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Aliases for WSB2 Gene

Aliases for WSB2 Gene

  • WD Repeat And SOCS Box Containing 2 2 3 5
  • CS Box-Containing WD Protein 3 4
  • WSB-2 3 4
  • WD Repeat And SOCS Box-Containing Protein 2 3
  • WD Repeat And SOCS Box-Containing 2 2
  • SBA2 3

External Ids for WSB2 Gene

Previous GeneCards Identifiers for WSB2 Gene

  • GC12M117997
  • GC12M118253
  • GC12M116882
  • GC12M116933
  • GC12M118470
  • GC12M115480

Summaries for WSB2 Gene

Entrez Gene Summary for WSB2 Gene

  • This gene encodes a member of the WD-protein subfamily. The encoded protein contains five WD-repeats spanning most of the protein and an SOCS box in the C-terminus. The SOCS box may act as a bridge between specific substrate-binding domains and E3 ubiquitin protein ligases. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

GeneCards Summary for WSB2 Gene

WSB2 (WD Repeat And SOCS Box Containing 2) is a Protein Coding gene. An important paralog of this gene is WSB1.

UniProtKB/Swiss-Prot for WSB2 Gene

  • May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WSB2 Gene

Genomics for WSB2 Gene

Regulatory Elements for WSB2 Gene

Enhancers for WSB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G118015 1.1 ENCODE 18.5 +45.4 45367 2.2 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 SUDS3 RFC5 WSB2 ENSG00000277873
GH12G118058 1.6 FANTOM5 ENCODE dbSUPER 8.8 +0.5 505 6.9 HDGF FOXA2 ARNT ARID4B SIN3A FEZF1 YY1 ZNF766 SMARCB1 ZNF592 VSIG10 RFC5 RPS2P5 SUDS3 WSB2 PIR34670 GC12P118041
GH12G118051 1.6 Ensembl ENCODE dbSUPER 8.6 +8.4 8353 6.1 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS RFC5 WSB2 PIR34670 GC12P118041
GH12G118033 0.8 ENCODE 17.2 +27.9 27872 2.0 CTCF KLF1 JUN TEAD4 RAD21 TEAD3 ARID3A POLR2A SMC3 ZNF143 WSB2 RFC5 ENSG00000276292 ENSG00000277873
GH12G118134 1.1 ENCODE 11.2 -75.0 -75016 5.3 HDGF HNRNPUL1 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B VSIG10 RFC5 WSB2 SUDS3 PEBP1 GC12M118176
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WSB2 on UCSC Golden Path with GeneCards custom track

Promoters for WSB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000058150 1130 3401 HDGF ARNT SIN3A FEZF1 YY1 ZNF766 GLIS2 NCOA1 REST TSHZ1

Genomic Location for WSB2 Gene

Chromosome:
12
Start:
118,032,687 bp from pter
End:
118,062,430 bp from pter
Size:
29,744 bases
Orientation:
Minus strand

Genomic View for WSB2 Gene

Genes around WSB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WSB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WSB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WSB2 Gene

Proteins for WSB2 Gene

  • Protein details for WSB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYS7-WSB2_HUMAN
    Recommended name:
    WD repeat and SOCS box-containing protein 2
    Protein Accession:
    Q9NYS7
    Secondary Accessions:
    • B4DIE6
    • B4DPV6
    • Q9NRX9

    Protein attributes for WSB2 Gene

    Size:
    404 amino acids
    Molecular mass:
    45286 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WSB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WSB2 Gene

Post-translational modifications for WSB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WSB2 Gene

Domains & Families for WSB2 Gene

Gene Families for WSB2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYS7

UniProtKB/Swiss-Prot:

WSB2_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
genes like me logo Genes that share domains with WSB2: view

Function for WSB2 Gene

Molecular function for WSB2 Gene

UniProtKB/Swiss-Prot Function:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
genes like me logo Genes that share phenotypes with WSB2: view

