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WT1 Gene

protein-coding   GIFtS: 70
GCID: GC11M032365

Wilms Tumor 1


(Previous symbol: GUD)
  See WT1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Wilms Tumor 11 2     WAGR2
GUD1 2     WIT-22
WT332 3     Amino-Terminal Domain Of EWS2
NPHS42 5     Last Three Zinc Fingers Of The DNA-Binding Domain Of WT12
AWT12     Wilms Tumor Protein2
EWS-WT12     

External Ids:    HGNC: 127961   Entrez Gene: 74902   Ensembl: ENSG000001849377   OMIM: 6071025   UniProtKB: P195443   

Export aliases for WT1 gene to outside databases

Previous GC identifers: GC11M034005 GC11U900002 GC11M032448 GC11M032373 GC11M032104


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WT1 Gene:
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a
proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development
of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. This gene exhibits
complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the
maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several
variants, there is evidence for the use of a non-AUG (CUG) translation initiation site upstream of and in-frame
with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human
and rat, and that this process is tissue-restricted and developmentally regulated. (provided by RefSeq, Oct 2010)

GeneCards Summary for WT1 Gene:
WT1 (Wilms tumor 1) is a protein-coding gene. Diseases associated with WT1 include wt1-related disorders, and denys-drash syndrome. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is EGR3.

UniProtKB/Swiss-Prot: WT1_HUMAN, P19544
Function: Transcription factor that plays an important role in cellular development and cell survival. Regulates
the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital
system. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'. It has a tumor suppressor as well as an
oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as
transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or
splicing. Isoform 1 has lower affinity for DNA, and can bind RNA

Gene Wiki entry for WT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the WT1 gene promoter:
         TBP   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): WT1 promoter sequence
   Search Chromatin IP Primers for WT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13   Ensembl cytogenetic band:  11p13   HGNC cytogenetic band: 11p13

WT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WT1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M032365:  view genomic region     (about GC identifiers)

Start:
32,409,321 bp from pter      End:
32,457,176 bp from pter
Size:
47,856 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: WT1_HUMAN, P19544 (See protein sequence)
Recommended Name: Wilms tumor protein  
Size: 449 amino acids; 49188 Da
Subunit: Homodimer. Interacts with WTIP. Interacts with actively translating polysomes. Detected in nuclear
ribonucleoprotein (mRNP) particles. Interacts with HNRNPU via the zinc-finger region. Interacts with U2AF2.
Interacts with CITED2 (By similarity). Interacts with ZNF224 via the zinc-finger region. Interacts with WTAP and
SRY. Interacts with AMER1. Interacts with RBM4
Rna editing: Modified_positions=281; Note=Partially edited
Miscellaneous: Presence of the KTS motif hinders interactions between DNA and zinc-finger 4
Sequence caution: Sequence=AAB33443.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of
unknown origin in the N-terminal part; Sequence=CAA35956.1; Type=Erroneous initiation; Note=Translation
N-terminally shortened; Sequence=CAA35956.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The
initiator methionine is coded by a non-canonical CTG leucine codon; Sequence=CAC39220.3; Type=Erroneous
initiation; Note=Translation N-terminally shortened; Sequence=CAI95758.2; Type=Erroneous initiation;
Note=Translation N-terminally shortened; Sequence=CAI95759.2; Type=Erroneous initiation; Note=Translation
N-terminally shortened;
Selected PDB 3D structures from and Proteopedia for WT1 (see all 11):
1LU6 (3D)        1XF7 (3D)        2G7T (3D)        2G7V (3D)        2G7W (3D)        2G7X (3D)    
Secondary accessions: A8K6S1 B3KSA5 Q15881 Q16256 Q16575 Q4VXV4 Q4VXV5 Q4VXV6 Q8IYZ5
Alternative splicing, Alternative initiation: 8 isoforms:  P19544-1   P19544-2   P19544-3   P19544-4   P19544-6   P19544-7   P19544-8   P19544-9   
(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WT1: NX_P19544

Explore proteomics data for WT1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See WT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_000369.3  NP_001185480.1  NP_001185481.1  NP_077742.2  NP_077744.3  

    ENSEMBL proteins: 
     ENSP00000368370   ENSP00000368368   ENSP00000331327   ENSP00000435307   ENSP00000415516  
     ENSP00000413452   ENSP00000435624   ENSP00000436292   ENSP00000435351  

    WT1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for WT1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for WT1
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    Novus Biologicals WT1 Proteins
    Novus Biologicals WT1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WT1

