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XAGE1A Gene

protein-coding   GIFtS: 25

GC0XP052258
X antigen family, member 1A
(Previous names: G antigen, family D, 2, X antigen family, member 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: GAGED2, XAGE1)
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Aliases &
Descriptions
for XAGE1A

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
CT12.1 3
CT12.1a 1, 2
GAGED2 2, 3
XAGE-1 1, 2
XAGE1 2
Descriptions
Cancer/testis antigen 12.1 3
G antigen, family D, 2 1, 2
Protein XAGE-1 3
X antigen family, member 1 1, 2
X antigen family, member 1A 2
cancer/testis antigen family 12, member 1a 2
xage-1 p16 2
External Ids
HGNC: 41111
Entrez Gene: 6532192
UniProtKB: Q9HD643
Ensembl: ENSG000002043827
Search outside databases for aliases for XAGE1A gene

Previous GC identifers: GC0XM052546 GC0XP052532

Summaries
for XAGE1A

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for XAGE1A:
XAGE1A is 1 of 5 copies of the XAGE1 gene (see XAGE1D; MIM 300289) (Chen et al., 2006 [PubMed
16382448]).[supplied by OMIM]

UniProtKB/Swiss-Prot: GAGD2_HUMAN, Q9HD64
Function: Unknown

Genomic Location
for XAGE1A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.22   Ensembl cytogenetic band:  Xp11.22   HGNC cytogenetic band: Xp11.22-p11.21

XAGE1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP052258:     (about GC identifiers)

Start:
 52,255,543 bp from pter
End:
 52,260,679 bp from pter
Size:
 5,137 bases
Orientation:
 plus strand

Proteins
for XAGE1A

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: GAGD2_HUMAN, Q9HD64 (See protein sequence)
Recommended Name: G antigen family D member 2  
Size: 160 amino acids; 17751 Da
Secondary accessions: A6NJ94 Q5JPP0 Q5JPP3 Q8WWG5 Q8WWG6 Q969J6
Alternative splicing: 3 isoforms:  Q9HD64-3   Q9HD64-2   Q9HD64-4   

REFSEQ proteins (3 alternative transcripts): 
NP_001091060.1  NP_001091061.1  NP_001091062.1  


ENSEMBL proteins: 
ENSP00000364763 ENSP00000364766 ENSP00000382704 ENSP00000364762 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (XAGE1)
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for XAGE1A: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Antibodies from Abcam (XAGE1), each with their AbpromiseSM
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for XAGE1A

Assays for XAGE1A: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for XAGE1A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro domain/family:
 IPR008625 GAGE


   GeneDecks  XAGE1A for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q9HD64

ProtoNet protein and cluster: Q9HD64

1 Blocks protein family: IPB008625 GAGE

UniProtKB/Swiss-Prot: GAGD2_HUMAN, Q9HD64
Similarity: Belongs to the GAGE family

Gene Function
for XAGE1A

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
                Browse Origene for 29mer shRNA kit in GFP-retroviral vector

              Applied Biosystems Silencer® siRNAs for XAGE1A

              Sigma-Aldrich siRNA for XAGE1A  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001097591
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001097591
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001097591 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001097591

UniProtKB/Swiss-Prot: GAGD2_HUMAN, Q9HD64
Function: Unknown

Pathways & Interactions
for XAGE1A

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

Drugs & Compounds
for XAGE1A

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for XAGE1A

Transcripts
for XAGE1A

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
                Browse Origene for 29mer shRNA kit in GFP-retroviral vector

              Sigma-Aldrich siRNA for XAGE1A  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001097591  NM_001097592  NM_001097593  

REFSEQ mRNAs for XAGE1A gene (3 alternative transcripts): 

NM_001097591.1   NM_001097592.1   NM_001097593.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001097591  NM_001097592  NM_001097593  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001097591
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001097591
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001097591 


GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:
ENST00000375613  ENST00000375616  ENST00000399805  ENST00000375612  

Expression
for XAGE1A

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

XAGE1A expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for XAGE1A

1 / 2

3 probe-sets matching XAGE1A gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

56998_at2 U95-B 5 1.00 0.20 1.00 1.00 -- -- -- -- --

220057_at2 U133-A 5 1.00 0.20 -- -- -- -- -- -- --

220057_at2 U133Plus2 5 1.00 0.20 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

UniProtKB/Swiss-Prot: GAGD2_HUMAN, Q9HD64
Tissue specificity: In normal tissues, highly expressed in testis. Expressed also in many different
types of cancers: highly expressed in breast cancer, prostate cancer and many types of lung
cancers, including squamous cell carcinoma, small cell carcinoma, non-small cell carcinoma, and
adenocarcinoma, as well as in Ewing's cell lines, in some Ewing's sarcoma patient samples, and in
one of one alveolar rhabdomyosarcoma patient sample

Orthologs
for XAGE1A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

 ENSEMBL Gene Tree for XAGE1A

Paralogs
for XAGE1A

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for XAGE1A gene
XAGE1E2  XAGE1B2  XAGE1D2  XAGE1C2  

SNPs/Variants
for XAGE1A

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

  --

Disorders & Mutations
for XAGE1A

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 300742

Medical News
for XAGE1A

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for XAGE1A

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

7 PubMed articles for XAGE1A gene:

Search for XAGE1A

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing XAGE1A

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 653219 HGNC: 4111 Ensembl:ENSG00000204382 euGenes: HUgn653219 ECgene: XAGE1A
H-InvDB: XAGE1A

Other Databases showing XAGE1A

(According to HUGE)
About This Section

   --

Specialized Databases showing XAGE1A

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for XAGE1A

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for XAGE1A

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for XAGE1A:
 TaqMan ® Gene Expression Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for XAGE1A-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for XAGE1A Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Browse shRNAs at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant & Natural Proteins  

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 Recombinant Proteins
(XAGE1)
 Antibodies (XAGE1)
 Search OriGene for XAGE1A
 Search Tocris compounds for XAGE1A




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Search Novus for antibodies for XAGE1A

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