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WRAP53 Gene

protein-coding   GIFtS: 56
GCID: GC17P007589

WD Repeat Containing, Antisense To TP53

(Previous name: WD repeat domain 79)
(Previous symbol: WDR79)
  See WRAP53-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WD Repeat Containing, Antisense To TP531 2     WD40 Repeat-Containing Protein Encoding RNA Antisense To P532 3
WDR791 2 3 5     DKCB32 5
TCAB12 3 5     WD Repeat Domain 791
Telomerase Cajal Body Protein 11 2     WD-Encoding RNA Antisense To P531
WD Repeat-Containing Protein 792 3     WD40 Protein Wrap532

External Ids:    HGNC: 255221   Entrez Gene: 551352   Ensembl: ENSG000001414997   OMIM: 6126615   UniProtKB: Q9BUR43   

Export aliases for WRAP53 gene to outside databases

Previous GC identifers: GC17P007534 GC17P007483


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WRAP53 Gene:
This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex
required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that
are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active
telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA
also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of
p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which
differ only in the 5' UTR have been found for this gene. (provided by RefSeq, Mar 2011)

GeneCards Summary for WRAP53 Gene:
WRAP53 (WD repeat containing, antisense to TP53) is a protein-coding gene. Diseases associated with WRAP53 include dyskeratosis congenita, autosomal recessive 3, and wrap53-related dyskeratosis congenita. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: WAP53_HUMAN, Q9BUR4
Function: Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the
replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme
complex, it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S
phase and for telomerase activity. Binds small Cajal body RNAs (scaRNAs). The mRNA encoding this protein plays a
critical role in the regulation of p53 expression at the post-transcriptional level; it is involved both in
maintaining basal p53 mRNA levels and in p53 induction upon DNA damage




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WRAP53 gene promoter:
         C/EBPbeta   Sp1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): WRAP53 promoter sequence
   Search Chromatin IP Primers for WRAP53

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WRAP53


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

WRAP53 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WRAP53 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P007589:  view genomic region     (about GC identifiers)

Start:
7,589,389 bp from pter      End:
7,606,820 bp from pter
Size:
17,432 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: WAP53_HUMAN, Q9BUR4 (See protein sequence)
Recommended Name: Telomerase Cajal body protein 1  
Size: 548 amino acids; 59309 Da
Subunit: Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10,
NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC)
Secondary accessions: B3KPR9 D3DTQ4 Q08ET9 Q9NW09

Explore the universe of human proteins at neXtProt for WRAP53: NX_Q9BUR4

Explore proteomics data for WRAP53 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys173, Lys176
  • Modification sites at PhosphoSitePlus

  • See WRAP53 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001137462.1  NP_001137463.1  NP_001137464.1  NP_060551.2  

    ENSEMBL proteins: 
     ENSP00000397219   ENSP00000324203   ENSP00000411061   ENSP00000432991   ENSP00000379727  
     ENSP00000434999   ENSP00000465025  
    Reactome Protein details: Q9BUR4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    3 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9BUR4

    ProtoNet protein and cluster: Q9BUR4

    UniProtKB/Swiss-Prot: WAP53_HUMAN, Q9BUR4
    Similarity: Contains 6 WD repeats


    Find genes that share domains with WRAP53           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WAP53_HUMAN, Q9BUR4
    Function: Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the
    replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme
    complex, it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S
    phase and for telomerase activity. Binds small Cajal body RNAs (scaRNAs). The mRNA encoding this protein plays a
    critical role in the regulation of p53 expression at the post-transcriptional level; it is involved both in
    maintaining basal p53 mRNA levels and in p53 induction upon DNA damage

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IDA19179534
    GO:0005515protein binding IPI19179534
         
    Find genes that share ontologies with WRAP53           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for WRAP53:
     Elongated cells  Increased S DNA content  Increased gamma-H2AX phosphory 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WAP53_HUMAN, Q9BUR4: Nucleus, Cajal body. Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005697telomerase holoenzyme complex IDA19179534
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0015030Cajal body IDA19179534

    Find genes that share ontologies with WRAP53           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WRAP53 About    
    See pathways by source

    SuperPathContained pathways About
    1Telomere C-strand (Lagging Strand) Synthesis
    Extension of Telomeres0.79
    Telomere Extension By Telomerase0.00
    2Packaging Of Telomere Ends
    Telomere Maintenance0.64
    Chromosome Maintenance0.62
    3Cell Cycle, Mitotic
    Cell Cycle0.90


    Find genes that share SuperPaths with WRAP53           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for WRAP53
        Telomere Extension By Telomerase


        Pathway & Disease-focused RT2 Profiler PCR Array including WRAP53: 
              Telomeres & Telomerase in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for WRAP53

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for WRAP53 (ENSP000003242034) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TERTENSP000003095724STRING: ENSP00000309572
    TRNAU1APENSP000003629364STRING: ENSP00000362936
    NCBP2ENSP000003268064STRING: ENSP00000326806
    DKC1ENSP000003585634STRING: ENSP00000358563
    COILENSP000002403164STRING: ENSP00000240316
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032203telomere formation via telomerase IMP19179534
    GO:0051973positive regulation of telomerase activity IDA19179534

    Find genes that share ontologies with WRAP53           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WRAP53 (WAP53)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WRAP53 gene (4 alternative transcripts): 
    NM_001143990.1  NM_001143991.1  NM_001143992.1  NM_018081.2  

    Unigene Cluster for WRAP53:

    WD repeat containing, antisense to TP53
    Hs.408312  [show with all ESTs]
    Unigene Representative Sequence: AK056669
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000431639(uc010vuh.2) ENST00000316024(uc002gir.3 uc010cnl.3)
    ENST00000457584(uc010vui.2) ENST00000498311(uc002giq.3) ENST00000396463(uc002gip.3)
    ENST00000467699(uc010vuj.2) ENST00000534050 ENST00000463804 ENST00000471973
    ENST00000498114
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat WRAP53

    Additional mRNA sequence: 

    AK001247.1 AK056669.1 AK092370.1 AK225273.1 AK225411.1 AY766322.1 AY766323.1 BC002336.2 
    DQ431240.1 DQ431241.1 

    14 DOTS entries:

    DT.40276076  DT.445840  DT.120961418  DT.100791809  DT.100791797  DT.100712946  DT.101967939  DT.100791800 
    DT.100762063  DT.92432271  DT.100791798  DT.100791802  DT.92469229  DT.97855928 

    Selected AceView cDNA sequences (see all 201):

    BM926273 BG109721 CF242940 CR617478 CA417092 CR603263 CA426678 BI518521 
    CA431001 BM423498 BU849179 BM824406 AK092370 CB138687 BC002336 BM725682 
    BU681405 BE885631 CR615409 BM723308 BM552657 CF264929 CB138697 BQ644183 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for WRAP53    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                                                                    
    SP2:                                            -                                       
    SP3:                                            -                                       


    ECgene alternative splicing isoforms for WRAP53

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WRAP53 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGGGGAGCA
    WRAP53 Expression
    About this image


    WRAP53 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    WRAP53 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WRAP53 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.408312

    UniProtKB/Swiss-Prot: WAP53_HUMAN, Q9BUR4
    Tissue specificity: Expressed in all tissues and cell lines examined

        Pathway & Disease-focused RT2 Profiler PCR Array including WRAP53: 
              Telomeres & Telomerase in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WRAP53

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WRAP53 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wrap531 , 5 WD repeat containing, antisense to TP535
    WD repeat containing, antisense to Trp531
    82.53(n)1
    80.92(a)1
      11 (42.81 cM)5
    2168531  NM_144824.21  NP_659073.11 
     695617585 
    lizard
    (Anolis carolinensis)
    Reptilia WRAP536
    WD repeat containing, antisense to TP53
    61(a)
    1 ↔ 1
    AAWZ02037269(2715-17338)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.327032 Xenopus laevis transcribed sequence with weak similarity more 80.15(n)    BJ623681.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wrap531 WD repeat containing, antisense to TP53 60.5(n)
    55.29(a)
      321796  NM_001256028.1  NP_001242957.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta WDR791 WD repeat domain 79 homolog 49.92(n)
    41.71(a)
      33865  NM_135153.4  NP_608997.3 
    worm
    (Caenorhabditis elegans)
    Secernentea Y105E8A.86
    Protein Y105E8A.8 (Y105E8A.8) mRNA, complete cds
    22(a)
    1 ↔ 1
    I(14400681-14405649) WBGene00013669
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G215201 AT4G21520 52.19(n)
    46.25(a)
      828237  NM_118272.4  NP_193883.2 
    rice
    (Oryza sativa)
    Liliopsida Os03g07380001 Os03g0738000 51.01(n)
    45.08(a)
      4334044  NM_001057742.1  NP_001051207.1 


    ENSEMBL Gene Tree for WRAP53 (if available)
    TreeFam Gene Tree for WRAP53 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WRAP53 gene
    1 SIMAP similar gene for WRAP53 using alignment to 4 protein entries:     WAP53_HUMAN (see all proteins):
    WDR79