     
    Search eBioscience for Proteins for WT1 

     
    antibodies-online proteins for WT1 (5 products) 

     
    antibodies-online peptides for WT1

    WT1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of WT1
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    Novus Biologicals WT1 Antibodies
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    antibodies-online antibodies for WT1 (89 products) 

    WT1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for WT1
    Cloud-Clone Corp. CLIAs for WT1
    Search eBioscience for ELISAs for WT1 
    antibodies-online kits for WT1 (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    5 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR000976 Wilms_tumour_N
     IPR017987 Wilms_tumour
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P19544

    ProtoNet protein and cluster: P19544

    2 Blocks protein domains:
    IPB000976 Wilm's tumour protein signature
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: WT1_HUMAN, P19544
    Similarity: Belongs to the EGR C2H2-type zinc-finger protein family
    Similarity: Contains 4 C2H2-type zinc fingers


    Find genes that share domains with WT1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WT1_HUMAN, P19544
    Function: Transcription factor that plays an important role in cellular development and cell survival. Regulates
    the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital
    system. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'. It has a tumor suppressor as well as an
    oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as
    transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or
    splicing. Isoform 1 has lower affinity for DNA, and can bind RNA

         Genatlas biochemistry entry for WT1:
    Wilms tumor protein including WIT1 overlapping 5' - WT1 and divergently (antisense) transcribed
    sequences,transcriptional regulator binding to both GC-rich and TC repeat elements that are present in multiple
    promoters,first considered as a repressor but appearing now as a transcriptional activator of specific genes i.e
    AMH,DAX1 implicated in gonadal differentiation,highly expressed in the developing kidney located in the
    condensing mesenchyme,renal vesicle,developing podocytes and also expressed in urogenital tract,sometimes
    paternally imprinted in placenta and fetal brain but maternally imprinted in fibroblasts and
    lymphocytes,overexpressed in myelodysplastic syndrome in progression and in acute leukemia

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription ISS--
    GO:0003676nucleic acid binding ----
    GO:0003690double-stranded DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity NAS7862533
    GO:0003723RNA binding IEA--
         
    Find genes that share ontologies with WT1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for WT1:
     Decreased sensitivity to pacli 

         Selected MGI mutant phenotypes (inferred from 17 alleles(MGI details for Wt1) (see all 16):
     cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system  mortality/aging 
     muscle  no phenotypic analysis  normal  renal/urinary system  reproductive system 

    Find genes that share phenotypes with WT1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for WT1: Wt1tm2Hst Wt1tm1.1Jak Wt1tm2.1Vih Wt1tm1Jak Wt1tm1Jae Wt1tm1Hst

       genOway: Develop your customized and physiologically relevant rodent model for WT1

    miRNA
    Products:
        
    miRTarBase miRNAs that target WT1:
    hsa-mir-212-3p (MIRT003966), hsa-mir-15a-5p (MIRT000817), hsa-mir-16-5p (MIRT000816)

    Block miRNA regulation of human, mouse, rat WT1 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate WT1:
    hsa-miR-498 hsa-miR-3690 hsa-miR-361-5p hsa-miR-657 hsa-miR-29a* hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidWT1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for WT1
    Predesigned siRNA for gene silencing in human, mouse, rat WT1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for WT1

    Clone
    Products:
         
    OriGene clones in human, mouse for WT1 (see all 29)
    OriGene ORF clones in mouse, rat for WT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): WT1 (NM_000378)
    Sino Biological Human cDNA Clone for WT1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WT1
    Addgene plasmids for WT1 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WT1

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12570) for WT1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WT1_HUMAN, P19544: Nucleus. Nucleus, nucleolus. Cytoplasm (By similarity). Note=Shuttles between nucleus and
    cytoplasm (By similarity)
    WT1_HUMAN, P19544: Isoform 1: Nucleus speckle
    WT1_HUMAN, P19544: Isoform 4: Nucleus, nucleoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    cytosol2
    extracellular2
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm IDA15520190
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ISS--
    GO:0016607nuclear speck IDA15520190

    Find genes that share ontologies with WT1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WT1 About    
    See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    2Regulation of Telomerase
    Regulation of Telomerase
    3Integrated Pancreatic Cancer Pathway
    Integrated Pancreatic Cancer Pathway


    Find genes that share SuperPaths with WT1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for WT1
        Integrated Pancreatic Cancer Pathway
    Regulation of Telomerase



