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Aliases for WTAP Gene

Aliases for WTAP Gene

  • Wilms Tumor 1 Associated Protein 2 3 5
  • Wilms Tumor 1-Associating Protein 3 4
  • Female-Lethal(2)D Homolog 3 4
  • WT1-Associated Protein 3 4
  • HFL(2)D 3 4
  • Putative Pre-MRNA Splicing Regulator Female-Lethal(2D) 3
  • Wilms Tumour 1-Associating Protein 3
  • PNAS-132 3
  • KIAA0105 4
  • MUM2 3

External Ids for WTAP Gene

Previous GeneCards Identifiers for WTAP Gene

  • GC06P159587
  • GC06P160021
  • GC06P159981
  • GC06P160057
  • GC06P160118
  • GC06P157617
  • GC06P160146

Summaries for WTAP Gene

Entrez Gene Summary for WTAP Gene

  • The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in several transcript variants encoding three different isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for WTAP Gene

WTAP (Wilms Tumor 1 Associated Protein) is a Protein Coding gene. Diseases associated with WTAP include wilms tumor susceptibility-5. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway.

UniProtKB/Swiss-Prot for WTAP Gene

  • Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3 UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724).

Gene Wiki entry for WTAP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WTAP Gene

Genomics for WTAP Gene

Regulatory Elements for WTAP Gene

Genomic Location for WTAP Gene

Chromosome:
6
Start:
159,725,585 bp from pter
End:
159,756,319 bp from pter
Size:
30,735 bases
Orientation:
Plus strand

Genomic View for WTAP Gene

Genes around WTAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WTAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WTAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WTAP Gene

Proteins for WTAP Gene

  • Protein details for WTAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15007-FL2D_HUMAN
    Recommended name:
    Pre-mRNA-splicing regulator WTAP
    Protein Accession:
    Q15007
    Secondary Accessions:
    • Q5TCL8
    • Q5TCL9
    • Q96T28
    • Q9BYJ7
    • Q9H4E2

    Protein attributes for WTAP Gene

    Size:
    396 amino acids
    Molecular mass:
    44244 Da
    Quaternary structure:
    • Component of the WMM complex, a N6-methyltransferase complex composed of WTAP, METTL3 and METTL14 (PubMed:24407421, PubMed:24981863, PubMed:24316715). Interacts with WT1 (PubMed:11001926, PubMed:17095724). Component of the WTAP complex composed of WTAP, ZC3H13, CBLL1, KIAA1429, RBM15, BCLAF1 and THRAP3 (PubMed:24100041).

    Alternative splice isoforms for WTAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WTAP Gene

Proteomics data for WTAP Gene at MOPED

Post-translational modifications for WTAP Gene

  • Ubiquitination at Lys 83 and Lys 98
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for WTAP Gene

Domains & Families for WTAP Gene

Protein Domains for WTAP Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q15007

UniProtKB/Swiss-Prot:

FL2D_HUMAN :
  • Belongs to the fl(2)d family.
Family:
  • Belongs to the fl(2)d family.
genes like me logo Genes that share domains with WTAP: view

No data available for Gene Families for WTAP Gene

Function for WTAP Gene

Molecular function for WTAP Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3 UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724).
UniProtKB/Swiss-Prot Induction:
In smooth muscle cells, up-regulated after serum withdrawal, when cells become mature and non proliferative.
genes like me logo Genes that share phenotypes with WTAP: view

Animal Models for WTAP Gene

MGI Knock Outs for WTAP:
  • Wtap tm1a(EUCOMM)Hmgu

Animal Model Products

  • Taconic Biosciences Mouse Models for WTAP

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WTAP Gene

Localization for WTAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for WTAP Gene

Nucleus, nucleoplasm. Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WTAP Gene COMPARTMENTS Subcellular localization image for WTAP gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for WTAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0031965 nuclear membrane IDA 10942595
genes like me logo Genes that share ontologies with WTAP: view

Pathways & Interactions for WTAP Gene

genes like me logo Genes that share pathways with WTAP: view

Pathways by source for WTAP Gene

Gene Ontology (GO) - Biological Process for WTAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008380 RNA splicing IEA --
GO:0010467 gene expression TAS --
GO:0048024 regulation of mRNA splicing, via spliceosome IEA --
GO:0080009 mRNA methylation IMP 24316715
genes like me logo Genes that share ontologies with WTAP: view

No data available for SIGNOR curated interactions for WTAP Gene

Drugs & Compounds for WTAP Gene

No Compound Related Data Available

Transcripts for WTAP Gene

Unigene Clusters for WTAP Gene

Wilms tumor 1 associated protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WTAP Gene

