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Aliases for WNT9B Gene

Aliases for WNT9B Gene

  • Wnt Family Member 9B 2 3
  • Wingless-Type MMTV Integration Site Family, Member 15 2 3
  • Wingless-Type MMTV Integration Site Family Member 9B 3 5
  • Protein Wnt-14b 3 4
  • WNT14B 3 4
  • WNT15 3 4
  • Wingless-Type MMTV Integration Site Family, Member 9B 2
  • Protein Wnt-15 4

External Ids for WNT9B Gene

Previous HGNC Symbols for WNT9B Gene

  • WNT15

Previous GeneCards Identifiers for WNT9B Gene

  • GC17P047327
  • GC17P045271
  • GC17P045403
  • GC17P042283
  • GC17P044910
  • GC17P040307

Summaries for WNT9B Gene

Entrez Gene Summary for WNT9B Gene

  • The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. Study of its expression in the teratocarcinoma cell line NT2 suggests that it may be implicated in the early process of neuronal differentiation of NT2 cells induced by retinoic acid. This gene is clustered with WNT3, another family member, in the chromosome 17q21 region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for WNT9B Gene

WNT9B (Wnt Family Member 9B) is a Protein Coding gene. Diseases associated with WNT9B include exstrophy of the bladder and mayer-rokitansky-kuster-hauser syndrome. Among its related pathways are Basal cell carcinoma and Hippo signaling pathway. GO annotations related to this gene include receptor binding and frizzled binding. An important paralog of this gene is WNT8A.

UniProtKB/Swiss-Prot for WNT9B Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT9B Gene

Genomics for WNT9B Gene

Regulatory Elements for WNT9B Gene

Enhancers for WNT9B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WNT9B on UCSC Golden Path with GeneCards custom track

Genomic Location for WNT9B Gene

Chromosome:
17
Start:
46,833,201 bp from pter
End:
46,886,775 bp from pter
Size:
53,575 bases
Orientation:
Plus strand

Genomic View for WNT9B Gene

Genes around WNT9B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNT9B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNT9B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT9B Gene

Proteins for WNT9B Gene

  • Protein details for WNT9B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14905-WNT9B_HUMAN
    Recommended name:
    Protein Wnt-9b
    Protein Accession:
    O14905
    Secondary Accessions:
    • Q6UXT4
    • Q96Q09

    Protein attributes for WNT9B Gene

    Size:
    357 amino acids
    Molecular mass:
    39001 Da
    Quaternary structure:
    • Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly in the complex with LRP6.

neXtProt entry for WNT9B Gene

Proteomics data for WNT9B Gene at MOPED

Post-translational modifications for WNT9B Gene

  • Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at Asn 99
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT9B Gene

Antibody Products

No data available for DME Specific Peptides for WNT9B Gene

Domains & Families for WNT9B Gene

Gene Families for WNT9B Gene

Protein Domains for WNT9B Gene

Suggested Antigen Peptide Sequences for WNT9B Gene

Graphical View of Domain Structure for InterPro Entry

O14905

UniProtKB/Swiss-Prot:

WNT9B_HUMAN :
  • Belongs to the Wnt family.
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT9B: view

Function for WNT9B Gene

Molecular function for WNT9B Gene

UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).

LifeMap Function Summary for WNT9B Gene

Gene Ontology (GO) - Molecular Function for WNT9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
genes like me logo Genes that share ontologies with WNT9B: view
genes like me logo Genes that share phenotypes with WNT9B: view

Animal Models for WNT9B Gene

MGI Knock Outs for WNT9B:

Animal Model Products

  • Taconic Biosciences Mouse Models for WNT9B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WNT9B Gene

Localization for WNT9B Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT9B Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WNT9B Gene COMPARTMENTS Subcellular localization image for WNT9B gene
Compartment Confidence
extracellular 5
golgi apparatus 2

No data available for Gene Ontology (GO) - Cellular Components for WNT9B Gene

Pathways & Interactions for WNT9B Gene

genes like me logo Genes that share pathways with WNT9B: view

SIGNOR curated interactions for WNT9B Gene

Activates:

Gene Ontology (GO) - Biological Process for WNT9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001658 branching involved in ureteric bud morphogenesis IEA --
GO:0001701 in utero embryonic development IEA --
GO:0001822 kidney development IEA --
GO:0001932 regulation of protein phosphorylation IEA --
GO:0003339 regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis IEA --
genes like me logo Genes that share ontologies with WNT9B: view

Drugs & Compounds for WNT9B Gene

(5) Drugs for WNT9B Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FH535 Pharma Wnt/B-catenin inhibitor 0
IWR-1-endo Pharma Potent Wnt signaling inhibitor 0
Kartogenin Pharma 0
LGK-974 Pharma PORCN inhibitor,potent and specific 0
Wnt-C59 Pharma PORCN inhibitor,highly potent and selective, Highly potent PORCN inhibitor 0

(1) Additional Compounds for WNT9B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) ApexBio Compounds for WNT9B Gene

