Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WTIP Gene

protein-coding   GIFtS: 46
GCID: GC19P034971

Wilms tumor 1 interacting protein
 Explore 3 diseases affiliated with
WTIP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for WTIP    

Aliases
for WTIP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Wilms Tumor 1 Interacting Protein1 2
WT1-Interacting Protein2 3
Wilms Tumor Protein 1-Interacting Protein2

External Ids:    HGNC: 209641   Entrez Gene: 1263742   Ensembl: ENSG000001422797   OMIM: 6147905   UniProtKB: A6NIX23   

Export aliases for WTIP gene to outside databases

Previous GC identifers: GC19P039665 GC19P039663 GC19P031481


Summaries
for WTIP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: WTIP_HUMAN, A6NIX2
Function: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved
in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene
transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA
(miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1.
Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts
as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient
degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process
cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into the nucleus and acts as a
transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit
diaphragm structure into altered gene expression and a less differentiated phenotype




Genomic Views
for WTIP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WTIP gene promoter:
         Sox5   HTF   FOXD3   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   c-Rel   POU2F1   POU2F1a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for WTIP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WTIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.11   Ensembl cytogenetic band:  19q13.11   HGNC cytogenetic band: 19q13.11

WTIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WTIP gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P034971:  view genomic region     (about GC identifiers)

Start:
 34,971,793 bp from pter      End:
 34,997,258 bp from pter
Size:
 25,466 bases      Orientation:
 plus strand

Proteins
for WTIP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: WTIP_HUMAN, A6NIX2 (See protein sequence)
Recommended Name: Wilms tumor protein 1-interacting protein  
Size: 430 amino acids; 45124 Da
Subunit: Forms homodimers (By similarity). Interacts with CD2AP and WT1. Interacts (via LIM domains) with SNAI1 (via
SNAG domain), SNAI2/SLUG (via SNAG domain) and SCRT1 (via SNAG domain) (By similarity). Interacts with EIF4E, EIF2C1,
EIF2C2, DCP2, DDX6, LATS1, LATS2, SAV1, EGLN2/PHD1 and EGLN3/PHD3. Interacts (via LIM domains) with isoform 1 and
isoform 3 of VHL. Interacts with ROR2 (By similarity). Following treatment with bacterial lipopolysaccharide (LPS),
forms a complex with MAPK8IP3 and dynein intermediate chain (By similarity)
Subcellular location: Cell junction, adherens junction. Nucleus (By similarity). Cytoplasm, P-body. Note=Following
podocyte injury, caused by treatment with LPS, puromycin aminonucleoside, ultraviolet or hydrogen peroxide,
translocates from sites of cell-cell contacts into the cytosol and nucleus. The shift from cell contacts to
intracellular plaques starts as early as 1 hour after LPS stimulation and intranuclear localization begins 3 hours
after LPS treatment. Maximal nuclear localization is achieved 6 hours after LPS treatment. Nuclear translocation
requires dynein motor activity and intact microtubule network (By similarity). Returns to cell-cell contacts 24 hours
after LPS stimulation. In the presence of ROR2, localizes to the plasma membrane (By similarity)

Explore the universe of human proteins at neXtProt for WTIP: NX_A6NIX2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_A6NIX2

    • WTIP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001073905.1  
    ENSEMBL proteins: 
     ENSP00000466953   ENSP00000465683   ENSP00000270288  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: WTIP
    OriGene Protein Over-expression Lysate: WTIP
    OriGene Custom Protein Services for WTIP 
    GenScript Custom Purified and Recombinant Proteins Services for WTIP
    Novus Biologicals WTIP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for WTIP

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IDA--
    GO:0005634nucleus IEA--
    GO:0005912adherens junction IEA--


    WTIP for ontologies           About GeneDecksing



    WTIP Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for WTIP 
    GenScript Custom Superior Antibodies Services for WTIP
    Novus Biologicals WTIP Antibodies
    Search for Antibodies for WTIP at Abcam  
    Uscn Antibodies for WTIP
    Search ThermoFisher Antibodies for WTIP

    Assay Products for WTIP: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for WTIP
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for WTIP

    Protein Domains /
    Families
    for WTIP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    WTIP for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry A6NIX2

    ProtoNet protein and cluster: A6NIX2

    UniProtKB/Swiss-Prot: WTIP_HUMAN, A6NIX2
    Similarity: Belongs to the zyxin/ajuba family
    Similarity: Contains 3 LIM zinc-binding domains


    Function
    for WTIP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: WTIP_HUMAN, A6NIX2
    Function: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved
    in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene
    transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA
    (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1.
    Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts
    as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient
    degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process
    cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into the nucleus and acts as a
    transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit
    diaphragm structure into altered gene expression and a less differentiated phenotype

