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WSB2 Gene

protein-coding   GIFtS: 51
GCID: GC12M118470

WD Repeat And SOCS Box Containing 2

(Previous name: WD repeat and SOCS box-containing 2)
  Search for WSB2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
WD Repeat And SOCS Box Containing 21 2     SBA22
WD Repeat And SOCS Box-Containing 21 2     WD Repeat And SOCS Box Containing Protein 22
WSB-22 3     WD Repeat And SOCS Box-Containing Protein 22
CS Box-Containing WD Protein2 3     

External Ids:    HGNC: 192221   Entrez Gene: 558842   Ensembl: ENSG000001768717   UniProtKB: Q9NYS73   
ORGUL members:         

Export aliases for WSB2 gene to outside databases

Previous GC identifers: GC12M117997 GC12M118253 GC12M116882 GC12M116933 GC12M115480


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WSB2 Gene:
This gene encodes a member of the WD-protein subfamily. The encoded protein contains five WD-repeats spanning most
of the protein and an SOCS box in the C-terminus. The SOCS box may act as a bridge between specific
substrate-binding domains and E3 ubiquitin protein ligases. Three transcript variants encoding different isoforms
have been found for this gene. (provided by RefSeq, Jun 2013)

GeneCards Summary for WSB2 Gene:
WSB2 (WD repeat and SOCS box containing 2) is a protein-coding gene. An important paralog of this gene is TAF5.

UniProtKB/Swiss-Prot: WSB2_HUMAN, Q9NYS7
Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3
ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target
proteins (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the WSB2 gene promoter:
         STAT5B   STAT1   STAT4   STAT1beta   STAT5A   STAT1alpha   PPAR-gamma1   STAT2   STAT3   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWSB2 promoter sequence
   Search Chromatin IP Primers for WSB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WSB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.23   Ensembl cytogenetic band:  12q24.23   HGNC cytogenetic band: 12q24.23

WSB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WSB2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M118470:  view genomic region     (about GC identifiers)

Start:
118,470,492 bp from pter      End:
118,500,235 bp from pter
Size:
29,744 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: WSB2_HUMAN, Q9NYS7 (See protein sequence)
Recommended Name: WD repeat and SOCS box-containing protein 2  
Size: 404 amino acids; 45286 Da
Secondary accessions: Q9NRX9

Explore the universe of human proteins at neXtProt for WSB2: NX_Q9NYS7

Explore proteomics data for WSB2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See WSB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001265486.1  NP_001265487.1  NP_061109.1  

    ENSEMBL proteins: 
     ENSP00000319474   ENSP00000409131   ENSP00000438433   ENSP00000439450   ENSP00000445547  
     ENSP00000440386   ENSP00000444431   ENSP00000445941  

    WSB2 Human Recombinant Protein Products:

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    Novus Biologicals WSB2 Protein
    Novus Biologicals WSB2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WSB2

     
    Search eBioscience for Proteins for WSB2 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR001496 SOCS_C
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry Q9NYS7

    ProtoNet protein and cluster: Q9NYS7

    1 Blocks protein domain: IPB001496 SOCS protein

    UniProtKB/Swiss-Prot: WSB2_HUMAN, Q9NYS7
    Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different
    E3 ubiquitin ligase complexes (By similarity)
    Similarity: Contains 1 SOCS box domain
    Similarity: Contains 5 WD repeats


    Find genes that share domains with WSB2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WSB2_HUMAN, Q9NYS7
    Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3
    ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target
    proteins (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with WSB2           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for WSB2:
     Decreased viability with pacli  G2 arrest  Increased G2M DNA content  Increased cell death HMECs cel 

         1 MGI phenotypic allele for Wsb2 (no phenotypes)

    Find genes that share phenotypes with WSB2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WSB2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for WSB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WSB2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WSB2

    miRNA
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    miRTarBase miRNAs that target WSB2:
    hsa-mir-615-3p (MIRT039837), hsa-mir-29c-3p (MIRT020364)

    Block miRNA regulation of human, mouse, rat WSB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WSB2 (see all 29):
    hsa-miR-539 hsa-miR-199b-3p hsa-miR-181c hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-548v hsa-miR-181a-2* hsa-miR-221
    SwitchGear 3'UTR luciferase reporter plasmidWSB2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat WSB2

