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Aliases for WRB Gene

Aliases for WRB Gene

  • Tryptophan Rich Basic Protein 2 3 5
  • Congenital Heart Disease 5 Protein 3 4
  • CHD5 3 4
  • Tail-Anchored Protein Insertion Receptor WRB 3
  • Tryptophan-Rich Basic Protein 4
  • GET1 3

External Ids for WRB Gene

Previous GeneCards Identifiers for WRB Gene

  • GC21P037326
  • GC21P039673
  • GC21P039672
  • GC21P039674
  • GC21P040752
  • GC21P026220

Summaries for WRB Gene

Entrez Gene Summary for WRB Gene

  • This gene is located in the candidate region for congenital heart disease (CHD) in Down syndrome (DS). It encodes a basic protein that functions as a receptor that promotes insertion of tail-anchored proteins in the endoplasmic reticulum membrane. This gene is located at a maternally-methylated differentially methylated region (DMR); however, its transcription may be biallelic, not imprinted. Alternative splicing results in different transcript variants. A pseudogene has been defined on chromosome 4. [provided by RefSeq, Apr 2017]

GeneCards Summary for WRB Gene

WRB (Tryptophan Rich Basic Protein) is a Protein Coding gene. Diseases associated with WRB include Heart Disease and Down Syndrome.

UniProtKB/Swiss-Prot for WRB Gene

  • Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane.

Additional gene information for WRB Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WRB Gene

Genomics for WRB Gene

GeneHancer (GH) Regulatory Elements for WRB Gene

Promoters and enhancers for WRB Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21I039379 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 599.6 +1.0 968 2 HDGF CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 WRB HMGN1 BRWD1 GC21P039407
GH21I039384 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 613.1 +7.3 7323 4.6 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B WRB HMGN1 SH3BGR BRWD1 GC21P039407
GH21I039346 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 22.3 -30.9 -30865 5.3 HDGF ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF766 ZNF213 HMGN1 LOC105372804 PSMG1 WRB BRWD1 SH3BGR LCA5L GC21P039345
GH21I039369 Enhancer 1.1 Ensembl ENCODE 34.9 -9.2 -9188 1.3 HDGF PKNOX1 ATF1 ARNT TCF12 POLR2B ZNF766 E2F8 FOS ATF7 WRB HMGN1 RNF6P1 LOC105372804
GH21I039311 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 17.1 -66.2 -66197 3.4 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 BRWD1 PIR35926 GC21M039313 BRWD1-AS2 HMGN1 PSMG1 WRB LCA5L BRWD1-AS1 SH3BGR
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WRB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WRB gene promoter:

Genomic Locations for WRB Gene

Genomic Locations for WRB Gene
48,853 bases
Plus strand

Genomic View for WRB Gene

Genes around WRB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WRB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WRB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WRB Gene

Proteins for WRB Gene

  • Protein details for WRB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tail-anchored protein insertion receptor WRB
    Protein Accession:
    Secondary Accessions:
    • A8KAP8
    • A8MQ44
    • D3DSH9
    • O60740

    Protein attributes for WRB Gene

    174 amino acids
    Molecular mass:
    19780 Da
    Quaternary structure:
    • Interacts with ASNA1/TRC40.

    Alternative splice isoforms for WRB Gene


neXtProt entry for WRB Gene

Post-translational modifications for WRB Gene

  • Ubiquitination at posLast=4141 and isoforms=257

No data available for DME Specific Peptides for WRB Gene

Domains & Families for WRB Gene

Gene Families for WRB Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for WRB Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WRB/GET1 family.
  • Belongs to the WRB/GET1 family.
genes like me logo Genes that share domains with WRB: view

Function for WRB Gene

Molecular function for WRB Gene

GENATLAS Biochemistry:
tryptophan-rich basic protein,with two copies in the same region or a gene and a pseudogene,expressed in fibroblast derived from fetal endocardial structures,potential transcriptional factor
UniProtKB/Swiss-Prot Function:
Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane.

Phenotypes From GWAS Catalog for WRB Gene

genes like me logo Genes that share phenotypes with WRB: view

Animal Models for WRB Gene

MGI Knock Outs for WRB:
  • Wrb tm1.1(KOMP)Vlcg

miRNA for WRB Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WRB Gene

Localization for WRB Gene

Subcellular locations from UniProtKB/Swiss-Prot for WRB Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WRB gene
Compartment Confidence
nucleus 4
endoplasmic reticulum 4
plasma membrane 3
cytosol 1

Gene Ontology (GO) - Cellular Components for WRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9544840
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with WRB: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for WRB Gene

Pathways & Interactions for WRB Gene

No Data Available

Gene Ontology (GO) - Biological Process for WRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071816 tail-anchored membrane protein insertion into ER membrane IEA --
genes like me logo Genes that share ontologies with WRB: view

No data available for Pathways by source and SIGNOR curated interactions for WRB Gene

Drugs & Compounds for WRB Gene

(6) Drugs for WRB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for WRB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with WRB: view

Transcripts for WRB Gene

Unigene Clusters for WRB Gene

Tryptophan rich basic protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WRB Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: -
SP6: - - - - - - -
SP8: - - - -
SP9: - -

Relevant External Links for WRB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WRB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WRB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WRB Gene

This gene is overexpressed in Retina (15.5), Frontal cortex (11.1), Fetal Brain (8.1), and Testis (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WRB Gene

Protein tissue co-expression partners for WRB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WRB Gene:


SOURCE GeneReport for Unigene cluster for WRB Gene:


Evidence on tissue expression from TISSUES for WRB Gene

  • Nervous system(4.5)
  • Heart(4.2)
  • Stomach(2.2)
genes like me logo Genes that share expression patterns with WRB: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WRB Gene

Orthologs for WRB Gene

This gene was present in the common ancestor of chordates.

Orthologs for WRB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WRB 33 34
  • 99.62 (n)
(Bos Taurus)
Mammalia WRB 33 34
  • 90.42 (n)
(Mus musculus)
Mammalia Wrb 33 16 34
  • 86.21 (n)
(Canis familiaris)
Mammalia WRB 34
  • 85 (a)
(Rattus norvegicus)
Mammalia Wrb 33
  • 84.1 (n)
(Ornithorhynchus anatinus)
Mammalia WRB 34
  • 79 (a)
(Monodelphis domestica)
Mammalia WRB 34
  • 78 (a)
(Gallus gallus)
Aves WRB 33 34
  • 79.89 (n)
(Anolis carolinensis)
Reptilia WRB 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wrb 33
  • 73.33 (n)
Str.9044 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.11476 33
(Danio rerio)
Actinopterygii wrb 33 34
  • 71.6 (n)
wuft06h05 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1462 33
Species where no ortholog for WRB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WRB Gene

Gene Tree for WRB (if available)
Gene Tree for WRB (if available)

Paralogs for WRB Gene Pseudogenes for WRB Gene

genes like me logo Genes that share paralogs with WRB: view

No data available for Paralogs for WRB Gene

Variants for WRB Gene

Sequence variations from dbSNP and Humsavar for WRB Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1000020061 -- 39,398,267(+) G/A downstream_transcript_variant
rs1000031958 -- 39,386,248(+) A/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000086481 -- 39,380,748(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000184438 -- 39,389,720(+) C/T intron_variant
rs1000411696 -- 39,381,682(+) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WRB Gene

Variant ID Type Subtype PubMed ID
dgv4433n100 CNV gain 25217958
esv3557716 CNV deletion 23714750
nsv1061454 CNV gain 25217958

Variation tolerance for WRB Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WRB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WRB Gene

Disorders for WRB Gene

MalaCards: The human disease database

(3) MalaCards diseases for WRB Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
heart disease
  • congenital heart disease
down syndrome
  • trisomy 21
- elite association - COSMIC cancer census association via MalaCards
Search WRB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WRB

genes like me logo Genes that share disorders with WRB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WRB Gene

Publications for WRB Gene

  1. Identification and characterization of a new human cDNA from chromosome 21q22.3 encoding a basic nuclear protein. (PMID: 9544840) Egeo A … Scartezzini P (Human genetics 1998) 2 3 4 22 58
  2. WRB is the receptor for TRC40/Asna1-mediated insertion of tail-anchored proteins into the ER membrane. (PMID: 21444755) Vilardi F … Dobberstein B (Journal of cell science 2011) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M … Chromosome 21 mapping and sequencing consortium (Nature 2000) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for WRB Gene

Sources for WRB Gene

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