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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

WWC1 Gene

protein-coding GIFtS: 53
GCID: GC05P167652

WW and C2 domain containing 1

(Previous names: WW, C2 and coiled-coil domain containing 1 )

Explore 9 diseases affiliated with
WWC1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
WW And C2 Domain Containing 1¹ ²		HBEBP3²
KIBRA¹ ² ³ ⁵		HBEBP36²
KIAA0869¹ ³ ⁵		Protein KIBRA²
WW, C2 And Coiled-Coil Domain Containing 1¹ ²		Protein WWC1²
Kidney And Brain Protein² ³		WW Domain-Containing Protein 1³
HBeAg-Binding Protein 3² ³

External Ids:	HGNC: 29435¹	Entrez Gene: 23286²	Ensembl: ENSG00000113645⁷	OMIM: 610533⁵	UniProtKB: Q8IX03³

Export aliases for WWC1 gene to outside databases

Previous GC identifer: GC05P162818

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WWC1:

The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light

chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants

encoding different isoforms have been found for this gene. (provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: KIBRA_HUMAN, Q8IX03

Function: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal

role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically

induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH

(Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in

DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates

directional migration of podocytes. Acts as a substrate for PRKCZ and may be associated with memory performance

Gene Wiki entry for WWC1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_023133.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the WWC1 gene promoter:
E2F-3a E2F-5 Sox5 E2F-1 E2F E2F-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): WWC1 promoter sequence

Search SABiosciences Chromatin IP Primers for WWC1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WWC1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q34 Ensembl cytogenetic band: 5q34 HGNC cytogenetic band: 5q34

WWC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WWC1 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P167652: view genomic region (about GC identifiers)

Start:	167,718,656 bp from pter	End:	167,899,308 bp from pter
Size:	180,653 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KIBRA_HUMAN, Q8IX03 (See protein sequence)

Recommended Name: Protein KIBRA

Size: 1113 amino acids; 125301 Da

Subunit: Homodimer. Interacts with DDN. Interacts with DYNLL1 and histone H3. The interaction with DYNLL1 is mandatory

for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin and the interaction with

histone H3 ensures proper regulatory interaction of WWC1-DYNLL1-ESR1 complexes with target chromatin. Interacts (via

WW domains) with DDR1 (via PPxY motif) in a collagen-regulated manner. Interacts with PRKCZ (via the protein kinase

domain). Forms a tripartite complex with DDR1 and PRKCZ, but predominantly in the absence of collagen. Interacts (via

the ADDV motif) with INADL (via PDZ domain 8). Interacts (via WW domains) with SYNPO (via PPxY motifs). Interacts with

NF2 and SNX4

Subcellular location: Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Cell projection, ruffle membrane.

Note=Co-localizes with PRKCZ in the perinuclear region

1 PDB 3D structure from and Proteopedia for WWC1:

2Z0U (3D)

Secondary accessions: B4DK05 O94946 Q6MZX4 Q6Y2F8 Q7Z4G8 Q8WVM4 Q9BT29

Alternative splicing: 2 isoforms: Q8IX03-1 Q8IX03-2

Explore the universe of human proteins at neXtProt for WWC1: NX_Q8IX03

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IX03

WWC1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001155133.1 NP_001155134.1 NP_056053.1

ENSEMBL proteins:

ENSP00000265293 ENSP00000427772 ENSP00000377473 ENSP00000429339 ENSP00000428084

Reactome Protein details: Q8IX03
Human Recombinant Protein Products for WWC1:

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	Uscn Proteins for WWC1

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	16684779
GO:0005737	cytoplasm	IDA	16684779
GO:0005794	Golgi apparatus	IDA	--
GO:0005829	cytosol	TAS	--
GO:0032587	ruffle membrane	IDA	18190796

WWC1 for ontologies About GeneDecksing

WWC1 Antibody Products:

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

WWC1 for domains About GeneDecksing

2 InterPro domains/families:

IPR008973 C2_Ca/lipid-bd_dom_CaLB

IPR001202 WW_Rsp5_WWP

Graphical View of Domain Structure for InterPro Entry Q8IX03

ProtoNet protein and cluster: Q8IX03

UniProtKB/Swiss-Prot: KIBRA_HUMAN, Q8IX03

Domain: The C2-domain mediates homodimerization

Similarity: Belongs to the WWC family. KIBRA subfamily

Similarity: Contains 1 C2 domain

Similarity: Contains 2 WW domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: KIBRA_HUMAN, Q8IX03

Function: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal

role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically

induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH

(Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in

DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates

directional migration of podocytes. Acts as a substrate for PRKCZ and may be associated with memory performance

Induction: Strongly up-regulated by progestin treatment

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003713	transcription coactivator activity	IDA	16684779
GO:0005515	protein binding	IPI	17994011
GO:0030674	protein binding, bridging	IEA	--

WWC1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for WWC1:

Synthetic lethal with Ras

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Wwc1):

behavior/neurological

nervous system

WWC1 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for WWC1

miRNA Products:		OriGene 3'-UTR Clone (see all 3): WWC1 Browse MicroRNA Expression Plasmids
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		8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate WWC1 (see all 59):
		hsa-miR-579 hsa-miR-21* hsa-miR-300 hsa-miR-1914* hsa-miR-15a hsa-miR-513a-5p hsa-miR-25 hsa-let-7a-2*

		SwitchGear 3'UTR luciferase reporter plasmid: WWC1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WWC1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by Hippo

Signaling by Hippo

1.00

Wnt / Hedgehog / Notch

Wnt / Hedgehog / Notch

1.00

Signaling by GPCR

Signal Transduction

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for WWC1

Wnt / Hedgehog / Notch

2 Reactome Pathways for WWC1

	Signaling by Hippo
	Signal Transduction

WWC1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for WWC1

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/31 Interacting proteins for WWC1 (Q8IX03^{2, 3} ENSP00000265293⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 31)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H3A	P68431³, ENSP00000350275⁴	I2D: score=1 STRING: ENSP00000350275
HIST1H3B	P68431³	I2D: score=1
HIST1H3C	P68431³	I2D: score=1
HIST1H3D	P68431³	I2D: score=1
HIST1H3E	P68431³	I2D: score=1

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0016477	cell migration	IDA	18596123
GO:0035329	hippo signaling cascade	TAS	--
GO:0035330	regulation of hippo signaling cascade	IMP	--

WWC1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for WWC1
Search CenterWatch for drugs/clinical trials and news about WWC1 / KIBRA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for WWC1 gene (3 alternative transcripts):

NM_001161661.1 NM_001161662.1 NM_015238.2

Unigene Cluster for WWC1:

WW and C2 domain containing 1

Hs.484047 [show with all ESTs]

Unigene Representative Sequence: NM_001161661

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000265293(uc003lzv.3 uc011den.2 uc003lzu.3 uc003lzw.3)

ENST00000521089(uc010jjf.1) ENST00000523043 ENST00000519859 ENST00000393895

ENST00000519659 ENST00000517425 ENST00000524228 ENST00000517646 ENST00000522660

ENST00000518334 ENST00000524093 ENST00000524038 ENST00000522140 ENST00000521391

ENST00000518204

miRNA Products:		OriGene 3'-UTR Clone (see all 3): WWC1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WWC1
		8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate WWC1 (see all 59):
		hsa-miR-579 hsa-miR-21* hsa-miR-300 hsa-miR-1914* hsa-miR-15a hsa-miR-513a-5p hsa-miR-25 hsa-let-7a-2*

		SwitchGear 3'UTR luciferase reporter plasmid: WWC1 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WWC1

Additional cDNA sequence:

AB020676.1 AF506799.1 AF530058.1 AK001727.1 AK027022.1 AK296323.1 AY189820.1 BC004394.1

BC017746.1 BC038463.1 BC042553.1 BX640827.1

15 DOTS entries:

DT.99970293 DT.412304 DT.75100546 DT.100730916 DT.100785439 DT.95299629 DT.208542 DT.75100154

DT.107899 DT.92426669 DT.120817112 DT.92426665 DT.95138467 DT.95264615 DT.427876

24/146 AceView cDNA sequences (see all 146):

BM931561 AK001727 AB020676 BC004394 AA659728 BF033021 BU632534 AK027022

BE551084 AI421231 BC042553 BM977017 R35143 CB156571 AK126376 BG674332

AI741792 AF530058 AW027395 CB306998 BU681129 BM772893 CA313404 BM674883

GeneLoc Exon Structure

5/17 Alternative Splicing Database (ASD) splice patterns (SP) for WWC1 (see all 17) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	·	7d	^	8a	·	8b	·	8c	^	9a	·	9b	·	9c	^	10	^	11	^	12a	·	12b	·	12c	^	13	^	14a	·	14b	^	15	^
SP1:																																	-						-
SP2:
SP3:
SP4:			-
SP5:

ExUns:	16	^	17a	·	17b	·	17c	^	18	^	19	^	20	^	21a	·	21b	^	22	^	23a	·	23b	^	24	^	25a	·	25b	^	26a	·	26b	^	27a	·	27b
SP1:
SP2:																											-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for WWC1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

WWC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See WWC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WWC1

SOURCE GeneReport for Unigene cluster: Hs.484047

UniProtKB/Swiss-Prot: KIBRA_HUMAN, Q8IX03

Tissue specificity: Expressed in mammary epithelial cells and breast cancer cell lines. Found in the luminal epithelium

surrounding the ducts in the normal breast. In the brain, expressed in somatodendritic compartment of neurons in the

cortex and hippocampus and in the cerebellum it is found in the Purkinje cells and some granule cells (at protein

level). Detected in brain, heart, colon and kidney. In the kidney, expressed in glomerular podocytes, in some tubules

and in the collecting duct

SABiosciences Custom PCR Arrays for WWC1

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WWC1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for WWC1 gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Wwc1^{1 , 5}	WW, C2 and coiled-coil domain containing 1^{1, 5}	87.99(n)¹ 92.74(a)¹		11 (21.96 cM)⁵ 211652¹ NM_170779.1¹ NP_740749.1¹ 35838400⁵
chicken (Gallus gallus)	Aves	WWC1¹	WW and C2 domain containing 1	72.75(n) 78.12(a)		416167 XM_414499.3 XP_414499.3
lizard (Anolis carolinensis)	Reptilia	WWC1⁶	--	72(a)	1 ↔ 1	1(112476817-112530217)
African clawed frog (Xenopus laevis)	Amphibia	BC042930.1²	--	76.17(n)		BC042930.1
zebrafish (Danio rerio)	Actinopterygii	LOC560785¹	protein KIBRA-like	61.95(n) 59.31(a)		560785 XM_684183.4 XP_689275.4
fruit fly (Drosophila melanogaster)	Insecta	kibra¹	kibra ortholog	48.15(n) 38.42(a)		41783 NM_001038966.1 NP_001034055.1

ENSEMBL Gene Tree for WWC1 (if available)
TreeFam Gene Tree for WWC1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for WWC1 gene

WWC3² WWC2²

2 SIMAP similar genes for WWC1 using alignment to 5 protein entries: KIBRA_HUMAN (see all proteins):

WWC2 WWC3

WWC1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs72838315^1,2	C	--	162816320(+)	`ATGGGG/TAAGTT`	3	--	us2k¹		2		NA	122
rs34669686^1,2	C,F	--	162968849(+)	`ACATC-/AAAAAA`	1	--	int¹		3		NA CSA	6
rs145386364^1,2		--	167717108(+)	`TGTCCC/TTGGAC`	3	--	us2k¹		0	--	--	--	--
rs141471478^1,2		--	167717133(+)	`TTTATA/GGAATG`	3	--	us2k¹		0	--	--	--	--
rs11948353^1,2	C,F,H	--	167717162(+)	`AGCCCC/TGAGGC`	3	--	us2k¹		5		NS EA WA	528
rs12108717^1,2	C,F,A,H	--	167717163(+)	`GCCCCG/AAGGCC`	3	--	us2k¹		8		NS EA NA CSA WA	654
rs76294873^1,2		--	167717188(+)	`GAATTA/TACTAT`	3	--	us2k¹		1		NA	120
rs17051827^1,2	C,F,H	--	167717409(+)	`GGGCAA/GAAAAG`	3	--	us2k¹		12		NA NS EA WA	1630
rs78222360^1,2	C	--	167717462(+)	`GAAGTC/GAACAG`	3	--	us2k¹		0	--	--	--	--
rs76959125^1,2	C	--	167717464(+)	`AGTGAA/CCAGCC`	3	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for WWC1 (167718656 - 167899308 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for WWC1: --
Human Gene Mutation Database (HGMD): WWC1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

WWC1 for disorders           About GeneDecksing

OMIM gene information: 610533    OMIM disorders: --

9 diseases for WWC1:    About MalaCards

memory, enhanced, association with acute lymphocytic leukemia lymphocytic leukemia conjunctivitis

alzheimer's disease leukemia breast cancer schizophrenia

neuronitis

Human Genome Epidemiology (HuGE) Navigator: WWC1 (19 documents)

Export disorders for WWC1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for WWC1 gene, integrated from 9 sources (see all 57):
(articles sorted by number of sources associating them with WWC1)

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world of online information

Characterization of KIBRA, a novel WW domain-containing protein. (PubMed id 12559952)^{1, 2, 3, 9} Kremerskothen J.... Barnekow A. (2003)
Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)^{1, 2, 3} Nagase T....Ohara O. (1998)
KIBRA modulates directional migration of podocytes. (PubMed id 18596123)^{1, 2} Duning K.... Pavenstaedt H. (2008)
KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling. (PubMed id 18190796)^{1, 2} Hilton H.N.... Ormandy C.J. (2008)
Temporal-spatial expression and novel biochemical properties of the memory-related protein KIBRA. (PubMed id 18672031)^{1, 2} Johannsen S....Boeckers T.M. (2008)
SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment. (PubMed id 17994011)^{1, 2} Traer C.J....Cullen P.J. (2007)
Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells. (PubMed id 16684779)^{1, 2} Rayala S.K.... Kumar R. (2006)
KIBRA is a novel substrate for protein kinase Czeta. (PubMed id 15081397)^{1, 2} Buther K....Kremerskothen J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23286	HGNC: 29435	AceView: KIBRA	Ensembl:ENSG00000113645	euGenes: HUgn23286
ECgene: WWC1	H-InvDB: WWC1

(According to HUGE)
About This Section

HUGE: KIAA0869

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for WWC1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for WWC1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for WWC1 gene:
Search GeneIP for patents involving WWC1

GeneCards and IP:
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WW and C2 domain containing 1

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WW and C2 domain containing 1

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