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WNT9B Gene

protein-coding   GIFtS: 61
GCID: GC17P044910

Wingless-Type MMTV Integration Site Family, Member 9B

(Previous names: wingless-type MMTV integration site family, member 15)
(Previous symbol: WNT15)
  See WNT9B-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Wingless-Type MMTV Integration Site Family, Member 9B1 2     WNT14B2 3
WNT151 2 3 5     Protein Wnt-9b2
Wingless-Type MMTV Integration Site Family, Member 151 2     Protein Wnt-153
Protein Wnt-14b2 3     

External Ids:    HGNC: 127791   Entrez Gene: 74842   Ensembl: ENSG000001589557   OMIM: 6028645   UniProtKB: O149053   

Export aliases for WNT9B gene to outside databases

Previous GC identifers: GC17P047327 GC17P045271 GC17P045403 GC17P042283 GC17P040307


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WNT9B Gene:
The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins
have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and
patterning during embryogenesis. This gene is a member of the WNT gene family. Study of its expression in the
teratocarcinoma cell line NT2 suggests that it may be implicated in the early process of neuronal differentiation
of NT2 cells induced by retinoic acid. This gene is clustered with WNT3, another family member, in the chromosome
17q21 region. (provided by RefSeq, Jul 2008)

GeneCards Summary for WNT9B Gene:
WNT9B (wingless-type MMTV integration site family, member 9B) is a protein-coding gene. Diseases associated with WNT9B include teratocarcinoma, and mayer-rokitansky-kuster-hauser syndrome. GO annotations related to this gene include frizzled binding. An important paralog of this gene is WNT8B.

UniProtKB/Swiss-Prot: WNT9B_HUMAN, O14905
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental
protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to
signal over only few cell diameters (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NT_187663.1  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WNT9B gene promoter:
         Max1   TBP   GR   p53   NF-kappaB   POU2F1   POU2F1a   GR-alpha   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWNT9B promoter sequence
   Search Chromatin IP Primers for WNT9B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WNT9B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21

WNT9B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT9B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P044910:  view genomic region     (about GC identifiers)

Start:
44,910,567 bp from pter      End:
44,964,096 bp from pter
Size:
53,530 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: WNT9B_HUMAN, O14905 (See protein sequence)
Recommended Name: Protein Wnt-9b precursor  
Size: 357 amino acids; 39001 Da
Subunit: Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and LRP5
or LRP6. Interacts directly in the complex with LRP6
Secondary accessions: Q6UXT4 Q96Q09

Explore the universe of human proteins at neXtProt for WNT9B: NX_O14905

Explore proteomics data for WNT9B at MOPED

Post-translational modifications: 

  • Palmitoylation at Ser-216 is required for efficient binding to frizzled receptors. It is also required for
    subsequent palmitoylation at Cys-89. Palmitoylation is necessary for proper trafficking to cell surface (By
    similarity)1
  • Glycosylation2 at Asn99
  • Modification sites at PhosphoSitePlus

  • See WNT9B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003387.1  
    ENSEMBL proteins: 
     ENSP00000458192   ENSP00000290015   ENSP00000377105  
    Reactome Protein details: O14905

    WNT9B Human Recombinant Protein Products:

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    Novus Biologicals WNT9B Protein
    Novus Biologicals WNT9B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WNT9B

     
    Search eBioscience for Proteins for WNT9B 

     
    antibodies-online proteins for WNT9B (3 products) 

     
    antibodies-online peptides for WNT9B

    WNT9B Antibody Products:

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    WNT9B Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WNT: Wingless-type MMTV integration sites

    3 InterPro protein domains:
     IPR026535 Wnt9
     IPR005817 Wnt
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry O14905

    ProtoNet protein and cluster: O14905

    1 Blocks protein domain: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WNT9B_HUMAN, O14905
    Similarity: Belongs to the Wnt family


    Find genes that share domains with WNT9B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WNT9B_HUMAN, O14905
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental
    protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to
    signal over only few cell diameters (By similarity)

         Summary: 

    During embryonic development, WNT9B as signaling molecule is secreted from the following cells:
                
    Kidney: Ureteric Bud Cells (Renal Collecting Duct System), Collecting Duct Cells (Ureteric Bud)

    It affects the following cells:
    Kidney: Loop of Henle Cells (Loop of Henle), Pretubular Aggregate Cells (Pretubular Aggregates)       to see all 2 cells

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005109frizzled binding IBA--
         
    Find genes that share ontologies with WNT9B           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Wnt9b):
     craniofacial  digestive/alimentary  embryogenesis  mortality/aging  renal/urinary system 
     reproductive system 

    Find genes that share phenotypes with WNT9B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Wnt9btm1.1Amc for WNT9B

       genOway: Develop your customized and physiologically relevant rodent model for WNT9B

    miRNA
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    miRTarBase miRNAs that target WNT9B:
    hsa-mir-324-3p (MIRT004682)

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    4 qRT-PCR Assays for microRNAs that regulate WNT9B:
    hsa-miR-612 hsa-miR-4290 hsa-miR-1285 hsa-miR-4287
    SwitchGear 3'UTR luciferase reporter plasmidWNT9B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat WNT9B

