Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WNT9A Gene

protein-coding   GIFtS: 59
GCID: GC01M228106

wingless-type MMTV integration site family, member 9A

(Previous names: wingless-type MMTV integration site family, member 14 )
(Previous symbol: WNT14)
 Explore 9 diseases affiliated with
WNT9A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for WNT9A    

Aliases
for WNT9A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Wingless-Type MMTV Integration Site Family, Member 9A1 2
WNT141 2 3 5
Wingless-Type MMTV Integration Site Family, Member 141 2
Protein Wnt-9a2
Protein Wnt-143

External Ids:    HGNC: 127781   Entrez Gene: 74832   Ensembl: ENSG000001438167   OMIM: 6028635   UniProtKB: O149043   

Export aliases for WNT9A gene to outside databases

Previous GC identifers: GC01M223847 GC01M224494 GC01M225083 GC01M224415 GC01M226172 GC01M198625


Summaries
for WNT9A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for WNT9A:
The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have
been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and
patterning during embryogenesis. This gene is a member of the WNT gene family. It is expressed in gastric cancer cell
lines. The protein encoded by this gene shows 75% amino acid identity to chicken Wnt14, which has been shown to play a
central role in initiating synovial joint formation in the chick limb. This gene is clustered with another family
member, WNT3A, in the chromosome 1q42 region. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: WNT9A_HUMAN, O14904
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein.
May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over
only few cell diameters (By similarity)

Gene Wiki entry for WNT9A


Genomic Views
for WNT9A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WNT9A gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   E2F   MyoD   E2F-2   Tal-1beta   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WNT9A promoter sequence
   Search SABiosciences Chromatin IP Primers for WNT9A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WNT9A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42   Ensembl cytogenetic band:  1q42.13   HGNC cytogenetic band: 1q42

WNT9A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT9A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M228106:  view genomic region     (about GC identifiers)

Start:
 228,106,357 bp from pter      End:
 228,135,676 bp from pter
Size:
 29,320 bases      Orientation:
 minus strand

Proteins
for WNT9A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: WNT9A_HUMAN, O14904 (See protein sequence)
Recommended Name: Protein Wnt-9a precursor  
Size: 365 amino acids; 40320 Da
Subcellular location: Secreted, extracellular space, extracellular matrix
Secondary accessions: A6NLW2 Q2M2J3 Q5VWU0 Q96S50

Explore the universe of human proteins at neXtProt for WNT9A: NX_O14904

Post-translational modifications:

  • Palmitoylation at Ser-221 is required for efficient binding to frizzled receptors. It is also required for subsequent
    • palmitoylation at Cys-93. Palmitoylation is necessary for proper trafficking to cell surface (By similarity)1
  • View neXtProt modification sites for NX_O14904

    • WNT9A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003386.1  
    ENSEMBL proteins: 
     ENSP00000272164  
    Reactome Protein details: O14904
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: WNT9A
    OriGene Custom Protein Services for WNT9A 
    GenScript Custom Purified and Recombinant Proteins Services for WNT9A
    Novus Biologicals WNT9A Protein
    Novus Biologicals WNT9A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for WNT9A

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS9441749
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IBA--
    GO:0005886plasma membrane IBA--


    WNT9A for ontologies           About GeneDecksing



    WNT9A Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for WNT9A (Wnt-9a)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for WNT9A 
    GenScript Custom Superior Antibodies Services for WNT9A
    Novus Biologicals WNT9A Antibody
    Search for Antibodies for WNT9A at Abcam  
    Uscn Antibodies for WNT9A
    Search ThermoFisher Antibodies for WNT9A

    Assay Products for WNT9A: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for WNT9A
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for WNT9A

    Protein Domains /
    Families
    for WNT9A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    WNT9A for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR026535 Wnt9
     IPR013303 Wnt9a
     IPR005817 Wnt
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry O14904

    ProtoNet protein and cluster: O14904

    1 Blocks protein family: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WNT9A_HUMAN, O14904
    Similarity: Belongs to the Wnt family


    Function
    for WNT9A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: WNT9A_HUMAN, O14904
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein.
    May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over
    only few cell diameters (By similarity)

         Summary:  

    During embryonic development, WNT9A as signaling molecule is secreted from the following cells: Interzone Cells in Stylopod Synovial Joint, Interzone Cells in Autopod Synovial Joint (see all 3).

    It affects the following cells: Articular Cartilage Cells in Autopod Articular Cartilage, Articular Cartilage Cells in Zeugopod Articular Cartilage (see all 9).

    miRNA
    Products:            		 OriGene 3'-UTR Clone: WNT9A
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WNT9A
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate WNT9A
    SwitchGear 3'UTR luciferase reporter plasmid: WNT9A 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WNT9A (see all 7)
    OriGene shRNA RFP: WNT9A
    OriGene siRNA: WNT9A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WNT9A

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for WNT9A

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WNT9A (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WNT9A
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: WNT9A (NM_003395)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WNT9A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT9A 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for WNT9A
    Search LifeMap BioReagents cell lines for WNT9A

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT9A

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664G-protein coupled receptor binding IBA--
    GO:0005201extracellular matrix structural constituent NAS--


    WNT9A for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for WNT9A:
     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-outs for WNT9A: Wnt9atm1.1Chha Wnt9atm1Lex
         4 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Wnt9a):
     craniofacial  mortality/aging  no phenotypic analysis  skeleton 

    WNT9A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for WNT9A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Basal cell carcinoma
    		Basal cell carcinoma1.00
    		Wnt Pathway0.37
    		Hedgehog signaling pathway0.41
    		Melanogenesis0.32
    2Wnt Signaling Pathway
    		Wnt Signaling Pathway0.33
    		Wnt Signaling Pathway NetPath0.22
    		Wnt signaling pathway0.30
    3Translation_Non-genomic (rapid) action of Androgen Receptor
    		Translation_Non-genomic (rapid) action of Androgen Receptor1.00
    		Translation Non-genomic (rapid) action of Androgen Receptor0.99
    4Transcription_Androgen Receptor nuclear signaling
    		Transcription_Androgen Receptor nuclear signaling1.00
    		Transcription Androgen Receptor nuclear signaling0.99
    5Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for WNT9A
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    1 R&D Systems Pathway for WNT9A
        Wnt Signaling Pathway


    1 Tocris Bioscience Pathway for WNT9A
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT9A
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    1 BioSystems Pathway for WNT9A 
        Wnt Signaling Pathway NetPath

    4        Reactome Pathways for WNT9A
        Signal Transduction
    Signaling by GPCR
    GPCR ligand binding
    Class B/2 (Secretin family receptors)


    5         Kegg Pathways  (Kegg details for WNT9A):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Melanogenesis
    Pathways in cancer
    Basal cell carcinoma


    WNT9A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WNT9A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/20 Interacting proteins for WNT9A (O149043 ENSP000002721644) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTNNB1P352223I2D: score=1 
    IFIT3O148793I2D: score=1 
    WNT4P567053I2D: score=1 
    CER1ENSP000003702974STRING: ENSP00000370297
    FZD1ENSP000002879344STRING: ENSP00000287934
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007267cell-cell signaling NAS9441749
    GO:0007275multicellular organismal development NAS9441749
    GO:0007492endoderm development IBA--
    GO:0008285negative regulation of cell proliferation IMP17351820
    GO:0009798axis specification IBA--


    WNT9A for ontologies           About GeneDecksing



    Drugs & Compounds
    for WNT9A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for WNT9A:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WNT9A
    Search CenterWatch for drugs/clinical trials and news about WNT9A 

    Transcripts
    for WNT9A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for WNT9A gene: 
    NM_003395.2  

    Unigene Cluster for WNT9A:

    Wingless-type MMTV integration site family, member 9A
    Hs.149504  [show with all ESTs]
    Unigene Representative Sequence: AK131041
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000272164(uc001hri.2) ENST00000497852

    miRNA
    Products:             		 OriGene 3'-UTR Clone: WNT9A
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WNT9A
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate WNT9A
    SwitchGear 3'UTR luciferase reporter plasmid: WNT9A 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WNT9A (see all 7)
    OriGene shRNA RFP: WNT9A
    OriGene siRNA: WNT9A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WNT9A
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WNT9A (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WNT9A
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: WNT9A (NM_003395)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WNT9A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT9A 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WNT9A
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WNT9A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WNT9A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WNT9A

    Additional cDNA sequence: 

    AB060283.1 AK131041.1 BC111960.1 BC113431.1 

    2 DOTS entries:

    DT.75100574  DT.95208502 

    18 AceView cDNA sequences:

    AW628030 AI206806 CB850782 AI280246 AI989854 BE220265 AB060283 NM_003395 
    AI784076 BP342331 BF222744 AI914125 AW470939 AK131041 BX118140 AW628384 
    BE218087 AA211273 

    GeneLoc Exon Structure


    Expression
    for WNT9A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WNT9A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CGCTTCTCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    WNT9A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/12 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 12) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbAutopod Synovial JointCentral Intermediate Lamina CellsCartilage
    LimbAutopod Synovial JointInterzone CellsCartilage
    LimbStylopod Synovial JointCentral Intermediate Lamina CellsCartilage
    LimbStylopod Synovial JointInterzone CellsCartilage
    LimbZeugopod Synovial JointCentral Intermediate Lamina CellsCartilage
    LimbZeugopod Synovial JointInterzone CellsCartilage
    CartilageAutopod Articular CartilageArticular Cartilage CellsCartilage
    CartilageStylopod Articular CartilageArticular Cartilage CellsCartilage
    CartilageZeugopod Articular CartilageArticular Cartilage CellsCartilage
    HypoblastHypoblastHypoblast CellsExtraembryonic Tissues
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See WNT9A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WNT9A

    SOURCE GeneReport for Unigene cluster: Hs.149504
        SABiosciences Expression via Pathway-Focused PCR Arrays including WNT9A: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Targets in human mouse rat
              WNT Signaling Pathway in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WNT9A
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WNT9A
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WNT9A
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WNT9A
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT9A

    Orthologs
    for WNT9A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for WNT9A gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves WNT9A1 wingless-type MMTV integration site family, member more 77.87(n)
    85.22(a)    		   395829  NM_204981.1  NP_990312.1 
    lizard
    (Anolis carolinensis)    		 Reptilia WNT9A6
    		 --
    		 81(a)
    		 1 ↔ 1
    		 GL343853.1(113173-126817)
    zebrafish
    (Danio rerio)    		 Actinopterygii wnt9a1 wingless-type MMTV integration site family, member more 73.21(n)
    74.54(a)    		   751644  NM_001045363.1  NP_001038828.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Wnt46
    		 Wnt oncogene analog 4
    		 18(a)
    		 1 → many
    		 2L(7255460-7277168)


    ENSEMBL Gene Tree for WNT9A (if available)
    TreeFam Gene Tree for WNT9A (if available) 

    Paralogs
    for WNT9A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WNT9A gene
    WNT8B2  WNT8A2  WNT9B2  
    17 SIMAP similar genes for WNT9A using alignment to 2 protein entries:     WNT9A_HUMAN (see all proteins):
    WNT9B    WNT4    WNT2B    WNT7B    WNT8B    WNT2
    WNT16    WNT5A    WNT1    WNT7A    WNT8A    WNT5B
    WNT6    WNT11    WNT3    WNT10A    WNT3A

    WNT9A for paralogs           About GeneDecksing



    Genomic Variants
    for WNT9A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/487 NCBI SNPs in WNT9A are shown (see all 487)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1418094101,2
    		--228108687(+) GCCCCA/GACGTG 1 -- ds50010--------
    rs109162441,2
    		C,F,A,H,--228108703(+) AAAGCC/TTCTCA 1 -- ds5001 ese319Minor allele frequency- T:0.25NS EA NA WA 2814
    rs776251741,2
    		C,F,--228108709(+) TCTCAG/TTCCTT 1 -- ds50016Minor allele frequency- T:0.09CSA NS WA NA EA 818
    rs1133995061,2
    		C,F,--228108779(-) TCCCCG/AGGCCT 1 -- ds50011Minor allele frequency- A:0.01NS 428
    rs1816917721,2
    		--228108780(+) GGCCCA/GGGGAC 1 -- ds50010--------
    rs1860387751,2
    		--228108796(+) CCTTGC/TAGGTG 1 -- ds50010--------
    rs1128494051,2
    		C,F,--228108897(-) CACACG/AGTGTG 1 -- ds50012Minor allele frequency- A:0.01NS WA 548
    rs37957671,2
    		C,F,A,--228108932(+) GGCTGG/ACTGGG 1 -- ds500110Minor allele frequency- A:0.38NA CSA NS WA EA 795
    rs1998474561,2
    		--228109070(+) ATGCA-/GGTGTA 1 -- ds50010--------
    rs1912664451,2
    		--228109071(+) TGCAGA/GTGTAG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for WNT9A (228106357 - 228135676 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for WNT9A
         1 CNV: 6812

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WNT9A
    DNA2.0 Custom Variant and Variant Library Synthesis for WNT9A

    Disorders / Diseases
    for WNT9A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    WNT9A for disorders           About GeneDecksing

    OMIM gene information: 602863    OMIM disorders: --

    9 diseases for WNT9A:    About MalaCards
    gastric cancer    basal cell carcinoma    chronic lymphocytic leukemia    lymphocytic leukemia
    syndactyly    hermaphroditism    leukemia    carcinoma
    neuronitis

    6 Novoseek disease relationships for WNT9A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastric cancer 49.7 4 11713592 (2), 11414706 (1), 15809769 (1)
    pancreatic cancer 49.2 3 11713592 (2), 15809769 (1)
    breast cancer 19.3 4 11713592 (3), 15809769 (1)
    cancer 16.1 6 11713592 (3), 11414706 (1), 15809769 (1)
    necrosis 2.93 1 11713592 (1)
    tumors 0 1 11713592 (1)

    Human Genome Epidemiology (HuGE) Navigator: WNT9A (3 documents)

    Export disorders for WNT9A gene to outside databases

    Publications
    for WNT9A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WNT9A gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with WNT9A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21. (PubMed id 9441749)1, 2, 3 Bergstein I.... Brown A.M.C. (1997)
    2. Molecular cloning and characterization of WNT3a and WNT14 clustered in human chromosome 1q42 region. (PubMed id 11414706)1, 2, 9 Saitoh T.... Katoh M. (2001)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Comparative genomics on Wnt9a orthologs. (PubMed id 15809769)1, 9 Katoh Y. and Katoh M. (2005)
    6. Molecular cloning and expression of mouse Wnt14, and structural comparison between mouse Wnt14-Wnt3a gene cluster and human WNT14-WNT3A gene cluster. (PubMed id 11836627)1, 9 Katoh M. (2002)
    7. Expression patterns of Wnt genes during development of an anterior part of the chicken eye. (PubMed id 16258938)1, 9 Fokina V.M. and Frolova E.I. (2006)
    8. Distinct requirements for wnt9a and irf6 in extension and integration mechanisms during zebrafish palate morphogenesis. (PubMed id 23154410)1 Dougherty M....Liao E.C. (2013)
    9. Frameshift mutations of ATBF1, WNT9A, CYLD and PARK2 in gastric and colorectal carcinomas with high microsatellite instability. (PubMed id 20854080)1 An C.H....Lee S.H. (2010)
    10. Association between polymorphisms in Wnt signaling pa thway genes and bone mineral density in postmenopausal Korean women. (PubMed id 20613673)1 Lee D.Y....Kim J.G. (2010)

    External Searches for WNT9A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing WNT9A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7483 HGNC: 12778 AceView: WNT9A Ensembl:ENSG00000143816 euGenes: HUgn7483
    ECgene: WNT9A Kegg: 7483 H-InvDB: WNT9A

    Other Databases showing WNT9A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing WNT9A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WNT9A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT9A Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for WNT9A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for WNT9A gene:
    Search GeneIP for patents involving WNT9A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for WNT9A gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     EMD Millipore small molecules (inhibitor) for WNT9A
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for WNT9A (Wnt-9a)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for WNT9A  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WNT9A   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WNT9A  
     OriGene Protein Over-expression Lysate for WNT9A   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for WNT9A   OriGene 3'-UTR Clone for WNT9A  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WNT9A   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WNT9A  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for WNT9A   OriGene Custom Protein Services for WNT9A  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WNT9A
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WNT9A
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WNT9A
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WNT9A
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WNT9A
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WNT9A
     GenScript Custom Purified and Recombinant Proteins Services for WNT9A GenScript cDNA clones with any tag delivered in your preferred vector for WNT9A
     GenScript Custom Assay Services for WNT9A GenScript Custom Superior Antibodies Services for WNT9A
     GenScript Custom overexpressing Cell Line Services for WNT9A CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in WNT9A promoter
     Search Chromatin IP Primers for WNT9A
     RT2 qPCR Primer Assay in human, mouse, rat WNT9A
     Search GNC Networks for WNT9A
     SABiosciences PCR Arrays including human, mouse, rat WNT9A
     Search Tocris compounds for WNT9A
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     WNT9A antibodies
     WNT9A proteins
     WNT9A lysates
     Search for Antibodies for WNT9A at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for WNT9A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     WNT9A Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for WNT9A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT9A
     SwitchGear 3'UTR luciferase reporter plasmids for WNT9A
     SwitchGear Promoter luciferase reporter plasmids for WNT9A
     Search ThermoFisher Antibodies for WNT9A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT9A
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      WNT9A gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4