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WWC2 Gene

protein-coding   GIFtS: 51
GCID: GC04P184020

WW And C2 Domain Containing 2

(Previous names: WW, C2 and coiled-coil domain containing 2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WW And C2 Domain Containing 21 2     WW Domain-Containing Protein 22 3
WW, C2 And Coiled-Coil Domain Containing 21 2     BH3-Only Member B Protein2
BOMB2 3     Protein WWC22
BH-3-Only Member B2 3     

External Ids:    HGNC: 241481   Entrez Gene: 800142   Ensembl: ENSG000001517187   UniProtKB: Q6AWC23   

Export aliases for WWC2 gene to outside databases

Previous GC identifers: GC04P184351 GC04P179780


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for WWC2 Gene:
WWC2 (WW and C2 domain containing 2) is a protein-coding gene. Diseases associated with WWC2 include acute lymphocytic leukemia, and leukemia. An important paralog of this gene is WWC1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WWC2 gene promoter:
         AML1a   Pbx1a   FOXD3   Lmo2   Olf-1   AP-2alpha isoform 2   HEN1   AP-2alpha isoform 4   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWWC2 promoter sequence
   Search Chromatin IP Primers for WWC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WWC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q35.1   Ensembl cytogenetic band:  4q35.1   HGNC cytogenetic band: 4q35.1

WWC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WWC2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P184020:  view genomic region     (about GC identifiers)

Start:
184,020,446 bp from pter      End:
184,241,930 bp from pter
Size:
221,485 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: WWC2_HUMAN, Q6AWC2 (See protein sequence)
Recommended Name: Protein WWC2  
Size: 1192 amino acids; 133891 Da
Sequence caution: Sequence=AAH17957.1; Type=Erroneous initiation; Sequence=AAI07684.1; Type=Miscellaneous
discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAB15215.1; Type=Erroneous
initiation; Sequence=BAB85032.1; Type=Erroneous initiation; Sequence=CAD97477.1; Type=Erroneous initiation;
Secondary accessions: Q32Q84 Q69YQ1 Q6AWB8 Q6ZSY9 Q6ZU09 Q7Z620 Q8TEB8 Q9H6P0
Alternative splicing: 7 isoforms:  Q6AWC2-1   Q6AWC2-2   Q6AWC2-3   Q6AWC2-4   Q6AWC2-5   Q6AWC2-6   Q6AWC2-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WWC2: NX_Q6AWC2

Explore proteomics data for WWC2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See WWC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079225.5  
    ENSEMBL proteins: 
     ENSP00000384222   ENSP00000423238   ENSP00000425054   ENSP00000398577   ENSP00000393342  
     ENSP00000413521   ENSP00000427569   ENSP00000420835   ENSP00000368205  

    WWC2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals WWC2 Protein
    Novus Biologicals WWC2 Lysate
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    Cloud-Clone Corp. Proteins for WWC2

    WWC2 Antibody Products:

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    Abcam antibodies for WWC2
    Cloud-Clone Corp. Antibodies for WWC2
    Search ThermoFisher Antibodies for WWC2
    LSBio Antibodies in human, mouse, rat for WWC2

    WWC2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for WWC2
    Cloud-Clone Corp. CLIAs for WWC2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WWC: WW, C2 and coiled-coil domain containing

    2 InterPro protein domains:
     IPR001202 WW_dom
     IPR000008 C2_dom

    Graphical View of Domain Structure for InterPro Entry Q6AWC2

    ProtoNet protein and cluster: Q6AWC2

    1 Blocks protein domain: IPB000008 C2 domain

    UniProtKB/Swiss-Prot: WWC2_HUMAN, Q6AWC2
    Similarity: Belongs to the WWC family
    Similarity: Contains 1 C2 domain
    Similarity: Contains 2 WW domains


