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Aliases for WT1-AS Gene

Subcategory (RNA class) for WT1-AS Gene

lncRNA

Quality Score for this RNA gene is

3

Aliases for WT1-AS Gene

  • WT1 Antisense RNA 2 3
  • WT1 Antisense RNA (Non-Protein Coding) 2 3
  • Wilms Tumor Upstream Neighbor 1 2 3
  • Wilms Tumor Associated Protein 2 3
  • WIT-1 3 4
  • WIT1 3 4
  • Wilms Tumor-Associated Antisense RNA 4
  • WT1-AS1 3
  • WT1AS 3

External Ids for WT1-AS Gene

Previous HGNC Symbols for WT1-AS Gene

  • WIT1

Previous GeneCards Identifiers for WT1-AS Gene

  • GC11P032459

Summaries for WT1-AS Gene

Entrez Gene Summary for WT1-AS Gene

  • This gene is located upstream of the Wilms tumor 1 (WT1) gene; these two genes are bi-directionally transcribed from the same promoter region. This gene is imprinted in kidney, with preferential expression from the paternal allele. Imprinting defects at chromosome 11p13 may contribute to tumorigenesis. [provided by RefSeq, May 2014]

GeneCards Summary for WT1-AS Gene

WT1-AS (WT1 Antisense RNA) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with WT1-AS include wilms tumor and focal segmental glomerulosclerosis.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WT1-AS Gene

Genomics for WT1-AS Gene

Genomic Location for WT1-AS Gene

Start:
32,435,518 bp from pter
End:
32,458,769 bp from pter
Size:
23,252 bases
Orientation:
Plus strand

Genomic View for WT1-AS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WT1-AS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WT1-AS Gene

No data available for Regulatory Elements for WT1-AS Gene

Proteins for WT1-AS Gene

  • Protein details for WT1-AS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06250-WIT1_HUMAN
    Recommended name:
    Putative Wilms tumor upstream neighbor 1 gene protein
    Protein Accession:
    Q06250
    Secondary Accessions:
    • Q4KMY0
    • Q96A27

    Protein attributes for WT1-AS Gene

    Size:
    92 amino acids
    Molecular mass:
    10039 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA49572.1; Type=Frameshift; Positions=83; Evidence={ECO:0000305};

neXtProt entry for WT1-AS Gene

Proteomics data for WT1-AS Gene at MOPED

Post-translational modifications for WT1-AS Gene

No Post-translational modifications

No data available for DME Specific Peptides for WT1-AS Gene

Domains for WT1-AS Gene

Gene Families for WT1-AS Gene

HGNC:
  • LNCRNA :Long non-coding RNAs

Protein Domains for WT1-AS Gene

ProtoNet:

Suggested Antigen Peptide Sequences for WT1-AS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WT1-AS: view

No data available for UniProtKB/Swiss-Prot for WT1-AS Gene

Function for WT1-AS Gene

Gene Ontology (GO) - Molecular Function for WT1-AS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with WT1-AS: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WT1-AS

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for WT1-AS Gene

Localization for WT1-AS Gene

Gene Ontology (GO) - Cellular Components for WT1-AS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with WT1-AS: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for WT1-AS Gene

Pathways for WT1-AS Gene

SuperPathways for WT1-AS Gene

No Data Available

Gene Ontology (GO) - Biological Process for WT1-AS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with WT1-AS: view

No data available for Pathways by source for WT1-AS Gene

Transcripts for WT1-AS Gene

Unigene Clusters for WT1-AS Gene

WT1 antisense RNA:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WT1-AS

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for WT1-AS
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WT1-AS Gene

No ASD Table

Relevant External Links for WT1-AS Gene

GeneLoc Exon Structure for
WT1-AS
ECgene alternative splicing isoforms for
WT1-AS

Expression for WT1-AS Gene

mRNA expression in normal human tissues for WT1-AS Gene

mRNA differential expression in normal tissues according to GTEx for WT1-AS Gene

This gene is overexpressed in Ovary (13.7), Uterus (8.7), Fallopian Tube (6.2), and Cervix - Ectocervix (4.2).

SOURCE GeneReport for Unigene cluster for WT1-AS Gene Hs.567499

genes like me logo Genes that share expressions with WT1-AS: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for WT1-AS Gene

Orthologs for WT1-AS Gene

Evolution for WT1-AS Gene

ENSEMBL:
Gene Tree for WT1-AS (if available)
TreeFam:
Gene Tree for WT1-AS (if available)

No data available for Orthologs for WT1-AS Gene

Paralogs for WT1-AS Gene

No data available for Paralogs for WT1-AS Gene

Variants for WT1-AS Gene

Sequence variations from dbSNP and Humsavar for WT1-AS Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs6508 - 32,438,918(+) ATGTG(A/G)CGTTG nc-transcript-variant, downstream-variant-500B, intron-variant
rs975665 -- 32,441,830(-) ATTTA(G/T)CCAGA intron-variant
rs2073187 -- 32,442,314(-) CTAAG(C/G)TTGAT intron-variant
rs2418912 -- 32,452,131(+) AAAAA(C/G)GTGGG nc-transcript-variant
rs2900742 -- 32,441,828(+) GGTCT(A/G)GATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WT1-AS Gene

Variant ID Type Subtype PubMed ID
nsv832108 CNV Loss 17160897

Relevant External Links for WT1-AS Gene

HapMap Linkage Disequilibrium report
WT1-AS
Human Gene Mutation Database (HGMD)
WT1-AS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WT1-AS Gene

Disorders for WT1-AS Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for WT1-AS Gene including...

Search for WT1-AS Gene in MalaCards »
genes like me logo Genes that share disorders with WT1-AS: view

No data available for UniProtKB/Swiss-Prot for WT1-AS Gene

Publications for WT1-AS Gene

  1. Tissue, developmental, and tumor-specific expression of divergent transcripts in Wilms tumor. (PMID: 2173145) Huang A. … Williams B.R. (Science 1990) 2 3 4
  2. Sequence of the WT1 upstream region including the Wit-1 gene. (PMID: 8406502) Gassler M. … Bruns G.A.P. (Genomics 1993) 2 3 4
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 3 4
  4. A CTCF-binding silencer regulates the imprinted genes AWT1 and WT1-AS and exhibits sequential epigenetic defects during Wilms' tumourigenesis. (PMID: 17210670) Hancock A.L. … Malik K. (Hum. Mol. Genet. 2007) 2 3
  5. Cloning of novel Wilms tumor gene (WT1) cDNAs; evidence for antisense transcription of WT1. (PMID: 8208551) Eccles M.R. … Reeve A.E. (Oncogene 1994) 3 23

Products for WT1-AS Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate WT1-AS
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for WT1-AS
    • Block miRNA regulation of WT1-AS using miScript Target Protectors

    Sources for WT1-AS Gene

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