WSB2 Gene
protein-coding GIFtS : 50 GCID: GC12 M118470
WD repeat and SOCS box containing 2 WD repeat and SOCS box-containing 2 )
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Aliasesfor WSB2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases WD Repeat And SOCS Box Containing 2 1 2 CS Box-Containing WD Protein2 3 SBA21 2 MGC102101 WD Repeat And SOCS Box-Containing 21 2 WD Repeat And SOCS Box Containing Protein 22 WSB-22 3 WD Repeat And SOCS Box-Containing Protein 22
Export aliases for WSB2 gene to outside databases Previous GC identifers: GC12M117997 GC12M118253 GC12M116882 GC12M116933 GC12M115480
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Summariesfor WSB2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for WSB2 : This gene encodes a member of the WD-protein subfamily. The encoded protein contains five WD-repeats spanning most of the protein and an SOCS box in the C-terminus. The SOCS box may act as a bridge between specific substrate-binding domains and E3 ubiquitin protein ligases. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: WSB2_HUMAN, Q9NYS7 Function : May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitinligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity)
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Genomic Viewsfor WSB2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000012.11 NC_018923.1 NT_009775.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the WSB2 gene promoter:STAT5B STAT1 STAT4 STAT1beta STAT5A STAT1alpha PPAR-gamma1 STAT2 STAT3 PPAR-gamma2 Other transcription factors Search SABiosciences Chromatin IP Primers for WSB2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 12q24.23 Ensembl cytogenetic band: 12q24.23 HGNC cytogenetic band: 12q24.23 WSB2 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12M118470: view genomic region
(about GC identifiers )
Start: 118,470,492 bp from pter End:
118,500,235 bp from pter
Size: 29,744 bases Orientation:
minus strand
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Proteinsfor WSB2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: WSB2_HUMAN, Q9NYS7 See
protein sequence )Recommended Name: Size : 404 amino acids; 45286 DaSecondary accessions : Q9NRX9Explore the universe of human proteins at neXtProt for WSB2: NX_Q9NYS7 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9NYS7 WSB2 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_061109.1 ENSEMBL proteins: ENSP00000319474 ENSP00000409131 ENSP00000438433 ENSP00000439450 ENSP00000445547 ENSP00000440386 ENSP00000444431 ENSP00000445941 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005622 intracellular
-- --
About GeneDecksing WSB2 Antibody Products: Assay Products for WSB2:
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Protein
Domains /for WSB2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5/6 InterPro domains/families (see all 6 ):
Graphical View of Domain Structure for InterPro Entry Q9NYS7 ProtoNet protein and cluster: Q9NYS7
1 Blocks protein family : IPB001496 UniProtKB/Swiss-Prot: WSB2_HUMAN, Q9NYS7 Domain : The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3ubiquitin ligase complexes (By similarity) Similarity : Contains 1 SOCS box domainSimilarity : Contains 5 WD repeats
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Functionfor WSB2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: WSB2_HUMAN, Q9NYS7 Function : May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitinligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity)
Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: WSB2 (NM_018639 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WSB2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat WSB2
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WSB2
4 GenomeRNAi human phenotypes for WSB2 :
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Pathways & Interactionsfor WSB2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section UniProtKB/Swiss-Prot: WSB2_HUMAN, Q9NYS7 Pathway : Protein modification; protein ubiquitinationInteractions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WSB2 STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)5/7 Interacting proteins for WSB2 (Q9NYS7 2 , 3 ENSP00000319474 4 via UniProtKB, MINT, STRING , and/or I2D (see all 7 )
About this table Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016567 protein ubiquitination
IEA -- GO:0035556 intracellular signal transduction
IEA --
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Drugs & Compoundsfor WSB2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for WSB2 WSB2
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Transcriptsfor WSB2 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for WSB2 gene: NM_018639.3 Unigene Cluster for WSB2:
WD repeat and SOCS box containing 2 Hs.506985 [show with all ESTs ] Unigene Representative Sequence: NM_018639 12 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000315436 (uc010sza.1 uc001twr.2 uc010szb.1 ) ENST00000441406 ENST00000543218 ENST00000535496 ENST00000540129 (uc009zws.1 ) ENST00000543186 ENST00000536738 ENST00000537945 ENST00000536602 ENST00000542726 ENST00000544233 ENST00000542304 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: WSB2 (NM_018639 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WSB2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat WSB2
Additional cDNA sequence: AF038187.1 AF163324.1 AF229181.1 AK294230.1 AK295555.1 AK298513.1 AK310892.1 BC015887.2
16 DOTS entries : DT.452621 DT.95155447
DT.92454553 DT.100647480 DT.95155446 DT.92454533 DT.95155449 DT.121198321 DT.95155440 DT.100785043 DT.95097220 DT.95155450 DT.100030829 DT.100030831 DT.121198373 DT.95360102 24/374 AceView cDNA sequences (see all 374 ):
BM680662 BU782032 BU686078 AF038187 BM129581 BC015887 NM_018639 Z41632 CA443120 BE670535 BM978441 BU686896 AA709045 AW237744 BM984372 BU619926 AI807233 AW074534 AA682594 BM681610 AI127980 AA582300 BU782924 F04820 GeneLoc Exon Structure 5/8 Alternative Splicing Database (ASD) splice patterns (SP) for WSB2 (see all 8 ) About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b SP1 : - - - SP2 : - - - - - - - SP3 : - - - - SP4 : - - - - SP5 : - - - -
ECgene alternative splicing isoforms for WSB2
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Expression for WSB2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section WSB2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TCTTTTCAAA
About this image WSB2 expression in embryonic tissues and stem cells About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category PureStem™ progenitor T36 (Embryonic Progenitor Cell)Expression: Experimental details:
In-situ hybridization
See WSB2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for WSB2 SOURCE GeneReport for Unigene cluster: Hs.506985 SABiosciences Custom PCR Arrays for WSB2 Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WSB2
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Orthologsfor WSB2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for WSB2 gene from 4/16 species (see all 16 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves WSB21
WD repeat and SOCS box containing 2
74.37(n) 79.7(a)
417023 XM_415313.3 XP_415313.3
lizard Reptilia WSB26
--
73(a)
1 ↔ 1
LGb(2718498-2725253)
tropical clawed frog Amphibia Str.114442
Transcribed sequence with moderate similarity to protein more
76.84(n)
AL869238.2
zebrafish Actinopterygii wsb26
WD repeat and SOCS box-containing 2
45(a)
1 ↔ 1
5(13751951-13762969)
ENSEMBL Gene Tree for WSB2 (if available)TreeFam Gene Tree for WSB2 (if available)
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Paralogsfor WSB2 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for WSB2 gene CIAO1 2 WSB1 2 6 SIMAP similar genes for WSB2 using alignment to 8 protein entries: WSB2_HUMAN (see all proteins ):WSB1 PF20 WDR61 WDR83 POC1B GNB5 About GeneDecksing 1 Pseudogenes.org Pseudogene for WSB2 PGOHUM00000258742
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Genomic Variantsfor WSB2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 12 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for WSB2 (118470492 - 118500235 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for WSB2: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor WSB2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing 1 : About MalaCards colorectal cancer Human Genome Epidemiology (HuGE) Navigator: WSB2 (1 document)Export disorders for WSB2 gene to outside databases
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Publicationsfor WSB2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for WSB2 gene, integrated from 9 sources (see all 16 ):(articles sorted by number of sources associating them with WSB2) Utopia : connect your pdf to the dynamic
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) The SOCS box: a tale of destruction and degradation. (PubMed id 12076535) 1 , 3(2002) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 (2010) WD40 repeat propellers define a ubiquitin-binding dom ain that regulates turnover of F box proteins. (PubMed id 21070969) 1 (2010) Regulation of interleukin-21 receptor expression and its signal transduction by WSB-2. (PubMed id 20059963) 1 (2010) Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461) 1 (2010) Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201) 1 (2009) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 (2007) Novel role of WD40 and SOCS box protein-2 in steady-s tate distribution of granulocyte colony-stimulating factor receptor and G-CSF-c ontrolled proliferation and differentiation signaling. (PubMed id 17001306) 1 (2007) DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4- ROC1 ubiquitin ligases. (PubMed id 17079684) 1 (2006)
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External Searches for WSB2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing WSB2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing WSB2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing WSB2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for WSB2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for WSB2 gene: WSB2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor WSB2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for WSB2 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for WSB2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for WSB2 OriGene 3'-UTR Clone for WSB2 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for WSB2 OriGene Custom Protein Services for WSB2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WSB2 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
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WSB2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WSB2
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat WSB2
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Aliases for WSB2
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Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Negative
Selective marker
Curated
In-situ hybridization
