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Aliases for WRB Gene

Aliases for WRB Gene

  • Tryptophan Rich Basic Protein 2 3 5
  • Congenital Heart Disease 5 Protein 3 4
  • CHD5 3 4
  • Tryptophan-Rich Basic Protein 4
  • GET1 3

External Ids for WRB Gene

Previous GeneCards Identifiers for WRB Gene

  • GC21P037326
  • GC21P039673
  • GC21P039672
  • GC21P039674
  • GC21P040752
  • GC21P026220

Summaries for WRB Gene

Entrez Gene Summary for WRB Gene

  • This gene encodes a basic nuclear protein of unknown function. The gene is widely expressed in adult and fetal tissues. Since the region proposed to contain the gene(s) for congenital heart disease (CHD) in Down syndrome (DS) patients has been restricted to 21q22.2-22.3, this gene, which maps to 21q22.3, has a potential role in the pathogenesis of Down syndrome congenital heart disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

GeneCards Summary for WRB Gene

WRB (Tryptophan Rich Basic Protein) is a Protein Coding gene. Diseases associated with WRB include Heart Disease and Congenital Heart Disease.

UniProtKB/Swiss-Prot for WRB Gene

  • Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WRB Gene

Genomics for WRB Gene

Regulatory Elements for WRB Gene

Enhancers for WRB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WRB on UCSC Golden Path with GeneCards custom track

Promoters for WRB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WRB on UCSC Golden Path with GeneCards custom track

Genomic Location for WRB Gene

39,379,676 bp from pter
39,428,528 bp from pter
48,853 bases
Plus strand

Genomic View for WRB Gene

Genes around WRB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WRB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WRB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WRB Gene

Proteins for WRB Gene

  • Protein details for WRB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tail-anchored protein insertion receptor WRB
    Protein Accession:
    Secondary Accessions:
    • A8KAP8
    • A8MQ44
    • D3DSH9
    • O60740

    Protein attributes for WRB Gene

    174 amino acids
    Molecular mass:
    19780 Da
    Quaternary structure:
    • Interacts with ASNA1/TRC40.

    Alternative splice isoforms for WRB Gene


neXtProt entry for WRB Gene

Proteomics data for WRB Gene at MOPED

Post-translational modifications for WRB Gene

  • Ubiquitination at Lys 41 and Lys 57
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WRB Gene

Domains & Families for WRB Gene

Protein Domains for WRB Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WRB/GET1 family.
  • Belongs to the WRB/GET1 family.
genes like me logo Genes that share domains with WRB: view

No data available for Gene Families for WRB Gene

Function for WRB Gene

Molecular function for WRB Gene

GENATLAS Biochemistry:
tryptophan-rich basic protein,with two copies in the same region or a gene and a pseudogene,expressed in fibroblast derived from fetal endocardial structures,potential transcriptional factor
UniProtKB/Swiss-Prot Function:
Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane.
genes like me logo Genes that share phenotypes with WRB: view

Animal Models for WRB Gene

MGI Knock Outs for WRB:
  • Wrb tm1.1(KOMP)Vlcg

Animal Model Products

miRNA for WRB Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WRB Gene

Localization for WRB Gene

Subcellular locations from UniProtKB/Swiss-Prot for WRB Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for WRB Gene COMPARTMENTS Subcellular localization image for WRB gene
Compartment Confidence
endoplasmic reticulum 4
nucleus 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for WRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with WRB: view

Pathways & Interactions for WRB Gene

SuperPathways for WRB Gene

No Data Available

Gene Ontology (GO) - Biological Process for WRB Gene


No data available for Pathways by source and SIGNOR curated interactions for WRB Gene

Drugs & Compounds for WRB Gene

(4) Drugs for WRB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for WRB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with WRB: view

Transcripts for WRB Gene

Unigene Clusters for WRB Gene

Tryptophan rich basic protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WRB Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: -
SP6: - - - - - - -
SP8: - - - -
SP9: - -

Relevant External Links for WRB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WRB Gene

mRNA expression in normal human tissues for WRB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WRB Gene

This gene is overexpressed in Retina (15.5), Frontal cortex (11.1), Fetal Brain (8.1), and Testis (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WRB Gene

SOURCE GeneReport for Unigene cluster for WRB Gene Hs.744958

genes like me logo Genes that share expression patterns with WRB: view

Protein tissue co-expression partners for WRB Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WRB Gene

Orthologs for WRB Gene

This gene was present in the common ancestor of chordates.

