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Aliases for WRB Gene

Aliases for WRB Gene

  • Tryptophan Rich Basic Protein 2 3 5
  • Congenital Heart Disease 5 Protein 3 4
  • CHD5 3 4
  • Tail-Anchored Protein Insertion Receptor WRB 3
  • Tryptophan-Rich Basic Protein 4
  • GET1 3

External Ids for WRB Gene

Previous GeneCards Identifiers for WRB Gene

  • GC21P037326
  • GC21P039673
  • GC21P039672
  • GC21P039674
  • GC21P040752
  • GC21P026220

Summaries for WRB Gene

Entrez Gene Summary for WRB Gene

  • This gene encodes a basic nuclear protein of unknown function. The gene is widely expressed in adult and fetal tissues. Since the region proposed to contain the gene(s) for congenital heart disease (CHD) in Down syndrome (DS) patients has been restricted to 21q22.2-22.3, this gene, which maps to 21q22.3, has a potential role in the pathogenesis of Down syndrome congenital heart disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

GeneCards Summary for WRB Gene

WRB (Tryptophan Rich Basic Protein) is a Protein Coding gene. Diseases associated with WRB include Heart Disease and Down Syndrome.

UniProtKB/Swiss-Prot for WRB Gene

  • Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WRB Gene

Genomics for WRB Gene

Regulatory Elements for WRB Gene

Enhancers for WRB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21F039384 0.2 ENCODE 63.1 +7.3 7323 4.6 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 HMGN1 WRB SH3BGR BRWD1 GC21P039407
GH21F039379 1.1 FANTOM5 ENCODE 49.6 +1.0 969 2.0 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF548 ZNF263 SP3 SP5 WRB HMGN1 BRWD1 GC21P039407
GH21F039369 1.1 Ensembl ENCODE 34.9 -9.2 -9202 1.3 HDGF PKNOX1 ATF1 ARNT FOS NCOA1 MEF2D SMARCA4 NBN HMBOX1 WRB RNF6P1 LOC105372804
GH21F039346 0.2 ENCODE 22.3 -30.9 -30865 5.3 HDGF ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 PSMG1 BRWD1 WRB HMGN1 SH3BGR LCA5L GC21P039345
GH21F039363 0.2 ENCODE 17.8 -15.9 -15880 0.6 ZNF589 NR4A1 ZNF175 PRDM10 ZNF518A ZBTB20 GABPA WRB LOC105372804 RNF6P1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around WRB on UCSC Golden Path with GeneCards custom track

Promoters for WRB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106888 924 2001 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF548 ZNF263 SP3 SP5

Genomic Location for WRB Gene

Chromosome:
21
Start:
39,379,676 bp from pter
End:
39,428,528 bp from pter
Size:
48,853 bases
Orientation:
Plus strand

Genomic View for WRB Gene

Genes around WRB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WRB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WRB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WRB Gene

Proteins for WRB Gene

  • Protein details for WRB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00258-WRB_HUMAN
    Recommended name:
    Tail-anchored protein insertion receptor WRB
    Protein Accession:
    O00258
    Secondary Accessions:
    • A8KAP8
    • A8MQ44
    • D3DSH9
    • O60740

    Protein attributes for WRB Gene

    Size:
    174 amino acids
    Molecular mass:
    19780 Da
    Quaternary structure:
    • Interacts with ASNA1/TRC40.

    Alternative splice isoforms for WRB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WRB Gene

Post-translational modifications for WRB Gene

  • Ubiquitination at Lys 41 and Lys 57
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WRB Gene

Domains & Families for WRB Gene

Protein Domains for WRB Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O00258

UniProtKB/Swiss-Prot:

WRB_HUMAN :
  • Belongs to the WRB/GET1 family.
Family:
  • Belongs to the WRB/GET1 family.
genes like me logo Genes that share domains with WRB: view

No data available for Gene Families for WRB Gene

Function for WRB Gene

Molecular function for WRB Gene

GENATLAS Biochemistry:
tryptophan-rich basic protein,with two copies in the same region or a gene and a pseudogene,expressed in fibroblast derived from fetal endocardial structures,potential transcriptional factor
UniProtKB/Swiss-Prot Function:
Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane.
genes like me logo Genes that share phenotypes with WRB: view

Animal Models for WRB Gene

MGI Knock Outs for WRB:
  • Wrb tm1.1(KOMP)Vlcg

Animal Model Products

miRNA for WRB Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WRB Gene

Localization for WRB Gene

Subcellular locations from UniProtKB/Swiss-Prot for WRB Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WRB Gene COMPARTMENTS Subcellular localization image for WRB gene
Compartment Confidence
endoplasmic reticulum 4
nucleus 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for WRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9544840
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with WRB: view

