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WRB Gene

protein-coding   GIFtS: 50
GCID: GC21P040752

Tryptophan Rich Basic Protein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
Tryptophan Rich Basic Protein1 2     Tryptophan-Rich Protein, Congenital Heart Disease 5 Protein11
CHD52 3 5     Tail-Anchored Protein Insertion Receptor WRB2
Congenital Heart Disease 5 Protein2 3     Tryptophan-Rich Protein2
Tryptophan-Rich Basic Protein2 3     

External Ids:    HGNC: 127901   Entrez Gene: 74852   Ensembl: ENSG000001820937   OMIM: 6029155   UniProtKB: O002583   

Export aliases for WRB gene to outside databases

Previous GC identifers: GC21P037326 GC21P039673 GC21P039672 GC21P039674 GC21P026220


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WRB Gene:
This gene encodes a basic nuclear protein of unknown function. The gene is widely expressed in adult and fetal
tissues. Since the region proposed to contain the gene(s) for congenital heart disease (CHD) in Down syndrome
(DS) patients has been restricted to 21q22.2-22.3, this gene, which maps to 21q22.3, has a potential role in the
pathogenesis of Down syndrome congenital heart disease. Alternatively spliced transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Apr 2009)

GeneCards Summary for WRB Gene:
WRB (tryptophan rich basic protein) is a protein-coding gene. Diseases associated with WRB include down syndrome, and autoimmune hemolytic anemia.

UniProtKB/Swiss-Prot: WRB_HUMAN, O00258
Function: Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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Regulatory elements:
   Regulatory transcription factor binding sites in the WRB gene promoter:
         AP-2rep   SRF   Pbx1a   GATA-3   SRF (504 AA)   Sox9   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): WRB promoter sequence

   Search Chromatin IP Primers for WRB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WRB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.2   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.2
WRB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WRB gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P040752:   GeneLoc Nature:405,311-319
Start:
40,752,170 bp from pter       26,325,991 bp from centromere
End:
40,800,454 bp from pter 26,343,350 bp from centromere
Size:
48,285 bases 17,360 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: Y12478
genomic clones: P128M19


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: WRB_HUMAN, O00258 (See protein sequence)
Recommended Name: Tail-anchored protein insertion receptor WRB  
Size: 174 amino acids; 19780 Da
Subunit: Interacts with ASNA1/TRC40
Secondary accessions: A8KAP8 A8MQ44 D3DSH9 O60740
Alternative splicing: 2 isoforms:  O00258-1   O00258-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WRB: NX_O00258

Explore proteomics data for WRB at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys41, Lys57
  • Modification sites at PhosphoSitePlus

  • See WRB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001139690.1  NP_004618.2  

    ENSEMBL proteins: 
     ENSP00000327716   ENSP00000381737   ENSP00000409030   ENSP00000370089   ENSP00000370084  
     ENSP00000410228   ENSP00000445363  

    WRB Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for WRB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: O00258

    UniProtKB/Swiss-Prot: WRB_HUMAN, O00258
    Similarity: Belongs to the WRB/GET1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WRB_HUMAN, O00258
    Function: Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane

         Genatlas biochemistry entry for WRB:
    tryptophan-rich basic protein,with two copies in the same region or a gene and a pseudogene,expressed in
    fibroblast derived from fetal endocardial structures,potential transcriptional factor

    Phenotypes:
         2 GenomeRNAi human phenotypes for WRB:
     Increased G1 DNA content  Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WRB
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WRB

    miRNA
    Products:
        
    miRTarBase miRNAs that target WRB:
    hsa-mir-26b-5p (MIRT029907), hsa-mir-155-5p (MIRT020873), hsa-mir-425-5p (MIRT016669), hsa-mir-24-3p (MIRT030620)

    Block miRNA regulation of human, mouse, rat WRB using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate WRB:
    hsa-miR-3163 hsa-miR-182 hsa-miR-4255 hsa-miR-145 hsa-miR-3065-5p hsa-miR-34a*
    SwitchGear 3'UTR luciferase reporter plasmidWRB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for WRB
    Predesigned siRNA for gene silencing in human, mouse, rat WRB

