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Aliases for XAGE1A Gene

Aliases for XAGE1A Gene

  • X Antigen Family Member 1A 2 5
  • Cancer/Testis Antigen Family 12 2
  • X Antigen Family, Member 1A 2
  • G Antigen Family D Member 2 4
  • X Antigen Family, Member 1 2
  • Cancer/Testis Antigen 12.1 4
  • G Antigen, Family D, 2 2
  • Member 1a 2
  • GAGED2 4
  • CT12.1 4
  • XAGE-1 4
  • XAGE1 4

External Ids for XAGE1A Gene

Previous HGNC Symbols for XAGE1A Gene

  • GAGED2
  • XAGE1

Previous GeneCards Identifiers for XAGE1A Gene

  • GC0XM052546
  • GC0XP052532
  • GC0XP052258
  • GC0XP052238
  • GC0XM052255

Summaries for XAGE1A Gene

GeneCards Summary for XAGE1A Gene

XAGE1A (X Antigen Family Member 1A) is a Protein Coding gene. An important paralog of this gene is XAGE1B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XAGE1A Gene

Genomics for XAGE1A Gene

Regulatory Elements for XAGE1A Gene

Genomic Location for XAGE1A Gene

52,495,676 bp from pter
52,500,812 bp from pter
5,137 bases
Plus strand

Genomic View for XAGE1A Gene

Genes around XAGE1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XAGE1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XAGE1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for RefSeq DNA sequence for XAGE1A Gene

Proteins for XAGE1A Gene

  • Protein details for XAGE1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    X antigen family member 1
    Protein Accession:
    Secondary Accessions:
    • A6NJ94
    • Q5JPN8
    • Q5JPP0
    • Q5JPP3
    • Q8WWG5
    • Q8WWG6
    • Q969J6

    Protein attributes for XAGE1A Gene

    81 amino acids
    Molecular mass:
    9078 Da
    Quaternary structure:
    No Data Available
    • According to PubMed:11992404, the transcription of XAGE1A is regulated by methylation of the CpG island in the promoter, and four alternative RNA splicing variants, XAGE-1a, b, c have been identified.
    • Sequence=AAG01401.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH09538.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAC82986.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI40888.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40895.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41526.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41531.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41534.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for XAGE1A Gene


neXtProt entry for XAGE1A Gene

Proteomics data for XAGE1A Gene at MOPED

Post-translational modifications for XAGE1A Gene

  • Ubiquitination at Lys 12
  • Modification sites at PhosphoSitePlus

Other Protein References for XAGE1A Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for XAGE1A Gene

Domains & Families for XAGE1A Gene

Protein Domains for XAGE1A Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GAGE family.
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with XAGE1A: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for XAGE1A Gene

Function for XAGE1A Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for XAGE1A Gene

Localization for XAGE1A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for XAGE1A Gene

Pathways & Interactions for XAGE1A Gene

SuperPathways for XAGE1A Gene

No Data Available

Interacting Proteins for XAGE1A Gene

Gene Ontology (GO) - Biological Process for XAGE1A Gene


No data available for Pathways by source and SIGNOR curated interactions for XAGE1A Gene

Drugs & Compounds for XAGE1A Gene

No Compound Related Data Available

Transcripts for XAGE1A Gene

mRNA/cDNA for XAGE1A Gene

(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for XAGE1A Gene

No ASD Table

Relevant External Links for XAGE1A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for XAGE1A Gene

mRNA expression in normal human tissues for XAGE1A Gene

Protein differential expression in normal tissues from HIPED for XAGE1A Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (32.2), Colon muscle (27.6), and Testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for XAGE1A Gene

mRNA Expression by UniProt/SwissProt for XAGE1A Gene

Tissue specificity: In normal tissues, highly expressed in testis. Expressed also in many different types of cancers: highly expressed in breast cancer, prostate cancer and many types of lung cancers, including squamous cell carcinoma, small cell carcinoma, non-small cell carcinoma, and adenocarcinoma, as well as in Ewings cell lines, in some Ewings sarcoma patient samples, and in one of one alveolar rhabdomyosarcoma patient sample.
genes like me logo Genes that share expression patterns with XAGE1A: view

Protein tissue co-expression partners for XAGE1A Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for XAGE1A Gene

Orthologs for XAGE1A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for XAGE1A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 36
  • 53 (a)
Species with no ortholog for XAGE1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for XAGE1A Gene

Gene Tree for XAGE1A (if available)
Gene Tree for XAGE1A (if available)

Paralogs for XAGE1A Gene

Paralogs for XAGE1A Gene

(1) SIMAP similar genes for XAGE1A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with XAGE1A: view

Variants for XAGE1A Gene

Structural Variations from Database of Genomic Variants (DGV) for XAGE1A Gene

Variant ID Type Subtype PubMed ID
esv29848 CNV Gain+Loss 19812545
esv1003754 CNV Loss 20482838
esv991419 CNV Loss 20482838
esv994563 CNV Loss 20482838
esv28509 CNV Gain+Loss 19812545
nsv7445 OTHER Inversion 18451855
esv1004613 CNV Loss 20482838

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Variation tolerance and Relevant External Links for XAGE1A Gene

Disorders for XAGE1A Gene

No disorders were found for XAGE1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for XAGE1A Gene

Publications for XAGE1A Gene

  1. Identification of XAGE-1 isoforms: predominant expression of XAGE-1b in testis and tumors. (PMID: 17335148) Sato S. … Nakayama E. (Cancer Immun. 2007) 4 67
  2. Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database. (PMID: 10197611) Brinkmann U. … Pastan I. (Cancer Res. 1999) 2

Products for XAGE1A Gene

Sources for XAGE1A Gene