Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WSB2 Gene

Aliases for WSB2 Gene

  • WD Repeat And SOCS Box Containing 2 2 3
  • WD Repeat And SOCS Box-Containing 2 2 3
  • CS Box-Containing WD Protein 3 4
  • WSB-2 3 4
  • WD Repeat And SOCS Box Containing Protein 2 3
  • WD Repeat And SOCS Box-Containing Protein 2 3
  • SBA2 3

External Ids for WSB2 Gene

Previous GeneCards Identifiers for WSB2 Gene

  • GC12M117997
  • GC12M118253
  • GC12M116882
  • GC12M116933
  • GC12M118470
  • GC12M115480

Summaries for WSB2 Gene

Entrez Gene Summary for WSB2 Gene

  • This gene encodes a member of the WD-protein subfamily. The encoded protein contains five WD-repeats spanning most of the protein and an SOCS box in the C-terminus. The SOCS box may act as a bridge between specific substrate-binding domains and E3 ubiquitin protein ligases. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

GeneCards Summary for WSB2 Gene

WSB2 (WD Repeat And SOCS Box Containing 2) is a Protein Coding gene. An important paralog of this gene is TAF5L.

UniProtKB/Swiss-Prot for WSB2 Gene

  • May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WSB2 Gene

Genomics for WSB2 Gene

Regulatory Elements for WSB2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WSB2 Gene

Start:
118,032,687 bp from pter
End:
118,062,430 bp from pter
Size:
29,744 bases
Orientation:
Minus strand

Genomic View for WSB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WSB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WSB2 Gene

Proteins for WSB2 Gene

  • Protein details for WSB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYS7-WSB2_HUMAN
    Recommended name:
    WD repeat and SOCS box-containing protein 2
    Protein Accession:
    Q9NYS7
    Secondary Accessions:
    • B4DIE6
    • B4DPV6
    • Q9NRX9

    Protein attributes for WSB2 Gene

    Size:
    404 amino acids
    Molecular mass:
    45286 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WSB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WSB2 Gene

Proteomics data for WSB2 Gene at MOPED

Post-translational modifications for WSB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WSB2 Gene

Domains for WSB2 Gene

Gene Families for WSB2 Gene

HGNC:
  • WDR :WD repeat domain containing

Graphical View of Domain Structure for InterPro Entry

Q9NYS7

UniProtKB/Swiss-Prot:

WSB2_HUMAN :
  • Q9NYS7
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Contains 1 SOCS box domain.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WSB2: view

Function for WSB2 Gene

Molecular function for WSB2 Gene

UniProtKB/Swiss-Prot Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for WSB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with WSB2: view

Phenotypes for WSB2 Gene

genes like me logo Genes that share phenotypes with WSB2: view

Animal Model Products

CRISPR Products

miRNA for WSB2 Gene

miRTarBase miRNAs that target WSB2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WSB2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for WSB2 Gene

Localization for WSB2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WSB2 Gene COMPARTMENTS Subcellular localization image for WSB2 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WSB2 Gene

Pathways for WSB2 Gene

SuperPathways for WSB2 Gene

No Data Available

UniProtKB/Swiss-Prot Q9NYS7-WSB2_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for WSB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with WSB2: view

No data available for Pathways by source for WSB2 Gene

Transcripts for WSB2 Gene

Unigene Clusters for WSB2 Gene

WD repeat and SOCS box containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WSB2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WSB2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b
SP1: - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - -
SP6: - - -
SP7: - -
SP8:

Relevant External Links for WSB2 Gene

GeneLoc Exon Structure for
WSB2
ECgene alternative splicing isoforms for
WSB2

Expression for WSB2 Gene

mRNA expression in normal human tissues for WSB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for WSB2 Gene

SOURCE GeneReport for Unigene cluster for WSB2 Gene Hs.506985

genes like me logo Genes that share expressions with WSB2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WSB2 Gene

Orthologs for WSB2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WSB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WSB2 35
  • 99.59 (n)
  • 99.75 (a)
WSB2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WSB2 35
  • 92.29 (n)
  • 98.51 (a)
WSB2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WSB2 35
  • 92.64 (n)
  • 98.01 (a)
WSB2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wsb2 35
  • 88.61 (n)
  • 96.29 (a)
Wsb2 16
Wsb2 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WSB2 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WSB2 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wsb2 35
  • 87.21 (n)
  • 95.05 (a)
chicken
(Gallus gallus)
Aves WSB2 35
  • 74.37 (n)
  • 79.7 (a)
WSB2 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WSB2 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11444 35
wsb2 35
  • 69.01 (n)
  • 73.37 (a)
zebrafish
(Danio rerio)
Actinopterygii wsb2 36
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta can 36
  • 7 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea taf-5 36
  • 11 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF5 36
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for WSB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WSB2 Gene

ENSEMBL:
Gene Tree for WSB2 (if available)
TreeFam:
Gene Tree for WSB2 (if available)

Paralogs for WSB2 Gene

Paralogs for WSB2 Gene

Selected SIMAP similar genes for WSB2 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for WSB2 Gene

genes like me logo Genes that share paralogs with WSB2: view

Variants for WSB2 Gene

Sequence variations from dbSNP and Humsavar for WSB2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs10638 -- 118,033,955(+) CTGAA(A/G)ATTTA utr-variant-3-prime
rs13649 -- 118,033,658(+) GCTCC(A/G)GGAAA utr-variant-3-prime
rs3087921 -- 118,032,917(+) AACTG(G/T)TTGTT utr-variant-3-prime
rs4131122 -- 118,059,383(+) TGGTC(C/G)GGGCT intron-variant
rs4767655 -- 118,055,717(+) TCAAG(A/C)AATTC intron-variant

Relevant External Links for WSB2 Gene

HapMap Linkage Disequilibrium report
WSB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for WSB2 Gene

Disorders for WSB2 Gene

Relevant External Links for WSB2

Genetic Association Database (GAD)
WSB2
Human Genome Epidemiology (HuGE) Navigator
WSB2
genes like me logo Genes that share disorders with WSB2: view

No data available for UniProtKB/Swiss-Prot for WSB2 Gene

Publications for WSB2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  5. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L. … McKnight A. (Retrovirology 2011) 3

Products for WSB2 Gene

Sources for WSB2 Gene

Back to Top

Content