    WWC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    WWC2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for WWC2:
     Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WWC2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for WWC2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WWC2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WWC2

    miRNA
    Products:
        
    miRTarBase miRNAs that target WWC2:
    hsa-mir-21-5p (MIRT031068), hsa-mir-375 (MIRT020064), hsa-mir-192-5p (MIRT026951), hsa-mir-215-5p (MIRT024576)

    Block miRNA regulation of human, mouse, rat WWC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WWC2 (see all 75):
    hsa-miR-579 hsa-miR-300 hsa-miR-4272 hsa-miR-106a hsa-miR-146a hsa-miR-374a hsa-miR-519a hsa-miR-93
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for WWC2
    Predesigned siRNA for gene silencing in human, mouse, rat WWC2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for WWC2

    Clone
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    OriGene clones in human, mouse for WWC2 (see all 9)
    OriGene ORF clones in mouse, rat for WWC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WWC2 (NM_024949)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WWC2
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat WWC2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for WWC2
    Browse ESI BIO Cell Lines and PureStem Progenitors for WWC2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WWC2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    cytoskeleton1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WWC2
    Interactions:

        Search GeneGlobe Interaction Network for WWC2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for WWC2 (Q6AWC22, 3 ENSP000003842224) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3MINT-3318285 I2D: score=1 
    RUVBL1Q9Y2653, ENSP000003182974I2D: score=1 STRING: ENSP00000318297
    YWHAQP273483, ENSP000002380814I2D: score=1 STRING: ENSP00000238081
    PAHP004393I2D: score=5 
    SMARCD1Q96GM53I2D: score=5 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WWC2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for WWC2 gene: 
    NM_024949.5  

    Unigene Cluster for WWC2:

    WW and C2 domain containing 2
    Hs.333179  [show with all ESTs]
    Unigene Representative Sequence: NM_024949
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000403733(uc010irx.3 uc003ivk.4 uc003ivl.4 uc010iry.3 uc003ivn.4 uc010irz.3 uc003ivo.4)
    ENST00000508614 ENST00000513834 ENST00000448232 ENST00000427431 ENST00000438543
    ENST00000504005 ENST00000506225 ENST00000515284 ENST00000508747 ENST00000378925

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat WWC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WWC2 (see all 75):
    hsa-miR-579 hsa-miR-300 hsa-miR-4272 hsa-miR-106a hsa-miR-146a hsa-miR-374a hsa-miR-519a hsa-miR-93
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for WWC2
    Predesigned siRNA for gene silencing in human, mouse, rat WWC2
    Clone
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    OriGene clones in human, mouse for WWC2 (see all 9)
    OriGene ORF clones in mouse, rat for WWC2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WWC2 (NM_024949)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WWC2
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat WWC2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for WWC2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WWC2
      QuantiTect SYBR Green Assays in human, mouse, rat WWC2
      QuantiFast Probe-based Assays in human, mouse, rat WWC2

    Additional mRNA sequence: 

    AJ566366.1 AK025682.1 AK074260.1 AK091401.1 AK127061.1 AK225323.1 AK303864.1 AL832424.1 
    BC017957.1 BC053873.1 BC107683.1 BX647378.1 BX647704.1 

    11 DOTS entries:

    DT.100776397  DT.442412  DT.97840139  DT.99987517  DT.40208327  DT.100776399  DT.86843525  DT.91849279 
    DT.86836568  DT.95100702  DT.121217786 

    Selected AceView cDNA sequences (see all 120):

    AA774954 CB143347 BF512875 AI569345 BG034470 AW303614 AK127061 BC053873 
    BX505400 AW517719 AV681710 BM473522 AW195363 BU552462 AW589643 CA429789 
    CA446513 BG566150 BQ029441 BM471272 AI341277 BX505401 BC017957 BM670729 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for WWC2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                                                                                
    SP2:                                                                                                
    SP3:        -     -     -                                                                           
    SP4:                                                                                                


    ECgene alternative splicing isoforms for WWC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WWC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCTGTTTT
    WWC2 Expression
    About this image


