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Aliases for WWC1 Gene

Aliases for WWC1 Gene

  • WW And C2 Domain Containing 1 2 3
  • KIBRA 3 4 6
  • WW, C2 And Coiled-Coil Domain Containing 1 2 3
  • Kidney And Brain Protein 3 4
  • HBeAg-Binding Protein 3 3 4
  • MEMRYQTL 3 6
  • KIAA0869 4 6
  • Protein Phosphatase 1, Regulatory Subunit 168 3
  • WW Domain-Containing Protein 1 4
  • Regulatory Subunit 168 2
  • Protein Phosphatase 1 2
  • Protein KIBRA 3
  • Protein WWC1 3
  • PPP1R168 3
  • HBEBP36 3
  • HBEBP3 3

External Ids for WWC1 Gene

Previous GeneCards Identifiers for WWC1 Gene

  • GC05P167652
  • GC05P162818

Summaries for WWC1 Gene

Entrez Gene Summary for WWC1 Gene

  • The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

GeneCards Summary for WWC1 Gene

WWC1 (WW And C2 Domain Containing 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Hippo signaling pathway. GO annotations related to this gene include transcription coactivator activity and protein binding, bridging. An important paralog of this gene is WWC3.

UniProtKB/Swiss-Prot for WWC1 Gene

  • Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance.

Gene Wiki entry for WWC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WWC1 Gene

Genomics for WWC1 Gene

Regulatory Elements for WWC1 Gene

Genomic Location for WWC1 Gene

Start:
168,291,651 bp from pter
End:
168,472,303 bp from pter
Size:
180,653 bases
Orientation:
Plus strand

Genomic View for WWC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WWC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WWC1 Gene

Proteins for WWC1 Gene

  • Protein details for WWC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IX03-KIBRA_HUMAN
    Recommended name:
    Protein KIBRA
    Protein Accession:
    Q8IX03
    Secondary Accessions:
    • B4DK05
    • O94946
    • Q6MZX4
    • Q6Y2F8
    • Q7Z4G8
    • Q8WVM4
    • Q9BT29

    Protein attributes for WWC1 Gene

    Size:
    1113 amino acids
    Molecular mass:
    125301 Da
    Quaternary structure:
    • Homodimer. Interacts with DDN. Interacts with DYNLL1 and histone H3. The interaction with DYNLL1 is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin and the interaction with histone H3 ensures proper regulatory interaction of WWC1-DYNLL1-ESR1 complexes with target chromatin. Interacts (via WW domains) with DDR1 (via PPxY motif) in a collagen-regulated manner. Interacts with PRKCZ (via the protein kinase domain). Forms a tripartite complex with DDR1 and PRKCZ, but predominantly in the absence of collagen. Interacts (via the ADDV motif) with INADL (via PDZ domain 8). Interacts (via WW domains) with SYNPO (via PPxY motifs). Interacts with NF2 and SNX4.

    Three dimensional structures from OCA and Proteopedia for WWC1 Gene

    Alternative splice isoforms for WWC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WWC1 Gene

Proteomics data for WWC1 Gene at MOPED

Post-translational modifications for WWC1 Gene

  • Phosphorylation at Ser-542 and Ser-931 by CDK1 in response to spindle damage stress regulates mitotic exit, these two sites are dephosphorylated by CDC14B.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WWC1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for WWC1 (KIBRA)

No data available for DME Specific Peptides for WWC1 Gene

Domains for WWC1 Gene

Gene Families for WWC1 Gene

HGNC:
  • WWC :WW, C2 and coiled-coil domain containing

Protein Domains for WWC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for WWC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IX03

UniProtKB/Swiss-Prot:

KIBRA_HUMAN :
  • Q8IX03
Domain:
  • The C2-domain mediates homodimerization. It is a calcium-sensitive lipid-binding domain with preference for PI(3)P.
  • Contains 1 C2 domain.
  • Contains 2 WW domains.
Family:
  • Belongs to the WWC family. KIBRA subfamily.
genes like me logo Genes that share domains with WWC1: view

Function for WWC1 Gene

Molecular function for WWC1 Gene

UniProtKB/Swiss-Prot Function: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance.
UniProtKB/Swiss-Prot Induction: Strongly up-regulated by progestin treatment.

Gene Ontology (GO) - Molecular Function for WWC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 16684779
GO:0005515 protein binding IPI 16684779
GO:0019900 kinase binding IPI 24682284
GO:0030674 protein binding, bridging IEA --
GO:0032947 protein complex scaffold IDA 24682284
genes like me logo Genes that share ontologies with WWC1: view

Phenotypes for WWC1 Gene

MGI mutant phenotypes for WWC1:
inferred from 1 alleles
GenomeRNAi human phenotypes for WWC1:
genes like me logo Genes that share phenotypes with WWC1: view

Animal Model Products

CRISPR Products

miRNA for WWC1 Gene

miRTarBase miRNAs that target WWC1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WWC1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for WWC1 Gene

Localization for WWC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WWC1 Gene

Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Cell projection, ruffle membrane. Note=Colocalizes with PRKCZ in the perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WWC1 Gene COMPARTMENTS Subcellular localization image for WWC1 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 4
golgi apparatus 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for WWC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16684779
GO:0005737 cytoplasm IDA 16684779
GO:0005829 cytosol TAS --
GO:0032587 ruffle membrane IDA 18190796
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with WWC1: view

