WRAP73 Gene
protein-coding GIFtS: 45
GCID: GC01M003547
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|
WD repeat containing, antisense to TP73(Previous name: WD repeat domain 8 )
(Previous symbol: WDR8)
| |
Aliases
for WRAP73 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WD Repeat Containing, Antisense To TP731 2 | | WD Repeat-Containing Protein WRAP732 | | WDR81 2 3 5 | | WD Repeat-Containing Protein 83 | | WD Repeat Domain 81 2 | | WD Repeat-Containing Protein Antisense To TP73 Gene3 | | WD Repeat-Containing Protein Antisense To TP732 | | |
Export aliases for WRAP73 gene to outside databases |
Summaries
for WRAP73 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for WRAP73:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric ormultiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycleprogression, signal transduction, apoptosis, and gene regulation. Studies of the related mouse protein suggest thatthe encoded protein may play a role in the process of ossification. (provided by RefSeq, Mar 2009)
Gene Wiki entry for WRAP73 (WDR8)
|
Genomic Views
for WRAP73 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004350.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for WRAP73
Other transcription factors
Search SABiosciences Chromatin IP Primers for WRAP73
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WRAP73 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.3 Ensembl cytogenetic band: 1p36.32 HGNC cytogenetic band: 1p36.3WRAP73 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M003547: view genomic region
(about GC identifiers)
Start:
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3,547,331 bp from pter |
End:
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3,569,325 bp from pter |
Size:
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21,995 bases |
Orientation:
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minus strand |
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Proteins
for WRAP73 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WRP73_HUMAN, Q9P2S5 (See
protein sequence)Recommended Name: WD repeat-containing protein WRAP73 Size: 460 amino acids; 51588 Da
Subcellular location: Cytoplasm (Potential)
Sequence caution: Sequence=CAI14336.1; Type=Erroneous gene model prediction; Sequence=CAI19129.1; Type=Erroneous genemodel prediction;
Secondary accessions: Q5T0D6 Q9BUH7 Q9NTK7 Q9NX56Explore the universe of human proteins at neXtProt for WRAP73: NX_Q9P2S5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9P2S5
WRAP73 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060288.3
ENSEMBL proteins: ENSP00000367573 ENSP00000270708 ENSP00000416192 ENSP00000463084 ENSP00000389738
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
WRAP73 for ontologies About GeneDecksing
WRAP73 Antibody Products:
Assay Products for WRAP73: |
Protein
Domains /
Families
for WRAP73 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WRAP73 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9P2S5ProtoNet protein and cluster: Q9P2S5 UniProtKB/Swiss-Prot: WRP73_HUMAN, Q9P2S5Similarity: Contains 6 WD repeats |
Function
for WRAP73 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WRAP73
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WRAP73
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WRAP73 |
1 GenomeRNAi human phenotype for WRAP73:
|
Pathways & Interactions
for WRAP73 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WRAP73
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/62 Interacting proteins for WRAP73 (Q9P2S53 ENSP000002707084) via UniProtKB, MINT, STRING, and/or I2D (see all 62)About this table
|
Drugs & Compounds
for WRAP73 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WRAP73
Search CenterWatch for drugs/clinical trials and news about WRAP73 / WRP73
|
Transcripts
for WRAP73 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WRAP73 gene: NM_017818.3 Unigene Cluster for WRAP73: WD repeat containing, antisense to TP73 Hs.31714 [show with all ESTs]Unigene Representative Sequence: BX53759110 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000378322(uc001akn.3) ENST00000270708(uc001ako.3) ENST00000471223(uc010nzi.2)
ENST00000424367 ENST00000497940 ENST00000469643 ENST00000494884 ENST00000465916
ENST00000419924 ENST00000479331
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WRAP73
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WRAP73
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for WRAP73 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WRAP73 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WRAP73 |
Additional cDNA sequence: AB034912.1 AK000437.1 AK225525.1 AK302397.1 BC086311.1 BX537591.1 EF494669.1 8 DOTS entries: DT.441549 DT.100023958 DT.412415 DT.100779746 DT.100779751 DT.412413 DT.100738496 DT.100779748 24/219 AceView cDNA sequences (see all 219): BE297532 BI759227 BM449854 CR613845 BX331531 BF000603 BQ949064 AW170680 CR596816 CA406587 BM055144 CR619231 BI826500 CR599166 AB034912 BP337192 AA886380 AW083552 AI567117 BF062303 BQ055343 BC002611 BI094072 BQ938290
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for WRAP73 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 |
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| SP1: | | | | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for WRAP73
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Expression
for WRAP73 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WRAP73 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCGGTGCAGG
About this image
See WRAP73 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WRAP73
SOURCE GeneReport for Unigene cluster: Hs.31714
UniProtKB/Swiss-Prot: WRP73_HUMAN, Q9P2S5Tissue specificity: Ubiquitous. Predominant expression in heart, brain, liver, thymus, prostate, and testis, and barelydetectable expression in lung
SABiosciences Custom PCR Arrays for WRAP73
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WRAP73
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WRAP73 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WRAP73 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WRAP73 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WRAP73 |
Orthologs
for WRAP73 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for WRAP73 gene from 7/26 species (see all 26) About this table
ENSEMBL Gene Tree for WRAP73 (if available)
TreeFam Gene Tree for WRAP73 (if available) |
Paralogs
for WRAP73 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for WRAP73 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WRAP73 (3547331 - 3569325 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for WRAP73: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WRAP73 |
|
Disorders
/ Diseases
for WRAP73 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WRAP73 for disorders About GeneDecksing
OMIM gene information: 606040
OMIM disorders: --
2  diseases for WRAP73: About MalaCardsmalaria prostatitis
Export disorders for WRAP73 gene to outside databases
|
Publications
for WRAP73 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WRAP73 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with WRAP73) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Isolation, characterization, and mapping of the mouse and human WDR8 genes, members of a novel WD-repeat gene family. (PubMed id 11401440)1, 2 Koshizuka Y.... Nakamura Y. (2001)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
|
External Searches for WRAP73 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WRAP73 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WRAP73 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WRAP73 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WRAP73 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WRAP73 gene:
Search GeneIP for patents involving WRAP73
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WRAP73 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for WRAP73 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WRAP73 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WRAP73 | | | OriGene Protein Over-expression Lysate for WRAP73 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for WRAP73 | | OriGene 3'-UTR Clone for WRAP73 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WRAP73 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WRAP73 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | WRAP73 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WRAP73 |
|  |  |  | | | | ThermoFisher Antibody for WRAP73 |
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