Animal Models for WSB2 Gene

MGI Knock Outs for WSB2:
  • Wsb2 tm1b(EUCOMM)Hmgu

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WSB2 Gene

Localization for WSB2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WSB2 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for WSB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with WSB2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WSB2 Gene

Pathways & Interactions for WSB2 Gene

No Data Available

UniProtKB/Swiss-Prot Q9NYS7-WSB2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for WSB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with WSB2: view

No data available for Pathways by source and SIGNOR curated interactions for WSB2 Gene

Drugs & Compounds for WSB2 Gene

No Compound Related Data Available

Transcripts for WSB2 Gene

Unigene Clusters for WSB2 Gene

WD repeat and SOCS box containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WSB2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b
SP1: - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - -
SP6: - - -
SP7: - -
SP8:

Relevant External Links for WSB2 Gene

GeneLoc Exon Structure for
WSB2
ECgene alternative splicing isoforms for
WSB2

Expression for WSB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WSB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WSB2 Gene

This gene is overexpressed in Spinal cord (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WSB2 Gene



Protein tissue co-expression partners for WSB2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WSB2 Gene:

WSB2

SOURCE GeneReport for Unigene cluster for WSB2 Gene:

Hs.506985

Evidence on tissue expression from TISSUES for WSB2 Gene

  • Nervous system(4.9)
  • Lung(3.3)
  • Kidney(2)
genes like me logo Genes that share expression patterns with WSB2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WSB2 Gene

Orthologs for WSB2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WSB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WSB2 34 35
  • 99.59 (n)
dog
(Canis familiaris)
Mammalia WSB2 34 35
  • 92.64 (n)
cow
(Bos Taurus)
Mammalia WSB2 34 35
  • 92.29 (n)
oppossum
(Monodelphis domestica)
Mammalia WSB2 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wsb2 34 16 35
  • 88.61 (n)
rat
(Rattus norvegicus)
Mammalia Wsb2 34
  • 87.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WSB2 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves WSB2 34 35
  • 74.37 (n)
lizard
(Anolis carolinensis)
Reptilia WSB2 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wsb2 34
  • 69.01 (n)
Str.11444 34
zebrafish
(Danio rerio)
Actinopterygii wsb2 35
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta can 35
  • 7 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea taf-5 35
  • 11 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF5 35
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToMany
Species where no ortholog for WSB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WSB2 Gene

ENSEMBL:
Gene Tree for WSB2 (if available)
TreeFam:
Gene Tree for WSB2 (if available)

Paralogs for WSB2 Gene

(6) SIMAP similar genes for WSB2 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for WSB2 Gene

genes like me logo Genes that share paralogs with WSB2: view

Variants for WSB2 Gene

Sequence variations from dbSNP and Humsavar for WSB2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000020880 -- 118,062,828(+) TAACT(G/T)TAGCA upstream-variant-2KB
rs1000209611 -- 118,042,103(+) TGGAA(C/T)TCCTT intron-variant
rs1000366007 -- 118,060,928(+) GTCCA(A/G)CCCCC intron-variant
rs1000441297 -- 118,048,219(+) CCACC(A/G)CACCC intron-variant
rs1000793519 -- 118,057,640(+) TATAT(G/T)TATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WSB2 Gene

Variant ID Type Subtype PubMed ID
esv25263 CNV gain 19812545
esv3581916 CNV gain 25503493
esv3630882 CNV loss 21293372
nsv1071058 CNV deletion 25765185
nsv1126323 CNV deletion 24896259
nsv560388 CNV loss 21841781

Variation tolerance for WSB2 Gene

Residual Variation Intolerance Score: 35.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.63; 45.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WSB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WSB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WSB2 Gene

Disorders for WSB2 Gene

Relevant External Links for WSB2

Genetic Association Database (GAD)
WSB2
Human Genome Epidemiology (HuGE) Navigator
WSB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WSB2

No disorders were found for WSB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WSB2 Gene

Publications for WSB2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3 64
  4. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3 64
  5. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L. … McKnight A. (Retrovirology 2011) 3 64

Products for WSB2 Gene

Sources for WSB2 Gene

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