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Aliases for WRNIP1 Gene

Aliases for WRNIP1 Gene

  • Werner Helicase Interacting Protein 1 2 3 5
  • Werner Helicase-Interacting Protein 1 3 4
  • WHIP 3 4
  • Putative Helicase RUVBL 3
  • EC 3.6.1.3 4
  • BA420G6.2 3
  • EC 3.6.1 63

External Ids for WRNIP1 Gene

Previous GeneCards Identifiers for WRNIP1 Gene

  • GC06P002755
  • GC06P002710

Summaries for WRNIP1 Gene

Entrez Gene Summary for WRNIP1 Gene

  • Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for WRNIP1 Gene

WRNIP1 (Werner Helicase Interacting Protein 1) is a Protein Coding gene. Diseases associated with WRNIP1 include brain compression and posterior myocardial infarction. GO annotations related to this gene include identical protein binding and four-way junction helicase activity.

UniProtKB/Swiss-Prot for WRNIP1 Gene

  • Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis.

Gene Wiki entry for WRNIP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WRNIP1 Gene

Genomics for WRNIP1 Gene

Regulatory Elements for WRNIP1 Gene

Enhancers for WRNIP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WRNIP1 on UCSC Golden Path with GeneCards custom track

Promoters for WRNIP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WRNIP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for WRNIP1 Gene

Chromosome:
6
Start:
2,765,341 bp from pter
End:
2,786,952 bp from pter
Size:
21,612 bases
Orientation:
Plus strand

Genomic View for WRNIP1 Gene

Genes around WRNIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WRNIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WRNIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WRNIP1 Gene

Proteins for WRNIP1 Gene

  • Protein details for WRNIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S55-WRIP1_HUMAN
    Recommended name:
    ATPase WRNIP1
    Protein Accession:
    Q96S55
    Secondary Accessions:
    • B2RDB0
    • Q53EP6
    • Q59ET8
    • Q5W0E2
    • Q5W0E4
    • Q8WV26
    • Q9H681
    • Q9NRJ6

    Protein attributes for WRNIP1 Gene

    Size:
    665 amino acids
    Molecular mass:
    72133 Da
    Quaternary structure:
    • Homooligomer; most likely an octamer. Interacts with POLD1, POLD2 and POLD4. Interacts with the N-terminal domain of WRN. Interacts (via UBZ-type zinc finger) with polyubiquitin.
    SequenceCaution:
    • Sequence=AAF80563.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15383.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for WRNIP1 Gene

    Alternative splice isoforms for WRNIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WRNIP1 Gene

Proteomics data for WRNIP1 Gene at MOPED

Selected DME Specific Peptides for WRNIP1 Gene

Post-translational modifications for WRNIP1 Gene

  • Sumoylated with SUMO1 and SUMO2/3.
  • Ubiquitination at Lys 81, Lys 141, Lys 225, Lys 286, Lys 301, Lys 310, Lys 316, Lys 322, Lys 335, Lys 482, Lys 508, Lys 601, Lys 627, Lys 636, and Lys 661
  • Modification sites at PhosphoSitePlus

Other Protein References for WRNIP1 Gene

Domains & Families for WRNIP1 Gene

Gene Families for WRNIP1 Gene

Suggested Antigen Peptide Sequences for WRNIP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96S55

UniProtKB/Swiss-Prot:

WRIP1_HUMAN :
  • Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
  • Contains 1 UBZ-type zinc finger.
Family:
  • Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
Similarity:
  • Contains 1 UBZ-type zinc finger.
genes like me logo Genes that share domains with WRNIP1: view

Function for WRNIP1 Gene

Molecular function for WRNIP1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis.

Enzyme Numbers (IUBMB) for WRNIP1 Gene

Gene Ontology (GO) - Molecular Function for WRNIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 15670210
GO:0042802 identical protein binding IPI 15670210
genes like me logo Genes that share ontologies with WRNIP1: view
genes like me logo Genes that share phenotypes with WRNIP1: view

Animal Model Products

CRISPR Products

miRNA for WRNIP1 Gene

miRTarBase miRNAs that target WRNIP1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WRNIP1 Gene

Localization for WRNIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WRNIP1 Gene

Nucleus. Note=Colocalizes with WRN in granular structures in the nucleus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WRNIP1 Gene COMPARTMENTS Subcellular localization image for WRNIP1 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for WRNIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0048471 perinuclear region of cytoplasm IDA 17888034
genes like me logo Genes that share ontologies with WRNIP1: view

Pathways & Interactions for WRNIP1 Gene

SuperPathways for WRNIP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WRNIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
genes like me logo Genes that share ontologies with WRNIP1: view

No data available for Pathways by source and SIGNOR curated interactions for WRNIP1 Gene

Drugs & Compounds for WRNIP1 Gene

No Compound Related Data Available

Transcripts for WRNIP1 Gene

Unigene Clusters for WRNIP1 Gene

Werner helicase interacting protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WRNIP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - - -
SP2: - - - -
SP3: -
SP4: -
SP5: -
SP6: - - - - - -

