WWP1 Gene
protein-coding GIFtS: 57
GCID: GC08P087424
|
|
WW domain containing E3 ubiquitin protein ligase 1
| |
Aliases
for WWP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WW Domain Containing E3 Ubiquitin Protein Ligase 11 2 | | Atrophin-1 Interacting Protein 52 | | AIP51 2 3 | | HSDRP11 | | Atrophin-1-Interacting Protein 52 3 | | Nedd-4-Like Ubiquitin-Protein Ligase2 | | Tiul12 3 | | NEDD4-Like E3 Ubiquitin-Protein Ligase WWP12 | | TGIF-Interacting Ubiquitin Ligase 12 3 | | EC 6.3.2.-3 | | WW Domain-Containing Protein 12 3 | | TIUL15 | | DKFZP434D21111 | | EC 6.3.28 |
Export aliases for WWP1 gene to outside databasesPrevious GC identifers: GC08P085970 GC08P087113 GC08P087337 GC08P087311 GC08P082564 |
Summaries
for WWP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for WWP1:
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a widevariety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes aprotein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus)domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules andregulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicingof this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has notbeen defined. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: WWP1_HUMAN, Q9H0M0Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of athioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targetingit for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7.Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling,which requires interaction with TGIF
Gene Wiki entry for WWP1
|
Genomic Views
for WWP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WWP1 gene promoter:
MAZR AML1a Bach2 MIF-1 MEF-2A PPAR-gamma1 HFH-1 aMEF-2 PPAR-gamma2 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for WWP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WWP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q21 Ensembl cytogenetic band: 8q21.3 HGNC cytogenetic band: 8q21WWP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P087424: view genomic region
(about GC identifiers)
Start:
|
87,354,967 bp from pter |
End:
|
87,490,649 bp from pter |
Size:
|
135,683 bases |
Orientation:
|
plus strand |
|
Proteins
for WWP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WWP1_HUMAN, Q9H0M0 (See
protein sequence)Recommended Name: NEDD4-like E3 ubiquitin-protein ligase WWP1 Size: 922 amino acids; 105202 Da
Subunit: Binds KLF2 AND HIVEP3 (By similarity). Binds SCNN1A, SCNN1B, SCNN1G, WBP1, WBP2, DRPLA and adenovirus type 2PIII. Interacts with RNF11 (By similarity). Interacts with SPG20. Interacts with ERBB4 isoforms JM-B CYT-1 and JM-ACYT-1. Interacts with SMAD1, SMAD2, SMAD3, SMAD5, SMAD6, SMAD7, TGFBR1 AND TGFBR2. Associates with the TGFBR1:TGFBR2receptor complex in presence of SMAD7. Interacts with SKIL isoform 1. Interacts with TP63 isoform 1 and isoform 2.Interacts with STAMBP and RNF11. Interacts with NDFIP1 and NDFIP2 (Probable); this interaction activates the E3ubiquitin-protein ligase. Interacts with TGIF
Subcellular location: Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Nucleus(By similarity)
2 PDB 3D structures from  and Proteopedia  for WWP1:1ND7 (3D)
2OP7 (3D)
Secondary accessions: O00307 Q5YLC1 Q96BP4Alternative splicing: 6 isoforms: Q9H0M0-1 Q9H0M0-2 Q9H0M0-3 Q9H0M0-4 Q9H0M0-5 Q9H0M0-6 Explore the universe of human proteins at neXtProt for WWP1: NX_Q9H0M0
Post-translational modifications:
Auto-ubiquitinated and ubiquitinated by RNF111
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H0M0
4/14 DME Specific Peptides for WWP1 (Q9H0M0) (see all 14)
WWP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_008944.1
ENSEMBL proteins: ENSP00000427793 ENSP00000429076 ENSP00000430228 ENSP00000265428 ENSP00000340564 ENSP00000342665 Reactome Protein details: Q9H0M0
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
WWP1 for ontologies About GeneDecksing
WWP1 Antibody Products:
Assay Products for WWP1: |
Protein
Domains /
Families
for WWP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WWP1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9H0M0ProtoNet protein and cluster: Q9H0M0 3 Blocks protein families: IPB000008 C2 domain IPB000569 HECT domain (Ubiquitin-protein ligase) IPB002349 WW domain signature
UniProtKB/Swiss-Prot: WWP1_HUMAN, Q9H0M0Similarity: Contains 1 C2 domainSimilarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domainSimilarity: Contains 4 WW domains |
Function
for WWP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: WWP1_HUMAN, Q9H0M0Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of athioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targetingit for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7.Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling,which requires interaction with TGIFEnzyme regulation: Activated by NDFIP1- and NDFIP2-bindingEnzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WWP1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WWP1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: WWP1 (NM_007013) | |  | Sino Biological Human cDNA Clone for WWP1 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WWP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WWP1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WWP1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