    Gene Editing
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    OriGene ORF clones in mouse, rat for WSB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WSB2 (NM_018639)
    Sino Biological Human cDNA Clone for WSB2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WSB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WSB2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for WSB2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WSB2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: WSB2_HUMAN, Q9NYS7
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WSB2
    Interactions:

        Search GeneGlobe Interaction Network for WSB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for WSB2 (Q9NYS72, 3 ENSP000003194744) via UniProtKB, MINT, STRING, and/or I2D (see all 24)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    EZH2Q159102, 3MINT-64281 I2D: score=5 
    RPN1P048432, 3MINT-63383 I2D: score=4 
    CSF3RQ990623I2D: score=1 
    CUL4AENSP000003645894STRING: ENSP00000364589
    DDB1ENSP000003017644STRING: ENSP00000301764
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--
    GO:0035556intracellular signal transduction IEA--

    Find genes that share ontologies with WSB2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WSB2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WSB2 gene (3 alternative transcripts): 
    NM_001278557.1  NM_001278558.1  NM_018639.4  

    Unigene Cluster for WSB2:

    WD repeat and SOCS box containing 2
    Hs.506985  [show with all ESTs]
    Unigene Representative Sequence: NM_018639
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000315436(uc010sza.1 uc001twr.2 uc010szb.1) ENST00000441406
    ENST00000543218 ENST00000535496 ENST00000540129(uc009zws.1) ENST00000543186
    ENST00000536738 ENST00000537945 ENST00000536602 ENST00000542726 ENST00000544233
    ENST00000542304
    miRNA
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    Block miRNA regulation of human, mouse, rat WSB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WSB2 (see all 29):
    hsa-miR-539 hsa-miR-199b-3p hsa-miR-181c hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-548v hsa-miR-181a-2* hsa-miR-221
    SwitchGear 3'UTR luciferase reporter plasmidWSB2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for WSB2
    Predesigned siRNA for gene silencing in human, mouse, rat WSB2
    Clone
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    OriGene clones in human, mouse for WSB2 (see all 7)
    OriGene ORF clones in mouse, rat for WSB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WSB2 (NM_018639)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WSB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WSB2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for WSB2
    OriGene qSTAR qPCR primer pairs in human, mouse for WSB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WSB2
      QuantiTect SYBR Green Assays in human, mouse, rat WSB2
      QuantiFast Probe-based Assays in human, mouse, rat WSB2

    Additional mRNA sequence: 

    AF038187.1 AF163324.1 AF229181.1 AK294230.1 AK295555.1 AK298513.1 AK310892.1 BC015887.2 

    16 DOTS entries:

    DT.452621  DT.95155447  DT.92454553  DT.100647480  DT.95155446  DT.92454533  DT.95155449  DT.121198321 
    DT.95155440  DT.100785043  DT.95097220  DT.95155450  DT.100030829  DT.100030831  DT.121198373  DT.95360102 

    Selected AceView cDNA sequences (see all 374):

    AA348009 AI203191 BU686896 AW074534 CA443120 BQ951451 BM680662 Z42056 
    BF589556 BU621703 AA582300 BQ003177 BM984372 BC015887 AI583144 BX420811 
    BI962505 BU782032 NM_018639 CA443344 F13379 Z45970 AW952347 AA375903 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for WSB2 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b
    SP1:                          -     -                                   -                                             
    SP2:                          -     -           -     -     -     -     -                                             
    SP3:              -     -     -                                         -                                             
    SP4:                          -     -                                   -     -                                       
    SP5:              -     -     -     -                                                                                 


    ECgene alternative splicing isoforms for WSB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WSB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTTTCAAA
    WSB2 Expression
    About this image


    WSB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Thyroid (Endocrine System)
     
     Colon (Gastrointestinal Tract)
     
