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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WNT8B Gene

protein-coding   GIFtS: 59
GCID: GC10P102212

wingless-type MMTV integration site family, member 8B
 Explore 8 diseases affiliated with
WNT8B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for WNT8B    

Aliases
for WNT8B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Wingless-Type MMTV Integration Site Family, Member 8B1 2
Protein Wnt-8b2

External Ids:    HGNC: 127891   Entrez Gene: 74792   Ensembl: ENSG000000752907   OMIM: 6013965   UniProtKB: Q930983   

Export aliases for WNT8B gene to outside databases

Previous GC identifers: GC10P101116 GC10P101456 GC10P102354 GC10P101887 GC10P095851


Summaries
for WNT8B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for WNT8B:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins
have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and
patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 95%,
86% and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression
patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal
location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: WNT8B_HUMAN, Q93098
Function: Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the
development and differentiation of certain forebrain structures, notably the hippocampus

Gene Wiki entry for WNT8B


Genomic Views
for WNT8B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WNT8B gene promoter:
         Oct-B1   POU2F2 (Oct-2.1)   oct-B3   oct-B2   GATA-3   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WNT8B promoter sequence
   Search SABiosciences Chromatin IP Primers for WNT8B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WNT8B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24   Ensembl cytogenetic band:  10q24.31   HGNC cytogenetic band: 10q24

WNT8B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT8B gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P102212:  view genomic region     (about GC identifiers)

Start:
 102,222,798 bp from pter      End:
 102,243,501 bp from pter
Size:
 20,704 bases      Orientation:
 plus strand

Proteins
for WNT8B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: WNT8B_HUMAN, Q93098 (See protein sequence)
Recommended Name: Protein Wnt-8b precursor  
Size: 351 amino acids; 38721 Da
Subcellular location: Secreted, extracellular space, extracellular matrix
Secondary accessions: O00771 Q5VX55 Q8WYK9

Explore the universe of human proteins at neXtProt for WNT8B: NX_Q93098

WNT8B Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_003384.2  
ENSEMBL proteins: 
 ENSP00000340677  
Reactome Protein details: Q93098
Human Recombinant Protein Products: 
Browse Purified and Recombinant Proteins at EMD Millipore
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OriGene Protein Over-expression Lysate: WNT8B
OriGene Custom Protein Services for WNT8B 
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Novus Biologicals WNT8B Lysate
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins
Uscn Proteins for WNT8B

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005578proteinaceous extracellular matrix IEA--
GO:0005615extracellular space IBA--
GO:0005886plasma membrane IBA--


WNT8B for ontologies           About GeneDecksing



WNT8B Antibody Products: 
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Uscn Antibodies for WNT8B
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Uscn ELISAs and CLIAs for WNT8B

Protein Domains /
Families
for WNT8B gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
WNT8B for domains           About GeneDecksing

3 InterPro domains/families:
 IPR013301 Wnt8
 IPR005817 Wnt
 IPR018161 Wnt_CS

Graphical View of Domain Structure for InterPro Entry Q93098

ProtoNet protein and cluster: Q93098

1 Blocks protein family: IPB005816 Secreted growth factor Wnt protein

UniProtKB/Swiss-Prot: WNT8B_HUMAN, Q93098
Similarity: Belongs to the Wnt family


Function
for WNT8B gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:

     UniProtKB/Swiss-Prot: WNT8B_HUMAN, Q93098
Function: Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the
development and differentiation of certain forebrain structures, notably the hippocampus

     Genatlas biochemistry entry for WNT8B:
wingless-type MMTV integration site 8B,member of the WNT family encoding intercellular signaling molecules,expressed in
the developing forebrain,Drosophila wingless (Wg) segment polarity gene homolog,modulating cell fate and cell behavior
during vertebrate development

miRNA
Products:    		 OriGene 3'-UTR Clone: WNT8B
Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WNT8B
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate WNT8B
SwitchGear 3'UTR luciferase reporter plasmid: WNT8B 3' UTR sequence
Inhib. RNA
Products:    		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WNT8B (see all 7)
OriGene shRNA RFP: WNT8B
OriGene siRNA: WNT8B
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WNT8B

Gene Editing
Products:		DNA2.0 Custom Protein Engineering Service for WNT8B

Clone
Products:     		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WNT8B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WNT8B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: WNT8B (NM_003393)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for WNT8B
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT8B 

Cell Line
Products:     		GenScript Custom overexpressing Cell Line Services for WNT8B
Search LifeMap BioReagents cell lines for WNT8B

In Situ Assay
Products:   
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT8B

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001664G-protein coupled receptor binding IBA--


