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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WNT9B Gene

protein-coding   GIFtS: 61
GCID: GC17P044910

Wingless-Type MMTV Integration Site Family, Member 9B

(Previous names: wingless-type MMTV integration site family, member 15)
(Previous symbol: WNT15)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Wingless-Type MMTV Integration Site Family, Member 9B1 2     WNT14B2 3
WNT151 2 3 5     Protein Wnt-9b2
Wingless-Type MMTV Integration Site Family, Member 151 2     Protein Wnt-153
Protein Wnt-14b2 3     

External Ids:    HGNC: 127791   Entrez Gene: 74842   Ensembl: ENSG000001589557   OMIM: 6028645   UniProtKB: O149053   

Export aliases for WNT9B gene to outside databases

Previous GC identifers: GC17P047327 GC17P045271 GC17P045403 GC17P042283 GC17P040307


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WNT9B Gene:
The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins
have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and
patterning during embryogenesis. This gene is a member of the WNT gene family. Study of its expression in the
teratocarcinoma cell line NT2 suggests that it may be implicated in the early process of neuronal differentiation
of NT2 cells induced by retinoic acid. This gene is clustered with WNT3, another family member, in the chromosome
17q21 region. (provided by RefSeq, Jul 2008)

GeneCards Summary for WNT9B Gene: 
WNT9B (wingless-type MMTV integration site family, member 9B) is a protein-coding gene. Diseases associated with WNT9B include teratocarcinoma, and mayer-rokitansky-kuster-hauser syndrome, and among its related super-pathways are Wnt signaling pathway and Basal cell carcinoma. GO annotations related to this gene include G-protein coupled receptor binding. An important paralog of this gene is WNT8B.

UniProtKB/Swiss-Prot: WNT9B_HUMAN, O14905
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental
protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to
signal over only few cell diameters (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WNT9B gene promoter:
         Max1   TBP   GR   p53   NF-kappaB   POU2F1   POU2F1a   GR-alpha   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWNT9B promoter sequence
   Search SABiosciences Chromatin IP Primers for WNT9B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WNT9B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21

WNT9B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT9B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P044910:  view genomic region     (about GC identifiers)

Start:
44,910,567 bp from pter      End:
44,964,096 bp from pter
Size:
53,530 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WNT9B_HUMAN, O14905 (See protein sequence)
Recommended Name: Protein Wnt-9b precursor  
Size: 357 amino acids; 39001 Da
Subunit: Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and LRP5
or LRP6. Interacts directly in the complex with LRP6
Subcellular location: Secreted, extracellular space, extracellular matrix
Secondary accessions: Q6UXT4 Q96Q09

Explore the universe of human proteins at neXtProt for WNT9B: NX_O14905

Explore proteomics data for WNT9B at MOPED 

Post-translational modifications:

  • UniProtKB: Palmitoylation at Ser-216 is required for efficient binding to frizzled receptors. It is also required for
    subsequent palmitoylation at Cys-89. Palmitoylation is necessary for proper trafficking to cell surface (By
    similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O14905

  • WNT9B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WNT9B Protein Expression
    REFSEQ proteins: NP_003387.1  
    ENSEMBL proteins: 
     ENSP00000458192   ENSP00000290015   ENSP00000377105  
    Reactome Protein details: O14905
    Human Recombinant Protein Products for WNT9B: 
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    Novus Biologicals WNT9B Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WNT9B 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IBA--

    WNT9B for ontologies           About GeneDecksing



    WNT9B Antibody Products: 
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    Cloud-Clone Corp. ELISAs for WNT9B 
    Cloud-Clone Corp. CLIAs for WNT9B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WNT: Wingless-type MMTV integration sites

    3 InterPro protein domains:
     IPR026535 Wnt9
     IPR005817 Wnt
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry O14905

    ProtoNet protein and cluster: O14905

    1 Blocks protein domain: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WNT9B_HUMAN, O14905
    Similarity: Belongs to the Wnt family


    WNT9B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WNT9B_HUMAN, O14905
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental
    protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to
    signal over only few cell diameters (By similarity)

         Summary:

    During embryonic development, WNT9B as signaling molecule is secreted from the following cells: Collecting Duct Cells in Renal Collecting Duct System, Ureteric Bud Cells in Ureteric Bud

    It affects the following cells: Loop of Henle Cells in Loop of Henle, Pretubular Aggregate Cells in Pretubular Aggregates

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005109frizzled binding IBA--
         
    WNT9B for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Wnt9b):
     craniofacial  digestive/alimentary  embryogenesis  mortality/aging  renal/urinary system 
     reproductive system 

