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WSB1 Gene

protein-coding   GIFtS: 61
GCID: GC17P025621

WD Repeat And SOCS Box Containing 1

(Previous name: WD repeat and SOCS box-containing 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
WD Repeat And SOCS Box Containing 11 2
SWIP12 3 5
WD Repeat And SOCS Box-Containing 11 2
WSB-12 3
SOCS Box-Containing WD Protein SWiP-12 3
WD Repeat And SOCS Box-Containing Protein 12

External Ids:    HGNC: 192211   Entrez Gene: 261182   Ensembl: ENSG000001090467   OMIM: 6100915   UniProtKB: Q9Y6I73   
ORGUL members:         

Export aliases for WSB1 gene to outside databases

Previous GC identifers: GC17P025476 GC17P027520 GC17P025766 GC17P022645 GC17P021829


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WSB1 Gene:
This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and
chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus.
Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. (provided by
RefSeq, Jul 2008)

GeneCards Summary for WSB1 Gene:
WSB1 (WD repeat and SOCS box containing 1) is a protein-coding gene. Diseases associated with WSB1 include dental caries, and uterine fibroid. An important paralog of this gene is TAF5.

UniProtKB/Swiss-Prot: WSB1_HUMAN, Q9Y6I7
Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3
ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target
proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through
proteasomal degradation

Gene Wiki entry for WSB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WSB1 gene promoter:
         AML1a   Nkx2-2   XBP-1   CUTL1   Evi-1   RORalpha2   Gfi-1   POU2F1   POU2F1a   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWSB1 promoter sequence
   Search Chromatin IP Primers for WSB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WSB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.1   Ensembl cytogenetic band:  17q11.1   HGNC cytogenetic band: 17q11.2

WSB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WSB1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P025621:  view genomic region     (about GC identifiers)

Start:
25,621,102 bp from pter      End:
25,640,657 bp from pter
Size:
19,556 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: WSB1_HUMAN, Q9Y6I7 (See protein sequence)
Recommended Name: WD repeat and SOCS box-containing protein 1  
Size: 421 amino acids; 47432 Da
Subunit: Interacts with DIO2. Component of the probable ECS(WSB1) E3 ubiquitin ligase complex which contains CUL5,
RNF7/RBX2, Elongin BC complex and WSB1. Component of a probable ECS-like E3 ubiquitin-protein ligase complex
which contains CUL5, RBX1, Elongin BC complex and WSB1. Interacts with CUL5, RNF7, TCEB1 and TCEB2. Binds to
HIPK2 through WD40 repeats
Secondary accessions: Q9NRB1 Q9UBH9 Q9UG25 Q9UNN6 Q9Y656
Alternative splicing: 4 isoforms:  Q9Y6I7-1   Q9Y6I7-2   Q9Y6I7-3   Q9Y6I7-4   

Explore the universe of human proteins at neXtProt for WSB1: NX_Q9Y6I7

Explore proteomics data for WSB1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys208
  • Modification sites at PhosphoSitePlus

  • See WSB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_056441.6  NP_599027.1  

    ENSEMBL proteins: 
     ENSP00000462737   ENSP00000262394   ENSP00000462365   ENSP00000461991   ENSP00000462595  
     ENSP00000464109   ENSP00000416112   ENSP00000327055   ENSP00000463621   ENSP00000462900  
    Reactome Protein details: Q9Y6I7

    WSB1 Human Recombinant Protein Products:

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    Novus Biologicals WSB1 Proteins
    Novus Biologicals WSB1 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WSB1

    WSB1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for WSB1
    Cloud-Clone Corp. Antibodies for WSB1
    ThermoFisher Antibodies for WSB1
    Search LSBio for Antibodies for WSB1

    WSB1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for WSB1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for WSB1
    Cloud-Clone Corp. CLIAs for WSB1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR001496 SOCS_C
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y6I7

    ProtoNet protein and cluster: Q9Y6I7

    1 Blocks protein domain: IPB001496 SOCS protein

    UniProtKB/Swiss-Prot: WSB1_HUMAN, Q9Y6I7
    Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different
    E3 ubiquitin ligase complexes (By similarity)
    Similarity: Contains 1 SOCS box domain
    Similarity: Contains 6 WD repeats


    WSB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WSB1_HUMAN, Q9Y6I7
    Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3
    ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target
    proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through
    proteasomal degradation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18093972
         
    WSB1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for WSB1:
     Increased cell death in HCC-19 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WSB1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for WSB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WSB1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WSB1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat WSB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WSB1 (see all 42):
    hsa-miR-4307 hsa-miR-15a hsa-miR-513a-5p hsa-miR-503 hsa-miR-128 hsa-miR-374c hsa-miR-1184 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidWSB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for WSB1
    Predesigned siRNA for gene silencing in human, mouse, rat WSB1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for WSB1

