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Aliases for WWP2 Gene

Aliases for WWP2 Gene

  • WW Domain Containing E3 Ubiquitin Protein Ligase 2 2 3
  • AIP2 3 4
  • NEDD4-Like E3 Ubiquitin-Protein Ligase WWP2 3
  • Atrophin-1 Interacting Protein 2 3
  • Atrophin-1-Interacting Protein 2 4
  • WW Domain-Containing Protein 2 4
  • EC 6.3.2.- 4
  • WWp2-Like 3
  • EC 6.3.2 64

External Ids for WWP2 Gene

Summaries for WWP2 Gene

Entrez Gene Summary for WWP2 Gene

  • This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10. [provided by RefSeq, Jul 2012]

GeneCards Summary for WWP2 Gene

WWP2 (WW Domain Containing E3 Ubiquitin Protein Ligase 2) is a Protein Coding gene. Diseases associated with WWP2 include campomelic dysplasia. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis and SMAD Signaling Network. GO annotations related to this gene include transcription factor binding and RNA polymerase II transcription factor binding. An important paralog of this gene is AREL1.

UniProtKB/Swiss-Prot for WWP2 Gene

  • E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by Lys-63-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.

Gene Wiki entry for WWP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WWP2 Gene

Genomics for WWP2 Gene

Genomic Location for WWP2 Gene

Start:
69,762,284 bp from pter
End:
69,941,741 bp from pter
Size:
179,458 bases
Orientation:
Plus strand

Genomic View for WWP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WWP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WWP2 Gene

Regulatory Elements for WWP2 Gene

Proteins for WWP2 Gene

  • Protein details for WWP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00308-WWP2_HUMAN
    Recommended name:
    NEDD4-like E3 ubiquitin-protein ligase WWP2
    Protein Accession:
    O00308
    Secondary Accessions:
    • A6NEP1
    • B2R706
    • B4DTL5
    • F5H213
    • H3BRF3
    • I3RSG8
    • Q6ZTQ5
    • Q96CZ2
    • Q9BWN6

    Protein attributes for WWP2 Gene

    Size:
    870 amino acids
    Molecular mass:
    98912 Da
    Quaternary structure:
    • Interacts with POU5F1, RBP1, EGR2 and SLC11A2 (By similarity). Interacts with SCNN1A, SCNN1B, SCNN1G, WBP1, WBP2, ATN1 and adenovirus type 2 PIII. Interacts with ERBB4, NDFIP1 AND NDFIP2.
    Miscellaneous:
    • A cysteine residue is required for ubiquitin-thioester formation
    SequenceCaution:
    • Sequence=BAC86528.1; Type=Frameshift; Positions=757; Evidence={ECO:0000305};

    Alternative splice isoforms for WWP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WWP2 Gene

Proteomics data for WWP2 Gene at MOPED

Post-translational modifications for WWP2 Gene

  • Autoubiquitinated. Ubiquitinated by the SCF(FBXL15) complex, leading to its degradation by the proteasome.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys632

Domains for WWP2 Gene

UniProtKB/Swiss-Prot:

WWP2_HUMAN
Domain:
  • The C2 domain is involved in autoinhibition of the catalytic activity by interacting with the HECT domain.:
    • O00308
  • Contains 1 C2 domain.:
    • O00308
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.:
    • O00308
  • Contains 4 WW domains.:
    • O00308
genes like me logo Genes that share domains with WWP2: view

No data available for Gene Families for WWP2 Gene

Function for WWP2 Gene

Molecular function for WWP2 Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Activated by NDFIP1- and NDFIP2-binding
UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by Lys-63-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.

Enzyme Numbers (IUBMB) for WWP2 Gene

Gene Ontology (GO) - Molecular Function for WWP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001085 RNA polymerase II transcription factor binding ISS 15047715
GO:0004842 ubiquitin-protein transferase activity IMP 18776082
GO:0005515 protein binding IPI 16189514
GO:0008134 transcription factor binding IPI 19651900
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with WWP2: view

Phenotypes for WWP2 Gene

genes like me logo Genes that share phenotypes with WWP2: view

miRNA for WWP2 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for WWP2 Gene

Localization for WWP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WWP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WWP2 Gene COMPARTMENTS Subcellular localization image for WWP2 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for WWP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex TAS 9647693
GO:0005634 nucleus IDA 19274063
GO:0005737 cytoplasm ISS 15047715
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with WWP2: view

Pathways for WWP2 Gene

genes like me logo Genes that share pathways with WWP2: view

Pathways by source for WWP2 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for WWP2 Gene
1 KEGG pathway for WWP2 Gene

UniProtKB/Swiss-Prot O00308-WWP2_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for WWP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS 15047715
GO:0006464 cellular protein modification process TAS 9169421
GO:0010629 negative regulation of gene expression IMP 18776082
GO:0016567 protein ubiquitination IDA 18776082
GO:0032410 negative regulation of transporter activity IDA 18776082
genes like me logo Genes that share ontologies with WWP2: view

Compounds for WWP2 Gene

(4) HMDB Compounds for WWP2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with WWP2: view

Transcripts for WWP2 Gene

Unigene Clusters for WWP2 Gene

WW domain containing E3 ubiquitin protein ligase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WWP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a ·
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10: -
SP11:

ExUns: 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for WWP2 Gene

GeneLoc Exon Structure for
WWP2
ECgene alternative splicing isoforms for
WWP2

Expression for WWP2 Gene

mRNA expression in normal human tissues for WWP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WWP2 Gene

This gene is overexpressed in Artery - Aorta (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WWP2 Gene

SOURCE GeneReport for Unigene cluster for WWP2 Gene Hs.408458

mRNA Expression by UniProt/SwissProt for WWP2 Gene

O00308-WWP2_HUMAN
Tissue specificity: Detected in heart, throughout the brain, placenta, lung, liver, muscle, kidney and pancreas. Also detected in spleen and peripheral blood leukocytes.
genes like me logo Genes that share expressions with WWP2: view

Orthologs for WWP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WWP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WWP2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WWP2 36
  • 91.03 (n)
  • 95.29 (a)
WWP2 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WWP2 36
  • 91.92 (n)
  • 96.55 (a)
WWP2 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wwp2 36
  • 89.85 (n)
  • 95.98 (a)
Wwp2 16
Wwp2 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WWP2 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WWP2 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wwp2 36
  • 89.96 (n)
  • 95.75 (a)
chicken
(Gallus gallus)
Aves WWP2 36
  • 78.6 (n)
  • 84.81 (a)
WWP2 37
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WWP2 37
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wwp2 36
  • 73.99 (n)
  • 84.98 (a)
zebrafish
(Danio rerio)
Actinopterygii idibd1121 36
wwp2 36
  • 72.07 (n)
  • 78.14 (a)
wwp2 37
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Su(dx) 37
  • 51 (a)
OneToMany
Su(dx) 38
  • 67 (a)
worm
(Caenorhabditis elegans)
Secernentea wwp-1 37
  • 56 (a)
OneToMany
Y65B4BR.4a 38
  • 64 (a)
Y65B4BR.4b 38
  • 64 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSP5 37
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9326 37
  • 71 (a)
OneToMany
Species with no ortholog for WWP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WWP2 Gene

ENSEMBL:
Gene Tree for WWP2 (if available)
TreeFam:
Gene Tree for WWP2 (if available)

Paralogs for WWP2 Gene

Paralogs for WWP2 Gene

Selected SIMAP similar genes for WWP2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for WWP2 Gene

genes like me logo Genes that share paralogs with WWP2: view

Variants for WWP2 Gene

Sequence variations from dbSNP and Humsavar for WWP2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs904802 -- 69,936,468(+) GGCGC(C/T)GGGGG intron-variant
rs904803 -- 69,936,626(+) AACCA(A/G)AGCCG intron-variant
rs904804 -- 69,926,702(-) TCCCC(A/G)AGCTG intron-variant
rs904805 -- 69,926,589(-) GTACC(C/T)TGCAG intron-variant
rs904806 -- 69,926,361(-) TCTGC(C/T)GGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WWP2 Gene

Variant ID Type Subtype PubMed ID
nsv906823 CNV Gain 21882294
nsv524364 CNV Loss 19592680
nsv528905 CNV Loss 19592680
esv2714666 CNV Deletion 23290073
dgv503e199 CNV Deletion 23128226
esv2675759 CNV Deletion 23128226
dgv895e1 CNV Complex 17122850
esv33157 CNV Loss 17666407
nsv509630 CNV Insertion 20534489
nsv1853 CNV Loss 18451855
esv25670 CNV Gain+Loss 19812545

Relevant External Links for WWP2 Gene

HapMap Linkage Disequilibrium report
WWP2
Human Gene Mutation Database (HGMD)
WWP2

Disorders for WWP2 Gene

(1) MalaCards Diseases for WWP2 Gene

Search for WWP2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for WWP2 Gene

Relevant External Links for WWP2

Genetic Association Database (GAD)
WWP2
Human Genome Epidemiology (HuGE) Navigator
WWP2
genes like me logo Genes that share disorders with WWP2: view

No data available for UniProtKB/Swiss-Prot for WWP2 Gene

Publications for WWP2 Gene

  1. Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel. (PMID: 12167593) McDonald F.J. … Snyder P.M. (Am. J. Physiol. 2002) 2 3 4 23
  2. Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases. (PMID: 12450395) Galinier R. … Chroboczek J. (Biochemistry 2002) 3 4 23
  3. Identification of novel human WW domain-containing proteins by cloning of ligand targets. (PMID: 9169421) Pirozzi G. … Fowlkes D.M. (J. Biol. Chem. 1997) 2 3 4
  4. N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein. (PMID: 11748237) Harvey K.F. … Kumar S. (J. Biol. Chem. 2002) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for WWP2 Gene

Sources for WWP2 Gene

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