    1 Kegg Pathway  (Kegg details for WT1):
        Transcriptional misregulation in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WT1 (see all 6): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for WT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WT1 (P195442, 3 ENSP000003313274) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF205O952012, 3MINT-8277163 I2D: score=2 
    AREGP155143, ENSP000002644874I2D: score=1 STRING: ENSP00000264487
    DVL3Q929972, 3, ENSP000003160544MINT-8277130 I2D: score=3 STRING: ENSP00000316054
    NPM3O756072, 3, ENSP000003591284MINT-8277141 I2D: score=2 STRING: ENSP00000359128
    TAOK1Q7L7X32, 3, ENSP000002617164MINT-8277152 I2D: score=2 STRING: ENSP00000261716
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 50):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA7585606
    GO:0001570vasculogenesis ISS--
    GO:0001656metanephros development ----
    GO:0001657ureteric bud development ISS--
    GO:0001658branching involved in ureteric bud morphogenesis IGI10101119

    Find genes that share ontologies with WT1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WT1

    Selected Novoseek inferred chemical compound relationships for WT1 gene (see all 49)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 73.4 250 8196623 (6), 8875984 (6), 12640038 (6), 19123921 (4) (see all 99)
    b 723 53.5 11 12883236 (3), 16415794 (2), 14652817 (1), 18318582 (1) (see all 8)
    dmrt 49.2 1 16868052 (1)
    gemtuzumab ozogamicin 44.6 2 17562618 (1), 18621416 (1)
    estrogen 26 33 20204298 (3), 16087727 (2), 18567994 (2), 18469708 (1) (see all 25)
    progesterone 24.7 24 14662165 (6), 17182656 (2), 11739471 (1), 18469708 (1) (see all 15)
    paraffin 21.6 10 15648285 (2), 11954027 (1), 11688464 (1), 17115439 (1) (see all 8)
    imatinib 21.3 35 15329907 (5), 19580340 (4), 19624538 (3), 17728783 (3) (see all 7)
    retinoic acid 15.4 23 8875981 (3), 15855632 (3), 7700638 (2), 8142654 (2) (see all 12)
    oligonucleotide 13.4 20 11721364 (4), 8649791 (3), 11601276 (1), 10607714 (1) (see all 8)



    Find genes that share compounds with WT1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WT1 gene (6 alternative transcripts): 
    NM_000378.4  NM_001198551.1  NM_001198552.1  NM_024424.3  NM_024426.4  NM_024425.2  

    Unigene Cluster for WT1:

    Wilms tumor 1
    Hs.591980  [show with all ESTs]
    Unigene Representative Sequence: BC046461
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379079(uc001mtl.2) ENST00000379077(uc009yjs.2) ENST00000332351(uc001mtn.2 uc001mto.2 uc001mtq.2)
    ENST00000530998(uc001mtm.2) ENST00000452863 ENST00000448076 ENST00000527882
    ENST00000526685 ENST00000527775
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate WT1:
    hsa-miR-498 hsa-miR-3690 hsa-miR-361-5p hsa-miR-657 hsa-miR-29a* hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidWT1 3' UTR sequence
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WT1
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      QuantiFast Probe-based Assays in human, mouse, rat WT1
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    Additional mRNA sequence: 

    AK093168.1 AK291736.1 BC032861.2 BC046461.1 M30393.1 S74529.1 S75264.1 X51630.1 

    10 DOTS entries:

    DT.100018186  DT.412611  DT.95346595  DT.100741611  DT.102836170  DT.100765578  DT.91944366  DT.120758147 
    DT.95361679  DT.97793050 

    Selected AceView cDNA sequences (see all 27):

    CR604547 BU633051 NM_015855 BV196067 BX394943 BM543913 BX110205 CB267195 
    BC002734 AI951613 T54801 L25110 AW028595 BM906117 BM545678 AI648530 
    BE394437 M60614 CA430691 AW194904 BX387534 AA912908 BX390192 AI803567 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for WT1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
    SP1:              -                       -           -                                             
    SP2:              -                                   -                                             
    SP3:                                      -           -                             -               
    SP4:              -                       -     -     -                             -               
    SP5:                                      -     -     -                                             


    ECgene alternative splicing isoforms for WT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGTATATG
    WT1 Expression
    About this image


    WT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Kidney (Urinary System)    fully expand to see all 20 entries
             Proximal Renal Vesicle Cells Renal Vesicle
             Metanephros
             mK4
             Podocalyxin+, CD24+, GCTM2-
     
