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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WRB Gene

protein-coding   GIFtS: 52
GCID: GC21P040752

Tryptophan Rich Basic Protein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

Aliases
Tryptophan Rich Basic Protein1 2     Tryptophan-Rich Protein, Congenital Heart Disease 5 Protein11
CHD52 3 5     Tail-Anchored Protein Insertion Receptor WRB2
Congenital Heart Disease 5 Protein2 3     Tryptophan-Rich Protein2
Tryptophan-Rich Basic Protein2 3     

External Ids:    HGNC: 127901   Entrez Gene: 74852   Ensembl: ENSG000001820937   OMIM: 6029155   UniProtKB: O002583   

Export aliases for WRB gene to outside databases

Previous GC identifers: GC21P037326 GC21P039673 GC21P039672 GC21P039674 GC21P026220


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WRB Gene:
This gene encodes a basic nuclear protein of unknown function. The gene is widely expressed in adult and fetal
tissues. Since the region proposed to contain the gene(s) for congenital heart disease (CHD) in Down syndrome
(DS) patients has been restricted to 21q22.2-22.3, this gene, which maps to 21q22.3, has a potential role in the
pathogenesis of Down syndrome congenital heart disease. Alternatively spliced transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Apr 2009)

GeneCards Summary for WRB Gene: 
WRB (tryptophan rich basic protein) is a protein-coding gene. Diseases associated with WRB include down syndrome, and autoimmune hemolytic anemia.

UniProtKB/Swiss-Prot: WRB_HUMAN, O00258
Function: Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NT_011512.11  NC_018932.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WRB gene promoter:
         AP-2rep   SRF   Pbx1a   GATA-3   SRF (504 AA)   Sox9   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): WRB promoter sequence

   Search SABiosciences Chromatin IP Primers for WRB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WRB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.2   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.2
WRB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WRB gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P040752:   GeneLoc Nature:405,311-319
Start:
40,752,170 bp from pter       26,325,991 bp from centromere
End:
40,800,454 bp from pter 26,343,350 bp from centromere
Size:
48,285 bases 17,360 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: Y12478
genomic clones: P128M19


(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WRB_HUMAN, O00258 (See protein sequence)
Recommended Name: Tail-anchored protein insertion receptor WRB  
Size: 174 amino acids; 19780 Da
Subunit: Interacts with ASNA1/TRC40
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Secondary accessions: A8KAP8 A8MQ44 D3DSH9 O60740
Alternative splicing: 2 isoforms:  O00258-1   O00258-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WRB: NX_O00258

Explore proteomics data for WRB at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00258

  • WRB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WRB Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001139690.1  NP_004618.2  

    ENSEMBL proteins: 
     ENSP00000327716   ENSP00000381737   ENSP00000409030   ENSP00000370089   ENSP00000370084  
     ENSP00000410228   ENSP00000445363  

    Human Recombinant Protein Products for WRB: 
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    OriGene Protein Over-expression Lysate for WRB
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    Novus Biologicals WRB Proteins
    Novus Biologicals WRB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WRB 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--

    WRB for ontologies           About GeneDecksing



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    LSBio Antibodies in human, mouse, rat for WRB 

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    Cloud-Clone Corp. CLIAs for WRB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: O00258

    UniProtKB/Swiss-Prot: WRB_HUMAN, O00258
    Similarity: Belongs to the WRB/GET1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WRB_HUMAN, O00258
    Function: Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane

         Genatlas biochemistry entry for WRB:
    tryptophan-rich basic protein,with two copies in the same region or a gene and a pseudogene,expressed in
    fibroblast derived from fetal endocardial structures,potential transcriptional factor

    Phenotypes:
         2 GenomeRNAi human phenotypes for WRB:
     Increased G1 DNA content  Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for WRB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for WRB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WRB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WRB 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WRB
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate WRB:
    hsa-miR-3163 hsa-miR-182 hsa-miR-4255 hsa-miR-145 hsa-miR-3065-5p hsa-miR-34a*
    SwitchGear 3'UTR luciferase reporter plasmidWRB 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of WRB

