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Aliases for WTAP Gene

Aliases for WTAP Gene

  • Wilms Tumor 1 Associated Protein 2 3 5
  • Wilms Tumor 1-Associating Protein 3 4
  • Female-Lethal(2)D Homolog 3 4
  • WT1-Associated Protein 3 4
  • HFL(2)D 3 4
  • Putative Pre-MRNA Splicing Regulator Female-Lethal(2D) 3
  • Wilms Tumour 1-Associating Protein 3
  • Pre-MRNA-Splicing Regulator WTAP 3
  • PNAS-132 3
  • KIAA0105 4
  • MUM2 3

External Ids for WTAP Gene

Previous GeneCards Identifiers for WTAP Gene

  • GC06P159587
  • GC06P160021
  • GC06P159981
  • GC06P160057
  • GC06P160118
  • GC06P157617
  • GC06P160146

Summaries for WTAP Gene

Entrez Gene Summary for WTAP Gene

  • The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in several transcript variants encoding three different isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for WTAP Gene

WTAP (Wilms Tumor 1 Associated Protein) is a Protein Coding gene. Diseases associated with WTAP include Wilms Tumor Susceptibility-5. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression.

UniProtKB/Swiss-Prot for WTAP Gene

  • Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3 UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724).

Gene Wiki entry for WTAP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WTAP Gene

Genomics for WTAP Gene

Regulatory Elements for WTAP Gene

Enhancers for WTAP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F159714 1.6 FANTOM5 Ensembl ENCODE 26.6 -9.3 -9257 3.6 PKNOX1 ARNT MLX ARID4B DMAP1 YY1 ZNF143 FOS SP5 MXD4 IGF2R MRPL18 WTAP SOD2 PNLDC1 HNRNPH1P1 RNU4ATAC18P
GH06F159690 0.7 ENCODE 23.3 -32.2 -32186 5.8 HDGF PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 MRPL18 WTAP PNLDC1 SOD2 ACAT2 SNORA29 TCP1 SNORA20 ENSG00000237927 GC06M159698
GH06F159759 0.2 ENCODE 22.6 +36.0 36003 4.0 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 MRPL18 WTAP PNLDC1 ACAT2 LOC100129518
GH06F159699 1 Ensembl ENCODE 21.9 -24.6 -24601 3.5 YY1 FOS SP3 REST TSHZ1 ZNF518A ZNF623 SMARCA4 MYNN STAT3 MRPL18 WTAP PNLDC1 SOD2 ACAT2 SNORA29 TCP1 GC06M159698 PIR54448 GC06M159668
GH06F159972 1.4 FANTOM5 ENCODE 18.8 +248.1 248124 3.0 PKNOX1 ARNT CREB3L1 ARID4B FEZF1 DMAP1 ZNF48 YY1 GATA2 FOS IGF2R WTAP SOD2 LOC729603 SLC22A1 MAS1 AIRN
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around WTAP on UCSC Golden Path with GeneCards custom track

Genomic Location for WTAP Gene

Chromosome:
6
Start:
159,725,585 bp from pter
End:
159,756,319 bp from pter
Size:
30,735 bases
Orientation:
Plus strand

Genomic View for WTAP Gene

Genes around WTAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WTAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WTAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WTAP Gene

Proteins for WTAP Gene

  • Protein details for WTAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15007-FL2D_HUMAN
    Recommended name:
    Pre-mRNA-splicing regulator WTAP
    Protein Accession:
    Q15007
    Secondary Accessions:
    • Q5TCL8
    • Q5TCL9
    • Q96T28
    • Q9BYJ7
    • Q9H4E2

    Protein attributes for WTAP Gene

    Size:
    396 amino acids
    Molecular mass:
    44244 Da
    Quaternary structure:
    • Component of the WMM complex, a N6-methyltransferase complex composed of WTAP, METTL3 and METTL14 (PubMed:24407421, PubMed:24981863, PubMed:24316715). Interacts with WT1 (PubMed:11001926, PubMed:17095724). Component of the WTAP complex composed of WTAP, ZC3H13, CBLL1, KIAA1429, RBM15, BCLAF1 and THRAP3 (PubMed:24100041).

    Alternative splice isoforms for WTAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WTAP Gene

Post-translational modifications for WTAP Gene

  • Ubiquitination at Lys 83 and Lys 98
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for WTAP

No data available for DME Specific Peptides for WTAP Gene

Domains & Families for WTAP Gene

Protein Domains for WTAP Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q15007

UniProtKB/Swiss-Prot:

FL2D_HUMAN :
  • Belongs to the fl(2)d family.
Family:
  • Belongs to the fl(2)d family.
genes like me logo Genes that share domains with WTAP: view

No data available for Gene Families for WTAP Gene

Function for WTAP Gene

Molecular function for WTAP Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3 UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724).
UniProtKB/Swiss-Prot Induction:
In smooth muscle cells, up-regulated after serum withdrawal, when cells become mature and non proliferative.