     Ovary (Reproductive System)    fully expand to see all 10 entries
             Pre-Granulosa Cells Primordial Follicle
             Secondary Follicle
             Secondary follicles
             visceral organ/ovary/ruptured follicle   
     
     Intermediate Mesoderm (Gastrulation Derivatives)    fully expand to see all 3 entries
             Intermediate Mesoderm Cells Intermediate Mesoderm
             Intermediate mesoderm-like cells
     
     Heart (Cardiovascular System)    fully expand to see all 5 entries
             Epicardial Progenitors Cells Epicardium
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Gonad Somatic Cells Primitive Gonad
    WT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591980

    UniProtKB/Swiss-Prot: WT1_HUMAN, P19544
    Tissue specificity: Expressed in the kidney and a subset of hematopoietic cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WT1 (see all 6): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              p53 Signaling Pathway in human mouse rat
              Embryonic Stem Cells in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for WT1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wt11 , 5 Wilms tumor 1 homolog1, 5 89.35(n)1
    93.89(a)1
      2 (55.06 cM)5
    224311  NM_144783.21  NP_659032.31 
     1051265295 
    chicken
    (Gallus gallus)
    Aves WT11 Wilms tumor 1 83.25(n)
    91.26(a)
      396139  NM_205216.1  NP_990547.1 
    lizard
    (Anolis carolinensis)
    Reptilia WT16
    Wilms tumor 1
    91(a)
    1 ↔ 1
    1(61119049-61163167)
    African clawed frog
    (Xenopus laevis)
    Amphibia wt1-A2 Wilms tumor 1 77.48(n)    U42011.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wt12 wilms tumor 75.54(n)   30245  AF144550.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG30656
    klu6
    klumpfuss
    19(a)
    12(a)
    many ↔ many
    many ↔ many
    2R(19857830-19859756)
    3L(10974271-11001933)
    worm
    (Caenorhabditis elegans)
    Secernentea egrh-26
    egrh-16
    Protein EGRH-1 (egrh-1) mRNA, complete cds
    22(a)
    20(a)
    1 ↔ many
    1 ↔ many
    IV(984711-990439) WBGene00043705
    X(14845937-14849194) WBGene00007772
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YGR067C)4 Putative protein of unknown function; contains a zinc more   --   7(624786-622372) 852958  NP_011581.1 


    ENSEMBL Gene Tree for WT1 (if available)
    TreeFam Gene Tree for WT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WT1 gene
    EGR32  EGR12  EGR42  EGR22  
    Selected SIMAP similar genes for WT1 using alignment to 16 protein entries:     WT1_HUMAN (see all proteins) (see all similar genes):
    ZNF235    ZNF224    EGR4    ZNF653    KLF6    Sp1
    ZNF180    SP3    SP1    DKFZp686N0199    A-328A3.4    KLF13
    KLF4    KLF7    ZNF778    ZNF234    KLF16    KLF1

    Find genes that share paralogs with WT1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WT1 (see all 1198)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22345841,2,,4
    C,FWilms tumor 1 (WT1)4 --32379411(-) AGGATC/TCCATG 10 P S mis1 ese33Minor allele frequency- T:0.00NA 4554
    VAR_0150544
    Denys-Drash syndrome (DDS)4--see VAR_0150542 M R mis40--------
    VAR_0438014
    Nephrotic syndrome 4 (NPHS4)4--see VAR_0438012 F L mis40--------
    VAR_0150564
    Denys-Drash syndrome (DDS)4--see VAR_0150562 H Y mis40--------
    VAR_0077434
    Denys-Drash syndrome (DDS)4--see VAR_0077432 C Y mis40--------
    VAR_0150534
    Nephrotic syndrome 4 (NPHS4)4--see VAR_0150532 R Q mis40--------
    VAR_0438054
    Nephrotic syndrome 4 (NPHS4)4--see VAR_0438052 C R mis40--------
    VAR_0077524
    Denys-Drash syndrome (DDS)4--see VAR_0077522 D G mis40--------
    VAR_0077484
    Nephrotic syndrome 4 (NPHS4)4--see VAR_0077482 H Y mis40--------
    VAR_0077404
    Wilms tumor 1 (WT1)4--see VAR_0077402 S N mis40--------

    HapMap Linkage Disequilibrium report for WT1 (32409321 - 32457176 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for WT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv271370CNV Insertion20981092
    esv273806CNV Insertion20981092
    nsv832108CNV Loss17160897