Compound Action Cas Number
FH535 Wnt/B-catenin inhibitor 108409-83-2
IWR-1-endo Potent Wnt signaling inhibitor 1127442-82-3
Kartogenin 4727-31-5
LGK-974 PORCN inhibitor,potent and specific 1243244-14-5
Wnt-C59 PORCN inhibitor,highly potent and selective 1243243-89-1
genes like me logo Genes that share compounds with WNT9B: view

Transcripts for WNT9B Gene

mRNA/cDNA for WNT9B Gene

Unigene Clusters for WNT9B Gene

Wingless-type MMTV integration site family, member 9B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WNT9B Gene

No ASD Table

Relevant External Links for WNT9B Gene

GeneLoc Exon Structure for
WNT9B
ECgene alternative splicing isoforms for
WNT9B

Expression for WNT9B Gene

mRNA expression in normal human tissues for WNT9B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT9B Gene

This gene is overexpressed in Kidney - Cortex (x9.4).

SOURCE GeneReport for Unigene cluster for WNT9B Gene Hs.326420

mRNA Expression by UniProt/SwissProt for WNT9B Gene

O14905-WNT9B_HUMAN
Tissue specificity: Moderately expressed in fetal kidney and adult kidney. Also found in brain.
genes like me logo Genes that share expression patterns with WNT9B: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for WNT9B Gene

Orthologs for WNT9B Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT9B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WNT9B 35
  • 90.49 (n)
  • 94.89 (a)
WNT9B 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WNT9B 35
  • 91.21 (n)
  • 95.76 (a)
WNT9B 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wnt9b 35
  • 86.53 (n)
  • 93.41 (a)
Wnt9b 16
Wnt9b 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WNT9B 35
  • 99.44 (n)
  • 99.72 (a)
WNT9B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wnt9b 35
  • 87.03 (n)
  • 92.51 (a)
oppossum
(Monodelphis domestica)
Mammalia WNT9B 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 23 (a)
ManyToMany
chicken
(Gallus gallus)
Aves WNT9B 35
  • 75.02 (n)
  • 79.4 (a)
WNT9B 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WNT9B 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wnt9b 35
  • 66.97 (n)
  • 66.06 (a)
zebrafish
(Danio rerio)
Actinopterygii wnt9b 35
  • 68.98 (n)
  • 71.9 (a)
wnt9b 36
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Wnt5 36
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea egl-20 36
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for WNT9B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT9B Gene

ENSEMBL:
Gene Tree for WNT9B (if available)
TreeFam:
Gene Tree for WNT9B (if available)

Paralogs for WNT9B Gene

Paralogs for WNT9B Gene

(16) SIMAP similar genes for WNT9B Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for WNT9B Gene

genes like me logo Genes that share paralogs with WNT9B: view

Variants for WNT9B Gene

Sequence variations from dbSNP and Humsavar for WNT9B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs4968281 - 46,872,756(+) CAGGA(C/T)GGGCC reference, missense
rs731120 -- 46,846,770(+) CAAAG(A/T)GTTCT intron-variant
rs754474 -- 46,876,490(-) ATGTA(C/G)ACCAG reference, synonymous-codon
rs2120202 -- 46,855,941(-) GAGGC(C/T)GAGGT intron-variant
rs881148 -- 46,865,421(+) TGGGG(A/G)ACGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WNT9B Gene

Variant ID Type Subtype PubMed ID
dgv976e1 CNV Complex 17122850
esv2656635 CNV Deletion 23128226
nsv908562 CNV Gain 21882294

Variation tolerance for WNT9B Gene

Residual Variation Intolerance Score: 74.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.08; 50.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WNT9B Gene

HapMap Linkage Disequilibrium report
WNT9B
Human Gene Mutation Database (HGMD)
WNT9B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT9B Gene

Disorders for WNT9B Gene

MalaCards: The human disease database

(3) MalaCards diseases for WNT9B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
exstrophy of the bladder
  • bladder exstrophy
mayer-rokitansky-kuster-hauser syndrome
  • cauv
duodenal disease
  • duodenum disorder
- elite association - COSMIC cancer census association via MalaCards
Search WNT9B in MalaCards View complete list of genes associated with diseases

Relevant External Links for WNT9B

Genetic Association Database (GAD)
WNT9B
Human Genome Epidemiology (HuGE) Navigator
WNT9B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WNT9B
genes like me logo Genes that share disorders with WNT9B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WNT9B Gene

Publications for WNT9B Gene

  1. Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21. (PMID: 9441749) Bergstein I. … Brown A.M.C. (Genomics 1997) 2 3 4 67
  2. Expression of WNT14 and WNT14B mRNAs in human cancer, up-regulation of WNT14 by IFNgamma and up-regulation of WNT14B by beta-estradiol. (PMID: 11713592) Kirikoshi H. … Katoh M. (Int. J. Oncol. 2001) 2 3 23
  3. Molecular cloning and characterization of WNT14B, a novel member of the WNT gene family. (PMID: 11604992) Kirikoshi H. … Katoh M. (Int. J. Oncol. 2001) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Analysis of WNT9B mutations in Chinese women with Mayer-Rokitansky-KA1ster-Hauser syndrome. (PMID: 24268733) Wang M. … Wang S. (Reprod. Biomed. Online 2014) 3

Products for WNT9B Gene

Sources for WNT9B Gene

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