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WWTR1 Gene

protein-coding   GIFtS: 58
GCID: GC03M149235

WW Domain Containing Transcription Regulator 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WW Domain Containing Transcription Regulator 11 2
TAZ2 3 5
Transcriptional Coactivator With PDZ-Binding Motif2 3
Transcriptional Co-Activator With PDZ-Binding Motif2
WW Domain-Containing Transcription Regulator Protein 12

External Ids:    HGNC: 240421   Entrez Gene: 259372   Ensembl: ENSG000000184087   OMIM: 6073925   UniProtKB: Q9GZV53   

Export aliases for WWTR1 gene to outside databases

Previous GC identifers: GC03M150721 GC03M146607


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for WWTR1 Gene:
WWTR1 (WW domain containing transcription regulator 1) is a protein-coding gene. Diseases associated with WWTR1 include epithelioid hemangioendothelioma, and hemangioendothelioma. GO annotations related to this gene include transcription corepressor activity and protein homodimerization activity. An important paralog of this gene is YAP1.

UniProtKB/Swiss-Prot: WWTR1_HUMAN, Q9GZV5
Function: Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway
that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting
apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex
with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein
MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and
NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling
them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal,
promotes cell proliferation and epithelial-mesenchymal transition

Gene Wiki entry for WWTR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the WWTR1 gene promoter:
         AhR   USF1   AML1a   LCR-F1   MZF-1   PPAR-alpha   PPAR-gamma1   USF-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWWTR1 promoter sequence
   Search Chromatin IP Primers for WWTR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WWTR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q23-q24   Ensembl cytogenetic band:  3q25.1   HGNC cytogenetic band: 3q23-q24

WWTR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WWTR1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M149235:  view genomic region     (about GC identifiers)

Start:
149,235,022 bp from pter      End:
149,454,501 bp from pter
Size:
219,480 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: WWTR1_HUMAN, Q9GZV5 (See protein sequence)
Recommended Name: WW domain-containing transcription regulator protein 1  
Size: 400 amino acids; 44101 Da
Subunit: Binds to SLC9A3R2 via the PDZ motif at the plasma membrane. Binds to YWHAZ in vivo and in vitro through
the phosphoserine-binding motif RSHSSP (By similarity). Interacts (via coiled-coil domain) with SMAD2 (via MH1
domain), SMAD3 and SMAD4. Interacts with MED15, PAX8 and NKX2-1. Interacts with TEAD1, TEAD2, TEAD3 and TEAD4
Secondary accessions: D3DNH7 Q8N3P2 Q9Y3W6

Explore the universe of human proteins at neXtProt for WWTR1: NX_Q9GZV5

Explore proteomics data for WWTR1 at MOPED

Post-translational modifications: 

  • Phosphorylated by LATS2 and STK3/MST2. Phosphorylation by LATS2 results in creation of 14-3-3 binding sites,
    retention in the cytoplasm, and functional inactivation. Phosphorylation results in the inhibition of
    transcriptional coactivation through YWHAZ-mediated nuclear export1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See WWTR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001161750.1  NP_001161752.1  NP_056287.1  

    ENSEMBL proteins: 
     ENSP00000419465   ENSP00000353847   ENSP00000419234   ENSP00000418621   ENSP00000417862  
     ENSP00000417339   ENSP00000418580   ENSP00000420120   ENSP00000420159   ENSP00000417984  
    Reactome Protein details: Q9GZV5

    WWTR1 Human Recombinant Protein Products:

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    Novus Biologicals WWTR1 Proteins
    Novus Biologicals WWTR1 Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WWTR1

    WWTR1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for WWTR1 (TAZ/WWTR1)
    Cell Signaling Technology (CST) Antibodies for WWTR1  (TAZ)
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    Novus Biologicals WWTR1 Antibodies
    Abcam antibodies for WWTR1
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    ThermoFisher Antibody for WWTR1
    LSBio Antibodies in human, mouse, rat for WWTR1

    WWTR1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for WWTR1
    Cloud-Clone Corp. CLIAs for WWTR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001202 WW_dom

