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WWP1 Gene

protein-coding   GIFtS: 60
GCID: GC08P087424

WW Domain Containing E3 Ubiquitin Protein Ligase 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WW Domain Containing E3 Ubiquitin Protein Ligase 11 2     hSDRP12
Atrophin-1-Interacting Protein 52 3     Nedd-4-Like Ubiquitin-Protein Ligase2
AIP52 3     NEDD4-Like E3 Ubiquitin-Protein Ligase WWP12
Tiul12 3     EC 6.3.2.-3
TGIF-Interacting Ubiquitin Ligase 12 3     TIUL15
WW Domain-Containing Protein 12 3     EC 6.3.28
Atrophin-1 Interacting Protein 52     

External Ids:    HGNC: 170041   Entrez Gene: 110592   Ensembl: ENSG000001231247   OMIM: 6023075   UniProtKB: Q9H0M03   

Export aliases for WWP1 gene to outside databases

Previous GC identifers: GC08P085970 GC08P087113 GC08P087337 GC08P087311 GC08P082564


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WWP1 Gene:
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide
variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a
protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus)
domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules
and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative
splicing of this gene generates at least 6 transcript variants; however, the full length nature of these
transcripts has not been defined. (provided by RefSeq, Jul 2008)

GeneCards Summary for WWP1 Gene:
WWP1 (WW domain containing E3 ubiquitin protein ligase 1) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is NEDD4L.

UniProtKB/Swiss-Prot: WWP1_HUMAN, Q9H0M0
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form
of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms
JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11
without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is
enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to
TGF-beta signaling, which requires interaction with TGIF

Gene Wiki entry for WWP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WWP1 gene promoter:
         MAZR   AML1a   Bach2   MIF-1   MEF-2A   PPAR-gamma1   HFH-1   aMEF-2   PPAR-gamma2   ATF6   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for WWP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WWP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21   Ensembl cytogenetic band:  8q21.3   HGNC cytogenetic band: 8q21.3

WWP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WWP1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P087424:  view genomic region     (about GC identifiers)

Start:
87,354,967 bp from pter      End:
87,490,649 bp from pter
Size:
135,683 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: WWP1_HUMAN, Q9H0M0 (See protein sequence)
Recommended Name: NEDD4-like E3 ubiquitin-protein ligase WWP1  
Size: 922 amino acids; 105202 Da
Subunit: Binds KLF2 AND HIVEP3 (By similarity). Binds SCNN1A, SCNN1B, SCNN1G, WBP1, WBP2, DRPLA and adenovirus
type 2 PIII. Interacts with RNF11 (By similarity). Interacts with SPG20. Interacts with ERBB4 isoforms JM-B CYT-1
and JM-A CYT-1. Interacts with SMAD1, SMAD2, SMAD3, SMAD5, SMAD6, SMAD7, TGFBR1 AND TGFBR2. Associates with the
TGFBR1:TGFBR2 receptor complex in presence of SMAD7. Interacts with SKIL isoform 1. Interacts with TP63 isoform 1
and isoform 2. Interacts with STAMBP and RNF11. Interacts with NDFIP1 and NDFIP2 (Probable); this interaction
activates the E3 ubiquitin-protein ligase. Interacts with TGIF
2 PDB 3D structures from and Proteopedia for WWP1:
1ND7 (3D)        2OP7 (3D)    
Secondary accessions: O00307 Q5YLC1 Q96BP4
Alternative splicing: 6 isoforms:  Q9H0M0-1   Q9H0M0-2   Q9H0M0-3   Q9H0M0-4   Q9H0M0-5   Q9H0M0-6   

Explore the universe of human proteins at neXtProt for WWP1: NX_Q9H0M0

Explore proteomics data for WWP1 at MOPED

Post-translational modifications: 

  • Auto-ubiquitinated and ubiquitinated by RNF111
  • Ubiquitination2 at Lys464, Lys684, Lys900
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for WWP1 (Q9H0M0) (see all 14)
     LQINPAS  PLPPGWE  TQWEDPR  RLLQFVTG 


    See WWP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008944.1  
    ENSEMBL proteins: 
     ENSP00000427793   ENSP00000429076   ENSP00000430228   ENSP00000265428   ENSP00000340564  
     ENSP00000342665  
    Reactome Protein details: Q9H0M0

    WWP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for WWP1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for WWP1
    GenScript Custom Purified and Recombinant Proteins Services for WWP1
    Novus Biologicals WWP1 Protein
    Novus Biologicals WWP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WWP1

