cancer Ther. 2002) 3 4
  4. XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma. (PMID: 10987281) Liu X.F. … Pastan I. (Cancer Res. 2000) 3 4
  5. Characterization of XAGE-1b, a short major transcript of cancer/testis-associated gene XAGE-1, induced in melanoma metastasis. (PMID: 11774264) Zendman A.J. … van Muijen G.N. (Int. J. Cancer 2002) 3

Products for XAGE1B Gene

Sources for XAGE1B Gene

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