Aliases for XAF1 Gene
Aliases for XAF1 Gene
External Ids for XAF1 Gene
- HGNC: 30932
- Entrez Gene: 54739
- Ensembl: ENSG00000132530
- OMIM: 606717
- UniProtKB: Q6GPH4
Previous GeneCards Identifiers for XAF1 Gene
- GC17P006601
- GC17P006659
- GC17P006554
Summaries for XAF1 Gene
-
This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
GeneCards Summary for XAF1 Gene
XAF1 (XIAP Associated Factor 1) is a Protein Coding gene. Diseases associated with XAF1 include Thymic Dysplasia and Thymus Gland Disease. Among its related pathways are Apoptosis and Autophagy and Copper homeostasis. An important paralog of this gene is TRAFD1.
UniProtKB/Swiss-Prot for XAF1 Gene
-
Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for XAF1 Gene
Genomics for XAF1 Gene
Regulatory Elements for XAF1 Gene
Enhancers for XAF1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around XAF1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the XAF1 gene promoter:
Regulatory Element Products
Genomic Location for XAF1 Gene
- Chromosome:
- 17
- Start:
- 6,755,447 bp from pter
- End:
- 6,775,647 bp from pter
- Size:
- 20,201 bases
- Orientation:
- Plus strand
Genomic View for XAF1 Gene
Genes around XAF1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17p13.1 by Ensembl
- 17p13.1 by Entrez Gene
- 17p13.2 by HGNC
XAF1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for XAF1 Gene
Proteins for XAF1 Gene
-
Protein details for XAF1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6GPH4-XAF1_HUMAN
- Recommended name:
- XIAP-associated factor 1
- Protein Accession:
- Q6GPH4
- A2T931
- A2T932
- A8K2L1
- A8K9Y3
- D3DTM6
- Q6MZE8
- Q8N557
- Q99982
Protein attributes for XAF1 Gene
- Size:
- 301 amino acids
- Molecular mass:
- 34626 Da
- Quaternary structure:
-
- Interacts with BIRC4; the interaction is not detected in (PubMed:16432762). Interacts with BIRC1, BIRC2, BIRC3, BIRC7 and BIRC8. Part of an complex consisting of BIRC4, XAF1 and BIRC5; the complex formation requires IFN-beta stimulation. Interacts with RNF114, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.
- SequenceCaution:
-
- Sequence=AAH32776.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA68030.1; Type=Frameshift; Positions=294; Evidence={ECO:0000305};
Protein Expression for XAF1 Gene
Post-translational modifications for XAF1 Gene
Other Protein References for XAF1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for XAF1 (BIRC4BP)
-
Custom Antibody ServicesOriGene Antibodies for XAF1
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-
Abcam antibodies for XAF1
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- antibodies-online Antibodies for XAF1: See all 79
- GeneTex XAF1 antibody for XAF1
-
Custom Antibody ServicesProSci Antibodies for XAF1
-
Santa Cruz Biotechnology (SCBT) Antibodies for XAF1
Protein Products
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OriGene Purified Proteins for XAF1
- Search Origene for MassSpec and Protein Over-expression Lysates for XAF1
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- ProSpec Recombinant Proteins for XAF1
- antibodies-online Proteins for XAF1: See all 8
- Search antibodies-online for peptides
- Search GeneTex for Proteins for XAF1
-
Abcam proteins for XAF1
No data available for DME Specific Peptides for XAF1 Gene
Domains & Families for XAF1 Gene
Protein Domains for XAF1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for XAF1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for XAF1 Gene
Function for XAF1 Gene
Molecular function for XAF1 Gene
- UniProtKB/Swiss-Prot Function:
- Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by IFNB1/IFN-beta in cell lines sensitive to the proapoptotic effects of IFNB1 but not in apoptosis-resistant cells. Up-regulated by TNF in trophoblast cells.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for XAF1 Gene
- GenomeRNAi human phenotypes for XAF1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for XAF1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for XAF1 gene
- Search ViGene Biosciences for XAF1
CRISPR Products
-
OriGene CRISPR knockouts for XAF1
-
Santa Cruz Biotechnology (SCBT) CRISPR for XAF1
- GenScript: Design CRISPR guide RNA sequences for XAF1
miRNA for XAF1 Gene
- miRTarBase miRNAs that target XAF1
miRNA Products
- Search ViGene Biosciences for XAF1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for XAF1
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-
ViGene Biosciences ready-to-package AAV shRNAs for XAF1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for XAF1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for XAF1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for XAF1
-
ViGene Biosciences adenoviral particle packaged cDNA for XAF1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for XAF1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for XAF1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for XAF1 Gene
Localization for XAF1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for XAF1 Gene
- Cytoplasm. Nucleus. Mitochondrion. Note=Found in the cytoplasm and nucleus of placental syncytiotrophoblasts. Translocates to mitochondria upon TNF-alpha treatment.
