Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WWC2 Gene

Aliases for WWC2 Gene

  • WW And C2 Domain Containing 2 2 3 5
  • WW, C2 And Coiled-Coil Domain Containing 2 2 3
  • WW Domain-Containing Protein 2 3 4
  • BH-3-Only Member B 3 4
  • BOMB 3 4
  • BH3-Only Member B Protein 3

External Ids for WWC2 Gene

Previous GeneCards Identifiers for WWC2 Gene

  • GC04P184351
  • GC04P184020
  • GC04P179780

Summaries for WWC2 Gene

GeneCards Summary for WWC2 Gene

WWC2 (WW And C2 Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include kinase binding and protein complex scaffold. An important paralog of this gene is WWC1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WWC2 Gene

Genomics for WWC2 Gene

Regulatory Elements for WWC2 Gene

Enhancers for WWC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WWC2 on UCSC Golden Path with GeneCards custom track

Promoters for WWC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WWC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for WWC2 Gene

Chromosome:
4
Start:
183,098,635 bp from pter
End:
183,320,777 bp from pter
Size:
222,143 bases
Orientation:
Plus strand

Genomic View for WWC2 Gene

Genes around WWC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WWC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WWC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WWC2 Gene

Proteins for WWC2 Gene

  • Protein details for WWC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6AWC2-WWC2_HUMAN
    Recommended name:
    Protein WWC2
    Protein Accession:
    Q6AWC2
    Secondary Accessions:
    • Q32Q84
    • Q69YQ1
    • Q6AWB8
    • Q6ZSY9
    • Q6ZU09
    • Q7Z620
    • Q8TEB8
    • Q9H6P0

    Protein attributes for WWC2 Gene

    Size:
    1192 amino acids
    Molecular mass:
    133891 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH17957.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI07684.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB15215.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB85032.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD97477.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for WWC2 Gene

neXtProt entry for WWC2 Gene

Proteomics data for WWC2 Gene at MOPED

Post-translational modifications for WWC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WWC2 Gene

Domains & Families for WWC2 Gene

Gene Families for WWC2 Gene

Protein Domains for WWC2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for WWC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6AWC2

UniProtKB/Swiss-Prot:

WWC2_HUMAN :
  • Contains 1 C2 domain.
  • Belongs to the WWC family.
Domain:
  • Contains 1 C2 domain.
  • Contains 2 WW domains.
Family:
  • Belongs to the WWC family.
genes like me logo Genes that share domains with WWC2: view

Function for WWC2 Gene

Gene Ontology (GO) - Molecular Function for WWC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0032947 protein complex scaffold IDA 24682284
genes like me logo Genes that share ontologies with WWC2: view
genes like me logo Genes that share phenotypes with WWC2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WWC2 Gene

Localization for WWC2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WWC2 Gene COMPARTMENTS Subcellular localization image for WWC2 gene
Compartment Confidence
cytosol 5
nucleus 3
cytoskeleton 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WWC2 Gene

Pathways & Interactions for WWC2 Gene

SuperPathways for WWC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WWC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 24682284
genes like me logo Genes that share ontologies with WWC2: view

No data available for Pathways by source and SIGNOR curated interactions for WWC2 Gene

Drugs & Compounds for WWC2 Gene

No Compound Related Data Available

Transcripts for WWC2 Gene

Unigene Clusters for WWC2 Gene

WW and C2 domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WWC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1:
SP2:
SP3: - - -
SP4:

Relevant External Links for WWC2 Gene

GeneLoc Exon Structure for
WWC2
ECgene alternative splicing isoforms for
WWC2

Expression for WWC2 Gene

mRNA expression in normal human tissues for WWC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WWC2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (25.7) and Testis (18.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WWC2 Gene



SOURCE GeneReport for Unigene cluster for WWC2 Gene Hs.333179

genes like me logo Genes that share expression patterns with WWC2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for WWC2 Gene

Orthologs for WWC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for WWC2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WWC2 35
  • 82.6 (n)
  • 86.28 (a)
WWC2 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WWC2 35
  • 87.08 (n)
  • 90.42 (a)
WWC2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wwc2 35
  • 83.32 (n)
  • 87.15 (a)
Wwc2 16
Wwc2 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WWC2 35
  • 99.08 (n)
  • 98.74 (a)
WWC2 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wwc2 35
  • 83.67 (n)
  • 87.65 (a)
oppossum
(Monodelphis domestica)
Mammalia WWC2 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 54 (a)
ManyToMany
chicken
(Gallus gallus)
Aves WWC2 35
  • 76.11 (n)
  • 78.04 (a)
WWC2 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WWC2 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC79698 35
  • 69.35 (n)
  • 72.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta kibra 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5313 36
  • 62 (a)
ManyToMany
CSA.8937 36
  • 22 (a)
ManyToMany
Species with no ortholog for WWC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for WWC2 Gene

ENSEMBL:
Gene Tree for WWC2 (if available)
TreeFam:
Gene Tree for WWC2 (if available)

Paralogs for WWC2 Gene

Paralogs for WWC2 Gene

(8) SIMAP similar genes for WWC2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for WWC2 Gene

genes like me logo Genes that share paralogs with WWC2: view

Variants for WWC2 Gene

Sequence variations from dbSNP and Humsavar for WWC2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs11941467 - 183,269,080(+) GAGTC(A/G/T)CCATT reference, missense
rs11734376 - 183,271,125(+) GTGAG(G/T)TTTTC reference, missense
rs3814422 - 183,282,733(-) TTCAT(C/G)AGAGG reference, missense
rs4862155 - 183,315,715(+) TGCCA(A/G/T)CTGAT reference, missense
rs45470696 - 183,284,277(+) CAGTT(C/G/T)GCCCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for WWC2 Gene

Variant ID Type Subtype PubMed ID
nsv822872 CNV Gain 20364138
esv26194 CNV Loss 19812545
nsv4629 CNV Loss 18451855
esv2728858 CNV Deletion 23290073
esv2728859 CNV Deletion 23290073
nsv292991 CNV Loss 16902084
esv1447400 CNV Deletion 17803354
nsv290254 CNV Loss 16902084
esv2671317 CNV Deletion 23128226
esv8514 CNV Gain 19470904
esv2661293 CNV Deletion 23128226
esv21553 CNV Loss 19812545
nsv507223 CNV Insertion 20534489
esv6918 CNV Gain 19470904
nsv528100 CNV Gain 19592680

Variation tolerance for WWC2 Gene

Residual Variation Intolerance Score: 67.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.70; 89.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WWC2 Gene

Human Gene Mutation Database (HGMD)
WWC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WWC2 Gene

Disorders for WWC2 Gene

Relevant External Links for WWC2

Genetic Association Database (GAD)
WWC2
Human Genome Epidemiology (HuGE) Navigator
WWC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WWC2

No disorders were found for WWC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WWC2 Gene

Publications for WWC2 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  5. Evolutionary and Molecular Facts Link the WWC Protein Family to Hippo Signaling. (PMID: 24682284) Wennmann D.O. … Kremerskothen J. (Mol. Biol. Evol. 2014) 3

Products for WWC2 Gene

Sources for WWC2 Gene

Content