    WWC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
    WWC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WWC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.333179
        Custom PCR Arrays for WWC2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for WWC2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WWC2
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    QuantiFast Probe-based Assays in human, mouse, rat WWC2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WWC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WWC2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wwc21 , 5 WW, C2 and coiled-coil domain containing 21, 5 83.32(n)1
    87.15(a)1
      8 (26.91 cM)5
    523571  NM_133791.41  NP_598552.21 
     478275955 
    chicken
    (Gallus gallus)
    Aves WWC21 WW and C2 domain containing 2 76.11(n)
    78.04(a)
      422555  XM_420516.4  XP_420516.4 
    lizard
    (Anolis carolinensis)
    Reptilia WWC26
    WW and C2 domain containing 2
    74(a)
    1 ↔ 1
    5(113903197-114094522)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX725736.12   -- 76.67(n)    BX725736.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta kibra6
    kibra ortholog
    28(a)
    1 → many
    3R(10524252-10549978)


    ENSEMBL Gene Tree for WWC2 (if available)
    TreeFam Gene Tree for WWC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WWC2 gene
    WWC12  WWC32  
    8 SIMAP similar genes for WWC2 using alignment to 3 protein entries:     WWC2_HUMAN (see all proteins):
    YAP1    WWC1    MAGI2    WWC3    NEDD4L    MAGI1
    PLEKHA7    WWOX

    WWC2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for WWC2
    PGOHUM00000251341


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WWC2 (see all 4546)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1461609431,2
    Cuntested1184182576(+) CTCATA/C/TGAAAA 2 I syn11NA 4534
    rs342810951,2
    C--179863129(+) TAATA-/CAGTGTA 1 -- int11Minor allele frequency- CA:0.00NA 2
    rs1831073181,2
    --184022463(+) ATGACC/TTGGCT 1 -- int10--------
    rs1887380261,2
    --184022521(+) AACTCC/TTAATG 1 -- int10--------
    rs1404335231,2
    C--184022570(+) TAAAC-/AATT  
            
    CATTG
    1 -- int10--------
    rs1153454401,2
    F--184022591(+) ACAAAT/GAGTTT 1 -- int11Minor allele frequency- G:0.01WA 118
    rs1929633761,2
    --184022661(+) CAGAGA/GCATAA 1 -- int10--------
    rs1852289121,2
    --184022812(+) AGTAAC/GAGCTG 1 -- int10--------
    rs347154901,2
    C,F,H--184022901(+) GTTACA/CCAGGC 1 -- int17Minor allele frequency- C:0.03NS NA 1264
    rs1389345481,2
    C--184022907(+) CAGGCC/TAATAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for WWC2 (184020446 - 184241930 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for WWC2 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1447400CNV Deletion17803354
    esv2661293CNV Deletion23128226
    esv2728858CNV Deletion23290073
    esv2671317CNV Deletion23128226
    esv2728859CNV Deletion23290073
    nsv507223CNV Insertion20534489
    esv21553CNV Loss19812545
    esv26194CNV Loss19812545
    nsv290254CNV Loss16902084
    nsv4629CNV Loss18451855

    Human Gene Mutation Database (HGMD): WWC2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WWC2
    DNA2.0 Custom Variant and Variant Library Synthesis for WWC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for WWC2:    
    About MalaCards
    acute lymphocytic leukemia    leukemia


    WWC2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): WWC2
    Human Genome Epidemiology (HuGE) Navigator: WWC2 (3 documents)

    Export disorders for WWC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WWC2 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with WWC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. PTPN14 is required for the density-dependent control of YAP1. (PubMed id 22948661)1 Wang W....Chen J. (Genes Dev. 2012)
    5. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    8. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PubMed id 20881960)1 Lango Allen H....Hirschhorn J.N. (Nature 2010)
    9. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    10. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80014 HGNC: 24148 AceView: BOMB Ensembl:ENSG00000151718 euGenes: HUgn80014
    ECgene: WWC2 H-InvDB: WWC2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for WWC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WWC2 gene:
    Search GeneIP for patents involving WWC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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