Aliases for WRB Gene
External Ids for WRB Gene
This gene encodes a basic nuclear protein of unknown function. The gene is widely expressed in adult and fetal tissues. Since the region proposed to contain the gene(s) for congenital heart disease (CHD) in Down syndrome (DS) patients has been restricted to 21q22.2-22.3, this gene, which maps to 21q22.3, has a potential role in the pathogenesis of Down syndrome congenital heart disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
GeneCards Summary for WRB Gene
UniProtKB/Swiss-Prot for WRB Gene
Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane.