XAF1 Gene
protein-coding GIFtS : 51 GCID: GC17 P006659
XIAP associated factor 1
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Aliasesfor XAF1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases XIAP Associated Factor 1 1 2 BIRC4-Binding Protein2 3 BIRC4BP1 2 3 BIRC4 Binding Protein2 XIAPAF11 2 3 XIAP-Associated Factor 12 HSXIAPAF11 2
Export aliases for XAF1 gene to outside databases Previous GC identifers: GC17P006601 GC17P006554
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Summariesfor XAF1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for XAF1 : This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Feb 2012) UniProtKB/Swiss-Prot: XAF1_HUMAN, Q6GPH4 Function : Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family.Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells Gene Wiki entry for XAF1
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Genomic Viewsfor XAF1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000017.10 NC_018928.1 NT_010718.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the XAF1 gene promoter:COUP-TF1 S8 COUP-TF AML1a COUP LyF-1 Pax-4a HNF-4alpha1 Other transcription factors Search SABiosciences Chromatin IP Primers for XAF1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XAF1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13.2 XAF1 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17P006659: view genomic region
(about GC identifiers )
Start: 6,658,766 bp from pter End:
6,678,966 bp from pter
Size: 20,201 bases Orientation:
plus strand
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Proteinsfor XAF1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: XAF1_HUMAN, Q6GPH4 See
protein sequence )Recommended Name: Size : 301 amino acids; 34626 DaSubunit : Interacts with BIRC4; the interaction is not detected in (PubMed:16432762). Interacts with BIRC1, BIRC2,BIRC3, BIRC7 and BIRC8. Part of an complex consisting of BIRC4, XAF1 and BIRC5; the complex formation requires IFN-beta stimulation
Subcellular location : Cytoplasm. Nucleus. Mitochondrion. Note=Found in the cytoplasm and nucleus of placentalsyncytiotrophoblasts. Translocates to mitochondria upon TNF-alpha treatment
Subcellular location : Isoform 1: NucleusSubcellular location : Isoform 5: NucleusDevelopmental stage : Selectively expressed in third trimester placentaSequence caution : Sequence=AAH32776.1; Type=Erroneous initiation; Sequence=CAA68030.1; Type=Frameshift; Positions=294;Secondary accessions : A2T931 A2T932 A8K2L1 A8K9Y3 D3DTM6 Q6MZE8 Q8N557 Q99982Alternative splicing : 7 isoforms : Q6GPH4-1 Q6GPH4-2 Q6GPH4-3 Q6GPH4-4 Q6GPH4-5 Q6GPH4-6 Q6GPH4-7 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for XAF1: NX_Q6GPH4 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q6GPH4 XAF1 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (2 alternative transcripts): NP_059993.2 NP_954590.1 ENSEMBL proteins: ENSP00000461750 ENSP00000460373 ENSP00000341029 ENSP00000354822 ENSP00000461698 ENSP00000458321 ENSP00000459543 ENSP00000460632 ENSP00000460315 ENSP00000461635 ENSP00000458229 ENSP00000461196 ENSP00000413199 ENSP00000406233 Reactome Protein details: Q6GPH4 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing XAF1 Antibody Products: Assay Products for XAF1:
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Protein
Domains /for XAF1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q6GPH4 ProtoNet protein and cluster: Q6GPH4
UniProtKB/Swiss-Prot: XAF1_HUMAN, Q6GPH4 Similarity : Contains 1 TRAF-type zinc finger
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Functionfor XAF1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: XAF1_HUMAN, Q6GPH4 Function : Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family.Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells Induction : Up-regulated by IFNB1/IFN-beta in cell lines sensitive to the proapoptotic effects of IFNB1 but not inapoptosis-resistant cells. Up-regulated by TNF in trophoblast cells
Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): XAF1 (NM_017523 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XAF1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse rat XAF1
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XAF1
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0008270 zinc ion binding
