WWC2 Gene
protein-coding GIFtS: 46
GCID: GC04P184020
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WW and C2 domain containing 2(Previous names: WW, C2 and coiled-coil domain containing 2 )
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Aliases for WWC2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| WW And C2 Domain Containing 21 2 | | WW Domain-Containing Protein 22 3 | | BOMB1 2 3 | | FLJ220291 | | WW, C2 And Coiled-Coil Domain Containing 21 2 | | BH3-Only Member B Protein2 | | BH-3-Only Member B2 3 | | Protein WWC22 |
Export aliases for WWC2 gene to outside databasesPrevious GC identifers: GC04P184351 GC04P179780 |
Summaries for WWC2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| -- |
Genomic Views for WWC2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the WWC2 gene promoter: AML1a Pbx1a FOXD3 Lmo2 Olf-1 AP-2alpha isoform 2 HEN1 AP-2alpha isoform 4 AP-2alphaA Other transcription factors
Search SABiosciences Chromatin IP Primers for WWC2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WWC2 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q35.1 Ensembl cytogenetic band: 4q35.1 HGNC cytogenetic band: 4q35.1WWC2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P184020: view genomic region
(about GC identifiers)
Start:
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184,020,446 bp from pter |
End:
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184,241,930 bp from pter |
Size:
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221,485 bases |
Orientation:
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plus strand |
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Proteins for WWC2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: WWC2_HUMAN, Q6AWC2 (See
protein sequence)Recommended Name: Protein WWC2 Size: 1192 amino acids; 133891 Da
Sequence caution: Sequence=AAH17957.1; Type=Erroneous initiation; Sequence=AAI07684.1; Type=Miscellaneous discrepancy;Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAB15215.1; Type=Erroneous initiation;Sequence=BAB85032.1; Type=Erroneous initiation; Sequence=CAD97477.1; Type=Erroneous initiation;
Secondary accessions: Q32Q84 Q69YQ1 Q6AWB8 Q6ZSY9 Q6ZU09 Q7Z620 Q8TEB8 Q9H6P0Alternative splicing: 7 isoforms: Q6AWC2-1 Q6AWC2-2 Q6AWC2-3 Q6AWC2-4 Q6AWC2-5 Q6AWC2-6 Q6AWC2-7 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for WWC2: NX_Q6AWC2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6AWC2 WWC2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079225.5 ENSEMBL proteins: ENSP00000384222 ENSP00000423238 ENSP00000425054 ENSP00000398577 ENSP00000393342 ENSP00000413521 ENSP00000427569 ENSP00000420835 ENSP00000368205 Human Recombinant Protein Products:
WWC2 Antibody Products: Assay Products for WWC2: |
Protein
Domains / Families for WWC2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WWC2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6AWC2ProtoNet protein and cluster: Q6AWC2 1 Blocks protein family: IPB000008 C2 domain
UniProtKB/Swiss-Prot: WWC2_HUMAN, Q6AWC2Similarity: Belongs to the WWC familySimilarity: Contains 1 C2 domainSimilarity: Contains 2 WW domains |
Function for WWC2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WWC2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WWC2 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: WWC2 (NM_024949) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WWC2 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat WWC2  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WWC2 |
3 GenomeRNAi human phenotypes for WWC2:
|
Pathways & Interactions for WWC2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WWC2
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
 5/7 Interacting proteins for WWC2 (Q6AWC22, 3 ENSP000003842224) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
|
Drugs & Compounds for WWC2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for WWC2 Search CenterWatch for drugs/clinical trials and news about WWC2 
|
Transcripts for WWC2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for WWC2 gene: NM_024949.5 Unigene Cluster for WWC2: WW and C2 domain containing 2 Hs.333179 [show with all ESTs]Unigene Representative Sequence: NM_02494911 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000403733(uc010irx.3 uc003ivk.4 uc003ivl.4 uc010iry.3 uc003ivn.4 uc010irz.3 uc003ivo.4) ENST00000508614 ENST00000513834 ENST00000448232 ENST00000427431 ENST00000438543 ENST00000504005 ENST00000506225 ENST00000515284 ENST00000508747 ENST00000378925
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WWC2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WWC2 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: WWC2 (NM_024949) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WWC2 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat WWC2  |
