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Aliases for WSCD2 Gene

Aliases for WSCD2 Gene

  • WSC Domain Containing 2 2 3 5
  • KIAA0789 4

External Ids for WSCD2 Gene

Previous GeneCards Identifiers for WSCD2 Gene

  • GC12P107047
  • GC12P108523
  • GC12P105587

Summaries for WSCD2 Gene

GeneCards Summary for WSCD2 Gene

WSCD2 (WSC Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is WSCD1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WSCD2 Gene

Genomics for WSCD2 Gene

Regulatory Elements for WSCD2 Gene

Enhancers for WSCD2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WSCD2 on UCSC Golden Path with GeneCards custom track

Promoters for WSCD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WSCD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for WSCD2 Gene

108,129,343 bp from pter
108,250,537 bp from pter
121,195 bases
Plus strand

Genomic View for WSCD2 Gene

Genes around WSCD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WSCD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WSCD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WSCD2 Gene

Proteins for WSCD2 Gene

  • Protein details for WSCD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WSC domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • B2RN48
    • B4DES1
    • Q8IY35
    • Q9Y4B7

    Protein attributes for WSCD2 Gene

    565 amino acids
    Molecular mass:
    63817 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH37969.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. The N-terminus may be contaminated with vector sequence.; Evidence={ECO:0000305}; Sequence=BAA34509.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for WSCD2 Gene


neXtProt entry for WSCD2 Gene

Proteomics data for WSCD2 Gene at MOPED

Post-translational modifications for WSCD2 Gene

  • Glycosylation at Asn 189 and Asn 242
  • Modification sites at PhosphoSitePlus

Other Protein References for WSCD2 Gene

No data available for DME Specific Peptides for WSCD2 Gene

Domains & Families for WSCD2 Gene

Protein Domains for WSCD2 Gene

Suggested Antigen Peptide Sequences for WSCD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 WSC domains.
  • Belongs to the WSCD family.
  • Contains 2 WSC domains.
  • Belongs to the WSCD family.
genes like me logo Genes that share domains with WSCD2: view

No data available for Gene Families for WSCD2 Gene

Function for WSCD2 Gene

Phenotypes for WSCD2 Gene

genes like me logo Genes that share phenotypes with WSCD2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WSCD2 Gene

Localization for WSCD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WSCD2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for WSCD2 Gene COMPARTMENTS Subcellular localization image for WSCD2 gene
Compartment Confidence
extracellular 2
golgi apparatus 2
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for WSCD2 Gene

Pathways & Interactions for WSCD2 Gene

SuperPathways for WSCD2 Gene

No Data Available

Interacting Proteins for WSCD2 Gene

Gene Ontology (GO) - Biological Process for WSCD2 Gene


No data available for Pathways by source and SIGNOR curated interactions for WSCD2 Gene

Drugs & Compounds for WSCD2 Gene

No Compound Related Data Available

Transcripts for WSCD2 Gene

Unigene Clusters for WSCD2 Gene

WSC domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WSCD2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^
SP1: - - -
SP2: - - - - - - -
SP3: -
SP4: - - - - - - - - - - - - -
SP5: -
SP6: - - - - -
SP7: - - - - -
SP8: - - - - -
SP9: - -
SP11: - - -

ExUns: 13 ^ 14a · 14b
SP1: -
SP2: -

Relevant External Links for WSCD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WSCD2 Gene

mRNA expression in normal human tissues for WSCD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WSCD2 Gene

This gene is overexpressed in Brain - Cerebellum (x12.3) and Brain - Cerebellar Hemisphere (x11.0).

Protein differential expression in normal tissues from HIPED for WSCD2 Gene

This gene is overexpressed in Pancreatic juice (55.2) and Spleen (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WSCD2 Gene

SOURCE GeneReport for Unigene cluster for WSCD2 Gene Hs.143591

genes like me logo Genes that share expression patterns with WSCD2: view

Protein tissue co-expression partners for WSCD2 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for WSCD2 Gene

Orthologs for WSCD2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WSCD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WSCD2 35
  • 90.37 (n)
  • 96.1 (a)
WSCD2 36
  • 96 (a)
(Canis familiaris)
Mammalia WSCD2 35
  • 89.83 (n)
  • 95.74 (a)
WSCD2 36
  • 96 (a)
(Mus musculus)
Mammalia Wscd2 35
  • 86.41 (n)
  • 91.84 (a)
Wscd2 16
Wscd2 36
  • 91 (a)
(Pan troglodytes)
Mammalia WSCD2 35
  • 99.47 (n)
  • 99.82 (a)
WSCD2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Wscd2 35
  • 85.66 (n)
  • 91.86 (a)
(Monodelphis domestica)
Mammalia WSCD2 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia WSCD2 36
  • 40 (a)
(Gallus gallus)
Aves WSCD2 35
  • 77.5 (n)
  • 80.79 (a)
WSCD2 36
  • 79 (a)
(Anolis carolinensis)
Reptilia WSCD2 36
  • 79 (a)
(Danio rerio)
Actinopterygii wscd2 35
  • 68.45 (n)
  • 72.95 (a)
wscd2 36
  • 71 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3145 35
fruit fly
(Drosophila melanogaster)
Insecta CG9164 36
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes WSC3 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
Species with no ortholog for WSCD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WSCD2 Gene

Gene Tree for WSCD2 (if available)
Gene Tree for WSCD2 (if available)

Paralogs for WSCD2 Gene

Paralogs for WSCD2 Gene

(1) SIMAP similar genes for WSCD2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with WSCD2: view

Variants for WSCD2 Gene

Sequence variations from dbSNP and Humsavar for WSCD2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_035161 -
rs1981936 -- 108,148,814(-) GTCAG(G/T)GGCTT intron-variant
rs1991298 -- 108,132,296(-) GTTTT(C/T)TCAGA intron-variant
rs193132 -- 108,132,412(-) TAAGT(G/T)ATGCT intron-variant
rs7138154 -- 108,152,014(+) GCGTC(A/G)CTGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WSCD2 Gene

Variant ID Type Subtype PubMed ID
nsv832512 CNV Gain 17160897
esv2676544 CNV Deletion 23128226
esv8762 CNV Loss 19470904
esv2665617 CNV Deletion 23128226

Variation tolerance for WSCD2 Gene

Residual Variation Intolerance Score: 38.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.59; 91.27% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for WSCD2 Gene

Disorders for WSCD2 Gene

Relevant External Links for WSCD2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for WSCD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WSCD2 Gene

Publications for WSCD2 Gene

  1. Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci. (PMID: 22365631) Greenwood T.A. … Kelsoe J.R. (Biol. Psychiatry 2012) 3 48 67
  2. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3
  3. High-density association study and nomination of susceptibility genes for hypertension in the Japanese National Project. (PMID: 18003638) Kato N. … Tomoike H. (Hum. Mol. Genet. 2008) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for WSCD2 Gene

Sources for WSCD2 Gene