    Graphical View of Domain Structure for InterPro Entry Q9GZV5

    ProtoNet protein and cluster: Q9GZV5

    UniProtKB/Swiss-Prot: WWTR1_HUMAN, Q9GZV5
    Domain: The PDZ-binding motif is essential for stimulated gene transcription. It localizes the protein into both
    punctate nuclear foci and plasma membrane-associated complexes (By similarity)
    Domain: Binds to transcription factors via its WW domain
    Similarity: Contains 1 WW domain


    WWTR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WWTR1_HUMAN, Q9GZV5
    Function: Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway
    that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting
    apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex
    with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein
    MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and
    NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling
    them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal,
    promotes cell proliferation and epithelial-mesenchymal transition

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity NAS11118213
    GO:0003714transcription corepressor activity IEA--
    GO:0005515protein binding IPI16099986
    GO:0042803protein homodimerization activity IEA--
         
    WWTR1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for WWTR1:
     Decreased viability of wild-ty  Increased S DNA content 

         14 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Wwtr1):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     growth/size/body  homeostasis/metabolism  immune system  mortality/aging  muscle 
     renal/urinary system  reproductive system  respiratory system  skeleton 

    WWTR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Wwtr1tm1.2Eno for WWTR1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WWTR1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for WWTR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WWTR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WWTR1

    miRNA
    Products:
        
    miRTarBase miRNAs that target WWTR1:
    hsa-mir-335-5p (MIRT018450), hsa-mir-193b-3p (MIRT016501), hsa-mir-18a-5p (MIRT050729)

    Block miRNA regulation of human, mouse, rat WWTR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WWTR1 (see all 48):
    hsa-miR-3152-3p hsa-miR-4254 hsa-miR-376b hsa-miR-548k hsa-miR-29a hsa-miR-200a hsa-miR-624* hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidWWTR1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for WWTR1
    Predesigned siRNA for gene silencing in human, mouse, rat WWTR1

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for WWTR1 (see all 18)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): WWTR1 (NM_015472)
    Browse Sino Biological Human cDNA Clones
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    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for WWTR1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WWTR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WWTR1_HUMAN, Q9GZV5: Nucleus. Cytoplasm. Note=Concentrates along specific portions of the plasma membrane, and
    accumulates in punctate nuclear bodies. When phosphorylated, is retained in cytoplasm by YWHAZ. Can be retained
    in the nucleus by MED15
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS11118213
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    WWTR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WWTR1 About   (see all 13)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Loss of Function of SMAD2/3 in Cancer
    Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer0.72
    Signaling by TGF-beta Receptor Complex0.60
    SMAD2/SMAD3-SMAD4 heterotrimer regulates transcription0.72
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD2/3 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    2Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    3Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    4Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    5Signaling by GPCR
    Signal Transduction0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for WWTR1
        Wnt / Hedgehog / Notch
    Tyrosine Kinases / Adaptors
    PI3K / Akt Signaling

    1 BioSystems Pathway for WWTR1
        Adipogenesis

    4 Reactome Pathways for WWTR1
        Signaling by Hippo
    PPARA activates gene expression
    YAP1- and WWTR1 (TAZ)-stimulated gene expression
    SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription


    1 Kegg Pathway  (Kegg details for WWTR1):
        Hippo signaling pathway


    WWTR1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including WWTR1: 
              Primary Cilia in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for WWTR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WWTR1 (Q9GZV51, 2, 3 ENSP000003538474) via UniProtKB, MINT, STRING, and/or I2D (see all 99)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAEP622581, 2, 3, ENSP000002643354EBI-747743,EBI-356498 MINT-8008218 MINT-8007163 I2D: score=6 STRING: ENSP00000264335
    CTNNB1P352221, 2, 3EBI-747743,EBI-491549 MINT-8384177 I2D: score=1 
    MED28Q9H2042, 3, ENSP000002373804MINT-7041925 I2D: score=1 STRING: ENSP00000237380
    TJP1Q071572, 3, ENSP000002815374MINT-7994988 I2D: score=1 STRING: ENSP00000281537
    TEAD4Q155611, 3, ENSP000003529264EBI-747743,EBI-747736 I2D: score=5 STRING: ENSP00000352926
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001649osteoblast differentiation IEA--
    GO:0001933negative regulation of protein phosphorylation IMP--
    GO:0006351transcription, DNA-templated TAS--
    GO:0006355regulation of transcription, DNA-templated NAS11118213

