External Ids for WTIP Gene
Previous GeneCards Identifiers for WTIP Gene
GeneCards Summary for WTIP Gene
WTIP (Wilms Tumor 1 Interacting Protein) is a Protein Coding gene. Diseases associated with WTIP include chromosome 19q13.11 deletion syndrome. Among its related pathways are Hippo signaling pathway. GO annotations related to this gene include transcription corepressor activity. An important paralog of this gene is AJUBA.
UniProtKB/Swiss-Prot for WTIP Gene
Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype.