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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WWTR1 Gene

protein-coding   GIFtS: 55
GCID: GC03M149235

WW domain containing transcription regulator 1
 Explore 11 diseases affiliated with
WWTR1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for WWTR1    

Aliases
for WWTR1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
WW Domain Containing Transcription Regulator 11 2
TAZ1 2 3 5
Transcriptional Coactivator With PDZ-Binding Motif2 3
DKFZp586I14191
Transcriptional Co-Activator With PDZ-Binding Motif2
WW Domain-Containing Transcription Regulator Protein 12

External Ids:    HGNC: 240421   Entrez Gene: 259372   Ensembl: ENSG000000184087   OMIM: 6073925   UniProtKB: Q9GZV53   

Export aliases for WWTR1 gene to outside databases

Previous GC identifers: GC03M150721 GC03M146607


Summaries
for WWTR1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: WWTR1_HUMAN, Q9GZV5
Function: Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that
plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its
regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in
turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene
activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional
machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and
epithelial-mesenchymal transition

Gene Wiki entry for WWTR1


Genomic Views
for WWTR1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WWTR1 gene promoter:
         AhR   USF1   AML1a   LCR-F1   MZF-1   PPAR-alpha   PPAR-gamma1   USF-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WWTR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for WWTR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WWTR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q23-q24   Ensembl cytogenetic band:  3q25.1   HGNC cytogenetic band: 3q23-q24

WWTR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WWTR1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M149235:  view genomic region     (about GC identifiers)

Start:
 149,235,022 bp from pter      End:
 149,454,501 bp from pter
Size:
 219,480 bases      Orientation:
 minus strand

Proteins
for WWTR1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: WWTR1_HUMAN, Q9GZV5 (See protein sequence)
Recommended Name: WW domain-containing transcription regulator protein 1  
Size: 400 amino acids; 44101 Da
Subunit: Binds to SLC9A3R2 via the PDZ motif at the plasma membrane. Binds to YWHAZ in vivo and in vitro through the
phosphoserine-binding motif RSHSSP (By similarity). Interacts (via coiled-coil domain) with SMAD2 (via MH1 domain),
SMAD3 and SMAD4. Interacts with MED15, PAX8 and NKX2-1. Interacts with TEAD1, TEAD2, TEAD3 and TEAD4
Subcellular location: Nucleus. Cytoplasm. Note=Concentrates along specific portions of the plasma membrane, and
accumulates in punctate nuclear bodies. When phosphorylated, is retained in cytoplasm by YWHAZ. Can be retained in the
nucleus by MED15
Secondary accessions: D3DNH7 Q8N3P2 Q9Y3W6

Explore the universe of human proteins at neXtProt for WWTR1: NX_Q9GZV5

Post-translational modifications:

  • Phosphorylated by LATS2 and STK3/MST2. Phosphorylation by LATS2 results in creation of 14-3-3 binding sites, retention
    • in the cytoplasm, and functional inactivation. Phosphorylation results in the inhibition of transcriptional
    coactivation through YWHAZ-mediated nuclear export1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9GZV5

    • WWTR1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001161750.1  NP_001161752.1  NP_056287.1  

    ENSEMBL proteins: 
     ENSP00000419465   ENSP00000353847   ENSP00000419234   ENSP00000418621   ENSP00000417862  
     ENSP00000417339   ENSP00000418580   ENSP00000420120   ENSP00000420159   ENSP00000417984  
    Reactome Protein details: Q9GZV5
    Human Recombinant Protein Products: 
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    Novus Biologicals WWTR1 Proteins
    Novus Biologicals WWTR1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for WWTR1

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS11118213
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--


    WWTR1 for ontologies           About GeneDecksing



    WWTR1 Antibody Products: 
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    Uscn ELISAs and CLIAs for WWTR1

    Protein Domains /
    Families
    for WWTR1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    WWTR1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001202 WW_Rsp5_WWP

