Aliases for WRB Gene
External Ids for WRB Gene
Previous GeneCards Identifiers for WRB Gene
This gene is located in the candidate region for congenital heart disease (CHD) in Down syndrome (DS). It encodes a basic protein that functions as a receptor that promotes insertion of tail-anchored proteins in the endoplasmic reticulum membrane. This gene is located at a maternally-methylated differentially methylated region (DMR); however, its transcription may be biallelic, not imprinted. Alternative splicing results in different transcript variants. A pseudogene has been defined on chromosome 4. [provided by RefSeq, Apr 2017]
GeneCards Summary for WRB Gene
UniProtKB/Swiss-Prot for WRB Gene
Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane.