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Aliases for WNT8B Gene

Aliases for WNT8B Gene

  • Wnt Family Member 8B 2 3 5
  • Wingless-Type MMTV Integration Site Family, Member 8B 2

External Ids for WNT8B Gene

Previous GeneCards Identifiers for WNT8B Gene

  • GC10P101116
  • GC10P101456
  • GC10P102354
  • GC10P101887
  • GC10P102212
  • GC10P095851

Summaries for WNT8B Gene

Entrez Gene Summary for WNT8B Gene

  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 95%, 86% and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT8B Gene

WNT8B (Wnt Family Member 8B) is a Protein Coding gene. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-independent Wnt/Ca2+ Signaling and Other Non-canonical Wnt Signaling Pathways and Transcription Androgen Receptor nuclear signaling. GO annotations related to this gene include receptor binding and frizzled binding. An important paralog of this gene is WNT8A.

UniProtKB/Swiss-Prot for WNT8B Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.

Gene Wiki entry for WNT8B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT8B Gene

Genomics for WNT8B Gene

Regulatory Elements for WNT8B Gene

Enhancers for WNT8B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G100341 1.5 Ensembl ENCODE dbSUPER 11 -121.0 -121020 2.0 HDGF FOXA2 ARID4B DMAP1 ZNF2 ZNF48 YY1 ZNF143 DEK ZNF263 PKD2L1 EBAG9P1 WNT8B CWF19L1 RNU6-422P ENSG00000231188 BLOC1S2
GH10G100518 1.1 Ensembl ENCODE 11.3 +56.6 56558 1.6 CTCF SAP130 AGO1 ARID4B ZNF48 RAD21 RFX5 ZNF664 GATAD1 POLR2A SEC31B WNT8B BLOC1S2 CWF19L1 GC10M100502 GC10M100501
GH10G100434 1 ENCODE 11.6 -29.1 -29083 0.2 HDGF ATF1 ARNT ARID4B SIN3A ZNF2 ZNF48 SLC30A9 ZNF143 DEK SEC31B SCD ENSG00000231188 WNT8B HIF1AN NDUFB8 ENSG00000255339 ENSG00000273030
GH10G100433 0.9 Ensembl 11.6 -29.3 -29340 0.2 HDGF ATF1 ARNT SIN3A ZNF48 SLC30A9 ZNF143 ZNF263 SP3 REST SCD ENSG00000231188 WNT8B SEC31B HIF1AN NDUFB8 ENSG00000255339 ENSG00000273030
GH10G100497 0.4 dbSUPER 11.4 +34.5 34519 1.1 MAFK WNT8B SCD ENSG00000231188 SEC31B ENSG00000255339 HIF1AN NDUFB8 GC10M100500 LOC105378452
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WNT8B on UCSC Golden Path with GeneCards custom track

Genomic Location for WNT8B Gene

Chromosome:
10
Start:
100,463,041 bp from pter
End:
100,483,744 bp from pter
Size:
20,704 bases
Orientation:
Plus strand

Genomic View for WNT8B Gene

Genes around WNT8B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNT8B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNT8B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT8B Gene

Proteins for WNT8B Gene

  • Protein details for WNT8B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93098-WNT8B_HUMAN
    Recommended name:
    Protein Wnt-8b
    Protein Accession:
    Q93098
    Secondary Accessions:
    • O00771
    • Q5VX55
    • Q8WYK9

    Protein attributes for WNT8B Gene

    Size:
    351 amino acids
    Molecular mass:
    38721 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WNT8B Gene

Post-translational modifications for WNT8B Gene

  • Palmitoleylation is required for efficient binding to frizzled receptors (By similarity). Depalmitoleylation leads to Wnt signaling pathway inhibition (By similarity).
  • Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT8B.
  • Glycosylation at posLast=103103 and Asn259

Other Protein References for WNT8B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WNT8B Gene

Domains & Families for WNT8B Gene

Gene Families for WNT8B Gene

Protein Domains for WNT8B Gene

Suggested Antigen Peptide Sequences for WNT8B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q93098

UniProtKB/Swiss-Prot:

WNT8B_HUMAN :
  • Belongs to the Wnt family.
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT8B: view

Function for WNT8B Gene

Molecular function for WNT8B Gene

GENATLAS Biochemistry:
wingless-type MMTV integration site 8B,member of the WNT family encoding intercellular signaling molecules,expressed in the developing forebrain,Drosophila wingless (Wg) segment polarity gene homolog,modulating cell fate and cell behavior during vertebrate development
UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.