    Graphical View of Domain Structure for InterPro Entry Q9GZV5

    ProtoNet protein and cluster: Q9GZV5

    UniProtKB/Swiss-Prot: WWTR1_HUMAN, Q9GZV5
    Domain: The PDZ-binding motif is essential for stimulated gene transcription. It localizes the protein into both
    punctate nuclear foci and plasma membrane-associated complexes (By similarity)
    Domain: Binds to transcription factors via its WW domain
    Similarity: Contains 1 WW domain


    Function
    for WWTR1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: WWTR1_HUMAN, Q9GZV5
    Function: Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that
    plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
    The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its
    regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in
    turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene
    activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional
    machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and
    epithelial-mesenchymal transition

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WWTR1
    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate WWTR1 (see all 48):
    hsa-miR-3152-3p hsa-miR-4254 hsa-miR-376b hsa-miR-548k hsa-miR-29a hsa-miR-200a hsa-miR-624* hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmid: WWTR1 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: WWTR1
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity NAS11118213
    GO:0003714transcription corepressor activity IEA--
    GO:0005515protein binding IPI--
    GO:0042803protein homodimerization activity IEA--


    WWTR1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for WWTR1:
     Decreased viability of wild-ty  Increased S DNA content 

    Animal Models:
         12 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Wwtr1):
     adipose tissue  behavior/neurological  cardiovascular system  digestive/alimentary  growth/size 
     homeostasis/metabolism  immune system  mortality/aging  renal/urinary system  reproductive system 
     respiratory system  skeleton 

    WWTR1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for WWTR1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    		Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer1.00
    		Signaling by TGF-beta Receptor Complex0.61
    		SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription0.63
    2Generic Transcription Pathway
    		Generic Transcription Pathway1.00
    		Gene Expression0.46
    3Wnt / Hedgehog / Notch
    		Wnt / Hedgehog / Notch1.00
    4Tyrosine Kinases / Adaptors
    		Tyrosine Kinases / Adaptors1.00
    5YAP1- and WWTR1 (TAZ)-stimulated gene expression
    		YAP1- and WWTR1 (TAZ)-stimulated gene expression1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for WWTR1
        Wnt / Hedgehog / Notch
    Tyrosine Kinases / Adaptors
    PI3K / Akt Signaling

    1 BioSystems Pathway for WWTR1 
        Adipogenesis

    5/8        Reactome Pathways for WWTR1 (see all 8)
        Signaling by TGF-beta Receptor Complex
    Signaling by Hippo
    Generic Transcription Pathway
    Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    Signal Transduction



    WWTR1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WWTR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/67 Interacting proteins for WWTR1 (Q9GZV51, 2, 3 ENSP000003538474) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAEP622582, 3, ENSP000002643354MINT-8008218 MINT-8007163 I2D: score=6 STRING: ENSP00000264335
    MED28Q9H2042, 3, ENSP000002373804MINT-7041925 I2D: score=1 STRING: ENSP00000237380
    TJP1Q071572, 3, ENSP000002815374MINT-7994988 I2D: score=1 STRING: ENSP00000281537
    CTNNB1P352222, 3MINT-8384177 I2D: score=1 
    TEAD4Q155611, 3, ENSP000003529264EBI-747743,EBI-747736 I2D: score=5 STRING: ENSP00000352926
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001649osteoblast differentiation IEA--
    GO:0001933negative regulation of protein phosphorylation IMP--
    GO:0006351transcription, DNA-dependent TAS--
    GO:0006355regulation of transcription, DNA-dependent NAS11118213


    WWTR1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for WWTR1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WWTR1
    Search CenterWatch for drugs/clinical trials and news about WWTR1 

    Transcripts
    for WWTR1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for WWTR1 gene (3 alternative transcripts): 
    NM_001168278.1  NM_001168280.1  NM_015472.4  

    Unigene Cluster for WWTR1:

    WW domain containing transcription regulator 1
    Hs.594912  [show with all ESTs]
    Unigene Representative Sequence: NM_015472
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000465804(uc003exe.3 uc021xfm.1 uc003exf.3 uc003exh.3)
    ENST00000360632 ENST00000467467 ENST00000471586 ENST00000494754 ENST00000472417
    ENST00000485244 ENST00000479238 ENST00000485352 ENST00000475579 ENST00000460517
    ENST00000474080

    miRNA
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    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate WWTR1 (see all 48):
    hsa-miR-3152-3p hsa-miR-4254 hsa-miR-376b hsa-miR-548k hsa-miR-29a hsa-miR-200a hsa-miR-624* hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmid: WWTR1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WWTR1 (see all 7)
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    Clone
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    Additional cDNA sequence: 

    AK022036.1 AK025216.1 AK130514.1 AL050107.1 AL833852.1 BC014052.2 BC066916.1 

    15 DOTS entries:

    DT.100797655  DT.100677915  DT.452025  DT.100797648  DT.100028870  DT.95334919  DT.100731551  DT.101974995 
    DT.120877335  DT.95131158  DT.100797651  DT.120877390  DT.40128602  DT.99986814  DT.95301031 

    24/336 AceView cDNA sequences (see all 336):

    BM840191 AI417046 AI817439 BQ024167 CD627026 BU174955 AI491787 BQ435011 
    CN482768 BE277160 AA307382 BU727440 R63898 AW264155 BM677279 BM461884 
    CR608322 AJ299431 BU623639 CA421519 BC014052 CA424600 AK127620 BU552431 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for WWTR1 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
    SP1:                                                                                                              -     -                                 
    SP2:                                                                                                                    -                                 
    SP3:                                                                                                                                                      
    SP4:                                      -     -                                   -                                                                     
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for WWTR1

    Expression
    for WWTR1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WWTR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACGTAATTAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See WWTR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WWTR1

    SOURCE GeneReport for Unigene cluster: Hs.594912

    UniProtKB/Swiss-Prot: WWTR1_HUMAN, Q9GZV5
    Tissue specificity: Highly expressed in kidney, heart, placenta and lung. Expressed in the thyroid tissue

        SABiosciences Expression via Pathway-Focused PCR Array including WWTR1: 
              Primary Cilia in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for WWTR1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for WWTR1 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Wwtr11 , 5 WW domain containing transcription regulator 11, 5 89.03(n)1
    92.41(a)1    		   3 (27.74 cM)5
    970641  NM_001168281.11  NP_001161753.11 
     574556495 
    chicken
    (Gallus gallus)    		 Aves LOC1008599021 WW domain-containing transcription regulator protein more 76.86(n)
    81.35(a)    		   100859902  XM_003641786.1  XP_003641834.1 
    lizard
    (Anolis carolinensis)    		 Reptilia WWTR16
    		 --
    		 82(a)
    		 1 ↔ 1
    		 3(18832973-18928323)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.87432 Transcribed sequence with moderate similarity to protein more 78(n)    142034086 
    zebrafish
    (Danio rerio)    		 Actinopterygii wwtr11 WW domain containing transcription regulator 1 68.31(n)
    67.27(a)    		   568008  NM_001037696.1  NP_001032785.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta yki6
    		 yorkie
    		 20(a)
    		 1 → many
    		 2R(19953498-19956008)


    ENSEMBL Gene Tree for WWTR1 (if available)
    TreeFam Gene Tree for WWTR1 (if available) 

    Paralogs
    for WWTR1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WWTR1 gene
    YAP12  
    3 SIMAP similar genes for WWTR1 using alignment to 8 protein entries:     WWTR1_HUMAN (see all proteins):
    YAP1    YAP    DKFZp451O0517

    WWTR1 for paralogs           About GeneDecksing



    Genomic Variants
    for WWTR1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3407 NCBI SNPs in WWTR1 are shown (see all 3407)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1454995421,2
    		--149234616(+) CTGGGC/TTCAAG 3 -- int10--------
    rs1476912231,2
    		--149234664(+) ACAGGA/CATAAG 3 -- int10--------
    rs1407229301,2
    		--149234823(+) GACATG/TGTAAA 3 -- int10--------
    rs1819284151,2
    		--149234855(+) GTGAAC/TATTTA 3 -- int10--------
    rs1497602591,2
    		--149234904(+) TGCCTA/GCAGAT 3 -- int10--------
    rs1857272471,2
    		--149234984(+) TAAAAA/GGAACA 3 -- int10--------
    rs1458787071,2
    		C,--149235129(+) ACTTTC/TGGTAC 3 -- ut310--------
    rs1905521681,2
    		--149235164(+) GAAATG/TTTTAT 3 -- ut310--------
    rs85731,2
    		C,F,H,--149235302(+) CTTATT/CTTTTT 3 -- ut319Minor allele frequency- C:0.05MN NS EA NA WA 914
    rs1489987501,2
    		--149235356(+) GAGAAC/TACAAC 3 -- ut310--------

    HapMap Linkage Disequilibrium report for WWTR1 (149235022 - 149454501 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for WWTR1
         8 CNVs: 44087 91640 98485 59097 63621 6215 79964 48020
         1 Indel: 79965

    1 SABiosciences Cancer Mutation PCR Assay for WWTR1:
    Cosmic IdAA Change
    51602p.F299V
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WWTR1
    DNA2.0 Custom Variant and Variant Library Synthesis for WWTR1

    Disorders / Diseases
    for WWTR1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    WWTR1 for disorders           About GeneDecksing

    OMIM gene information: 607392    OMIM disorders: --

    11 diseases for WWTR1:    About MalaCards
    polycystic kidney disease    hellp syndrome    hemangioendothelioma    kidney disease
    multiple myeloma    noma    myeloma    breast cancer
    atherosclerosis    thyroiditis    malignant glioma

    Human Genome Epidemiology (HuGE) Navigator: WWTR1 (2 documents)

    Export disorders for WWTR1 gene to outside databases

    Publications
    for WWTR1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WWTR1 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with WWTR1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. (PubMed id 11118213)1, 2, 3, 9 Kanai F....Yaffe M.B. (2000)
    2. TEAD transcription factors mediate the function of TA Z in cell growth and epithelial-mesenchymal transition. (PubMed id 19324877)1, 2 Zhang H....Guan K.L. (2009)
    3. TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation. (PubMed id 19010321)1, 2 Di Palma T....Zannini M. (2009)
    4. TAZ promotes cell proliferation and epithelial-mesenc hymal transition and is inhibited by the hippo pathway. (PubMed id 18227151)1, 2 Lei Q.Y....Guan K.L. (2008)
    5. TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. (PubMed id 18568018)1, 2 Varelas X....Wrana J.L. (2008)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Heterogeneous nuclear ribonuclear protein U associates with YAP and regulates its co-activation of Bax transcription. (PubMed id 15096513)1, 3 Howell M....Milgram S.L. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells. (PubMed id 18413727)1, 9 Chan S.W....Hong W. (2008)
    10. Elevated tumor necrosis factor-alpha suppresses TAZ expression and impairs osteogenic potential of Flk-1+ mesenchymal stem cells in patients with multiple myeloma. (PubMed id 17927494)1, 9 Li B....Zhao R.C. (2007)

    External Searches for WWTR1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing WWTR1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25937 HGNC: 24042 AceView: TAZ.1 Ensembl:ENSG00000018408 euGenes: HUgn25937
    ECgene: WWTR1 H-InvDB: WWTR1

    Other Databases showing WWTR1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing WWTR1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WWTR1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for WWTR1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for WWTR1 gene:
    Search GeneIP for patents involving WWTR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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