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Aliases for WT1 Gene

Aliases for WT1 Gene

  • Wilms Tumor 1 2 3
  • NPHS4 3 6
  • WT33 3 4
  • Last Three Zinc Fingers Of The DNA-Binding Domain Of WT1 3
  • Amino-Terminal Domain Of EWS 3
  • Wilms Tumor Protein 3
  • EWS-WT1 3
  • WIT-2 3
  • AWT1 3
  • WAGR 3
  • GUD 3

External Ids for WT1 Gene

Previous HGNC Symbols for WT1 Gene

  • GUD

Previous GeneCards Identifiers for WT1 Gene

  • GC11M034005
  • GC11U900002
  • GC11M032448
  • GC11M032373
  • GC11M032104

Summaries for WT1 Gene

Entrez Gene Summary for WT1 Gene

  • This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]

GeneCards Summary for WT1 Gene

WT1 (Wilms Tumor 1) is a Protein Coding gene. Diseases associated with WT1 include wilms tumor and denys-drash syndrome. Among its related pathways are Integrated Pancreatic Cancer Pathway and Transcriptional misregulation in cancer. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is EGR1.

UniProtKB/Swiss-Prot for WT1 Gene

  • Transcription factor that plays an important role in cellular development and cell survival. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. Recognizes and binds to the DNA sequence 5-CGCCCCCGC-3. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA.

Gene Wiki entry for WT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WT1 Gene

Genomics for WT1 Gene

Regulatory Elements for WT1 Gene

Transcription factor binding sites by QIAGEN in the WT1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WT1 Gene

Start:
32,387,775 bp from pter
End:
32,435,630 bp from pter
Size:
47,856 bases
Orientation:
Minus strand

Genomic View for WT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WT1 Gene

Proteins for WT1 Gene

  • Protein details for WT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19544-WT1_HUMAN
    Recommended name:
    Wilms tumor protein
    Protein Accession:
    P19544
    Secondary Accessions:
    • A8K6S1
    • B3KSA5
    • Q15881
    • Q16256
    • Q16575
    • Q4VXV4
    • Q4VXV5
    • Q4VXV6
    • Q8IYZ5

    Protein attributes for WT1 Gene

    Size:
    449 amino acids
    Molecular mass:
    49188 Da
    Quaternary structure:
    • Homodimer. Interacts with WTIP. Interacts with actively translating polysomes. Detected in nuclear ribonucleoprotein (mRNP) particles. Interacts with HNRNPU via the zinc-finger region. Interacts with U2AF2. Interacts with CITED2 (By similarity). Interacts with ZNF224 via the zinc-finger region. Interacts with WTAP and SRY. Interacts with AMER1. Interacts with RBM4.
    Miscellaneous:
    • Presence of the KTS motif hinders interactions between DNA and zinc-finger 4
    SequenceCaution:
    • Sequence=AAB33443.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=CAA35956.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA35956.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=CAC39220.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI95758.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI95759.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for WT1 Gene

    Alternative splice isoforms for WT1 Gene

neXtProt entry for WT1 Gene

Proteomics data for WT1 Gene at MOPED

Post-translational modifications for WT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for WT1 (WT1)

No data available for DME Specific Peptides for WT1 Gene

Domains for WT1 Gene

Gene Families for WT1 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Graphical View of Domain Structure for InterPro Entry

P19544

UniProtKB/Swiss-Prot:

WT1_HUMAN :
  • P19544
Family:
  • Belongs to the EGR C2H2-type zinc-finger protein family.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with WT1: view

Function for WT1 Gene

Molecular function for WT1 Gene

GENATLAS Biochemistry:
Wilms tumor protein including WIT1 overlapping 5 - WT1 and divergently (antisense) transcribed sequences,transcriptional regulator binding to both GC-rich and TC repeat elements that are present in multiple promoters,first considered as a repressor but appearing now as a transcriptional activator of specific genes i.e AMH,DAX1 implicated in gonadal differentiation,highly expressed in the developing kidney located in the condensing mesenchyme,renal vesicle,developing podocytes and also expressed in urogenital tract,sometimes paternally imprinted in placenta and fetal brain but maternally imprinted in fibroblasts and lymphocytes,overexpressed in myelodysplastic syndrome in progression and in acute leukemia
UniProtKB/Swiss-Prot Function:
Transcription factor that plays an important role in cellular development and cell survival. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. Recognizes and binds to the DNA sequence 5-CGCCCCCGC-3. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA.

