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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WNT9B Gene

protein-coding   GIFtS: 60
GCID: GC17P044910

wingless-type MMTV integration site family, member 9B

(Previous names: wingless-type MMTV integration site family, member 15 )
(Previous symbol: WNT15)
 Explore 10 diseases affiliated with
WNT9B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for WNT9B    

Aliases
for WNT9B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Wingless-Type MMTV Integration Site Family, Member 9B1 2     Protein Wnt-14b2 3
WNT151 2 3 5     Protein Wnt-9b2
WNT14B1 2 3     Protein Wnt-153
Wingless-Type MMTV Integration Site Family, Member 151 2     

External Ids:    HGNC: 127791   Entrez Gene: 74842   Ensembl: ENSG000001589557   OMIM: 6028645   UniProtKB: O149053   

Export aliases for WNT9B gene to outside databases

Previous GC identifers: GC17P047327 GC17P045271 GC17P045403 GC17P042283 GC17P040307


Summaries
for WNT9B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for WNT9B:
The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have
been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and
patterning during embryogenesis. This gene is a member of the WNT gene family. Study of its expression in the
teratocarcinoma cell line NT2 suggests that it may be implicated in the early process of neuronal differentiation of
NT2 cells induced by retinoic acid. This gene is clustered with WNT3, another family member, in the chromosome 17q21
region. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: WNT9B_HUMAN, O14905
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein.
May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over
only few cell diameters (By similarity)




Genomic Views
for WNT9B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WNT9B gene promoter:
         Max1   TBP   GR   p53   NF-kappaB   POU2F1   POU2F1a   GR-alpha   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WNT9B promoter sequence
   Search SABiosciences Chromatin IP Primers for WNT9B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WNT9B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21

WNT9B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT9B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P044910:  view genomic region     (about GC identifiers)

Start:
 44,910,567 bp from pter      End:
 44,964,096 bp from pter
Size:
 53,530 bases      Orientation:
 plus strand

Proteins
for WNT9B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: WNT9B_HUMAN, O14905 (See protein sequence)
Recommended Name: Protein Wnt-9b precursor  
Size: 357 amino acids; 39001 Da
Subunit: Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and LRP5 or
LRP6. Interacts directly in the complex with LRP6
Subcellular location: Secreted, extracellular space, extracellular matrix
Secondary accessions: Q6UXT4 Q96Q09

Explore the universe of human proteins at neXtProt for WNT9B: NX_O14905

Post-translational modifications:

  • Palmitoylation at Ser-216 is required for efficient binding to frizzled receptors. It is also required for subsequent
    • palmitoylation at Cys-89. Palmitoylation is necessary for proper trafficking to cell surface (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O14905

    • WNT9B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003387.1  
    ENSEMBL proteins: 
     ENSP00000458192   ENSP00000290015   ENSP00000377105  
    Reactome Protein details: O14905
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: WNT9B
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    Novus Biologicals WNT9B Protein
    Novus Biologicals WNT9B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for WNT9B

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS9441749
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IBA--
    GO:0005886plasma membrane IBA--


    WNT9B for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for WNT9B

    Protein Domains /
    Families
    for WNT9B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    WNT9B for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR026535 Wnt9
     IPR005817 Wnt
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry O14905

    ProtoNet protein and cluster: O14905

    1 Blocks protein family: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WNT9B_HUMAN, O14905
    Similarity: Belongs to the Wnt family


    Function
    for WNT9B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: WNT9B_HUMAN, O14905
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein.
    May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over
    only few cell diameters (By similarity)

         Summary:  

    During embryonic development, WNT9B as signaling molecule is secreted from the following cells: Collecting Duct Cells in Renal Collecting Duct System, Ureteric Bud Cells in Ureteric Bud

    It affects the following cells: Loop of Henle Cells in Loop of Henle, Pretubular Aggregate Cells in Pretubular Aggregates

    miRNA
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    hsa-mir-324-3p (MIRT004682)

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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WNT9B
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate WNT9B:
    hsa-miR-612 hsa-miR-4290 hsa-miR-1285 hsa-miR-4287
    SwitchGear 3'UTR luciferase reporter plasmid: WNT9B 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: WNT9B
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664G-protein coupled receptor binding IBA--
    GO:0005102receptor binding ----


    WNT9B for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Wnt9btm1.1Amc for WNT9B
         6 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Wnt9b):
     craniofacial  digestive/alimentary  embryogenesis  mortality/aging  renal/urinary system 
     reproductive system 

    WNT9B for phenotypes           About GeneDecksing


    Pathways & Interactions
    for WNT9B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Basal cell carcinoma
    		Basal cell carcinoma1.00
    		Wnt Pathway0.37
    		Hedgehog signaling pathway0.41
    		Melanogenesis0.32
    2Wnt Signaling Pathway
    		Wnt Signaling Pathway and Pluripotency0.55
    		Wnt signaling pathway0.30
    		Wnt Signaling Pathway0.33
    		Wnt Signaling Pathway NetPath0.22
    3Translation_Non-genomic (rapid) action of Androgen Receptor
    		Translation_Non-genomic (rapid) action of Androgen Receptor1.00
    		Translation Non-genomic (rapid) action of Androgen Receptor0.99
    4Transcription_Androgen Receptor nuclear signaling
    		Transcription_Androgen Receptor nuclear signaling1.00
    		Transcription Androgen Receptor nuclear signaling0.99
    5Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for WNT9B
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    1 R&D Systems Pathway for WNT9B
        Wnt Signaling Pathway


