Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WNT9B Gene

Aliases for WNT9B Gene

  • Wnt Family Member 9B 2 3 5
  • Wingless-Type MMTV Integration Site Family, Member 15 2 3
  • Protein Wnt-14b 3 4
  • WNT14B 3 4
  • WNT15 3 4
  • Wingless-Type MMTV Integration Site Family, Member 9B 2
  • Wingless-Type MMTV Integration Site Family Member 9B 3
  • Protein Wnt-9b 3
  • Protein Wnt-15 4

External Ids for WNT9B Gene

Previous HGNC Symbols for WNT9B Gene

  • WNT15

Previous GeneCards Identifiers for WNT9B Gene

  • GC17P047327
  • GC17P045271
  • GC17P045403
  • GC17P042283
  • GC17P044910
  • GC17P040307

Summaries for WNT9B Gene

Entrez Gene Summary for WNT9B Gene

  • The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. Study of its expression in the teratocarcinoma cell line NT2 suggests that it may be implicated in the early process of neuronal differentiation of NT2 cells induced by retinoic acid. This gene is clustered with WNT3, another family member, in the chromosome 17q21 region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for WNT9B Gene

WNT9B (Wnt Family Member 9B) is a Protein Coding gene. Diseases associated with WNT9B include Mayer-Rokitansky-Kuster-Hauser Syndrome and Exstrophy Of Bladder. Among its related pathways are Transcription Androgen Receptor nuclear signaling and Endometrial cancer. GO annotations related to this gene include receptor binding and frizzled binding. An important paralog of this gene is WNT9A.

UniProtKB/Swiss-Prot for WNT9B Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).

Additional gene information for WNT9B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT9B Gene

Genomics for WNT9B Gene

Regulatory Elements for WNT9B Gene

Enhancers for WNT9B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H046769 1.7 FANTOM5 Ensembl ENCODE 12.3 -61.5 -61499 4 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 KANSL1-AS1 ENSG00000262539 ARL17A WNT3 ENSG00000253347 WNT9B GOSR2 MRPL45P2 NSFP1 RPS7P11
GH17H046794 1.3 Ensembl ENCODE 12.4 -37.6 -37630 1 HDGF PKNOX1 ATF1 ARID4B ZNF766 ELK1 ATF7 NCOA1 REST SMARCB1 WNT3 WNT9B GOSR2 NSFP1 LOC101929777 RPS7P11
GH17H046922 1.4 ENCODE dbSUPER 10.8 +93.9 93869 9 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B LOC101927060 GOSR2 CDC27 ARL17B MYL4 MRPL45P2 EFCAB13 KANSL1 ARL17A WNT3
GH17H046940 1.2 ENCODE dbSUPER 11.4 +107.8 107793 1 HDGF ARID4B ZNF2 ZNF143 ATF7 PAF1 MXD4 REST MIER2 KAT8 LOC101927060 MYL4 WNT3 WNT9B GOSR2 GC17P046939 PIR50319 PIR52711
GH17H046741 1.1 Ensembl ENCODE 10.5 -90.5 -90483 2 NFIB ZNF473 KLF17 ZNF195 GLIS2 EGR1 ZNF350 FOS CREM SMARCC1 KANSL1-AS1 ARL17B ENSG00000253347 ARL17A LRRC37A17P MRPL45P2 NSFP1 EFCAB13 RPS7P11 WNT3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WNT9B on UCSC Golden Path with GeneCards custom track

Genomic Location for WNT9B Gene

Chromosome:
17
Start:
46,833,201 bp from pter
End:
46,886,775 bp from pter
Size:
53,575 bases
Orientation:
Plus strand

Genomic View for WNT9B Gene

Genes around WNT9B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNT9B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNT9B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT9B Gene

Proteins for WNT9B Gene

  • Protein details for WNT9B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14905-WNT9B_HUMAN
    Recommended name:
    Protein Wnt-9b
    Protein Accession:
    O14905
    Secondary Accessions:
    • Q6UXT4
    • Q96Q09

    Protein attributes for WNT9B Gene

    Size:
    357 amino acids
    Molecular mass:
    39001 Da
    Quaternary structure:
    • Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts directly in the complex with LRP6.

neXtProt entry for WNT9B Gene

Post-translational modifications for WNT9B Gene

  • Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at posLast=9999
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT9B Gene

No data available for DME Specific Peptides for WNT9B Gene

Domains & Families for WNT9B Gene

Gene Families for WNT9B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for WNT9B Gene

Suggested Antigen Peptide Sequences for WNT9B Gene

Graphical View of Domain Structure for InterPro Entry

O14905

UniProtKB/Swiss-Prot:

WNT9B_HUMAN :
  • Belongs to the Wnt family.
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT9B: view

Function for WNT9B Gene

Molecular function for WNT9B Gene

UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).

LifeMap Function Summary for WNT9B Gene

Phenotypes From GWAS Catalog for WNT9B Gene

Gene Ontology (GO) - Molecular Function for WNT9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
GO:0005109 frizzled binding IBA --
GO:0039706 co-receptor binding IEA --
GO:0048018 receptor agonist activity IDA 28733458
genes like me logo Genes that share ontologies with WNT9B: view
genes like me logo Genes that share phenotypes with WNT9B: view

Animal Models for WNT9B Gene

MGI Knock Outs for WNT9B:

Animal Model Products

  • Taconic Biosciences Mouse Models for WNT9B

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for WNT9B
  • Applied Biological Materials Clones for WNT9B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WNT9B Gene

Localization for WNT9B Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT9B Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WNT9B gene
Compartment Confidence
extracellular 5
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for WNT9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with WNT9B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for WNT9B Gene

Pathways & Interactions for WNT9B Gene

genes like me logo Genes that share pathways with WNT9B: view

SIGNOR curated interactions for WNT9B Gene

Activates:

Gene Ontology (GO) - Biological Process for WNT9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001658 branching involved in ureteric bud morphogenesis IEA --
GO:0001701 in utero embryonic development IEA --
GO:0001822 kidney development IEA --
GO:0001932 regulation of protein phosphorylation IEA --
GO:0003339 regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis IEA --
genes like me logo Genes that share ontologies with WNT9B: view

Drugs & Compounds for WNT9B Gene

(9) Drugs for WNT9B Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FH535 Pharma Wnt/B-catenin inhibitor 0
ICG 001 Pharma Wnt/β-catenin pathway inhibitor, Inhibits TCF/beta-catenin-mediated transcription 0
IWP-2 Pharma Wnt production inhibitor,PORCN inhibitor, PORCN inhibitor; inhibits Wnt processing and secretion 0
IWR-1-endo Pharma Potent Wnt signaling inhibitor 0
Kartogenin Pharma 0

(1) Additional Compounds for WNT9B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(9) ApexBio Compounds for WNT9B Gene

Compound Action Cas Number
FH535 Wnt/B-catenin inhibitor 108409-83-2
ICG 001 Wnt/β-catenin pathway inhibitor 847591-62-2
IWP-2 Wnt production inhibitor,PORCN inhibitor 686770-61-6
IWR-1-endo Potent Wnt signaling inhibitor 1127442-82-3
Kartogenin 4727-31-5
KY 02111 WNT signaling inhibitor 1118807-13-8
LGK-974 PORCN inhibitor,potent and specific 1243244-14-5
Salinomycin Polyether ionophore antibiotic;anti-cancer 53003-10-4
Wnt-C59 PORCN inhibitor,highly potent and selective 1243243-89-1
genes like me logo Genes that share compounds with WNT9B: view

Drug Products

Transcripts for WNT9B Gene

mRNA/cDNA for WNT9B Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WNT9B Gene

Wingless-type MMTV integration site family, member 9B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for WNT9B
  • Applied Biological Materials Clones for WNT9B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for WNT9B Gene

No ASD Table

Relevant External Links for WNT9B Gene

GeneLoc Exon Structure for
WNT9B
ECgene alternative splicing isoforms for
WNT9B

Expression for WNT9B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WNT9B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT9B Gene

This gene is overexpressed in Kidney - Cortex (x9.4).