     
    Search eBioscience for Proteins for WWP1 

    WWP1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for WWP1
    Novus Biologicals WWP1 Antibodies
    Abcam antibodies for WWP1
    Cloud-Clone Corp. Antibodies for WWP1
    Search ThermoFisher Antibodies for WWP1
    LSBio Antibodies in human, mouse, rat for WWP1

    WWP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for WWP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for WWP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for WWP1
    Cloud-Clone Corp. CLIAs for WWP1
    Search eBioscience for ELISAs for WWP1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR024928 E3_ub_ligase_SMURF1
     IPR000569 HECT
     IPR001202 WW_dom
     IPR000008 C2_dom

    Graphical View of Domain Structure for InterPro Entry Q9H0M0

    ProtoNet protein and cluster: Q9H0M0

    3 Blocks protein domains:
    IPB000008 C2 domain
    IPB000569 HECT domain (Ubiquitin-protein ligase)
    IPB002349 WW domain signature


    UniProtKB/Swiss-Prot: WWP1_HUMAN, Q9H0M0
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain
    Similarity: Contains 4 WW domains


    Find genes that share domains with WWP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WWP1_HUMAN, Q9H0M0
    Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form
    of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms
    JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11
    without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is
    enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to
    TGF-beta signaling, which requires interaction with TGIF
    Enzyme regulation: Activated by NDFIP1- and NDFIP2-binding

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity TAS9169421
    GO:0005515protein binding IPI16189514
         
    Find genes that share ontologies with WWP1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for WWP1:
     Increased S DNA content  Increased number of mitotic ce 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Wwp1):
     cellular  skeleton 

    Find genes that share phenotypes with WWP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Wwp1tm1Lmat for WWP1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WWP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for WWP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WWP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WWP1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat WWP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WWP1 (see all 36):
    hsa-miR-142-5p hsa-miR-2052 hsa-miR-19b-2* hsa-miR-15a hsa-let-7a-2* hsa-miR-30d hsa-miR-507 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidWWP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for WWP1
    Predesigned siRNA for gene silencing in human, mouse, rat WWP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for WWP1

    Clone
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    OriGene clones in human, mouse for WWP1 (see all 7)
    OriGene ORF clones in mouse, rat for WWP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WWP1 (NM_007013)
    Sino Biological Human cDNA Clone for WWP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WWP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WWP1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for WWP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for WWP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WWP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WWP1_HUMAN, Q9H0M0: Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein (By similarity).
    Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol4
    nucleus3
    mitochondrion2
    golgi apparatus1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex NAS9169421
    GO:0005634nucleus IBA--
    GO:0005737cytoplasm IBA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--

    Find genes that share ontologies with WWP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WWP1 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    2PI-3K cascade
    Signaling by ERBB40.66
    Downregulation of ERBB4 signaling0.00
    3Ion channel transport
    Ion channel transport0.58
    Stimuli-sensing channels0.58
    4Signaling by GPCR
    Signal Transduction0.58
    5Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47


    Find genes that share SuperPaths with WWP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for WWP1
        SMAD Signaling Network
    Ubiquitin-Proteasome Dependent Proteolysis

    2 BioSystems Pathways for WWP1
        ErbB4 signaling events
    TGF-beta receptor signaling


    3 Reactome Pathways for WWP1
        Antigen processing: Ubiquitination & Proteasome degradation
    Stimuli-sensing channels
    Downregulation of ERBB4 signaling


    2 Kegg Pathways  (Kegg details for WWP1):
        Ubiquitin mediated proteolysis
    Endocytosis

    UniProtKB/Swiss-Prot: WWP1_HUMAN, Q9H0M0
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WWP1: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for WWP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WWP1 (Q9H0M01, 2, 3 ENSP000002654284) via UniProtKB, MINT, STRING, and/or I2D (see all 182)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATN1P542592, 3, ENSP000003490764MINT-2869242 I2D: score=6 STRING: ENSP00000349076
    ZNF638Q149662, 3, ENSP000002644474MINT-66246 I2D: score=5 STRING: ENSP00000264447
    LAPTM5Q135712, 3, ENSP000002945074MINT-62179 I2D: score=3 STRING: ENSP00000294507
    SMAD5Q997172, 3MINT-61842 I2D: score=4 
    CPSF6Q166301, 2, 3, ENSP000003917744EBI-742157,EBI-358410 MINT-66359 I2D: score=6 STRING: ENSP00000391774
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction NAS9169421
    GO:0007417central nervous system development NAS9647693
    GO:0016567protein ubiquitination TAS12535537
    GO:0019048modulation by virus of host morphology or physiology ----
    GO:0034220ion transmembrane transport TAS--

    Find genes that share ontologies with WWP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WWP1

    1 Novoseek inferred chemical compound relationship for WWP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sodium 13.5 1 12908109 (1)



    Find genes that share compounds with WWP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WWP1 gene: 
    NM_007013.3  

    Unigene Cluster for WWP1:

    WW domain containing E3 ubiquitin protein ligase 1
    Hs.655189  [show with all ESTs]
    Unigene Representative Sequence: NM_007013
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000517970(uc003ydt.3) ENST00000523863 ENST00000518683(uc010mai.3)
    ENST00000520374 ENST00000521079 ENST00000520453 ENST00000521997 ENST00000524036
    ENST00000520521 ENST00000520798 ENST00000265428 ENST00000341922 ENST00000349423

    miRNA
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    Block miRNA regulation of human, mouse, rat WWP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WWP1 (see all 36):
    hsa-miR-142-5p hsa-miR-2052 hsa-miR-19b-2* hsa-miR-15a hsa-let-7a-2* hsa-miR-30d hsa-miR-507 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidWWP1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for WWP1
    Predesigned siRNA for gene silencing in human, mouse, rat WWP1
    Clone
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    OriGene ORF clones in mouse, rat for WWP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WWP1 (NM_007013)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WWP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WWP1
    Primer
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    OriGene qPCR primer pairs and template standards for WWP1
    OriGene qSTAR qPCR primer pairs in human, mouse for WWP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WWP1
      QuantiTect SYBR Green Assays in human, mouse, rat WWP1
      QuantiFast Probe-based Assays in human, mouse, rat WWP1

    Additional mRNA sequence: 

    AK292800.1 AK310683.1 AL050082.1 AL136739.1 AY043361.1 AY345857.1 BC015380.2 BC036065.1 
    U96113.1 

    14 DOTS entries:

    DT.454643  DT.40193839  DT.121472624  DT.121472629  DT.99944662  DT.120893315  DT.95166238  DT.100715649 
    DT.120878343  DT.120907932  DT.91885604  DT.97805830  DT.95254069  DT.99999668 

    Selected AceView cDNA sequences (see all 234):

    D82380 AI804339 AA393281 CB163171 BM703929 AA455942 BM090672 AI373068 
    BE504125 AW198099 AI159868 AA922647 AW513675 H88930 N53633 AA832035 
    AL049041 CB163725 BU509208 BC015380 BX280230 AL136739 AY043361 BF445478 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WWP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGTTCAGA
    WWP1 Expression
    About this image

    WWP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WWP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655189

    UniProtKB/Swiss-Prot: WWP1_HUMAN, Q9H0M0
    Tissue specificity: Detected in heart, placenta, pancreas, kidney, liver, skeletal muscle, bone marrow, fetal
    brain, and at much lower levels in adult brain and lung. Isoform 1 and isoform 5 predominate in all tissues
    tested, except in testis and bone marrow, where isoform 5 is expressed at much higher levels than isoform 1

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WWP1: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for WWP1
    OriGene qSTAR qPCR primer pairs in human, mouse for WWP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WWP1
    QuantiTect SYBR Green Assays in human, mouse, rat WWP1
    QuantiFast Probe-based Assays in human, mouse, rat WWP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WWP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for WWP1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wwp11 , 5 WW domain containing E3 ubiquitin protein ligase 11, 5 90.27(n)1
    90.96(a)1
      4 (7.56 cM)5
    1075681  NM_177327.51  NP_796301.21 
     196083035 
    chicken
    (Gallus gallus)
    Aves WWP11 WW domain containing E3 ubiquitin protein ligase 1 79.91(n)
    84.28(a)
      420212  NM_001012554.2  NP_001012572.1 
    lizard
    (Anolis carolinensis)
    Reptilia WWP16
    WW domain containing E3 ubiquitin protein ligase 1...
    81(a)
    1 ↔ 1
    4(22820727-22854465)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.193322 Xenopus laevis transcribed sequence with strong similarity more 80.58(n)    BQ384711.1 
    zebrafish
    (Danio rerio)
    Actinopterygii WWP16
    WW domain containing E3 ubiquitin protein ligase 1...
    93(a)
    1 ↔ 1
    24(43905429-43909613) ENSDARG00000097537
    fruit fly
    (Drosophila melanogaster)
    Insecta Su(dx)1 , 3 N receptor signaling pathway
    ubiquitin-protein more3
    Suppressor of deltex1
    71(a)3
    56.08(n)1
    57.01(a)1
      2 22C13
    333791  NM_164449.21  NP_722754.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y65B4BR.4a3
    wwp-11
    wwp-11 64(a)
    (best of 2)3
    60.43(n)1
    65.16(a)1
      I(537141-541634)3
    1716471  NM_170794.61  NP_740775.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RSP56
    E3 ubiquitin ligase of the NEDD4 family; involved ...
    39(a)
    1 → many
    V(410189-412618) YER125W


