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Aliases for WWP1 Gene

Aliases for WWP1 Gene

  • WW Domain Containing E3 Ubiquitin Protein Ligase 1 2 3
  • TGIF-Interacting Ubiquitin Ligase 1 3 4
  • Atrophin-1-Interacting Protein 5 3 4
  • WW Domain-Containing Protein 1 3 4
  • Tiul1 3 4
  • AIP5 3 4
  • Nedd-4-Like Ubiquitin-Protein Ligase 3
  • Atrophin-1 Interacting Protein 5 3
  • EC 6.3.2.- 4
  • EC 6.3.2 63
  • HSDRP1 3

External Ids for WWP1 Gene

Previous GeneCards Identifiers for WWP1 Gene

  • GC08P085970
  • GC08P087113
  • GC08P087337
  • GC08P087311
  • GC08P087424
  • GC08P082564

Summaries for WWP1 Gene

Entrez Gene Summary for WWP1 Gene

  • WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]

GeneCards Summary for WWP1 Gene

WWP1 (WW Domain Containing E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is AREL1.

UniProtKB/Swiss-Prot for WWP1 Gene

  • E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.

Gene Wiki entry for WWP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WWP1 Gene

Genomics for WWP1 Gene

Regulatory Elements for WWP1 Gene

Genomic Location for WWP1 Gene

Chromosome:
8
Start:
86,342,736 bp from pter
End:
86,478,420 bp from pter
Size:
135,685 bases
Orientation:
Plus strand

Genomic View for WWP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WWP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WWP1 Gene

Proteins for WWP1 Gene

  • Protein details for WWP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0M0-WWP1_HUMAN
    Recommended name:
    NEDD4-like E3 ubiquitin-protein ligase WWP1
    Protein Accession:
    Q9H0M0
    Secondary Accessions:
    • O00307
    • Q5YLC1
    • Q96BP4

    Protein attributes for WWP1 Gene

    Size:
    922 amino acids
    Molecular mass:
    105202 Da
    Quaternary structure:
    • Binds KLF2 AND HIVEP3 (By similarity). Binds SCNN1A, SCNN1B, SCNN1G, WBP1, WBP2, DRPLA and adenovirus type 2 PIII. Interacts with RNF11 (By similarity). Interacts with SPG20. Interacts with ERBB4 isoforms JM-B CYT-1 and JM-A CYT-1. Interacts with SMAD1, SMAD2, SMAD3, SMAD5, SMAD6, SMAD7, TGFBR1 AND TGFBR2. Associates with the TGFBR1:TGFBR2 receptor complex in presence of SMAD7. Interacts with SKIL isoform 1. Interacts with TP63 isoform 1 and isoform 2. Interacts with STAMBP and RNF11. Interacts with NDFIP1 and NDFIP2 (Probable); this interaction activates the E3 ubiquitin-protein ligase. Interacts with TGIF.

    Three dimensional structures from OCA and Proteopedia for WWP1 Gene

    Alternative splice isoforms for WWP1 Gene

neXtProt entry for WWP1 Gene

Proteomics data for WWP1 Gene at MOPED

Post-translational modifications for WWP1 Gene

Other Protein References for WWP1 Gene

Domains & Families for WWP1 Gene

Gene Families for WWP1 Gene

Suggested Antigen Peptide Sequences for WWP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0M0

UniProtKB/Swiss-Prot:

WWP1_HUMAN :
  • Contains 1 C2 domain.
Domain:
  • Contains 1 C2 domain.
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
  • Contains 4 WW domains.
genes like me logo Genes that share domains with WWP1: view

Function for WWP1 Gene

Molecular function for WWP1 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by NDFIP1- and NDFIP2-binding
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.

Enzyme Numbers (IUBMB) for WWP1 Gene

Gene Ontology (GO) - Molecular Function for WWP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS 9169421
GO:0005515 protein binding IPI 9647693
GO:0016874 ligase activity IEA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with WWP1: view
genes like me logo Genes that share phenotypes with WWP1: view

Animal Models for WWP1 Gene

MGI Knock Outs for WWP1:

Animal Model Products

miRNA for WWP1 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WWP1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for WWP1 Gene

Localization for WWP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WWP1 Gene

Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WWP1 Gene COMPARTMENTS Subcellular localization image for WWP1 gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 3
plasma membrane 3
golgi apparatus 2
endosome 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for WWP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex NAS 9169421
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with WWP1: view

Pathways & Interactions for WWP1 Gene

genes like me logo Genes that share pathways with WWP1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9H0M0-WWP1_HUMAN

  • Pathway: Protein modification; protein ubiquitination

SIGNOR curated interactions for WWP1 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for WWP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 9169421
GO:0007417 central nervous system development NAS 9647693
GO:0016567 protein ubiquitination TAS 12535537
GO:0034220 ion transmembrane transport TAS --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with WWP1: view

Drugs & Compounds for WWP1 Gene

(1) Additional Compounds for WWP1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with WWP1: view

Transcripts for WWP1 Gene

Unigene Clusters for WWP1 Gene

WW domain containing E3 ubiquitin protein ligase 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WWP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WWP1 Gene

No ASD Table

Relevant External Links for WWP1 Gene

GeneLoc Exon Structure for
WWP1
ECgene alternative splicing isoforms for
WWP1

Expression for WWP1 Gene

mRNA expression in normal human tissues for WWP1 Gene

mRNA differential expression in normal tissues according to GTEx for WWP1 Gene

This gene is overexpressed in Muscle - Skeletal (x5.7).

