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Aliases for WNT9B Gene

Aliases for WNT9B Gene

  • Wingless-Type MMTV Integration Site Family, Member 9B 2 3
  • WNT15 3 4 6
  • Wingless-Type MMTV Integration Site Family, Member 15 2 3
  • Protein Wnt-14b 3 4
  • WNT14B 3 4
  • Protein Wnt-9b 3
  • Protein Wnt-15 4

External Ids for WNT9B Gene

Previous HGNC Symbols for WNT9B Gene

  • WNT15

Previous GeneCards Identifiers for WNT9B Gene

  • GC17P047327
  • GC17P045271
  • GC17P045403
  • GC17P042283
  • GC17P044910
  • GC17P040307

Summaries for WNT9B Gene

Entrez Gene Summary for WNT9B Gene

  • The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. Study of its expression in the teratocarcinoma cell line NT2 suggests that it may be implicated in the early process of neuronal differentiation of NT2 cells induced by retinoic acid. This gene is clustered with WNT3, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT9B Gene

WNT9B (Wingless-Type MMTV Integration Site Family, Member 9B) is a Protein Coding gene. Diseases associated with WNT9B include teratocarcinoma and mayer-rokitansky-kuster-hauser syndrome. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include frizzled binding. An important paralog of this gene is WNT10B.

UniProtKB/Swiss-Prot for WNT9B Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT9B Gene

Genomics for WNT9B Gene

Regulatory Elements for WNT9B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WNT9B Gene

Start:
46,833,201 bp from pter
End:
46,886,730 bp from pter
Size:
53,530 bases
Orientation:
Plus strand

Genomic View for WNT9B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WNT9B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT9B Gene

Proteins for WNT9B Gene

  • Protein details for WNT9B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14905-WNT9B_HUMAN
    Recommended name:
    Protein Wnt-9b
    Protein Accession:
    O14905
    Secondary Accessions:
    • Q6UXT4
    • Q96Q09

    Protein attributes for WNT9B Gene

    Size:
    357 amino acids
    Molecular mass:
    39001 Da
    Quaternary structure:
    • Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly in the complex with LRP6.

neXtProt entry for WNT9B Gene

Proteomics data for WNT9B Gene at MOPED

Post-translational modifications for WNT9B Gene

  • Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at Asn99
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT9B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for WNT9B Gene

Domains for WNT9B Gene

Gene Families for WNT9B Gene

HGNC:
  • WNT :Wingless-type MMTV integration sites

Protein Domains for WNT9B Gene

Suggested Antigen Peptide Sequences for WNT9B Gene

Graphical View of Domain Structure for InterPro Entry

O14905

UniProtKB/Swiss-Prot:

WNT9B_HUMAN :
  • O14905
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT9B: view

Function for WNT9B Gene

Molecular function for WNT9B Gene

UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).

LifeMap Function Summary for WNT9B Gene

During embryonic development, WNT9B as signaling molecule is secreted from the following cells

Gene Ontology (GO) - Molecular Function for WNT9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding --
GO:0005109 frizzled binding IBA --
genes like me logo Genes that share ontologies with WNT9B: view
genes like me logo Genes that share phenotypes with WNT9B: view

Animal Models for WNT9B Gene

MGI Knock Outs for WNT9B:

Animal Model Products

miRNA for WNT9B Gene

miRTarBase miRNAs that target WNT9B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WNT9B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for WNT9B Gene

Localization for WNT9B Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT9B Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WNT9B Gene COMPARTMENTS Subcellular localization image for WNT9B gene
Compartment Confidence
extracellular 5
plasma membrane 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for WNT9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with WNT9B: view

Pathways for WNT9B Gene

genes like me logo Genes that share pathways with WNT9B: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for WNT9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001658 branching involved in ureteric bud morphogenesis IEA --
GO:0001701 in utero embryonic development IEA --
GO:0001822 kidney development --
GO:0001932 regulation of protein phosphorylation IEA --
GO:0003339 regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis IEA --
genes like me logo Genes that share ontologies with WNT9B: view

Compounds for WNT9B Gene

(5) ApexBio Compounds for WNT9B Gene

Compound Action Cas Number
FH535 Wnt/B-catenin inhibitor [108409-83-2]
IWR-1-endo Potent Wnt signaling inhibitor [1127442-82-3]
Kartogenin [4727-31-5]
LGK-974 "PORCN inhibitor,potent and specific" [1243244-14-5]
Wnt-C59 "PORCN inhibitor,highly potent and selective" [1243243-89-1]

(1) Novoseek inferred chemical compound relationships for WNT9B Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 34.8 3
genes like me logo Genes that share compounds with WNT9B: view

Transcripts for WNT9B Gene

mRNA/cDNA for WNT9B Gene

Unigene Clusters for WNT9B Gene

Wingless-type MMTV integration site family, member 9B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WNT9B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WNT9B Gene

No ASD Table

Relevant External Links for WNT9B Gene

GeneLoc Exon Structure for
WNT9B
ECgene alternative splicing isoforms for
WNT9B

Expression for WNT9B Gene

mRNA expression in normal human tissues for WNT9B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT9B Gene

This gene is overexpressed in Kidney - Cortex (9.4).