    Clone
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    OriGene clones in human, mouse for WRB (see all 13)
    OriGene ORF clones in mouse, rat for WRB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): WRB (NM_004627)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WRB
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                         Customized lentivirus expression plasmids for stable overexpression of WRB 

    Cell Line
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    Search LifeMap BioReagents cell lines for WRB
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WRB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WRB

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for WRB (ENSP000003277164) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    WRB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WRB

    10 Novoseek inferred chemical compound relationships for WRB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylcholine 47.6 1 18234676 (1)
    hocl 46.9 3 14671042 (1), 15807192 (1)
    phosphatidylserine 36.5 1 17765009 (1)
    iodide 35.5 2 7512826 (1), 8718891 (1)
    polyacrylamide 24.9 3 2340286 (1), 8718891 (1)
    lipid 23.4 3 8889194 (1), 18234676 (1), 7512826 (1)
    ozone 23.1 1 9028865 (1)
    methionine 12.8 1 15591095 (1)
    cysteine 12.3 1 12551937 (1)
    tyrosine 0 3 2106517 (1), 10439915 (1), 18208457 (1)

    Search CenterWatch for drugs/clinical trials and news about WRB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WRB gene (2 alternative transcripts): 
    NM_001146218.1  NM_004627.4  

    Unigene Cluster for WRB:

    Tryptophan rich basic protein
    Hs.744958  [show with all ESTs]
    Unigene Representative Sequence: NM_004627
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000333781(uc002yxs.3) ENST00000487869(uc011aep.1) ENST00000471468
    ENST00000398753 ENST00000442773 ENST00000380713 ENST00000380708(uc002yxt.4 uc010goj.3)
    ENST00000466787(uc011aeo.1) ENST00000490860 ENST00000415847 ENST00000478273
    ENST00000476914 ENST00000480690 ENST00000541890
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WRB
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate WRB:
    hsa-miR-3163 hsa-miR-182 hsa-miR-4255 hsa-miR-145 hsa-miR-3065-5p hsa-miR-34a*
    SwitchGear 3'UTR luciferase reporter plasmidWRB 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for WRB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WRB
    Clone
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    OriGene clones in human, mouse for WRB (see all 13)
    OriGene ORF clones in mouse, rat for WRB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): WRB (NM_004627)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WRB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WRB
    Sirion Biotech Customized lentivirus for stable overexpression of WRB 
                         Customized lentivirus expression plasmids for stable overexpression of WRB 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for WRB
    OriGene qSTAR qPCR primer pairs in human, mouse for WRB
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WRB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WRB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WRB

    Additional mRNA sequence: 

    AK293113.1 AK297186.1 AK299144.1 AK299245.1 AK310268.1 BC012415.1 BC111393.1 Y12478.1 

    18 DOTS entries:

    DT.100784071  DT.317368  DT.97846232  DT.121139444  DT.121139445  DT.100650176  DT.95153764  DT.100784072 
    DT.92445629  DT.121139419  DT.91747501  DT.121139478  DT.92445622  DT.97785365  DT.97846231  DT.204294 
    DT.91895956  DT.95147285 

    24/393 AceView cDNA sequences (see all 393):

    BQ771788 AI076545 BE645493 CB113614 BM128577 AI696477 BM669961 BM698634 
    AI934908 CB988076 CR618183 BE673753 CA391782 BU729884 AA099383 NM_001001713 
    AI074642 CA419722 CB114295 BP368925 BG742101 BM703010 AU142922 BQ574343 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for WRB (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
    SP1:                                                              -     -     -                 -                                             
    SP2:                          -     -     -     -                 -     -     -                 -                                             
    SP3:                                -     -     -                 -     -     -                 -                                             
    SP4:                                                              -     -     -           -     -     -                                       
    SP5:                                                                                            -                                             


    ECgene alternative splicing isoforms for WRB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WRB expression in normal human tissues (normalized intensities)      WRB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCATTGTT
    WRB Expression
    About this image


    WRB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Thalamus
             Olfactory Bulb   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             skeleton/cranium/viscerocranium   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             skeleton/cranium/viscerocranium   
     
     Tooth (Integumentary System)    fully expand to see all 2 entries
             visceral organ/oral region/upper jaw   
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium/viscerocranium   