    Human Gene Mutation Database (HGMD): WT1
    4 Site Specific Mutation Identification with PCR Assays for WT1:
    Cosmic IdAA Change
    21392p.A314fs*4
    21418p.V303fs*14
    27307p.S313*
    21397p.R390*
    4 Site Specific Cancer Mutation PCR Panels containing WT1:
    Hematopoietic Neoplasms
    Acute Myeloid Leukemia
    Cancer Comprehensive Panel 384HT
    Tumor Suppressor Panel 384HT
    Search QIAGEN SeqTarget long-range PCR primers for resequencing WT1
    DNA2.0 Custom Variant and Variant Library Synthesis for WT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607102   
    OMIM disorders: 194070  194080  256370  136680  608978  156240  
    UniProtKB/Swiss-Prot: WT1_HUMAN, P19544
  • Frasier syndrome (FS) [MIM:136680]: Characterized by a slowly progressing nephropathy leading to renal
    failure in adolescence or early adulthood, male pseudohermaphroditism, and no Wilms tumor. As for histological
    findings of the kidneys, focal glomerular sclerosis is often observed. There is phenotypic overlap with
    Denys-Drash syndrome. Inheritance is autosomal dominant. Note=The disease is caused by mutations affecting the
    gene represented in this entry
  • Wilms tumor 1 (WT1) [MIM:194070]: Embryonal malignancy of the kidney that affects approximately 1 in
    10'000 infants and young children. It occurs both in sporadic and hereditary forms. Note=The disease is caused by
    mutations affecting the gene represented in this entry
  • Denys-Drash syndrome (DDS) [MIM:194080]: Typical nephropathy characterized by diffuse mesangial
    sclerosis, genital abnormalities, and/or Wilms tumor. There is phenotypic overlap with WAGR syndrome and Frasier
    syndrome. Inheritance is autosomal dominant, but most cases are sporadic. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • Nephrotic syndrome 4 (NPHS4) [MIM:256370]: A form of nephrotic syndrome, a renal disease clinically
    characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and
    edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and
    diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress
    to end-stage renal failure. Most patients with NPHS4 show diffuse mesangial sclerosis on renal biopsy, which is a
    pathologic entity characterized by mesangial matrix expansion with no mesangial hypercellularity, hypertrophy of
    the podocytes, vacuolized podocytes, thickened basement membranes, and diminished patency of the capillary lumen.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Meacham syndrome (MEACHS) [MIM:608978]: Rare sporadically occurring multiple malformation syndrome
    characterized by male pseudohermaphroditism with abnormal internal female genitalia comprising a uterus and
    double or septate vagina, complex congenital heart defect and diaphragmatic abnormalities. Note=The disease is
    caused by mutations affecting the gene represented in this entry
  • Note=A chromosomal aberration involving WT1 may be a cause of desmoplastic small round cell tumor
    (DSRCT). Translocation t(11;22)(p13;q12) with EWSR1
  • Mesothelioma, malignant (MESOM) [MIM:156240]: An aggressive neoplasm of the serosal lining of the chest.
    It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other
    regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. Note=The
    disease may be caused by mutations affecting the gene represented in this entry

  • Selected diseases for WT1 (see all 55):    
    About MalaCards
    wt1-related disorders    denys-drash syndrome    familial wilms tumor    meacham syndrome
    nephrotic syndrome, type 4    diffuse mesangial sclerosis    wilms tumor, type 1    childhood kidney neoplasm
    wilms tumor-aniridia-genital anomalies-retardation syndrome    sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis    adenomatoid tumor    mesothelioma, somatic
    frasier syndrome    steroid-resistant nephrotic syndrome    mesoblastic nephroma    familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis
    gout susceptibility 4    wilms tumor, somatic    wagr syndrome    desmoplastic small round cell tumor

    16 diseases from the University of Copenhagen DISEASES database for WT1:
    Nephroblastoma     Denys-Drash syndrome     Frasier syndrome     WAGR syndrome
    Aniridia     Leukemia     Pseudohermaphroditism     Gonadoblastoma
    Kidney disease     Benign mesothelioma     Metanephric adenoma     Gonadal dysgenesis
    Malignant mesothelioma     Hypospadias     Carcinoma     Childhood kidney neoplasm