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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WNT9B
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    Addgene plasmids for WNT9B 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT9B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WNT9B_HUMAN, O14905: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane3
    golgi apparatus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IBA--

    Find genes that share ontologies with WNT9B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WNT9B About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathways0.40
    2Wnt Pathway
    Wnt Pathway0.56
    WNT ligand biogenesis and trafficking0.56
    3Basal cell carcinoma
    Basal cell carcinoma0.43
    Melanogenesis0.32
    Hedgehog signaling pathway0.43
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    5Transcription Androgen Receptor nuclear signaling
    Transcription Androgen Receptor nuclear signaling0.49
    Translation Non genomic rapid action of Androgen Receptor0.49


    Find genes that share SuperPaths with WNT9B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for WNT9B
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for WNT9B (see all 7)
        GSK3 Signaling
    Presenilin-Mediated Signaling
    Colorectal Cancer Metastasis
    Human Embryonic Stem Cell Pluripotency
    Nanog in Mammalian ESC Pluripotency

    1 Tocris Bioscience Pathway for WNT9B
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT9B
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    2 BioSystems Pathways for WNT9B
        Wnt Signaling Pathway and Pluripotency
    Wnt Signaling Pathway NetPath

    2 Reactome Pathways for WNT9B
        WNT ligand biogenesis and trafficking
    Class B/2 (Secretin family receptors)


    Selected Kegg Pathways  (Kegg details for WNT9B) (see all 8):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT9B: 
              Hedgehog Signaling Pathway in human mouse rat
              Primary Cilia in human mouse rat
              WNT Signaling Pathway in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for WNT9B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WNT9B (O149053 ENSP000002900154) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTK7Q133083, ENSP000002304194I2D: score=1 STRING: ENSP00000230419
    WNT4P567053, ENSP000002901674I2D: score=1 STRING: ENSP00000290167
    DHHO433233, ENSP000002669914I2D: score=1 STRING: ENSP00000266991
    CER1ENSP000003702974STRING: ENSP00000370297
    FZD1ENSP000002879344STRING: ENSP00000287934
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001658branching involved in ureteric bud morphogenesis IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0001822kidney development ----
    GO:0001932regulation of protein phosphorylation IEA--
    GO:0003339regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis IEA--

    Find genes that share ontologies with WNT9B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WNT9B

    1 Novoseek inferred chemical compound relationship for WNT9B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 34.8 4 11604992 (2), 11786923 (1)



    Find genes that share compounds with WNT9B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WNT9B gene: 
    NM_003396.1  

    Unigene Cluster for WNT9B:

    Wingless-type MMTV integration site family, member 9B
    Hs.326420  [show with all ESTs]
    Unigene Representative Sequence: AK127268
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000575372 ENST00000290015(uc002ikw.1) ENST00000393461(uc002ikx.1)

    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate WNT9B:
    hsa-miR-612 hsa-miR-4290 hsa-miR-1285 hsa-miR-4287
    SwitchGear 3'UTR luciferase reporter plasmidWNT9B 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat WNT9B

    Additional mRNA sequence: 

    AB063483.1 AK127268.1 AK127615.1 AY358217.1 BC064534.1 

    5 DOTS entries:

    DT.95204679  DT.99983080  DT.404939  DT.101974831  DT.92014147 

    16 AceView cDNA sequences:

    AB063483 AK127268 NM_003396 AY358217 BX503643 Z39248 BX107965 AW967102 
    AK127615 AA317825 Z43167 BM545100 R12603 AW023308 R09965 BF921697 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WNT9B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    WNT9B Expression
    About this image


    WNT9B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Kidney (Urinary System)    fully expand to see all 5 entries
             Ureteric Bud Cells Ureteric Bud
             Ureteric Bud
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node
     
     Epithelial Cells
             Collecting Duct Cells Renal Collecting Duct System
    WNT9B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WNT9B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.326420

    UniProtKB/Swiss-Prot: WNT9B_HUMAN, O14905
    Tissue specificity: Moderately expressed in fetal kidney and adult kidney. Also found in brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT9B: 
              Hedgehog Signaling Pathway in human mouse rat
              Primary Cilia in human mouse rat
              WNT Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT9B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WNT9B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wnt9b1 , 5 wingless-type MMTV integration site 9B1, 5 86.53(n)1
    93.41(a)1
      11 (67.47 cM)5
    224121  NM_011719.41  NP_035849.31 
     1037273645 
    chicken
    (Gallus gallus)
    Aves WNT9B1 wingless-type MMTV integration site family, member more 75.02(n)
    79.4(a)
      771092  XM_001234393.3  XP_001234394.2 
    lizard
    (Anolis carolinensis)
    Reptilia WNT9B6
    wingless-type MMTV integration site family, member...
    76(a)
    1 ↔ 1
    6(65623096-65627641)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia wnt9b1 wingless-type MMTV integration site family, member more 66.97(n)
    66.06(a)
      100125200  NM_001103083.1  NP_001096553.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wnt9b1 wingless-type MMTV integration site family, member more 68.98(n)
    71.9(a)
      565677  NM_001137660.2  NP_001131132.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Wnt56
    Wnt oncogene analog 5
    12(a)
    1 → many
    X(18395589-18399436)
    worm
    (Caenorhabditis elegans)
    Secernentea egl-206
    Protein EGL-20 (egl-20) mRNA, complete cds
    27(a)
    many ↔ many
    IV(9812444-9815526) WBGene00001188


