Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WRN Gene

Aliases for WRN Gene

  • Werner Syndrome, RecQ Helicase-Like 2 3
  • DNA Helicase, RecQ-Like Type 3 3 4
  • RecQ Protein-Like 2 3 4
  • Exonuclease WRN 3 4
  • RECQL2 3 4
  • RECQ3 3 4
  • Werner Syndrome 2
  • EC 3.6.4.12 4
  • EC 3.1.-.- 4
  • EC 3.6.1 63
  • RECQL3 3

External Ids for WRN Gene

Previous GeneCards Identifiers for WRN Gene

  • GC08P030795
  • GC08P031342
  • GC08P030948
  • GC08P029435

Summaries for WRN Gene

Entrez Gene Summary for WRN Gene

  • This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008]

GeneCards Summary for WRN Gene

WRN (Werner Syndrome, RecQ Helicase-Like) is a Protein Coding gene. Diseases associated with WRN include werner syndrome and rapadilino syndrome. Among its related pathways are Integrated Pancreatic Cancer Pathway and Transport to the Golgi and subsequent modification. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is BLM.

UniProtKB/Swiss-Prot for WRN Gene

  • Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3->5 exonuclease activity towards double-stranded DNA with a 5-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation.

Gene Wiki entry for WRN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WRN Gene

Genomics for WRN Gene

Regulatory Elements for WRN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WRN Gene

Chromosome:
8
Start:
31,033,262 bp from pter
End:
31,173,769 bp from pter
Size:
140,508 bases
Orientation:
Plus strand

Genomic View for WRN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WRN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WRN Gene

Proteins for WRN Gene

  • Protein details for WRN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14191-WRN_HUMAN
    Recommended name:
    Werner syndrome ATP-dependent helicase
    Protein Accession:
    Q14191
    Secondary Accessions:
    • A1KYY9

    Protein attributes for WRN Gene

    Size:
    1432 amino acids
    Molecular mass:
    162461 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 magnesium ions per subunit. Has high activity with manganese and zinc ions (in vitro).;
    Quaternary structure:
    • Monomer, and homooligomer. May exist as homodimer, homotrimer, homotetramer and/or homohexamer. Homotetramer, or homohexamer, when bound to DNA. Interacts via its N-terminal domain with WRNIP1 (By similarity). Interacts with EXO1, PCNA and SUPV3L1. Interacts with PML (isoform PML-4).

    Three dimensional structures from OCA and Proteopedia for WRN Gene

neXtProt entry for WRN Gene

Proteomics data for WRN Gene at MOPED

Selected DME Specific Peptides for WRN Gene

Post-translational modifications for WRN Gene

Other Protein References for WRN Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for WRN (WRN)

Domains & Families for WRN Gene

Gene Families for WRN Gene

Suggested Antigen Peptide Sequences for WRN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14191

UniProtKB/Swiss-Prot:

WRN_HUMAN :
  • Contains 1 3-5 exonuclease domain.
  • Belongs to the helicase family. RecQ subfamily.
Domain:
  • Contains 1 3-5 exonuclease domain.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Contains 1 HRDC domain.
Family:
  • Belongs to the helicase family. RecQ subfamily.
genes like me logo Genes that share domains with WRN: view

Function for WRN Gene

Molecular function for WRN Gene

GENATLAS Biochemistry:
DNA helicase(? 3->5 or 5>3) DNA containing exonuclease activity,ATP dependent, containing two transcription initiation sites,homologous to yeast Sgs1,E coli RecQ,C elegans F18C5.2 and X laevis focus forming activity 1 (FFA1),involved in DNA unwinding function,in RNA polymerase II activation in DNA repair replication foci formation,maintaining genomic integrity,stimulated by replication proteins RPA1,RPA2,RPA3,upregulated at the G2/M stage of the cell cycle,predominantly localized in the nucleoplasm,RecQl family
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3->5 exonuclease activity towards double-stranded DNA with a 5-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation.