Gene Ontology (GO) - Molecular Function for WNT8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005109 frizzled binding IBA --
genes like me logo Genes that share ontologies with WNT8B: view

Phenotypes for WNT8B Gene

genes like me logo Genes that share phenotypes with WNT8B: view

Animal Models for WNT8B Gene

MGI Knock Outs for WNT8B:

Animal Model Products

  • Taconic Biosciences Mouse Models for WNT8B

CRISPR Products

miRNA for WNT8B Gene

miRTarBase miRNAs that target WNT8B

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for WNT8B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WNT8B Gene

Localization for WNT8B Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT8B Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WNT8B gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for WNT8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with WNT8B: view

Pathways & Interactions for WNT8B Gene

genes like me logo Genes that share pathways with WNT8B: view

SIGNOR curated interactions for WNT8B Gene

Activates:

Gene Ontology (GO) - Biological Process for WNT8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9536085
GO:0007275 multicellular organism development IEA --
GO:0007369 gastrulation ISS 7635061
GO:0007399 nervous system development TAS 9536085
GO:0016055 Wnt signaling pathway TAS --
genes like me logo Genes that share ontologies with WNT8B: view

Drugs & Compounds for WNT8B Gene

No Compound Related Data Available

Transcripts for WNT8B Gene

mRNA/cDNA for WNT8B Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WNT8B Gene

Wingless-type MMTV integration site family, member 8B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for WNT8B

Alternative Splicing Database (ASD) splice patterns (SP) for WNT8B Gene

No ASD Table

Relevant External Links for WNT8B Gene

GeneLoc Exon Structure for
WNT8B
ECgene alternative splicing isoforms for
WNT8B

Expression for WNT8B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WNT8B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT8B Gene

This gene is overexpressed in Testis (x8.3) and Kidney - Cortex (x4.2).

Protein differential expression in normal tissues from HIPED for WNT8B Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WNT8B Gene



Protein tissue co-expression partners for WNT8B Gene

NURSA nuclear receptor signaling pathways regulating expression of WNT8B Gene:

WNT8B

SOURCE GeneReport for Unigene cluster for WNT8B Gene:

Hs.421281

mRNA Expression by UniProt/SwissProt for WNT8B Gene:

Q93098-WNT8B_HUMAN
Tissue specificity: Expression is restricted to the brain, and more specifically to the forebrain.

Evidence on tissue expression from TISSUES for WNT8B Gene

  • Nervous system(4.3)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with WNT8B: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for WNT8B Gene

Orthologs for WNT8B Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT8B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WNT8B 34 35
  • 99.72 (n)
cow
(Bos Taurus)
Mammalia WNT8B 34 35
  • 93.69 (n)
dog
(Canis familiaris)
Mammalia WNT8B 34 35
  • 93.56 (n)
rat
(Rattus norvegicus)
Mammalia Wnt8b 34
  • 91.1 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WNT8B 35
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WNT8B 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wnt8b 34 16 35
  • 89.08 (n)
chicken
(Gallus gallus)
Aves WNT8B 34 35
  • 79.71 (n)
lizard
(Anolis carolinensis)
Reptilia WNT8B 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wnt8b 34
  • 72.38 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xwnt-8b 34
zebrafish
(Danio rerio)
Actinopterygii wnt8b 34 35
  • 75.17 (n)
fruit fly
(Drosophila melanogaster)
Insecta wntD 35
  • 26 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea lin-44 35
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
Species where no ortholog for WNT8B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT8B Gene

ENSEMBL:
Gene Tree for WNT8B (if available)
TreeFam:
Gene Tree for WNT8B (if available)

Paralogs for WNT8B Gene

Paralogs for WNT8B Gene

(16) SIMAP similar genes for WNT8B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WNT8B: view

Variants for WNT8B Gene

Sequence variations from dbSNP and Humsavar for WNT8B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_036288 A colorectal cancer sample
rs1000191400 -- 100,464,335(+) TTAAT(G/T)GGCAT intron-variant
rs1000287935 -- 100,463,862(+) ATAAC(A/G)TATAT intron-variant, nc-transcript-variant
rs1000383006 -- 100,475,067(+) GAAAC(C/G)CCATC intron-variant
rs1000623963 -- 100,462,093(+) GGCCT(A/G)GGTGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for WNT8B Gene

Variant ID Type Subtype PubMed ID
esv2759779 CNV gain+loss 17122850
esv34217 CNV gain 17911159
esv3624362 CNV gain 21293372
nsv818783 CNV gain 17921354
nsv819434 CNV loss 19587683
nsv831962 CNV gain 17160897
nsv831963 CNV loss 17160897
nsv8723 CNV gain 18304495

Variation tolerance for WNT8B Gene

Residual Variation Intolerance Score: 35.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.95; 79.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WNT8B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WNT8B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT8B Gene

Disorders for WNT8B Gene

Relevant External Links for WNT8B

Genetic Association Database (GAD)
WNT8B
Human Genome Epidemiology (HuGE) Navigator
WNT8B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WNT8B

No disorders were found for WNT8B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WNT8B Gene

Publications for WNT8B Gene

  1. Isolation and characterization of WNT8B, a novel human Wnt gene that maps to 10q24. (PMID: 8661156) Lako M. … Lindsay S. (Genomics 1996) 2 3 4 22 64
  2. Up-regulation of WNT8B mRNA in human gastric cancer. (PMID: 11788899) Saitoh T. … Katoh M. (Int. J. Oncol. 2002) 3 4 22 64
  3. A novel mammalian Wnt gene, WNT8B, shows brain-restricted expression in early development, with sharply delimited expression boundaries in the developing forebrain. (PMID: 9536085) Lako M. … Strachan T. (Hum. Mol. Genet. 1998) 3 4 22 64
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64

Products for WNT8B Gene

  • Addgene plasmids for WNT8B

Sources for WNT8B Gene

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