NURSA nuclear receptor signaling pathways regulating expression of WNT9B Gene:

WNT9B

SOURCE GeneReport for Unigene cluster for WNT9B Gene:

Hs.326420

mRNA Expression by UniProt/SwissProt for WNT9B Gene:

O14905-WNT9B_HUMAN
Tissue specificity: Moderately expressed in fetal kidney and adult kidney. Also found in brain.

Evidence on tissue expression from TISSUES for WNT9B Gene

  • Kidney(2.8)
genes like me logo Genes that share expression patterns with WNT9B: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for WNT9B Gene

Orthologs for WNT9B Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT9B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WNT9B 33 34
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia WNT9B 33 34
  • 91.21 (n)
cow
(Bos Taurus)
Mammalia WNT9B 33 34
  • 90.49 (n)
rat
(Rattus norvegicus)
Mammalia Wnt9b 33
  • 87.03 (n)
mouse
(Mus musculus)
Mammalia Wnt9b 33 16 34
  • 86.53 (n)
oppossum
(Monodelphis domestica)
Mammalia WNT9B 34
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 23 (a)
ManyToMany
chicken
(Gallus gallus)
Aves WNT9B 33 34
  • 75.02 (n)
lizard
(Anolis carolinensis)
Reptilia WNT9B 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wnt9b 33
  • 66.97 (n)
zebrafish
(Danio rerio)
Actinopterygii wnt9b 33 34
  • 68.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta Wnt5 34
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea egl-20 34
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
OneToMany
Species where no ortholog for WNT9B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT9B Gene

ENSEMBL:
Gene Tree for WNT9B (if available)
TreeFam:
Gene Tree for WNT9B (if available)

Paralogs for WNT9B Gene

Paralogs for WNT9B Gene

(16) SIMAP similar genes for WNT9B Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for WNT9B Gene

genes like me logo Genes that share paralogs with WNT9B: view

Variants for WNT9B Gene

Sequence variations from dbSNP and Humsavar for WNT9B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000012117 -- 46,843,450(+) AATCA(-/CT)CTGCA intron-variant
rs1000017699 -- 46,837,221(+) CAGGC(A/G)TGAGC intron-variant
rs1000051927 -- 46,863,818(+) CAGTC(A/C)TAGTG intron-variant
rs1000067832 -- 46,851,356(+) GCGCG(C/G)CGCCA intron-variant, upstream-variant-2KB
rs1000095636 -- 46,876,937(+) CCCAA(C/G)CATCC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for WNT9B Gene

Variant ID Type Subtype PubMed ID
esv2656635 CNV deletion 23128226
esv2758692 CNV gain+loss 17122850
nsv1146669 OTHER inversion 26484159
nsv962330 CNV duplication 23825009

Variation tolerance for WNT9B Gene

Residual Variation Intolerance Score: 74.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.08; 50.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WNT9B Gene

Human Gene Mutation Database (HGMD)
WNT9B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WNT9B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT9B Gene

Disorders for WNT9B Gene

MalaCards: The human disease database

(2) MalaCards diseases for WNT9B Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
mayer-rokitansky-kuster-hauser syndrome
  • cauv
exstrophy of bladder
  • bladder exstrophy
- elite association - COSMIC cancer census association via MalaCards
Search WNT9B in MalaCards View complete list of genes associated with diseases

Relevant External Links for WNT9B

Genetic Association Database (GAD)
WNT9B
Human Genome Epidemiology (HuGE) Navigator
WNT9B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WNT9B
genes like me logo Genes that share disorders with WNT9B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WNT9B Gene

Publications for WNT9B Gene

  1. Expression of WNT14 and WNT14B mRNAs in human cancer, up-regulation of WNT14 by IFNgamma and up-regulation of WNT14B by beta-estradiol. (PMID: 11713592) Kirikoshi H … Katoh M (International journal of oncology 2001) 2 3 22 60
  2. Molecular cloning and characterization of WNT14B, a novel member of the WNT gene family. (PMID: 11604992) Kirikoshi H … Katoh M (International journal of oncology 2001) 3 4 22 60
  3. Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21. (PMID: 9441749) Bergstein I … Brown AM (Genomics 1997) 2 3 4 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  5. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 45 60

Products for WNT9B Gene

  • Addgene plasmids for WNT9B

Sources for WNT9B Gene

Content
Loading form....