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Aliases for WNT9A Gene

Aliases for WNT9A Gene

  • Wingless-Type MMTV Integration Site Family, Member 9A 2 3
  • WNT14 3 4 6
  • Wingless-Type MMTV Integration Site Family, Member 14 2 3
  • Protein Wnt-9a 3
  • Protein Wnt-14 4

External Ids for WNT9A Gene

Previous Symbols for WNT9A Gene

  • WNT14

Summaries for WNT9A Gene

Entrez Gene Summary for WNT9A Gene

  • The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is expressed in gastric cancer cell lines. The protein encoded by this gene shows 75% amino acid identity to chicken Wnt14, which has been shown to play a central role in initiating synovial joint formation in the chick limb. This gene is clustered with another family member, WNT3A, in the chromosome 1q42 region. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT9A Gene

WNT9A (Wingless-Type MMTV Integration Site Family, Member 9A) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include extracellular matrix structural constituent and frizzled binding. An important paralog of this gene is WNT10B.

UniProtKB/Swiss-Prot for WNT9A Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).

Gene Wiki entry for WNT9A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT9A Gene

Genomics for WNT9A Gene

Genomic Location for WNT9A Gene

Start:
227,918,656 bp from pter
End:
227,947,975 bp from pter
Size:
29,320 bases
Orientation:
Minus strand

Genomic View for WNT9A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WNT9A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT9A Gene

Regulatory Elements for WNT9A Gene

Proteins for WNT9A Gene

  • Protein details for WNT9A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14904-WNT9A_HUMAN
    Recommended name:
    Protein Wnt-9a
    Protein Accession:
    O14904
    Secondary Accessions:
    • A6NLW2
    • Q2M2J3
    • Q5VWU0
    • Q96S50

    Protein attributes for WNT9A Gene

    Size:
    365 amino acids
    Molecular mass:
    40320 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WNT9A Gene

Proteomics data for WNT9A Gene at MOPED

Post-translational modifications for WNT9A Gene

  • Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at Asn103

Other Protein References for WNT9A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for WNT9A Gene

Domains for WNT9A Gene

Gene Families for WNT9A Gene

HGNC:
  • WNT :Wingless-type MMTV integration sites

Protein Domains for WNT9A Gene

Suggested Antigen Peptide Sequences for WNT9A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14904

UniProtKB/Swiss-Prot:

WNT9A_HUMAN
Family:
  • Belongs to the Wnt family.:
    • O14904
genes like me logo Genes that share domains with WNT9A: view

Function for WNT9A Gene

Molecular function for WNT9A Gene

UniProtKB/Swiss-Prot Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).

Gene Ontology (GO) - Molecular Function for WNT9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding --
GO:0005109 frizzled binding IBA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with WNT9A: view
genes like me logo Genes that share phenotypes with WNT9A: view

Animal Models for WNT9A Gene

MGI Knock Outs for WNT9A:

miRNA for WNT9A Gene

miRTarBase miRNAs that target WNT9A

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for WNT9A Gene

Localization for WNT9A Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT9A Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WNT9A Gene COMPARTMENTS Subcellular localization image for WNT9A gene
Compartment Confidence
extracellular 5
plasma membrane 3
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for WNT9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IBA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with WNT9A: view

Pathways for WNT9A Gene

genes like me logo Genes that share pathways with WNT9A: view

Gene Ontology (GO) - Biological Process for WNT9A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007093 mitotic cell cycle checkpoint IMP 17351820
GO:0007267 cell-cell signaling NAS 9441749
GO:0007275 multicellular organismal development NAS 9441749
GO:0008285 negative regulation of cell proliferation IMP 17351820
GO:0016055 Wnt signaling pathway IBA --
genes like me logo Genes that share ontologies with WNT9A: view

Transcripts for WNT9A Gene

mRNA/cDNA for WNT9A Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WNT9A Gene

Wingless-type MMTV integration site family, member 9A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WNT9A Gene

No ASD Table

Relevant External Links for WNT9A Gene

GeneLoc Exon Structure for
WNT9A
ECgene alternative splicing isoforms for
WNT9A

Expression for WNT9A Gene

mRNA expression in normal human tissues for WNT9A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT9A Gene