    Clone
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    OriGene clones in human, mouse for WSB1 (see all 13)
    OriGene ORF clones in mouse, rat for WSB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): WSB1 (NM_134265)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WSB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WSB1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for WSB1
    Browse ESI BIO Cell Lines and PureStem Progenitors for WSB1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WSB1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--

    WSB1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WSB1 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for WSB1
        Antigen processing: Ubiquitination & Proteasome degradation


    UniProtKB/Swiss-Prot: WSB1_HUMAN, Q9Y6I7
    Pathway: Protein modification; protein ubiquitination


    WSB1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including WSB1: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for WSB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WSB1 (Q9Y6I71, 2, 3 ENSP000002623944) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSK3BP498412, 3MINT-8257823 I2D: score=2 
    TCEB2Q153703, ENSP000002623064I2D: score=2 STRING: ENSP00000262306
    CFTRP135693, ENSP000000030844I2D: score=1 STRING: ENSP00000003084
    TCEB1Q153693, ENSP000002848114I2D: score=2 STRING: ENSP00000284811
    HIPK2Q9H2X63I2D: score=3 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0016567protein ubiquitination IEA--
    GO:0035556intracellular signal transduction IEA--

    WSB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WSB1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for WSB1 gene (3 alternative transcripts): 
    NM_015626.8  NM_134265.2  NM_134264.2  

    Unigene Cluster for WSB1:

    WD repeat and SOCS box containing 1
    Hs.446017  [show with all ESTs]
    Unigene Representative Sequence: NM_015626
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000581440 ENST00000578312 ENST00000262394(uc002gzd.1 uc002gze.1)
    ENST00000583742 ENST00000467843(uc010vzz.1 uc010crf.1 uc002gzf.1)
    ENST00000579733 ENST00000583193 ENST00000583786 ENST00000584354 ENST00000581185(uc010vzy.1)
    ENST00000427287 ENST00000581089 ENST00000348811 ENST00000582208 ENST00000584114
    ENST00000487603 ENST00000583096
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat WSB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WSB1 (see all 42):
    hsa-miR-4307 hsa-miR-15a hsa-miR-513a-5p hsa-miR-503 hsa-miR-128 hsa-miR-374c hsa-miR-1184 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidWSB1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for WSB1
    Predesigned siRNA for gene silencing in human, mouse, rat WSB1
    Clone
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    OriGene clones in human, mouse for WSB1 (see all 13)
    OriGene ORF clones in mouse, rat for WSB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): WSB1 (NM_134265)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WSB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WSB1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for WSB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WSB1
      QuantiTect SYBR Green Assays in human, mouse, rat WSB1
      QuantiFast Probe-based Assays in human, mouse, rat WSB1

    Additional mRNA sequence: 

    AF069313.2 AF072880.1 AF106683.1 AF106684.1 AF112205.1 AF147442.1 AF240696.1 AK057082.1 
    AK074917.1 AK222576.1 AK294516.1 AK300262.1 AK307114.1 AL110243.1 BC005226.1 BC021110.1 

    Selected DOTS entries (see all 37):

    DT.86999091  DT.95292242  DT.92337392  DT.120948116  DT.86835765  DT.100038369  DT.99939174  DT.92452701 
    DT.75147874  DT.100828087  DT.120948113  DT.120948026  DT.95170822  DT.120948121  DT.120948094  DT.97768910 
    DT.92452698  DT.120948048  DT.120948096  DT.120948097  DT.120948124  DT.120948000  DT.120948046  DT.100828086 

    Selected AceView cDNA sequences (see all 687):

    BM931349 BQ632434 AW009136 AI922528 AL702944 AI376804 BF059561 AA992406 
    AA987973 BP871486 AL698818 AA485034 AA021659 AA693918 AI537299 AW207570 
    CA314532 BV180039 BV176639 AW136116 AW129027 AW129289 NM_134265 AA233311 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for WSB1 (see all 17)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d ·
    SP1:                                -     -                 -     -     -                                                           -     -     -     -     -   
    SP2:                                -     -     -     -     -     -     -     -     -     -     -                                   -     -     -     -     -   
    SP3:                                                                                                                                -                           
    SP4:                                                                                                                                -     -     -     -     -   
    SP5:                                                                                                                                -                           

    ExUns: 8e ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
    SP1:  -     -     -                           
    SP2:  -     -     -                           
    SP3:  -     -                                 
    SP4:  -     -     -                           
    SP5:  -     -     -                           


    ECgene alternative splicing isoforms for WSB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WSB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTTAAAAA
    WSB1 Expression
    About this image


    WSB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mandibular Condyle
     
     Eye (Sensory Organs)
             Retina
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    WSB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WSB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.446017
        Pathway & Disease-focused RT2 Profiler PCR Array including WSB1: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for WSB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WSB1
    QuantiTect SYBR Green Assays in human, mouse, rat WSB1
    QuantiFast Probe-based Assays in human, mouse, rat WSB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WSB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for WSB1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wsb11 , 5 WD repeat and SOCS box-containing 11, 5 90.32(n)1
    92.86(a)1
      11 (46.74 cM)5
    788891  NM_019653.31  NP_062627.31 
     792393725 
    chicken
    (Gallus gallus)
    Aves WSB11 WD repeat and SOCS box containing 1 81.95(n)
    88.36(a)
      395685  NM_204872.1  NP_990203.1 
    lizard
    (Anolis carolinensis)
    Reptilia WSB16
    WD repeat and SOCS box containing 1
    78(a)
    1 ↔ 1
    GL343543.1(251944-277243)
    African clawed frog
    (Xenopus laevis)
    Amphibia wsb1-pending-prov2 SOCS box-containing WD protein SWiP-1 79.96(n)    BC042278.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb92g112 wufb92g11 75.87(n)   323226  BC054567.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta can6
    cannonball
    7(a)
    1 → many
    3L(10257009-10260211)
    worm
    (Caenorhabditis elegans)
    Secernentea taf-56
    Protein TAF-5 (taf-5) mRNA, complete cds
    11(a)
    1 → many
    I(7848975-7853636) WBGene00006386
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SKI8(YGL213C)4 Ski complex component and WD-repeat protein, mediates more   --   7(91247-90054) 852659  NP_011302.1 


    ENSEMBL Gene Tree for WSB1 (if available)
    TreeFam Gene Tree for WSB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WSB1 gene
    TAF52  WSB22  TAF5L2  WDSUB12  
    Selected SIMAP similar genes for WSB1 using alignment to 10 protein entries:     WSB1_HUMAN (see all proteins) (see all similar genes):
    WSB2    CORO7    GNB5    SMU1    WDR61    RBBP7
    WDR88    IFT122    DKFZp762M0115    PAFAH1B1    STRN3    CIAO1
    DAW1    WDR48    WDR83    RBBP4    FBXW11    STRN4

    WSB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WSB1 (see all 441)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1457386081,2
    --21826478(+) TATGGC/TATAGT 2 -- us2k10--------
    rs1813597391,2
    --25619279(+) AACCTC/GTGCCT 2 -- us2k10--------
    rs1510446071,2
    --25619309(+) CCTGCA/CTTAGC 2 -- us2k10--------
    rs620585621,2
    C,F--25619341(+) GCCACT/CACGCC 2 -- us2k17Minor allele frequency- C:0.32WA NA EA 366
    rs1867296851,2
    --25619343(+) CACTAC/TGCCTG 2 -- us2k10--------
    rs1403907321,2
    --25619350(+) CCTGGA/CTAATT 2 -- us2k10--------
    rs1903896791,2
    --25619503(+) AAGACA/GAGGGG 2 -- us2k10--------
    rs1456059161,2
    --25619690(+) CTCGGA/GAGGCT 2 -- us2k10--------
    rs679456441,2
    C--25619802(+) AAAAAT/AAAATA 2 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1819444741,2
    --25619828(+) AAAAAA/CAAAAG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for WSB1 (25621102 - 25640657 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for WSB1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv540e199CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WSB1
    DNA2.0 Custom Variant and Variant Library Synthesis for WSB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610091    OMIM disorders: --

    12 diseases for WSB1:    
    About MalaCards
    dental caries    uterine fibroid    cleft lip    chronic myeloid leukemia
    intellectual disability    myeloid leukemia    neuroblastoma    pancreatic cancer
    pancreatitis    thyroiditis    leukemia    endotheliitis


    WSB1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): WSB1
    Human Genome Epidemiology (HuGE) Navigator: WSB1 (2 documents)

    Export disorders for WSB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WSB1 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with WSB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SWiP-1: novel SOCS box containing WD-protein regulated by signalling centres and by Shh during development. (PubMed id 10354473)1, 2, 3 Vasiliauskas D.... Stern C.D. (Mech. Dev. 1999)
    2. Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1. (PubMed id 18093972)1, 2 Choi D.W.... Choi C.Y. (J. Biol. Chem. 2008)
    3. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (Genet. Med. 2008)
    4. The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate. (PubMed id 15965468)1, 2 Dentice M.... Bianco A.C. (Nat. Cell Biol. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The SOCS box: a tale of destruction and degradation. (PubMed id 12076535)1, 3 Kile B.T....Hilton D.J. (Trends Biochem. Sci. 2002)
    7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    8. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    9. GWAS of dental caries patterns in the permanent dentition. (PubMed id 23064961)1 Shaffer J.R....Marazita M.L. (J. Dent. Res. 2013)
    10. HIF1 regulates WSB-1 expression to promote hypoxia-induced chemoresistance in hepatocellular carcinoma cells. (PubMed id 23792163)1 Tong Y....Xia Q. (FEBS Lett. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26118 HGNC: 19221 AceView: WSB1 Ensembl:ENSG00000109046 euGenes: HUgn26118
    ECgene: WSB1 H-InvDB: WSB1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for WSB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for WSB1 gene:
    Search GeneIP for patents involving WSB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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