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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WTIP Gene

protein-coding   GIFtS: 48
GCID: GC19P034971

Wilms Tumor 1 Interacting Protein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Wilms Tumor 1 Interacting Protein1 2
WT1-Interacting Protein1 2 3
Wilms Tumor Protein 1-Interacting Protein2

External Ids:    HGNC: 209641   Entrez Gene: 1263742   Ensembl: ENSG000001422797   OMIM: 6147905   UniProtKB: A6NIX23   

Export aliases for WTIP gene to outside databases

Previous GC identifers: GC19P039665 GC19P039663 GC19P031481


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for WTIP Gene: 
WTIP (Wilms tumor 1 interacting protein) is a protein-coding gene. Diseases associated with WTIP include wilms tumor, and kidney disease. GO annotations related to this gene include transcription corepressor activity and zinc ion binding. An important paralog of this gene is LPP.

UniProtKB/Swiss-Prot: WTIP_HUMAN, A6NIX2
Function: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is
involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of
gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates
microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes
phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of
E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases
and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin
dynamics and/or foot process cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into
the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby
translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WTIP gene promoter:
         Sox5   HTF   FOXD3   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   c-Rel   POU2F1   POU2F1a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for WTIP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WTIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.11   Ensembl cytogenetic band:  19q13.11   HGNC cytogenetic band: 19q13.11

WTIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WTIP gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P034971:  view genomic region     (about GC identifiers)

Start:
34,971,874 bp from pter      End:
34,997,258 bp from pter
Size:
25,385 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WTIP_HUMAN, A6NIX2 (See protein sequence)
Recommended Name: Wilms tumor protein 1-interacting protein  
Size: 430 amino acids; 45124 Da
Subunit: Forms homodimers (By similarity). Interacts with CD2AP and WT1. Interacts (via LIM domains) with SNAI1
(via SNAG domain), SNAI2/SLUG (via SNAG domain) and SCRT1 (via SNAG domain) (By similarity). Interacts with
EIF4E, AGO1, AGO2, DCP2, DDX6, LATS1, LATS2, SAV1, EGLN2/PHD1 and EGLN3/PHD3. Interacts (via LIM domains) with
isoform 1 and isoform 3 of VHL. Interacts with ROR2 (By similarity). Following treatment with bacterial
lipopolysaccharide (LPS), forms a complex with MAPK8IP3 and dynein intermediate chain (By similarity)
Subcellular location: Cell junction, adherens junction. Nucleus (By similarity). Cytoplasm, P-body. Note=Following
podocyte injury, caused by treatment with LPS, puromycin aminonucleoside, ultraviolet or hydrogen peroxide,
translocates from sites of cell-cell contacts into the cytosol and nucleus. The shift from cell contacts to
intracellular plaques starts as early as 1 hour after LPS stimulation and intranuclear localization begins 3
hours after LPS treatment. Maximal nuclear localization is achieved 6 hours after LPS treatment. Nuclear
translocation requires dynein motor activity and intact microtubule network (By similarity). Returns to cell-cell
contacts 24 hours after LPS stimulation. In the presence of ROR2, localizes to the plasma membrane (By
similarity)

Explore the universe of human proteins at neXtProt for WTIP: NX_A6NIX2

Explore proteomics data for WTIP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A6NIX2

  • WTIP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WTIP Protein Expression
    REFSEQ proteins: NP_001073905.1  
    ENSEMBL proteins: 
     ENSP00000466953   ENSP00000465683   ENSP00000270288  

    Human Recombinant Protein Products for WTIP: 
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    OriGene MassSpec for WTIP 
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    Novus Biologicals WTIP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WTIP 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IDA--
    GO:0005634nucleus IEA--
    GO:0005912adherens junction IEA--

    WTIP for ontologies           About GeneDecksing



    WTIP Antibody Products: 
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    Cloud-Clone Corp. Antibodies for WTIP 
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    LSBio Antibodies in human, mouse, rat for WTIP 

    Assay Products for WTIP: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for WTIP 
    Cloud-Clone Corp. CLIAs for WTIP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry A6NIX2

    ProtoNet protein and cluster: A6NIX2

    UniProtKB/Swiss-Prot: WTIP_HUMAN, A6NIX2
    Similarity: Belongs to the zyxin/ajuba family
    Similarity: Contains 3 LIM zinc-binding domains


    WTIP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WTIP_HUMAN, A6NIX2
    Function: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is
    involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of
    gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates
    microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes
    phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of
    E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases
    and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin
    dynamics and/or foot process cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into
    the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby
    translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity ----
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
         
    WTIP for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for WTIP:
     Increased 8N DNA content  Increased cell size 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for WTIP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for WTIP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WTIP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WTIP 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WTIP
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate WTIP (see all 11):
    hsa-miR-548am hsa-miR-224 hsa-miR-3133 hsa-miR-3647-3p hsa-miR-646 hsa-miR-186 hsa-miR-548x hsa-miR-3121-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for WTIP
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    GenScript: all cDNA clones in your preferred vector: WTIP (NM_001080436)
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                         Customized lentivirus expression plasmids for stable overexpression of WTIP 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WTIP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for WTIP About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Hippo signaling pathway
    Hippo signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for WTIP):
        Hippo signaling pathway


    WTIP for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WTIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for WTIP (ENSP000002702884) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD2APENSP000003522644STRING: ENSP00000352264
    WT1ENSP000003313274STRING: ENSP00000331327
    RARAENSP000002540664STRING: ENSP00000254066
    EGLN2ENSP000003070804STRING: ENSP00000307080
    EGLN3ENSP000002504574STRING: ENSP00000250457
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IDA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0007010cytoskeleton organization IMP--
    GO:0022604regulation of cell morphogenesis IMP--

    WTIP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WTIP

    Search CenterWatch for drugs/clinical trials and news about WTIP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WTIP gene: 
    NM_001080436.1  

    Unigene Cluster for WTIP:

    Wilms tumor 1 interacting protein
    Hs.585010  [show with all ESTs]
    Unigene Representative Sequence: NM_001080436
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000590071 ENST00000585928 ENST00000270288(uc002nvm.3)
    miRNA
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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate WTIP (see all 11):
    hsa-miR-548am hsa-miR-224 hsa-miR-3133 hsa-miR-3647-3p hsa-miR-646 hsa-miR-186 hsa-miR-548x hsa-miR-3121-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for WTIP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WTIP
    Clone
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    OriGene clones in human, mouse for WTIP (see all 6)
    OriGene ORF clones in mouse, rat for WTIP
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    GenScript: all cDNA clones in your preferred vector: WTIP (NM_001080436)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WTIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WTIP
    Sirion Biotech Customized lentivirus for stable overexpression of WTIP 
                         Customized lentivirus expression plasmids for stable overexpression of WTIP 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for WTIP
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WTIP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WTIP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WTIP

    Additional mRNA sequence: 

    AK130059.1 BC030216.1 

    4 DOTS entries:

    DT.40290983  DT.212492  DT.99948993  DT.91876490 

    1 AceView cDNA sequence:

    BM711847 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WTIP expression in normal human tissues (normalized intensities)      WTIP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGTTCCTG
    WTIP Expression
    About this image


    WTIP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Ovary (Reproductive System)

    See WTIP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WTIP

    SOURCE GeneReport for Unigene cluster: Hs.585010
        SABiosciences Custom PCR Arrays for WTIP
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WTIP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for WTIP gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wtip1 , 5 WT1-interacting protein1, 5 86.31(n)1
    91.69(a)1
      7 (19.40 cM)5
    1015431  NM_207212.21  NP_997095.11 
     341095435 
    chicken
    (Gallus gallus)
    Aves WTIP6
    Uncharacterized protein
    36(a)
    1 ↔ 1
    11(10526664-10597453)
    zebrafish
    (Danio rerio)
    Actinopterygii wtip6
    Wilms tumor 1 interacting protein
    37(a)
    1 ↔ 1
    13(52035437-52091780)
    fruit fly
    (Drosophila melanogaster)
    Insecta jub6
    Ajuba LIM protein
    24(a)
    1 → many
    X(13720363-13724347)


    ENSEMBL Gene Tree for WTIP (if available)
    TreeFam Gene Tree for WTIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WTIP gene
    LPP2  TRIP62  FBLIM12  AJUBA2  ZYX2  LIMD12  
    9 SIMAP similar genes for WTIP using alignment to 2 protein entries:     WTIP_HUMAN (see all proteins):
    AJUBA    LIMD1    LHX8    LHX6    LMO3    LIMS1
    ABLIM3    LHX4    LMO1

    WTIP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/460 SNPs in WTIP are shown (see all 460)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1928279181,2
    --34970909(+) TTATAC/TGACAC 1 -- us2k10--------
    rs1837431161,2
    --34970914(+) CGACAC/TGGTTG 1 -- us2k10--------
    rs1886713881,2
    C--34970915(+) GACACG/TGTTGT 1 -- us2k10--------
    rs1932826251,2
    --34970937(+) TGTCTC/GCATTT 1 -- us2k10--------
    rs1842640721,2
    --34971017(+) GGATGC/TTGACA 1 -- us2k10--------
    rs1168311851,2
    C--34971166(+) TGAACG/TGGCTT 1 -- us2k10--------
    rs1884450801,2
    --34971262(+) CGCACA/GGAGTC 1 -- us2k10--------
    rs72575881,2
    C,F--34971763(+) ACAGAC/TAACGG 1 -- us2k1 tfbs311Minor allele frequency- T:0.37NA WA CSA EA 374
    rs43448661,2
    C,F,A,H--34971846(+) GTCACT/CTCTCG 1 -- us2k122Minor allele frequency- C:0.41NS EA NA WA CSA 2348
    rs72487051,2
    C,F--34971998(+) GGCTCA/GCCGCC 1 -- us2k16Minor allele frequency- G:0.18NA WA CSA 11

    HapMap Linkage Disequilibrium report for WTIP (34971874 - 34997258 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for WTIP:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv22345CNV Loss19812545
    nsv517392CNV Gain+Loss19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing WTIP
    DNA2.0 Custom Variant and Variant Library Synthesis for WTIP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614790    OMIM disorders: --

    3 diseases for WTIP:    About MalaCards
    wilms tumor    kidney disease    hypoxia


    WTIP for disorders           About GeneDecksing

    Genetic Association Database (GAD): WTIP

    Export disorders for WTIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WTIP gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with WTIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus. (PubMed id 14736876)1, 3, 9 Srichai M.B....Sedor J.R. (2004)
    2. The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. (PubMed id 22286099)1, 2 Foxler D.E.... Sharp T.V. (2012)
    3. Podocyte injury induces nuclear translocation of WTIP via microtubule-dependent transport. (PubMed id 20086015)1, 2 Kim J.H....Sedor J.R. (2010)
    4. WT1-interacting protein (Wtip) regulates podocyte phe notype by cell-cell and cell-matrix contact reorganization. (PubMed id 21900451)1 Kim J.H....Sedor J.R. (2012)
    5. Out on a LIM: chronic kidney disease, podocyte phenot ype and the Wilm's tumor interacting protein (WTIP). (PubMed id 21686224)1 Sedor J.R....Konieczkowski M. (2011)
    6. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PubMed id 21834987)2 Bai S.W.... Ridley A.J. (2011)
    7. Ajuba LIM proteins are negative regulators of the Hip po signaling pathway. (PubMed id 20303269)2 Das Thakur M....Longmore G.D. (2010)
    8. LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. (PubMed id 20616046)2 James V.... Sharp T.V. (2010)
    9. LIM protein Ajuba functions as a nuclear receptor cor epressor and negatively regulates retinoic acid signaling. (PubMed id 20133701)1 Hou Z....Rauscher F.J. (2010)
    10. The LIM domain protein Wtip interacts with the recept or tyrosine kinase Ror2 and inhibits canonical Wnt signalling. (PubMed id 19785987)1 van Wijk N.V....Stricker S. (2009)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 126374 HGNC: 20964 AceView: WTIP.1 Ensembl:ENSG00000142279 euGenes: HUgn126374
    ECgene: WTIP Kegg: 126374 H-InvDB: WTIP

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    NameDescription
    PharmGKB entry for WTIP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WTIP Genetics and Cytogenetics in Oncology and Haematology

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