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Aliases for XAGE1A Gene

Aliases for XAGE1A Gene

  • X Antigen Family Member 1A 2 5
  • Cancer/Testis Antigen Family 12, Member 1a 2
  • XAGE1A XAGE1B XAGE1C XAGE1D XAGE1E 4
  • X Antigen Family, Member 1A 2
  • G Antigen Family D Member 2 4
  • X Antigen Family, Member 1 2
  • Cancer/Testis Antigen 12.1 4
  • G Antigen, Family D, 2 2
  • GAGED2 4
  • CT12.1 4
  • XAGE-1 4
  • XAGE1 4

External Ids for XAGE1A Gene

Previous HGNC Symbols for XAGE1A Gene

  • GAGED2
  • XAGE1

Previous GeneCards Identifiers for XAGE1A Gene

  • GC0XM052546
  • GC0XP052532
  • GC0XP052258
  • GC0XP052238
  • GC0XM052255

Summaries for XAGE1A Gene

GeneCards Summary for XAGE1A Gene

XAGE1A (X Antigen Family Member 1A) is a Protein Coding gene. An important paralog of this gene is XAGE1B.

Additional gene information for XAGE1A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XAGE1A Gene

Genomics for XAGE1A Gene

Regulatory Elements for XAGE1A Gene

Enhancers for XAGE1A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH052933 2 FANTOM5 Ensembl ENCODE dbSUPER 14.6 +439.3 439263 2 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 YY1 ZNF143 ZNF207 DEK SSXP5 SSX7 RPSAP62 XAGE1A XAGE1B SPANXN5 IQSEC2 TSPYL2 FAM156A KDM5C
GH0XH053223 1.1 ENCODE 14.6 +729.1 729059 2 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 GPR173 FAM156B TSPYL2 ACTG1P10 KANTR RPSAP62 SSXP5 SSX7 XAGE1A XAGE1B
GH0XH053420 1.1 ENCODE 14.6 +926.7 926655 2 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 ZNF548 TSPYL2 GPR173 SMC1A RPSAP62 XAGE1A XAGE1B SSX7 SSXP5 RPL7AP71 ACTG1P10
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around XAGE1A on UCSC Golden Path with GeneCards custom track

Genomic Location for XAGE1A Gene

Chromosome:
X
Start:
52,495,676 bp from pter
End:
52,500,812 bp from pter
Size:
5,137 bases
Orientation:
Plus strand

Genomic View for XAGE1A Gene

Genes around XAGE1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
XAGE1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for XAGE1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for RefSeq DNA sequence for XAGE1A Gene

Proteins for XAGE1A Gene

  • Protein details for XAGE1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HD64-XAGE1_HUMAN
    Recommended name:
    X antigen family member 1
    Protein Accession:
    Q9HD64
    Secondary Accessions:
    • A6NJ94
    • Q5JPN8
    • Q5JPP0
    • Q5JPP3
    • Q8WWG5
    • Q8WWG6
    • Q969J6

    Protein attributes for XAGE1A Gene

    Size:
    81 amino acids
    Molecular mass:
    9078 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • According to PubMed:11992404, the transcription of XAGE1A is regulated by methylation of the CpG island in the promoter, and four alternative RNA splicing variants, XAGE-1a, b, c have been identified.
    SequenceCaution:
    • Sequence=AAG01401.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH09538.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAC82986.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI40888.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40895.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41526.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41531.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41534.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for XAGE1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for XAGE1A Gene

Post-translational modifications for XAGE1A Gene

  • Ubiquitination at Lys12
  • Modification sites at PhosphoSitePlus

Other Protein References for XAGE1A Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for XAGE1A Gene

Domains & Families for XAGE1A Gene

Gene Families for XAGE1A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for XAGE1A Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9HD64

UniProtKB/Swiss-Prot:

XAGE1_HUMAN :
  • Belongs to the GAGE family.
Family:
  • Belongs to the GAGE family.
genes like me logo Genes that share domains with XAGE1A: view

No data available for Suggested Antigen Peptide Sequences for XAGE1A Gene

Function for XAGE1A Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for XAGE1A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for XAGE1A Gene

Localization for XAGE1A Gene

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for XAGE1A Gene

Pathways & Interactions for XAGE1A Gene

SuperPathways for XAGE1A Gene

No Data Available

Gene Ontology (GO) - Biological Process for XAGE1A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for XAGE1A Gene

Drugs & Compounds for XAGE1A Gene

No Compound Related Data Available

Transcripts for XAGE1A Gene

mRNA/cDNA for XAGE1A Gene

(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for XAGE1A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for XAGE1A Gene

No ASD Table

Relevant External Links for XAGE1A Gene

GeneLoc Exon Structure for
XAGE1A
ECgene alternative splicing isoforms for
XAGE1A

Expression for XAGE1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for XAGE1A Gene

Protein differential expression in normal tissues from HIPED for XAGE1A Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (32.2), Colon muscle (27.6), and Testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for XAGE1A Gene



Protein tissue co-expression partners for XAGE1A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of XAGE1A Gene:

XAGE1A

mRNA Expression by UniProt/SwissProt for XAGE1A Gene:

Q9HD64-XAGE1_HUMAN
Tissue specificity: In normal tissues, highly expressed in testis. Expressed also in many different types of cancers: highly expressed in breast cancer, prostate cancer and many types of lung cancers, including squamous cell carcinoma, small cell carcinoma, non-small cell carcinoma, and adenocarcinoma, as well as in Ewings cell lines, in some Ewings sarcoma patient samples, and in one of one alveolar rhabdomyosarcoma patient sample.
genes like me logo Genes that share expression patterns with XAGE1A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for XAGE1A Gene

Orthologs for XAGE1A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for XAGE1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 53 (a)
OneToMany
Species where no ortholog for XAGE1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for XAGE1A Gene

ENSEMBL:
Gene Tree for XAGE1A (if available)
TreeFam:
Gene Tree for XAGE1A (if available)

Paralogs for XAGE1A Gene

Paralogs for XAGE1A Gene

(1) SIMAP similar genes for XAGE1A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with XAGE1A: view

Variants for XAGE1A Gene

Relevant External Links for XAGE1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
XAGE1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for XAGE1A Gene

Disorders for XAGE1A Gene

No disorders were found for XAGE1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for XAGE1A Gene

Publications for XAGE1A Gene

  1. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 60
  3. Identification of XAGE-1 isoforms: predominant expression of XAGE-1b in testis and tumors. (PMID: 17335148) Sato S … Nakayama E (Cancer immunity 2007) 4 60
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60

Products for XAGE1A Gene

Sources for XAGE1A Gene

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