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Aliases for WSB1 Gene

Aliases for WSB1 Gene

  • WD Repeat And SOCS Box Containing 1 2 3 5
  • SOCS Box-Containing WD Protein SWiP-1 3 4
  • WD Repeat And SOCS Box-Containing 1 2 3
  • SWIP1 3 4
  • WSB-1 3 4

External Ids for WSB1 Gene

Previous GeneCards Identifiers for WSB1 Gene

  • GC17P025476
  • GC17P027520
  • GC17P025766
  • GC17P022645
  • GC17P025621
  • GC17P021829

Summaries for WSB1 Gene

Entrez Gene Summary for WSB1 Gene

  • This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for WSB1 Gene

WSB1 (WD Repeat And SOCS Box Containing 1) is a Protein Coding gene. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. An important paralog of this gene is WDSUB1.

UniProtKB/Swiss-Prot for WSB1 Gene

  • Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation.

Gene Wiki entry for WSB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WSB1 Gene

Genomics for WSB1 Gene

Regulatory Elements for WSB1 Gene

Promoters for WSB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WSB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for WSB1 Gene

Chromosome:
17
Start:
27,294,076 bp from pter
End:
27,315,926 bp from pter
Size:
21,851 bases
Orientation:
Plus strand

Genomic View for WSB1 Gene

Genes around WSB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WSB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WSB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WSB1 Gene

Proteins for WSB1 Gene

  • Protein details for WSB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6I7-WSB1_HUMAN
    Recommended name:
    WD repeat and SOCS box-containing protein 1
    Protein Accession:
    Q9Y6I7
    Secondary Accessions:
    • Q9NRB1
    • Q9UBH9
    • Q9UG25
    • Q9UNN6
    • Q9Y656

    Protein attributes for WSB1 Gene

    Size:
    421 amino acids
    Molecular mass:
    47432 Da
    Quaternary structure:
    • Interacts with DIO2. Component of the probable ECS(WSB1) E3 ubiquitin ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and WSB1. Component of a probable ECS-like E3 ubiquitin-protein ligase complex which contains CUL5, RBX1, Elongin BC complex and WSB1. Interacts with CUL5, RNF7, TCEB1 and TCEB2. Binds to HIPK2 through WD40 repeats.

    Alternative splice isoforms for WSB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WSB1 Gene

Proteomics data for WSB1 Gene at MOPED

Post-translational modifications for WSB1 Gene

  • Ubiquitination at Lys 208
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for WSB1 Gene

Domains & Families for WSB1 Gene

Gene Families for WSB1 Gene

Suggested Antigen Peptide Sequences for WSB1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y6I7

UniProtKB/Swiss-Prot:

WSB1_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Contains 6 WD repeats.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Contains 1 SOCS box domain.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with WSB1: view

Function for WSB1 Gene

Molecular function for WSB1 Gene

UniProtKB/Swiss-Prot Function:
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation.

Gene Ontology (GO) - Molecular Function for WSB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
genes like me logo Genes that share ontologies with WSB1: view
genes like me logo Genes that share phenotypes with WSB1: view

Animal Model Products

miRNA for WSB1 Gene

miRTarBase miRNAs that target WSB1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WSB1 Gene

Localization for WSB1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WSB1 Gene COMPARTMENTS Subcellular localization image for WSB1 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2
endoplasmic reticulum 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WSB1 Gene

Pathways & Interactions for WSB1 Gene

genes like me logo Genes that share pathways with WSB1: view

UniProtKB/Swiss-Prot Q9Y6I7-WSB1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for WSB1 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for WSB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with WSB1: view

Drugs & Compounds for WSB1 Gene

No Compound Related Data Available

Transcripts for WSB1 Gene

Unigene Clusters for WSB1 Gene

WD repeat and SOCS box containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WSB1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - - - - - - -
SP3: -
SP4: - - - - -
SP5: -
SP6: - -
SP7: -
SP8:
SP9: - - - -
SP10: - - - - - - - - - - - -
SP11: - - - - - - - - -
SP12:
SP13: - - - -
SP14: - - - - - -
SP15: - - - - - - - - - - - - - -
SP16: - - - - - - -
SP17: - -