    WWTR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WWTR1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for WWTR1 gene (3 alternative transcripts): 
    NM_001168278.1  NM_001168280.1  NM_015472.4  

    Unigene Cluster for WWTR1:

    WW domain containing transcription regulator 1
    Hs.477921  [show with all ESTs]
    Unigene Representative Sequence: NM_015472
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000465804(uc003exe.3 uc021xfm.1 uc003exf.3 uc003exh.3)
    ENST00000360632 ENST00000467467 ENST00000471586 ENST00000494754 ENST00000472417
    ENST00000485244 ENST00000479238 ENST00000485352 ENST00000475579 ENST00000460517
    ENST00000474080
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate WWTR1 (see all 48):
    hsa-miR-3152-3p hsa-miR-4254 hsa-miR-376b hsa-miR-548k hsa-miR-29a hsa-miR-200a hsa-miR-624* hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidWWTR1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat WWTR1
    Clone
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    OriGene ORF clones in mouse, rat for WWTR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): WWTR1 (NM_015472)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WWTR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WWTR1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for WWTR1
    OriGene qSTAR qPCR primer pairs in human, mouse for WWTR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WWTR1
      QuantiTect SYBR Green Assays in human, mouse, rat WWTR1
      QuantiFast Probe-based Assays in human, mouse, rat WWTR1

    Additional mRNA sequence: 

    AK022036.1 AK025216.1 AK130514.1 AL050107.1 AL833852.1 BC014052.2 BC066916.1 

    15 DOTS entries:

    DT.100797655  DT.100677915  DT.452025  DT.100797648  DT.100028870  DT.95334919  DT.100731551  DT.101974995 
    DT.95131158  DT.100797651  DT.120877335  DT.40128602  DT.99986814  DT.120877390  DT.95301031 

    Selected AceView cDNA sequences (see all 336):

    BG777495 NM_015472 BI495942 AW304150 AI984414 AI362106 AK127620 R63898 
    AI142799 BU154953 BQ003163 BU552431 AI417046 BM721683 AI754954 BE407842 
    BU174955 CA424600 AW264155 AW450436 AA948646 AI817439 BC014052 AA128644 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for WWTR1 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
    SP1:                                                                                                              -     -                                 
    SP2:                                                                                                                    -                                 
    SP3:                                                                                                                                                      
    SP4:                                      -     -                                   -                                                                     
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for WWTR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    WWTR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGTAATTAG
    WWTR1 Expression
    About this image


    WWTR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    WWTR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WWTR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.477921

    UniProtKB/Swiss-Prot: WWTR1_HUMAN, Q9GZV5
    Tissue specificity: Highly expressed in kidney, heart, placenta and lung. Expressed in the thyroid tissue

        Pathway & Disease-focused RT2 Profiler PCR Array including WWTR1: 
              Primary Cilia in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for WWTR1
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    QuantiFast Probe-based Assays in human, mouse, rat WWTR1
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WWTR1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wwtr11 , 5 WW domain containing transcription regulator 11, 5 89.09(n)1
    92.67(a)1
      3 (27.74 cM)5
    970641  NM_001168281.11  NP_001161753.11 
     574556495 
    chicken
    (Gallus gallus)
    Aves WWTR11 WW domain containing transcription regulator 1 77.22(n)
    81.65(a)
      100859902  XM_003641786.2  XP_003641834.1 
    lizard
    (Anolis carolinensis)
    Reptilia WWTR16
    WW domain containing transcription regulator 1
    78(a)
    1 ↔ 1
    3(18832973-18930646)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.87432 Transcribed sequence with moderate similarity to protein more 78(n)    142034086 
    zebrafish
    (Danio rerio)
    Actinopterygii wwtr11 WW domain containing transcription regulator 1 69.06(n)
    67.82(a)
      568008  NM_001037696.1  NP_001032785.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta yki6
    yorkie
    15(a)
    1 → many
    2R(19953498-19956008)


    ENSEMBL Gene Tree for WWTR1 (if available)
    TreeFam Gene Tree for WWTR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WWTR1 gene
    YAP12  
    2 SIMAP similar genes for WWTR1 using alignment to 8 protein entries:     WWTR1_HUMAN (see all proteins):
    YAP1    DKFZp451O0517

    WWTR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WWTR1 (see all 3797)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2074638751,2
    Cuntested1149386252(+) TAGCCA/GGGCAT 1 -- int10--------
    rs1454995421,2
    C--149234616(+) CTGGGC/TTCAAG 3 -- int10--------
    rs1476912231,2
    --149234664(+) ACAGGA/CATAAG 3 -- int10--------
    rs1407229301,2
    --149234823(+) GACATG/TGTAAA 3 -- int10--------
    rs1819284151,2
    --149234855(+) GTGAAC/TATTTA 3 -- int10--------
    rs1497602591,2
    --149234904(+) TGCCTA/GCAGAT 3 -- int10--------
    rs1857272471,2
    --149234984(+) TAAAAA/GGAACA 3 -- int10--------
    rs1458787071,2
    C--149235129(+) ACTTTC/TGGTAC 3 -- ut310--------
    rs1905521681,2
    --149235164(+) GAAATG/TTTTAT 3 -- ut310--------
    rs85731,2
    C,F,H--149235302(+) CTTATT/CTTTTT 3 -- ut319Minor allele frequency- C:0.05MN NS EA NA WA 914

    HapMap Linkage Disequilibrium report for WWTR1 (149235022 - 149454501 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for WWTR1 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv996267CNV Deletion20482838
    esv2726042CNV Deletion23290073
    esv2670574CNV Deletion23128226
    esv2726043CNV Deletion23290073
    esv2311493CNV Deletion18987734
    esv2674585CNV Deletion23128226
    esv2483367CNV Deletion19546169
    esv271645CNV Insertion20981092
    nsv4057CNV Insertion18451855
    nsv522752CNV Loss19592680

    1 Site Specific Mutation Identification with PCR Assay for WWTR1:
    Cosmic IdAA Change
    51602p.F299V
    SeqTarget long-range PCR primers for resequencing WWTR1
    DNA2.0 Custom Variant and Variant Library Synthesis for WWTR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607392    OMIM disorders: --

    18 diseases for WWTR1:    
    About MalaCards
    epithelioid hemangioendothelioma    hemangioendothelioma    hellp syndrome    noma
    polycystic kidney disease    kidney disease    papillary thyroid carcinoma    malignant glioma
    pre-eclampsia    eclampsia    hyperglycemia    myeloma
    multiple myeloma    atherosclerosis    thyroiditis    colorectal cancer
    lung cancer    breast cancer


    WWTR1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): WWTR1
    Human Genome Epidemiology (HuGE) Navigator: WWTR1 (2 documents)

    Export disorders for WWTR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WWTR1 gene, integrated from 10 sources (see all 68):
    (articles sorted by number of sources associating them with WWTR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. (PubMed id 11118213)1, 2, 3, 9 Kanai F....Yaffe M.B. (EMBO J. 2000)
    2. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. (PubMed id 19324877)1, 2 Zhang H.... Guan K.L. (J. Biol. Chem. 2009)
    3. Integrative predictive model of coronary artery calcification in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (Circulation 2009)
    4. TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation. (PubMed id 19010321)1, 2 Di Palma T.... Zannini M. (Exp. Cell Res. 2009)
    5. TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. (PubMed id 18568018)1, 2 Varelas X.... Wrana J.L. (Nat. Cell Biol. 2008)
    6. TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway. (PubMed id 18227151)1, 2 Lei Q.Y.... Guan K.L. (Mol. Cell. Biol. 2008)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Heterogeneous nuclear ribonuclear protein U associates with YAP and regulates its co-activation of Bax transcription. (PubMed id 15096513)1, 3 Howell M....Milgram S.L. (J. Biol. Chem. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells. (PubMed id 18413727)1, 9 Chan S.W....Hong W. (Cancer Res. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25937 HGNC: 24042 AceView: TAZ.1 Ensembl:ENSG00000018408 euGenes: HUgn25937
    ECgene: WWTR1 Kegg: 25937 H-InvDB: WWTR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WWTR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WWTR1 gene:
    Search GeneIP for patents involving WWTR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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