    ENSEMBL Gene Tree for WNT9B (if available)
    TreeFam Gene Tree for WNT9B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WNT9B gene
    WNT8B2  WNT10B2  WNT8A2  WNT10A2  WNT9A2  
    16 SIMAP similar genes for WNT9B using alignment to 4 protein entries:     WNT9B_HUMAN (see all proteins):
    WNT9A    WNT4    WNT2B    WNT7B    WNT8B    WNT6
    WNT2    WNT5B    WNT7A    WNT5A    WNT16    WNT8A
    WNT1    WNT11    WNT3    WNT3A

    Find genes that share paralogs with WNT9B           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for WNT9B
    PGOHUM00000262352 PGOHUM00000262366


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WNT9B (see all 638)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs352526471,2
    C--44930730(+) TTTTT-/T/TT  
            
    TTTTT
    1 -- int11NA 2
    rs760306221,2
    F--44932118(-) ACCCGA/GGAGGT 1 -- int11Minor allele frequency- G:0.00NA 2
    rs597995981,2
    C--44932457(+) GTGTT-/AACACA 1 -- int10--------
    rs344917931,2
    C--44935286(+) GTATT-/TTGTTGTT 1 -- cds10--------
    rs761541771,2
    C--44940489(+) CGTGG-/CCACAG 1 -- int10--------
    rs1409986311,2
    C--45941426(+) CCTCCC/TTGAGA 1 -- us2k10--------
    rs1133926631,2
    F--45941478(+) TATAAC/TGATCA 1 -- us2k12Minor allele frequency- T:0.04CSA WA 120
    rs588974751,2
    C,F--45941519(+) TTTAAT/CATCTT 1 -- us2k13Minor allele frequency- C:0.23WA NA EA 358
    rs99137141,2
    C,F,A--45941534(+) TTTTTT/GTTTTG 1 -- us2k13Minor allele frequency- G:0.33NA WA 6
    rs2021945751,2
    --45941534(+) TTTTT-/GTTTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for WNT9B (44910567 - 44964096 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for WNT9B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2656635CNV Deletion23128226
    nsv908562CNV Gain21882294
    dgv976e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WNT9B
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602864    OMIM disorders: --

    2 diseases for WNT9B:    
    About MalaCards
    teratocarcinoma    mayer-rokitansky-kuster-hauser syndrome

    2 diseases from the University of Copenhagen DISEASES database for WNT9B:
    Cleft lip     Cleft palate

    Find genes that share disorders with WNT9B           About GenesLikeMe

    4 Novoseek inferred disease relationships for WNT9B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatic cancer 39.7 1 11713592 (1)
    cancer 10.6 5 11713592 (3), 11604992 (1)
    breast cancer 8.08 1 11713592 (1)
    tumors 0 1 11713592 (1)

    Genetic Association Database (GAD): WNT9B
    Human Genome Epidemiology (HuGE) Navigator: WNT9B (6 documents)

    Export disorders for WNT9B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WNT9B gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with WNT9B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21. (PubMed id 9441749)1, 2, 3 Bergstein I.... Brown A.M.C. (Genomics 1997)
    2. Molecular cloning and characterization of WNT14B, a novel member of the WNT gene family. (PubMed id 11604992)1, 2, 9 Kirikoshi H.... Katoh M. (Int. J. Oncol. 2001)
    3. Expression of WNT14 and WNT14B mRNAs in human cancer, up-regulation of WNT14 by IFNgamma and up-regulation of WNT14B by beta-estradiol. (PubMed id 11713592)1, 3, 9 Kirikoshi H....Katoh M. (Int. J. Oncol. 2001)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    6. Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate. (PubMed id 20672350)1, 4 Nikopensius T....Metspalu A. (Birth Defects Res. Part A Clin. Mol. Teratol. 2010)
    7. Studies with Wnt genes and nonsyndromic cleft lip and palate. (PubMed id 20890934)1, 4 Menezes R....Vieira A.R. (Birth Defects Res. Part A Clin. Mol. Teratol. 2010)
    8. Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate. (PubMed id 18413325)1, 4 Chiquet B.T....Hecht J.T. (Hum. Mol. Genet. 2008)
    9. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    10. Genome-wide RNAi screen reveals a new role of a WNT/CTNNB1 signaling pathway as negative regulator of virus-induced innate immune responses. (PubMed id 23785285)1 Baril M....Lamarre D. (PLoS Pathog. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7484 HGNC: 12779 AceView: WNT9B Ensembl:ENSG00000158955 euGenes: HUgn7484
    ECgene: WNT9B Kegg: 7484 H-InvDB: WNT9B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WNT9B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT9B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WNT9B gene:
    Search GeneIP for patents involving WNT9B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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