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XAF1 Gene

protein-coding   GIFtS: 51

GC17P006601
XIAP associated factor 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for XAF1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
BIRC4BP 1, 2, 3
HSXIAPAF1 1, 2
XIAPAF1 1, 2, 3
Descriptions
BIRC4 binding protein 2
BIRC4-binding protein 3
XIAP associated factor 1 2
External Ids
HGNC: 309321
Entrez Gene: 547392
UniProtKB: Q6GPH43
Ensembl: ENSG000001325307
Search outside databases for aliases for XAF1 gene

Summaries
for XAF1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for XAF1:
X-linked inhibitor of apoptosis (XIAP; MIM 300079) is a potent member of the IAP family. All
members of this family possess baculoviral IAP (BIR) repeats, cysteine-rich domains of
approximately 80 amino acids that bind and inhibit caspases (e.g., CASP3; MIM 600636). XIAP has 3
BIR domains and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase (see MIM 601623)
activity. XAF1 antagonizes the anticaspase activity of XIAP and may be important in mediating
apoptosis resistance in cancer cells (Liston et al., 2001 [PubMed 11175744]).[supplied by OMIM]

UniProtKB/Swiss-Prot: XAF1_HUMAN, Q6GPH4
Function: Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis
protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of
BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in
apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial
apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to
mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of
BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to
occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the
process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to
the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of
cancer cells

Gene Wiki entry for XAF1

Genomic Location
for XAF1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.2   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13.2

XAF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P006601:     (about GC identifiers)

Start:
 6,599,880 bp from pter
End:
 6,619,690 bp from pter
Size:
 19,811 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000017.9  NT_010718.15  

Proteins
for XAF1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: XAF1_HUMAN, Q6GPH4 (See protein sequence)
Recommended Name: XIAP-associated factor 1  
Size: 301 amino acids; 34626 Da
Subunit: Interacts with BIRC4; the interaction is not detected in (PubMed:16432762). Interacts with
BIRC1, BIRC2, BIRC3, BIRC7 and BIRC8. Part of an complex consisting of BIRC4, XAF1 and BIRC5; the
complex formation requires IFN-beta stimulation
Subcellular location: Cytoplasm. Nucleus. Mitochondrion. Note=Found in the cytoplasm and nucleus of
placental syncytiotrophoblasts. Translocates to mitochondria upon TNF-alpha treatment
Subcellular location: Isoform 1: Nucleus
Subcellular location: Isoform 5: Nucleus
Developmental stage: Selectively expressed in third trimester placenta
Sequence caution: Sequence=CAA68030.1; Type=Frameshift; Positions=294;
Secondary accessions: A2T931 A2T932 A8K2L1 A8K9Y3 Q6MZE8 Q8N557 Q99982
Alternative splicing: 7 isoforms:  Q6GPH4-1   Q6GPH4-2   Q6GPH4-3   Q6GPH4-4   Q6GPH4-5   Q6GPH4-6   Q6GPH4-7   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_059993.2  NP_954590.1  


    ENSEMBL proteins: 
    ENSP00000254867 ENSP00000341029 ENSP00000354822 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (XAF1)
    Human Recombinant Proteins from Abnova (XAF1)
                  OriGene Purified Recombinant Human Protein: XAF1 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm IEA--
    GO:0005739 mitochondrion IEA--
    About this table

    Antibodies for XAF1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for XAF1
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (XAF1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (XAF1)
    Novus Biologicals Antibodies for XAF1

    Assays for XAF1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for XAF1

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro domain/family:
     IPR001293 Znf_TRAF


       GeneDecks  XAF1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q6GPH4

    ProtoNet protein and cluster: Q6GPH4

    UniProtKB/Swiss-Prot: XAF1_HUMAN, Q6GPH4
    Similarity: Contains 1 TRAF-type zinc finger

    Gene Function
    for XAF1

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (XAF1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (XAF1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_017523

                  Applied Biosystems Silencer® siRNAs for XAF1

                  Sigma-Aldrich siRNA for XAF1  
                         Sigma-Aldrich shRNA for XAF1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for XAF1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_017523
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_017523
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_017523 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_017523

