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Aliases for WRN Gene

Aliases for WRN Gene

  • Werner Syndrome, RecQ Helicase-Like 2 3
  • RECQL2 3 4 6
  • DNA Helicase, RecQ-Like Type 3 3 4
  • RecQ Protein-Like 2 3 4
  • Exonuclease WRN 3 4
  • RECQ3 3 4
  • Werner Syndrome ATP-Dependent Helicase 3
  • Werner Syndrome 2
  • EC 3.6.4.12 4
  • EC 3.1.-.- 4
  • EC 3.6.1 64
  • RECQL3 3
  • RECQ3, 6

External Ids for WRN Gene

Summaries for WRN Gene

Entrez Gene Summary for WRN Gene

  • This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008]

GeneCards Summary for WRN Gene

WRN (Werner Syndrome, RecQ Helicase-Like) is a Protein Coding gene. Diseases associated with WRN include werner syndrome and rothmund-thomson syndrome. Among its related pathways are Integrated Pancreatic Cancer Pathway and Non-homologous end-joining. GO annotations related to this gene include protein homodimerization activity and protein complex binding. An important paralog of this gene is BLM.

UniProtKB/Swiss-Prot for WRN Gene

  • Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3->5 exonuclease activity towards double-stranded DNA with a 5-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation.

Gene Wiki entry for WRN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WRN Gene

Genomics for WRN Gene

Genomic Location for WRN Gene

Start:
31,033,262 bp from pter
End:
31,173,769 bp from pter
Size:
140,508 bases
Orientation:
Plus strand

Genomic View for WRN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WRN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WRN Gene

Regulatory Elements for WRN Gene

Proteins for WRN Gene

  • Protein details for WRN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14191-WRN_HUMAN
    Recommended name:
    Werner syndrome ATP-dependent helicase
    Protein Accession:
    Q14191
    Secondary Accessions:
    • A1KYY9

    Protein attributes for WRN Gene

    Size:
    1432 amino acids
    Molecular mass:
    162461 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 magnesium ions per subunit. Has high activity with manganese and zinc ions (in vitro).;
    Quaternary structure:
    • Monomer, and homooligomer. May exist as homodimer, homotrimer, homotetramer and/or homohexamer. Homotetramer, or homohexamer, when bound to DNA. Interacts via its N-terminal domain with WRNIP1 (By similarity). Interacts with EXO1, PCNA and SUPV3L1. Interacts with PML (isoform PML-4).

    Three dimensional structures from OCA and Proteopedia for WRN Gene

neXtProt entry for WRN Gene

Proteomics data for WRN Gene at MOPED

Selected DME Specific Peptides for WRN Gene

Post-translational modifications for WRN Gene

Other Protein References for WRN Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for WRN Gene

UniProtKB/Swiss-Prot:

WRN_HUMAN
Domain:
  • Contains 1 3-5 exonuclease domain.:
    • Q14191
  • Contains 1 helicase ATP-binding domain.:
    • Q14191
  • Contains 1 helicase C-terminal domain.:
    • Q14191
  • Contains 1 HRDC domain.:
    • Q14191
Family:
  • Belongs to the helicase family. RecQ subfamily.:
    • Q14191
genes like me logo Genes that share domains with WRN: view

No data available for Gene Families for WRN Gene

Function for WRN Gene

Molecular function for WRN Gene

GENATLAS Biochemistry: DNA helicase(? 3->5 or 5>3) DNA containing exonuclease activity,ATP dependent, containing two transcription initiation sites,homologous to yeast Sgs1,E coli RecQ,C elegans F18C5.2 and X laevis focus forming activity 1 (FFA1),involved in DNA unwinding function,in RNA polymerase II activation in DNA repair replication foci formation,maintaining genomic integrity,stimulated by replication proteins RPA1,RPA2,RPA3,upregulated at the G2/M stage of the cell cycle,predominantly localized in the nucleoplasm,RecQl family
UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function: Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3->5 exonuclease activity towards double-stranded DNA with a 5-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation.

Enzyme Numbers (IUBMB) for WRN Gene

Gene Ontology (GO) - Molecular Function for WRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0000287 magnesium ion binding IDA 16622405
GO:0000403 Y-form DNA binding IDA 17715146
GO:0000405 bubble DNA binding IDA 11433031
GO:0003676 nucleic acid binding --
genes like me logo Genes that share ontologies with WRN: view
genes like me logo Genes that share phenotypes with WRN: view

Animal Models for WRN Gene

MGI Knock Outs for WRN:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for WRN Gene

Localization for WRN Gene

Subcellular locations from UniProtKB/Swiss-Prot for WRN Gene

Nucleus, nucleolus. Nucleus. Nucleus, nucleoplasm. Note=Gamma-irradiation leads to its translocation from nucleoli to nucleoplasm and PML regulates the irradiation-induced WRN relocation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WRN Gene COMPARTMENTS Subcellular localization image for WRN gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for WRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA 11420665
GO:0005813 centrosome IDA 17498979
genes like me logo Genes that share ontologies with WRN: view

Pathways for WRN Gene

genes like me logo Genes that share pathways with WRN: view

Pathways by source for WRN Gene

2 GeneGo (Thomson Reuters Life Sciences Research) pathways for WRN Gene
1 Cell Signaling Technology pathway for WRN Gene

Gene Ontology (GO) - Biological Process for WRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000723 telomere maintenance IMP 18212065
GO:0000731 DNA synthesis involved in DNA repair IDA 17563354
GO:0001302 replicative cell aging IEA --
GO:0006139 nucleobase-containing compound metabolic process --
GO:0006200 obsolete ATP catabolic process --
genes like me logo Genes that share ontologies with WRN: view

Compounds for WRN Gene

(1) HMDB Compounds for WRN Gene

Compound Synonyms Cas Number PubMed IDs
Magnesium
  • Magnesium
7439-95-4

(17) Novoseek inferred chemical compound relationships for WRN Gene

Compound -log(P) Hits PubMed IDs
camptothecin 60.5 5
methylmethanesulfonate 59.2 9
8-hydroxyadenine 55.8 1
4nqo 55.4 3
hydroxyurea 54.7 11
genes like me logo Genes that share compounds with WRN: view

Transcripts for WRN Gene

Unigene Clusters for WRN Gene

Werner syndrome, RecQ helicase-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WRN Gene

No ASD Table

Relevant External Links for WRN Gene

GeneLoc Exon Structure for
WRN
ECgene alternative splicing isoforms for
WRN

Expression for WRN Gene

mRNA expression in normal human tissues for WRN Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WRN Gene

SOURCE GeneReport for Unigene cluster for WRN Gene Hs.632050

genes like me logo Genes that share expressions with WRN: view

Orthologs for WRN Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WRN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WRN 36
  • 99.28 (n)
  • 98.53 (a)
WRN 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WRN 36
  • 83.64 (n)
  • 74.71 (a)
WRN 37
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WRN 36
  • 84.58 (n)
  • 76.59 (a)
WRN 37
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wrn 36
  • 79.48 (n)
  • 71.74 (a)
Wrn 16
Wrn 37
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WRN 37
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WRN 37
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1564788 36
  • 77.91 (n)
  • 70.98 (a)
chicken
(Gallus gallus)
Aves WRN 36
  • 64.04 (n)
  • 56.59 (a)
WRN 37
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WRN 37
  • 52 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia FFA-1 36
tropical clawed frog
(Silurana tropicalis)
Amphibia wrn 36
  • 61.47 (n)
  • 55.84 (a)
zebrafish
(Danio rerio)
Actinopterygii wrn 36
  • 57.26 (n)
  • 52.3 (a)
wrn 37
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea wrn-1 36
  • 45.87 (n)
  • 34.78 (a)
wrn-1 37
  • 27 (a)
OneToOne
wrn-1 38
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGS1 37
  • 17 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os07g0681600 36
  • 46.54 (n)
  • 36.18 (a)
Species with no ortholog for WRN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WRN Gene