    ENSEMBL Gene Tree for WWP1 (if available)
    TreeFam Gene Tree for WWP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WWP1 gene
    NEDD4L2  HECW22  AREL12  UBR52  WWP22  SMURF22  HECW12  SMURF12  
    HUWE12  NEDD42  ITCH2  
    11 SIMAP similar genes for WWP1 using alignment to 3 protein entries:     WWP1_HUMAN (see all proteins):
    ITCH    WWP2    HUWE1    HACE1    NEDD4L    NEDD4
    SMURF1    SMURF2    HECW1    HECW2    NEDL1

    Find genes that share paralogs with WWP1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for WWP1
    PGOHUM00000238113


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WWP1 (see all 2510)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1166461951,2
    C,F--87353012(+) TTTGAT/GGCTGG 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs794643471,2
    --87353102(+) TTTTTA/GTTACT 1 -- us2k10--------
    rs1862576641,2
    C--87353148(+) GAACAA/GTGGTT 1 -- us2k10--------
    rs1905697461,2
    --87353195(+) AAACAC/GTCAAT 1 -- us2k10--------
    rs1833766601,2
    --87353267(+) TGAACA/GGGGAG 1 -- us2k10--------
    rs1451343901,2
    C--87353363(+) CTGCT-/GGGGGA 1 -- us2k10--------
    rs726885551,2
    C--87353365(+) TGCTGC/GGGAAT 1 -- us2k10--------
    rs1463698701,2
    --87353374(+) ATACCA/TACGGA 1 -- us2k10--------
    rs125493321,2
    C,F,A,H--87353392(+) AGGACG/ATGTTT 1 -- us2k110Minor allele frequency- A:0.34NA CSA WA EA 372
    rs726885561,2
    C,F--87353397(+) GTGTTT/GGTAAG 1 -- us2k11Minor allele frequency- G:0.08NA 120

    HapMap Linkage Disequilibrium report for WWP1 (87354967 - 87490649 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for WWP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658378CNV Deletion23128226
    esv1003777CNV Insertion20482838
    nsv397543CNV Insertion16902084

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing WWP1:
    Prostate Cancer
    SeqTarget long-range PCR primers for resequencing WWP1
    DNA2.0 Custom Variant and Variant Library Synthesis for WWP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602307    OMIM disorders: --


    Find genes that share disorders with WWP1           About GenesLikeMe

    1 Novoseek inferred disease relationship for WWP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 4 17330240 (3)

    Human Genome Epidemiology (HuGE) Navigator: WWP1 (1 document)

    Export disorders for WWP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WWP1 gene, integrated from 10 sources (see all 76):
    (articles sorted by number of sources associating them with WWP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. (PubMed id 9647693)1, 2, 3 Wood J.D.... Ross C.A. (Mol. Cell. Neurosci. 1998)
    2. Identification of novel human WW domain-containing proteins by cloning of ligand targets. (PubMed id 9169421)1, 2, 3 Pirozzi G.... Fowlkes D.M. (J. Biol. Chem. 1997)
    3. The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11. (PubMed id 18724389)1, 2, 9 Chen C.... Seth A.K. (Oncogene 2008)
    4. Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein. (PubMed id 11779188)1, 2, 9 Flasza M.... Baron M. (Biochem. Biophys. Res. Commun. 2002)
    5. Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5. (PubMed id 19580544)1, 2, 9 Edwards T.L.... Reid E. (Biochem. J. 2009)
    6. Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1). (PubMed id 15221015)1, 2, 9 Komuro A....Miyazawa K. (Oncogene 2004)
    7. Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases. (PubMed id 12450395)1, 2, 9 Galinier R.... Chroboczek J. (Biochemistry 2002)
    8. The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation. (PubMed id 15359284)1, 2, 9 Seo S.R....Atfi A. (EMBO J. 2004)
    9. Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins. (PubMed id 19343052)1, 2 Mund T. and Pelham H.R. (EMBO Rep. 2009)
    10. WW domain containing E3 ubiquitin protein ligase 1 targets the full- length ErbB4 for ubiquitin-mediated degradation in breast cancer. (PubMed id 19561640)1, 2 Li Y.... Chen C. (Oncogene 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11059 HGNC: 17004 AceView: WWP1 Ensembl:ENSG00000123124 euGenes: HUgn11059
    ECgene: WWP1 Kegg: 11059 H-InvDB: WWP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WWP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WWP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WWP1 gene:
    Search GeneIP for patents involving WWP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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