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WTIP
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate WTIP (see all 11):
    hsa-miR-548am hsa-miR-224 hsa-miR-3133 hsa-miR-3647-3p hsa-miR-646 hsa-miR-186 hsa-miR-548x hsa-miR-3121-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WTIP (see all 4)
    OriGene shRNA RFP: WTIP
    OriGene siRNA: WTIP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WTIP

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for WTIP

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WTIP (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WTIP
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: WTIP (NM_001080436)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WTIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WTIP 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for WTIP
    Search LifeMap BioReagents cell lines for WTIP

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WTIP

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity IEA--
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--


    WTIP for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for WTIP:
     Increased 8N DNA content  Increased cell size 


    Pathways & Interactions
    for WTIP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WTIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for WTIP (ENSP000002702884) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD2APENSP000003522644STRING: ENSP00000352264
    WT1ENSP000003313274STRING: ENSP00000331327
    RARAENSP000002540664STRING: ENSP00000254066
    EGLN3ENSP000002504574STRING: ENSP00000250457
    RAB4B-EGLN2ENSP000003070804STRING: ENSP00000307080
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IDA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0007010cytoskeleton organization IMP--
    GO:0022604regulation of cell morphogenesis IMP--


    WTIP for ontologies           About GeneDecksing



    Drugs & Compounds
    for WTIP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WTIP
    Search CenterWatch for drugs/clinical trials and news about WTIP 

    Transcripts
    for WTIP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for WTIP gene: 
    NM_001080436.1  

    Unigene Cluster for WTIP:

    Wilms tumor 1 interacting protein
    Hs.585010  [show with all ESTs]
    Unigene Representative Sequence: NM_001080436
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000590071 ENST00000585928 ENST00000270288(uc002nvm.3)

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WTIP
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate WTIP (see all 11):
    hsa-miR-548am hsa-miR-224 hsa-miR-3133 hsa-miR-3647-3p hsa-miR-646 hsa-miR-186 hsa-miR-548x hsa-miR-3121-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WTIP (see all 4)
    OriGene shRNA RFP: WTIP
    OriGene siRNA: WTIP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WTIP
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WTIP (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WTIP
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: WTIP (NM_001080436)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WTIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WTIP 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WTIP
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WTIP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WTIP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WTIP

    Additional cDNA sequence: 

    AK130059.1 BC030216.1 

    4 DOTS entries:

    DT.40290983  DT.212492  DT.99948993  DT.91876490 

    1 AceView cDNA sequence:

    BM711847 

    GeneLoc Exon Structure


    Expression
    for WTIP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WTIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGTGTTCCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    WTIP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See WTIP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WTIP

    SOURCE GeneReport for Unigene cluster: Hs.585010
        SABiosciences Custom PCR Arrays for WTIP
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WTIP
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WTIP
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WTIP
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WTIP
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WTIP

    Orthologs
    for WTIP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for WTIP gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves WTIP6
    		 Uncharacterized protein
    		 80(a)
    		 1 ↔ 1
    		 11(11854736-11938478)
    zebrafish
    (Danio rerio)    		 Actinopterygii wtip6
    		 Wilms tumor 1 interacting protein
    		 37(a)
    		 1 ↔ 1
    		 13(52035437-52091780)
    fruit fly
    (Drosophila melanogaster)    		 Insecta jub6
    		 Ajuba LIM protein
    		 26(a)
    		 1 → many
    		 X(13720363-13724347)
    worm
    (Caenorhabditis elegans)    		 Secernentea zyx-16
    		 ZYXin family member (zyx-1)
    		 14(a)
    		 1 → many
    		 II(13056744-13071460)


    ENSEMBL Gene Tree for WTIP (if available)
    TreeFam Gene Tree for WTIP (if available) 

    Paralogs
    for WTIP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WTIP gene
    LPP2  FBLIM12  TRIP62  AJUBA2  ZYX2  LIMD12  
    10 SIMAP similar genes for WTIP using alignment to 3 protein entries:     WTIP_HUMAN (see all proteins):
    AJUBA    LIMD1    LHX8    LHX6    LMO3    LIMS1
    ABLIM3    LHX4    LMO1    LHx4

