Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WWP2 Gene

protein-coding   GIFtS: 64
GCID: GC16P069796

WW Domain Containing E3 Ubiquitin Protein Ligase 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
WW Domain Containing E3 Ubiquitin Protein Ligase 21 2     EC 6.3.2.-3
AIP22 3     Atrophin-1-Interacting Protein 23
WWp2-like2     WW Domain-Containing Protein 23
Atrophin-1 Interacting Protein 22     EC 6.3.28
NEDD4-Like E3 Ubiquitin-Protein Ligase WWP22     

External Ids:    HGNC: 168041   Entrez Gene: 110602   Ensembl: ENSG000001983737   OMIM: 6023085   UniProtKB: O003083   

Export aliases for WWP2 gene to outside databases

Previous GC identifers: GC16P060490 GC16P070230 GC16P069545 GC16P069586 GC16P069572 GC16P068353 GC16P055674


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WWP2 Gene:
This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein
ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including
chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the
tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed
for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10. (provided by RefSeq,
Jul 2012)

GeneCards Summary for WWP2 Gene: 
WWP2 (WW domain containing E3 ubiquitin protein ligase 2) is a protein-coding gene. Diseases associated with WWP2 include campomelic dysplasia, and pick's disease, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation. GO annotations related to this gene include RNA polymerase II transcription factor binding and transcription factor binding. An important paralog of this gene is HERC1.

UniProtKB/Swiss-Prot: WWP2_HUMAN, O00308
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form
of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by
'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the
ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal
degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the
ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal
degradation

Gene Wiki entry for WWP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WWP2 gene promoter:
         AP-1   ATF-2   c-Jun   ITF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for WWP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WWP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

WWP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WWP2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P069796:  view genomic region     (about GC identifiers)

Start:
69,796,209 bp from pter      End:
69,975,644 bp from pter
Size:
179,436 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WWP2_HUMAN, O00308 (See protein sequence)
Recommended Name: NEDD4-like E3 ubiquitin-protein ligase WWP2  
Size: 870 amino acids; 98912 Da
Subunit: Interacts with POU5F1, RBP1, EGR2 and SLC11A2 (By similarity). Interacts with SCNN1A, SCNN1B, SCNN1G,
WBP1, WBP2, ATN1 and adenovirus type 2 PIII. Interacts with ERBB4, NDFIP1 AND NDFIP2
Subcellular location: Nucleus
Developmental stage: Highly expressed in undifferentiated embryonic stem cells and expression is reduced after
embryoid body (EB) formation. Not detectable at day 13 of EB formation; low levels are again detected at day 18
of EB formation
Miscellaneous: A cysteine residue is required for ubiquitin-thioester formation
Sequence caution: Sequence=BAC86528.1; Type=Frameshift; Positions=757;
Secondary accessions: A6NEP1 B2R706 B4DTL5 F5H213 H3BRF3 I3RSG8 Q6ZTQ5 Q96CZ2 Q9BWN6
Alternative splicing: 3 isoforms:  O00308-1   O00308-2   O00308-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WWP2: NX_O00308

Explore proteomics data for WWP2 at MOPED 

Post-translational modifications:

  • UniProtKB: Autoubiquitinated. Ubiquitinated by the SCF(FBXL15) complex, leading to its degradation by the proteasome
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00308

  • 4/15 DME Specific Peptides for WWP2 (O00308) (see all 15)
     LQINPAS  PLPPGWE  TQWEDPR  RLLQFVTG 

    WWP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WWP2 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001257382.1  NP_001257383.1  NP_001257384.1  NP_008945.2  NP_955456.1  

    ENSEMBL proteins: 
     ENSP00000352069   ENSP00000456451   ENSP00000456582   ENSP00000455347   ENSP00000455311  
     ENSP00000456216   ENSP00000396871   ENSP00000348283   ENSP00000445616  

