WRAP53 Gene
protein-coding GIFtS: 49
GCID: GC17P007589
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|
WD repeat containing, antisense to TP53(Previous name: WD repeat domain 79 )
(Previous symbol: WDR79)
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Aliases
for WRAP53 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WD Repeat Containing, Antisense To TP531 2 | | FLJ103851 | | TCAB11 2 3 5 | | WD Repeat Domain 791 | | WDR791 2 3 5 | | DKCB32 | | WD Repeat-Containing Protein 792 3 | | Telomerase Cajal Body Protein 12 | | WD40 Repeat-Containing Protein Encoding RNA Antisense To P532 3 | | WD40 Protein Wrap532 |
Export aliases for WRAP53 gene to outside databasesPrevious GC identifers: GC17P007534 GC17P007483 |
Summaries
for WRAP53 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for WRAP53:
This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required fortelomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important fortelomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with smallCajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisensetranscript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5'untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have beenfound for this gene. (provided by RefSeq, Mar 2011)
UniProtKB/Swiss-Prot: WAP53_HUMAN, Q9BUR4Function: Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for thereplication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex,it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and fortelomerase activity. Binds small Cajal body RNAs (scaRNAs). The mRNA encoding this protein plays a critical role inthe regulation of p53 expression at the post-transcriptional level; it is involved both in maintaining basal p53 mRNAlevels and in p53 induction upon DNA damage
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Genomic Views
for WRAP53 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WRAP53 gene promoter:
C/EBPbeta Sp1 deltaCREB
Other transcription factors
Search SABiosciences Chromatin IP Primers for WRAP53
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WRAP53 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13.1WRAP53 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P007589: view genomic region
(about GC identifiers)
Start:
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7,589,389 bp from pter |
End:
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7,606,820 bp from pter |
Size:
|
17,432 bases |
Orientation:
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plus strand |
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Proteins
for WRAP53 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WAP53_HUMAN, Q9BUR4 (See
protein sequence)Recommended Name: Telomerase Cajal body protein 1 Size: 548 amino acids; 59309 Da
Subunit: Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2,GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC)
Subcellular location: Nucleus, Cajal body. Cytoplasm
Secondary accessions: B3KPR9 D3DTQ4 Q08ET9 Q9NW09Explore the universe of human proteins at neXtProt for WRAP53: NX_Q9BUR4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BUR4
WRAP53 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001137462.1 NP_001137463.1 NP_001137464.1 NP_060551.2
ENSEMBL proteins: ENSP00000397219 ENSP00000324203 ENSP00000411061 ENSP00000432991 ENSP00000379727 ENSP00000434999 ENSP00000465025
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
WRAP53 for ontologies About GeneDecksing
WRAP53 Antibody Products:
Assay Products for WRAP53: |
Protein
Domains /
Families
for WRAP53 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WRAP53 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BUR4ProtoNet protein and cluster: Q9BUR4 UniProtKB/Swiss-Prot: WAP53_HUMAN, Q9BUR4Similarity: Contains 6 WD repeats |
Function
for WRAP53 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: WAP53_HUMAN, Q9BUR4Function: Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for thereplication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex,it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and fortelomerase activity. Binds small Cajal body RNAs (scaRNAs). The mRNA encoding this protein plays a critical role inthe regulation of p53 expression at the post-transcriptional level; it is involved both in maintaining basal p53 mRNAlevels and in p53 induction upon DNA damage
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WRAP53 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WRAP53 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
WRAP53 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for WRAP53:
|
Pathways & Interactions
for WRAP53 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WRAP53
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5 Interacting proteins for WRAP53 (ENSP000003242034) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
WRAP53 for ontologies About GeneDecksing
|
Drugs & Compounds
for WRAP53 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WRAP53
Search CenterWatch for drugs/clinical trials and news about WRAP53 / WAP53
|
Transcripts
for WRAP53 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WRAP53 gene (4 alternative transcripts): NM_001143990.1 NM_001143991.1 NM_001143992.1 NM_018081.2 Unigene Cluster for WRAP53: WD repeat containing, antisense to TP53 Hs.408312 [show with all ESTs]Unigene Representative Sequence: AK05666910 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000431639(uc010vuh.2) ENST00000316024(uc002gir.3 uc010cnl.3)
ENST00000457584(uc010vui.2) ENST00000498311(uc002giq.3) ENST00000396463(uc002gip.3)
ENST00000467699(uc010vuj.2) ENST00000534050 ENST00000463804 ENST00000471973
ENST00000498114
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WRAP53 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WRAP53 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
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Additional cDNA sequence: AK001247.1 AK056669.1 AK092370.1 AK097045.1 AK225273.1 AK225411.1 AY766322.1 AY766323.1 BC002336.2 DQ431240.1 DQ431241.1 15 DOTS entries: DT.40276076 DT.445840 DT.120961418 DT.100791809 DT.100791797 DT.100712946 DT.101967939 DT.100791800 DT.100762063 DT.92432271 DT.97785795 DT.100791798 DT.100791802 DT.92469229 DT.97855928 24/201 AceView cDNA sequences (see all 201): AX747505 BQ651069 CR622832 BM725682 CR624035 CB138697 BI518521 CR617478 BG109721 CA431001 BC002336 BM723308 BM552657 CB138687 CA417092 CF264929 CF142453 BM678289 BU681405 BM824406 CA426678 CA487183 BM423498 BM926273
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for WRAP53 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for WRAP53
|
Expression
for WRAP53 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WRAP53 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGGGGAGCA
About this image
See WRAP53 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WRAP53
SOURCE GeneReport for Unigene cluster: Hs.408312
UniProtKB/Swiss-Prot: WAP53_HUMAN, Q9BUR4Tissue specificity: Expressed in all tissues and cell lines examined
SABiosciences Expression via Pathway-Focused PCR Array including WRAP53:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WRAP53
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WRAP53 |
Orthologs
for WRAP53 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for WRAP53 gene from 8/28 species (see all 28) About this table
ENSEMBL Gene Tree for WRAP53 (if available)
TreeFam Gene Tree for WRAP53 (if available) |
Paralogs
for WRAP53 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for WRAP53 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WRAP53 (7589389 - 7606820 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for WRAP53: --
Human Gene Mutation Database (HGMD): WRAP53
Locus Specific Mutation Databases (LSDB): WRAP53
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WRAP53 |
|
Disorders
/ Diseases
for WRAP53 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WRAP53 for disorders About GeneDecksing
OMIM gene information: 612661
OMIM disorders: --
UniProtKB/Swiss-Prot: WAP53_HUMAN, Q9BUR4
Defects in WRAP53 are the cause of dyskeratosis congenita autosomal recessive type 3 (DKCB3) [MIM:613988]. Arare multisystem disorder caused by defective telomere maintenance. It is characterized by progressive bone marrowfailure, and the clinical triad of reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Commonbut variable features include premature graying, aplastic anemia, low platelets, osteoporosis, pulmonary fibrosis, andliver fibrosis among others. Early mortality is often associated with bone marrow failure, infections, fatal pulmonarycomplications, or malignancy
11  diseases for WRAP53: About MalaCardsdyskeratosis congenita autosomal recessive dyskeratosis congenita dyskeratosis aplastic anemia
leukoplakia anemia pulmonary disease osteoporosis
breast cancer malaria neuronitis
1 disease from the University of Copenhagen DISEASES database for WRAP53:Dyskeratosis congenita Human Genome Epidemiology (HuGE) Navigator: WRAP53 (0 documents)
Export disorders for WRAP53 gene to outside databases
|
Publications
for WRAP53 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WRAP53 gene, integrated from 9 sources (see all 36):
(articles sorted by number of sources associating them with WRAP53) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis. (PubMed id 19179534)1, 2, 3 Venteicher A.S.... Artandi S.E. (2009)
- Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage. (PubMed id 19250907)1, 2, 3 Mahmoudi S....Farnebo M. (2009)
- Anthracyclines induce the accumulation of mutant p53 through E2F1-dependent and -independent mechanisms. (PubMed id 21441950)1, 3 Bug M. and Dobbelstein M. (2011)
- Disruption of telomerase trafficking by TCAB1 mutatio n causes dyskeratosis congenita. (PubMed id 21205863)1, 2 Zhong F....Artandi S.E. (2011)
- The p53 tumor suppressor: a master regulator of diver se cellular processes and therapeutic target in cancer. (PubMed id 20494116)1, 3 Farnebo M....Wiman K.G. (2010)
- Wrap53, a novel regulator of p53. (PubMed id 19571673)1, 3 Farnebo M. (2009)
- TCAB1: driving telomerase to Cajal bodies. (PubMed id 19342896)1, 3 Venteicher A.S. and Artandi S.E. (2009)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
|
External Searches for WRAP53 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WRAP53 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WRAP53 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WRAP53 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WRAP53 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WRAP53 gene:
Search GeneIP for patents involving WRAP53
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WRAP53 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WRAP53 |
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