    UniProtKB/Swiss-Prot: XAF1_HUMAN, Q6GPH4
    Function: Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis
    protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of
    BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in
    apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial
    apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to
    mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of
    BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to
    occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the
    process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to
    the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of
    cancer cells
    Induction: Up-regulated by IFN-beta in cell lines sensitive to the proapoptotic effects of IFN-beta
    but not in apoptosis-resistant cells. Up-regulated by TNF-alhpa in trophoblast cells

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    Pathways & Interactions
    for XAF1

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  XAF1 


    5/8 Interacting proteins for XAF1 (ENSP000002548673) via UniProtKB, MINT, and/or STRING (see all 8 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XIAPENSP000003602423STRING (score=.991)
    BIRC2ENSP000002277583STRING (score=.933)
    BIRC3ENSP000002634643STRING (score=.916)
    STAT1ENSP000003543943STRING (score=.91)
    BIRC7ENSP000002171693STRING (score=.9)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915 apoptosis IEA--
    GO:0045786 negative regulation of cell cycle IEA--
    About this table

    Drugs & Compounds
    for XAF1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for XAF1

    Transcripts
    for XAF1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (XAF1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (XAF1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_017523

                  Sigma-Aldrich siRNA for XAF1  
                         Sigma-Aldrich shRNA for XAF1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_017523  NM_199139  

    REFSEQ mRNAs for XAF1 gene (2 alternative transcripts): 

    NM_017523.2   NM_199139.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_017523  NM_199139  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_017523
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_017523
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_017523 

    Additional cDNA sequence: 

    AK056908.1 AK091799.1 AK128092.1 AK290276.1 AK292710.1 AK292848.1 BC032776.1 BC058017.1 
    BC073156.1 BX648588.1 BX649188.1 EF028165.1 EF028166.1 X99699.1 

    13 DOTS entries:

    DT.70100215  DT.106672  DT.100783882  DT.40247731  DT.100783878  DT.101983944  DT.95300500  DT.100783880 
    DT.120921051  DT.95096626  DT.86838148  DT.86843622  DT.95307618 

    24/153 AceView cDNA sequences (see all 153 ):

    AV649497 AI347382 AA911966 CA398245 BU678951 AI671675 AA361525 NM_199139 
    BF929275 BM984102 AI671656 AA568824 AI583096 AI963638 CB139521 AI148361 
    BM460522 AI352370 AI248567 BQ433816 BQ938147 BC073156 BF111792 BG575167 

    Unigene Cluster for XAF1:

    XIAP associated factor 1
    Hs.441975  [show with all ESTs]
    Unigene Representative Sequence: BX649188


    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for XAF1 (see all 17 )

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a ·
    SP1:                                            -           -     -     -     -     -     -     -           -                       -     -     -     -         
    SP2:                                            -           -     -     -     -     -     -     -           -                       -                           
    SP3:                                            -           -     -     -           -     -     -           -                       -     -     -     -         
    SP4:                                            -           -     -     -     -     -     -     -     -     -                       -     -     -     -         
    SP5:                                            -           -     -     -     -     -     -     -           -                                                   

    ExUns: 12b ^ 13a · 13b ^ 14a · 14b · 14c · 14d
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          

    About this scheme

    ECgene alternative splicing isoforms for XAF1

    3 Ensembl transcripts including schematic representations:
    ENST00000348844  ENST00000346752  ENST00000361842  

    Expression
    for XAF1

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    XAF1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for XAF1

    1 / 2

    9 probe-sets matching XAF1 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		60017_at2 U95-C 1 1.00 1.00 0.97 1.41 -- -- -- -- --
    35583_at2 U95-A 1 1.00 1.00 0.97 0.63 -- -- -- -- --
    80194_at2 U95-E 1 1.00 1.00 0.52 0.98 -- -- -- -- --

    		206133_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --

    		228617_at2 U133-B 1 1.00 1.00 -- -- -- -- -- -- --

    		242234_at2 U133-B 1 1.00 1.00 -- -- -- -- -- -- --

    		206133_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		228617_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		242234_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  XAF1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TGCCCCTGAA

    SOURCE GeneReport for Unigene cluster: Hs.441975

    UniProtKB/Swiss-Prot: XAF1_HUMAN, Q6GPH4
    Tissue specificity: Widely expressed. Expression is frequently down-regulated in cancer cell lines.
    Isoform 5 is widely expressed. Expressed in placenta (at protein level)

    Orthologs
    for XAF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for XAF1 gene from 5/6 species (see all 6 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    chimpanzee
    (Pan troglodytes)    		 XAF11   -- XIAP associated factor 1 98.89(n)
    97.67(a)    		 455244  XM_001168151.1  XP_001168151.1 
    cow
    (Bos taurus)    		 XAF11   -- XIAP associated factor 1 74.77(n)
    60.42(a)    		 509740  NM_001035075.1  NP_001030247.1 
    rat
    (Rattus norvegicus)    		 XAF11   -- XIAP associated factor-1 66.92(n)
    51.35(a)    		 679600  XM_001053682.1  XP_001053682.1 
    mouse
    (Mus musculus)    		 Xaf15 11 XIAP associated factor 1   -- EL957551 
    chicken
    (Gallus gallus)    		 XAF11   -- XIAP associated factor 1 56.3(n)
    43.9(a)    		 417677  XM_415922.2  XP_415922.2 
    About this table        Species with no ortholog for XAF1

    ENSEMBL Gene Tree for XAF1

    Paralogs
    for XAF1

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for XAF1 gene
    TRAFD12  

    SNPs/Variants
    for XAF1

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/144 NCBI SNPs in XAF1 are shown (see all 144 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 93)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 17 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs9554611,2
    		A,C,F,H,O6599693(+) CAACAC/TGGCAA 2 -- ng519Minor allele frequency- T:0.41NA MN EA EU WA 1806
    rs9554621,2
    		A,C,F,H6599870(+) TGCCAC/GCCTCA 2 -- ng519Minor allele frequency- G:0.33EA NA EU WA 644
    rs37857931,2
    		A,C,F,H6600048(+) GGGCCA/GTCGGA 2 -- ut5114Minor allele frequency- N:0.00EA NA MN EU WA 2306
    rs37857921,2
    		C,F,H6599993(+) GGAACT/GCCTGA 2 -- ut5114Minor allele frequency- G:0.16EA NA MN EU WA 3730
    rs177946121,2
    		C,F,H6599091(+) GATTGG/ACCTAG 2 -- ng5112Minor allele frequency- A:0.45NA EA EU WA 1006
    rs37364331,2
    		C,F,H6614834(-) GAAATC/ATGTTT 2 I/R mis113Minor allele frequency- A:0.01EA EU WA 2742
    rs37857901,2
    		C,F,H6599827(+) GGAACA/GAGCTG 2 -- ng5110Minor allele frequency- G:0.15EA NA MN EU WA 3284
    --
    rs72135581,2
    		A,C6598224(+) TTCCtG/Ttcttt 2 -- ng510--------
    --
    rs99114831,2
    		A,C6598826(+) aagccA/CagccC 2 -- ng510--------
    rs341955991,2
    		C,F6604477(-) TACACT/CCAACA 2 G/E mis15Minor allele frequency- C:0.24NA EU EA WA 488
    About this table

    HapMap Linkage Disequilibrium images for XAF1 (up to first 250kb)

    Disorders & Mutations
    for XAF1

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 606717

    6 Novoseek disease relationships for XAF1 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenocarcinoma gastric 59.27 7 17471152 (3), 18807090 (3)
    colon cancer 42.71 4 15843754 (2), 18362468 (1)
    cancer 30.93 13 14612497 (3), 11175744 (2), 15843754 (1), 16343440 (1) (see all 7)
    tumors 29.54 15 15610524 (3), 14612497 (2), 15843754 (1), 16353137 (1) (see all 7)
    melanoma 10.81 11 15610524 (5), 12029096 (2)
    carcinoma 0.00 3 17471152 (2), 14612497 (1)
    About this table

    Medical News
    for XAF1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for XAF1

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/38 PubMed articles for XAF1 gene (see all 38 ):

    Search for XAF1

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing XAF1

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 54739 HGNC: 30932 AceView: HSXIAPAF1 Ensembl:ENSG00000132530 euGenes: HUgn54739
    ECgene: XAF1 H-InvDB: XAF1

    Other Databases showing XAF1

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing XAF1

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for XAF1 Genetics and Cytogenetics in Oncology and Haematology

    Licensable Technologies
    for XAF1

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for XAF1

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for XAF1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for XAF1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for XAF1 Antibodies for XAF1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for XAF1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (XAF1)
     Antibodies (XAF1)
     Chimera RNAi (XAF1)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (XAF1)
     Antibodies (XAF1)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for XAF1




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for XAF1

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

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