    Human Recombinant Protein Products for WWP2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for WWP2
    OriGene Protein Over-expression Lysate for WWP2
    OriGene MassSpec for WWP2 
    OriGene Custom Protein Services for WWP2
    GenScript Custom Purified and Recombinant Proteins Services for WWP2
    Novus Biologicals WWP2 Proteins
    Novus Biologicals WWP2 Lysates
    Sino Biological Recombinant Protein for WWP2
    Sino Biological Cell Lysate for WWP2 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WWP2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex TAS9647693
    GO:0005634nucleus IDA19274063
    GO:0005737cytoplasm ISS15047715

    WWP2 for ontologies           About GeneDecksing



    WWP2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for WWP2
    GenScript Custom Superior Antibodies Services for WWP2
    Novus Biologicals WWP2 Antibodies
    Abcam antibodies for WWP2
    Cloud-Clone Corp. Antibodies for WWP2 
    Search ThermoFisher Antibodies for WWP2
    LSBio Antibodies in human, mouse, rat for WWP2 

    Assay Products for WWP2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for WWP2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for WWP2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for WWP2 
    Cloud-Clone Corp. CLIAs for WWP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR024928 E3_ub_ligase_SMURF1
     IPR001202 WW_dom
     IPR000569 HECT
     IPR000008 C2_Ca-dep

    Graphical View of Domain Structure for InterPro Entry O00308

    ProtoNet protein and cluster: O00308

    3 Blocks protein domains:
    IPB000008 C2 domain
    IPB000569 HECT domain (Ubiquitin-protein ligase)
    IPB002349 WW domain signature


    UniProtKB/Swiss-Prot: WWP2_HUMAN, O00308
    Domain: The C2 domain is involved in autoinhibition of the catalytic activity by interacting with the HECT domain
    (By similarity)
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain
    Similarity: Contains 4 WW domains


    WWP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WWP2_HUMAN, O00308
    Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form
    of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by
    'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the
    ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal
    degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the
    ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal
    degradation
    Enzyme regulation: Activated by NDFIP1- and NDFIP2-binding

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001085RNA polymerase II transcription factor binding ISS15047715
    GO:0004842ubiquitin-protein ligase activity IMP18776082
    GO:0005515protein binding IPI18729074
    GO:0008134transcription factor binding IPI19651900
         
    WWP2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for WWP2:
     Decreased viability  Elongated cells  G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for WWP2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for WWP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WWP2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WWP2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WWP2
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate WWP2 (see all 34):
    hsa-miR-3678-3p hsa-miR-25 hsa-miR-219-5p hsa-miR-508-3p hsa-miR-4267 hsa-miR-9 hsa-miR-637 hsa-miR-1243
    SwitchGear 3'UTR luciferase reporter plasmidWWP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for WWP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WWP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for WWP2
    Sirion Biotech Customized adenovirus for overexpression of WWP2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for WWP2 (see all 20)
    OriGene ORF clones in mouse, rat for WWP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): WWP2 (NM_007014)
    Sino Biological Human cDNA Clone for WWP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WWP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WWP2
    Sirion Biotech Customized lentivirus for stable overexpression of WWP2 
                         Customized lentivirus expression plasmids for stable overexpression of WWP2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for WWP2
    Search LifeMap BioReagents cell lines for WWP2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WWP2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for WWP2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Ubiquitin mediated proteolysis0.36
    2Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis
    3SMAD Signaling Network
    SMAD Signaling Network
    4CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)
    CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for WWP2
        SMAD Signaling Network
    Ubiquitin-Proteasome Dependent Proteolysis

    1 GeneGo (Thomson Reuters) Pathway for WWP2
        CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)



    1         Kegg Pathway  (Kegg details for WWP2):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: WWP2_HUMAN, O00308
    Pathway: Protein modification; protein ubiquitination


    WWP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WWP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/71 Interacting proteins for WWP2 (O003081, 2, 3 ENSP000003482834) via UniProtKB, MINT, STRING, and/or I2D (see all 71)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CPSF6Q166302, 3, ENSP000003917744MINT-67985 I2D: score=5 STRING: ENSP00000391774
    SMAD2Q157961, 3, ENSP000002621604EBI-743923,EBI-1040141 I2D: score=5 STRING: ENSP00000262160
    SMAD3P840221, 3, ENSP000003329734EBI-743923,EBI-347161 I2D: score=4 STRING: ENSP00000332973
    SMAD7O151051, 3, ENSP000002621584EBI-743923,EBI-3861591 I2D: score=2 STRING: ENSP00000262158
    RNF11Q9Y3C52, 3MINT-60864 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS15047715
    GO:0006464cellular protein modification process TAS9169421
    GO:0010629negative regulation of gene expression IMP18776082
    GO:0016567protein ubiquitination IDA18776082
    GO:0019048modulation by virus of host morphology or physiology IEA--

    WWP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WWP2

    4 HMDB Compounds for WWP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Search CenterWatch for drugs/clinical trials and news about WWP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WWP2 gene (5 alternative transcripts): 
    NM_001270453.1  NM_001270454.1  NM_001270455.1  NM_007014.4  NM_199424.2  

    Unigene Cluster for WWP2:

    WW domain containing E3 ubiquitin protein ligase 2
    Hs.408458  [show with all ESTs]
    Unigene Representative Sequence: NM_007014
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000359154(uc002exv.1) ENST00000561780 ENST00000569620 ENST00000568845
    ENST00000563659 ENST00000569658 ENST00000569174(uc002ext.3) ENST00000544162
    ENST00000567986 ENST00000563618 ENST00000570104 ENST00000569297 ENST00000567579
    ENST00000566463 ENST00000568684(uc002exw.1) ENST00000568185 ENST00000568818
    ENST00000567161
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WWP2
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate WWP2 (see all 34):
    hsa-miR-3678-3p hsa-miR-25 hsa-miR-219-5p hsa-miR-508-3p hsa-miR-4267 hsa-miR-9 hsa-miR-637 hsa-miR-1243
    SwitchGear 3'UTR luciferase reporter plasmidWWP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for WWP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WWP2
    Clone
    Products:
         
    OriGene clones in human, mouse for WWP2 (see all 20)
    OriGene ORF clones in mouse, rat for WWP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): WWP2 (NM_007014)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WWP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WWP2
    Sirion Biotech Customized lentivirus for stable overexpression of WWP2 
                         Customized lentivirus expression plasmids for stable overexpression of WWP2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for WWP2
    OriGene qSTAR qPCR primer pairs in human, mouse for WWP2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WWP2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WWP2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WWP2

    Additional mRNA sequence: 

    AJ001982.1 AK126332.1 AK295070.1 AK295701.1 AK300266.1 AK312792.1 AK316097.1 BC000108.2 
    BC013645.1 BC064531.1 U96114.1 

    14 DOTS entries:

    DT.99940438  DT.410681  DT.101954997  DT.102845576  DT.100795826  DT.100795824  DT.420430  DT.91707635 
    DT.91752262  DT.91884610  DT.100742767  DT.100795828  DT.100795829  DT.75137354 

    24/209 AceView cDNA sequences (see all 209):

    CD623555 BE314296 CR599492 BI769584 BM818120 AL583086 BI195805 CB054385 
    AK126332 CD106378 AJ705788 NM_007014 BQ919036 BQ063835 AI635734 NM_199424 
    BM700600 BX471495 BU737819 BU188599 BQ215659 BU737757 AA719649 BM800835 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for WWP2 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a ·
    SP1:              -           -                 -                 -                       -     -           -           -                                   -   
    SP2:                          -                 -                 -                       -     -           -           -                                   -   
    SP3:                          -                 -                 -                                                                                             
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b
    SP1:                                      -     -                                             
    SP2:                                      -     -                                             
    SP3:                                                                                          
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for WWP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WWP2 expression in normal human tissues (normalized intensities)      WWP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTGGTCAC
    WWP2 Expression
    About this image


    WWP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 15 entries
             Mandibular Condyle
             skeleton/pectoral girdle and thoracic body wall/sternum   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 7 entries
             Meckel's Cartilage
             fetal cartilage   
     
     Lung (Respiratory System)    fully expand to see all 5 entries
             Chondrocytes Tracheal Cartilage
             Tracheal Cartilage
             visceral organ/lung/left lung   
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 4 entries
             skeleton/cranium/chondrocranium   
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             neutrophils   