IEA --
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Pathways & Interactionsfor XAF1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways About this table See pathways by source Super-pathway contained gene-specific pathways 1 Expression of IFN-induced genes 2 Cytokine Signaling in Immune system 3 Immune System
Pathway sources See GeneCards unified pathways Show all pathways 5 About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for XAF1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/44 Interacting proteins for XAF1 (Q6GPH4 3 ENSP00000354822 4 via UniProtKB, MINT, STRING , and/or I2D (see all 44 )About this table Gene Ontology (GO): 4 biological process terms (GO ID links to tree view) : About this table
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Drugs & Compoundsfor XAF1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for XAF1 1 Novoseek chemical compound relationship for XAF1 gene About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
5-aza-2'deoxycytidine
52.1
3
15843754 (1), 14612497 (1)
XAF1
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Transcriptsfor XAF1 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for XAF1 gene (2 alternative transcripts): NM_017523.3 NM_199139.2 Unigene Cluster for XAF1:
XIAP associated factor 1 Hs.441975 [show with all ESTs ] Unigene Representative Sequence: BX648588 18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21 ): ENST00000573760 ENST00000575369 (uc010clr.1 uc002gdm.1 ) ENST00000576341 ENST00000574394 ENST00000346752 ENST00000361842 (uc002gdn.3 uc002gdp.3 uc002gdq.3 uc002gdr.3 )ENST00000576459 ENST00000572546 ENST00000575267 ENST00000572107 ENST00000576724 ENST00000571217 ENST00000575147 ENST00000574907 ENST00000571135 ENST00000574962 ENST00000571673 ENST00000572495 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): XAF1 (NM_017523 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for XAF1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse rat XAF1
Additional cDNA sequence: AK091799.1 AK128092.1 AK290276.1 AK292710.1 AK292848.1 BC032776.1 BC058017.1 BC073156.1 BX648588.1 EF028165.1 EF028166.1 NR_046396.1 NR_046397.1 NR_046398.1 X99699.1
13 DOTS entries : DT.70100215 DT.106672
DT.100783882 DT.40247731 DT.100783878 DT.101983944 DT.100783880 DT.120921051 DT.95300500 DT.86838148 DT.86843622 DT.95096626 DT.95307618 24/153 AceView cDNA sequences (see all 153 ):
AI148361 AI671675 AA911966 CB139521 BM984102 AI671656 BC073156 BF111792 CA398245 AA361525 BU678951 BM460522 BG575167 AA568824 AV649497 BX281713 NM_017523 AA861677 AI352370 AI583096 AI799335 CA406124 AI963638 AI347382 GeneLoc Exon Structure 5/17 Alternative Splicing Database (ASD) splice patterns (SP) for XAF1 (see all 17 ) About this scheme ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · SP1 : - - - - - - - - - - - - - SP2 : - - - - - - - - - - SP3 : - - - - - - - - - - - - SP4 : - - - - - - - - - - - - - - SP5 : - - - - - - - - -
ExUns: 12b ^ 13a · 13b ^ 14a · 14b · 14c · 14d SP1 : SP2 : SP3 : SP4 : SP5 :
ECgene alternative splicing isoforms for XAF1
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Expression for XAF1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section XAF1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TGCCCCTGAA
About this image XAF1 expression in embryonic tissues and stem cells About this table See XAF1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for XAF1 SOURCE GeneReport for Unigene cluster: Hs.441975 UniProtKB/Swiss-Prot: XAF1_HUMAN, Q6GPH4 Tissue specificity : Widely expressed. Expression is frequently down-regulated in cancer cell lines. Isoform 5 is widelyexpressed. Expressed in placenta (at protein level) SABiosciences Custom PCR Arrays for XAF1 Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XAF1
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Orthologsfor XAF1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for XAF1 gene from 4/10 species (see all 10 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves XAF11
XIAP associated factor 1
51.5(n) 39.47(a)
417677 XM_415922.3 XP_415922.3
zebrafish Actinopterygii zgc:1538931
zgc:153893
46.98(n) 31.1(a)
767709 NM_001076647.1 NP_001070115.1
thale cress eudicotyledons AT1G099206
TRAF-type zinc finger-related protein
24(a)
1 → many
1(3224684-3227070)
