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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WWC2 Gene

protein-coding   GIFtS: 46
GCID: GC04P184020

WW and C2 domain containing 2

(Previous names: WW, C2 and coiled-coil domain containing 2 )
 Explore 3 diseases affiliated with
WWC2 via our new
 Human Malady Compendium 
Biological research products
for WWC2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
WW And C2 Domain Containing 21 2     WW Domain-Containing Protein 22 3
BOMB1 2 3     FLJ220291
WW, C2 And Coiled-Coil Domain Containing 21 2     BH3-Only Member B Protein2
BH-3-Only Member B2 3     Protein WWC22

External Ids:    HGNC: 241481   Entrez Gene: 800142   Ensembl: ENSG000001517187   UniProtKB: Q6AWC23   

Export aliases for WWC2 gene to outside databases

Previous GC identifers: GC04P184351 GC04P179780


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WWC2 gene promoter:
         AML1a   Pbx1a   FOXD3   Lmo2   Olf-1   AP-2alpha isoform 2   HEN1   AP-2alpha isoform 4   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWWC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for WWC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WWC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q35.1   Ensembl cytogenetic band:  4q35.1   HGNC cytogenetic band: 4q35.1

WWC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WWC2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P184020:  view genomic region     (about GC identifiers)

Start:
184,020,446 bp from pter      End:
184,241,930 bp from pter
Size:
221,485 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: WWC2_HUMAN, Q6AWC2 (See protein sequence)
Recommended Name: Protein WWC2  
Size: 1192 amino acids; 133891 Da
Sequence caution: Sequence=AAH17957.1; Type=Erroneous initiation; Sequence=AAI07684.1; Type=Miscellaneous discrepancy;
Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAB15215.1; Type=Erroneous initiation;
Sequence=BAB85032.1; Type=Erroneous initiation; Sequence=CAD97477.1; Type=Erroneous initiation;
Secondary accessions: Q32Q84 Q69YQ1 Q6AWB8 Q6ZSY9 Q6ZU09 Q7Z620 Q8TEB8 Q9H6P0
Alternative splicing: 7 isoforms:  Q6AWC2-1   Q6AWC2-2   Q6AWC2-3   Q6AWC2-4   Q6AWC2-5   Q6AWC2-6   Q6AWC2-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WWC2: NX_Q6AWC2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6AWC2

  • WWC2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_079225.5  
    ENSEMBL proteins: 
     ENSP00000384222   ENSP00000423238   ENSP00000425054   ENSP00000398577   ENSP00000393342  
     ENSP00000413521   ENSP00000427569   ENSP00000420835   ENSP00000368205  

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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    WWC2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR001202 WW_Rsp5_WWP

    Graphical View of Domain Structure for InterPro Entry Q6AWC2

    ProtoNet protein and cluster: Q6AWC2

    1 Blocks protein family: IPB000008 C2 domain

    UniProtKB/Swiss-Prot: WWC2_HUMAN, Q6AWC2
    Similarity: Belongs to the WWC family
    Similarity: Contains 1 C2 domain
    Similarity: Contains 2 WW domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    3 GenomeRNAi human phenotypes for WWC2:
     Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WWC2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/7 Interacting proteins for WWC2 (Q6AWC22, 3 ENSP000003842224) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3MINT-3318285 I2D: score=1 
    RUVBL1Q9Y2653, ENSP000003182974I2D: score=1 STRING: ENSP00000318297
    YWHAQP273483, ENSP000002380814I2D: score=1 STRING: ENSP00000238081
    PAHP004393I2D: score=5 
    SMARCD1Q96GM53I2D: score=5 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for WWC2
    Search CenterWatch for drugs/clinical trials and news about WWC2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WWC2 gene: 
    NM_024949.5  

    Unigene Cluster for WWC2:

    WW and C2 domain containing 2
    Hs.333179  [show with all ESTs]
    Unigene Representative Sequence: NM_024949
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000403733(uc010irx.3 uc003ivk.4 uc003ivl.4 uc010iry.3 uc003ivn.4 uc010irz.3 uc003ivo.4)
    ENST00000508614 ENST00000513834 ENST00000448232 ENST00000427431 ENST00000438543
    ENST00000504005 ENST00000506225 ENST00000515284 ENST00000508747 ENST00000378925


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    hsa-miR-579 hsa-miR-300 hsa-miR-4272 hsa-miR-106a hsa-miR-146a hsa-miR-374a hsa-miR-519a hsa-miR-93
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    OriGene shRNA RFP: WWC2
    OriGene siRNA: WWC2
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    Additional cDNA sequence: 

    AJ566366.1 AK025682.1 AK074260.1 AK091401.1 AK127061.1 AK225323.1 AL832424.1 BC017957.1 
    BC053873.1 BC107683.1 BX647378.1 BX647704.1 

    11 DOTS entries:

    DT.100776397  DT.442412  DT.97840139  DT.99987517  DT.40208327  DT.100776399  DT.86843525  DT.91849279 
    DT.86836568  DT.95100702  DT.121217786 

    24/120 AceView cDNA sequences (see all 120):

    AA774954 BQ029441 AI569345 BF512875 BC053873 AI341277 BG034470 AW589643 
    AW517719 AW303614 F09729 BX505400 BM670729 BC017957 BU552462 BM471272 
    BG566150 CA446513 CB143347 BX505401 AK127061 AV681710 AL832424 BM473522 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for WWC2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                                                                                
    SP2:                                                                                                
    SP3:        -     -     -                                                                           
    SP4:                                                                                                


    ECgene alternative splicing isoforms for WWC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WWC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTCTGTTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See WWC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WWC2

    SOURCE GeneReport for Unigene cluster: Hs.333179
        SABiosciences Custom PCR Arrays for WWC2
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for WWC2 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves WWC21 WW and C2 domain containing 2 76.13(n)
    78.01(a)
      422555  XM_420516.3  XP_420516.3 
    lizard
    (Anolis carolinensis)
    Reptilia WWC26
    --
    75(a)
    1 ↔ 1
    5(113903197-114012338)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX725736.12   -- 76.67(n)    BX725736.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta kibra6
    kibra ortholog
    27(a)
    1 → many
    3R(10524252-10549978)


    ENSEMBL Gene Tree for WWC2 (if available)
    TreeFam Gene Tree for WWC2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WWC2 gene
    WWC12  WWC32  
    10 SIMAP similar genes for WWC2 using alignment to 3 protein entries:     WWC2_HUMAN (see all proteins):
    WWC1    YAP1    MAGI2    WWC3    NEDD4L    YAP
    MAGI1    PLEKHA7    WWOX    SMURF2

    WWC2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for WWC2
    PGOHUM00000251341


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for WWC2
         2 CNVs: 68860 64052
         4 Indels: 27542 60505 12597 60504
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    WWC2 for disorders           About GeneDecksing

    3 diseases for WWC2:    About MalaCards
    acute lymphocytic leukemia    lymphocytic leukemia    leukemia

    Human Genome Epidemiology (HuGE) Navigator: WWC2 (3 documents)

    Export disorders for WWC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WWC2 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with WWC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. PTPN14 is required for the density-dependent control of YAP1. (PubMed id 22948661)1 Wang W....Chen J. (2012)
    4. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    6. Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)1 Lango Allen H....Hirschhorn J.N. (2010)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    8. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80014 HGNC: 24148 AceView: BOMB Ensembl:ENSG00000151718 euGenes: HUgn80014
    ECgene: WWC2 H-InvDB: WWC2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WWC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WWC2 gene:
    Search GeneIP for patents involving WWC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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