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WTIP Gene

protein-coding   GIFtS: 49
GCID: GC19P034971

Wilms Tumor 1 Interacting Protein

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Wilms Tumor 1 Interacting Protein1 2
WT1-Interacting Protein1 2 3
Wilms Tumor Protein 1-Interacting Protein2

External Ids:    HGNC: 209641   Entrez Gene: 1263742   Ensembl: ENSG000001422797   OMIM: 6147905   UniProtKB: A6NIX23   

Export aliases for WTIP gene to outside databases

Previous GC identifers: GC19P039665 GC19P039663 GC19P031481


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for WTIP Gene:
WTIP (Wilms tumor 1 interacting protein) is a protein-coding gene. An important paralog of this gene is LPP.

UniProtKB/Swiss-Prot: WTIP_HUMAN, A6NIX2
Function: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is
involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of
gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates
microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes
phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of
E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases
and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin
dynamics and/or foot process cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into
the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby
translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WTIP gene promoter:
         Sox5   HTF   FOXD3   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   c-Rel   POU2F1   POU2F1a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for WTIP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WTIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.11   Ensembl cytogenetic band:  19q13.11   HGNC cytogenetic band: 19q13.11

WTIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WTIP gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P034971:  view genomic region     (about GC identifiers)

Start:
34,971,874 bp from pter      End:
34,997,258 bp from pter
Size:
25,385 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: WTIP_HUMAN, A6NIX2 (See protein sequence)
Recommended Name: Wilms tumor protein 1-interacting protein  
Size: 430 amino acids; 45124 Da
Subunit: Forms homodimers (By similarity). Interacts with CD2AP and WT1. Interacts (via LIM domains) with SNAI1
(via SNAG domain), SNAI2/SLUG (via SNAG domain) and SCRT1 (via SNAG domain) (By similarity). Interacts with
EIF4E, AGO1, AGO2, DCP2, DDX6, LATS1, LATS2, SAV1, EGLN2/PHD1 and EGLN3/PHD3. Interacts (via LIM domains) with
isoform 1 and isoform 3 of VHL. Interacts with ROR2 (By similarity). Following treatment with bacterial
lipopolysaccharide (LPS), forms a complex with MAPK8IP3 and dynein intermediate chain (By similarity)

Explore the universe of human proteins at neXtProt for WTIP: NX_A6NIX2

Explore proteomics data for WTIP at MOPED


See WTIP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001073905.1  
ENSEMBL proteins: 
 ENSP00000466953   ENSP00000465683   ENSP00000270288  

WTIP Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for WTIP

 
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antibodies-online proteins for WTIP (3 products) 

 
antibodies-online peptides for WTIP

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antibodies-online antibodies for WTIP (11 products) 

WTIP Assay Products:

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antibodies-online kits for WTIP (3 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR001781 Znf_LIM

Graphical View of Domain Structure for InterPro Entry A6NIX2

ProtoNet protein and cluster: A6NIX2

UniProtKB/Swiss-Prot: WTIP_HUMAN, A6NIX2
Similarity: Belongs to the zyxin/ajuba family
Similarity: Contains 3 LIM zinc-binding domains


Find genes that share domains with WTIP           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: WTIP_HUMAN, A6NIX2
Function: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is
involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of
gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates
microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes
phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of
E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases
and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin
dynamics and/or foot process cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into
the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby
translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003714transcription corepressor activity IEA--
GO:0005515protein binding IPI--
GO:0008270zinc ion binding IEA--
     
Find genes that share ontologies with WTIP           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for WTIP:
 Increased 8N DNA content  Increased cell size 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for WTIP

miRNA
Products:
    
miRTarBase miRNAs that target WTIP:
hsa-mir-100-5p (MIRT048599), hsa-mir-615-3p (MIRT040083)

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Selected qRT-PCR Assays for microRNAs that regulate WTIP (see all 11):
hsa-miR-548am hsa-miR-224 hsa-miR-3133 hsa-miR-3647-3p hsa-miR-646 hsa-miR-186 hsa-miR-548x hsa-miR-3121-3p
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WTIP

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
WTIP_HUMAN, A6NIX2: Cell junction, adherens junction. Nucleus (By similarity). Cytoplasm, P-body. Note=Following
podocyte injury, caused by treatment with LPS, puromycin aminonucleoside, ultraviolet or hydrogen peroxide,
translocates from sites of cell-cell contacts into the cytosol and nucleus. The shift from cell contacts to
intracellular plaques starts as early as 1 hour after LPS stimulation and intranuclear localization begins 3
hours after LPS treatment. Maximal nuclear localization is achieved 6 hours after LPS treatment. Nuclear
translocation requires dynein motor activity and intact microtubule network (By similarity). Returns to cell-cell
contacts 24 hours after LPS stimulation. In the presence of ROR2, localizes to the plasma membrane (By
similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol3
nucleus3

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000932cytoplasmic mRNA processing body IDA--
GO:0005634nucleus IEA--
GO:0005912adherens junction IEA--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for WTIP About    
See pathways by source

SuperPathContained pathways About
1Hippo signaling pathway
Hippo signaling pathway


Find genes that share SuperPaths with WTIP           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



1 Kegg Pathway  (Kegg details for WTIP):
    Hippo signaling pathway

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WTIP
Interactions:

    Search GeneGlobe Interaction Network for WTIP

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

Selected Interacting proteins for WTIP (ENSP000002702884) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
InteractantInteraction Details
GeneCardExternal ID(s)
CD2APENSP000003522644STRING: ENSP00000352264
WT1ENSP000003313274STRING: ENSP00000331327
RARAENSP000002540664STRING: ENSP00000254066
EGLN2ENSP000003070804STRING: ENSP00000307080
EGLN3ENSP000002504574STRING: ENSP00000250457
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Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001666response to hypoxia IDA--
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated IEA--
GO:0007010cytoskeleton organization IMP--
GO:0022604regulation of cell morphogenesis IMP--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for WTIP



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for WTIP gene: 
NM_001080436.1  

Unigene Cluster for WTIP:

Wilms tumor 1 interacting protein
Hs.585010  [show with all ESTs]
Unigene Representative Sequence: NM_001080436
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000590071 ENST00000585928 ENST00000270288(uc002nvm.3)
miRNA
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Block miRNA regulation of human, mouse, rat WTIP using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate WTIP (see all 11):
hsa-miR-548am hsa-miR-224 hsa-miR-3133 hsa-miR-3647-3p hsa-miR-646 hsa-miR-186 hsa-miR-548x hsa-miR-3121-3p
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
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Predesigned siRNA for gene silencing in human, mouse, rat WTIP
Clone
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OriGene clones in human, mouse for WTIP (see all 5)
OriGene ORF clones in mouse, rat for WTIP
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: WTIP (NM_001080436)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for WTIP
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WTIP
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for WTIP
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WTIP
  QuantiTect SYBR Green Assays in human, mouse, rat WTIP
  QuantiFast Probe-based Assays in human, mouse, rat WTIP

Additional mRNA sequence: 

AK130059.1 BC030216.1 

4 DOTS entries:

DT.40290983  DT.212492  DT.99948993  DT.91876490 

1 AceView cDNA sequence:

BM711847 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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WTIP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGTGTTCCTG
WTIP Expression
About this image

WTIP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

WTIP Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.585010
    Custom PCR Arrays for WTIP
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for WTIP
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WTIP

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for WTIP gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Wtip1 , 5 WT1-interacting protein1, 5 85.15(n)1
90.2(a)1
  7 (19.40 cM)5
1015431  NM_207212.21  NP_997095.11 
 341095435 
chicken
(Gallus gallus)
Aves WTIP6
Wilms tumor 1 interacting protein
37(a)
1 ↔ 1
11(10526664-10597453)
zebrafish
(Danio rerio)
Actinopterygii wtip6
Wilms tumor 1 interacting protein
39(a)
1 ↔ 1
13(52035437-52091780) ENSDARG00000063666
fruit fly
(Drosophila melanogaster)
Insecta jub6
Ajuba LIM protein
25(a)
1 → many
X(13720363-13724347)