Additional cDNA sequence: AJ566366.1 AK025682.1 AK074260.1 AK091401.1 AK127061.1 AK225323.1 AL832424.1 BC017957.1 BC053873.1 BC107683.1 BX647378.1 BX647704.1 11 DOTS entries: DT.100776397 DT.442412 DT.97840139 DT.99987517 DT.40208327 DT.100776399 DT.86843525 DT.91849279 DT.86836568 DT.95100702 DT.121217786 24/120 AceView cDNA sequences (see all 120): AA774954 BQ029441 AI569345 BF512875 BC053873 AI341277 BG034470 AW589643 AW517719 AW303614 F09729 BX505400 BM670729 BC017957 BU552462 BM471272 BG566150 CA446513 CB143347 BX505401 AK127061 AV681710 AL832424 BM473522 GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for WWC2 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for WWC2
|
Expression for WWC2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WWC2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TTTCTGTTTT
About this image See WWC2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for WWC2
SOURCE GeneReport for Unigene cluster: Hs.333179 SABiosciences Custom PCR Arrays for WWC2
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WWC2 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WWC2 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WWC2 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WWC2 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WWC2 |
Orthologs for WWC2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for WWC2 gene from 4/14 species (see all 14) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
WWC21 |
WW and C2 domain containing 2 |
76.13(n) 78.01(a) |
  |
422555 XM_420516.3 XP_420516.3 |
lizard (Anolis carolinensis) |
Reptilia |
WWC26 |
-- |
75(a) |
1 ↔ 1 |
5(113903197-114012338) |
tropical clawed frog (Xenopus tropicalis) |
Amphibia |
BX725736.12 |
-- |
76.67(n) |
  |
BX725736.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
kibra6 |
kibra ortholog |
27(a) |
1 → many |
3R(10524252-10549978) |
ENSEMBL Gene Tree for WWC2 (if available) TreeFam Gene Tree for WWC2 (if available)  |
Paralogs for WWC2 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for WWC2 gene
- WWC12 WWC32
10 SIMAP similar genes for WWC2 using alignment to 3 protein entries: WWC2_HUMAN (see all proteins):WWC1 YAP1 MAGI2 WWC3 NEDD4L YAP MAGI1 PLEKHA7 WWOX SMURF2
WWC2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for WWC2 PGOHUM00000251341
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Genomic Variants for WWC2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 6 variations for WWC2 2 CNVs: 68860 64052 4 Indels: 27542 60505 12597 60504 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WWC2 |
|
Disorders
/ Diseases for WWC2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WWC2 for disorders About GeneDecksing
3 diseases for WWC2: About MalaCardsacute lymphocytic leukemia lymphocytic leukemia leukemia Human Genome Epidemiology (HuGE) Navigator: WWC2 (3 documents) Export disorders for WWC2 gene to outside databases
|
Publications for WWC2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WWC2 gene, integrated from 9 sources (see all 14): (articles sorted by number of sources associating them with WWC2) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- PTPN14 is required for the density-dependent control of YAP1. (PubMed id 22948661)1 Wang W....Chen J. (2012)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)1 Lango Allen H....Hirschhorn J.N. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
|
External Searches for WWC2 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing WWC2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WWC2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WWC2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for WWC2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WWC2 gene: Search GeneIP for patents involving WWC2
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for WWC2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for WWC2 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WWC2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WWC2 | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for WWC2 | | OriGene 3'-UTR Clone for WWC2 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WWC2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WWC2 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for WWC2 | | OriGene Custom Protein Services for WWC2 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WWC2 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WWC2 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WWC2 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WWC2 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WWC2 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WWC2 |
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| | | Search Tocris compounds for WWC2 |
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 | | WWC2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WWC2 |
|  |  |  | | | Search ThermoFisher Antibodies for WWC2 |
| | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat WWC2 |
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