rice Liliopsida ----
TRAF-type zinc finger domain-containing protein 1,... TRAF-type zinc finger domain-containing protein 1,... 23(a) 22(a)
many ↔ manymany ↔ many
7(27683366-27685534) 3(13742270-13746877)
ENSEMBL Gene Tree for XAF1 (if available)TreeFam Gene Tree for XAF1 (if available)
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Paralogsfor XAF1 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for XAF1 gene TRAFD1 2 1 SIMAP similar gene for XAF1 using alignment to 9 protein entries: XAF1_HUMAN (see all proteins ):TRAFD1 About GeneDecksing
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Genomic Variantsfor XAF1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 17 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for XAF1 (6658766 - 6678966 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for XAF1: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor XAF1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 606717
OMIM disorders : --20/22 (see all 22 ): About MalaCards thymic dysplasia chronic lymphocytic leukemia lymphocytic leukemia renal cell carcinoma colon cancer gastric adenocarcinoma hepatitis b renal carcinoma adenocarcinoma hepatocellular carcinoma gastric cancer carcinoma pancreatic cancer colorectal cancer leukemia melanoma prostate cancer pancreatitis myeloma hepatitis 6 Novoseek disease relationships for XAF1 gene About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
adenocarcinoma gastric
57.1
7
17471152 (3), 18807090 (3)
colon cancer
40.1
4
15843754 (2), 18362468 (1)
cancer
33.1
13
14612497 (3), 11175744 (2), 15843754 (1), 16343440 (1) (see all 7 )
tumors
31.3
15
15610524 (3), 14612497 (2), 15843754 (1), 16353137 (1) (see all 7 )
melanoma
8.16
11
15610524 (5), 12029096 (2)
carcinoma
0
3
17471152 (2), 14612497 (1)
Export disorders for XAF1 gene to outside databases
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Publicationsfor XAF1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for XAF1 gene, integrated from 9 sources (see all 57 ):(articles sorted by number of sources associating them with XAF1) Utopia : connect your pdf to the dynamic
Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis. (PubMed id 12029096) 1 , 2 , 3, 9(2002) Identification of XAF1 as an antagonist of XIAP anti-Caspase activity. (PubMed id 11175744) 1 , 2 , 3, 9(2001) Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complex. (PubMed id 17613533) 1 , 2 , 9(2007) Identification of a novel splice variant of X-linked inhibitor of apoptosis-associated factor 1. (PubMed id 16343440) 1 , 2 , 9(2006) Frequent alteration of XAF1 in human colorectal cancers: implication for tumor cell resistance to apoptotic stresses. (PubMed id 17570219) 1 , 2 (2007) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 (2004) Hypermethylation of XIAP-associated factor 1, a putative tumor suppressor gene from the 17p13.2 locus, in human gastric adenocarcinomas. (PubMed id 14612497) 1 , 9(2003) Switch to full-length of XAF1 mRNA expression in prostate cancer cells by the DNA methylation inhibitor. (PubMed id 16353137) 1 , 9(2006) Disturbed expression of the apoptosis regulators XIAP, XAF1, and Smac/DIABLO in gastric adenocarcinomas. (PubMed id 17471152) 1 , 9(2007) XAF1 expression is significantly reduced in human melanoma. (PubMed id 15610524) 1 , 9(2004)
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Specialized Databases showing XAF1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for XAF1 gene: XAF1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor XAF1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for XAF1 OriGene shRNA RFP for XAF1 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for XAF1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for XAF1 OriGene 3'-UTR Clone for XAF1 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for XAF1 OriGene Custom Protein Services for XAF1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat XAF1 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat XAF1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for XAF1
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse rat XAF1
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Expression by the Database of Embryonic development, Stem cell research, and
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