SOURCE GeneReport for Unigene cluster for WNT9B Gene Hs.326420

mRNA Expression by UniProt/SwissProt for WNT9B Gene

O14905-WNT9B_HUMAN
Tissue specificity: Moderately expressed in fetal kidney and adult kidney. Also found in brain
genes like me logo Genes that share expressions with WNT9B: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for WNT9B Gene

Orthologs for WNT9B Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT9B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WNT9B 35
  • 90.49 (n)
  • 94.89 (a)
WNT9B 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WNT9B 35
  • 91.21 (n)
  • 95.76 (a)
WNT9B 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wnt9b 35
  • 86.53 (n)
  • 93.41 (a)
Wnt9b 16
Wnt9b 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WNT9B 35
  • 99.44 (n)
  • 99.72 (a)
WNT9B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wnt9b 35
  • 87.03 (n)
  • 92.51 (a)
oppossum
(Monodelphis domestica)
Mammalia WNT9B 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 23 (a)
ManyToMany
chicken
(Gallus gallus)
Aves WNT9B 35
  • 75.02 (n)
  • 79.4 (a)
WNT9B 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WNT9B 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wnt9b 35
  • 66.97 (n)
  • 66.06 (a)
zebrafish
(Danio rerio)
Actinopterygii wnt9b 35
  • 68.98 (n)
  • 71.9 (a)
wnt9b 36
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Wnt5 36
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea egl-20 36
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for WNT9B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT9B Gene

ENSEMBL:
Gene Tree for WNT9B (if available)
TreeFam:
Gene Tree for WNT9B (if available)

Paralogs for WNT9B Gene

Paralogs for WNT9B Gene

Selected SIMAP similar genes for WNT9B Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for WNT9B Gene

genes like me logo Genes that share paralogs with WNT9B: view

Variants for WNT9B Gene

Sequence variations from dbSNP and Humsavar for WNT9B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs754474 -- 46,876,490(-) ATGTA(C/G)ACCAG synonymous-codon, reference
rs881148 -- 46,865,421(+) TGGGG(A/G)ACGAG intron-variant
rs1443311 -- 46,857,605(-) tccta(C/G)acagt intron-variant
rs1530364 -- 46,874,411(+) TGGCA(A/G)GTTTA intron-variant
rs1530365 -- 46,879,346(+) TGTCC(C/G)CTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WNT9B Gene

Variant ID Type Subtype PubMed ID
dgv976e1 CNV Complex 17122850
esv2656635 CNV Deletion 23128226
nsv908562 CNV Gain 21882294

Relevant External Links for WNT9B Gene

HapMap Linkage Disequilibrium report
WNT9B
Human Gene Mutation Database (HGMD)
WNT9B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT9B Gene

Disorders for WNT9B Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for WNT9B Gene in MalaCards »

(2) Diseases for WNT9B Gene including...

(2) University of Copenhagen DISEASES for WNT9B Gene

(4) Novoseek inferred disease relationships for WNT9B Gene

Disease -log(P) Hits PubMed IDs
pancreatic cancer 39.7 1
cancer 10.6 4
breast cancer 8.08 1
tumors 0 1

Relevant External Links for WNT9B

Genetic Association Database (GAD)
WNT9B
Human Genome Epidemiology (HuGE) Navigator
WNT9B
genes like me logo Genes that share disorders with WNT9B: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for WNT9B Gene

Publications for WNT9B Gene

  1. Molecular cloning and characterization of WNT14B, a novel member of the WNT gene family. (PMID: 11604992) Kirikoshi H. … Katoh M. (Int. J. Oncol. 2001) 3 4 23
  2. Expression of WNT14 and WNT14B mRNAs in human cancer, up-regulation of WNT14 by IFNgamma and up-regulation of WNT14B by beta-estradiol. (PMID: 11713592) Kirikoshi H. … Katoh M. (Int. J. Oncol. 2001) 2 3 23
  3. Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21. (PMID: 9441749) Bergstein I. … Brown A.M.C. (Genomics 1997) 2 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate. (PMID: 18413325) Chiquet B.T. … Hecht J.T. (Hum. Mol. Genet. 2008) 3 48

Products for WNT9B Gene

  • Addgene plasmids for WNT9B

Sources for WNT9B Gene

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