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Aliases for WRB Gene

Aliases for WRB Gene

  • Tryptophan Rich Basic Protein 2 3
  • CHD5 3 4 6
  • Congenital Heart Disease 5 Protein 3 4
  • Tryptophan-Rich Basic Protein 3 4
  • Tail-Anchored Protein Insertion Receptor WRB 3
  • Tryptophan-Rich Protein 3

External Ids for WRB Gene

Previous GeneCards Identifiers for WRB Gene

  • GC21P037326
  • GC21P039673
  • GC21P039672
  • GC21P039674
  • GC21P040752
  • GC21P026220

Summaries for WRB Gene

Entrez Gene Summary for WRB Gene

  • This gene encodes a basic nuclear protein of unknown function. The gene is widely expressed in adult and fetal tissues. Since the region proposed to contain the gene(s) for congenital heart disease (CHD) in Down syndrome (DS) patients has been restricted to 21q22.2-22.3, this gene, which maps to 21q22.3, has a potential role in the pathogenesis of Down syndrome congenital heart disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

GeneCards Summary for WRB Gene

WRB (Tryptophan Rich Basic Protein) is a Protein Coding gene. Diseases associated with WRB include congenital heart disease and down syndrome.

UniProtKB/Swiss-Prot for WRB Gene

  • Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WRB Gene

Genomics for WRB Gene

Regulatory Elements for WRB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WRB Gene

39,380,244 bp from pter
39,428,528 bp from pter
48,285 bases
Plus strand

Genomic View for WRB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WRB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WRB Gene

Proteins for WRB Gene

  • Protein details for WRB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tail-anchored protein insertion receptor WRB
    Protein Accession:
    Secondary Accessions:
    • A8KAP8
    • A8MQ44
    • D3DSH9
    • O60740

    Protein attributes for WRB Gene

    174 amino acids
    Molecular mass:
    19780 Da
    Quaternary structure:
    • Interacts with ASNA1/TRC40.

    Alternative splice isoforms for WRB Gene


neXtProt entry for WRB Gene

Proteomics data for WRB Gene at MOPED

Post-translational modifications for WRB Gene

  • Ubiquitination at Lys41 and Lys57
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WRB Gene

Domains for WRB Gene

Protein Domains for WRB Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WRB/GET1 family.
  • Belongs to the WRB/GET1 family.
genes like me logo Genes that share domains with WRB: view

No data available for Gene Families for WRB Gene

Function for WRB Gene

Molecular function for WRB Gene

GENATLAS Biochemistry:
tryptophan-rich basic protein,with two copies in the same region or a gene and a pseudogene,expressed in fibroblast derived from fetal endocardial structures,potential transcriptional factor
UniProtKB/Swiss-Prot Function:
Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane.

Phenotypes for WRB Gene

genes like me logo Genes that share phenotypes with WRB: view

Animal Model Products

miRNA for WRB Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for WRB Gene

Localization for WRB Gene

Subcellular locations from UniProtKB/Swiss-Prot for WRB Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for WRB Gene COMPARTMENTS Subcellular localization image for WRB gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for WRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9544840
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with WRB: view

Pathways for WRB Gene

SuperPathways for WRB Gene

No Data Available

Gene Ontology (GO) - Biological Process for WRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071816 tail-anchored membrane protein insertion into ER membrane IEA --
genes like me logo Genes that share ontologies with WRB: view

No data available for Pathways by source for WRB Gene

Drugs for WRB Gene

(10) Novoseek inferred chemical compound relationships for WRB Gene

Compound -log(P) Hits PubMed IDs
phosphatidylcholine 47.6 1
hocl 46.9 2
phosphatidylserine 36.5 1
iodide 35.5 2
polyacrylamide 24.9 2
genes like me logo Genes that share compounds with WRB: view

Transcripts for WRB Gene

Unigene Clusters for WRB Gene

Tryptophan rich basic protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WRB Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: -
SP6: - - - - - - -
SP8: - - - -
SP9: - -

Relevant External Links for WRB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WRB Gene

mRNA expression in normal human tissues for WRB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for WRB Gene

This gene is overexpressed in Retina (15.5), Frontal cortex (11.1), Fetal Brain (8.1), and Testis (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WRB Gene

SOURCE GeneReport for Unigene cluster for WRB Gene Hs.744958

genes like me logo Genes that share expressions with WRB: view

Expression partners for WRB Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WRB Gene

Orthologs for WRB Gene

This gene was present in the common ancestor of chordates.

Orthologs for WRB Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WRB 35
  • 90.42 (n)
  • 95.98 (a)
WRB 36
  • 96 (a)
(Mus musculus)
Mammalia Wrb 35
  • 86.21 (n)
  • 93.1 (a)
Wrb 16
Wrb 36
  • 93 (a)
(Pan troglodytes)
Mammalia WRB 35
  • 99.62 (n)
  • 100 (a)
WRB 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Wrb 35
  • 84.1 (n)
  • 91.95 (a)
(Canis familiaris)
Mammalia WRB 36
  • 85 (a)
(Monodelphis domestica)
Mammalia WRB 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia WRB 36
  • 79 (a)
(Gallus gallus)
Aves WRB 35
  • 79.89 (n)
  • 86.51 (a)
WRB 36
  • 86 (a)
(Anolis carolinensis)
Reptilia WRB 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9044 35
wrb 35
  • 73.33 (n)
  • 78.18 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.11476 35
(Danio rerio)
Actinopterygii wrb 35
  • 71.6 (n)
  • 69.82 (a)
wuft06h05 35
wrb 36
  • 69 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1462 35
Species with no ortholog for WRB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WRB Gene

Gene Tree for WRB (if available)
Gene Tree for WRB (if available)

Paralogs for WRB Gene Pseudogenes for WRB Gene

genes like me logo Genes that share paralogs with WRB: view

No data available for Paralogs for WRB Gene

Variants for WRB Gene

Sequence variations from dbSNP and Humsavar for WRB Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs13230 -- 39,397,364(+) ATACC(A/G)CTACT utr-variant-3-prime
rs1060180 -- 39,397,091(+) TGAGA(G/T)AGTCT utr-variant-3-prime
rs1142269 -- 39,380,475(+) CGTCC(A/T)TCTCA missense, reference, upstream-variant-2KB, utr-variant-5-prime
rs2094874 -- 39,381,081(+) CATCC(C/T)ACCCT intron-variant
rs2244352 -- 39,386,047(+) TCCTC(G/T)CAATC upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WRB Gene

Variant ID Type Subtype PubMed ID
nsv913744 CNV Loss 21882294

Relevant External Links for WRB Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WRB Gene

Disorders for WRB Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for WRB Gene in MalaCards »

(2) Diseases for WRB Gene

(1) University of Copenhagen DISEASES for WRB Gene

Relevant External Links for WRB

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with WRB: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for WRB Gene

Publications for WRB Gene

  1. Identification and characterization of a new human cDNA from chromosome 21q22.3 encoding a basic nuclear protein. (PMID: 9544840) Egeo A. … Scartezzini P. (Hum. Genet. 1998) 2 3 4 23
  2. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. WRB is the receptor for TRC40/Asna1-mediated insertion of tail- anchored proteins into the ER membrane. (PMID: 21444755) Vilardi F. … Dobberstein B. (J. Cell Sci. 2011) 3 4
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for WRB Gene

Sources for WRB Gene

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