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Aliases for WSB1 Gene

Aliases for WSB1 Gene

  • WD Repeat And SOCS Box Containing 1 2 3 5
  • SOCS Box-Containing WD Protein SWiP-1 3 4
  • SWIP1 3 4
  • WSB-1 3 4
  • WD Repeat And SOCS Box-Containing Protein 1 3
  • WD Repeat And SOCS Box-Containing 1 2

External Ids for WSB1 Gene

Previous GeneCards Identifiers for WSB1 Gene

  • GC17P025476
  • GC17P027520
  • GC17P025766
  • GC17P022645
  • GC17P025621
  • GC17P021829

Summaries for WSB1 Gene

Entrez Gene Summary for WSB1 Gene

  • This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for WSB1 Gene

WSB1 (WD Repeat And SOCS Box Containing 1) is a Protein Coding gene. Among its related pathways are Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is WSB2.

UniProtKB/Swiss-Prot for WSB1 Gene

  • Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation.

Gene Wiki entry for WSB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WSB1 Gene

Genomics for WSB1 Gene

Regulatory Elements for WSB1 Gene

Enhancers for WSB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F027237 1 FANTOM5 ENCODE 31.4 -51.8 -51837 8.8 PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A YY1 ZNF143 FOS SP3 SP5 WSB1 ITM2BP1 LGALS9 ENSG00000265246 RPL34P31
GH17F027246 0.2 ENCODE 24.9 -46.5 -46477 1.3 PKNOX1 ARID4B SIN3A FEZF1 ZNF48 YY1 ZNF143 PPARG KAT8 MBD2 WSB1 ENSG00000265246 RPL34P31
GH17F027236 0.7 Ensembl ENCODE 24.8 -57.1 -57076 0.4 CTCF ZNF654 JUNB TRIM22 REST RAD21 ZBTB48 SMC3 ZNF143 WSB1 ENSG00000265246 LOC105371704
GH17F027226 0.5 Ensembl 24.2 -67.4 -67376 0.6 STAT1 JUND ATF3 FOXA3 JUN STAT3 FOS NR3C1 FOSL2 WSB1 LOC105371704 LOC105371703
GH17F027343 1.1 FANTOM5 Ensembl ENCODE 16.2 +51.2 51242 3.8 TBP HDGF HDAC1 PKNOX1 ATF1 NFRKB YY1 CREM SMARCA5 SMAD5 WSB1 LOC100132972 ENSG00000266313
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around WSB1 on UCSC Golden Path with GeneCards custom track

Promoters for WSB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001343051 1424 3401 HDGF PKNOX1 ARNT MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for WSB1 Gene

Chromosome:
17
Start:
27,294,076 bp from pter
End:
27,315,926 bp from pter
Size:
21,851 bases
Orientation:
Plus strand

Genomic View for WSB1 Gene

Genes around WSB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WSB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WSB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WSB1 Gene

Proteins for WSB1 Gene

  • Protein details for WSB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6I7-WSB1_HUMAN
    Recommended name:
    WD repeat and SOCS box-containing protein 1
    Protein Accession:
    Q9Y6I7
    Secondary Accessions:
    • Q9NRB1
    • Q9UBH9
    • Q9UG25
    • Q9UNN6
    • Q9Y656

    Protein attributes for WSB1 Gene

    Size:
    421 amino acids
    Molecular mass:
    47432 Da
    Quaternary structure:
    • Interacts with DIO2. Component of the probable ECS(WSB1) E3 ubiquitin ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and WSB1. Component of a probable ECS-like E3 ubiquitin-protein ligase complex which contains CUL5, RBX1, Elongin BC complex and WSB1. Interacts with CUL5, RNF7, TCEB1 and TCEB2. Binds to HIPK2 through WD40 repeats.

    Alternative splice isoforms for WSB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WSB1 Gene

Post-translational modifications for WSB1 Gene

  • Ubiquitination at Lys 208
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for WSB1 Gene

Domains & Families for WSB1 Gene

Gene Families for WSB1 Gene

Suggested Antigen Peptide Sequences for WSB1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y6I7

UniProtKB/Swiss-Prot:

WSB1_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Contains 6 WD repeats.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Contains 1 SOCS box domain.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with WSB1: view

Function for WSB1 Gene

Molecular function for WSB1 Gene

UniProtKB/Swiss-Prot Function:
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation.