No ASD Table

Relevant External Links for WTAP Gene

GeneLoc Exon Structure for
WTAP
ECgene alternative splicing isoforms for
WTAP

Expression for WTAP Gene

mRNA expression in normal human tissues for WTAP Gene

Protein differential expression in normal tissues from HIPED for WTAP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.7) and Lymph node (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WTAP Gene



SOURCE GeneReport for Unigene cluster for WTAP Gene Hs.446091

mRNA Expression by UniProt/SwissProt for WTAP Gene

Q15007-FL2D_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with WTAP: view

Protein tissue co-expression partners for WTAP Gene

- Elite partner

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for WTAP Gene

Orthologs for WTAP Gene

This gene was present in the common ancestor of animals.

Orthologs for WTAP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WTAP 35
  • 94.28 (n)
  • 95.2 (a)
WTAP 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WTAP 35
  • 95.45 (n)
  • 96.21 (a)
-- 36
  • 91 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Wtap 35
  • 93.77 (n)
  • 96.21 (a)
Wtap 16
Wtap 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WTAP 35
  • 99.75 (n)
  • 99.75 (a)
WTAP 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wtap 35
  • 93.92 (n)
  • 96.71 (a)
oppossum
(Monodelphis domestica)
Mammalia WTAP 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 85 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
chicken
(Gallus gallus)
Aves WTAP 35
  • 87.71 (n)
  • 91.67 (a)
WTAP 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WTAP 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wtap 35
  • 78.57 (n)
  • 83.93 (a)
zebrafish
(Danio rerio)
Actinopterygii wtap 35
  • 72.42 (n)
  • 79.38 (a)
wufi29a09 35
wtap 36
  • 71 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta fl(2)d 37
  • 54 (a)
fl(2)d 36
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7034 36
  • 57 (a)
OneToOne
Species with no ortholog for WTAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WTAP Gene

ENSEMBL:
Gene Tree for WTAP (if available)
TreeFam:
Gene Tree for WTAP (if available)

Paralogs for WTAP Gene

(1) SIMAP similar genes for WTAP Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for WTAP Gene

genes like me logo Genes that share paralogs with WTAP: view

No data available for Paralogs for WTAP Gene

Variants for WTAP Gene

Sequence variations from dbSNP and Humsavar for WTAP Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs35059844 - 159,743,771(-) TCTTG(C/G/T)TCCTT reference, missense
rs1440 -- 159,753,424(+) TTTTG(G/T)CTTCA intron-variant
rs763561 -- 159,745,858(+) ACAGA(A/G)TAGGT intron-variant
rs963800 -- 159,729,247(+) TTGTA(C/T)GTTAG intron-variant
rs911846 -- 159,744,747(-) GAGGC(C/T)CTGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WTAP Gene

Variant ID Type Subtype PubMed ID
dgv2023e1 CNV Complex 17122850

Variation tolerance for WTAP Gene

Residual Variation Intolerance Score: 23.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WTAP Gene

HapMap Linkage Disequilibrium report
WTAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WTAP Gene

Disorders for WTAP Gene

MalaCards: The human disease database

(1) MalaCards diseases for WTAP Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
wilms tumor susceptibility-5
  • wilms tumor
- elite association - COSMIC cancer census association via MalaCards
Search WTAP in MalaCards View complete list of genes associated with diseases

Relevant External Links for WTAP

Genetic Association Database (GAD)
WTAP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WTAP
genes like me logo Genes that share disorders with WTAP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WTAP Gene

Publications for WTAP Gene

  1. Identification of WTAP, a novel Wilms' tumour 1-associating protein. (PMID: 11001926) Little N.A. … Davies R.C. (Hum. Mol. Genet. 2000) 2 3 4 23 67
  2. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. (PMID: 24407421) Ping X.L. … Yang Y.G. (Cell Res. 2014) 2 3
  3. Nuclear degradation of Wilms tumor 1-associating protein and survivin splice variant switching underlie IGF-1-mediated survival. (PMID: 19605357) Small T.W. … Pickering J.G. (J. Biol. Chem. 2009) 3 23
  4. Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA. (PMID: 17088532) Horiuchi K. … Kodama T. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 23
  5. Wilms' tumor 1-associating protein regulates the proliferation of vascular smooth muscle cells. (PMID: 17095724) Small T.W. … Pickering J.G. (Circ. Res. 2006) 3 23

Products for WTAP Gene

Sources for WTAP Gene

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