This gene is overexpressed in Muscle - Skeletal (7.8) and Colon - Sigmoid (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for WNT9A Gene

SOURCE GeneReport for Unigene cluster for WNT9A Gene Hs.149504

genes like me logo Genes that share expressions with WNT9A: view

No data available for mRNA Expression by UniProt/SwissProt for WNT9A Gene

Orthologs for WNT9A Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT9A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WNT9A 35
  • 99.27 (n)
  • 100 (a)
WNT9A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WNT9A 35
  • 89.97 (n)
  • 97.35 (a)
WNT9A 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WNT9A 35
  • 89.15 (n)
  • 97.01 (a)
WNT9A 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wnt9a 35
  • 89.13 (n)
  • 98.08 (a)
Wnt9a 16
Wnt9a 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WNT9A 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WNT9A 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wnt9a 35
  • 89.42 (n)
  • 97.35 (a)
chicken
(Gallus gallus)
Aves WNT9A 35
  • 77.87 (n)
  • 85.22 (a)
WNT9A 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WNT9A 36
  • 81 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6377 35
zebrafish
(Danio rerio)
Actinopterygii wnt9a 35
  • 73.21 (n)
  • 74.54 (a)
wnt9a 36
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Wnt5 36
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea egl-20 36
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for WNT9A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for WNT9A Gene

ENSEMBL:
Gene Tree for WNT9A (if available)
TreeFam:
Gene Tree for WNT9A (if available)

Paralogs for WNT9A Gene

Paralogs for WNT9A Gene

Selected SIMAP similar genes for WNT9A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with WNT9A: view

Variants for WNT9A Gene

Sequence variations from dbSNP and Humsavar for WNT9A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs587000 -- 227,944,589(-) AGGGA(A/G)TGACC intron-variant
rs590657 -- 227,929,880(-) agaca(G/T)tgcct intron-variant
rs591582 -- 227,929,659(-) accag(G/T)tctca intron-variant
rs592736 -- 227,929,130(-) CTCAC(A/G)GGTTT intron-variant
rs594916 -- 227,945,843(-) CCCCT(C/G/T)TAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WNT9A Gene

Variant ID Type Subtype PubMed ID
esv32853 CNV Gain 17666407
nsv826908 CNV Gain 20364138
nsv873249 CNV Loss 21882294
nsv516409 CNV Loss 19592680
nsv523935 CNV Loss 19592680
nsv873250 CNV Loss 21882294
nsv873251 CNV Loss 21882294
nsv826920 CNV Gain 20364138
nsv826931 CNV Loss 20364138
nsv826942 CNV Gain 20364138

Relevant External Links for WNT9A Gene

HapMap Linkage Disequilibrium report
WNT9A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT9A Gene

Disorders for WNT9A Gene

(6) Novoseek inferred disease relationships for WNT9A Gene

Disease -log(P) Hits PubMed IDs
gastric cancer 49.7 4
pancreatic cancer 49.2 3
breast cancer 19.3 4
cancer 16.1 5
necrosis 2.93 1

Relevant External Links for WNT9A

Genetic Association Database (GAD)
WNT9A
Human Genome Epidemiology (HuGE) Navigator
WNT9A
genes like me logo Genes that share disorders with WNT9A: view

No data available for UniProtKB/Swiss-Prot for WNT9A Gene

Publications for WNT9A Gene

  1. Molecular cloning and characterization of WNT3a and WNT14 clustered in human chromosome 1q42 region. (PMID: 11414706) Saitoh T. … Katoh M. (Biochem. Biophys. Res. Commun. 2001) 3 4 23
  2. Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21. (PMID: 9441749) Bergstein I. … Brown A.M.C. (Genomics 1997) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Comparative genomics on Wnt9a orthologs. (PMID: 15809769) Katoh Y. … Katoh M. (Oncol. Rep. 2005) 3 23

Products for WNT9A Gene

  • Addgene plasmids for WNT9A

Sources for WNT9A Gene

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