Enzyme Numbers (IUBMB) for WRN Gene

Gene Ontology (GO) - Molecular Function for WRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0000287 magnesium ion binding IDA 16622405
GO:0000403 Y-form DNA binding IDA 17715146
GO:0000405 bubble DNA binding IDA 11433031
GO:0003676 nucleic acid binding --
genes like me logo Genes that share ontologies with WRN: view
genes like me logo Genes that share phenotypes with WRN: view

Animal Models for WRN Gene

MGI Knock Outs for WRN:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WRN

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for WRN Gene

Localization for WRN Gene

Subcellular locations from UniProtKB/Swiss-Prot for WRN Gene

Nucleus, nucleolus. Nucleus. Nucleus, nucleoplasm. Note=Gamma-irradiation leads to its translocation from nucleoli to nucleoplasm and PML regulates the irradiation-induced WRN relocation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WRN Gene COMPARTMENTS Subcellular localization image for WRN gene
Compartment Confidence
cytoskeleton 5
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for WRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 9618508
GO:0005813 centrosome IDA 17498979
genes like me logo Genes that share ontologies with WRN: view

Pathways & Interactions for WRN Gene

genes like me logo Genes that share pathways with WRN: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • DNA Damage Signaling Pathway in human,mouse,rat
    • Stem Cell Transcription Factors in human,mouse,rat

SIGNOR curated interactions for WRN Gene

Is activated by:

Gene Ontology (GO) - Biological Process for WRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000723 telomere maintenance IMP 18212065
GO:0000724 double-strand break repair via homologous recombination TAS --
GO:0000731 DNA synthesis involved in DNA repair IDA 17563354
GO:0001302 replicative cell aging IEA --
GO:0006139 nucleobase-containing compound metabolic process --
genes like me logo Genes that share ontologies with WRN: view

Drugs & Compounds for WRN Gene

(11) Drugs for WRN Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Bleomycin Approved Pharma 142
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Hydroxyurea Approved Pharma 181
Irinotecan Approved, Investigational Pharma Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 1013

(11) Additional Compounds for WRN Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
4nqo
8-Hydroxyadenine
  • 6-Amino-1,7-dihydro-8H-Purin-8-one
  • 6-Amino-8-hydroxypurine
  • 6-Amino-Purin-8(9H)-one
  • 6-Amino-Purin-8-ol
  • 7,8-Dihydro-8-oxoadenine
21149-26-8
genes like me logo Genes that share compounds with WRN: view

Transcripts for WRN Gene

Unigene Clusters for WRN Gene

Werner syndrome, RecQ helicase-like:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WRN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WRN Gene

No ASD Table

Relevant External Links for WRN Gene

GeneLoc Exon Structure for
WRN
ECgene alternative splicing isoforms for
WRN

Expression for WRN Gene

mRNA expression in normal human tissues for WRN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WRN Gene

This gene is overexpressed in Adrenal (24.3), Pancreatic juice (22.3), Platelet (7.3), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WRN Gene



SOURCE GeneReport for Unigene cluster for WRN Gene Hs.632050

genes like me logo Genes that share expression patterns with WRN: view

Protein tissue co-expression partners for WRN Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WRN Gene

Orthologs for WRN Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WRN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WRN 35
  • 83.64 (n)
  • 74.71 (a)
WRN 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WRN 35
  • 84.58 (n)
  • 76.59 (a)
WRN 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wrn 35
  • 79.48 (n)
  • 71.74 (a)
Wrn 16
Wrn 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WRN 35
  • 99.28 (n)
  • 98.53 (a)
WRN 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1564788 35
  • 77.91 (n)
  • 70.98 (a)
oppossum
(Monodelphis domestica)
Mammalia WRN 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WRN 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves WRN 35
  • 64.04 (n)
  • 56.59 (a)
WRN 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WRN 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wrn 35
  • 61.47 (n)
  • 55.84 (a)
African clawed frog
(Xenopus laevis)
Amphibia FFA-1 35
zebrafish
(Danio rerio)
Actinopterygii wrn 35
  • 57.26 (n)
  • 52.3 (a)
wrn 36
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea wrn-1 37
  • 36 (a)
wrn-1 35
  • 45.87 (n)
  • 34.78 (a)
wrn-1 36
  • 27 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGS1 36
  • 17 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os07g0681600 35
  • 46.54 (n)
  • 36.18 (a)
Species with no ortholog for WRN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WRN Gene

ENSEMBL:
Gene Tree for WRN (if available)
TreeFam:
Gene Tree for WRN (if available)

Paralogs for WRN Gene

Paralogs for WRN Gene

(1) SIMAP similar genes for WRN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WRN: view

Variants for WRN Gene

Sequence variations from dbSNP and Humsavar for WRN Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1012483 -- 31,077,757(+) atata(A/G)agaca intron-variant
rs1012484 -- 31,077,858(+) caaag(A/G)gaagt intron-variant
rs1012485 -- 31,077,862(+) gagaa(G/T)tttgg intron-variant
rs1425295 -- 31,108,447(+) GGAAG(C/T)TTATC intron-variant
rs1425296 -- 31,114,472(+) TCTTT(C/T)GATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WRN Gene

Variant ID Type Subtype PubMed ID
nsv890705 CNV Gain 21882294
nsv890706 CNV Loss 21882294
nsv831278 CNV Gain 17160897

Variation tolerance for WRN Gene

Residual Variation Intolerance Score: 87.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.23; 84.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WRN Gene

HapMap Linkage Disequilibrium report
WRN
Human Gene Mutation Database (HGMD)
WRN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WRN Gene

Disorders for WRN Gene

MalaCards: The human disease database

(16) MalaCards diseases for WRN Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
werner syndrome
  • adult premature ageing syndrome
rapadilino syndrome
  • absent thumbs, dislocated joints, long face with narrow palpebral fissures, long slender nose, arched palate
atypical werner syndrome
  • atypical progeroid syndrome
bloom syndrome
  • bloom-torre-machacek syndrome
jejunal neoplasm
  • neoplasm of jejunum
- elite association
Search WRN in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

WRN_HUMAN
  • Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note=The disease may be caused by mutations affecting the gene represented in this entry.
  • Werner syndrome (WRN) [MIM:277700]: A rare autosomal recessive progeroid syndrome characterized by the premature onset of multiple age-related disorders, including atherosclerosis, cancer, non-insulin-dependent diabetes mellitus, ocular cataracts and osteoporosis. The major cause of death, at a median age of 47, is myocardial infarction. {ECO:0000269 PubMed:16673358}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for WRN Gene

Werner syndrome of premature ageing,with presenile subcapsular posterior cataract,associated with an increased risk of cancer and a chromosome instability

Relevant External Links for WRN

Genetic Association Database (GAD)
WRN
Human Genome Epidemiology (HuGE) Navigator
WRN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WRN
genes like me logo Genes that share disorders with WRN: view

Publications for WRN Gene

  1. Roles of Werner syndrome protein in protection of genome integrity. (PMID: 20075015) Rossi M.L. … Bohr V.A. (DNA Repair (Amst.) 2010) 23 67
  2. Expression profiling of mouse embryonic fibroblasts with a deletion in the helicase domain of the Werner Syndrome gene homologue treated with hydrogen peroxide. (PMID: 20175907) LabbAc A. … Lebel M. (BMC Genomics 2010) 23 67
  3. Werner's syndrome helicase participates in transcription of phenobarbital-inducible CYP2B genes in rat and mouse liver. (PMID: 19737542) Lachaud A.A. … Anderson A. (Biochem. Pharmacol. 2010) 23 67
  4. Depletion of WRN protein causes RACK1 to activate several protein kinase C isoforms. (PMID: 19966859) Massip L. … Lebel M. (Oncogene 2010) 23 67
  5. Acetylation of WRN protein regulates its stability by inhibiting ubiquitination. (PMID: 20428248) Li K. … Luo J. (PLoS ONE 2010) 23 67

Products for WRN Gene

Sources for WRN Gene

Back to Top

Content