WWP1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for WWP1:
Animal Models:
Mouse knock-out Wwp1tm1Lmat for WWP1
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Wwp1):
WWP1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for WWP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Antigen processing: Ubiquitination & Proteasome degradation | | | 2 | Immune System | | | 3 | Ion channel transport | | | 4 | Ubiquitin-Proteasome Dependent Proteolysis | | | 5 | SMAD Signaling Network | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for WWP1
2  BioSystems Pathways for WWP1
5/11 
Reactome Pathways for WWP1 (see all 11)
2 
Kegg Pathways (Kegg details for WWP1):
UniProtKB/Swiss-Prot: WWP1_HUMAN, Q9H0M0Pathway: Protein modification; protein ubiquitination
WWP1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WWP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/93 Interacting proteins for WWP1 (Q9H0M01, 2, 3 ENSP000002654284) via UniProtKB, MINT, STRING, and/or I2D (see all 93)
| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| CPSF6 | Q166301, 2, 3, ENSP000003917744 | EBI-742157,EBI-740029 MINT-66359 I2D:
score=6 STRING: ENSP00000391774 | | ZNF638 | Q149662, 3, ENSP000002644474 | MINT-66246 I2D:
score=5 STRING: ENSP00000264447 | | RNF11 | Q9Y3C52, 3, ENSP000002427194 | MINT-60884 I2D:
score=4 STRING: ENSP00000242719 | | LAPTM5 | Q135712, 3, ENSP000002945074 | MINT-62179 I2D:
score=3 STRING: ENSP00000294507 | | SMAD5 | Q997172, 3 | MINT-61842 I2D:
score=4 |
About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
WWP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for WWP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
WWP1 for compounds About GeneDecksing
 Browse Tocris compounds for WWP1
1 Novoseek chemical compound relationship for WWP1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| sodium |
13.5 |
1 |
12908109 (1) |
Search CenterWatch for drugs/clinical trials and news about WWP1
|
Transcripts
for WWP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WWP1 gene: NM_007013.3 Unigene Cluster for WWP1: WW domain containing E3 ubiquitin protein ligase 1 Hs.655189 [show with all ESTs]Unigene Representative Sequence: NM_00701313 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000517970(uc003ydt.3) ENST00000523863 ENST00000518683(uc010mai.3)
ENST00000520374 ENST00000521079 ENST00000520453 ENST00000521997 ENST00000524036
ENST00000520521 ENST00000520798 ENST00000265428 ENST00000341922 ENST00000349423
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WWP1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WWP1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: WWP1 (NM_007013) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WWP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WWP1 |
Additional cDNA sequence: AK292800.1 AK310683.1 AL050082.1 AL136739.1 AY043361.1 AY345857.1 BC015380.2 BC036065.1 U96113.1 14 DOTS entries: DT.454643 DT.40193839 DT.121472624 DT.121472629 DT.99944662 DT.120893315 DT.95166238 DT.100715649 DT.120878343 DT.120907932 DT.91885604 DT.97805830 DT.95254069 DT.99999668 24/234 AceView cDNA sequences (see all 234): BM981146 CB114971 AI800660 D82113 R67562 AI799752 AL040820 W92048 AI214271 CA395428 W92065 AA680229 AI187909 NM_007013 CB122578 AI091728 AA354846 BE463596 AW474462 AI417440 BC036065 H89156 AI342285 BE906331
GeneLoc Exon Structure
|
Expression
for WWP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WWP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTGTTCAGA
About this image
See WWP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WWP1
SOURCE GeneReport for Unigene cluster: Hs.655189
UniProtKB/Swiss-Prot: WWP1_HUMAN, Q9H0M0Tissue specificity: Detected in heart, placenta, pancreas, kidney, liver, skeletal muscle, bone marrow, fetal brain,and at much lower levels in adult brain and lung. Isoform 1 and isoform 5 predominate in all tissues tested, except intestis and bone marrow, where isoform 5 is expressed at much higher levels than isoform 1
SABiosciences Expression via Pathway-Focused PCR Arrays including WWP1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WWP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WWP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WWP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WWP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WWP1 |
Orthologs
for WWP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for WWP1 gene from 6/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
WWP11 |
WW domain containing E3 ubiquitin protein ligase 1 |
79.91(n)
84.28(a) |
|
420212 NM_001012554.1 NP_001012572.1 |
lizard
(Anolis carolinensis) |
Reptilia |
WWP16 |
-- |
81(a) |
1 ↔ 1 |
4(22820727-22854465) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.193322 |
Xenopus laevis transcribed sequence with strong similarity more |
80.58(n) |
|
BQ384711.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC1005363951 |
NEDD4-like E3 ubiquitin-protein ligase WWP1-like |
