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Aliases for WWC3 Gene

Aliases for WWC3 Gene

  • WWC Family Member 3 2 3 5
  • KIAA1280 4
  • BM042 3

External Ids for WWC3 Gene

Previous GeneCards Identifiers for WWC3 Gene

  • GC0XP009943
  • GC0XP007861

Summaries for WWC3 Gene

Entrez Gene Summary for WWC3 Gene

  • This gene encodes a member of the WWC family of proteins, which also includes the WWC1 (KIBRA) gene product and the WWC2 gene product. The protein encoded by this gene includes a C2 domain, which is known to mediate homodimerization in the related WWC1 gene product. [provided by RefSeq, Sep 2011]

GeneCards Summary for WWC3 Gene

WWC3 (WWC Family Member 3) is a Protein Coding gene. GO annotations related to this gene include kinase binding and protein complex scaffold. An important paralog of this gene is WWC1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WWC3 Gene

Genomics for WWC3 Gene

Regulatory Elements for WWC3 Gene

Enhancers for WWC3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WWC3 on UCSC Golden Path with GeneCards custom track

Promoters for WWC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WWC3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the WWC3 gene promoter:

Genomic Location for WWC3 Gene

Chromosome:
X
Start:
10,015,562 bp from pter
End:
10,144,478 bp from pter
Size:
128,917 bases
Orientation:
Plus strand

Genomic View for WWC3 Gene

Genes around WWC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WWC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WWC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WWC3 Gene

Proteins for WWC3 Gene

  • Protein details for WWC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULE0-WWC3_HUMAN
    Recommended name:
    Protein WWC3
    Protein Accession:
    Q9ULE0
    Secondary Accessions:
    • A8KA96
    • Q659C1
    • Q9BTQ1

    Protein attributes for WWC3 Gene

    Size:
    1092 amino acids
    Molecular mass:
    122676 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WWC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WWC3 Gene

Proteomics data for WWC3 Gene at MOPED

Post-translational modifications for WWC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WWC3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WWC3 Gene

Domains & Families for WWC3 Gene

Protein Domains for WWC3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for WWC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULE0

UniProtKB/Swiss-Prot:

WWC3_HUMAN :
  • Contains 1 C2 domain.
  • Belongs to the WWC family.
Domain:
  • Contains 1 C2 domain.
Family:
  • Belongs to the WWC family.
genes like me logo Genes that share domains with WWC3: view

No data available for Gene Families for WWC3 Gene

Function for WWC3 Gene

Gene Ontology (GO) - Molecular Function for WWC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0032947 protein complex scaffold IDA 24682284
genes like me logo Genes that share ontologies with WWC3: view
genes like me logo Genes that share phenotypes with WWC3: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WWC3 Gene

Localization for WWC3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WWC3 Gene COMPARTMENTS Subcellular localization image for WWC3 gene
Compartment Confidence
cytosol 5
nucleus 3
cytoskeleton 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WWC3 Gene

Pathways & Interactions for WWC3 Gene

SuperPathways for WWC3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WWC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 24682284
genes like me logo Genes that share ontologies with WWC3: view

No data available for Pathways by source and SIGNOR curated interactions for WWC3 Gene

Drugs & Compounds for WWC3 Gene

No Compound Related Data Available

Transcripts for WWC3 Gene

mRNA/cDNA for WWC3 Gene

Unigene Clusters for WWC3 Gene

WWC family member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WWC3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ·
SP1: - - - - -
SP2: - -
SP3: -
SP4: - -
SP5:
SP6: - -
SP7:
SP8:

ExUns: 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for WWC3 Gene

GeneLoc Exon Structure for
WWC3
ECgene alternative splicing isoforms for
WWC3

Expression for WWC3 Gene

mRNA expression in normal human tissues for WWC3 Gene

Protein differential expression in normal tissues from HIPED for WWC3 Gene

This gene is overexpressed in Liver (23.5), Plasma (23.3), and Placenta (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WWC3 Gene



SOURCE GeneReport for Unigene cluster for WWC3 Gene Hs.527524

genes like me logo Genes that share expression patterns with WWC3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for WWC3 Gene

Orthologs for WWC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for WWC3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WWC3 35
  • 82.89 (n)
  • 84.73 (a)
WWC3 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WWC3 35
  • 84.88 (n)
  • 85.83 (a)
WWC3 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WWC3 35
  • 97.43 (n)
  • 97.12 (a)
WWC3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wwc3 35
  • 81.76 (n)
  • 85.03 (a)
oppossum
(Monodelphis domestica)
Mammalia WWC3 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
chicken
(Gallus gallus)
Aves WWC3 35
  • 73.74 (n)
  • 80.61 (a)
WWC3 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WWC3 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wwc3 35
  • 68.61 (n)
  • 70.89 (a)
zebrafish
(Danio rerio)
Actinopterygii wwc3 35
  • 61.79 (n)
  • 58.46 (a)
wwc3 36
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta kibra 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5313 36
  • 13 (a)
ManyToMany
CSA.8937 36
  • 19 (a)
ManyToMany
Species with no ortholog for WWC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WWC3 Gene

ENSEMBL:
Gene Tree for WWC3 (if available)
TreeFam:
Gene Tree for WWC3 (if available)

Paralogs for WWC3 Gene

Paralogs for WWC3 Gene

(2) SIMAP similar genes for WWC3 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for WWC3 Gene

genes like me logo Genes that share paralogs with WWC3: view

Variants for WWC3 Gene

Sequence variations from dbSNP and Humsavar for WWC3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs5934750 - 10,117,542(+) TGGGC(A/G)CCCTA reference, missense
rs36076296 - 10,124,291(+) TGCCT(A/G)CGGAG reference, missense
rs55787431 - 10,130,015(+) CCCTC(A/C/T)GTACC reference, missense
rs747676344 -- 10,120,310(+) AATCA(A/G)AACCT intron-variant
rs747678759 -- 10,142,339(+) CCGAC(C/T)GTAAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for WWC3 Gene

Variant ID Type Subtype PubMed ID
esv25793 CNV Loss 19812545
nsv425073 CNV Insertion 16902084
dgv2438e1 CNV Complex 17122850
nsv524562 CNV Gain 19592680
nsv425191 CNV Loss 16902084

Variation tolerance for WWC3 Gene

Residual Variation Intolerance Score: 88.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.93; 49.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WWC3 Gene

Human Gene Mutation Database (HGMD)
WWC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WWC3 Gene

Disorders for WWC3 Gene

Relevant External Links for WWC3

Genetic Association Database (GAD)
WWC3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WWC3

No disorders were found for WWC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WWC3 Gene

Publications for WWC3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 67
  2. Evolutionary and Molecular Facts Link the WWC Protein Family to Hippo Signaling. (PMID: 24682284) Wennmann D.O. … Kremerskothen J. (Mol. Biol. Evol. 2014) 3
  3. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for WWC3 Gene

Sources for WWC3 Gene

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