    WNT9B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Wnt9btm1.1Amc for WNT9B

       inGenious Targeting Laboratory - Custom generated mouse model solutions for WNT9B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for WNT9B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WNT9B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WNT9B 

    miRNA
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    miRTarBase miRNAs that target WNT9B:
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WNT9B
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate WNT9B:
    hsa-miR-612 hsa-miR-4290 hsa-miR-1285 hsa-miR-4287
    SwitchGear 3'UTR luciferase reporter plasmidWNT9B 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT9B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for WNT9B About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathway0.40
    2Basal cell carcinoma
    Hedgehog signaling pathway0.43
    Wnt Pathway0.39
    Basal cell carcinoma0.43
    Melanogenesis0.32
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    4Asparagine N-linked glycosylation
    WNT ligand biogenesis and trafficking0.77
    Signaling by Wnt0.62
    5Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor0.49
    Transcription Androgen Receptor nuclear signaling0.49

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for WNT9B
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    1 R&D Systems Pathway for WNT9B
        Wnt Signaling Pathway


    1 Tocris Bioscience Pathway for WNT9B
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT9B
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    2 BioSystems Pathways for WNT9B
        Wnt Signaling Pathway and Pluripotency
    Wnt Signaling Pathway NetPath

    5/6        Reactome Pathways for WNT9B (see all 6)
        Signaling by Wnt
    Signal Transduction
    Signaling by GPCR
    WNT ligand biogenesis and trafficking
    GPCR ligand binding


    5/8         Kegg Pathways  (Kegg details for WNT9B) (see all 8):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection


    WNT9B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WNT9B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/22 Interacting proteins for WNT9B (O149053 ENSP000002900154) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DHHO433233I2D: score=1 
    PTK7Q133083I2D: score=1 
    WNT4P567053I2D: score=1 
    CER1ENSP000003702974STRING: ENSP00000370297
    FZD1ENSP000002879344STRING: ENSP00000287934
    About this table

    Gene Ontology (GO): 5/30 biological process terms (GO ID links to tree view) (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001658branching involved in ureteric bud morphogenesis IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0001822kidney development ----
    GO:0001932regulation of protein phosphorylation IEA--
    GO:0003339regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis IEA--

    WNT9B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    WNT9B for compounds           About GeneDecksing

    EMD Millipore small molecules for WNT9B:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WNT9B

    1 Novoseek inferred chemical compound relationship for WNT9B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 34.8 4 11604992 (2), 11786923 (1)

    Search CenterWatch for drugs/clinical trials and news about WNT9B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WNT9B gene: 
    NM_003396.1  

    Unigene Cluster for WNT9B:

    Wingless-type MMTV integration site family, member 9B
    Hs.326420  [show with all ESTs]
    Unigene Representative Sequence: AK127268
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000575372 ENST00000290015(uc002ikw.1) ENST00000393461(uc002ikx.1)

    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate WNT9B:
    hsa-miR-612 hsa-miR-4290 hsa-miR-1285 hsa-miR-4287
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    Inhib. RNA
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    Additional mRNA sequence: 

    AB063483.1 AK127268.1 AK127615.1 AY358217.1 BC064534.1 

    5 DOTS entries:

    DT.95204679  DT.99983080  DT.404939  DT.101974831  DT.92014147 

    16 AceView cDNA sequences:

    AB063483 AK127268 NM_003396 AA317825 AW967102 AK127615 BX107965 Z39248 
    Z43167 BX503643 AY358217 BM545100 R12603 R09965 AW023308 BF921697 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WNT9B expression in normal human tissues (normalized intensities)      WNT9B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    WNT9B Expression
    About this image


    WNT9B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Atrioventricular Node Cells Atrioventricular Node
             heart/ventricle   
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Ureteric Bud Cells Ureteric Bud
             Ureteric Bud
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Blood (Cardiovascular System)
             mouse/organ system/cardiovascular system   

    See WNT9B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WNT9B

    SOURCE GeneReport for Unigene cluster: Hs.326420

    UniProtKB/Swiss-Prot: WNT9B_HUMAN, O14905
    Tissue specificity: Moderately expressed in fetal kidney and adult kidney. Also found in brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including WNT9B: 
              Hedgehog Signaling Pathway in human mouse rat
              Primary Cilia in human mouse rat
              WNT Signaling Pathway in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT9B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for WNT9B gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wnt9b1 , 5 wingless-type MMTV integration site 9B1, 5 86.8(n)1
    92.98(a)1
      11 (67.47 cM)5
    224121  NM_011719.41  NP_035849.31 
     1037273645 
    chicken
    (Gallus gallus)
    Aves WNT9B1 wingless-type MMTV integration site family, member more 74.29(n)
    78.29(a)
      771092  XM_001234393.2  XP_001234394.2 
    lizard
    (Anolis carolinensis)
    Reptilia WNT9B6
    Protein Wnt
    76(a)
    1 ↔ 1
    6(65623096-65627641)
    zebrafish
    (Danio rerio)
    Actinopterygii wnt9b1 wingless-type MMTV integration site family, member more 68.31(n)
    71.3(a)
      565677  NM_001137660.1  NP_001131132.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Wnt46
    Wnt oncogene analog 4
    22(a)
    1 → many
    2L(7255460-7277168)


    ENSEMBL Gene Tree for WNT9B (if available)
    TreeFam Gene Tree for WNT9B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WNT9B gene
    WNT8B2  WNT8A2  WNT9A2  
    16 SIMAP similar genes for WNT9B using alignment to 4 protein entries:     WNT9B_HUMAN (see all proteins):
    WNT9A    WNT4    WNT2B    WNT7B    WNT8B    WNT6
    WNT2    WNT5B    WNT7A    WNT5A    WNT16    WNT8A
    WNT1    WNT11    WNT3    WNT3A

    WNT9B for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for WNT9B
    PGOHUM00000262352 PGOHUM00000262366


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/638 SNPs in WNT9B are shown (see all 638)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs352526471,2
    C--44930730(+) TTTTT-/T/TT  
            
    TTTTT
    1 -- int11NA 2
    rs760306221,2
    F--44932118(-) ACCCGA/GGAGGT 1 -- int11Minor allele frequency- G:0.00NA 2
    rs597995981,2
    C--44932457(+) GTGTT-/AACACA 1 -- int10--------
    rs344917931,2
    C--44935286(+) GTATT-/TTGTTGTT 1 -- cds10--------
    rs761541771,2
    C--44940489(+) CGTGG-/CCACAG 1 -- int10--------
    rs1409986311,2
    C--45941426(+) CCTCCC/TTGAGA 1 -- us2k10--------
    rs1133926631,2
    F--45941478(+) TATAAC/TGATCA 1 -- us2k12Minor allele frequency- T:0.04CSA WA 120
    rs588974751,2
    C,F--45941519(+) TTTAAT/CATCTT 1 -- us2k13Minor allele frequency- C:0.23WA NA EA 358
    rs99137141,2
    C,F,A--45941534(+) TTTTTT/GTTTTG 1 -- us2k13Minor allele frequency- G:0.33NA WA 6
    rs2021945751,2
    --45941534(+) TTTTT-/GTTTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for WNT9B (44910567 - 44964096 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for WNT9B:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2656635CNV Deletion23128226
    nsv908562CNV Gain21882294
    dgv976e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602864    OMIM disorders: --

    8 diseases for WNT9B:    About MalaCards
    teratocarcinoma    mayer-rokitansky-kuster-hauser syndrome    cleft lip    cleft palate
    basal cell carcinoma    pancreatic cancer    neuronitis    pancreatitis

    2 diseases from the University of Copenhagen DISEASES database for WNT9B:
    Cleft lip     Cleft palate

    WNT9B for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for WNT9B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatic cancer 39.7 1 11713592 (1)
    cancer 10.6 5 11713592 (3), 11604992 (1)
    breast cancer 8.08 1 11713592 (1)
    tumors 0 1 11713592 (1)

    Genetic Association Database (GAD): WNT9B
    Human Genome Epidemiology (HuGE) Navigator: WNT9B (6 documents)

    Export disorders for WNT9B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WNT9B gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with WNT9B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21. (PubMed id 9441749)1, 2, 3 Bergstein I.... Brown A.M.C. (1997)
    2. Molecular cloning and characterization of WNT14B, a novel member of the WNT gene family. (PubMed id 11604992)1, 2, 9 Kirikoshi H.... Katoh M. (2001)
    3. Expression of WNT14 and WNT14B mRNAs in human cancer, up-regulation of WNT14 by IFNgamma and up-regulation of WNT14B by beta-estradiol. (PubMed id 11713592)1, 3, 9 Kirikoshi H....Katoh M. (2001)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    6. Genetic variants in COL2A1, COL11A2, and IRF6 contrib ute risk to nonsyndromic cleft palate. (PubMed id 20672350)1, 4 Nikopensius T....Metspalu A. (2010)
    7. Studies with Wnt genes and nonsyndromic cleft lip and palate. (PubMed id 20890934)1, 4 Menezes R....Vieira A.R. (2010)
    8. Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate. (PubMed id 18413325)1, 4 Chiquet B.T....Hecht J.T. (2008)
    9. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    10. Genetically distinct subsets within ANCA-associated va sculitis. (PubMed id 22808956)1 Lyons P.A....Smith K.G. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7484 HGNC: 12779 AceView: WNT9B Ensembl:ENSG00000158955 euGenes: HUgn7484
    ECgene: WNT9B Kegg: 7484 H-InvDB: WNT9B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WNT9B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT9B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WNT9B gene:
    Search GeneIP for patents involving WNT9B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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