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Aliases for WTIP Gene

Aliases for WTIP Gene

  • WT1 Interacting Protein 2 3 5
  • WT1-Interacting Protein 2 4
  • Wilms Tumor 1 Interacting Protein 2

External Ids for WTIP Gene

Previous GeneCards Identifiers for WTIP Gene

  • GC19P039665
  • GC19P039663
  • GC19P034971
  • GC19P031481

Summaries for WTIP Gene

GeneCards Summary for WTIP Gene

WTIP (WT1 Interacting Protein) is a Protein Coding gene. Diseases associated with WTIP include Wilms Tumor 1 and Chromosome 19Q13.11 Deletion Syndrome. Among its related pathways are Hippo signaling pathway - multiple species and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity. An important paralog of this gene is LIMD1.

UniProtKB/Swiss-Prot for WTIP Gene

  • Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype. Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity).

Additional gene information for WTIP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WTIP Gene

Genomics for WTIP Gene

GeneHancer (GH) Regulatory Elements for WTIP Gene

Promoters and enhancers for WTIP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I034480 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 559.3 +0.2 214 3.1 ARID4B SIN3A DMAP1 ZNF2 ETS1 ZNF121 GLIS2 ZNF143 KLF7 KLF13 WTIP ZNF599 LSM14A KIAA0355 RPS26P55
GH19I034170 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.5 -308.5 -308492 5.2 FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF143 NFYC ZC3H11A SSRP1 ZNF610 LSM14A GC19M034171 ZNF599 ZNF792 KIAA0355 ZNF302 ZNF181 ENSG00000271032 WTIP ZNF30
GH19I033819 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 31.1 -661.0 -660995 2.8 ZFP64 ARID4B SIN3A FEZF1 ZNF213 ZNF302 ZNF416 KLF13 SP3 ZC3H11A GPATCH1 CEP89 ZNF599 LSM14A KIAA0355 ZNF181 ENSG00000267219 WTIP FAAP24 ENSG00000271049
GH19I035461 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 22.4 +981.3 981313 1.9 HDGF PKNOX1 SMAD1 ZNF493 ZFP64 IRF4 ZNF121 ZNF213 ATF7 KLF7 TMEM147-AS1 HAUS5 ZNF599 KMT2B PROSER3 RBM42 ZFP82 ZNF146 ZNF792 ZNF302
GH19I035322 Enhancer 1.2 ENCODE dbSUPER 31.1 +842.2 842184 2.6 HDGF PKNOX1 SMAD1 ZNF493 ZFP64 ZNF121 ZNF213 ZNF302 ATF7 KLF7 TMEM147-AS1 HAUS5 ZNF599 KMT2B PROSER3 ZNF792 RBM42 ZNF146 ZNF181 U2AF1L4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WTIP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WTIP gene promoter:

Genomic Locations for WTIP Gene

Genomic Locations for WTIP Gene
chr19:34,481,638-34,512,304
(GRCh38/hg38)
Size:
30,667 bases
Orientation:
Plus strand
chr19:34,971,874-34,997,258
(GRCh37/hg19)

Genomic View for WTIP Gene

Genes around WTIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WTIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WTIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WTIP Gene

Proteins for WTIP Gene

  • Protein details for WTIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NIX2-WTIP_HUMAN
    Recommended name:
    Wilms tumor protein 1-interacting protein
    Protein Accession:
    A6NIX2

    Protein attributes for WTIP Gene

    Size:
    430 amino acids
    Molecular mass:
    45124 Da
    Quaternary structure:
    • Forms homodimers (By similarity). Interacts with CD2AP and WT1. Interacts (via LIM domains) with SNAI1 (via SNAG domain), SNAI2/SLUG (via SNAG domain) and SCRT1 (via SNAG domain) (By similarity). Interacts with EIF4E, AGO1, AGO2, DCP2, DDX6, LATS1, LATS2, SAV1, EGLN2/PHD1 and EGLN3/PHD3. Interacts (via LIM domains) with isoform 1 and isoform 3 of VHL. Interacts with ROR2 (By similarity). Following treatment with bacterial lipopolysaccharide (LPS), forms a complex with MAPK8IP3 and dynein intermediate chain (By similarity). Interacts with PRICKLE3 (By similarity).

neXtProt entry for WTIP Gene

Post-translational modifications for WTIP Gene

No Post-translational modifications

Other Protein References for WTIP Gene

No data available for DME Specific Peptides for WTIP Gene

Domains & Families for WTIP Gene

Gene Families for WTIP Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for WTIP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for WTIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NIX2

UniProtKB/Swiss-Prot:

WTIP_HUMAN :
  • Belongs to the zyxin/ajuba family.
Family:
  • Belongs to the zyxin/ajuba family.
genes like me logo Genes that share domains with WTIP: view

Function for WTIP Gene

Molecular function for WTIP Gene

UniProtKB/Swiss-Prot Function:
Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype. Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity).