Gene Ontology (GO) - Molecular Function for WT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription ISS --
GO:0003676 nucleic acid binding --
GO:0003690 double-stranded DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 7862533
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with WT1: view
genes like me logo Genes that share phenotypes with WT1: view

Animal Models for WT1 Gene

MGI Knock Outs for WT1:

Animal Model Products

miRNA for WT1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WT1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for WT1 Gene

Localization for WT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WT1 Gene

Nucleus. Nucleus, nucleolus. Cytoplasm. Note=Shuttles between nucleus and cytoplasm. {ECO:0000250}.
Isoform 1: Nucleus speckle.
Isoform 4: Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WT1 Gene COMPARTMENTS Subcellular localization image for WT1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
extracellular 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for WT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 14701728
GO:0005654 nucleoplasm IDA 15520190
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm ISS --
GO:0016607 nuclear speck IDA 15520190
genes like me logo Genes that share ontologies with WT1: view

Pathways for WT1 Gene

genes like me logo Genes that share pathways with WT1: view

Pathways by source for WT1 Gene

1 KEGG pathway for WT1 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for WT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 7585606
GO:0001570 vasculogenesis ISS --
GO:0001656 metanephros development --
GO:0001657 ureteric bud development ISS --
GO:0001658 branching involved in ureteric bud morphogenesis IGI 10101119
genes like me logo Genes that share ontologies with WT1: view

Compounds for WT1 Gene

(49) Novoseek inferred chemical compound relationships for WT1 Gene

Compound -log(P) Hits PubMed IDs
zinc 73.4 151
b 723 53.5 11
dmrt 49.2 1
gemtuzumab ozogamicin 44.6 2
estrogen 26 29
genes like me logo Genes that share compounds with WT1: view

Transcripts for WT1 Gene

Unigene Clusters for WT1 Gene

Wilms tumor 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WT1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WT1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - - -
SP2: - -
SP3: - - -
SP4: - - - - -
SP5: - - -
SP6:

Relevant External Links for WT1 Gene

GeneLoc Exon Structure for
WT1
ECgene alternative splicing isoforms for
WT1

Expression for WT1 Gene

mRNA expression in normal human tissues for WT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WT1 Gene

This gene is overexpressed in Uterus (11.7), Fallopian Tube (8.7), Ovary (7.7), and Testis (4.4).

Protein differential expression in normal tissues for WT1 Gene

This gene is overexpressed in Fetal ovary (29.4), Fetal testis (27.2), and Ovary (12.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WT1 Gene

SOURCE GeneReport for Unigene cluster for WT1 Gene Hs.591980

mRNA Expression by UniProt/SwissProt for WT1 Gene

P19544-WT1_HUMAN
Tissue specificity: Expressed in the kidney and a subset of hematopoietic cells
genes like me logo Genes that share expressions with WT1: view

Expression partners for WT1 Gene

In Situ Assay Products

Orthologs for WT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WT1 35
  • 93.84 (n)
  • 99.34 (a)
WT1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WT1 35
  • 93.42 (n)
  • 98.2 (a)
WT1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wt1 35
  • 89.35 (n)
  • 93.89 (a)
Wt1 16
Wt1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WT1 35
  • 98.57 (n)
  • 98.92 (a)
WT1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wt1 35
  • 91.54 (n)
  • 97.75 (a)
oppossum
(Monodelphis domestica)
Mammalia WT1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WT1 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves WT1 35
  • 83.25 (n)
  • 91.26 (a)
WT1 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WT1 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wt1 35
  • 77.86 (n)
  • 86.13 (a)
African clawed frog
(Xenopus laevis)
Amphibia wt1-A 35
zebrafish
(Danio rerio)
Actinopterygii wt1 35
wt1a 35
  • 73.92 (n)
  • 78.48 (a)
wt1a 36
  • 77 (a)
OneToMany
wt1b 36
  • 69 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5 35
fruit fly
(Drosophila melanogaster)
Insecta CG3065 36
  • 19 (a)
ManyToMany
klu 36
  • 12 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea egrh-1 36
  • 20 (a)
OneToMany
egrh-2 36
  • 22 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIG2 36
  • 11 (a)
ManyToMany
MIG3 36
  • 10 (a)
ManyToMany
-- 38
-- 38
Species with no ortholog for WT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WT1 Gene

ENSEMBL:
Gene Tree for WT1 (if available)
TreeFam:
Gene Tree for WT1 (if available)

Paralogs for WT1 Gene

Paralogs for WT1 Gene

genes like me logo Genes that share paralogs with WT1: view

Variants for WT1 Gene

Sequence variations from dbSNP and Humsavar for WT1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs16754 -- 32,396,399(-) GTGCG(A/G)CGTGT reference, synonymous-codon
rs1042347 -- 32,388,238(-) TGGGA(C/G)TGTCC utr-variant-3-prime
rs1569776 -- 32,400,431(-) CAGTG(C/T)ACTTA intron-variant
rs1799933 -- 32,427,940(-) GCTGG(A/G)CTCTG intron-variant
rs1799934 -- 32,400,446(-) AGGTG(C/T)CGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WT1 Gene

Variant ID Type Subtype PubMed ID
nsv832108 CNV Loss 17160897
esv273806 CNV Insertion 20981092
esv271370 CNV Insertion 20981092

Relevant External Links for WT1 Gene

HapMap Linkage Disequilibrium report
WT1
Human Gene Mutation Database (HGMD)
WT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WT1 Gene

Disorders for WT1 Gene

(6) OMIM Diseases for WT1 Gene (607102)

UniProtKB/Swiss-Prot

WT1_HUMAN
  • Frasier syndrome (FS) [MIM:136680]: Characterized by a slowly progressing nephropathy leading to renal failure in adolescence or early adulthood, male pseudohermaphroditism, and no Wilms tumor. As for histological findings of the kidneys, focal glomerular sclerosis is often observed. There is phenotypic overlap with Denys-Drash syndrome. Inheritance is autosomal dominant. {ECO:0000269 PubMed:10571943}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Wilms tumor 1 (WT1) [MIM:194070]: Embryonal malignancy of the kidney that affects approximately 1 in 10000 infants and young children. It occurs both in sporadic and hereditary forms. {ECO:0000269 PubMed:1317572, ECO:0000269 PubMed:15150775, ECO:0000269 PubMed:9108089, ECO:0000269 PubMed:9529364}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Denys-Drash syndrome (DDS) [MIM:194080]: Typical nephropathy characterized by diffuse mesangial sclerosis, genital abnormalities, and/or Wilms tumor. There is phenotypic overlap with WAGR syndrome and Frasier syndrome. Inheritance is autosomal dominant, but most cases are sporadic. {ECO:0000269 PubMed:10738002, ECO:0000269 PubMed:10799199, ECO:0000269 PubMed:11182928, ECO:0000269 PubMed:11519891, ECO:0000269 PubMed:1302008, ECO:0000269 PubMed:1338906, ECO:0000269 PubMed:15349765, ECO:0000269 PubMed:1655284, ECO:0000269 PubMed:8111391, ECO:0000269 PubMed:8112732, ECO:0000269 PubMed:8295405, ECO:0000269 PubMed:8388765, ECO:0000269 PubMed:8411073, ECO:0000269 PubMed:8741319, ECO:0000269 PubMed:8956030, ECO:0000269 PubMed:9475094, ECO:0000269 PubMed:9529364}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Nephrotic syndrome 4 (NPHS4) [MIM:256370]: A form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure. Most patients with NPHS4 show diffuse mesangial sclerosis on renal biopsy, which is a pathologic entity characterized by mesangial matrix expansion with no mesangial hypercellularity, hypertrophy of the podocytes, vacuolized podocytes, thickened basement membranes, and diminished patency of the capillary lumen. {ECO:0000269 PubMed:11182928, ECO:0000269 PubMed:15253707, ECO:0000269 PubMed:9529364, ECO:0000269 PubMed:9607189}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Meacham syndrome (MEACHS) [MIM:608978]: Rare sporadically occurring multiple malformation syndrome characterized by male pseudohermaphroditism with abnormal internal female genitalia comprising a uterus and double or septate vagina, complex congenital heart defect and diaphragmatic abnormalities. {ECO:0000269 PubMed:17853480}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=A chromosomal aberration involving WT1 may be a cause of desmoplastic small round cell tumor (DSRCT). Translocation t(11;22)(p13;q12) with EWSR1.
  • Mesothelioma, malignant (MESOM) [MIM:156240]: An aggressive neoplasm of the serosal lining of the chest. It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. {ECO:0000269 PubMed:8401592}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

(89) Novoseek inferred disease relationships for WT1 Gene

Disease -log(P) Hits PubMed IDs
wilms tumor 98.2 284
denys-drash syndrome 96.9 96
frasier syndrome 95.4 51
wagr syndrome 92.2 28
mesangial sclerosis, diffuse 91.4 22

Relevant External Links for WT1

GeneTests
WT1
GeneReviews
WT1
Genetic Association Database (GAD)
WT1
Human Genome Epidemiology (HuGE) Navigator
WT1
Tumor Gene Database (TGDB):
WT1
genes like me logo Genes that share disorders with WT1: view

No data available for Genatlas for WT1 Gene

Publications for WT1 Gene

  1. Germline mutations in the Wilms' tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome. (PMID: 1655284) Pelletier J. … Housman D.E. (Cell 1991) 3 4 23 48
  2. A novel mutation H373Y in the Wilms' tumor suppressor gene, WT1, associated with Denys-Drash syndrome. (PMID: 8956030) Ghahremani M. … Pelletier J. (Hum. Hered. 1996) 3 4 23 48
  3. Twenty-four new cases of WT1 germline mutations and review of the literature: genotype/phenotype correlations for Wilms tumor development. (PMID: 15150775) Royer-Pokora B. … Huff V. (Am. J. Med. Genet. A 2004) 3 4 23 48
  4. Mutation analysis of five candidate genes in Chinese patients with hypospadias. (PMID: 15266301) Wang Y. … Shen Y. (Eur. J. Hum. Genet. 2004) 3 4 23 48
  5. Prevalence of WT1 mutations in a large cohort of patients with steroid-resistant and steroid-sensitive nephrotic syndrome. (PMID: 15253707) Ruf R.G. … Hildebrandt F. (Kidney Int. 2004) 3 4 23 48

Products for WT1 Gene

  • Addgene plasmids for WT1

Sources for WT1 Gene

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