Pathways for WWC1 Gene

genes like me logo Genes that share pathways with WWC1: view

Pathways by source for WWC1 Gene

1 Cell Signaling Technology pathway for WWC1 Gene
2 Reactome pathways for WWC1 Gene
1 KEGG pathway for WWC1 Gene

Gene Ontology (GO) - Biological Process for WWC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 24682284
GO:0006351 transcription, DNA-templated IEA --
GO:0016477 cell migration IDA 18596123
GO:0030010 establishment of cell polarity TAS 24682284
GO:0032386 regulation of intracellular transport TAS 24682284
genes like me logo Genes that share ontologies with WWC1: view

Transcripts for WWC1 Gene

Unigene Clusters for WWC1 Gene

WW and C2 domain containing 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WWC1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for WWC1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WWC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15 ^
SP1: - -
SP2:
SP3:
SP4: -
SP5:
SP6: - - - -
SP7:
SP8: - - - -
SP9: - - - -
SP10: - - - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

ExUns: 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for WWC1 Gene

GeneLoc Exon Structure for
WWC1
ECgene alternative splicing isoforms for
WWC1

Expression for WWC1 Gene

mRNA expression in normal human tissues for WWC1 Gene

mRNA differential expression in normal tissues according to GTEx for WWC1 Gene

This gene is overexpressed in Kidney - Cortex (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WWC1 Gene

SOURCE GeneReport for Unigene cluster for WWC1 Gene Hs.484047

mRNA Expression by UniProt/SwissProt for WWC1 Gene

Q8IX03-KIBRA_HUMAN
Tissue specificity: Expressed in mammary epithelial cells and breast cancer cell lines. Found in the luminal epithelium surrounding the ducts in the normal breast. In the brain, expressed in somatodendritic compartment of neurons in the cortex and hippocampus and in the cerebellum it is found in the Purkinje cells and some granule cells (at protein level). Detected in brain, heart, colon and kidney. In the kidney, expressed in glomerular podocytes, in some tubules and in the collecting duct.
genes like me logo Genes that share expressions with WWC1: view

In Situ Assay Products

Orthologs for WWC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for WWC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WWC1 35
  • 99.55 (n)
  • 99.73 (a)
WWC1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC520730 35
  • 90.08 (n)
  • 94.58 (a)
WWC1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WWC1 35
  • 91.19 (n)
  • 95.13 (a)
WWC1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wwc1 35
  • 87.58 (n)
  • 92.11 (a)
Wwc1 16
Wwc1 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WWC1 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Wwc1 35
  • 87.05 (n)
  • 91.96 (a)
chicken
(Gallus gallus)
Aves WWC1 35
  • 72.53 (n)
  • 77.55 (a)
WWC1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WWC1 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16961 35
wwc2 35
  • 66.49 (n)
  • 70.38 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-174n5.3 35
  • 62.43 (n)
  • 60.32 (a)
WWC1 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta kibra 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5313 36
  • 61 (a)
ManyToMany
CSA.8937 36
  • 22 (a)
ManyToMany
Species with no ortholog for WWC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WWC1 Gene

ENSEMBL:
Gene Tree for WWC1 (if available)
TreeFam:
Gene Tree for WWC1 (if available)

Paralogs for WWC1 Gene

Paralogs for WWC1 Gene

Selected SIMAP similar genes for WWC1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with WWC1: view

Variants for WWC1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for WWC1 Gene

Q8IX03-KIBRA_HUMAN
Genetic variations in WWC1 define the memory quantitative trait locus (MEMRYQTL) [MIM:615602]

Sequence variations from dbSNP and Humsavar for WWC1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs14471 -- 168,469,651(-) GCGTG(G/T)CCTNT utr-variant-3-prime
rs32214 -- 168,465,718(+) atgcc(C/T)ggcta intron-variant
rs165950 -- 168,471,165(-) AAGGA(A/G)TATGC utr-variant-3-prime
rs244891 -- 168,472,480(-) GTGTG(C/G)TGTGG downstream-variant-500B
rs244892 -- 168,471,505(+) ACACT(C/G)CTCTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for WWC1 Gene

Variant ID Type Subtype PubMed ID
nsv5118 CNV Insertion 18451855
nsv5119 CNV Loss 18451855
esv271087 CNV Insertion 20981092
nsv823340 CNV Loss 20364138
nsv5120 CNV Insertion 18451855

Relevant External Links for WWC1 Gene

HapMap Linkage Disequilibrium report
WWC1
Human Gene Mutation Database (HGMD)
WWC1

Disorders for WWC1 Gene

(1) OMIM Diseases for WWC1 Gene (610533)

Relevant External Links for WWC1

Genetic Association Database (GAD)
WWC1
Human Genome Epidemiology (HuGE) Navigator
WWC1
genes like me logo Genes that share disorders with WWC1: view

No data available for UniProtKB/Swiss-Prot for WWC1 Gene

Publications for WWC1 Gene

  1. Characterization of KIBRA, a novel WW domain-containing protein. (PMID: 12559952) Kremerskothen J. … Barnekow A. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. KIBRA is a novel substrate for protein kinase Czeta. (PMID: 15081397) Buether K. … Kremerskothen J. (Biochem. Biophys. Res. Commun. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for WWC1 Gene

Sources for WWC1 Gene

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