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Aliases & Descriptions for GPN1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases ATPBD1A 1 , 2 FLJ51176 2 MBDIN 1 , 2 , 3 MBDin 3 NTPBP 1 , 2 XAB1 2 , 3
Descriptions ATP(GTP)-binding protein 2 GPN-loop GTPase 1 2 MBD2-interacting protein 2 , 3 XPA binding protein 1 1 XPA binding protein 1, GTPase 1 , 2 XPA-binding protein 1 3
Search outside databases for aliases for GPN1 gene
Summaries for GPN1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for GPN1 : This gene encodes a guanosine triphosphatase enzyme. The encoded protein may play a role in DNArepair and may function in activation of transcription. Alternatively spliced transcript variantshave been described. [provided by RefSeq] UniProtKB/Swiss-Prot: GPN1_HUMAN, Q9HCN4 Function : Forms an interface between the RNA polymerase II enzyme and chaperone/scaffoldingprotein, suggesting that it is required to connect RNA polymerase II to regulators of proteincomplex formation. May be involved in nuclear localization of XPA
Genomic Location for GPN1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 2p23.3 Ensembl cytogenetic band: 2p23.2 HGNC cytogenetic band: 2p23.3 GPN1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02P027705:
(about GC identifiers )
Start:
27,705,029 bp from pter
End:
27,727,217 bp from pter
Size:
22,189 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000002.10 NT_022184.14 Proteins for GPN1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: GPN1_HUMAN, Q9HCN4 (See
protein sequence )Recommended Name: GPN-loop GTPase 1 Size : 374 amino acids; 41740 Da
Subunit : Tightly associated with the RNA polymerase II complex. Interacts with XPA
Subcellular location : Cytoplasm
Secondary accessions : O76004
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (4 alternative transcripts):
NP_001138519.1 NP_001138520.1 NP_001138521.1 NP_009197.2 ENSEMBL proteins: ENSP00000384255 ENSP00000264718 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 1 Gene Ontology (GO) cellular component term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005737 cytoplasm
IEA --
About this table Antibodies for GPN1: Assays for GPN1:
Protein
Domains/ Families for GPN1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9HCN4 ProtoNet protein and cluster: Q9HCN4
2 Blocks protein families : IPB001806 Transforming protein P21 RAS signature IPB004130 Conserved hypothetical ATP binding protein UniProtKB/Swiss-Prot: GPN1_HUMAN, Q9HCN4 Similarity : Belongs to the GPN-loop GTPase family
Gene Function for GPN1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
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RNAi Products ,
Clones , and
Q-PCR Products
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Millipore ,
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siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5 ): NM_007266 Applied Biosystems Silencer ® siRNAs for GPN1 Sigma-Aldrich siRNA for GPN1 Sigma-Aldrich shRNA for GPN1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 4 ): NM_001145047                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 4 ): NM_001145047                                  untagged cDNA clones in CMV expression vector (see all 4 ): NM_001145047  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_007266 UniProtKB/Swiss-Prot: GPN1_HUMAN, Q9HCN4 Function : Forms an interface between the RNA polymerase II enzyme and chaperone/scaffoldingprotein, suggesting that it is required to connect RNA polymerase II to regulators of proteincomplex formation. May be involved in nuclear localization of XPA
1 MGI phenotypic allele for Gpn1 (no phenotypes)4 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for GPN1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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2 Interacting proteins for GPN1 (Q9HCN4 1 , 2 ) via UniProtKB, MINT, and/or STRING About this table
Drugs & Compounds for GPN1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for GPN1
Transcripts for GPN1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5 ): NM_007266 Sigma-Aldrich siRNA for GPN1 Sigma-Aldrich shRNA for GPN1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_007266
REFSEQ mRNAs for GPN1 gene (4 alternative transcripts): NM_001145047.1 NM_001145048.1 NM_001145049.1 NM_007266.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_007266
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4 ): NM_001145047                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 4 ): NM_001145047                                  untagged cDNA clones in CMV expression vector (see all 4 ): NM_001145047  
Additional cDNA sequence: AB044661.1 AJ010842.1 AK298827.1 AK298866.1 AK302131.1 AK310340.1 AK311423.1 AK312992.1 AK316404.1 BC007451.2 CR602623.1 CR608298.1 CR612976.1 CR617699.1
9 DOTS entries : DT.100802471 DT.100802465 DT.100675496 DT.448385 DT.95135337 DT.95114895 DT.100672702 DT.100802468 DT.100802475
24/238 AceView cDNA sequences (see all 238
):BC007451 AW005665 CA416162 BG419532 BU149889 AA448819 AA291318 BI752213 BX462192 BM810685 AI382707 BQ215762 AA181995 BQ427528 CD107295 AW073406 BM461473 AA884754 CR612976 AW169849 BU166962 AA448818 CR608298 BX441317
Unigene Cluster for GPN1: GPN-loop GTPase 1 Hs.18259 [show with all ESTs ] Unigene Representative Sequence: NM_007266 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for GPN1 (see all 6
) ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b SP1 :             -                               SP2 :             -                   -             SP3 :           -   -   -                             SP4 :           -   -   -   -                           SP5 :                                     -      
About this scheme ECgene alternative splicing isoforms for GPN1 2 Ensembl transcripts including schematic representations : ENST00000407583
ENST00000264718
Expression for GPN1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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GPN1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for GPN1 1 / 2
3 probe-sets matching GPN1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: ATTAATGAATSOURCE GeneReport for Unigene cluster: Hs.18259 UniProtKB/Swiss-Prot: GPN1_HUMAN, Q9HCN4 Tissue specificity : Expressed ubiquitously
Orthologs for GPN1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for GPN1 gene from 5/25 species (see all 25
)
About this table Species with no ortholog for GPN1 ENSEMBL Gene Tree for GPN1 Paralogs for GPN1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for GPN1 gene GPN2 2 GPN3 2
SNPs/Variants for GPN1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for GPN1 (up to first 250kb)
Disorders & Mutations for GPN1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 611479
Medical News for GPN1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for GPN1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/14 PubMed articles for GPN1 gene (see all 14
): Characterization of 16 novel human genes showing high similarity to yeast sequences. (PubMed id 11124703) 2, 3, 4 Stanchi F....Valle G. (2001) A novel cytoplasmic GTPase XAB1 interacts with DNA repair protein XPA. (PubMed id 11058119) 2, 3, 4 Nitta M....Tanaka K. (2000) Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PubMed id 17643375) 3, 4 Jeronimo C....Coulombe B. (2007) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) MBDin, a novel MBD2-interacting protein, relieves MBD2 repression potential and reactivates transcription from methylated promoters. (PubMed id 12588985) 1, 3 Lembo F....Chiariotti L. (2003) Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336) 4 Cantin G.T....Yates J.R. III (2008) Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976) 4 Daub H.... Mann M. (2008) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 4 Dephoure N.... Gygi S.P. (2008) Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross- validation of MS/MS and MS/MS/MS Spectra. (PubMed id 17924679) 4 Yu L.-R.... Veenstra T.D. (2007) Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514) 3 Rual J.F....Vidal M. (2005)
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Genome Databases showing GPN1
(According to
Entrez Gene ,
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AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing GPN1
(According to HUGE )
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Specialized Databases showing GPN1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for GPN1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for GPN1:
Recombinant Proteins (XAB1 ) Antibodies (XAB1 )
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