    WTIP for paralogs           About GeneDecksing



    Genomic Variants
    for WTIP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/332 NCBI SNPs in WTIP are shown (see all 332)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1928279181,2
    		--34970909(+) TTATAC/TGACAC 1 -- us2k10--------
    rs1837431161,2
    		--34970914(+) CGACAC/TGGTTG 1 -- us2k10--------
    rs1886713881,2
    		--34970915(+) GACACG/TGTTGT 1 -- us2k10--------
    rs1932826251,2
    		--34970937(+) TGTCTC/GCATTT 1 -- us2k10--------
    rs1842640721,2
    		--34971017(+) GGATGC/TTGACA 1 -- us2k10--------
    rs1168311851,2
    		C,--34971166(+) TGAACG/TGGCTT 1 -- us2k10--------
    rs1884450801,2
    		--34971262(+) CGCACA/GGAGTC 1 -- us2k10--------
    rs72575881,2
    		C,F,--34971763(+) ACAGAC/TAACGG 1 -- us2k1 tfbs311Minor allele frequency- T:0.37NA WA CSA EA 374
    rs43448661,2
    		C,F,A,H,--34971846(+) GTCACT/CTCTCG 1 -- us2k122Minor allele frequency- C:0.41NS EA NA WA CSA 2348
    rs72487051,2
    		C,F,--34971998(+) GGCTCA/GCCGCC 1 -- us2k16Minor allele frequency- G:0.18NA WA CSA 11

    HapMap Linkage Disequilibrium report for WTIP (34971793 - 34997258 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for WTIP
         5 CNVs: 50131 50130 73360 50129 50128
         1 Indel: 40276

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WTIP
    DNA2.0 Custom Variant and Variant Library Synthesis for WTIP

    Disorders / Diseases
    for WTIP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    WTIP for disorders           About GeneDecksing

    OMIM gene information: 614790    OMIM disorders: --

    3 diseases for WTIP:    About MalaCards
    wilms tumor    kidney disease    hypoxia


    Export disorders for WTIP gene to outside databases

    Publications
    for WTIP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WTIP gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with WTIP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus. (PubMed id 14736876)1, 3, 9 Srichai M.B....Sedor J.R. (2004)
    2. The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. (PubMed id 22286099)1, 2 Foxler D.E.... Sharp T.V. (2012)
    3. Podocyte injury induces nuclear translocation of WTIP via microtubule-dependent transport. (PubMed id 20086015)1, 2 Kim J.H....Sedor J.R. (2010)
    4. WT1-interacting protein (Wtip) regulates podocyte phe notype by cell-cell and cell-matrix contact reorganization. (PubMed id 21900451)1 Kim J.H....Sedor J.R. (2012)
    5. Out on a LIM: chronic kidney disease, podocyte phenot ype and the Wilm's tumor interacting protein (WTIP). (PubMed id 21686224)1 Sedor J.R....Konieczkowski M. (2011)
    6. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PubMed id 21834987)2 Bai S.W.... Ridley A.J. (2011)
    7. Ajuba LIM proteins are negative regulators of the Hip po signaling pathway. (PubMed id 20303269)2 Das Thakur M....Longmore G.D. (2010)
    8. LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. (PubMed id 20616046)2 James V.... Sharp T.V. (2010)
    9. LIM protein Ajuba functions as a nuclear receptor cor epressor and negatively regulates retinoic acid signaling. (PubMed id 20133701)1 Hou Z....Rauscher F.J. (2010)
    10. The LIM domain protein Wtip interacts with the recept or tyrosine kinase Ror2 and inhibits canonical Wnt signalling. (PubMed id 19785987)1 van Wijk N.V....Stricker S. (2009)

    External Searches for WTIP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing WTIP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 126374 HGNC: 20964 AceView: WTIP.1 Ensembl:ENSG00000142279 euGenes: HUgn126374
    ECgene: WTIP H-InvDB: WTIP

    Other Databases showing WTIP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing WTIP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WTIP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WTIP Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for WTIP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for WTIP gene:
    Search GeneIP for patents involving WTIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for WTIP gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for WTIP  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WTIP   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WTIP  
     OriGene Protein Over-expression Lysate for WTIP   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for WTIP   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WTIP   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WTIP  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for WTIP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for WTIP   OriGene Custom Protein Services for WTIP  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WTIP
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WTIP
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WTIP
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WTIP
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WTIP
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WTIP
     GenScript Custom Purified and Recombinant Proteins Services for WTIP GenScript cDNA clones with any tag delivered in your preferred vector for WTIP
     GenScript Custom Assay Services for WTIP GenScript Custom Superior Antibodies Services for WTIP
     GenScript Custom overexpressing Cell Line Services for WTIP CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in WTIP promoter
     Search Chromatin IP Primers for WTIP
     RT2 qPCR Primer Assay in human, mouse, rat WTIP
     Search GNC Networks for WTIP
     SABiosciences Custom PCR Arrays for WTIP
     Search Tocris compounds for WTIP
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     WTIP antibodies
     WTIP lysates
     Search for Antibodies for WTIP at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for WTIP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     WTIP Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for WTIP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WTIP
     Browse SwitchGear 3'UTR luciferase reporter plasmids for WTIP
     Browse SwitchGear Promoter luciferase reporter plasmids for WTIP
     Search ThermoFisher Antibodies for WTIP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WTIP
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      WTIP gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4