Pathways & Interactions for WRB Gene

SuperPathways for WRB Gene

No Data Available

Gene Ontology (GO) - Biological Process for WRB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071816 tail-anchored membrane protein insertion into ER membrane IEA --
genes like me logo Genes that share ontologies with WRB: view

No data available for Pathways by source and SIGNOR curated interactions for WRB Gene

Drugs & Compounds for WRB Gene

(4) Drugs for WRB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for WRB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with WRB: view

Transcripts for WRB Gene

Unigene Clusters for WRB Gene

Tryptophan rich basic protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WRB Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: -
SP6: - - - - - - -
SP7:
SP8: - - - -
SP9: - -

Relevant External Links for WRB Gene

GeneLoc Exon Structure for
WRB
ECgene alternative splicing isoforms for
WRB

Expression for WRB Gene

mRNA expression in normal human tissues for WRB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WRB Gene

This gene is overexpressed in Retina (15.5), Frontal cortex (11.1), Fetal Brain (8.1), and Testis (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WRB Gene



Protein tissue co-expression partners for WRB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WRB Gene:

WRB

SOURCE GeneReport for Unigene cluster for WRB Gene:

Hs.744958
genes like me logo Genes that share expression patterns with WRB: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WRB Gene

Orthologs for WRB Gene

This gene was present in the common ancestor of chordates.

Orthologs for WRB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WRB 34 35
  • 99.62 (n)
cow
(Bos Taurus)
Mammalia WRB 34 35
  • 90.42 (n)
mouse
(Mus musculus)
Mammalia Wrb 34 16 35
  • 86.21 (n)
dog
(Canis familiaris)
Mammalia WRB 35
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wrb 34
  • 84.1 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WRB 35
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WRB 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves WRB 34 35
  • 79.89 (n)
lizard
(Anolis carolinensis)
Reptilia WRB 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wrb 34
  • 73.33 (n)
Str.9044 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.11476 34
zebrafish
(Danio rerio)
Actinopterygii wrb 34 35
  • 71.6 (n)
wuft06h05 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1462 34
Species where no ortholog for WRB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WRB Gene

ENSEMBL:
Gene Tree for WRB (if available)
TreeFam:
Gene Tree for WRB (if available)

Paralogs for WRB Gene

Pseudogenes.org Pseudogenes for WRB Gene

genes like me logo Genes that share paralogs with WRB: view

No data available for Paralogs for WRB Gene

Variants for WRB Gene

Sequence variations from dbSNP and Humsavar for WRB Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1060180 -- 39,397,091(+) TGAGA(G/T)AGTCT intron-variant, utr-variant-3-prime
rs10775662 -- 39,384,749(+) AAATA(A/G)AAAAA intron-variant
rs11088473 -- 39,378,475(+) ATAGT(G/T)TTGCT nc-transcript-variant, upstream-variant-2KB
rs111226667 -- 39,389,666(+) CTCCT(G/T)TGTCA intron-variant
rs111394087 -- 39,390,579(+) AGGGA(C/T)GCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WRB Gene

Variant ID Type Subtype PubMed ID
dgv4433n100 CNV gain 25217958
esv3557716 CNV deletion 23714750
nsv1061454 CNV gain 25217958

Variation tolerance for WRB Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WRB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WRB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WRB Gene

Disorders for WRB Gene

MalaCards: The human disease database

(3) MalaCards diseases for WRB Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
heart disease
  • congenital heart disease
down syndrome
  • complete trisomy 21 syndrome
pylorospasm
- elite association - COSMIC cancer census association via MalaCards
Search WRB in MalaCards View complete list of genes associated with diseases

Relevant External Links for WRB

Human Genome Epidemiology (HuGE) Navigator
WRB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WRB
genes like me logo Genes that share disorders with WRB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WRB Gene

Publications for WRB Gene

  1. Identification and characterization of a new human cDNA from chromosome 21q22.3 encoding a basic nuclear protein. (PMID: 9544840) Egeo A. … Scartezzini P. (Hum. Genet. 1998) 2 3 4 22 64
  2. WRB is the receptor for TRC40/Asna1-mediated insertion of tail- anchored proteins into the ER membrane. (PMID: 21444755) Vilardi F. … Dobberstein B. (J. Cell Sci. 2011) 2 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4 64
  5. Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners. (PMID: 27100087) Alves da Silva A.F. … Medina-Acosta E. (PLoS ONE 2016) 3 64

Products for WRB Gene

Sources for WRB Gene

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