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Aliases for WWC2 Gene

Aliases for WWC2 Gene

  • WW And C2 Domain Containing 2 2 3
  • WW, C2 And Coiled-Coil Domain Containing 2 2 3
  • WW Domain-Containing Protein 2 3 4
  • BH-3-Only Member B 3 4
  • BOMB 3 4
  • BH3-Only Member B Protein 3
  • Protein WWC2 3

External Ids for WWC2 Gene

Previous GeneCards Identifiers for WWC2 Gene

  • GC04P184351
  • GC04P184020
  • GC04P179780

Summaries for WWC2 Gene

GeneCards Summary for WWC2 Gene

WWC2 (WW And C2 Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is WWC1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WWC2 Gene

Genomics for WWC2 Gene

Regulatory Elements for WWC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WWC2 Gene

183,099,273 bp from pter
183,320,777 bp from pter
221,505 bases
Plus strand

Genomic View for WWC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WWC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WWC2 Gene

Proteins for WWC2 Gene

  • Protein details for WWC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein WWC2
    Protein Accession:
    Secondary Accessions:
    • Q32Q84
    • Q69YQ1
    • Q6AWB8
    • Q6ZSY9
    • Q6ZU09
    • Q7Z620
    • Q8TEB8
    • Q9H6P0

    Protein attributes for WWC2 Gene

    1192 amino acids
    Molecular mass:
    133891 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH17957.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI07684.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB15215.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB85032.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD97477.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for WWC2 Gene

neXtProt entry for WWC2 Gene

Proteomics data for WWC2 Gene at MOPED

Post-translational modifications for WWC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WWC2 Gene

Domains for WWC2 Gene

Gene Families for WWC2 Gene

Protein Domains for WWC2 Gene


Suggested Antigen Peptide Sequences for WWC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C2 domain.
  • Belongs to the WWC family.
  • Contains 1 C2 domain.
  • Contains 2 WW domains.
  • Belongs to the WWC family.
genes like me logo Genes that share domains with WWC2: view

Function for WWC2 Gene

Gene Ontology (GO) - Molecular Function for WWC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0019900 kinase binding IPI 24682284
GO:0032947 protein complex scaffold IDA 24682284
genes like me logo Genes that share ontologies with WWC2: view

Phenotypes for WWC2 Gene

genes like me logo Genes that share phenotypes with WWC2: view

Animal Model Products

miRNA for WWC2 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WWC2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for WWC2 Gene

Localization for WWC2 Gene

Subcellular locations from

Jensen Localization Image for WWC2 Gene COMPARTMENTS Subcellular localization image for WWC2 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for WWC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 24682284
genes like me logo Genes that share ontologies with WWC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WWC2 Gene

Pathways for WWC2 Gene

SuperPathways for WWC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WWC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 24682284
GO:0035331 negative regulation of hippo signaling IDA 24682284
GO:0046621 negative regulation of organ growth IMP 24682284
genes like me logo Genes that share ontologies with WWC2: view

No data available for Pathways by source for WWC2 Gene

Transcripts for WWC2 Gene

Unigene Clusters for WWC2 Gene

WW and C2 domain containing 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WWC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WWC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP3: - - -

Relevant External Links for WWC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WWC2 Gene

mRNA expression in normal human tissues for WWC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for WWC2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (25.7) and Testis (18.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WWC2 Gene

SOURCE GeneReport for Unigene cluster for WWC2 Gene Hs.333179

genes like me logo Genes that share expressions with WWC2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for WWC2 Gene

Orthologs for WWC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for WWC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WWC2 35
  • 82.6 (n)
  • 86.28 (a)
WWC2 36
  • 85 (a)
(Canis familiaris)
Mammalia WWC2 35
  • 87.08 (n)
  • 90.42 (a)
WWC2 36
  • 89 (a)
(Mus musculus)
Mammalia Wwc2 35
  • 83.32 (n)
  • 87.15 (a)
Wwc2 16
Wwc2 36
  • 86 (a)
(Pan troglodytes)
Mammalia WWC2 35
  • 99.08 (n)
  • 98.74 (a)
WWC2 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Wwc2 35
  • 83.67 (n)
  • 87.65 (a)
(Monodelphis domestica)
Mammalia WWC2 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
(Gallus gallus)
Aves WWC2 35
  • 76.11 (n)
  • 78.04 (a)
WWC2 36
  • 76 (a)
(Anolis carolinensis)
Reptilia WWC2 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC79698 35
  • 69.35 (n)
  • 72.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta kibra 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5313 36
  • 62 (a)
CSA.8937 36
  • 22 (a)
Species with no ortholog for WWC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for WWC2 Gene

Gene Tree for WWC2 (if available)
Gene Tree for WWC2 (if available)

Paralogs for WWC2 Gene

Paralogs for WWC2 Gene

(8) SIMAP similar genes for WWC2 Gene using alignment to 3 proteins: Pseudogenes for WWC2 Gene

genes like me logo Genes that share paralogs with WWC2: view

Variants for WWC2 Gene

Sequence variations from dbSNP and Humsavar for WWC2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs882998 -- 183,255,358(-) ACAAA(C/T)TAATT intron-variant
rs907357 -- 183,248,872(+) TATCT(A/G)TGCTG intron-variant
rs907358 -- 183,255,406(+) CCTGA(G/T)GTGTC intron-variant
rs907360 -- 183,313,434(-) CAGCC(A/G)CTGCC intron-variant
rs907361 -- 183,230,032(-) GCTTA(C/G)GCAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WWC2 Gene

Variant ID Type Subtype PubMed ID
nsv822872 CNV Gain 20364138
esv26194 CNV Loss 19812545
nsv4629 CNV Loss 18451855
esv2728858 CNV Deletion 23290073
esv2728859 CNV Deletion 23290073
nsv292991 CNV Loss 16902084
esv1447400 CNV Deletion 17803354
nsv290254 CNV Loss 16902084
esv2671317 CNV Deletion 23128226
esv8514 CNV Gain 19470904
esv2661293 CNV Deletion 23128226
esv21553 CNV Loss 19812545
nsv507223 CNV Insertion 20534489
esv6918 CNV Gain 19470904
nsv528100 CNV Gain 19592680

Relevant External Links for WWC2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WWC2 Gene

Disorders for WWC2 Gene

Relevant External Links for WWC2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for WWC2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for WWC2 Gene

Publications for WWC2 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins. (PMID: 15161933) Meek S.E. … Piwnica-Worms H. (J. Biol. Chem. 2004) 3
  5. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PMID: 15302935) Beausoleil S.A. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3

Products for WWC2 Gene

Sources for WWC2 Gene

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