Gene Ontology (GO) - Molecular Function for WTAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with WTAP: view
genes like me logo Genes that share phenotypes with WTAP: view

Animal Model Products

  • Taconic Biosciences Mouse Models for WTAP

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WTAP Gene

Localization for WTAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for WTAP Gene

Nucleus, nucleoplasm. Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WTAP Gene COMPARTMENTS Subcellular localization image for WTAP gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for WTAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10942595
GO:0005654 nucleoplasm TAS --
GO:0016607 nuclear speck IEA,IDA 24100041
GO:0031965 nuclear membrane IDA 10942595
GO:0036396 MIS complex IDA 24316715
genes like me logo Genes that share ontologies with WTAP: view

Pathways & Interactions for WTAP Gene

genes like me logo Genes that share pathways with WTAP: view

Pathways by source for WTAP Gene

Gene Ontology (GO) - Biological Process for WTAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IMP 24407421
GO:0006397 mRNA processing IEA --
GO:0007049 cell cycle IEA --
GO:0008380 RNA splicing IEA --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with WTAP: view

No data available for SIGNOR curated interactions for WTAP Gene

Transcripts for WTAP Gene

Unigene Clusters for WTAP Gene

Wilms tumor 1 associated protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WTAP Gene

No ASD Table

Relevant External Links for WTAP Gene

GeneLoc Exon Structure for
WTAP
ECgene alternative splicing isoforms for
WTAP

Expression for WTAP Gene

mRNA expression in normal human tissues for WTAP Gene

Protein differential expression in normal tissues from HIPED for WTAP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.7) and Lymph node (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WTAP Gene



Protein tissue co-expression partners for WTAP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WTAP Gene:

WTAP

SOURCE GeneReport for Unigene cluster for WTAP Gene:

Hs.446091

mRNA Expression by UniProt/SwissProt for WTAP Gene:

Q15007-FL2D_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with WTAP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for WTAP Gene

Orthologs for WTAP Gene

This gene was present in the common ancestor of animals.

Orthologs for WTAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WTAP 34 35
  • 99.75 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 98 (a)
OneToMany
-- 35
  • 85 (a)
OneToMany
-- 35
  • 85 (a)
OneToMany
dog
(Canis familiaris)
Mammalia WTAP 34
  • 95.45 (n)
-- 35
  • 95 (a)
OneToMany
-- 35
  • 94 (a)
OneToMany
-- 35
  • 92 (a)
OneToMany
-- 35
  • 91 (a)
OneToMany
cow
(Bos Taurus)
Mammalia WTAP 34 35
  • 94.28 (n)
oppossum
(Monodelphis domestica)
Mammalia WTAP 35
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wtap 34
  • 93.92 (n)
mouse
(Mus musculus)
Mammalia Wtap 34 16 35
  • 93.77 (n)
chicken
(Gallus gallus)
Aves WTAP 34 35
  • 87.71 (n)
lizard
(Anolis carolinensis)
Reptilia WTAP 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wtap 34
  • 78.57 (n)
zebrafish
(Danio rerio)
Actinopterygii wtap 34 35
  • 72.42 (n)
wufi29a09 34
fruit fly
(Drosophila melanogaster)
Insecta fl(2)d 36 35
  • 54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7034 35
  • 57 (a)
OneToOne
Species where no ortholog for WTAP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WTAP Gene

ENSEMBL:
Gene Tree for WTAP (if available)
TreeFam:
Gene Tree for WTAP (if available)

Paralogs for WTAP Gene

(1) SIMAP similar genes for WTAP Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for WTAP Gene

genes like me logo Genes that share paralogs with WTAP: view

No data available for Paralogs for WTAP Gene

Variants for WTAP Gene

Sequence variations from dbSNP and Humsavar for WTAP Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1042081 -- 159,749,323(+) TAAAA(A/G)AGCTT intron-variant, utr-variant-3-prime
rs10440817 -- 159,730,290(+) TTTTC(C/G)TTCAG intron-variant
rs10455779 -- 159,736,873(+) ACATC(A/G)TCTCT intron-variant
rs1048018 -- 159,726,604(-) ACTCC(C/T)TGAAG intron-variant, upstream-variant-2KB
rs1048019 -- 159,726,598(+) GTCTT(A/G)CTTCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for WTAP Gene

Variant ID Type Subtype PubMed ID
esv2759483 CNV gain 17122850
nsv949879 CNV duplication 24416366
nsv981201 CNV duplication 23825009

Variation tolerance for WTAP Gene

Residual Variation Intolerance Score: 23.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WTAP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WTAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WTAP Gene

Disorders for WTAP Gene

MalaCards: The human disease database

(1) MalaCards diseases for WTAP Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
wilms tumor susceptibility-5
  • wilms tumor
- elite association - COSMIC cancer census association via MalaCards
Search WTAP in MalaCards View complete list of genes associated with diseases

Relevant External Links for WTAP

Genetic Association Database (GAD)
WTAP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WTAP
genes like me logo Genes that share disorders with WTAP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WTAP Gene

Publications for WTAP Gene

  1. Identification of WTAP, a novel Wilms' tumour 1-associating protein. (PMID: 11001926) Little N.A. … Davies R.C. (Hum. Mol. Genet. 2000) 2 3 4 22 64
  2. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. (PMID: 24407421) Ping X.L. … Yang Y.G. (Cell Res. 2014) 2 3 4 64
  3. Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA. (PMID: 17088532) Horiuchi K. … Kodama T. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 22 64
  4. Wilms' tumor 1-associating protein regulates the proliferation of vascular smooth muscle cells. (PMID: 17095724) Small T.W. … Pickering J.G. (Circ. Res. 2006) 3 4 22 64
  5. Biochemical function of female-lethal (2)D/Wilms' tumor suppressor-1- associated proteins in alternative pre-mRNA splicing. (PMID: 12444081) Ortega A. … Valcarcel J. (J. Biol. Chem. 2003) 3 4 22 64

Products for WTAP Gene

Sources for WTAP Gene

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