Gene Ontology (GO) - Molecular Function for WTIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IBA,IEA --
GO:0005515 protein binding IPI 20303269
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with WTIP: view
genes like me logo Genes that share phenotypes with WTIP: view

Animal Models for WTIP Gene

MGI Knock Outs for WTIP:
  • Wtip tm1b(KOMP)Wtsi

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WTIP Gene

Localization for WTIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for WTIP Gene

Cell junction, adherens junction. Nucleus. Cytoplasm, P-body. Note=Following podocyte injury, caused by treatment with LPS, puromycin aminonucleoside, ultraviolet or hydrogen peroxide, translocates from sites of cell-cell contacts into the cytosol and nucleus. The shift from cell contacts to intracellular plaques starts as early as 1 hour after LPS stimulation and intranuclear localization begins 3 hours after LPS treatment. Maximal nuclear localization is achieved 6 hours after LPS treatment. Nuclear translocation requires dynein motor activity and intact microtubule network (By similarity). Returns to cell-cell contacts 24 hours after LPS stimulation. In the presence of ROR2, localizes to the plasma membrane (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WTIP gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for WTIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IDA 20616046
GO:0005634 nucleus IBA --
GO:0005667 transcription factor complex IBA --
GO:0005737 cytoplasm IEA --
GO:0005911 cell-cell junction IBA --
genes like me logo Genes that share ontologies with WTIP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for WTIP Gene

Pathways & Interactions for WTIP Gene

genes like me logo Genes that share pathways with WTIP: view

Interacting Proteins for WTIP Gene

Gene Ontology (GO) - Biological Process for WTIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IDA 22286099
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0007010 cytoskeleton organization IMP 21834987
GO:0022604 regulation of cell morphogenesis IMP 21834987
genes like me logo Genes that share ontologies with WTIP: view

No data available for SIGNOR curated interactions for WTIP Gene

Drugs & Compounds for WTIP Gene

No Compound Related Data Available

Transcripts for WTIP Gene

mRNA/cDNA for WTIP Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WTIP Gene

Wilms tumor 1 interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WTIP Gene

No ASD Table

Relevant External Links for WTIP Gene

GeneLoc Exon Structure for
WTIP
ECgene alternative splicing isoforms for
WTIP

Expression for WTIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WTIP Gene

mRNA differential expression in normal tissues according to GTEx for WTIP Gene

This gene is overexpressed in Artery - Tibial (x6.3), Artery - Coronary (x5.0), and Artery - Aorta (x4.0).

Protein differential expression in normal tissues from HIPED for WTIP Gene

This gene is overexpressed in Adipocyte (42.2) and Bone marrow stromal cell (23.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WTIP Gene



Protein tissue co-expression partners for WTIP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WTIP Gene:

WTIP

SOURCE GeneReport for Unigene cluster for WTIP Gene:

Hs.585010
genes like me logo Genes that share expression patterns with WTIP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WTIP Gene

Orthologs for WTIP Gene

This gene was present in the common ancestor of animals.

Orthologs for WTIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WTIP 34 33
  • 99.37 (n)
OneToOne
cow
(Bos Taurus)
Mammalia WTIP 33 34
  • 90.23 (n)
rat
(Rattus norvegicus)
Mammalia Wtip 33
  • 88.78 (n)
dog
(Canis familiaris)
Mammalia WTIP 34
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wtip 34 16 33
  • 85.15 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WTIP 34
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WTIP 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves WTIP 34
  • 37 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii wtip 34
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta jub 34
  • 25 (a)
OneToMany
Species where no ortholog for WTIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WTIP Gene

ENSEMBL:
Gene Tree for WTIP (if available)
TreeFam:
Gene Tree for WTIP (if available)

Paralogs for WTIP Gene

Paralogs for WTIP Gene

(8) SIMAP similar genes for WTIP Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with WTIP: view

Variants for WTIP Gene

Sequence variations from dbSNP and Humsavar for WTIP Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000003338 -- 34,506,668(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000197923 -- 34,493,687(+) T/C intron_variant
rs1000378287 -- 34,503,796(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000429244 -- 34,503,634(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000472227 -- 34,487,594(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WTIP Gene

Variant ID Type Subtype PubMed ID
dgv6408n54 CNV gain 21841781
dgv6409n54 CNV gain 21841781
esv22345 CNV loss 19812545
nsv1059395 CNV gain 25217958
nsv1071532 CNV deletion 25765185
nsv1138698 CNV deletion 24896259
nsv1144873 CNV deletion 24896259
nsv517392 CNV gain+loss 19592680
nsv579347 CNV loss 21841781
nsv579349 CNV gain 21841781
nsv579357 CNV gain+loss 21841781

Variation tolerance for WTIP Gene

Gene Damage Index Score: 2.86; 48.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WTIP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WTIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WTIP Gene

Disorders for WTIP Gene

MalaCards: The human disease database

(2) MalaCards diseases for WTIP Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
wilms tumor 1
  • wt1
chromosome 19q13.11 deletion syndrome
  • 19q13.11 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search WTIP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WTIP

genes like me logo Genes that share disorders with WTIP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WTIP Gene

Publications for WTIP Gene

  1. A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus. (PMID: 14736876) Srichai MB … Sedor JR (The Journal of biological chemistry 2004) 2 3 22 58
  2. The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. (PMID: 22286099) Foxler DE … Sharp TV (Nature cell biology 2012) 3 4 58
  3. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. (PMID: 21834987) Bai SW … Ridley AJ (BMC biology 2011) 3 4 58
  4. Podocyte injury induces nuclear translocation of WTIP via microtubule-dependent transport. (PMID: 20086015) Kim JH … Sedor JR (The Journal of biological chemistry 2010) 3 4 58
  5. Ajuba LIM proteins are negative regulators of the Hippo signaling pathway. (PMID: 20303269) Das Thakur M … Longmore GD (Current biology : CB 2010) 3 4 58

Products for WTIP Gene

Sources for WTIP Gene

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