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Aliases for WSCD2 Gene

Aliases for WSCD2 Gene

  • WSC Domain Containing 2 2 3 5
  • KIAA0789 4

External Ids for WSCD2 Gene

Previous GeneCards Identifiers for WSCD2 Gene

  • GC12P107047
  • GC12P108523
  • GC12P105587

Summaries for WSCD2 Gene

GeneCards Summary for WSCD2 Gene

WSCD2 (WSC Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is WSCD1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WSCD2 Gene

Genomics for WSCD2 Gene

Regulatory Elements for WSCD2 Gene

Enhancers for WSCD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G108699 2 FANTOM5 Ensembl ENCODE dbSUPER 15.1 +572.4 572400 4.6 CREB3L1 MLX ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 SART3 CORO1C WSCD2 RNU7-169P UBE3B RNU4-32P LOC101929162 PRDM4 ENSG00000257221 MVK
GH12G109096 1.3 ENCODE dbSUPER 15.1 +969.3 969345 3.4 PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 FOS WSCD2 ACACB UBE3B SART3 MYO1H UNG GC12M109089
GH12G108664 1.2 dbSUPER 15.1 +529.4 529360 0.9 MLX ZFP64 DMAP1 YY1 ZNF143 ZNF416 ZNF263 SP3 TBX21 SSRP1 SART3 PRDM4 PWP1 UBE3B WSCD2 RNU4-32P LOC101929162 ENSG00000257221 RNU7-169P GC12P108645
GH12G108661 1.2 dbSUPER 15.1 +530.8 530834 3.6 MLX ZFP64 DMAP1 YY1 ZNF143 ZNF416 ZNF263 SP3 TBX21 SSRP1 SART3 PRDM4 PWP1 UBE3B WSCD2 RNU4-32P LOC101929162 ENSG00000257221 CORO1C RNU7-169P
GH12G109051 1.2 ENCODE 15.1 +924.2 924151 3.1 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 SP3 NFYC TBX21 SART3 UBE3B WSCD2 USP30 USP30-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WSCD2 on UCSC Golden Path with GeneCards custom track

Promoters for WSCD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000057010 157 601 HDGF HDAC1 CBX3 PTBP1 RB1 ZBTB40 RAD21 GLIS2 CBX5 ELK1

Genomic Location for WSCD2 Gene

Chromosome:
12
Start:
108,129,343 bp from pter
End:
108,250,537 bp from pter
Size:
121,195 bases
Orientation:
Plus strand

Genomic View for WSCD2 Gene

Genes around WSCD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WSCD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WSCD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WSCD2 Gene

Proteins for WSCD2 Gene

  • Protein details for WSCD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2TBF2-WSCD2_HUMAN
    Recommended name:
    WSC domain-containing protein 2
    Protein Accession:
    Q2TBF2
    Secondary Accessions:
    • B2RN48
    • B4DES1
    • Q8IY35
    • Q9Y4B7

    Protein attributes for WSCD2 Gene

    Size:
    565 amino acids
    Molecular mass:
    63817 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH37969.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence. The N-terminus may be contaminated with vector sequence.; Evidence={ECO:0000305}; Sequence=BAA34509.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for WSCD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WSCD2 Gene

Post-translational modifications for WSCD2 Gene

  • Glycosylation at isoforms=2189 and posLast=242242
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WSCD2 Gene

Domains & Families for WSCD2 Gene

Protein Domains for WSCD2 Gene

Suggested Antigen Peptide Sequences for WSCD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2TBF2

UniProtKB/Swiss-Prot:

WSCD2_HUMAN :
  • Belongs to the WSCD family.
Family:
  • Belongs to the WSCD family.
genes like me logo Genes that share domains with WSCD2: view

No data available for Gene Families for WSCD2 Gene

Function for WSCD2 Gene

Phenotypes for WSCD2 Gene

genes like me logo Genes that share phenotypes with WSCD2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WSCD2 Gene

Localization for WSCD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WSCD2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WSCD2 gene
Compartment Confidence
extracellular 2
golgi apparatus 2
mitochondrion 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for WSCD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with WSCD2: view

Pathways & Interactions for WSCD2 Gene

SuperPathways for WSCD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WSCD2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WSCD2 Gene

Transcripts for WSCD2 Gene

Unigene Clusters for WSCD2 Gene

WSC domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WSCD2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^
SP1: - - -
SP2: - - - - - - -
SP3: -
SP4: - - - - - - - - - - - - -
SP5: -
SP6: - - - - -
SP7: - - - - -
SP8: - - - - -
SP9: - -
SP10:
SP11: - - -

ExUns: 13 ^ 14a · 14b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for WSCD2 Gene

GeneLoc Exon Structure for
WSCD2
ECgene alternative splicing isoforms for
WSCD2

Expression for WSCD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WSCD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WSCD2 Gene

This gene is overexpressed in Brain - Cerebellum (x12.3) and Brain - Cerebellar Hemisphere (x11.0).

Protein differential expression in normal tissues from HIPED for WSCD2 Gene

This gene is overexpressed in Pancreatic juice (55.2) and Spleen (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WSCD2 Gene



Protein tissue co-expression partners for WSCD2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WSCD2 Gene:

WSCD2

SOURCE GeneReport for Unigene cluster for WSCD2 Gene:

Hs.143591

Evidence on tissue expression from TISSUES for WSCD2 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with WSCD2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WSCD2 Gene

Orthologs for WSCD2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WSCD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WSCD2 34 35
  • 99.47 (n)
cow
(Bos Taurus)
Mammalia WSCD2 34 35
  • 90.37 (n)
dog
(Canis familiaris)
Mammalia WSCD2 34 35
  • 89.83 (n)
mouse
(Mus musculus)
Mammalia Wscd2 34 16 35
  • 86.41 (n)
rat
(Rattus norvegicus)
Mammalia Wscd2 34
  • 85.66 (n)
oppossum
(Monodelphis domestica)
Mammalia WSCD2 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WSCD2 35
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves WSCD2 34 35
  • 77.5 (n)
lizard
(Anolis carolinensis)
Reptilia WSCD2 35
  • 79 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii wscd2 34 35
  • 68.45 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3145 34
fruit fly
(Drosophila melanogaster)
Insecta CG9164 35
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes WSC3 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 27 (a)
OneToMany
Species where no ortholog for WSCD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WSCD2 Gene

ENSEMBL:
Gene Tree for WSCD2 (if available)
TreeFam:
Gene Tree for WSCD2 (if available)

Paralogs for WSCD2 Gene

Paralogs for WSCD2 Gene

(1) SIMAP similar genes for WSCD2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with WSCD2: view

Variants for WSCD2 Gene

Sequence variations from dbSNP and Humsavar for WSCD2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000001833 -- 108,205,359(+) AGACA(A/G)TGTAT intron-variant
rs1000008605 -- 108,247,481(+) TTCCA(C/G)GGAGA intron-variant
rs1000012321 -- 108,132,680(+) GTGTG(C/T)TCTAG intron-variant
rs1000080930 -- 108,176,968(+) TTAAA(C/G)CACAG intron-variant, nc-transcript-variant
rs1000098806 -- 108,211,674(+) TTTGA(A/G)ACAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WSCD2 Gene

Variant ID Type Subtype PubMed ID
esv2665617 CNV deletion 23128226
esv2676544 CNV deletion 23128226
esv3386246 CNV duplication 20981092
esv3630703 CNV loss 21293372
esv8762 CNV loss 19470904
nsv1041167 CNV gain 25217958
nsv832512 CNV gain 17160897

Variation tolerance for WSCD2 Gene

Residual Variation Intolerance Score: 38.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.59; 91.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WSCD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WSCD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WSCD2 Gene

Disorders for WSCD2 Gene

Relevant External Links for WSCD2

Genetic Association Database (GAD)
WSCD2
Human Genome Epidemiology (HuGE) Navigator
WSCD2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WSCD2

No disorders were found for WSCD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WSCD2 Gene

Publications for WSCD2 Gene

  1. Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci. (PMID: 22365631) Greenwood T.A. … Kelsoe J.R. (Biol. Psychiatry 2012) 3 46 64
  2. High-density association study and nomination of susceptibility genes for hypertension in the Japanese National Project. (PMID: 18003638) Kato N. … Tomoike H. (Hum. Mol. Genet. 2008) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 3 4 64
  5. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3 64

Products for WSCD2 Gene

Sources for WSCD2 Gene

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