    1 Tocris Bioscience Pathway for WNT9B
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT9B
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    2 BioSystems Pathways for WNT9B 
        Wnt Signaling Pathway and Pluripotency
    Wnt Signaling Pathway NetPath

    4        Reactome Pathways for WNT9B
        Signal Transduction
    Signaling by GPCR
    GPCR ligand binding
    Class B/2 (Secretin family receptors)


    5         Kegg Pathways  (Kegg details for WNT9B):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Melanogenesis
    Pathways in cancer
    Basal cell carcinoma


    WNT9B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WNT9B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/22 Interacting proteins for WNT9B (O149053 ENSP000002900154) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DHHO433233I2D: score=1 
    PTK7Q133083I2D: score=1 
    WNT4P567053I2D: score=1 
    CER1ENSP000003702974STRING: ENSP00000370297
    FZD1ENSP000002879344STRING: ENSP00000287934
    About this table

    Gene Ontology (GO): 5/34 biological process terms (GO ID links to tree view) (see all 34):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001658branching involved in ureteric bud morphogenesis IBA--
    GO:0001701in utero embryonic development IEA--
    GO:0001822kidney development ----
    GO:0001932regulation of protein phosphorylation IEA--
    GO:0003339regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis IBA--


    WNT9B for ontologies           About GeneDecksing



    Drugs & Compounds
    for WNT9B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    WNT9B for compounds           About GeneDecksing

    EMD Millipore small molecules for WNT9B:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WNT9B
    1 Novoseek chemical compound relationship for WNT9B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 34.8 4 11604992 (2), 11786923 (1)

    Search CenterWatch for drugs/clinical trials and news about WNT9B 

    Transcripts
    for WNT9B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for WNT9B gene: 
    NM_003396.1  

    Unigene Cluster for WNT9B:

    Wingless-type MMTV integration site family, member 9B
    Hs.326420  [show with all ESTs]
    Unigene Representative Sequence: AK127268
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000575372 ENST00000290015(uc002ikw.1) ENST00000393461(uc002ikx.1)


    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate WNT9B:
    hsa-miR-612 hsa-miR-4290 hsa-miR-1285 hsa-miR-4287
    SwitchGear 3'UTR luciferase reporter plasmid: WNT9B 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WNT9B (see all 7)
    OriGene shRNA RFP: WNT9B
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB063483.1 AK127268.1 AK127615.1 AY358217.1 BC064534.1 

    5 DOTS entries:

    DT.95204679  DT.99983080  DT.404939  DT.101974831  DT.92014147 

    16 AceView cDNA sequences:

    AK127268 NM_003396 AB063483 AA317825 BX107965 Z43167 AW967102 Z39248 
    AY358217 BX503643 AK127615 BM545100 R12603 R09965 AW023308 BF921697 

    GeneLoc Exon Structure


    Expression
    for WNT9B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WNT9B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    WNT9B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyUreteric BudUreteric Bud CellsKidney
    KidneyRenal Collecting Duct SystemCollecting Duct CellsKidney
    KidneyWolffian DuctWolffian Duct CellsKidney
    HeartAtrioventricular NodeAtrioventricular Node CellsMyocardium
    LiverHepatic MesenchymeMesothelial CellsLiver
    KidneyUreteric BudKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See WNT9B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WNT9B

    SOURCE GeneReport for Unigene cluster: Hs.326420

    UniProtKB/Swiss-Prot: WNT9B_HUMAN, O14905
    Tissue specificity: Moderately expressed in fetal kidney and adult kidney. Also found in brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including WNT9B: 
              Hedgehog Signaling Pathway in human mouse rat
              Primary Cilia in human mouse rat
              WNT Signaling Pathway in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for WNT9B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for WNT9B gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves WNT9B1 wingless-type MMTV integration site family, member more 74.29(n)
    78.29(a)    		   771092  XM_001234393.2  XP_001234394.2 
    lizard
    (Anolis carolinensis)    		 Reptilia WNT9B6
    		 --
    		 76(a)
    		 1 ↔ 1
    		 6(65623132-65627641)
    zebrafish
    (Danio rerio)    		 Actinopterygii wnt9b1 wingless-type MMTV integration site family, member more 68.31(n)
    71.3(a)    		   565677  NM_001137660.1  NP_001131132.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Wnt46
    		 Wnt oncogene analog 4
    		 20(a)
    		 1 → many
    		 2L(7255460-7277168)


    ENSEMBL Gene Tree for WNT9B (if available)
    TreeFam Gene Tree for WNT9B (if available) 

