Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WTIP Gene

Aliases for WTIP Gene

  • Wilms Tumor 1 Interacting Protein 2 3
  • WT1-Interacting Protein 2 4

External Ids for WTIP Gene

Summaries for WTIP Gene

GeneCards Summary for WTIP Gene

WTIP (Wilms Tumor 1 Interacting Protein) is a Protein Coding gene. Diseases associated with WTIP include wilms tumor. Among its related pathways are Hippo signaling pathway. An important paralog of this gene is AJUBA.

UniProtKB/Swiss-Prot for WTIP Gene

  • Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WTIP Gene

Genomics for WTIP Gene

Genomic Location for WTIP Gene

Start:
34,481,638 bp from pter
End:
34,512,304 bp from pter
Size:
30,667 bases
Orientation:
Plus strand

Genomic View for WTIP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WTIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WTIP Gene

Regulatory Elements for WTIP Gene

Proteins for WTIP Gene

  • Protein details for WTIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NIX2-WTIP_HUMAN
    Recommended name:
    Wilms tumor protein 1-interacting protein
    Protein Accession:
    A6NIX2
    Secondary Accessions:

    Protein attributes for WTIP Gene

    Size:
    430 amino acids
    Molecular mass:
    45124 Da
    Quaternary structure:
    • Forms homodimers (By similarity). Interacts with CD2AP and WT1. Interacts (via LIM domains) with SNAI1 (via SNAG domain), SNAI2/SLUG (via SNAG domain) and SCRT1 (via SNAG domain) (By similarity). Interacts with EIF4E, AGO1, AGO2, DCP2, DDX6, LATS1, LATS2, SAV1, EGLN2/PHD1 and EGLN3/PHD3. Interacts (via LIM domains) with isoform 1 and isoform 3 of VHL. Interacts with ROR2 (By similarity). Following treatment with bacterial lipopolysaccharide (LPS), forms a complex with MAPK8IP3 and dynein intermediate chain (By similarity).

neXtProt entry for WTIP Gene

Proteomics data for WTIP Gene at MOPED

Post-translational modifications for WTIP Gene

No Post-translational modifications

Other Protein References for WTIP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WTIP Gene

Domains for WTIP Gene

Protein Domains for WTIP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for WTIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NIX2

UniProtKB/Swiss-Prot:

WTIP_HUMAN
Domain:
  • Contains 3 LIM zinc-binding domains.:
    • A6NIX2
Family:
  • Belongs to the zyxin/ajuba family.:
    • A6NIX2
genes like me logo Genes that share domains with WTIP: view

No data available for Gene Families for WTIP Gene

Function for WTIP Gene

Molecular function for WTIP Gene

UniProtKB/Swiss-Prot Function: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype.

Gene Ontology (GO) - Molecular Function for WTIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IEA --
GO:0005515 protein binding IPI 20303269
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with WTIP: view

Phenotypes for WTIP Gene

GenomeRNAi human phenotypes for WTIP:
genes like me logo Genes that share phenotypes with WTIP: view

miRNA for WTIP Gene

miRTarBase miRNAs that target WTIP

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for WTIP Gene

Localization for WTIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for WTIP Gene

Cell junction, adherens junction. Nucleus. Cytoplasm, P-body. Note=Following podocyte injury, caused by treatment with LPS, puromycin aminonucleoside, ultraviolet or hydrogen peroxide, translocates from sites of cell-cell contacts into the cytosol and nucleus. The shift from cell contacts to intracellular plaques starts as early as 1 hour after LPS stimulation and intranuclear localization begins 3 hours after LPS treatment. Maximal nuclear localization is achieved 6 hours after LPS treatment. Nuclear translocation requires dynein motor activity and intact microtubule network (By similarity). Returns to cell-cell contacts 24 hours after LPS stimulation. In the presence of ROR2, localizes to the plasma membrane (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WTIP Gene COMPARTMENTS Subcellular localization image for WTIP gene
Compartment Confidence
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for WTIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body IDA 20616046
GO:0005634 nucleus IEA --
GO:0005912 adherens junction IEA --
GO:0030054 cell junction --
genes like me logo Genes that share ontologies with WTIP: view

Pathways for WTIP Gene

SuperPathways for WTIP Gene

Superpath Contained pathways
1 Hippo signaling pathway
genes like me logo Genes that share pathways with WTIP: view

Pathways by source for WTIP Gene

1 KEGG pathway for WTIP Gene

Interacting Proteins for WTIP Gene

Gene Ontology (GO) - Biological Process for WTIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IDA 22286099
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007010 cytoskeleton organization IMP 21834987
GO:0022604 regulation of cell morphogenesis IMP 21834987
genes like me logo Genes that share ontologies with WTIP: view

Transcripts for WTIP Gene

mRNA/cDNA for WTIP Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WTIP Gene

Wilms tumor 1 interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WTIP Gene

No ASD Table

Relevant External Links for WTIP Gene

GeneLoc Exon Structure for
WTIP
ECgene alternative splicing isoforms for
WTIP

Expression for WTIP Gene

mRNA expression in normal human tissues for WTIP Gene

mRNA differential expression in normal tissues according to GTEx for WTIP Gene

This gene is overexpressed in Artery - Tibial (6.3), Artery - Coronary (5.0), and Artery - Aorta (4.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for WTIP Gene

SOURCE GeneReport for Unigene cluster for WTIP Gene Hs.585010

genes like me logo Genes that share expressions with WTIP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for WTIP Gene

Orthologs for WTIP Gene

This gene was present in the common ancestor of animals.

Orthologs for WTIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WTIP 35
  • 99.37 (n)
  • 100 (a)
WTIP 36
  • 61 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WTIP 35
  • 90.23 (n)
  • 93.95 (a)
WTIP 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WTIP 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wtip 35
  • 85.15 (n)
  • 90.2 (a)
Wtip 16
Wtip 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WTIP 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WTIP 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wtip 35
  • 88.78 (n)
  • 96.15 (a)
chicken
(Gallus gallus)
Aves WTIP 36
  • 37 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii wtip 36
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta jub 36
  • 25 (a)
OneToMany
Species with no ortholog for WTIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WTIP Gene

ENSEMBL:
Gene Tree for WTIP (if available)
TreeFam:
Gene Tree for WTIP (if available)

Paralogs for WTIP Gene

Paralogs for WTIP Gene

Selected SIMAP similar genes for WTIP Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with WTIP: view

Variants for WTIP Gene

Sequence variations from dbSNP and Humsavar for WTIP Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1122110 -- 34,497,787(+) GACAA(C/G)GAGCA intron-variant
rs1465433 -- 34,482,508(-) AAGGG(A/G)GCCGG synonymous-codon, reference, upstream-variant-2KB
rs2059147 -- 34,500,685(-) CTGCC(C/T)GGGAG utr-variant-3-prime
rs2277979 -- 34,494,049(+) GGGAG(C/G)TCTGG intron-variant
rs2277980 -- 34,493,797(-) CCACC(A/G)GGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WTIP Gene

Variant ID Type Subtype PubMed ID
nsv517392 CNV Gain+Loss 19592680
esv22345 CNV Loss 19812545

Relevant External Links for WTIP Gene

HapMap Linkage Disequilibrium report
WTIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WTIP Gene

Disorders for WTIP Gene

(1) MalaCards Diseases for WTIP Gene

Search for WTIP Gene in MalaCards »

Relevant External Links for WTIP

Genetic Association Database (GAD)
WTIP
genes like me logo Genes that share disorders with WTIP: view

No data available for UniProtKB/Swiss-Prot for WTIP Gene

Publications for WTIP Gene

  1. A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus. (PMID: 14736876) Srichai M.B. … Sedor J.R. (J. Biol. Chem. 2004) 2 3 23
  2. Podocyte injury induces nuclear translocation of WTIP via microtubule-dependent transport. (PMID: 20086015) Kim J.H. … Sedor J.R. (J. Biol. Chem. 2010) 3 4
  3. Ajuba LIM proteins are negative regulators of the Hippo signaling pathway. (PMID: 20303269) Das Thakur M. … Longmore G.D. (Curr. Biol. 2010) 3 4
  4. LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. (PMID: 20616046) James V. … Sharp T.V. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4
  5. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PMID: 21834987) Bai S.W. … Ridley A.J. (BMC Biol. 2011) 3 4

Products for WTIP Gene

Sources for WTIP Gene

Back to Top

Content