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Aliases for WSCD1 Gene

Aliases for WSCD1 Gene

  • WSC Domain Containing 1 2 3 5
  • KIAA0523 4

External Ids for WSCD1 Gene

Previous GeneCards Identifiers for WSCD1 Gene

  • GC17P005915
  • GC17P005676

Summaries for WSCD1 Gene

GeneCards Summary for WSCD1 Gene

WSCD1 (WSC Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include sulfotransferase activity. An important paralog of this gene is WSCD2.

Additional gene information for WSCD1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WSCD1 Gene

Genomics for WSCD1 Gene

Regulatory Elements for WSCD1 Gene

Enhancers for WSCD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H005831 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9 +62.7 62708 5 PKNOX1 FOXA2 NFIB SAP130 JUN SIN3A ZNF384 TEAD3 CTBP1 GATA3 WSCD1 USP6 GC17M005827 PIR60431
GH17H006110 0.7 ENCODE 11 +338.5 338522 0 SAP130 JUN NR2F1 MAX JUNB DPF2 BATF ZNF217 BCL11A EED WSCD1 PIR32157 GC17M006087
GH17H006020 0.4 ENCODE 17.7 +248.5 248507 1 EGR1 WSCD1 GC17M005970 GC17M006087
GH17H006096 1.1 Ensembl ENCODE dbSUPER 5.8 +326.1 326129 3 NFIC STAT1 POLR2A TAL1 JUN ZIC2 NR2F2 WSCD1 PITPNM3 GC17M006087 PIR32157
GH17H006238 0.6 Ensembl ENCODE 9.9 +466.2 466202 0 POLR2A WSCD1 GC17M006229 RNU6-1264P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WSCD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for WSCD1 Gene

Chromosome:
17
Start:
5,772,234 bp from pter
End:
6,124,427 bp from pter
Size:
352,194 bases
Orientation:
Plus strand

Genomic View for WSCD1 Gene

Genes around WSCD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WSCD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WSCD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WSCD1 Gene

Proteins for WSCD1 Gene

  • Protein details for WSCD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q658N2-WSCD1_HUMAN
    Recommended name:
    WSC domain-containing protein 1
    Protein Accession:
    Q658N2
    Secondary Accessions:
    • A8K0N8
    • D3DTM3
    • O60276
    • Q96G45

    Protein attributes for WSCD1 Gene

    Size:
    575 amino acids
    Molecular mass:
    65694 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WSCD1 Gene

Post-translational modifications for WSCD1 Gene

  • Glycosylation at Asn257 and Asn348
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WSCD1 Gene

Domains & Families for WSCD1 Gene

Gene Families for WSCD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for WSCD1 Gene

Suggested Antigen Peptide Sequences for WSCD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q658N2

UniProtKB/Swiss-Prot:

WSCD1_HUMAN :
  • Belongs to the WSCD family.
Family:
  • Belongs to the WSCD family.
genes like me logo Genes that share domains with WSCD1: view

Function for WSCD1 Gene

Phenotypes From GWAS Catalog for WSCD1 Gene

Gene Ontology (GO) - Molecular Function for WSCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity IEA --
genes like me logo Genes that share ontologies with WSCD1: view
genes like me logo Genes that share phenotypes with WSCD1: view

Animal Models for WSCD1 Gene

MGI Knock Outs for WSCD1:

Animal Model Products

  • Taconic Biosciences Mouse Models for WSCD1

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for WSCD1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WSCD1 Gene

Localization for WSCD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WSCD1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WSCD1 gene
Compartment Confidence
extracellular 2
golgi apparatus 2
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WSCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with WSCD1: view

Pathways & Interactions for WSCD1 Gene

SuperPathways for WSCD1 Gene

No Data Available

Interacting Proteins for WSCD1 Gene

Gene Ontology (GO) - Biological Process for WSCD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WSCD1 Gene

Drugs & Compounds for WSCD1 Gene

No Compound Related Data Available

Transcripts for WSCD1 Gene

Unigene Clusters for WSCD1 Gene

WSC domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for WSCD1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for WSCD1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2: -
SP3: -
SP4:
SP5: - -

Relevant External Links for WSCD1 Gene

GeneLoc Exon Structure for
WSCD1
ECgene alternative splicing isoforms for
WSCD1

Expression for WSCD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WSCD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WSCD1 Gene

This gene is overexpressed in Brain - Cerebellum (x4.3) and Brain - Cerebellar Hemisphere (x4.2).