Gene Ontology (GO) - Molecular Function for WSB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 18093972
genes like me logo Genes that share ontologies with WSB1: view
genes like me logo Genes that share phenotypes with WSB1: view

Animal Model Products

miRNA for WSB1 Gene

miRTarBase miRNAs that target WSB1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WSB1 Gene

Localization for WSB1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WSB1 Gene COMPARTMENTS Subcellular localization image for WSB1 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for WSB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with WSB1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WSB1 Gene

Pathways & Interactions for WSB1 Gene

genes like me logo Genes that share pathways with WSB1: view

UniProtKB/Swiss-Prot Q9Y6I7-WSB1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for WSB1 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for WSB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0008150 biological_process ND --
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with WSB1: view

Transcripts for WSB1 Gene

Unigene Clusters for WSB1 Gene

WD repeat and SOCS box containing 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WSB1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - - - - - - -
SP3: -
SP4: - - - - -
SP5: -
SP6: - -
SP7: -
SP8:
SP9: - - - -
SP10: - - - - - - - - - - - -
SP11: - - - - - - - - -
SP12:
SP13: - - - -
SP14: - - - - - -
SP15: - - - - - - - - - - - - - -
SP16: - - - - - - -
SP17: - -

ExUns: 8e ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: - - -
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for WSB1 Gene

GeneLoc Exon Structure for
WSB1
ECgene alternative splicing isoforms for
WSB1

Expression for WSB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WSB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WSB1 Gene



NURSA nuclear receptor signaling pathways regulating expression of WSB1 Gene:

WSB1

SOURCE GeneReport for Unigene cluster for WSB1 Gene:

Hs.446017
genes like me logo Genes that share expression patterns with WSB1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for WSB1 Gene

Orthologs for WSB1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WSB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WSB1 34 35
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia WSB1 34 35
  • 95.57 (n)
cow
(Bos Taurus)
Mammalia WSB1 34 35
  • 94.93 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 92 (a)
OneToMany
-- 35
  • 83 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Wsb1 34
  • 90.34 (n)
mouse
(Mus musculus)
Mammalia Wsb1 34 16 35
  • 90.32 (n)
oppossum
(Monodelphis domestica)
Mammalia WSB1 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves SWIP-1 35
  • 88 (a)
OneToOne
WSB1 34
  • 81.95 (n)
lizard
(Anolis carolinensis)
Reptilia WSB1 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wsb1 34
  • 77.86 (n)
MGC75613 34
African clawed frog
(Xenopus laevis)
Amphibia wsb1-pending-prov 34
zebrafish
(Danio rerio)
Actinopterygii wsb1 34 35
  • 68.73 (n)
wufb92g11 34
fruit fly
(Drosophila melanogaster)
Insecta can 35
  • 7 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea taf-5 35
  • 11 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF5 35
  • 10 (a)
OneToMany
SKI8 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToMany
Species where no ortholog for WSB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WSB1 Gene

ENSEMBL:
Gene Tree for WSB1 (if available)
TreeFam:
Gene Tree for WSB1 (if available)

Paralogs for WSB1 Gene

Variants for WSB1 Gene

Sequence variations from dbSNP and Humsavar for WSB1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10558761 -- 27,302,499(+) AAGTG(-/TA)TATAT intron-variant
rs1060618 -- 27,313,055(+) AAAAA(A/G)TTGTG nc-transcript-variant, utr-variant-3-prime
rs10660665 -- 27,304,544(+) AAAAA(-/A)GGCCA intron-variant
rs11080131 -- 27,309,928(+) TCATC(G/T)CTACT intron-variant
rs111285044 -- 27,303,085(+) GCACC(A/G)GTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WSB1 Gene

Variant ID Type Subtype PubMed ID
dgv540e199 CNV deletion 23128226
dgv902e212 CNV loss 25503493

Variation tolerance for WSB1 Gene

Residual Variation Intolerance Score: 19.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.49; 91.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WSB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WSB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WSB1 Gene

Disorders for WSB1 Gene

Relevant External Links for WSB1

Genetic Association Database (GAD)
WSB1
Human Genome Epidemiology (HuGE) Navigator
WSB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WSB1

No disorders were found for WSB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WSB1 Gene

Publications for WSB1 Gene

  1. SWiP-1: novel SOCS box containing WD-protein regulated by signalling centres and by Shh during development. (PMID: 10354473) Vasiliauskas D. … Stern C.D. (Mech. Dev. 1999) 2 3 4 64
  2. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira A.R. … Marazita M.L. (Genet. Med. 2008) 3 46 64
  3. Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1. (PMID: 18093972) Choi D.W. … Choi C.Y. (J. Biol. Chem. 2008) 3 4 64
  4. The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate. (PMID: 15965468) Dentice M. … Bianco A.C. (Nat. Cell Biol. 2005) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for WSB1 Gene

Sources for WSB1 Gene

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