    Find genes that share disorders with WT1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for WT1 gene (see all 89)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wilms tumor 98.2 1174 18231640 (6), 18311776 (6), 18564415 (6), 8393432 (5) (see all 99)
    denys-drash syndrome 96.9 110 1327525 (3), 8810912 (3), 18197048 (3), 1655284 (2) (see all 81)
    frasier syndrome 95.4 55 10670748 (3), 16440249 (3), 9499425 (3), 10762296 (3) (see all 37)
    wagr syndrome 92.2 36 15779010 (2), 7687865 (2), 8396067 (2), 17533022 (2) (see all 23)
    mesangial sclerosis, diffuse 91.4 26 9529364 (2), 9916932 (2), 15682315 (1), 20150449 (1) (see all 20)
    aniridia 85.2 40 17630404 (4), 8616775 (2), 18402324 (2), 15779010 (1) (see all 31)
    pseudohermaphroditism 84.3 11 14671061 (2), 10505700 (2), 9529364 (1), 12970737 (1) (see all 8)
    minimal residual disease 82.6 89 12357365 (3), 9535047 (2), 12007019 (2), 18801058 (2) (see all 59)
    nphs1 80 23 17371932 (5), 15504938 (3), 16912710 (2), 18443213 (2) (see all 14)
    genitourinary anomaly 79.6 24 9817285 (3), 15779010 (2), 7700638 (1), 19096215 (1) (see all 19)

    GeneTests: WT1
    GeneReviews: WT1
    Genetic Association Database (GAD): WT1
    Human Genome Epidemiology (HuGE) Navigator: WT1 (45 documents)
    Tumor Gene Database (TGDB): WT1

    Export disorders for WT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WT1 gene, integrated from 10 sources (see all 1277):
    (articles sorted by number of sources associating them with WT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prevalence of WT1 mutations in a large cohort of patients with steroid-resistant and steroid-sensitive nephrotic syndrome. (PubMed id 15253707)1, 2, 4, 9 Ruf R.G.... Hildebrandt F. (Kidney Int. 2004)
    2. Mutation analysis of five candidate genes in Chinese patients with hypospadias. (PubMed id 15266301)1, 2, 4, 9 Wang Y....Shen Y. (Eur. J. Hum. Genet. 2004)
    3. Twenty-four new cases of WT1 germline mutations and review of the literature: genotype/phenotype correlations for Wilms tumor development. (PubMed id 15150775)1, 2, 4, 9 Royer-Pokora B.... Huff V. (Am. J. Med. Genet. A 2004)
    4. A novel mutation H373Y in the Wilms' tumor suppressor gene, WT1, associated with Denys-Drash syndrome. (PubMed id 8956030)1, 2, 4, 9 Ghahremani M....Pelletier J. (Hum. Hered. 1996)
    5. Germline mutations in the Wilms' tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome. (PubMed id 1655284)1, 2, 4, 9 Pelletier J.... Housman D.E. (Cell 1991)
    6. Nephrotic syndrome in the first year of life: two thirds of cases are caused by mutations in 4 genes (NPHS1, NPHS2, WT1, and LAMB2). (PubMed id 17371932)1, 4, 9 Hinkes B.G....Hildebrandt F. (Pediatrics 2007)
    7. Eye involvement in children with primary focal segmental glomerulosclerosis. (PubMed id 18058136)1, 4, 9 Ozaltin F....Bakkaloglu A. (Pediatr. Nephrol. 2008)
    8. Inhibition of Wilms tumor 1 transactivation by bone marrow zinc finger 2, a novel transcriptional repressor. (PubMed id 12239212)1, 2, 9 Lee T.H.... Pelletier J. (J. Biol. Chem. 2002)
    9. Zinc finger point mutations within the WT1 gene in Wilms tumor patients. (PubMed id 1317572)1, 2, 9 Little M.H....Hastie N.D. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    10. Clinical relevance of mutations in the Wilms tumor suppressor 1 gene WT1 and the cadherin-associated protein beta1 gene CTNNB1 for patients with Wilms tumors: results of long-term surveillance of 71 patients from International Society of Pediatric Oncology Study 9/Society for Pediatric Oncology. (PubMed id 18618575)1, 4, 9 Royer-Pokora B....von Harrach M. (Cancer 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7490 HGNC: 12796 AceView: WIT-1 Ensembl:ENSG00000184937 euGenes: HUgn7490
    ECgene: WT1 Kegg: 7490 H-InvDB: WT1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WT1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WT1 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=WT1[genesymbol]
    NIEHS-SNPshttp://egp.gs.washington.edu/data/wt1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WT1 gene:
    Search GeneIP for patents involving WT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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