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Aliases for WWP1 Gene

Aliases for WWP1 Gene

  • WW Domain Containing E3 Ubiquitin Protein Ligase 1 2 3 5
  • TGIF-Interacting Ubiquitin Ligase 1 3 4
  • Atrophin-1-Interacting Protein 5 3 4
  • WW Domain-Containing Protein 1 3 4
  • Tiul1 3 4
  • AIP5 3 4
  • Nedd-4-Like Ubiquitin-Protein Ligase 3
  • Atrophin-1 Interacting Protein 5 3
  • EC 6.3.2.- 4
  • EC 6.3.2 63
  • HSDRP1 3

External Ids for WWP1 Gene

Previous GeneCards Identifiers for WWP1 Gene

  • GC08P085970
  • GC08P087113
  • GC08P087337
  • GC08P087311
  • GC08P087424
  • GC08P082564

Summaries for WWP1 Gene

Entrez Gene Summary for WWP1 Gene

  • WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]

GeneCards Summary for WWP1 Gene

WWP1 (WW Domain Containing E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Among its related pathways are Ion channel transport and Antigen processing- Ubiquitination and Proteasome degradation. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is AREL1.

UniProtKB/Swiss-Prot for WWP1 Gene

  • E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.

Gene Wiki entry for WWP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WWP1 Gene

Genomics for WWP1 Gene

Regulatory Elements for WWP1 Gene

Enhancers for WWP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WWP1 on UCSC Golden Path with GeneCards custom track

Promoters for WWP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WWP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for WWP1 Gene

Chromosome:
8
Start:
86,342,736 bp from pter
End:
86,478,420 bp from pter
Size:
135,685 bases
Orientation:
Plus strand

Genomic View for WWP1 Gene

Genes around WWP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WWP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WWP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WWP1 Gene

Proteins for WWP1 Gene

  • Protein details for WWP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0M0-WWP1_HUMAN
    Recommended name:
    NEDD4-like E3 ubiquitin-protein ligase WWP1
    Protein Accession:
    Q9H0M0
    Secondary Accessions:
    • O00307
    • Q5YLC1
    • Q96BP4

    Protein attributes for WWP1 Gene

    Size:
    922 amino acids
    Molecular mass:
    105202 Da
    Quaternary structure:
    • Binds KLF2 AND HIVEP3 (By similarity). Binds SCNN1A, SCNN1B, SCNN1G, WBP1, WBP2, DRPLA and adenovirus type 2 PIII. Interacts with RNF11 (By similarity). Interacts with SPG20. Interacts with ERBB4 isoforms JM-B CYT-1 and JM-A CYT-1. Interacts with SMAD1, SMAD2, SMAD3, SMAD5, SMAD6, SMAD7, TGFBR1 AND TGFBR2. Associates with the TGFBR1:TGFBR2 receptor complex in presence of SMAD7. Interacts with SKIL isoform 1. Interacts with TP63 isoform 1 and isoform 2. Interacts with STAMBP and RNF11. Interacts with NDFIP1 and NDFIP2 (Probable); this interaction activates the E3 ubiquitin-protein ligase. Interacts with TGIF.

    Three dimensional structures from OCA and Proteopedia for WWP1 Gene

    Alternative splice isoforms for WWP1 Gene

neXtProt entry for WWP1 Gene

Proteomics data for WWP1 Gene at MOPED

Post-translational modifications for WWP1 Gene

Other Protein References for WWP1 Gene

Domains & Families for WWP1 Gene

Gene Families for WWP1 Gene

Suggested Antigen Peptide Sequences for WWP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0M0

UniProtKB/Swiss-Prot:

WWP1_HUMAN :
  • Contains 1 C2 domain.
Domain:
  • Contains 1 C2 domain.
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
  • Contains 4 WW domains.
genes like me logo Genes that share domains with WWP1: view

Function for WWP1 Gene

Molecular function for WWP1 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by NDFIP1- and NDFIP2-binding.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.

Enzyme Numbers (IUBMB) for WWP1 Gene

Gene Ontology (GO) - Molecular Function for WWP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA,TAS 9169421
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with WWP1: view
genes like me logo Genes that share phenotypes with WWP1: view

Animal Models for WWP1 Gene

MGI Knock Outs for WWP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for WWP1

miRNA for WWP1 Gene

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WWP1 Gene

Localization for WWP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WWP1 Gene

Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WWP1 Gene COMPARTMENTS Subcellular localization image for WWP1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 4
plasma membrane 4
golgi apparatus 2
mitochondrion 2
endoplasmic reticulum 1
endosome 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for WWP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with WWP1: view

Pathways & Interactions for WWP1 Gene

genes like me logo Genes that share pathways with WWP1: view

UniProtKB/Swiss-Prot Q9H0M0-WWP1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for WWP1 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for WWP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007417 central nervous system development NAS 9647693
GO:0016567 protein ubiquitination TAS 12535537
GO:0034220 ion transmembrane transport TAS --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with WWP1: view

Drugs & Compounds for WWP1 Gene

(1) Additional Compounds for WWP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with WWP1: view

Transcripts for WWP1 Gene

Unigene Clusters for WWP1 Gene

WW domain containing E3 ubiquitin protein ligase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WWP1 Gene

No ASD Table

Relevant External Links for WWP1 Gene

GeneLoc Exon Structure for
WWP1
ECgene alternative splicing isoforms for
WWP1

Expression for WWP1 Gene

mRNA expression in normal human tissues for WWP1 Gene

mRNA differential expression in normal tissues according to GTEx for WWP1 Gene

This gene is overexpressed in Muscle - Skeletal (x5.7).

Protein differential expression in normal tissues from HIPED for WWP1 Gene

This gene is overexpressed in CD8 Tcells (18.7), Gallbladder (16.7), Testis (16.6), Placenta (7.8), and Retina (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WWP1 Gene



SOURCE GeneReport for Unigene cluster for WWP1 Gene Hs.655189

mRNA Expression by UniProt/SwissProt for WWP1 Gene

Q9H0M0-WWP1_HUMAN
Tissue specificity: Detected in heart, placenta, pancreas, kidney, liver, skeletal muscle, bone marrow, fetal brain, and at much lower levels in adult brain and lung. Isoform 1 and isoform 5 predominate in all tissues tested, except in testis and bone marrow, where isoform 5 is expressed at much higher levels than isoform 1.
genes like me logo Genes that share expression patterns with WWP1: view

Protein tissue co-expression partners for WWP1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for WWP1 Gene

Orthologs for WWP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WWP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WWP1 35
  • 91.49 (n)
  • 93.59 (a)
WWP1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WWP1 35
  • 93.82 (n)
  • 95.23 (a)
WWP1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wwp1 35
  • 90.27 (n)
  • 90.96 (a)
Wwp1 16
Wwp1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WWP1 35
  • 99.89 (n)
  • 99.89 (a)
WWP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wwp1 35
  • 89.47 (n)
  • 90.85 (a)
oppossum
(Monodelphis domestica)
Mammalia WWP1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WWP1 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves WWP1 35
  • 79.91 (n)
  • 84.28 (a)
WWP1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WWP1 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wwp1 35
  • 73 (n)
  • 80.66 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19332 35
zebrafish
(Danio rerio)
Actinopterygii WWP1 36
  • 93 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Su(dx) 37
  • 71 (a)
Su(dx) 35
  • 56.08 (n)
  • 57.01 (a)
Su(dx) 36
  • 53 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009074 35
  • 55.65 (n)
  • 59.5 (a)
worm
(Caenorhabditis elegans)
Secernentea Y65B4BR.4a 37
  • 64 (a)
Y65B4BR.4b 37
  • 64 (a)
wwp-1 35
  • 60.43 (n)
  • 65.16 (a)
wwp-1 36
  • 55 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSP5 36
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9326 36
  • 72 (a)
OneToMany
Species with no ortholog for WWP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WWP1 Gene

ENSEMBL:
Gene Tree for WWP1 (if available)
TreeFam:
Gene Tree for WWP1 (if available)

Paralogs for WWP1 Gene

Paralogs for WWP1 Gene

(11) SIMAP similar genes for WWP1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for WWP1 Gene

genes like me logo Genes that share paralogs with WWP1: view

Variants for WWP1 Gene

Sequence variations from dbSNP and Humsavar for WWP1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_052960 -
rs7830128 -- 86,361,011(+) AGAAG(A/G)AAGAG intron-variant
rs7830480 -- 86,390,908(+) CCTAT(C/T)GTTTT intron-variant
rs7832493 -- 86,359,304(+) ATGCT(A/C)TAAAC intron-variant
rs7833049 -- 86,433,669(+) cttgt(C/T)atggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WWP1 Gene

Variant ID Type Subtype PubMed ID
nsv397543 CNV Insertion 16902084
esv2658378 CNV Deletion 23128226
esv1003777 CNV Insertion 20482838

Variation tolerance for WWP1 Gene

Residual Variation Intolerance Score: 9.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for WWP1 Gene

Disorders for WWP1 Gene

Relevant External Links for WWP1

Human Genome Epidemiology (HuGE) Navigator
WWP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WWP1

No disorders were found for WWP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WWP1 Gene

Publications for WWP1 Gene

  1. Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. (PMID: 9647693) Wood J.D. … Ross C.A. (Mol. Cell. Neurosci. 1998) 2 3 4 67
  2. The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation. (PMID: 19047365) Feng S.M. … Earp H.S. (Mol. Cell. Biol. 2009) 3 23
  3. A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover. (PMID: 19307600) Eastman S.W. … Bieniasz P.D. (J. Cell Biol. 2009) 3 23
  4. Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5. (PMID: 19580544) Edwards T.L. … Reid E. (Biochem. J. 2009) 3 23
  5. The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11. (PMID: 18724389) Chen C. … Seth A.K. (Oncogene 2008) 3 23

Products for WWP1 Gene

Sources for WWP1 Gene

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