Protein differential expression in normal tissues from HIPED for WSCD1 Gene

This gene is overexpressed in Synovial fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WSCD1 Gene



Protein tissue co-expression partners for WSCD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of WSCD1 Gene:

WSCD1

SOURCE GeneReport for Unigene cluster for WSCD1 Gene:

Hs.370166

Evidence on tissue expression from TISSUES for WSCD1 Gene

  • Nervous system(4.7)
  • Muscle(4.1)
  • Stomach(4.1)
genes like me logo Genes that share expression patterns with WSCD1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WSCD1 Gene

Orthologs for WSCD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WSCD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WSCD1 33 34
  • 98.33 (n)
cow
(Bos Taurus)
Mammalia WSCD1 33 34
  • 88.93 (n)
dog
(Canis familiaris)
Mammalia WSCD1 33 34
  • 85.68 (n)
rat
(Rattus norvegicus)
Mammalia Wscd1 33
  • 82.98 (n)
mouse
(Mus musculus)
Mammalia Wscd1 33 16 34
  • 82.4 (n)
oppossum
(Monodelphis domestica)
Mammalia WSCD1 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WSCD1 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves WSCD1 33 34
  • 70.41 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 68 (a)
OneToMany
-- 34
  • 62 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia wscd1 33
  • 62.56 (n)
zebrafish
(Danio rerio)
Actinopterygii CABZ01007222.1 34
  • 65 (a)
OneToMany
si:ch211-55a7.1 33
  • 55.83 (n)
WSCD1 (2 of 3) 34
  • 49 (a)
OneToMany
WSCD1 (1 of 3) 34
  • 38 (a)
OneToMany
Dr.12914 33
fruit fly
(Drosophila melanogaster)
Insecta CG9164 34
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLG1 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 26 (a)
OneToMany
Species where no ortholog for WSCD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WSCD1 Gene

ENSEMBL:
Gene Tree for WSCD1 (if available)
TreeFam:
Gene Tree for WSCD1 (if available)

Paralogs for WSCD1 Gene

Paralogs for WSCD1 Gene

(1) SIMAP similar genes for WSCD1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with WSCD1: view

Variants for WSCD1 Gene

Sequence variations from dbSNP and Humsavar for WSCD1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000020614 -- 6,092,753(+) ATTCT(A/G)AAAGG intron-variant
rs1000032252 -- 6,086,542(+) AGAGA(C/T)GGGGT intron-variant
rs1000168980 -- 6,114,005(+) AAGGG(A/C)AAGGA intron-variant
rs1000175510 -- 6,107,976(+) AGGTG(C/T)CTCCT intron-variant
rs1000251644 -- 6,087,862(+) GCCTG(C/T)AGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WSCD1 Gene

Variant ID Type Subtype PubMed ID
esv26217 CNV loss 19812545
nsv1959 CNV deletion 18451855
nsv574278 CNV gain 21841781
nsv574310 CNV gain 21841781
nsv574311 CNV loss 21841781

Variation tolerance for WSCD1 Gene

Residual Variation Intolerance Score: 46.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.52; 64.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WSCD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WSCD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WSCD1 Gene

Disorders for WSCD1 Gene

Relevant External Links for WSCD1

Genetic Association Database (GAD)
WSCD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WSCD1

No disorders were found for WSCD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WSCD1 Gene

Publications for WSCD1 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 60
  2. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. (PMID: 25231870) Perry JR … Ong KK (Nature 2014) 3 60
  3. Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis. (PMID: 23740775) Xie G … Siminovitch KA (Arthritis and rheumatism 2013) 3 60
  4. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PMID: 19460752) Yeung ML … Jeang KT (The Journal of biological chemistry 2009) 3 60
  5. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PMID: 17903297) Seshadri S … Wolf PA (BMC medical genetics 2007) 45 60

Products for WSCD1 Gene

Sources for WSCD1 Gene

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