- Isoform 1: Nucleus.
- Isoform 5: Nucleus.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 2 |
| plasma membrane | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005739 | mitochondrion | IDA | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for XAF1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptosis and Autophagy | ||
| 2 | Cytokine Signaling in Immune system | ||
| 3 | Innate Immune System |
.61
|
|
| 4 | Immune response IFN alpha/beta signaling pathway | ||
| 5 | Interferon gamma signaling | ||
Pathways by source for XAF1 Gene
1 Cell Signaling Technology pathway for XAF1 Gene
1 BioSystems pathway for XAF1 Gene
4 Reactome pathways for XAF1 Gene
Interacting Proteins for XAF1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006915 | apoptotic process | IEA | -- |
| GO:0031333 | negative regulation of protein complex assembly | IEA | -- |
| GO:0035456 | response to interferon-beta | IDA | 18035482 |
| GO:0060337 | type I interferon signaling pathway | TAS | -- |
Drugs & Compounds for XAF1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Embelin | Pharma | XIAP inhibitor,cell-permeable, Inhibitor of X-linked inhibitor of apoptosis (XIAP); cell-permeable and antitumor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for XAF1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Embelin | XIAP inhibitor,cell-permeable | 550-24-3 |
Transcripts for XAF1 Gene
mRNA/cDNA for XAF1 Gene
- (10) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (153) Selected AceView cDNA sequences:
- (19) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for XAF1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for XAF1
-
Santa Cruz Biotechnology (SCBT) CRISPR for XAF1
- GenScript: Design CRISPR guide RNA sequences for XAF1
miRNA Products
- Search ViGene Biosciences for XAF1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for XAF1
- Browse OriGene Inhibitory RNA Products For XAF1
-
ViGene Biosciences ready-to-package AAV shRNAs for XAF1 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for XAF1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for XAF1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | · | 2f | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: |
| ExUns: | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | · | 14d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||
| SP2: | |||||||||||||
| SP3: | |||||||||||||
| SP4: | |||||||||||||
| SP5: | |||||||||||||
| SP6: | |||||||||||||
| SP7: | |||||||||||||
| SP8: | |||||||||||||
| SP9: | |||||||||||||
| SP10: | |||||||||||||
| SP11: | |||||||||||||
| SP12: | |||||||||||||
| SP13: | |||||||||||||
| SP14: | |||||||||||||
| SP15: | |||||||||||||
| SP16: | |||||||||||||
| SP17: |
Expression for XAF1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Myelinating Oligodendrocyte Cells Forebrain White Matter
-
Glial Cells
- Myelinating Oligodendrocyte Cells Forebrain White Matter
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
-
Blood (Cardiovascular System)
- T Helper Cells Thymus
-
Testis (Reproductive System)
- Mature Sertoli Cells Seminiferous Tubules
- Intestine (Gastrointestinal Tract)
- Neural Crest (Gastrulation Derivatives)
- Paraxial Mesoderm (Gastrulation Derivatives)
-
Uterus (Reproductive System)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Ovary (Reproductive System)
This gene is overexpressed in Placenta (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for XAF1 Gene
NURSA nuclear receptor signaling pathways regulating expression of XAF1 Gene:
XAF1SOURCE GeneReport for Unigene cluster for XAF1 Gene:
Hs.441975mRNA Expression by UniProt/SwissProt for XAF1 Gene:
Q6GPH4-XAF1_HUMAN
Tissue specificity:
Widely expressed. Expression is frequently down-regulated in cancer cell lines. Isoform 5 is widely expressed. Expressed in placenta (at protein level).