Protein differential expression in normal tissues from HIPED for WWP1 Gene

This gene is overexpressed in CD8 Tcells (18.7), Gallbladder (16.7), Testis (16.6), Placenta (7.8), and Retina (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WWP1 Gene



SOURCE GeneReport for Unigene cluster for WWP1 Gene Hs.655189

mRNA Expression by UniProt/SwissProt for WWP1 Gene

Q9H0M0-WWP1_HUMAN
Tissue specificity: Detected in heart, placenta, pancreas, kidney, liver, skeletal muscle, bone marrow, fetal brain, and at much lower levels in adult brain and lung. Isoform 1 and isoform 5 predominate in all tissues tested, except in testis and bone marrow, where isoform 5 is expressed at much higher levels than isoform 1.
genes like me logo Genes that share expression patterns with WWP1: view

Protein tissue co-expression partners for WWP1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for WWP1 Gene

Orthologs for WWP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WWP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WWP1 35
  • 91.49 (n)
  • 93.59 (a)
WWP1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WWP1 35
  • 93.82 (n)
  • 95.23 (a)
WWP1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wwp1 35
  • 90.27 (n)
  • 90.96 (a)
Wwp1 16
Wwp1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WWP1 35
  • 99.89 (n)
  • 99.89 (a)
WWP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wwp1 35
  • 89.47 (n)
  • 90.85 (a)
oppossum
(Monodelphis domestica)
Mammalia WWP1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WWP1 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves WWP1 35
  • 79.91 (n)
  • 84.28 (a)
WWP1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WWP1 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wwp1 35
  • 73 (n)
  • 80.66 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19332 35
zebrafish
(Danio rerio)
Actinopterygii WWP1 36
  • 93 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Su(dx) 37
  • 71 (a)
Su(dx) 35
  • 56.08 (n)
  • 57.01 (a)
Su(dx) 36
  • 53 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009074 35
  • 55.65 (n)
  • 59.5 (a)
worm
(Caenorhabditis elegans)
Secernentea Y65B4BR.4a 37
  • 64 (a)
Y65B4BR.4b 37
  • 64 (a)
wwp-1 35
  • 60.43 (n)
  • 65.16 (a)
wwp-1 36
  • 55 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSP5 36
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9326 36
  • 72 (a)
OneToMany
Species with no ortholog for WWP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WWP1 Gene

ENSEMBL:
Gene Tree for WWP1 (if available)
TreeFam:
Gene Tree for WWP1 (if available)

Paralogs for WWP1 Gene

Paralogs for WWP1 Gene

(11) SIMAP similar genes for WWP1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for WWP1 Gene

genes like me logo Genes that share paralogs with WWP1: view

Variants for WWP1 Gene

Sequence variations from dbSNP and Humsavar for WWP1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1865864 -- 86,446,845(-) GTGTG(C/T)GTGCT intron-variant
rs2917554 -- 86,360,474(-) CAGGA(C/G)TAACA intron-variant
rs2917558 -- 86,433,250(+) ttttg(G/T)taact intron-variant
rs2953527 -- 86,404,725(-) TTCAA(A/G)GAGTT intron-variant
rs2953528 -- 86,394,983(-) GTTTT(C/T)TTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WWP1 Gene

Variant ID Type Subtype PubMed ID
nsv397543 CNV Insertion 16902084
esv2658378 CNV Deletion 23128226
esv1003777 CNV Insertion 20482838

Variation tolerance for WWP1 Gene

Residual Variation Intolerance Score: 9.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WWP1 Gene

HapMap Linkage Disequilibrium report
WWP1

PCR Panel Products

  • Copy Number PCR Panels: for WWP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WWP1 Gene

Disorders for WWP1 Gene

Relevant External Links for WWP1

Human Genome Epidemiology (HuGE) Navigator
WWP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WWP1
genes like me logo Genes that share disorders with WWP1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WWP1 Gene

Publications for WWP1 Gene

  1. A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover. (PMID: 19307600) Eastman S.W. … Bieniasz P.D. (J. Cell Biol. 2009) 23 67
  2. The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation. (PMID: 19047365) Feng S.M. … Earp H.S. (Mol. Cell. Biol. 2009) 23 67
  3. Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5. (PMID: 19580544) Edwards T.L. … Reid E. (Biochem. J. 2009) 23 67
  4. The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11. (PMID: 18724389) Chen C. … Seth A.K. (Oncogene 2008) 23 67
  5. The amplified WWP1 gene is a potential molecular target in breast cancer. (PMID: 17330240) Chen C. … Dong J.T. (Int. J. Cancer 2007) 23 67

Products for WWP1 Gene

Sources for WWP1 Gene

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