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WTAP Gene

protein-coding   GIFtS: 58
GCID: GC06P160146

Wilms Tumor 1 Associated Protein

  See WTAP-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Wilms Tumor 1 Associated Protein1 2     PNAS-1322
Female-Lethal(2)D Homolog2 3     Pre-MRNA-Splicing Regulator WTAP2
Wilms Tumor 1-Associating Protein2 3     Putative Pre-MRNA Splicing Regulator Female-Lethal(2D)2
hFL(2)D2 3     Wilms' Tumour 1-Associating Protein2
WT1-Associated Protein2 3     KIAA01053

External Ids:    HGNC: 168461   Entrez Gene: 95892   Ensembl: ENSG000001464577   OMIM: 6054425   UniProtKB: Q150073   

Export aliases for WTAP gene to outside databases

Previous GC identifers: GC06P159587 GC06P160021 GC06P159981 GC06P160057 GC06P160118 GC06P157617


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WTAP Gene:
The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional
regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously
expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in
speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in several
transcript variants encoding three different isoforms. (provided by RefSeq, Jul 2012)

GeneCards Summary for WTAP Gene:
WTAP (Wilms tumor 1 associated protein) is a protein-coding gene. Diseases associated with WTAP include wilms tumor.

UniProtKB/Swiss-Prot: FL2D_HUMAN, Q15007
Function: Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates
N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency
of mRNA splicing and processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear
speckle. Acts as a mRNA splicing regulator. Regulates G2/M cell-cycle transition by binding to the 3' UTR of
CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes

Gene Wiki entry for WTAP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the WTAP gene promoter:
         HFH-1   MyoD   SEF-1 (1)   Ik-3   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): WTAP promoter sequence
   Search Chromatin IP Primers for WTAP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WTAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25-q27   Ensembl cytogenetic band:  6q25.3   HGNC cytogenetic band: 6q25-q27

WTAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WTAP gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P160146:  view genomic region     (about GC identifiers)

Start:
160,146,617 bp from pter      End:
160,177,351 bp from pter
Size:
30,735 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FL2D_HUMAN, Q15007 (See protein sequence)
Recommended Name: Pre-mRNA-splicing regulator WTAP  
Size: 396 amino acids; 44244 Da
Subunit: Component of the WMM complex, a N6-methyltransferase complex composed of WTAP, METTL3 and METTL14.
Interacts with WT1
Secondary accessions: Q5TCL8 Q5TCL9 Q96T28 Q9BYJ7 Q9H4E2
Alternative splicing: 2 isoforms:  Q15007-1   Q15007-2   

Explore the universe of human proteins at neXtProt for WTAP: NX_Q15007

Explore proteomics data for WTAP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys83, Lys98
  • Modification sites at PhosphoSitePlus

  • See WTAP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001257460.1  NP_001257461.1  NP_001257462.1  NP_004897.2  NP_690596.1  NP_690597.1  

    ENSEMBL proteins: 
     ENSP00000351141   ENSP00000336911  

    WTAP Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for WTAP
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    Cloud-Clone Corp. Proteins for WTAP

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q15007

    UniProtKB/Swiss-Prot: FL2D_HUMAN, Q15007
    Similarity: Belongs to the fl(2)d family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FL2D_HUMAN, Q15007
    Function: Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates
    N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency
    of mRNA splicing and processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear
    speckle. Acts as a mRNA splicing regulator. Regulates G2/M cell-cycle transition by binding to the 3' UTR of
    CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes
    Induction: In smooth muscle cells, up-regulated after serum withdrawal, when cells become mature and non
    proliferative

    Phenotypes:
         3 GenomeRNAi human phenotypes for WTAP:

     Decreased Salmonella enterica   Decreased Salmonella-containin  Decreased viability with cispl 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Wtap):
     behavior/neurological  embryogenesis  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging 

    Find genes that share phenotypes with WTAP           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WTAP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for WTAP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WTAP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WTAP

    miRNA
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    miRTarBase miRNAs that target WTAP:
    hsa-mir-124-3p (MIRT022388), hsa-mir-375 (MIRT019716)

    Block miRNA regulation of human, mouse, rat WTAP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WTAP (see all 85):
    hsa-miR-323-3p hsa-miR-642a hsa-miR-1224-3p hsa-miR-200a hsa-miR-938 hsa-miR-1260b hsa-miR-502-3p hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmidWTAP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat WTAP

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    Sino Biological Human cDNA Clone for WTAP
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FL2D_HUMAN, Q15007: Nucleus, nucleolus. Nucleus speckle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm ----
    GO:0005730NOT nucleolus IDA--
    GO:0016607nuclear speck IEA--
    GO:0031965nuclear membrane IDA10942595

    Find genes that share ontologies with WTAP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WTAP
    Interactions:

        GeneGlobe Interaction Network for WTAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WTAP (Q150072, 3 ENSP000003511414) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3MINT-3306625 I2D: score=1 
    MAGEA11P433642, 3, ENSP000003473584MINT-68213 I2D: score=5 STRING: ENSP00000347358
    WT1P195443, ENSP000003313274I2D: score=3 STRING: ENSP00000331327
    CENPAP494503, ENSP000003368684I2D: score=1 STRING: ENSP00000336868
    CPNE1Q998293, ENSP000003172574I2D: score=2 STRING: ENSP00000317257
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    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0007049cell cycle IEA--
    GO:0008380RNA splicing IEA--

    Find genes that share ontologies with WTAP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WTAP (FL2D)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WTAP gene (6 alternative transcripts): 
    NM_001270531.1  NM_001270532.1  NM_001270533.1  NM_004906.4  NM_152857.2  NM_152858.2  

    Unigene Cluster for WTAP:

    Wilms tumor 1 associated protein
    Hs.446091  [show with all ESTs]
    Unigene Representative Sequence: CR627456
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358372(uc003qsl.3 uc003qso.3) ENST00000494513 ENST00000337387(uc010kjx.3 uc003qsk.3 uc003qsn.3)
    ENST00000462110
    miRNA
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    Block miRNA regulation of human, mouse, rat WTAP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WTAP (see all 85):
    hsa-miR-323-3p hsa-miR-642a hsa-miR-1224-3p hsa-miR-200a hsa-miR-938 hsa-miR-1260b hsa-miR-502-3p hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmidWTAP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat WTAP
    Clone
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    OriGene ORF clones in mouse, rat for WTAP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): WTAP (NM_004906)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WTAP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WTAP
    Primer
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    OriGene qPCR primer pairs and template standards for WTAP
    OriGene qSTAR qPCR primer pairs in human, mouse for WTAP
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat WTAP
      QuantiTect SYBR Green Assays in human, mouse, rat WTAP
      QuantiFast Probe-based Assays in human, mouse, rat WTAP

    Additional mRNA sequence: 

    AF374416.1 AJ276706.1 AK127822.1 AK131393.1 AK290854.1 AL583911.1 BC000383.2 BC004432.1 
    BC028180.1 BC069192.1 CR627456.1 D14661.1 

    Selected DOTS entries (see all 30):

    DT.97763925  DT.99947916  DT.95234667  DT.432791  DT.121326884  DT.99985119  DT.121326948  DT.87046203 
    DT.100785468  DT.100785470  DT.100785473  DT.121326760  DT.444415  DT.121326845  DT.97799740  DT.121326957 
    DT.91642428  DT.100696281  DT.100676510  DT.75167872  DT.95078288  DT.121327067  DT.121327158  DT.100785472 

    Selected AceView cDNA sequences (see all 331):

    BU634057 AI300153 AL583911 BQ363865 AA743590 AI434767 CB044974 BE869234 
    CR622276 AA172208 AA810538 CA307364 AL559989 CR602734 CR602556 AJ276706 
    AI270361 AA461140 AU123639 CB243866 AA412316 BX419826 AA013174 AI123564 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WTAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTAAAAGAG
    WTAP Expression
    About this image


    WTAP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    WTAP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WTAP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.446091

    UniProtKB/Swiss-Prot: FL2D_HUMAN, Q15007
    Tissue specificity: Ubiquitously expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WTAP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WTAP gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wtap1 , 5 Wilms' tumour 1-associating protein5
    Wilms tumour 1-associating protein1
    93.77(n)1
    96.21(a)1
      17 (8.73 cM)5
    605321  NM_001113533.11  NP_001107005.11 
     129667965 
    chicken
    (Gallus gallus)
    Aves WTAP1 Wilms tumor 1 associated protein 87.71(n)
    91.67(a)
      421588  XM_004935575.1  XP_004935632.1 
    lizard
    (Anolis carolinensis)
    Reptilia WTAP6
    Wilms tumor 1 associated protein
    90(a)
    1 ↔ 1
    1(212216832-212237200)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ071392.12   -- 83.91(n)    BJ071392.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi29a092 wufi29a09 77.89(n)   334058  BC055544.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fl(2)d3 primary sex determination, soma 54(a)   2 50C6   --


    ENSEMBL Gene Tree for WTAP (if available)
    TreeFam Gene Tree for WTAP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WTAP gene
    1 SIMAP similar gene for WTAP using alignment to 1 protein entry:     FL2D_HUMAN:
    DKFZp686F20131

    Find genes that share paralogs with WTAP           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for WTAP
    PGOHUM00000242880 PGOHUM00000243190


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WTAP (see all 727)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs797596131,2
    C,F--160146099(+) GCTCCG/CGGACT 3 -- us2k12Minor allele frequency- C:0.14CSA WA 120
    rs779949871,2
    F--160146109(+) TTTAGT/CATGCA 3 -- us2k11Minor allele frequency- C:0.03WA 118
    rs94577121,2
    C,F,H--160146224(+) AGCTCG/AGAGGG 3 -- us2k19Minor allele frequency- A:0.21NA WA CSA EA 369
    rs1812256261,2
    C--160146227(+) TCAGAA/GGGGCC 3 -- us2k10--------
    rs27583581,2
    C,F--160146294(+) GATCAC/ACTGAG 3 -- us2k1 tfbs35Minor allele frequency- A:0.35NA WA EA 244
    rs1138463111,2
    C--160146318(+) GACCAG/TCCTGG 3 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1863679551,2
    --160146433(+) GCTTGA/GACCCA 3 -- us2k10--------
    rs119610251,2
    H--160146474(+) caccaA/Ctgcac 3 -- us2k10--------
    rs2010241941,2
    --160146542(+) AATTA-/TTTTTT 6 -- us2k10--------
    rs94577131,2
    C,F,A,H--160146552(+) TTCTGT/GGTATC 6 -- us2k15Minor allele frequency- G:0.35WA NA EA 362

    HapMap Linkage Disequilibrium report for WTAP (160146617 - 160177351 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for WTAP:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2023e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WTAP
    DNA2.0 Custom Variant and Variant Library Synthesis for WTAP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605442    OMIM disorders: --

    1 disease for WTAP:    
    About MalaCards
    wilms tumor

    1 disease from the University of Copenhagen DISEASES database for WTAP:
    Nephroblastoma

    Find genes that share disorders with WTAP           About GenesLikeMe

    1 Novoseek inferred disease relationship for WTAP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wilms tumor 77.3 17 17936204 (4), 17088532 (2), 17095724 (2), 16990779 (1) (see all 7)

    Genetic Association Database (GAD): WTAP

    Export disorders for WTAP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WTAP gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with WTAP)
        Utopia: connect your pdf to the dynamic
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    1. Identification of WTAP, a novel Wilms' tumour 1-associating protein. (PubMed id 11001926)1, 2, 3, 9 Little N.A.... Davies R.C. (Hum. Mol. Genet. 2000)
    2. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527)1, 2, 3 Nagase T.... Nomura N. (DNA Res. 1995)
    3. Wilms' tumor 1-associating protein regulates the proliferation of vascular smooth muscle cells. (PubMed id 17095724)1, 2, 9 Small T.W.... Pickering J.G. (Circ. Res. 2006)
    4. Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA. (PubMed id 17088532)1, 2, 9 Horiuchi K....Kodama T. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    5. Biochemical function of female-lethal (2)D/Wilms' tumor suppressor-1- associated proteins in alternative pre-mRNA splicing. (PubMed id 12444081)1, 2, 9 Ortega A....Valcarcel J. (J. Biol. Chem. 2003)
    6. Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. (PubMed id 19084217)1, 4 Benyamin B....Visscher P.M. (Am. J. Hum. Genet. 2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Nuclear degradation of Wilms tumor 1-associating protein and survivin splice variant switching underlie IGF-1-mediated survival. (PubMed id 19605357)1, 9 Small T.W. and Pickering J.G. (J. Biol. Chem. 2009)
    9. A METTL3-METTL14 complex mediates mammalian nuclear RNA N-adenosine methylation. (PubMed id 24316715)2 Liu J.... He C. (Nat. Chem. Biol. 2014)
    10. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. (PubMed id 24407421)2 Ping X.L.... Yang Y.G. (Cell Res. 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9589 HGNC: 16846 AceView: WTAP Ensembl:ENSG00000146457 euGenes: HUgn9589
    ECgene: WTAP H-InvDB: WTAP

    (According to HUGE)
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    HUGE: KIAA0105

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WTAP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WTAP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WTAP gene:
    Search GeneIP for patents involving WTAP

    GeneCards and IP:
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