Evidence on tissue expression from TISSUES for XAF1 Gene
- Intestine(2.3)
- Liver(2.3)
- Lung(2.3)
Primer Products
-
OriGene qPCR primer pairs for XAF1
-
OriGene qPCR primer pairs and template standards for XAF1
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for XAF1 Gene
Orthologs for XAF1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | XAF1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | XAF1 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | XAF1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Xaf1 34 16 35 |
|
||
| dog (Canis familiaris) |
Mammalia | XAF1 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | XAF1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | XAF1 34 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zgc:153893 34 |
|
||
| XAF1 35 |
|
OneToOne |
- Species where no ortholog for XAF1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for XAF1 Gene
(1) SIMAP similar genes for XAF1 Gene using alignment to 9 proteins:
Variants for XAF1 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000272217 | -- | 6,753,591(+) | CCCTC(C/T)GACTC | upstream-variant-2KB | |
| rs1000328839 | -- | 6,764,712(+) | TACCA(A/T)CTTGT | intron-variant | |
| rs1000440989 | -- | 6,771,334(+) | TCTCT(C/T)ATGGT | intron-variant, utr-variant-3-prime | |
| rs1000444193 | -- | 6,758,674(+) | AGGAG(A/G)GATGG | intron-variant | |
| rs1000490335 | -- | 6,775,389(+) | TTTAC(C/T)TATAT | nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2668218 | CNV | deletion | 23128226 |
| nsv1059072 | CNV | loss | 25217958 |
Residual Variation Intolerance Score:
96.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.96;
68.07% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for XAF1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for XAF1 Gene
Disorders for XAF1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| thymic dysplasia |
|
|
| thymus gland disease |
|
|
Search XAF1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for XAF1
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- XAF1
No data available for UniProtKB/Swiss-Prot and Genatlas for XAF1 Gene
Publications for XAF1 Gene
- Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis. (PMID: 12029096) Leaman D.W. … Borden E.C. (J. Biol. Chem. 2002) 2 3 4 22 64
- Identification of XAF1 as an antagonist of XIAP anti-Caspase activity. (PMID: 11175744) Liston P. … Korneluk R.G. (Nat. Cell Biol. 2001) 2 3 4 22 64
- Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complex. (PMID: 17613533) Arora V. … Korneluk R.G. (J. Biol. Chem. 2007) 3 4 22 64
- Identification of a novel splice variant of X-linked inhibitor of apoptosis-associated factor 1. (PMID: 16343440) Yin W. … Clifford J.L. (Biochem. Biophys. Res. Commun. 2006) 3 4 22 64
- ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.). (PMID: 23645206) Han J. … Chi S.G. (Cell Death Differ. 2013) 3 4 64
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- antibodies-online Proteins for XAF1: See all 8
- Search antibodies-online for peptides
- GeneTex XAF1 antibody for XAF1
- Search GeneTex for Proteins for XAF1
- ViGene Biosciences adenoviral particle packaged cDNA for XAF1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for XAF1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for XAF1 gene
- Search ViGene Biosciences for XAF1
- Santa Cruz Biotechnology (SCBT) Antibodies for XAF1
- Search Santa Cruz Biotechnology (SCBT) for XAF1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for XAF1
- Custom Antibody ServicesProSci Antibodies for XAF1
- Search for XAF1 Proteins at ProSci
- Horizon Cell Lines for XAF1
- Cyagen custom Knockout/knockin (KOKI) mouse models for XAF1
- VectorBuilder custom plasmid, inducible vectors for XAF1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for XAF1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for XAF1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer