Aliases for WWP1 Gene
External Ids for WWP1 Gene
Previous GeneCards Identifiers for WWP1 Gene
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]
GeneCards Summary for WWP1 Gene
WWP1 (WW Domain Containing E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Diseases associated with WWP1 include Troyer Syndrome. Among its related pathways are SMAD Signaling Network and TGF-beta receptor signaling (Pathway Interaction Database). GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is WWP2.
UniProtKB/Swiss-Prot for WWP1 Gene
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.