65.66(n)
75.38(a) |
|
100536395 XM_003201365.1 XP_003201413.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Su(dx)1 , 3 |
N receptor signaling pathway
ubiquitin-protein more3
Suppressor of deltex1 |
71(a)3
55.93(n)1
57.01(a)1 |
|
2 22C13
333791 NM_057405.21 NP_476753.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
Y65B4BR.4a3
wwp-11 |
Protein WWP-11 |
64(a)
(best of 2)3
60.05(n)1
65(a)1 |
|
I(537141-541634)3
1716471 NM_171831.21 NP_740776.11 |
ENSEMBL Gene Tree for WWP1 (if available)
TreeFam Gene Tree for WWP1 (if available) |
Paralogs
for WWP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for WWP1 gene
- NEDD4L2 HECW22 HACE12 WWP22 KIAA03172 SMURF22 HECW12 SMURF12
- ITCH2 NEDD42
12 SIMAP similar genes for WWP1 using alignment to 3 protein entries: WWP1_HUMAN (see all proteins):WWP2 ITCH HUWE1 HACE1 NEDD4L NEDD4
SMURF1 SMURF2 HECW1 HECW2 NEDL1 PIN1P1
WWP1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for WWP1
PGOHUM00000238113
|
Genomic Variants
for WWP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WWP1 (87354967 - 87490649 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for WWP1: -- | SABiosciences Cancer Mutation PCR Assays |
| 1 SABiosciences qBiomarker Copy Number PCR Array containing WWP1: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WWP1 |
|
Disorders
/ Diseases
for WWP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WWP1 for disorders About GeneDecksing
OMIM gene information: 602307
OMIM disorders: --
16  diseases for WWP1: About MalaCardshuman t-cell leukemia virus type 1 liddle syndrome chronic lymphocytic leukemia lymphocytic leukemia
t-cell leukemia gout leukemia pharyngitis
breast carcinoma prostate cancer breast cancer ataxia
prostatitis carcinoma malaria neuronitis
1 Novoseek disease relationship for WWP1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0 |
4 |
17330240 (3) |
Human Genome Epidemiology (HuGE) Navigator: WWP1 (1 document)
Export disorders for WWP1 gene to outside databases
|
Publications
for WWP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WWP1 gene, integrated from 9 sources (see all 66):
(articles sorted by number of sources associating them with WWP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. (PubMed id 9647693)1, 2, 3 Wood J.D.... Ross C.A. (1998)
- Identification of novel human WW domain-containing proteins by cloning of ligand targets. (PubMed id 9169421)1, 2, 3 Pirozzi G.... Fowlkes D.M. (1997)
- The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11. (PubMed id 18724389)1, 2, 9 Chen C.... Seth A.K. (2008)
- Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein. (PubMed id 11779188)1, 2, 9 Flasza M.... Baron M. (2002)
- Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5. (PubMed id 19580544)1, 2, 9 Edwards T.L....Reid E. (2009)
- Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1). (PubMed id 15221015)1, 2, 9 Komuro A....Miyazawa K. (2004)
- Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases. (PubMed id 12450395)1, 2, 9 Galinier R.... Chroboczek J. (2002)
- The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation. (PubMed id 15359284)1, 2, 9 Seo S.R....Atfi A. (2004)
- Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins. (PubMed id 19343052)1, 2 Mund T. and Pelham H.R. (2009)
- WW domain containing E3 ubiquitin protein ligase 1 ta rgets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer . (PubMed id 19561640)1, 2 Li Y....Chen C. (2009)
|
External Searches for WWP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing WWP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing WWP1 gene
(According to HUGE)
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Specialized Databases showing WWP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for WWP1 gene:
Search GeneIP for patents involving WWP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for WWP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for WWP1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WWP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WWP1 | | | OriGene Protein Over-expression Lysate for WWP1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for WWP1 | | OriGene 3'-UTR Clone for WWP1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WWP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WWP1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for WWP1 | | OriGene Custom Protein Services for WWP1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WWP1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WWP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WWP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WWP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WWP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WWP1 |
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| | | | Search Tocris compounds for WWP1 |
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 | | | WWP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WWP1 |
|  |  |  | | | | Search ThermoFisher Antibodies for WWP1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WWP1 |
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