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Aliases for WRAP53 Gene

Aliases for WRAP53 Gene

  • WD Repeat Containing, Antisense To TP53 2 3
  • WDR79 3 4 6
  • TCAB1 3 4 6
  • WD Repeat-Containing Protein WRAP53 3 4
  • Telomerase Cajal Body Protein 1 2 3
  • WD Repeat-Containing Protein 79 3 4
  • DKCB3 3 6
  • WD40 Repeat-Containing Protein Encoding RNA Antisense To P53 3
  • WD40 Repeat-Containing Protein Antisense To TP53 Gene 4
  • WD40 Repeat-Containing Protein Antisense To TP53 3
  • WD-Encoding RNA Antisense To P53 2
  • WD Repeat Domain 79 2
  • WD40 Protein Wrap53 3

External Ids for WRAP53 Gene

Previous Symbols for WRAP53 Gene

  • WDR79

Summaries for WRAP53 Gene

Entrez Gene Summary for WRAP53 Gene

  • This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]

GeneCards Summary for WRAP53 Gene

WRAP53 (WD Repeat Containing, Antisense To TP53) is a Protein Coding gene. Diseases associated with WRAP53 include wrap53-related dyskeratosis congenita and dyskeratosis congenita, autosomal recessive 3. Among its related pathways are Cell Cycle, Mitotic and Telomere C-strand (Lagging Strand) Synthesis. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for WRAP53 Gene

  • Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and for telomerase activity. Binds small Cajal body RNAs (scaRNAs). The mRNA encoding this protein plays a critical role in the regulation of p53 expression at the post-transcriptional level; it is involved both in maintaining basal p53 mRNA levels and in p53 induction upon DNA damage.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WRAP53 Gene

Genomics for WRAP53 Gene

Genomic Location for WRAP53 Gene

Start:
7,686,071 bp from pter
End:
7,703,502 bp from pter
Size:
17,432 bases
Orientation:
Plus strand

Genomic View for WRAP53 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WRAP53 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WRAP53 Gene

Regulatory Elements for WRAP53 Gene

Proteins for WRAP53 Gene

  • Protein details for WRAP53 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUR4-WAP53_HUMAN
    Recommended name:
    Telomerase Cajal body protein 1
    Protein Accession:
    Q9BUR4
    Secondary Accessions:
    • B3KPR9
    • D3DTQ4
    • Q08ET9
    • Q9NW09

    Protein attributes for WRAP53 Gene

    Size:
    548 amino acids
    Molecular mass:
    59309 Da
    Quaternary structure:
    • Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC).

neXtProt entry for WRAP53 Gene

Proteomics data for WRAP53 Gene at MOPED

Post-translational modifications for WRAP53 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys173 and Lys176

Other Protein References for WRAP53 Gene

No data available for DME Specific Peptides for WRAP53 Gene

Domains for WRAP53 Gene

Gene Families for WRAP53 Gene

HGNC:
  • WDR :WD repeat domain containing

Protein Domains for WRAP53 Gene

UniProtKB/Swiss-Prot:

WAP53_HUMAN
Similarity:
  • Contains 6 WD repeats.:
    • Q9BUR4
genes like me logo Genes that share domains with WRAP53: view

Function for WRAP53 Gene

Molecular function for WRAP53 Gene

UniProtKB/Swiss-Prot Function: Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and for telomerase activity. Binds small Cajal body RNAs (scaRNAs). The mRNA encoding this protein plays a critical role in the regulation of p53 expression at the post-transcriptional level; it is involved both in maintaining basal p53 mRNA levels and in p53 induction upon DNA damage.

Gene Ontology (GO) - Molecular Function for WRAP53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 19179534
GO:0005515 protein binding IPI 19179534
genes like me logo Genes that share ontologies with WRAP53: view

Phenotypes for WRAP53 Gene

genes like me logo Genes that share phenotypes with WRAP53: view

miRNA for WRAP53 Gene

miRTarBase miRNAs that target WRAP53

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for WRAP53 Gene

Localization for WRAP53 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WRAP53 Gene

Nucleus, Cajal body. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WRAP53 Gene COMPARTMENTS Subcellular localization image for WRAP53 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for WRAP53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005697 telomerase holoenzyme complex IDA 19179534
GO:0005737 cytoplasm IDA --
GO:0015030 Cajal body IDA 19179534
genes like me logo Genes that share ontologies with WRAP53: view

Pathways for WRAP53 Gene

genes like me logo Genes that share pathways with WRAP53: view

Pathways by source for WRAP53 Gene

Interacting Proteins for WRAP53 Gene

Gene Ontology (GO) - Biological Process for WRAP53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032203 telomere formation via telomerase IMP 19179534
GO:0051973 positive regulation of telomerase activity IDA 19179534
genes like me logo Genes that share ontologies with WRAP53: view

Transcripts for WRAP53 Gene

Unigene Clusters for WRAP53 Gene

WD repeat containing, antisense to TP53:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WRAP53 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2: -
SP3: -

Relevant External Links for WRAP53 Gene

GeneLoc Exon Structure for
WRAP53
ECgene alternative splicing isoforms for
WRAP53

Expression for WRAP53 Gene

mRNA expression in normal human tissues for WRAP53 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WRAP53 Gene

SOURCE GeneReport for Unigene cluster for WRAP53 Gene Hs.408312

mRNA Expression by UniProt/SwissProt for WRAP53 Gene

Q9BUR4-WAP53_HUMAN
Tissue specificity: Expressed in all tissues and cell lines examined.
genes like me logo Genes that share expressions with WRAP53: view

Orthologs for WRAP53 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WRAP53 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WRAP53 36
  • 99.45 (n)
  • 99.09 (a)
WRAP53 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WRAP53 36
  • 87.94 (n)
  • 84.57 (a)
WRAP53 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WRAP53 36
  • 84.72 (n)
  • 83.3 (a)
WRAP53 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wrap53 36
  • 82.53 (n)
  • 80.92 (a)
Wrap53 16
Wrap53 37
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WRAP53 37
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WRAP53 37
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wrap53 36
  • 82.98 (n)
  • 81.31 (a)
lizard
(Anolis carolinensis)
Reptilia WRAP53 37
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32703 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10050 36
zebrafish
(Danio rerio)
Actinopterygii wrap53 36
  • 60.5 (n)
  • 55.29 (a)
wrap53 37
  • 46 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001885 36
  • 50.29 (n)
  • 38.08 (a)
fruit fly
(Drosophila melanogaster)
Insecta WDR79 36
  • 49.92 (n)
  • 41.71 (a)
WDR79 37
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y105E8A.8 37
  • 22 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G21520 36
  • 52.19 (n)
  • 46.25 (a)
rice
(Oryza sativa)
Liliopsida Os03g0738000 36
  • 51.01 (n)
  • 45.08 (a)
Species with no ortholog for WRAP53:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for WRAP53 Gene

ENSEMBL:
Gene Tree for WRAP53 (if available)
TreeFam:
Gene Tree for WRAP53 (if available)

Paralogs for WRAP53 Gene

Selected SIMAP similar genes for WRAP53 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with WRAP53: view

No data available for Paralogs for WRAP53 Gene

Variants for WRAP53 Gene

Sequence variations from dbSNP and Humsavar for WRAP53 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1046823 -- 7,703,061(+) GCCTG(G/T)CAATG reference, missense, nc-transcript-variant
rs4559962 -- 7,691,392(-) aaaaa(A/C)aCCTC intron-variant
rs4968205 -- 7,694,463(+) gtctc(A/G)aactc intron-variant
rs6503050 -- 7,690,191(+) ggatc(C/T)gccca intron-variant
rs6503051 -- 7,690,222(+) gggat(C/T)acagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WRAP53 Gene

Variant ID Type Subtype PubMed ID
nsv457659 CNV Loss 19166990

Relevant External Links for WRAP53 Gene

HapMap Linkage Disequilibrium report
WRAP53
Human Gene Mutation Database (HGMD)
WRAP53
Locus Specific Mutation Databases (LSDB)
WRAP53

Disorders for WRAP53 Gene

(1) OMIM Diseases for WRAP53 Gene (612661)

UniProtKB/Swiss-Prot

WAP53_HUMAN
  • Dyskeratosis congenita, autosomal recessive, 3 (DKCB3) [MIM:613988]: A rare multisystem disorder caused by defective telomere maintenance. It is characterized by progressive bone marrow failure, and the clinical triad of reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Common but variable features include premature graying, aplastic anemia, low platelets, osteoporosis, pulmonary fibrosis, and liver fibrosis among others. Early mortality is often associated with bone marrow failure, infections, fatal pulmonary complications, or malignancy. {ECO:0000269 PubMed:21205863}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for WRAP53 Gene

Relevant External Links for WRAP53

Genetic Association Database (GAD)
WRAP53
Human Genome Epidemiology (HuGE) Navigator
WRAP53
genes like me logo Genes that share disorders with WRAP53: view

Publications for WRAP53 Gene

  1. A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis. (PMID: 19179534) Venteicher A.S. … Artandi S.E. (Science 2009) 2 3 4
  2. Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage. (PMID: 19250907) Mahmoudi S. … Farnebo M. (Mol. Cell 2009) 2 3 4
  3. Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project. (PMID: 19339270) Canova C. … Brennan P. (Cancer Res. 2009) 3 49
  4. TCAB1: driving telomerase to Cajal bodies. (PMID: 19342896) Venteicher A.S. … Artandi S.E. (Cell Cycle 2009) 2 3
  5. Wrap53, a novel regulator of p53. (PMID: 19571673) Farnebo M. (Cell Cycle 2009) 2 3

Products for WRAP53 Gene

Sources for WRAP53 Gene

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