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Aliases for WTAP Gene

Aliases for WTAP Gene

  • Wilms Tumor 1 Associated Protein 2 3
  • Wilms Tumor 1-Associating Protein 3 4
  • Female-Lethal(2)D Homolog 3 4
  • WT1-Associated Protein 3 4
  • HFL(2)D 3 4
  • Putative Pre-MRNA Splicing Regulator Female-Lethal(2D) 3
  • Wilms Tumour 1-Associating Protein 3
  • Pre-MRNA-Splicing Regulator WTAP 3
  • PNAS-132 3
  • KIAA0105 4
  • MUM2 3

External Ids for WTAP Gene

Previous GeneCards Identifiers for WTAP Gene

  • GC06P159587
  • GC06P160021
  • GC06P159981
  • GC06P160057
  • GC06P160118
  • GC06P157617
  • GC06P160146

Summaries for WTAP Gene

Entrez Gene Summary for WTAP Gene

  • The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in several transcript variants encoding three different isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for WTAP Gene

WTAP (Wilms Tumor 1 Associated Protein) is a Protein Coding gene. Diseases associated with WTAP include wilms tumor.

UniProtKB/Swiss-Prot for WTAP Gene

  • Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3 UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724).

Gene Wiki entry for WTAP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WTAP Gene

Genomics for WTAP Gene

Regulatory Elements for WTAP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WTAP Gene

Start:
159,725,585 bp from pter
End:
159,756,319 bp from pter
Size:
30,735 bases
Orientation:
Plus strand

Genomic View for WTAP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WTAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WTAP Gene

Proteins for WTAP Gene

  • Protein details for WTAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15007-FL2D_HUMAN
    Recommended name:
    Pre-mRNA-splicing regulator WTAP
    Protein Accession:
    Q15007
    Secondary Accessions:
    • Q5TCL8
    • Q5TCL9
    • Q96T28
    • Q9BYJ7
    • Q9H4E2

    Protein attributes for WTAP Gene

    Size:
    396 amino acids
    Molecular mass:
    44244 Da
    Quaternary structure:
    • Component of the WMM complex, a N6-methyltransferase complex composed of WTAP, METTL3 and METTL14 (PubMed:24316715, PubMed:24407421). Interacts with WT1 (PubMed:24316715, PubMed:24407421).

    Alternative splice isoforms for WTAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WTAP Gene

Proteomics data for WTAP Gene at MOPED

Post-translational modifications for WTAP Gene

  • Ubiquitination at Lys83 and Lys98
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for WTAP Gene

Domains for WTAP Gene

Protein Domains for WTAP Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q15007

UniProtKB/Swiss-Prot:

FL2D_HUMAN :
  • Q15007
Family:
  • Belongs to the fl(2)d family.
genes like me logo Genes that share domains with WTAP: view

No data available for Gene Families for WTAP Gene

Function for WTAP Gene

Molecular function for WTAP Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3 UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724).
UniProtKB/Swiss-Prot Induction:
In smooth muscle cells, up-regulated after serum withdrawal, when cells become mature and non proliferative

Gene Ontology (GO) - Molecular Function for WTAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with WTAP: view
genes like me logo Genes that share phenotypes with WTAP: view

Animal Model Products

miRNA for WTAP Gene

miRTarBase miRNAs that target WTAP

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WTAP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for WTAP Gene

Localization for WTAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for WTAP Gene

Nucleus, nucleoplasm. Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WTAP Gene COMPARTMENTS Subcellular localization image for WTAP gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for WTAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10942595
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IEA --
GO:0016607 nuclear speck IDA 24407421
GO:0031965 nuclear membrane IDA 10942595
genes like me logo Genes that share ontologies with WTAP: view

Pathways for WTAP Gene

SuperPathways for WTAP Gene

No Data Available

Gene Ontology (GO) - Biological Process for WTAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IMP 24407421
GO:0006397 mRNA processing IEA --
GO:0007049 cell cycle IEA --
GO:0008380 RNA splicing IEA --
GO:0080009 mRNA methylation IMP 24316715
genes like me logo Genes that share ontologies with WTAP: view

No data available for Pathways by source for WTAP Gene

Transcripts for WTAP Gene

Unigene Clusters for WTAP Gene

Wilms tumor 1 associated protein:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WTAP

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WTAP Gene

No ASD Table

Relevant External Links for WTAP Gene

GeneLoc Exon Structure for
WTAP
ECgene alternative splicing isoforms for
WTAP

Expression for WTAP Gene

mRNA expression in normal human tissues for WTAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for WTAP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.7) and Lymph node (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WTAP Gene

SOURCE GeneReport for Unigene cluster for WTAP Gene Hs.446091

mRNA Expression by UniProt/SwissProt for WTAP Gene

Q15007-FL2D_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with WTAP: view

Expression partners for WTAP Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for WTAP Gene

Orthologs for WTAP Gene

This gene was present in the common ancestor of animals.