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    GenScript: all cDNA clones in your preferred vector (see all 2): WRB (NM_004627)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WRB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WRB_HUMAN, O00258: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    nucleus4
    plasma membrane3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS9544840
    GO:0005730nucleolus ----
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    WRB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WRB
    Interactions:

        Search GeneGlobe Interaction Network for WRB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WRB (ENSP000003277164) via UniProtKB, MINT, STRING, and/or I2D (see all 94)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASNA1ENSP000003498874STRING: ENSP00000349887
    ATP13A1ENSP000003498774STRING: ENSP00000349877
    COG6ENSP000003974414STRING: ENSP00000397441
    KIAA1432ENSP000004022404STRING: ENSP00000402240
    GOLT1AENSP000003085354STRING: ENSP00000308535
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WRB

    10 Novoseek inferred chemical compound relationships for WRB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylcholine 47.6 1 18234676 (1)
    hocl 46.9 3 14671042 (1), 15807192 (1)
    phosphatidylserine 36.5 1 17765009 (1)
    iodide 35.5 2 7512826 (1), 8718891 (1)
    polyacrylamide 24.9 3 2340286 (1), 8718891 (1)
    lipid 23.4 3 8889194 (1), 18234676 (1), 7512826 (1)
    ozone 23.1 1 9028865 (1)
    methionine 12.8 1 15591095 (1)
    cysteine 12.3 1 12551937 (1)
    tyrosine 0 3 2106517 (1), 10439915 (1), 18208457 (1)



    WRB for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for WRB gene (2 alternative transcripts): 
    NM_001146218.1  NM_004627.4  

    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000333781(uc002yxs.3) ENST00000487869(uc011aep.1) ENST00000471468
    ENST00000398753 ENST00000442773 ENST00000380713 ENST00000380708(uc002yxt.4 uc010goj.3)
    ENST00000466787(uc011aeo.1) ENST00000415847 ENST00000490860 ENST00000478273
    ENST00000476914 ENST00000480690 ENST00000541890
    miRNA
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    Block miRNA regulation of human, mouse, rat WRB using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate WRB:
    hsa-miR-3163 hsa-miR-182 hsa-miR-4255 hsa-miR-145 hsa-miR-3065-5p hsa-miR-34a*
    SwitchGear 3'UTR luciferase reporter plasmidWRB 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for WRB
    Predesigned siRNA for gene silencing in human, mouse, rat WRB
    Clone
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    OriGene ORF clones in mouse, rat for WRB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): WRB (NM_004627)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WRB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WRB
    Primer
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    OriGene qPCR primer pairs and template standards for WRB
    OriGene qSTAR qPCR primer pairs in human, mouse for WRB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WRB
      QuantiTect SYBR Green Assays in human, mouse, rat WRB
      QuantiFast Probe-based Assays in human, mouse, rat WRB

    Selected AceView cDNA sequences (see all 393):

    BU734633 AI934908 BM470417 AV653124 BQ771788 BM128577 BU729884 AI696477 
    AI699511 AA977650 AI795916 AI076545 CB113614 BP372637 BM696577 AA329843 
    CR600902 AI631271 AA708451 BU632300 CB988076 AI583388 F29744 AA627711 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for WRB (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
    SP1:                                                              -     -     -                 -                                             
    SP2:                          -     -     -     -                 -     -     -                 -                                             
    SP3:                                -     -     -                 -     -     -                 -                                             
    SP4:                                                              -     -     -           -     -     -                                       
    SP5:                                                                                            -                                             


    ECgene alternative splicing isoforms for WRB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WRB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCATTGTT
    WRB Expression
    About this image