Relevant External Links for WRNIP1 Gene

GeneLoc Exon Structure for
WRNIP1
ECgene alternative splicing isoforms for
WRNIP1

Expression for WRNIP1 Gene

mRNA expression in normal human tissues for WRNIP1 Gene

Protein differential expression in normal tissues from HIPED for WRNIP1 Gene

This gene is overexpressed in Lymph node (11.1), Peripheral blood mononuclear cells (8.0), and Placenta (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WRNIP1 Gene



SOURCE GeneReport for Unigene cluster for WRNIP1 Gene Hs.236828

mRNA Expression by UniProt/SwissProt for WRNIP1 Gene

Q96S55-WRIP1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with WRNIP1: view

Protein tissue co-expression partners for WRNIP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for WRNIP1 Gene

Orthologs for WRNIP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WRNIP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WRNIP1 35
  • 82.55 (n)
  • 86.52 (a)
WRNIP1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WRNIP1 35
  • 91.61 (n)
  • 97.53 (a)
WRNIP1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wrnip1 35
  • 89.19 (n)
  • 95.45 (a)
Wrnip1 16
Wrnip1 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WRNIP1 35
  • 99 (n)
  • 99.55 (a)
WRNIP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wrnip1 35
  • 87.83 (n)
  • 95.15 (a)
oppossum
(Monodelphis domestica)
Mammalia WRNIP1 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WRNIP1 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves WRNIP1 35
  • 74.03 (n)
  • 78.99 (a)
WRNIP1 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WRNIP1 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10820 35
wrnip1 35
  • 66.74 (n)
  • 74.26 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.16690 35
wrnip1 35
  • 68.13 (n)
  • 75.29 (a)
wrnip1 36
  • 61 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL183W 35
  • 53.17 (n)
  • 49.14 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D19360g 35
  • 50.6 (n)
  • 49.88 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MGS1 35
  • 51.12 (n)
  • 49.04 (a)
MGS1 36
  • 36 (a)
OneToOne
MGS1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G24290 35
  • 55.42 (n)
  • 54.03 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08706 35
  • 52.97 (n)
  • 51.1 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC26H5.02c 35
  • 52.92 (n)
  • 51.5 (a)
Species with no ortholog for WRNIP1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WRNIP1 Gene

ENSEMBL:
Gene Tree for WRNIP1 (if available)
TreeFam:
Gene Tree for WRNIP1 (if available)

Paralogs for WRNIP1 Gene

No data available for Paralogs for WRNIP1 Gene

Variants for WRNIP1 Gene

Sequence variations from dbSNP and Humsavar for WRNIP1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1059630 -- 2,785,402(+) TGCCA(G/T)AAATT utr-variant-3-prime
rs5873840 -- 2,777,107(+) TGCTG(-/G/T)GAAAT intron-variant
rs9503298 -- 2,783,679(+) GTAGC(A/G)GGAAG intron-variant
rs6922870 -- 2,772,676(+) TCTAA(C/G)AAGAA intron-variant
rs6923119 -- 2,780,959(+) gcttt(A/C)tggag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WRNIP1 Gene

Variant ID Type Subtype PubMed ID
nsv883389 CNV Gain 21882294
nsv883393 CNV Gain 21882294
nsv883395 CNV Gain 21882294
esv273277 CNV Insertion 20981092
esv271458 CNV Insertion 20981092
esv1193325 CNV Insertion 17803354

Variation tolerance for WRNIP1 Gene

Residual Variation Intolerance Score: 61.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.64; 56.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WRNIP1 Gene

HapMap Linkage Disequilibrium report
WRNIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WRNIP1 Gene

Disorders for WRNIP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for WRNIP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
brain compression
  • compression of brain
posterior myocardial infarction
  • posterior myocardial infarction nos
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for WRNIP1

Genetic Association Database (GAD)
WRNIP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WRNIP1
genes like me logo Genes that share disorders with WRNIP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WRNIP1 Gene

Publications for WRNIP1 Gene

  1. A novel protein interacts with the Werner's syndrome gene product physically and functionally. (PMID: 11301316) Kawabe Y. … Enomoto T. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. Physical and functional interaction between WRNIP1 and RAD18. (PMID: 19556710) Yoshimura A. … Enomoto T. (Genes Genet. Syst. 2009) 3 23
  3. Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner. (PMID: 18842586) Crosetto N. … Dikic I. (J. Biol. Chem. 2008) 3 23
  4. Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer. (PMID: 17888034) Mano Y. … Daigo Y. (Cancer Sci. 2007) 3 23
  5. Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta. (PMID: 15670210) Tsurimoto T. … Enomoto T. (Genes Cells 2005) 3 23

Products for WRNIP1 Gene

Sources for WRNIP1 Gene

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