Orthologs for WRB Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WRB 35
  • 90.42 (n)
  • 95.98 (a)
WRB 36
  • 96 (a)
(Mus musculus)
Mammalia Wrb 35
  • 86.21 (n)
  • 93.1 (a)
Wrb 16
Wrb 36
  • 93 (a)
(Pan troglodytes)
Mammalia WRB 35
  • 99.62 (n)
  • 100 (a)
WRB 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Wrb 35
  • 84.1 (n)
  • 91.95 (a)
(Canis familiaris)
Mammalia WRB 36
  • 85 (a)
(Monodelphis domestica)
Mammalia WRB 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia WRB 36
  • 79 (a)
(Gallus gallus)
Aves WRB 35
  • 79.89 (n)
  • 86.51 (a)
WRB 36
  • 86 (a)
(Anolis carolinensis)
Reptilia WRB 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9044 35
wrb 35
  • 73.33 (n)
  • 78.18 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.11476 35
(Danio rerio)
Actinopterygii wrb 35
  • 71.6 (n)
  • 69.82 (a)
wuft06h05 35
wrb 36
  • 69 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1462 35
Species with no ortholog for WRB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WRB Gene

Gene Tree for WRB (if available)
Gene Tree for WRB (if available)

Paralogs for WRB Gene Pseudogenes for WRB Gene

genes like me logo Genes that share paralogs with WRB: view

No data available for Paralogs for WRB Gene

Variants for WRB Gene

Sequence variations from dbSNP and Humsavar for WRB Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs35946782 - 39,391,828(-) CAATA(C/T)GTAGA reference, missense
rs1142269 -- 39,380,475(+) CGTCC(A/T)TCTCA intron-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs2299739 -- 39,385,961(+) TGCAC(A/G)CACTG intron-variant, upstream-variant-2KB
rs2299740 -- 39,386,105(+) CGGGC(C/T)GAGTG intron-variant, upstream-variant-2KB
rs2299741 -- 39,396,344(+) GACCA(C/T)GGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WRB Gene

Variant ID Type Subtype PubMed ID
nsv913744 CNV Loss 21882294

Variation tolerance for WRB Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for WRB Gene

Disorders for WRB Gene

MalaCards: The human disease database

(3) MalaCards diseases for WRB Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
heart disease
  • congestive heart failure
congenital heart disease
  • congenital anomaly of heart
down syndrome
  • complete trisomy 21 syndrome
- elite association - COSMIC cancer census association via MalaCards
Search WRB in MalaCards View complete list of genes associated with diseases

Relevant External Links for WRB

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with WRB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WRB Gene

Publications for WRB Gene

  1. Identification and characterization of a new human cDNA from chromosome 21q22.3 encoding a basic nuclear protein. (PMID: 9544840) Egeo A. … Scartezzini P. (Hum. Genet. 1998) 2 3 4 23 67
  2. WRB is the receptor for TRC40/Asna1-mediated insertion of tail- anchored proteins into the ER membrane. (PMID: 21444755) Vilardi F. … Dobberstein B. (J. Cell Sci. 2011) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Molecular machinery for insertion of tail-anchored membrane proteins into the endoplasmic reticulum membrane in mammalian cells. (PMID: 23041287) Yamamoto Y. … Sakisaka T. (Mol. Cell 2012) 3
  5. Replication of previous genome-wide association studies of bone mineral density in premenopausal American women. (PMID: 20200978) Ichikawa S. … Econs M.J. (J. Bone Miner. Res. 2010) 3

Products for WRB Gene

Sources for WRB Gene