    See WRB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WRB

    SOURCE GeneReport for Unigene cluster: Hs.744958
        SABiosciences Custom PCR Arrays for WRB
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WRB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WRB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for WRB gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wrb1 , 5 tryptophan rich basic protein1, 5 86.21(n)1
    93.1(a)1
      16 (56.84 cM)5
    714461  NM_207301.21  NP_997184.11 
     961454075 
    chicken
    (Gallus gallus)
    Aves WRB1 tryptophan rich basic protein 79.89(n)
    86.51(a)
      770415  NM_001079497.1  NP_001072965.1 
    lizard
    (Anolis carolinensis)
    Reptilia WRB6
    Uncharacterized protein
    76(a)
    1 ↔ 1
    3(139695040-139704461)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.114762 Xenopus laevis transcribed sequence with moderate similarity more 72.81(n)    CD362029.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wuft06h052 wuft06h05 75.86(n)   335756  BM026383.1 


    ENSEMBL Gene Tree for WRB (if available)
    TreeFam Gene Tree for WRB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WRB gene

    WRB for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for WRB
    PGOHUM00000250729


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/443 SNPs in WRB are shown (see all 443)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1409554841,2
    --40750318(+) CTCCTG/TCTCTT 1 -- us2k10--------
    rs110884731,2
    C,F,H--40750401(+) ATAGTT/GTTGCT 1 -- us2k115Minor allele frequency- G:0.05NS EA NA WA 2218
    rs28369961,2
    C,F,O,H--40750439(+) GTAGAA/CCCACA 1 -- us2k111Minor allele frequency- C:0.22NA NS EA WA CSA 787
    rs2013556101,2
    C--40750451(+) CCTCT-/TTCTTTTC 1 -- us2k10--------
    rs2017437081,2
    C--40750521(+) CTTTC-/TTTTCT 1 -- us2k10--------
    rs1855969921,2
    --40750551(+) TTTCTG/TTCTTT 1 -- us2k10--------
    rs1905232191,2
    --40750555(+) TTTCTC/TTCTTT 1 -- us2k10--------
    rs1930879851,2
    --40750559(+) TTTCTC/TTCTTT 1 -- us2k10--------
    rs1853508091,2
    C--40750563(+) TTTCTC/G/TTCTTT 1 -- us2k10--------
    rs665197581,2
    C--40750567(-) GAGAC-/AGAAA 
     GAAAGAA
    AGAAA
    1 -- us2k11Minor allele frequency- AGAAAGAAAGAA:0.00NA 2

    HapMap Linkage Disequilibrium report for WRB (40752170 - 40800454 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for WRB:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv913744CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing WRB
    DNA2.0 Custom Variant and Variant Library Synthesis for WRB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602915    OMIM disorders: --

    6 diseases for WRB:    About MalaCards
    down syndrome    autoimmune hemolytic anemia    anxiety disorder    hemolytic anemia
    anemia    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for WRB:
    Autoimmune hemolytic anemia

    WRB for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: WRB (1 document)

    Export disorders for WRB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WRB gene, integrated from 9 sources (see all 57):
    (articles sorted by number of sources associating them with WRB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a new human cDNA from chromosome 21q22.3 encoding a basic nuclear protein. (PubMed id 9544840)1, 2, 3, 9 Egeo A.... Scartezzini P. (1998)
    2. WRB is the receptor for TRC40/Asna1-mediated insertion of tail- anchored proteins into the ER membrane. (PubMed id 21444755)1, 2 Vilardi F.... Dobberstein B. (2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
    5. Molecular machinery for insertion of tail-anchored mem brane proteins into the endoplasmic reticulum membrane in mammalian cells. (PubMed id 23041287)1 Yamamoto Y. and Sakisaka T. (2012)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Replication of previous genome-wide association studi es of bone mineral density in premenopausal American women. (PubMed id 20200978)1 Ichikawa S....Econs M.J. (2010)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7485 HGNC: 12790 AceView: WRBandSH3BGR Ensembl:ENSG00000182093 euGenes: HUgn7485
    ECgene: WRB H-InvDB: WRB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WRB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WRB gene:
    Search GeneIP for patents involving WRB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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