    WRB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)
             Cerebellum
    WRB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WRB Protein Expression
        Custom PCR Arrays for WRB
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WRB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for WRB gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wrb1 , 5 tryptophan rich basic protein1, 5 86.21(n)1
    93.1(a)1
      16 (56.84 cM)5
    714461  NM_207301.21  NP_997184.11 
     961454075 
    chicken
    (Gallus gallus)
    Aves WRB1 tryptophan rich basic protein 79.89(n)
    86.51(a)
      770415  NM_001079497.1  NP_001072965.1 
    lizard
    (Anolis carolinensis)
    Reptilia WRB6
    tryptophan rich basic protein
    75(a)
    1 ↔ 1
    3(139695040-139704461)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.114762 Xenopus laevis transcribed sequence with moderate similarity more 72.81(n)    CD362029.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wuft06h052 wuft06h05 75.86(n)   335756  BM026383.1 


    ENSEMBL Gene Tree for WRB (if available)
    TreeFam Gene Tree for WRB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WRB gene

    WRB for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for WRB
    PGOHUM00000250729


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WRB (see all 443)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1409554841,2
    --40750318(+) CTCCTG/TCTCTT 1 -- us2k10--------
    rs110884731,2
    C,F,H--40750401(+) ATAGTT/GTTGCT 1 -- us2k115Minor allele frequency- G:0.05NS EA NA WA 2218
    rs28369961,2
    C,F,O,H--40750439(+) GTAGAA/CCCACA 1 -- us2k111Minor allele frequency- C:0.22NA NS EA WA CSA 787
    rs2013556101,2
    C--40750451(+) CCTCT-/TTCTTTTC 1 -- us2k10--------
    rs2017437081,2
    C--40750521(+) CTTTC-/TTTTCT 1 -- us2k10--------
    rs1855969921,2
    --40750551(+) TTTCTG/TTCTTT 1 -- us2k10--------
    rs1905232191,2
    --40750555(+) TTTCTC/TTCTTT 1 -- us2k10--------
    rs1930879851,2
    --40750559(+) TTTCTC/TTCTTT 1 -- us2k10--------
    rs1853508091,2
    C--40750563(+) TTTCTC/G/TTCTTT 1 -- us2k10--------
    rs665197581,2
    C--40750567(-) GAGAC-/AGAAA 
     GAAAGAA
    AGAAA
    1 -- us2k11Minor allele frequency- AGAAAGAAAGAA:0.00NA 2

    HapMap Linkage Disequilibrium report for WRB (40752170 - 40800454 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for WRB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv913744CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WRB
    DNA2.0 Custom Variant and Variant Library Synthesis for WRB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602915    OMIM disorders: --

    6 diseases for WRB:    
    About MalaCards
    down syndrome    autoimmune hemolytic anemia    hemolytic anemia    anxiety disorder
    endotheliitis    cerebritis

    1 disease from the University of Copenhagen DISEASES database for WRB:
    Autoimmune hemolytic anemia

    WRB for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: WRB (1 document)

    Export disorders for WRB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WRB gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with WRB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a new human cDNA from chromosome 21q22.3 encoding a basic nuclear protein. (PubMed id 9544840)1, 2, 3, 9 Egeo A.... Scartezzini P. (Hum. Genet. 1998)
    2. WRB is the receptor for TRC40/Asna1-mediated insertion of tail- anchored proteins into the ER membrane. (PubMed id 21444755)1, 2 Vilardi F.... Dobberstein B. (J. Cell Sci. 2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Molecular machinery for insertion of tail-anchored membrane proteins into the endoplasmic reticulum membrane in mammalian cells. (PubMed id 23041287)1 Yamamoto Y. and Sakisaka T. (Mol. Cell 2012)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Replication of previous genome-wide association studies of bone mineral density in premenopausal American women. (PubMed id 20200978)1 Ichikawa S....Econs M.J. (J. Bone Miner. Res. 2010)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7485 HGNC: 12790 AceView: WRBandSH3BGR Ensembl:ENSG00000182093 euGenes: HUgn7485
    ECgene: WRB H-InvDB: WRB

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WRB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WRB gene:
    Search GeneIP for patents involving WRB

    GeneCards and IP:
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