ENSEMBL:
Gene Tree for WRN (if available)
TreeFam:
Gene Tree for WRN (if available)

Paralogs for WRN Gene

Paralogs for WRN Gene

Selected SIMAP similar genes for WRN Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WRN: view

Variants for WRN Gene

Sequence variations from dbSNP and Humsavar for WRN Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1012483 -- 31,077,757(+) atata(A/G)agaca intron-variant
rs1012484 -- 31,077,858(+) caaag(A/G)gaagt intron-variant
rs1012485 -- 31,077,862(+) gagaa(G/T)tttgg intron-variant
rs1318126 -- 31,172,158(+) GTGTG(C/T)GCCTG intron-variant
rs1346044 Likely benign, - 31,167,138(+) CTTCA(C/T)GTGAT missense, reference

Structural Variations from Database of Genomic Variants (DGV) for WRN Gene

Variant ID Type Subtype PubMed ID
nsv890705 CNV Gain 21882294
nsv890706 CNV Loss 21882294
nsv831278 CNV Gain 17160897

Relevant External Links for WRN Gene

HapMap Linkage Disequilibrium report
WRN
Human Gene Mutation Database (HGMD)
WRN
Locus Specific Mutation Databases (LSDB)
WRN

Disorders for WRN Gene

(1) OMIM Diseases for WRN Gene (604611)

UniProtKB/Swiss-Prot

WRN_HUMAN
  • Werner syndrome (WRN) [MIM:277700]: A rare autosomal recessive progeroid syndrome characterized by the premature onset of multiple age-related disorders, including atherosclerosis, cancer, non-insulin-dependent diabetes mellitus, ocular cataracts and osteoporosis. The major cause of death, at a median age of 47, is myocardial infarction. {ECO:0000269 PubMed:16673358}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note=The disease may be caused by mutations affecting the gene represented in this entry.

(24) Novoseek inferred disease relationships for WRN Gene

Disease -log(P) Hits PubMed IDs
werner syndrome 99.1 161
bloom syndrome 93.8 29
rothmund-thomson syndrome 90.5 13
progeria 75.9 4
genetic disorder 65.8 10

Genatlas disease for WRN Gene

Werner syndrome of premature ageing,with presenile subcapsular posterior cataract,associated with an increased risk of cancer and a chromosome instability

Relevant External Links for WRN

GeneTests
WRN
GeneReviews
WRN
Genetic Association Database (GAD)
WRN
Human Genome Epidemiology (HuGE) Navigator
WRN
genes like me logo Genes that share disorders with WRN: view

Publications for WRN Gene

  1. The Werner syndrome protein is a DNA helicase. (PMID: 9288107) Gray M.D. … Loeb L.A. (Nat. Genet. 1997) 2 3 23
  2. Nucleolar localization of the Werner syndrome protein in human cells. (PMID: 9618508) Marciniak R.A. … Guarente L. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4 23
  3. Polymorphisms at the Werner locus: I. Newly identified polymorphisms, ethnic variability of 1367Cys/Arg, and its stability in a population of Finnish centenarians. (PMID: 10069711) Castro E. … Oshima J. (Am. J. Med. Genet. 1999) 3 4 23
  4. The 1396del A mutation and a missense mutation or a rare polymorphism of the WRN gene detected in a French Werner family with a severe phenotype and a case of an unusual vulvar cancer. (PMID: 10206685) Vidal V. … Bignon Y.-J. (Hum. Mutat. 1998) 3 4 23
  5. Polymorphisms at the Werner locus: II. 1074Leu/Phe, 1367Cys/Arg, longevity, and atherosclerosis. (PMID: 11186893) Castro E. … Oshima J. (Am. J. Med. Genet. 2000) 3 23 49

Products for WRN Gene

Sources for WRN Gene

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