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Aliases for WSCD2 Gene

Aliases for WSCD2 Gene

  • WSC Domain Containing 2 2 3
  • KIAA0789 4

External Ids for WSCD2 Gene

Previous GeneCards Identifiers for WSCD2 Gene

  • GC12P107047
  • GC12P108523
  • GC12P105587

Summaries for WSCD2 Gene

GeneCards Summary for WSCD2 Gene

WSCD2 (WSC Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is WSCD1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WSCD2 Gene

Genomics for WSCD2 Gene

Regulatory Elements for WSCD2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WSCD2 Gene

Start:
108,129,471 bp from pter
End:
108,250,537 bp from pter
Size:
121,067 bases
Orientation:
Plus strand

Genomic View for WSCD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WSCD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WSCD2 Gene

Proteins for WSCD2 Gene

  • Protein details for WSCD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2TBF2-WSCD2_HUMAN
    Recommended name:
    WSC domain-containing protein 2
    Protein Accession:
    Q2TBF2
    Secondary Accessions:
    • B2RN48
    • B4DES1
    • Q8IY35
    • Q9Y4B7

    Protein attributes for WSCD2 Gene

    Size:
    565 amino acids
    Molecular mass:
    63817 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH37969.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. The N-terminus may be contaminated with vector sequence.; Evidence={ECO:0000305}; Sequence=BAA34509.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for WSCD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WSCD2 Gene

Proteomics data for WSCD2 Gene at MOPED

Post-translational modifications for WSCD2 Gene

  • Glycosylation at Asn189 and Asn242
  • Modification sites at PhosphoSitePlus

Other Protein References for WSCD2 Gene

No data available for DME Specific Peptides for WSCD2 Gene

Domains for WSCD2 Gene

Protein Domains for WSCD2 Gene

Suggested Antigen Peptide Sequences for WSCD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2TBF2

UniProtKB/Swiss-Prot:

WSCD2_HUMAN :
  • Q2TBF2
Domain:
  • Contains 2 WSC domains.
Family:
  • Belongs to the WSCD family.
genes like me logo Genes that share domains with WSCD2: view

No data available for Gene Families for WSCD2 Gene

Function for WSCD2 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WSCD2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for WSCD2 Gene

Localization for WSCD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WSCD2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WSCD2 Gene COMPARTMENTS Subcellular localization image for WSCD2 gene
Compartment Confidence
extracellular 2
golgi apparatus 2
cytosol 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for WSCD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with WSCD2: view

Pathways for WSCD2 Gene

SuperPathways for WSCD2 Gene

No Data Available

Interacting Proteins for WSCD2 Gene

Gene Ontology (GO) - Biological Process for WSCD2 Gene

None

No data available for Pathways by source for WSCD2 Gene

Transcripts for WSCD2 Gene

Unigene Clusters for WSCD2 Gene

WSC domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WSCD2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for WSCD2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WSCD2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^
SP1: - - -
SP2: - - - - - - -
SP3: -
SP4: - - - - - - - - - - - - -
SP5: -
SP6: - - - - -
SP7: - - - - -
SP8: - - - - -
SP9: - -
SP10:
SP11: - - -

ExUns: 13 ^ 14a · 14b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for WSCD2 Gene

GeneLoc Exon Structure for
WSCD2
ECgene alternative splicing isoforms for
WSCD2

Expression for WSCD2 Gene

mRNA expression in normal human tissues for WSCD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WSCD2 Gene

This gene is overexpressed in Brain - Cerebellum (12.3) and Brain - Cerebellar Hemisphere (11.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for WSCD2 Gene

SOURCE GeneReport for Unigene cluster for WSCD2 Gene Hs.143591

genes like me logo Genes that share expressions with WSCD2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for WSCD2 Gene

Orthologs for WSCD2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WSCD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WSCD2 35
  • 99.47 (n)
  • 99.82 (a)
WSCD2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WSCD2 35
  • 90.37 (n)
  • 96.1 (a)
WSCD2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WSCD2 35
  • 89.83 (n)
  • 95.74 (a)
WSCD2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wscd2 35
  • 86.41 (n)
  • 91.84 (a)
Wscd2 16
Wscd2 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WSCD2 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WSCD2 36
  • 40 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wscd2 35
  • 85.66 (n)
  • 91.86 (a)
chicken
(Gallus gallus)
Aves WSCD2 35
  • 77.5 (n)
  • 80.79 (a)
WSCD2 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WSCD2 36
  • 79 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3145 35
zebrafish
(Danio rerio)
Actinopterygii wscd2 35
  • 68.45 (n)
  • 72.95 (a)
wscd2 36
  • 71 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9164 36
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes WSC3 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToMany
Species with no ortholog for WSCD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WSCD2 Gene

ENSEMBL:
Gene Tree for WSCD2 (if available)
TreeFam:
Gene Tree for WSCD2 (if available)

Paralogs for WSCD2 Gene

Paralogs for WSCD2 Gene

Selected SIMAP similar genes for WSCD2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with WSCD2: view

Variants for WSCD2 Gene

Sequence variations from dbSNP and Humsavar for WSCD2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs193132 -- 108,132,412(-) TAAGT(G/T)ATGCT intron-variant
rs338163 -- 108,133,784(-) CAAGA(C/T)AGATT intron-variant
rs338164 -- 108,132,559(-) CACAA(A/G)TGCAC intron-variant
rs338165 -- 108,132,529(-) CACAC(A/G)CACAC intron-variant
rs338166 -- 108,138,732(-) AAAGA(A/G)AAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WSCD2 Gene

Variant ID Type Subtype PubMed ID
nsv832512 CNV Gain 17160897
esv2676544 CNV Deletion 23128226
esv8762 CNV Loss 19470904
esv2665617 CNV Deletion 23128226

Relevant External Links for WSCD2 Gene

HapMap Linkage Disequilibrium report
WSCD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WSCD2 Gene

Disorders for WSCD2 Gene

(1) University of Copenhagen DISEASES for WSCD2 Gene

Relevant External Links for WSCD2

Genetic Association Database (GAD)
WSCD2
Human Genome Epidemiology (HuGE) Navigator
WSCD2
genes like me logo Genes that share disorders with WSCD2: view

No data available for UniProtKB/Swiss-Prot for WSCD2 Gene

Publications for WSCD2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. High-density association study and nomination of susceptibility genes for hypertension in the Japanese National Project. (PMID: 18003638) Kato N. … Tomoike H. (Hum. Mol. Genet. 2008) 3 48
  3. Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci. (PMID: 22365631) Greenwood T.A. … Kelsoe J.R. (Biol. Psychiatry 2012) 3 48
  4. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for WSCD2 Gene

Sources for WSCD2 Gene

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