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Aliases for WWC3 Gene

Aliases for WWC3 Gene

  • WWC Family Member 3 2 3
  • Protein WWC3 3
  • KIAA1280 4
  • BM042 3

External Ids for WWC3 Gene

Summaries for WWC3 Gene

Entrez Gene Summary for WWC3 Gene

  • This gene encodes a member of the WWC family of proteins, which also includes the WWC1 (KIBRA) gene product and the WWC2 gene product. The protein encoded by this gene includes a C2 domain, which is known to mediate homodimerization in the related WWC1 gene product. [provided by RefSeq, Sep 2011]

GeneCards Summary for WWC3 Gene

WWC3 (WWC Family Member 3) is a Protein Coding gene. An important paralog of this gene is WWC1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WWC3 Gene

Genomics for WWC3 Gene

Genomic Location for WWC3 Gene

Start:
10,015,562 bp from pter
End:
10,144,478 bp from pter
Size:
128,917 bases
Orientation:
Plus strand

Genomic View for WWC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WWC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WWC3 Gene

Regulatory Elements for WWC3 Gene

Transcription factor binding sites by QIAGEN in the WWC3 gene promoter:

Proteins for WWC3 Gene

  • Protein details for WWC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULE0-WWC3_HUMAN
    Recommended name:
    Protein WWC3
    Protein Accession:
    Q9ULE0
    Secondary Accessions:
    • A8KA96
    • Q659C1
    • Q9BTQ1

    Protein attributes for WWC3 Gene

    Size:
    1092 amino acids
    Molecular mass:
    122676 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WWC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WWC3 Gene

Proteomics data for WWC3 Gene at MOPED

Post-translational modifications for WWC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WWC3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WWC3 Gene

Domains for WWC3 Gene

Gene Families for WWC3 Gene

HGNC:
  • WWC :WW, C2 and coiled-coil domain containing

Protein Domains for WWC3 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

WWC3_HUMAN
Domain:
  • Contains 1 C2 domain.:
    • Q9ULE0
Family:
  • Belongs to the WWC family.:
    • Q9ULE0
genes like me logo Genes that share domains with WWC3: view

Function for WWC3 Gene

Gene Ontology (GO) - Molecular Function for WWC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0019900 kinase binding IPI 24682284
GO:0032947 protein complex scaffold IDA 24682284
genes like me logo Genes that share ontologies with WWC3: view

miRNA for WWC3 Gene

miRTarBase miRNAs that target WWC3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for WWC3 Gene

Localization for WWC3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WWC3 Gene COMPARTMENTS Subcellular localization image for WWC3 gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for WWC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 24682284
genes like me logo Genes that share ontologies with WWC3: view

Pathways for WWC3 Gene

SuperPathways for WWC3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WWC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 24682284
GO:0035331 negative regulation of hippo signaling IDA 24682284
GO:0046621 negative regulation of organ growth IMP 24682284
genes like me logo Genes that share ontologies with WWC3: view

No data available for Pathways by source for WWC3 Gene

Transcripts for WWC3 Gene

mRNA/cDNA for WWC3 Gene

Unigene Clusters for WWC3 Gene

WWC family member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WWC3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ·
SP1: - - - - -
SP2: - -
SP3: -
SP4: - -
SP5:
SP6: - -
SP7:
SP8:

ExUns: 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for WWC3 Gene

GeneLoc Exon Structure for
WWC3
ECgene alternative splicing isoforms for
WWC3

Expression for WWC3 Gene

mRNA expression in normal human tissues for WWC3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for WWC3 Gene

SOURCE GeneReport for Unigene cluster for WWC3 Gene Hs.527524

genes like me logo Genes that share expressions with WWC3: view

Orthologs for WWC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for WWC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WWC3 36
  • 97.43 (n)
  • 97.12 (a)
WWC3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WWC3 36
  • 82.89 (n)
  • 84.73 (a)
WWC3 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WWC3 36
  • 84.88 (n)
  • 85.83 (a)
WWC3 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WWC3 37
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 82 (a)
OneToMany
-- 37
  • 76 (a)
OneToMany
-- 37
  • 95 (a)
OneToMany
-- 37
  • 76 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Wwc3 36
  • 81.76 (n)
  • 85.03 (a)
chicken
(Gallus gallus)
Aves WWC3 36
  • 73.74 (n)
  • 80.61 (a)
WWC3 37
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WWC3 37
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wwc3 36
  • 68.61 (n)
  • 70.89 (a)
zebrafish
(Danio rerio)
Actinopterygii wwc3 36
  • 61.79 (n)
  • 58.46 (a)
wwc3 37
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta kibra 37
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5313 37
  • 13 (a)
ManyToMany
CSA.8937 37
  • 19 (a)
ManyToMany
Species with no ortholog for WWC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WWC3 Gene

ENSEMBL:
Gene Tree for WWC3 (if available)
TreeFam:
Gene Tree for WWC3 (if available)

Paralogs for WWC3 Gene

Paralogs for WWC3 Gene

Selected SIMAP similar genes for WWC3 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for WWC3 Gene

genes like me logo Genes that share paralogs with WWC3: view

Variants for WWC3 Gene

Sequence variations from dbSNP and Humsavar for WWC3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs7545 -- 10,144,162(-) TTATC(C/G)CGAGG utr-variant-3-prime
rs7995 -- 10,144,298(+) CTAAT(A/C)ACTGA utr-variant-3-prime
rs719143 -- 10,061,916(-) GTGCA(G/T)TGGCT intron-variant
rs728141 -- 10,052,687(+) GGAAG(G/T)ACAAA intron-variant
rs735229 -- 10,106,776(-) CAAGG(G/T)CATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WWC3 Gene

Variant ID Type Subtype PubMed ID
esv25793 CNV Loss 19812545
nsv425073 CNV Insertion 16902084
dgv2438e1 CNV Complex 17122850
nsv524562 CNV Gain 19592680
nsv425191 CNV Loss 16902084

Relevant External Links for WWC3 Gene

HapMap Linkage Disequilibrium report
WWC3
Human Gene Mutation Database (HGMD)
WWC3
Locus Specific Mutation Databases (LSDB)
WWC3

Disorders for WWC3 Gene

Relevant External Links for WWC3

Genetic Association Database (GAD)
WWC3
genes like me logo Genes that share disorders with WWC3: view

No data available for UniProtKB/Swiss-Prot for WWC3 Gene

Publications for WWC3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for WWC3 Gene

Sources for WWC3 Gene

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