Orthologs for WTAP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WTAP 35
  • 94.28 (n)
  • 95.2 (a)
WTAP 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WTAP 35
  • 95.45 (n)
  • 96.21 (a)
-- 36
  • 91 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Wtap 35
  • 93.77 (n)
  • 96.21 (a)
Wtap 16
Wtap 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WTAP 35
  • 99.75 (n)
  • 99.75 (a)
WTAP 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wtap 35
  • 93.92 (n)
  • 96.71 (a)
oppossum
(Monodelphis domestica)
Mammalia WTAP 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 85 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
chicken
(Gallus gallus)
Aves WTAP 35
  • 87.71 (n)
  • 91.67 (a)
WTAP 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WTAP 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wtap 35
  • 78.57 (n)
  • 83.93 (a)
zebrafish
(Danio rerio)
Actinopterygii wtap 35
  • 72.42 (n)
  • 79.38 (a)
wufi29a09 35
wtap 36
  • 71 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta fl(2)d 37
  • 54 (a)
fl(2)d 36
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7034 36
  • 57 (a)
OneToOne
Species with no ortholog for WTAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WTAP Gene

ENSEMBL:
Gene Tree for WTAP (if available)
TreeFam:
Gene Tree for WTAP (if available)

Paralogs for WTAP Gene

Selected SIMAP similar genes for WTAP Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for WTAP Gene

genes like me logo Genes that share paralogs with WTAP: view

No data available for Paralogs for WTAP Gene

Variants for WTAP Gene

Sequence variations from dbSNP and Humsavar for WTAP Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1440 -- 159,753,424(+) TTTTG(G/T)CTTCA intron-variant
rs763561 -- 159,745,858(+) ACAGA(A/G)TAGGT intron-variant
rs911846 -- 159,744,747(-) GAGGC(C/T)CTGTC intron-variant
rs963800 -- 159,729,247(+) TTGTA(C/T)GTTAG intron-variant
rs1042081 -- 159,749,323(+) TAAAA(A/G)AGCTT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for WTAP Gene

Variant ID Type Subtype PubMed ID
dgv2023e1 CNV Complex 17122850

Relevant External Links for WTAP Gene

HapMap Linkage Disequilibrium report
WTAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WTAP Gene

Disorders for WTAP Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for WTAP Gene in MalaCards »

(1) Diseases for WTAP Gene including...

(1) University of Copenhagen DISEASES for WTAP Gene

(1) Novoseek inferred disease relationships for WTAP Gene

Disease -log(P) Hits PubMed IDs
wilms tumor 77.3 12

Relevant External Links for WTAP

Genetic Association Database (GAD)
WTAP
genes like me logo Genes that share disorders with WTAP: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for WTAP Gene

Publications for WTAP Gene

  1. Identification of WTAP, a novel Wilms' tumour 1-associating protein. (PMID: 11001926) Little N.A. … Davies R.C. (Hum. Mol. Genet. 2000) 2 3 4 23
  2. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. (PMID: 24407421) Ping X.L. … Yang Y.G. (Cell Res. 2014) 2 3 4
  3. Biochemical function of female-lethal (2)D/Wilms' tumor suppressor-1- associated proteins in alternative pre-mRNA splicing. (PMID: 12444081) Ortega A. … Valcarcel J. (J. Biol. Chem. 2003) 3 4 23
  4. Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA. (PMID: 17088532) Horiuchi K. … Kodama T. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 23
  5. Wilms' tumor 1-associating protein regulates the proliferation of vascular smooth muscle cells. (PMID: 17095724) Small T.W. … Pickering J.G. (Circ. Res. 2006) 3 4 23

Products for WTAP Gene

  • Addgene plasmids for WTAP

Sources for WTAP Gene

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