ExUns: 8e ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: - - -
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for WSB1 Gene

GeneLoc Exon Structure for
WSB1
ECgene alternative splicing isoforms for
WSB1

Expression for WSB1 Gene

mRNA expression in normal human tissues for WSB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WSB1 Gene



SOURCE GeneReport for Unigene cluster for WSB1 Gene Hs.446017

genes like me logo Genes that share expression patterns with WSB1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for WSB1 Gene

Orthologs for WSB1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WSB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WSB1 35
  • 94.93 (n)
  • 97.86 (a)
WSB1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WSB1 35
  • 95.57 (n)
  • 98.81 (a)
WSB1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wsb1 35
  • 90.32 (n)
  • 92.86 (a)
Wsb1 16
Wsb1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WSB1 35
  • 99.52 (n)
  • 99.29 (a)
WSB1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wsb1 35
  • 90.34 (n)
  • 93.35 (a)
oppossum
(Monodelphis domestica)
Mammalia WSB1 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
chicken
(Gallus gallus)
Aves WSB1 35
  • 81.95 (n)
  • 88.36 (a)
SWIP-1 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WSB1 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75613 35
wsb1 35
  • 77.86 (n)
  • 82.86 (a)
African clawed frog
(Xenopus laevis)
Amphibia wsb1-pending-prov 35
zebrafish
(Danio rerio)
Actinopterygii wsb1 35
  • 68.73 (n)
  • 75.24 (a)
wufb92g11 35
wsb1 36
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta can 36
  • 7 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea taf-5 36
  • 11 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF5 36
  • 10 (a)
OneToMany
SKI8 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for WSB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WSB1 Gene

ENSEMBL:
Gene Tree for WSB1 (if available)
TreeFam:
Gene Tree for WSB1 (if available)

Paralogs for WSB1 Gene

Paralogs for WSB1 Gene

genes like me logo Genes that share paralogs with WSB1: view

Variants for WSB1 Gene

Sequence variations from dbSNP and Humsavar for WSB1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs6561 -- 27,301,794(+) GAGAT(C/T)ACGTA intron-variant, reference, missense
rs9867 -- 27,312,515(-) AAAAG(C/T)TCAAC utr-variant-3-prime
rs1060618 -- 27,313,055(+) AAAAA(A/G)TTGTG utr-variant-3-prime
rs2270760 -- 27,303,726(-) AGTAA(C/G)CTGAA intron-variant
rs2270761 -- 27,303,362(-) ACTGG(A/G)GTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WSB1 Gene

Variant ID Type Subtype PubMed ID
dgv540e199 CNV Deletion 23128226

Variation tolerance for WSB1 Gene

Residual Variation Intolerance Score: 19.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.49; 91.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WSB1 Gene

HapMap Linkage Disequilibrium report
WSB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WSB1 Gene

Disorders for WSB1 Gene

Relevant External Links for WSB1

Genetic Association Database (GAD)
WSB1
Human Genome Epidemiology (HuGE) Navigator
WSB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WSB1

No disorders were found for WSB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WSB1 Gene

Publications for WSB1 Gene

  1. SWiP-1: novel SOCS box containing WD-protein regulated by signalling centres and by Shh during development. (PMID: 10354473) Vasiliauskas D. … Stern C.D. (Mech. Dev. 1999) 2 3 4 67
  2. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3
  3. Potential role of WSB1 isoforms in growth and survival of neuroblastoma cells. (PMID: 24441107) Shichrur K. … Avigad S. (Pediatr. Res. 2014) 3
  4. Minimal requirements for ubiquitination-mediated regulation of thyroid hormone activation. (PMID: 25074266) Egri P. … Gereben B. (J. Mol. Endocrinol. 2014) 3
  5. GWAS of dental caries patterns in the permanent dentition. (PMID: 23064961) Shaffer J.R. … Marazita M.L. (J. Dent. Res. 2013) 3

Products for WSB1 Gene

Sources for WSB1 Gene

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