    See WWP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WWP2

    SOURCE GeneReport for Unigene cluster: Hs.408458

    UniProtKB/Swiss-Prot: WWP2_HUMAN, O00308
    Tissue specificity: Detected in heart, throughout the brain, placenta, lung, liver, muscle, kidney and pancreas.
    Also detected in spleen and peripheral blood leukocytes

        SABiosciences Custom PCR Arrays for WWP2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for WWP2
    OriGene qSTAR qPCR primer pairs in human, mouse for WWP2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WWP2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WWP2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WWP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WWP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for WWP2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wwp21 , 5 WW domain containing E3 ubiquitin protein ligase 21, 5 89.85(n)1
    95.98(a)1
      8 (54.15 cM)5
    668941  NM_025830.31  NP_080106.11 
     1074363985 
    chicken
    (Gallus gallus)
    Aves WWP21 WW domain containing E3 ubiquitin protein ligase 2 78.52(n)
    84.81(a)
      415868  NM_001039260.1  NP_001034349.1 
    lizard
    (Anolis carolinensis)
    Reptilia WWP26
    E3 ubiquitin-protein ligase
    83(a)
    1 ↔ 1
    GL343643.1(172190-214414)
    zebrafish
    (Danio rerio)
    Actinopterygii idibd11212 idibd1121 78.63(n)   58020  57049991 
    fruit fly
    (Drosophila melanogaster)
    Insecta Su(dx)3 N receptor signaling pathway
    ubiquitin-protein more
    67(a)   2 22C1   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y65B4BR.4a3   -- 64(a)
    (best of 2)
      I(537141-541634)   --


    ENSEMBL Gene Tree for WWP2 (if available)
    TreeFam Gene Tree for WWP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WWP2 gene
    HERC12  NEDD4L2  HECW22  HERC22  HECTD32  HECW12  SMURF22  SMURF12  
    HUWE12  NEDD42  WWP12  ITCH2  
    11 SIMAP similar genes for WWP2 using alignment to 4 protein entries:     WWP2_HUMAN (see all proteins):
    WWP1    ITCH    NEDD4    HUWE1    SMURF1    SMURF2
    HECW1    NEDD4L    NEDL1    HECW2    PIN1P1

    WWP2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for WWP2
    PGOHUM00000238507


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3886 SNPs in WWP2 are shown (see all 3886)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1390579901,2
    C--69794318(+) CCTCCA/GCCTCC 3 -- us2k10--------
    rs711511331,2
    C--69794417(+) TTTTT-/T/TTTT
            
    GTAGT
    3 -- us2k11NA 2
    rs1498989271,2
    --69794435(+) GAGATA/GGGGTT 3 -- us2k10--------
    rs1925357771,2
    --69794457(+) GCCAAA/GTGGGT 3 -- us2k10--------
    rs1439632591,2
    --69794605(+) ATAACA/GGATTA 3 -- us2k10--------
    rs1849596901,2
    --69794737(+) AGGCCA/GGGCGC 3 -- us2k10--------
    rs1890271071,2
    --69794937(+) TTGAAC/TCTGGG 3 -- us2k10--------
    rs1398996991,2
    --69794938(+) TGAACC/TTGGGA 3 -- us2k10--------
    rs1807978681,2
    --69794992(+) CCTGGA/GCTACA 3 -- us2k10--------
    rs1431856671,2
    C--69795024(+) CAAGC-/AAAT  
            
    AAATA
    3 -- us2k10--------

    HapMap Linkage Disequilibrium report for WWP2 (69796209 - 69975644 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for WWP2 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2714666CNV Deletion23290073
    dgv503e199CNV Deletion23128226
    esv2675759CNV Deletion23128226
    nsv509630CNV Insertion20534489
    nsv524364CNV Loss19592680
    nsv1853CNV Loss18451855
    esv33157CNV Loss17666407
    nsv528905CNV Loss19592680
    nsv906823CNV Gain21882294
    esv25670CNV Gain+Loss19812545

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing WWP2
    DNA2.0 Custom Variant and Variant Library Synthesis for WWP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602308    OMIM disorders: --

    3 diseases for WWP2:    About MalaCards
    campomelic dysplasia    pick's disease    gout

    1 disease from the University of Copenhagen DISEASES database for WWP2:
    Campomelic dysplasia

    WWP2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): WWP2
    Human Genome Epidemiology (HuGE) Navigator: WWP2 (1 document)

    Export disorders for WWP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WWP2 gene, integrated from 9 sources (see all 61):
    (articles sorted by number of sources associating them with WWP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel. (PubMed id 12167593)1, 2, 3, 9 McDonald F.J....Snyder P.M. (2002)
    2. Identification of novel human WW domain-containing proteins by cloning of ligand targets. (PubMed id 9169421)1, 2, 3 Pirozzi G.... Fowlkes D.M. (1997)
    3. Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases. (PubMed id 12450395)1, 2, 9 Galinier R.... Chroboczek J. (2002)
    4. SCF(FBXL15) regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1. (PubMed id 21572392)1, 2 Cui Y.... Zhang L. (2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. WWP2 promotes degradation of transcription factor OCT 4 in human embryonic stem cells. (PubMed id 19274063)1, 2 Xu H....Jin Y. (2009)
    7. Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins. (PubMed id 19343052)1, 2 Mund T. and Pelham H.R. (2009)
    8. The HECT-type E3 ubiquitin ligase AIP2 inhibits activ ation-induced T-cell death by catalyzing EGR2 ubiquitination. (PubMed id 19651900)1, 2 Chen A....Fang D. (2009)
    9. Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain. (PubMed id 17719543)1, 2 Wiesner S.... Forman-Kay J.D. (2007)
    10. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11060 HGNC: 16804 AceView: WWP2 Ensembl:ENSG00000198373 euGenes: HUgn11060
    ECgene: WWP2 Kegg: 11060 H-InvDB: WWP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WWP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WWP2 gene:
    Search GeneIP for patents involving WWP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for WWP2  
     OriGene qPCR primer pairs and template standards for WWP2   OriGene Protein Over-expression Lysate for WWP2  
     OriGene MassSpec something-or-other for WWP2   OriGene clones in human, mouse for WWP2  
     OriGene qSTAR qPCR primer pairs in human, mouse for WWP2   OriGene Purified Protein for WWP2  
     OriGene ORF clones in mouse, rat for WWP2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for WWP2   OriGene Custom Protein Services for WWP2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WWP2
     QIAGEN SeqTarget long-range PCR primers for resequencing WWP2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WWP2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WWP2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WWP2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WWP2
     GenScript Custom Purified and Recombinant Proteins Services for WWP2 GenScript cDNA clones with any tag delivered in your preferred vector for WWP2
     GenScript Custom Assay Services for WWP2 GenScript Custom Superior Antibodies Services for WWP2
     GenScript Custom overexpressing Cell Line Services for WWP2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in WWP2 promoter
     Search Chromatin IP Primers for WWP2
     RT2 qPCR Primer Assay in human, mouse, rat WWP2
     GNC Network for WWP2
     SABiosciences PCR Arrays including human, mouse, rat WWP2
     Search Tocris compounds for WWP2
     Proteins and Antibodies for WWP2
     Cell Lysates for WWP2
     cDNA Clones for WWP2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     WWP2 antibodies
     WWP2 proteins
     WWP2 lysates
     Antibodies for WWP2
     See all of Abcam's Antibodies, Kits and Proteins for WWP2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for WWP2
     Antibodies for WWP2
     ELISAs for WWP2
     CLIAs for WWP2
     Search LifeMap BioReagents cell lines for WWP2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WWP2
     SwitchGear 3'UTR luciferase reporter plasmids for WWP2
     Browse SwitchGear Promoter luciferase reporter plasmids for WWP2
     Search ThermoFisher Antibodies for WWP2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WWP2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for WWP2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for WWP2
    Customized:
     lentivirus for stable overexpression of WWP2
     lentivirus expression plasmids for stable overexpression of WWP2
     adenovirus for overexpression of WWP2
     LSBio Antibodies in human, mouse, rat for WWP2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      WWP2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4