    Find genes that share paralogs with WRAP53           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WRAP53 (see all 379)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0658764
    Dyskeratosis congenita, autosomal recessive, 3 (DKCB3)4--see VAR_0658762 G R mis40--------
    VAR_0658734
    Dyskeratosis congenita, autosomal recessive, 3 (DKCB3)4--see VAR_0658732 F L mis40--------
    VAR_0658754
    Dyskeratosis congenita, autosomal recessive, 3 (DKCB3)4--see VAR_0658752 R W mis40--------
    VAR_0658744
    Dyskeratosis congenita, autosomal recessive, 3 (DKCB3)4--see VAR_0658742 H Y mis40--------
    rs2818655481,2
    Cpathogenic17595213(+) ATCTCC/TGGCAG 8 R W mis10--------
    rs1817520001,2
    --7585268(+) CATTCG/TCCTTT 4 -- int10--------
    rs1867168401,2
    --7585307(+) AGTCTC/TGCTCT 4 -- int10--------
    rs116510931,2
    C,F,H--7585331(+) agtgcG/Agtggc 4 -- int11Minor allele frequency- A:0.00CSA 1
    rs1157809111,2
    C,F--7585588(+) AAATTC/TGCCTC 4 -- int12Minor allele frequency- T:0.03WA NA 238
    rs1915629651,2
    --7585615(+) GCATGA/GGTCAC 4 -- int10--------

    HapMap Linkage Disequilibrium report for WRAP53 (7589389 - 7606820 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for WRAP53:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv457659CNV Loss19166990

    Human Gene Mutation Database (HGMD): WRAP53
    Locus Specific Mutation Databases (LSDB): WRAP53

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WRAP53
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612661   
    OMIM disorders: 613988  
    UniProtKB/Swiss-Prot: WAP53_HUMAN, Q9BUR4
  • Dyskeratosis congenita, autosomal recessive, 3 (DKCB3) [MIM:613988]: A rare multisystem disorder caused
    by defective telomere maintenance. It is characterized by progressive bone marrow failure, and the clinical triad
    of reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Common but variable features
    include premature graying, aplastic anemia, low platelets, osteoporosis, pulmonary fibrosis, and liver fibrosis
    among others. Early mortality is often associated with bone marrow failure, infections, fatal pulmonary
    complications, or malignancy. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • 4 diseases for WRAP53:    
    About MalaCards
    dyskeratosis congenita, autosomal recessive 3    wrap53-related dyskeratosis congenita    dyskeratosis congenita    dyskeratosis congenita, autosomal recessive 4

    1 disease from the University of Copenhagen DISEASES database for WRAP53:
    Dyskeratosis congenita

    Find genes that share disorders with WRAP53           About GenesLikeMe

    Genetic Association Database (GAD): WRAP53
    Human Genome Epidemiology (HuGE) Navigator: WRAP53 (0 documents)

    Export disorders for WRAP53 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WRAP53 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with WRAP53)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis. (PubMed id 19179534)1, 2, 3 Venteicher A.S.... Artandi S.E. (Science 2009)
    2. Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage. (PubMed id 19250907)1, 2, 3 Mahmoudi S....Farnebo M. (Mol. Cell 2009)
    3. Anthracyclines induce the accumulation of mutant p53 through E2F1-dependent and -independent mechanisms. (PubMed id 21441950)1, 3 Bug M. and Dobbelstein M. (Oncogene 2011)
    4. Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita. (PubMed id 21205863)1, 2 Zhong F.... Artandi S.E. (Genes Dev. 2011)
    5. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    6. The p53 tumor suppressor: a master regulator of diverse cellular processes and therapeutic target in cancer. (PubMed id 20494116)1, 3 Farnebo M....Wiman K.G. (Biochem. Biophys. Res. Commun. 2010)
    7. Wrap53, a novel regulator of p53. (PubMed id 19571673)1, 3 Farnebo M. (Cell Cycle 2009)
    8. Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project. (PubMed id 19339270)1, 4 Canova C....Brennan P. (Cancer Res. 2009)
    9. TCAB1: driving telomerase to Cajal bodies. (PubMed id 19342896)1, 3 Venteicher A.S. and Artandi S.E. (Cell Cycle 2009)
    10. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55135 HGNC: 25522 AceView: FLJ10385 Ensembl:ENSG00000141499 euGenes: HUgn55135
    ECgene: WRAP53 H-InvDB: WRAP53

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WRAP53 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WRAP53 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WRAP53 gene:
    Search GeneIP for patents involving WRAP53

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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