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Aliases for WSCD1 Gene

Aliases for WSCD1 Gene

  • WSC Domain Containing 1 2 3 5
  • KIAA0523 4

External Ids for WSCD1 Gene

Previous GeneCards Identifiers for WSCD1 Gene

  • GC17P005915
  • GC17P005676

Summaries for WSCD1 Gene

GeneCards Summary for WSCD1 Gene

WSCD1 (WSC Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include sulfotransferase activity. An important paralog of this gene is WSCD2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WSCD1 Gene

Genomics for WSCD1 Gene

Regulatory Elements for WSCD1 Gene

Enhancers for WSCD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WSCD1 on UCSC Golden Path with GeneCards custom track

Promoters for WSCD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WSCD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for WSCD1 Gene

5,772,234 bp from pter
6,124,427 bp from pter
352,194 bases
Plus strand

Genomic View for WSCD1 Gene

Genes around WSCD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WSCD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WSCD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WSCD1 Gene

Proteins for WSCD1 Gene

  • Protein details for WSCD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WSC domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • A8K0N8
    • D3DTM3
    • O60276
    • Q96G45

    Protein attributes for WSCD1 Gene

    575 amino acids
    Molecular mass:
    65694 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WSCD1 Gene

Proteomics data for WSCD1 Gene at MOPED

Post-translational modifications for WSCD1 Gene

  • Glycosylation at Asn 257 and Asn 348
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WSCD1 Gene

Domains & Families for WSCD1 Gene

Protein Domains for WSCD1 Gene

Suggested Antigen Peptide Sequences for WSCD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 WSC domains.
  • Belongs to the WSCD family.
  • Contains 2 WSC domains.
  • Belongs to the WSCD family.
genes like me logo Genes that share domains with WSCD1: view

No data available for Gene Families for WSCD1 Gene

Function for WSCD1 Gene

genes like me logo Genes that share phenotypes with WSCD1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for WSCD1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WSCD1 Gene

Localization for WSCD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WSCD1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for WSCD1 Gene COMPARTMENTS Subcellular localization image for WSCD1 gene
Compartment Confidence
extracellular 2
golgi apparatus 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for WSCD1 Gene

Pathways & Interactions for WSCD1 Gene

SuperPathways for WSCD1 Gene

No Data Available

Interacting Proteins for WSCD1 Gene

Gene Ontology (GO) - Biological Process for WSCD1 Gene


No data available for Pathways by source and SIGNOR curated interactions for WSCD1 Gene

Drugs & Compounds for WSCD1 Gene

No Compound Related Data Available

Transcripts for WSCD1 Gene

Unigene Clusters for WSCD1 Gene

WSC domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WSCD1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP2: -
SP3: -
SP5: - -

Relevant External Links for WSCD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WSCD1 Gene

mRNA expression in normal human tissues for WSCD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WSCD1 Gene

This gene is overexpressed in Brain - Cerebellum (x4.3) and Brain - Cerebellar Hemisphere (x4.2).

Protein differential expression in normal tissues from HIPED for WSCD1 Gene

This gene is overexpressed in Synovial fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WSCD1 Gene

SOURCE GeneReport for Unigene cluster for WSCD1 Gene Hs.370166

genes like me logo Genes that share expression patterns with WSCD1: view

Protein tissue co-expression partners for WSCD1 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for WSCD1 Gene

Orthologs for WSCD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WSCD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WSCD1 35
  • 88.93 (n)
  • 92.87 (a)
WSCD1 36
  • 93 (a)
(Canis familiaris)
Mammalia WSCD1 35
  • 85.68 (n)
  • 89.22 (a)
WSCD1 36
  • 89 (a)
(Mus musculus)
Mammalia Wscd1 35
  • 82.4 (n)
  • 85.84 (a)
Wscd1 16
Wscd1 36
  • 86 (a)
(Pan troglodytes)
Mammalia WSCD1 35
  • 98.33 (n)
  • 97.4 (a)
WSCD1 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Wscd1 35
  • 82.98 (n)
  • 85.66 (a)
(Monodelphis domestica)
Mammalia WSCD1 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia WSCD1 36
  • 69 (a)
(Gallus gallus)
Aves WSCD1 35
  • 70.41 (n)
  • 71.4 (a)
WSCD1 36
  • 70 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 62 (a)
-- 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wscd1 35
  • 62.56 (n)
  • 65.54 (a)
(Danio rerio)
Actinopterygii Dr.12914 35
si:ch211-55a7.1 35
  • 55.83 (n)
  • 50.89 (a)
CABZ01007222.1 36
  • 65 (a)
WSCD1 (1 of 3) 36
  • 38 (a)
WSCD1 (2 of 3) 36
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9164 36
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLG1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
Species with no ortholog for WSCD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WSCD1 Gene

Gene Tree for WSCD1 (if available)
Gene Tree for WSCD1 (if available)

Paralogs for WSCD1 Gene

Paralogs for WSCD1 Gene

(1) SIMAP similar genes for WSCD1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with WSCD1: view

Variants for WSCD1 Gene

Sequence variations from dbSNP and Humsavar for WSCD1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs17855415 - 6,090,412(+) GTAAC(C/T)ATGAG reference, missense
rs1811167 -- 6,071,980(-) CCACC(A/G)CCAAG intron-variant
rs2106231 -- 6,067,889(-) TCCTT(C/G)TCCCT upstream-variant-2KB
rs2157775 -- 6,067,688(-) TGTTT(C/G)GCTCT upstream-variant-2KB
rs916622 -- 6,071,286(-) ACGTA(C/T)GCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WSCD1 Gene

Variant ID Type Subtype PubMed ID
esv26217 CNV Loss 19812545
nsv1959 CNV Loss 18451855

Variation tolerance for WSCD1 Gene

Residual Variation Intolerance Score: 46.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.52; 64.69% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for WSCD1 Gene

Disorders for WSCD1 Gene

Relevant External Links for WSCD1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for WSCD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WSCD1 Gene

Publications for WSCD1 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 3 4 67
  2. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. (PMID: 25231870) Perry J.R. … Ong K.K. (Nature 2014) 3
  3. Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis. (PMID: 23740775) Xie G. … Siminovitch K.A. (Arthritis Rheum. 2013) 3
  4. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PMID: 19460752) Yeung M.L. … Jeang K.T. (J. Biol. Chem. 2009) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for WSCD1 Gene

Sources for WSCD1 Gene