ENSEMBL Gene Tree for WTIP (if available)
TreeFam Gene Tree for WTIP (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for WTIP gene
LPP2  FBLIM12  TRIP62  ABLIM32  AJUBA2  DMTN2  ZYX2  ABLIM22  
LIMD12  ABLIM12  
8 SIMAP similar genes for WTIP using alignment to 2 protein entries:     WTIP_HUMAN (see all proteins):
AJUBA    LIMD1    LHX8    LMO3    LIMS1    ABLIM3
LHX4    LMO1

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for WTIP (see all 460)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1928279181,2
--34970909(+) TTATAC/TGACAC 1 -- us2k10--------
rs1837431161,2
--34970914(+) CGACAC/TGGTTG 1 -- us2k10--------
rs1886713881,2
C--34970915(+) GACACG/TGTTGT 1 -- us2k10--------
rs1932826251,2
--34970937(+) TGTCTC/GCATTT 1 -- us2k10--------
rs1842640721,2
--34971017(+) GGATGC/TTGACA 1 -- us2k10--------
rs1168311851,2
C--34971166(+) TGAACG/TGGCTT 1 -- us2k10--------
rs1884450801,2
--34971262(+) CGCACA/GGAGTC 1 -- us2k10--------
rs72575881,2
C,F--34971763(+) ACAGAC/TAACGG 1 -- us2k1 tfbs311Minor allele frequency- T:0.37NA WA CSA EA 374
rs43448661,2
C,F,A,H--34971846(+) GTCACT/CTCTCG 1 -- us2k122Minor allele frequency- C:0.41NS EA NA WA CSA 2348
rs72487051,2
C,F--34971998(+) GGCTCA/GCCGCC 1 -- us2k16Minor allele frequency- G:0.18NA WA CSA 11

HapMap Linkage Disequilibrium report for WTIP (34971874 - 34997258 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for WTIP:    About this table    
Variant IDTypeSubtypePubMed ID
esv22345CNV Loss19812545
nsv517392CNV Gain+Loss19592680

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing WTIP
DNA2.0 Custom Variant and Variant Library Synthesis for WTIP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 614790    OMIM disorders: --


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Genetic Association Database (GAD): WTIP

Export disorders for WTIP gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for WTIP gene, integrated from 10 sources (see all 14):
(articles sorted by number of sources associating them with WTIP)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus. (PubMed id 14736876)1, 3, 9 Srichai M.B....Sedor J.R. (J. Biol. Chem. 2004)
  2. The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. (PubMed id 22286099)1, 2 Foxler D.E.... Sharp T.V. (Nat. Cell Biol. 2012)
  3. Podocyte injury induces nuclear translocation of WTIP via microtubule-dependent transport. (PubMed id 20086015)1, 2 Kim J.H.... Sedor J.R. (J. Biol. Chem. 2010)
  4. WT1-interacting protein (Wtip) regulates podocyte phenotype by cell-cell and cell-matrix contact reorganization. (PubMed id 21900451)1 Kim J.H....Sedor J.R. (Am. J. Physiol. Renal Physiol. 2012)
  5. Out on a LIM: chronic kidney disease, podocyte phenotype and the Wilm's tumor interacting protein (WTIP). (PubMed id 21686224)1 Sedor J.R....Konieczkowski M. (Trans. Am. Clin. Climatol. Assoc. 2011)
  6. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PubMed id 21834987)2 Bai S.W.... Ridley A.J. (BMC Biol. 2011)
  7. Ajuba LIM proteins are negative regulators of the Hippo signaling pathway. (PubMed id 20303269)2 Das Thakur M....Longmore G.D. (Curr. Biol. 2010)
  8. LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. (PubMed id 20616046)2 James V.... Sharp T.V. (Proc. Natl. Acad. Sci. U.S.A. 2010)
  9. LIM protein Ajuba functions as a nuclear receptor corepressor and negatively regulates retinoic acid signaling. (PubMed id 20133701)1 Hou Z....Rauscher F.J. (Proc. Natl. Acad. Sci. U.S.A. 2010)
  10. The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling. (PubMed id 19785987)1 van Wijk N.V....Stricker S. (Biochem. Biophys. Res. Commun. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 126374 HGNC: 20964 AceView: WTIP.1 Ensembl:ENSG00000142279 euGenes: HUgn126374
ECgene: WTIP Kegg: 126374 H-InvDB: WTIP

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for WTIP Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for WTIP Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for WTIP gene:
Search GeneIP for patents involving WTIP

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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