    Paralogs
    for WNT9B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WNT9B gene
    WNT8B2  WNT8A2  WNT9A2  
    16 SIMAP similar genes for WNT9B using alignment to 4 protein entries:     WNT9B_HUMAN (see all proteins):
    WNT9A    WNT4    WNT2B    WNT7B    WNT8B    WNT6
    WNT2    WNT5B    WNT7A    WNT5A    WNT16    WNT8A
    WNT1    WNT11    WNT3    WNT3A

    WNT9B for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for WNT9B
    PGOHUM00000262352 PGOHUM00000262366


    Genomic Variants
    for WNT9B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/505 NCBI SNPs in WNT9B are shown (see all 505)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1133926631,2
    		--40305567(+) TATAAC/TGATCA 1 -- us2k12Minor allele frequency- T:0.04CSA WA 120
    rs573934591,2
    		C,--40305961(+) TCATCT/ATCCAT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs98956901,2
    		C,F,--40306660(+) AACATC/AAGCAG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs785807361,2
    		C,F,--40306822(+) TCCCCC/AGCTTC 1 -- us2k11Minor allele frequency- A:0.08WA 118
    rs580349551,2
    		--40306871(+) AGTCTA/GCGGGC 1 -- us2k10--------
    rs1114743941,2
    		C,--40308588(+) GCCAGG/AGAGAG 1 -- int12Minor allele frequency- A:0.06CSA WA 120
    rs129464081,2
    		H--40308760(+) agtctC/Gtgggc 1 -- int14Minor allele frequency- G:0.00NS EA 416
    rs785659181,2
    		F,--40309012(+) TCTCAA/GTCTGT 1 -- int11Minor allele frequency- G:0.02WA 118
    rs124535391,2
    		H--40309088(+) agtgtC/Ttagca 1 -- int14Minor allele frequency- T:0.00NS EA 416
    rs98897051,2
    		H--40309645(+) CCCTAG/ACTGCT 1 -- int14Minor allele frequency- A:0.00NS EA 414

    HapMap Linkage Disequilibrium report for WNT9B (44910567 - 44964096 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for WNT9B
         2 CNVs: 34570 4038

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    Disorders / Diseases
    for WNT9B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    WNT9B for disorders           About GeneDecksing

    OMIM gene information: 602864    OMIM disorders: --

    10 diseases for WNT9B:    About MalaCards
    mayer-rokitansky-kuster-hauser syndrome    rokitansky-kuster-hauser syndrome    cleft lip/palate    cleft lip
    teratocarcinoma    cleft palate    basal cell carcinoma    neuronitis
    hermaphroditism    carcinoma

    2 diseases from the University of Copenhagen DISEASES database for WNT9B:
    Cleft lip     Cleft palate

    4 Novoseek disease relationships for WNT9B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatic cancer 39.7 1 11713592 (1)
    cancer 10.6 5 11713592 (3), 11604992 (1)
    breast cancer 8.08 1 11713592 (1)
    tumors 0 1 11713592 (1)

    Human Genome Epidemiology (HuGE) Navigator: WNT9B (6 documents)

    Export disorders for WNT9B gene to outside databases

    Publications
    for WNT9B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WNT9B gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with WNT9B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21. (PubMed id 9441749)1, 2, 3 Bergstein I.... Brown A.M.C. (1997)
    2. Molecular cloning and characterization of WNT14B, a novel member of the WNT gene family. (PubMed id 11604992)1, 2, 9 Kirikoshi H.... Katoh M. (2001)
    3. Expression of WNT14 and WNT14B mRNAs in human cancer, up-regulation of WNT14 by IFNgamma and up-regulation of WNT14B by beta-estradiol. (PubMed id 11713592)1, 3, 9 Kirikoshi H....Katoh M. (2001)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Genetically distinct subsets within ANCA-associated va sculitis. (PubMed id 22808956)1 Lyons P.A....Smith K.G. (2012)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1 Jugessur A....Murray J.C. (2010)
    8. Genetic variants in COL2A1, COL11A2, and IRF6 contrib ute risk to nonsyndromic cleft palate. (PubMed id 20672350)1 Nikopensius T....Metspalu A. (2010)
    9. Studies with Wnt genes and nonsyndromic cleft lip and palate. (PubMed id 20890934)1 Menezes R....Vieira A.R. (2010)
    10. Reconstitution of a frizzled8.Wnt3a.LRP6 signaling co mplex reveals multiple Wnt and Dkk1 binding sites on LRP6. (PubMed id 20093360)2 Bourhis E....Hannoush R.N. (2010)

    External Searches for WNT9B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing WNT9B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7484 HGNC: 12779 AceView: WNT9B Ensembl:ENSG00000158955 euGenes: HUgn7484
    ECgene: WNT9B Kegg: 7484 H-InvDB: WNT9B

    Other Databases showing WNT9B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing WNT9B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WNT9B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT9B Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for WNT9B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for WNT9B gene:
    Search GeneIP for patents involving WNT9B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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