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Aliases for WRAP73 Gene

Aliases for WRAP73 Gene

  • WD Repeat Containing, Antisense To TP73 2 3
  • WD Repeat Domain 8 2 3
  • WDR8 3 4
  • WD Repeat-Containing Protein Antisense To TP73 Gene 4
  • WD Repeat-Containing Protein 8 4

External Ids for WRAP73 Gene

Previous HGNC Symbols for WRAP73 Gene

  • WDR8

Previous GeneCards Identifiers for WRAP73 Gene

  • GC01M003547

Summaries for WRAP73 Gene

Entrez Gene Summary for WRAP73 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Studies of the related mouse protein suggest that the encoded protein may play a role in the process of ossification. [provided by RefSeq, Mar 2009]

GeneCards Summary for WRAP73 Gene

WRAP73 (WD Repeat Containing, Antisense To TP73) is a Protein Coding gene.

Gene Wiki entry for WRAP73 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WRAP73 Gene

Genomics for WRAP73 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WRAP73 Gene

Chromosome:
1
Start:
3,630,767 bp from pter
End:
3,652,761 bp from pter
Size:
21,995 bases
Orientation:
Minus strand

Genomic View for WRAP73 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WRAP73 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WRAP73 Gene

No data available for Regulatory Elements for WRAP73 Gene

Proteins for WRAP73 Gene

  • Protein details for WRAP73 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2S5-WRP73_HUMAN
    Recommended name:
    WD repeat-containing protein WRAP73
    Protein Accession:
    Q9P2S5
    Secondary Accessions:
    • Q5T0D6
    • Q9BUH7
    • Q9NTK7
    • Q9NX56

    Protein attributes for WRAP73 Gene

    Size:
    460 amino acids
    Molecular mass:
    51588 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI14336.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI19129.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for WRAP73 Gene

Proteomics data for WRAP73 Gene at MOPED

Post-translational modifications for WRAP73 Gene

  • Ubiquitination at Lys 307, Lys 321, and Lys 330
  • Modification sites at PhosphoSitePlus

Other Protein References for WRAP73 Gene

No data available for DME Specific Peptides for WRAP73 Gene

Domains & Families for WRAP73 Gene

Gene Families for WRAP73 Gene

Protein Domains for WRAP73 Gene

Suggested Antigen Peptide Sequences for WRAP73 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P2S5

UniProtKB/Swiss-Prot:

WRP73_HUMAN :
  • Contains 6 WD repeats.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with WRAP73: view

Function for WRAP73 Gene

Gene Ontology (GO) - Molecular Function for WRAP73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with WRAP73: view

Phenotypes for WRAP73 Gene

genes like me logo Genes that share phenotypes with WRAP73: view

Animal Model Products

CRISPR Products

miRNA for WRAP73 Gene

miRTarBase miRNAs that target WRAP73

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WRAP73

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for WRAP73 Gene

Localization for WRAP73 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WRAP73 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WRAP73 Gene COMPARTMENTS Subcellular localization image for WRAP73 gene
Compartment Confidence
cytoskeleton 5
nucleus 2

Gene Ontology (GO) - Cellular Components for WRAP73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
genes like me logo Genes that share ontologies with WRAP73: view

Pathways & Interactions for WRAP73 Gene

SuperPathways for WRAP73 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WRAP73 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WRAP73 Gene

Drugs & Compounds for WRAP73 Gene

No Compound Related Data Available

Transcripts for WRAP73 Gene

Unigene Clusters for WRAP73 Gene

WD repeat containing, antisense to TP73:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WRAP73

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WRAP73 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP1: -
SP2:
SP3:

Relevant External Links for WRAP73 Gene

GeneLoc Exon Structure for
WRAP73
ECgene alternative splicing isoforms for
WRAP73

Expression for WRAP73 Gene

mRNA expression in normal human tissues for WRAP73 Gene

Protein differential expression in normal tissues from HIPED for WRAP73 Gene

This gene is overexpressed in Bone (31.8) and Testis (15.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WRAP73 Gene



