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WWP2 Gene

protein-coding   GIFtS: 65
GCID: GC16P069796

WW Domain Containing E3 Ubiquitin Protein Ligase 2

  See WWP2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WW Domain Containing E3 Ubiquitin Protein Ligase 21 2     EC 6.3.2.-3
AIP22 3     Atrophin-1-Interacting Protein 23
WWp2-like2     WW Domain-Containing Protein 23
Atrophin-1 Interacting Protein 22     EC 6.3.28
NEDD4-Like E3 Ubiquitin-Protein Ligase WWP22     

External Ids:    HGNC: 168041   Entrez Gene: 110602   Ensembl: ENSG000001983737   OMIM: 6023085   UniProtKB: O003083   

Export aliases for WWP2 gene to outside databases

Previous GC identifers: GC16P060490 GC16P070230 GC16P069545 GC16P069586 GC16P069572 GC16P068353 GC16P055674


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WWP2 Gene:
This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein
ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including
chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the
tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed
for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10. (provided by RefSeq,
Jul 2012)

GeneCards Summary for WWP2 Gene:
WWP2 (WW domain containing E3 ubiquitin protein ligase 2) is a protein-coding gene. Diseases associated with WWP2 include campomelic dysplasia. GO annotations related to this gene include RNA polymerase II transcription factor binding and transcription factor binding. An important paralog of this gene is NEDD4L.

UniProtKB/Swiss-Prot: WWP2_HUMAN, O00308
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form
of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by
'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the
ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal
degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the
ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal
degradation

Gene Wiki entry for WWP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WWP2 gene promoter:
         AP-1   ATF-2   c-Jun   ITF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for WWP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WWP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

WWP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WWP2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P069796:  view genomic region     (about GC identifiers)

Start:
69,796,209 bp from pter      End:
69,975,644 bp from pter
Size:
179,436 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: WWP2_HUMAN, O00308 (See protein sequence)
Recommended Name: NEDD4-like E3 ubiquitin-protein ligase WWP2  
Size: 870 amino acids; 98912 Da
Subunit: Interacts with POU5F1, RBP1, EGR2 and SLC11A2 (By similarity). Interacts with SCNN1A, SCNN1B, SCNN1G,
WBP1, WBP2, ATN1 and adenovirus type 2 PIII. Interacts with ERBB4, NDFIP1 AND NDFIP2
Developmental stage: Highly expressed in undifferentiated embryonic stem cells and expression is reduced after
embryoid body (EB) formation. Not detectable at day 13 of EB formation; low levels are again detected at day 18
of EB formation
Miscellaneous: A cysteine residue is required for ubiquitin-thioester formation
Sequence caution: Sequence=BAC86528.1; Type=Frameshift; Positions=757;
Secondary accessions: A6NEP1 B2R706 B4DTL5 F5H213 H3BRF3 I3RSG8 Q6ZTQ5 Q96CZ2 Q9BWN6
Alternative splicing: 3 isoforms:  O00308-1   O00308-2   O00308-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WWP2: NX_O00308

Explore proteomics data for WWP2 at MOPED

Post-translational modifications: 

  • Autoubiquitinated. Ubiquitinated by the SCF(FBXL15) complex, leading to its degradation by the proteasome1
  • Ubiquitination2 at Lys632
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for WWP2 (O00308) (see all 15)
     LQINPAS  PLPPGWE  TQWEDPR  RLLQFVTG 


    See WWP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001257382.1  NP_001257383.1  NP_001257384.1  NP_008945.2  NP_955456.1  

    ENSEMBL proteins: 
     ENSP00000352069   ENSP00000456451   ENSP00000456582   ENSP00000455347   ENSP00000455311  
     ENSP00000456216   ENSP00000396871   ENSP00000348283   ENSP00000445616  

    WWP2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Proteins for WWP2
    OriGene Protein Over-expression Lysate for WWP2
    OriGene MassSpec for WWP2
    OriGene Custom Protein Services for WWP2
    GenScript Custom Purified and Recombinant Proteins Services for WWP2
    Novus Biologicals WWP2 Proteins
    Novus Biologicals WWP2 Lysates
    Sino Biological Recombinant Protein for WWP2
    Sino Biological Cell Lysate for WWP2
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WWP2

     
    Search eBioscience for Proteins for WWP2 

     
    antibodies-online proteins for WWP2 (5 products) 

     
    antibodies-online peptides for WWP2

    WWP2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals WWP2 Antibodies
    Abcam antibodies for WWP2
    Cloud-Clone Corp. Antibodies for WWP2
    Search ThermoFisher Antibodies for WWP2
    antibodies-online antibodies for WWP2 (25 products) 

    WWP2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for WWP2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for WWP2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for WWP2
    Cloud-Clone Corp. CLIAs for WWP2
    Search eBioscience for ELISAs for WWP2 
    antibodies-online kits for WWP2 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR024928 E3_ub_ligase_SMURF1
     IPR000569 HECT
     IPR001202 WW_dom
     IPR000008 C2_dom

    Graphical View of Domain Structure for InterPro Entry O00308

    ProtoNet protein and cluster: O00308

    3 Blocks protein domains:
    IPB000008 C2 domain
    IPB000569 HECT domain (Ubiquitin-protein ligase)
    IPB002349 WW domain signature


    UniProtKB/Swiss-Prot: WWP2_HUMAN, O00308
    Domain: The C2 domain is involved in autoinhibition of the catalytic activity by interacting with the HECT domain
    (By similarity)
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain
    Similarity: Contains 4 WW domains


    Find genes that share domains with WWP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WWP2_HUMAN, O00308
    Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form
    of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by
    'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the
    ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal
    degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the
    ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal
    degradation
    Enzyme regulation: Activated by NDFIP1- and NDFIP2-binding

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001085RNA polymerase II transcription factor binding ISS15047715
    GO:0004842ubiquitin-protein ligase activity IMP18776082
    GO:0005515protein binding IPI18729074
    GO:0008134transcription factor binding IPI19651900
         
    Find genes that share ontologies with WWP2           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for WWP2:
     Decreased viability  Elongated cells  G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for WWP2

    miRNA
    Products:
        
    miRTarBase miRNAs that target WWP2:
    hsa-mir-23b-3p (MIRT046361), hsa-mir-615-3p (MIRT040274), hsa-mir-26a-5p (MIRT050195), hsa-let-7a-5p (MIRT052448)

    Block miRNA regulation of human, mouse, rat WWP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WWP2 (see all 34):
    hsa-miR-3678-3p hsa-miR-25 hsa-miR-219-5p hsa-miR-508-3p hsa-miR-4267 hsa-miR-9 hsa-miR-637 hsa-miR-1243
    SwitchGear 3'UTR luciferase reporter plasmidWWP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for WWP2
    Predesigned siRNA for gene silencing in human, mouse, rat WWP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for WWP2

    Clone
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    OriGene clones in human, mouse for WWP2 (see all 18)
    OriGene ORF clones in mouse, rat for WWP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): WWP2 (NM_007014)
    Sino Biological Human cDNA Clone for WWP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WWP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WWP2
    Addgene plasmids for WWP2 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for WWP2
    Browse ESI BIO Cell Lines and PureStem Progenitors for WWP2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WWP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WWP2_HUMAN, O00308: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion2
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex TAS9647693
    GO:0005634nucleus IDA19274063
    GO:0005737cytoplasm ISS15047715

    Find genes that share ontologies with WWP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WWP2 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Ubiquitin mediated proteolysis0.35
    2Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis
    3SMAD Signaling Network
    SMAD Signaling Network
    4CFTR dependent regulation of ion channels in Airway Epithelium norm and CF
    CFTR dependent regulation of ion channels in Airway Epithelium norm and CF


    Find genes that share SuperPaths with WWP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for WWP2
        SMAD Signaling Network
    Ubiquitin-Proteasome Dependent Proteolysis

    1 GeneGo (Thomson Reuters) Pathway for WWP2
        CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)



    1 Kegg Pathway  (Kegg details for WWP2):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: WWP2_HUMAN, O00308
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WWP2
    Interactions:

        GeneGlobe Interaction Network for WWP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WWP2 (O003081, 2, 3 ENSP000003482834) via UniProtKB, MINT, STRING, and/or I2D (see all 152)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADARB1P785631, 2, 3, ENSP000003539204EBI-743923,EBI-2967304 MINT-8299234 MINT-8299276 MINT-8299218 MINT-8299255 MINT-8299302 I2D: score=1 STRING: ENSP00000353920
    ENSG00000206454Q018601, 3EBI-743923,EBI-475687 I2D: score=1 
    ENSG00000229094Q018601, 3EBI-743923,EBI-475687 I2D: score=1 
    ENSG00000230336Q018601, 3EBI-743923,EBI-475687 I2D: score=1 
    ENSG00000233911Q018601, 3EBI-743923,EBI-475687 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS15047715
    GO:0006464cellular protein modification process TAS9169421
    GO:0010629negative regulation of gene expression IMP18776082
    GO:0016567protein ubiquitination IDA18776082
    GO:0019048modulation by virus of host morphology or physiology ----

    Find genes that share ontologies with WWP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WWP2

    4 HMDB Compounds for WWP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WWP2 gene (5 alternative transcripts): 
    NM_001270453.1  NM_001270454.1  NM_001270455.1  NM_007014.4  NM_199424.2  

    Unigene Cluster for WWP2:

    WW domain containing E3 ubiquitin protein ligase 2
    Hs.408458  [show with all ESTs]
    Unigene Representative Sequence: NM_007014
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000359154(uc002exv.1) ENST00000561780 ENST00000569620 ENST00000568845
    ENST00000563659 ENST00000569658 ENST00000569174(uc002ext.3) ENST00000544162
    ENST00000567986 ENST00000563618 ENST00000570104 ENST00000569297 ENST00000567579
    ENST00000566463 ENST00000568684(uc002exw.1) ENST00000568185 ENST00000568818
    ENST00000567161
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate WWP2 (see all 34):
    hsa-miR-3678-3p hsa-miR-25 hsa-miR-219-5p hsa-miR-508-3p hsa-miR-4267 hsa-miR-9 hsa-miR-637 hsa-miR-1243
    SwitchGear 3'UTR luciferase reporter plasmidWWP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat WWP2
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): WWP2 (NM_007014)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WWP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WWP2
    Addgene plasmids for WWP2 
    Primer
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    OriGene qPCR primer pairs and template standards for WWP2
    OriGene qSTAR qPCR primer pairs in human, mouse for WWP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WWP2
      QuantiTect SYBR Green Assays in human, mouse, rat WWP2
      QuantiFast Probe-based Assays in human, mouse, rat WWP2

    Additional mRNA sequence: 

    AJ001982.1 AK126332.1 AK295070.1 AK295701.1 AK300266.1 AK312792.1 AK316097.1 BC000108.2 
    BC013645.1 BC064531.1 U96114.1 

    14 DOTS entries:

    DT.99940438  DT.410681  DT.101954997  DT.102845576  DT.100795826  DT.100795824  DT.420430  DT.91707635 
    DT.91752262  DT.91884610  DT.100742767  DT.100795828  DT.100795829  DT.75137354 

    Selected AceView cDNA sequences (see all 209):

    BE314296 CR599492 BI769584 BM818120 AL583086 BI195805 CB054385 AK126332 
    CD106378 AJ705788 NM_007014 BQ919036 BQ063835 AI635734 NM_199424 BM700600 
    BX471495 BU737819 BU188599 BQ215659 BU737757 AA719649 BM800835 AI418041 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for WWP2 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a ·
    SP1:              -           -                 -                 -                       -     -           -           -                                   -   
    SP2:                          -                 -                 -                       -     -           -           -                                   -   
    SP3:                          -                 -                 -                                                                                             
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b
    SP1:                                      -     -                                             
    SP2:                                      -     -                                             
    SP3:                                                                                          
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for WWP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WWP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTGGTCAC
    WWP2 Expression
    About this image


    WWP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 9 entries
             Mandibular Condyle
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Meckel's Cartilage
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Chondrocytes Tracheal Cartilage
             Tracheal Cartilage
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Pelvic Girdle
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    WWP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WWP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.408458

    UniProtKB/Swiss-Prot: WWP2_HUMAN, O00308
    Tissue specificity: Detected in heart, throughout the brain, placenta, lung, liver, muscle, kidney and pancreas.
    Also detected in spleen and peripheral blood leukocytes

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for WWP2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wwp21 , 5 WW domain containing E3 ubiquitin protein ligase 21, 5 89.85(n)1
    95.98(a)1
      8 (54.15 cM)5
    668941  NM_025830.31  NP_080106.11 
     1074363985 
    chicken
    (Gallus gallus)
    Aves WWP21 WW domain containing E3 ubiquitin protein ligase 2 78.6(n)
    84.81(a)
      415868  NM_001039260.1  NP_001034349.1 
    lizard
    (Anolis carolinensis)
    Reptilia WWP26
    WW domain containing E3 ubiquitin protein ligase 2...
    81(a)
    1 ↔ 1
    GL343643.1(172190-214414)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia wwp21 WW domain containing E3 ubiquitin protein ligase 2 73.99(n)
    84.98(a)
      100038252  NM_001097372.1  NP_001090841.1 
    zebrafish
    (Danio rerio)
    Actinopterygii idibd11212 idibd1121 78.63(n)   58020  57049991 
    fruit fly
    (Drosophila melanogaster)
    Insecta Su(dx)3 N receptor signaling pathway
    ubiquitin-protein more
    67(a)   2 22C1   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y65B4BR.4a3   -- 64(a)
    (best of 2)
      I(537141-541634)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RSP56
    E3 ubiquitin ligase of the NEDD4 family; involved ...
    39(a)
    1 → many
    V(410189-412618) YER125W


    ENSEMBL Gene Tree for WWP2 (if available)
    TreeFam Gene Tree for WWP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WWP2 gene
    NEDD4L2  HECW22  AREL12  UBR52  SMURF22  HECW12  SMURF12  HUWE12  
    NEDD42  WWP12  ITCH2  
    11 SIMAP similar genes for WWP2 using alignment to 4 protein entries:     WWP2_HUMAN (see all proteins):
    WWP1    ITCH    NEDD4    HUWE1    SMURF1    SMURF2
    HECW1    NEDD4L    NEDL1    HECW2    PIN1P1

    Find genes that share paralogs with WWP2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for WWP2
    PGOHUM00000238507


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WWP2 (see all 3886)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1390579901,2
    C--69794318(+) CCTCCA/GCCTCC 3 -- us2k10--------
    rs711511331,2
    C--69794417(+) TTTTT-/T/TTTT
            
    GTAGT
    3 -- us2k11NA 2
    rs1498989271,2
    --69794435(+) GAGATA/GGGGTT 3 -- us2k10--------
    rs1925357771,2
    --69794457(+) GCCAAA/GTGGGT 3 -- us2k10--------
    rs1439632591,2
    --69794605(+) ATAACA/GGATTA 3 -- us2k10--------
    rs1849596901,2
    --69794737(+) AGGCCA/GGGCGC 3 -- us2k10--------
    rs1890271071,2
    --69794937(+) TTGAAC/TCTGGG 3 -- us2k10--------
    rs1398996991,2
    --69794938(+) TGAACC/TTGGGA 3 -- us2k10--------
    rs1807978681,2
    --69794992(+) CCTGGA/GCTACA 3 -- us2k10--------
    rs1431856671,2
    C--69795024(+) CAAGC-/AAAT  
            
    AAATA
    3 -- us2k10--------

    HapMap Linkage Disequilibrium report for WWP2 (69796209 - 69975644 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for WWP2 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714666CNV Deletion23290073
    dgv503e199CNV Deletion23128226
    esv2675759CNV Deletion23128226
    nsv509630CNV Insertion20534489
    nsv524364CNV Loss19592680
    nsv1853CNV Loss18451855
    esv33157CNV Loss17666407
    nsv528905CNV Loss19592680
    nsv906823CNV Gain21882294
    esv25670CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602308    OMIM disorders: --

    1 disease for WWP2:    
    About MalaCards
    campomelic dysplasia

    1 disease from the University of Copenhagen DISEASES database for WWP2:
    Campomelic dysplasia

    Find genes that share disorders with WWP2           About GenesLikeMe

    Genetic Association Database (GAD): WWP2
    Human Genome Epidemiology (HuGE) Navigator: WWP2 (1 document)

    Export disorders for WWP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WWP2 gene, integrated from 10 sources (see all 65):
    (articles sorted by number of sources associating them with WWP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel. (PubMed id 12167593)1, 2, 3, 9 McDonald F.J....Snyder P.M. (Am. J. Physiol. 2002)
    2. Identification of novel human WW domain-containing proteins by cloning of ligand targets. (PubMed id 9169421)1, 2, 3 Pirozzi G.... Fowlkes D.M. (J. Biol. Chem. 1997)
    3. Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases. (PubMed id 12450395)1, 2, 9 Galinier R.... Chroboczek J. (Biochemistry 2002)
    4. SCF(FBXL15) regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1. (PubMed id 21572392)1, 2 Cui Y.... Zhang L. (EMBO J. 2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins. (PubMed id 19343052)1, 2 Mund T. and Pelham H.R. (EMBO Rep. 2009)
    7. The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T- cell death by catalyzing EGR2 ubiquitination. (PubMed id 19651900)1, 2 Chen A.... Fang D. (Mol. Cell. Biol. 2009)
    8. WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells. (PubMed id 19274063)1, 2 Xu H.... Jin Y. (Cell Res. 2009)
    9. Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain. (PubMed id 17719543)1, 2 Wiesner S.... Forman-Kay J.D. (Cell 2007)
    10. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11060 HGNC: 16804 AceView: WWP2 Ensembl:ENSG00000198373 euGenes: HUgn11060
    ECgene: WWP2 Kegg: 11060 H-InvDB: WWP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WWP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WWP2 gene:
    Search GeneIP for patents involving WWP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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