     Esophagus (Gastrointestinal Tract)
    WSB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WSB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.506985
        Custom PCR Arrays for WSB2
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat WSB2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WSB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for WSB2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wsb21 , 5 WD repeat and SOCS box-containing 21, 5 88.61(n)1
    96.29(a)1
      5 (56.88 cM)5
    590431  NM_021539.41  NP_067514.21 
     1173573045 
    chicken
    (Gallus gallus)
    Aves WSB21 WD repeat and SOCS box containing 2 74.37(n)
    79.7(a)
      417023  XM_415313.4  XP_415313.3 
    lizard
    (Anolis carolinensis)
    Reptilia WSB26
    WD repeat and SOCS box containing 2
    73(a)
    1 ↔ 1
    LGb(2718498-2726728)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.114442 Transcribed sequence with moderate similarity to protein more 76.84(n)    AL869238.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wsb26
    WD repeat and SOCS box-containing 2
    45(a)
    1 ↔ 1
    5(13751951-13762969) ENSDARG00000058608
    fruit fly
    (Drosophila melanogaster)
    Insecta can6
    cannonball
    7(a)
    1 → many
    3L(10257009-10260211)
    worm
    (Caenorhabditis elegans)
    Secernentea taf-56
    Protein TAF-5 (taf-5) mRNA, complete cds
    11(a)
    1 → many
    I(7848975-7853636) WBGene00006386
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TAF56
    Subunit (90 kDa) of TFIID and SAGA complexes, invo...
    10(a)
    1 → many
    II(616127-618523) YBR198C


    ENSEMBL Gene Tree for WSB2 (if available)
    TreeFam Gene Tree for WSB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WSB2 gene
    TAF52  WSB12  TAF5L2  WDSUB12  
    6 SIMAP similar genes for WSB2 using alignment to 8 protein entries:     WSB2_HUMAN (see all proteins):
    WSB1    PF20    WDR61    WDR83    POC1B    GNB5

    Find genes that share paralogs with WSB2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for WSB2
    PGOHUM00000258742


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WSB2 (see all 606)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1891712821,2
    --118470608(+) CTCCCA/GAAGTG 1 -- ut310--------
    rs1472119791,2
    --118470673(+) CTTTTG/TTTTTT 1 -- ut310--------
    rs169481101,2
    F--118470722(+) TAACTG/TTTGTT 1 -- ut311Minor allele frequency- T:0.06MN 184
    rs1486952941,2
    --118470724(+) ACTGTC/TGTTTT 1 -- ut310--------
    rs1809568071,2
    --118470973(+) ACTACA/GTGCCA 1 -- ut310--------
    rs732179141,2
    C,F--118471390(+) TGGATC/GGGTCA 1 -- ut311Minor allele frequency- G:0.01NA 120
    rs1862030651,2
    --118471402(+) GAGCAC/TGGCCT 1 -- ut310--------
    rs1891852491,2
    --118471521(+) AACATC/GGAAGC 1 -- ut310--------
    rs1819466031,2
    --118471745(+) CTGTTC/GATAAC 1 -- ut310--------
    rs106381,2
    C,F,A,H--118471760(+) CTGAAA/GATTTA 1 -- ut3147Minor allele frequency- G:0.40NS MN NA EA WA CSA 4053

    HapMap Linkage Disequilibrium report for WSB2 (118470492 - 118500235 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for WSB2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WSB2
    DNA2.0 Custom Variant and Variant Library Synthesis for WSB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with WSB2           About GenesLikeMe

    Genetic Association Database (GAD): WSB2
    Human Genome Epidemiology (HuGE) Navigator: WSB2 (1 document)

    Export disorders for WSB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WSB2 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with WSB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The SOCS box: a tale of destruction and degradation. (PubMed id 12076535)1, 3 Kile B.T....Hilton D.J. (Trends Biochem. Sci. 2002)
    4. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    5. A whole genome screen for HIV restriction factors. (PubMed id 22082156)1 Liu L....McKnight A. (Retrovirology 2011)
    6. WD40 repeat propellers define a ubiquitin-binding domain that regulates turnover of F box proteins. (PubMed id 21070969)1 Pashkova N....Piper R.C. (Mol. Cell 2010)
    7. Regulation of interleukin-21 receptor expression and its signal transduction by WSB-2. (PubMed id 20059963)1 Nara H....Asao H. (Biochem. Biophys. Res. Commun. 2010)
    8. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    9. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55884 HGNC: 19222 AceView: WSB2 Ensembl:ENSG00000176871 euGenes: HUgn55884
    ECgene: WSB2 H-InvDB: WSB2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WSB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WSB2 gene:
    Search GeneIP for patents involving WSB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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