SOURCE GeneReport for Unigene cluster for WRAP73 Gene Hs.31714

mRNA Expression by UniProt/SwissProt for WRAP73 Gene

Q9P2S5-WRP73_HUMAN
Tissue specificity: Ubiquitous. Predominant expression in heart, brain, liver, thymus, prostate, and testis, and barely detectable expression in lung
genes like me logo Genes that share expression patterns with WRAP73: view

Protein tissue co-expression partners for WRAP73 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for WRAP73 Gene

Orthologs for WRAP73 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WRAP73 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WRAP73 35
  • 84.79 (n)
  • 87.77 (a)
WRAP73 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WRAP73 35
  • 86.3 (n)
  • 89.78 (a)
WRAP73 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wrap73 35
  • 84.57 (n)
  • 88.65 (a)
Wrap73 16
Wrap73 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WRAP73 35
  • 99.06 (n)
  • 99.13 (a)
WRAP73 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wrap73 35
  • 84.46 (n)
  • 87.96 (a)
oppossum
(Monodelphis domestica)
Mammalia WRAP73 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WRAP73 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves WRAP73 35
  • 73.17 (n)
  • 78.7 (a)
WRAP73 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WRAP73 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75994 35
wrap73 35
  • 70.93 (n)
  • 76.23 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7927 35
zebrafish
(Danio rerio)
Actinopterygii wrap73 35
  • 69.68 (n)
  • 72.69 (a)
wufi45a07 35
wrap73 36
  • 72 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G07590 35
  • 52.83 (n)
  • 47.02 (a)
rice
(Oryza sativa)
Liliopsida Os10g0563300 35
  • 55.07 (n)
  • 51.03 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6483 36
  • 51 (a)
OneToOne
Species with no ortholog for WRAP73:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WRAP73 Gene

ENSEMBL:
Gene Tree for WRAP73 (if available)
TreeFam:
Gene Tree for WRAP73 (if available)

Paralogs for WRAP73 Gene

No data available for Paralogs for WRAP73 Gene

Variants for WRAP73 Gene

Sequence variations from dbSNP and Humsavar for WRAP73 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1004649 -- 3,649,869(+) GGCCC(G/T)GCCCG intron-variant
rs1046926 -- 3,630,965(-) GGTGC(A/C)CTAAC utr-variant-3-prime, nc-transcript-variant
rs1885864 -- 3,638,424(-) CAGCC(A/G)ATGCC intron-variant
rs2181485 -- 3,631,778(-) GCAGC(C/T)GCCCC intron-variant
rs2244942 -- 3,631,978(-) GCTCC(A/G)CTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WRAP73 Gene

Variant ID Type Subtype PubMed ID
nsv871581 CNV Loss 21882294
dgv95n71 CNV Loss 21882294
dgv96n71 CNV Loss 21882294
nsv470687 CNV Loss 18288195
dgv12e1 CNV Complex 17122850
dgv99n71 CNV Loss 21882294
dgv103n71 CNV Loss 21882294
nsv871823 CNV Loss 21882294
nsv871942 CNV Loss 21882294
dgv109n71 CNV Loss 21882294
dgv110n71 CNV Loss 21882294
dgv111n71 CNV Loss 21882294
dgv112n71 CNV Loss 21882294
nsv870859 CNV Loss 21882294
nsv410 CNV Insertion 18451855
esv2728584 CNV Deletion 23290073
esv2247294 CNV Deletion 18987734
esv2489412 CNV Deletion 19546169
esv2728695 CNV Deletion 23290073
esv29463 CNV Loss 19812545
esv1007908 CNV Deletion 20482838
esv2728806 CNV Deletion 23290073
esv2728917 CNV Deletion 23290073

Variation tolerance for WRAP73 Gene

Residual Variation Intolerance Score: 43.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.95; 68.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WRAP73 Gene

HapMap Linkage Disequilibrium report
WRAP73

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WRAP73 Gene

Disorders for WRAP73 Gene

Relevant External Links for WRAP73

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WRAP73
genes like me logo Genes that share disorders with WRAP73: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WRAP73 Gene

Publications for WRAP73 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. (PMID: 21399614) Jakobsen L. … Andersen J.S. (EMBO J. 2011) 67
  3. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 67
  4. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 67
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 67

Products for WRAP73 Gene

Sources for WRAP73 Gene

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