WNT8B for ontologies           About GeneDecksing


Animal Models:
     Mouse knock-out Wnt8btm1Jmas for WNT8B
     1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Wnt8b):
 nervous system 

WNT8B for phenotypes           About GeneDecksing


Pathways & Interactions
for WNT8B gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Basal cell carcinoma
Basal cell carcinoma1.00
Wnt Pathway0.37
Hedgehog signaling pathway0.41
Melanogenesis0.32
2Translation_Non-genomic (rapid) action of Androgen Receptor
Translation_Non-genomic (rapid) action of Androgen Receptor1.00
Translation Non-genomic (rapid) action of Androgen Receptor0.99
3Transcription_Androgen Receptor nuclear signaling
Transcription_Androgen Receptor nuclear signaling1.00
Transcription Androgen Receptor nuclear signaling0.99
4Nanog in Mammalian ESC Pluripotency
Nanog in Mammalian ESC Pluripotency1.00
GSK3 Signaling0.61
5Human Embryonic Stem Cell Pluripotency
Human Embryonic Stem Cell Pluripotency1.00
Factors Promoting Cardiogenesis in Vertebrates0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for WNT8B
    Transcription Androgen Receptor nuclear signaling
Translation Non-genomic (rapid) action of Androgen Receptor

1 R&D Systems Pathway for WNT8B
    Wnt Signaling Pathway

5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for WNT8B (see all 8)
    GSK3 Signaling
Factors Promoting Cardiogenesis in Vertebrates
Presenilin-Mediated Signaling
Human Embryonic Stem Cell Pluripotency
Colorectal Cancer Metastasis

1 Tocris Bioscience Pathway for WNT8B
    Wnt Pathway

2 GeneGo (Thomson Reuters) Pathways for WNT8B
    Transcription Androgen Receptor nuclear signaling
Translation Non-genomic (rapid) action of Androgen Receptor

4        Reactome Pathways for WNT8B
    Signal Transduction
Signaling by GPCR
GPCR ligand binding
Class B/2 (Secretin family receptors)


5         Kegg Pathways  (Kegg details for WNT8B):
    Wnt signaling pathway
Hedgehog signaling pathway
Melanogenesis
Pathways in cancer
Basal cell carcinoma


WNT8B for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WNT8B

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

5/17 Interacting proteins for WNT8B (ENSP000003406774) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
InteractantInteraction Details
GeneCardExternal ID(s)
CER1ENSP000003702974STRING: ENSP00000370297
FZD1ENSP000002879344STRING: ENSP00000287934
FZD10ENSP000002290304STRING: ENSP00000229030
FZD2ENSP000003239014STRING: ENSP00000323901
FZD3ENSP000002400934STRING: ENSP00000240093
About this table

Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001654eye development IBA--
GO:0007165signal transduction TAS9536085
GO:0007369gastrulation ISS7635061
GO:0007399nervous system development TAS9536085
GO:0007492endoderm development IBA--


WNT8B for ontologies           About GeneDecksing



Drugs & Compounds
for WNT8B gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
EMD Millipore small molecules for WNT8B:
Small Molecule - inhibitor
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for WNT8B
Search CenterWatch for drugs/clinical trials and news about WNT8B 

Transcripts
for WNT8B gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for WNT8B gene: 
NM_003393.3  

Unigene Cluster for WNT8B:

Wingless-type MMTV integration site family, member 8B
Hs.421281  [show with all ESTs]
Unigene Representative Sequence: Y11094
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000343737(uc001krb.3)

miRNA
Products:     		 OriGene 3'-UTR Clone: WNT8B
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WNT8B
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate WNT8B
SwitchGear 3'UTR luciferase reporter plasmid: WNT8B 3' UTR sequence
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WNT8B (see all 7)
OriGene shRNA RFP: WNT8B
OriGene siRNA: WNT8B
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WNT8B
Clone
Products:     		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WNT8B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WNT8B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: WNT8B (NM_003393)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for WNT8B
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT8B 
Primer
Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WNT8B
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WNT8B
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WNT8B
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WNT8B

Additional cDNA sequence: 

AB073637.1 X91940.1 Y11094.1 

1 DOTS entry:

DT.91705411 

7 AceView cDNA sequences:

AB073637 BF732616 X91940 BF354999 Y11094 NM_003393 BX279669 

GeneLoc Exon Structure


Expression
for WNT8B gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

WNT8B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGGACTTT

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

WNT8B expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
6 LifeMap In Vivo Development Anatomical Compartments/Cells 
Tissue Anatomical Compartment CellCategory (developmental path)
BrainSubstantia Nigra pars CompactaAdult Dopaminergic NeuronsDopaminergic neurons
BrainSubstantia Nigra pars CompactaDopaminergic Progenitor CellsDopaminergic neurons
BrainSubstantia Nigra pars CompactaEmbryonic Dopaminergic NeuronsDopaminergic neurons
BrainVentral Tegmental AreaAdult Dopaminergic NeuronsDopaminergic neurons
BrainVentral Tegmental AreaDopaminergic Progenitor CellsDopaminergic neurons
BrainVentral Tegmental AreaEmbryonic Dopaminergic NeuronsDopaminergic neurons
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See WNT8B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WNT8B

SOURCE GeneReport for Unigene cluster: Hs.421281

UniProtKB/Swiss-Prot: WNT8B_HUMAN, Q93098
Tissue specificity: Expression is restricted to the brain, and more specifically to the forebrain

    SABiosciences Expression via Pathway-Focused PCR Arrays including WNT8B: 
          Hedgehog Signaling Pathway in human mouse rat
          WNT Signaling Pathway in human mouse rat

Primer
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QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WNT8B
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WNT8B
In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT8B

Orthologs
for WNT8B gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of animals.

Orthologs for WNT8B gene from 6/18 species (see all 18)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
chicken
(Gallus gallus)		 Aves WNT8B1 wingless-type MMTV integration site family, member more 81.24(n)
91.74(a)		   428953  XM_426508.2  XP_426508.2 
lizard
(Anolis carolinensis)		 Reptilia WNT8B6
 --
 89(a)
 1 ↔ 1
 GL343388.1(210545-223656)
African clawed frog
(Xenopus laevis)		 Amphibia Xwnt-8b2 Xwnt-8b protein 78.21(n)    U22173.1 
zebrafish
(Danio rerio)		 Actinopterygii wnt8b2 wnt8b 82.19(n)   30144  U10870.1 
fruit fly
(Drosophila melanogaster)		 Insecta wntD6
 wnt inhibitor of Dorsal
 23(a)
 possible ortholog
 3R(9117774-9118920)
worm
(Caenorhabditis elegans)		 Secernentea lin-446
 Abnormal cell lineage protein 44
 23(a)
 possible ortholog
 I(4126058-4129309)


ENSEMBL Gene Tree for WNT8B (if available)
TreeFam Gene Tree for WNT8B (if available) 

Paralogs
for WNT8B gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for WNT8B gene
WNT8A2  WNT9B2  WNT9A2  
17 SIMAP similar genes for WNT8B using alignment to 1 protein entry:     WNT8B_HUMAN:
WNT8A    WNT2    WNT4    WNT5B    WNT2B    WNT5A
WNT9A    WNT7B    WNT9B    WNT1    WNT16    WNT11
WNT7A    WNT3    WNT3A    WNT6    WNT10B

WNT8B for paralogs           About GeneDecksing



Genomic Variants
for WNT8B gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/373 NCBI SNPs in WNT8B are shown (see all 373)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 10 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs1926215501,2
--102220935(+) TGCCCA/GAATCT 1 -- us2k10--------
rs1505154431,2
--102220950(+) TACCTC/TCCAAT 1 -- us2k10--------
rs1855746111,2
--102220967(+) TTGCAC/TCCCTT 1 -- us2k10--------
rs49194641,2
C,F,A,--102221195(+) CAAATA/GAAGAC 1 -- us2k111Minor allele frequency- G:0.16NA CSA WA EA 510
rs1383096331,2
--102221217(+) GATTCC/TATGTG 1 -- us2k10--------
rs1904803861,2
--102221271(+) TAAATC/TGTCTG 1 -- us2k10--------
rs1496496591,2
--102221375(+) TAAAAC/GAAAAG 1 -- us2k10--------
rs1930884741,2
--102221380(+) GAAAAG/TAACAA 1 -- us2k10--------
rs1847204021,2
--102221401(+) CTCAGA/GGAGAC 1 -- us2k10--------
rs742326761,2
C,F,--102221424(+) GATGCA/GGATGC 1 -- us2k111Minor allele frequency- G:0.19WA NA CSA EA 374

HapMap Linkage Disequilibrium report for WNT8B (102222798 - 102243501 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for WNT8B
     5 CNVs: 8665 9645 30514 2888 3818
     1 Indel: 58416

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WNT8B
DNA2.0 Custom Variant and Variant Library Synthesis for WNT8B

Disorders / Diseases
for WNT8B gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
WNT8B for disorders           About GeneDecksing

OMIM gene information: 601396    OMIM disorders: --

8 diseases for WNT8B:    About MalaCards
basal cell carcinoma    polydactyly    hermaphroditism    alzheimer's disease
gastric cancer    colorectal cancer    carcinoma    neuronitis

Human Genome Epidemiology (HuGE) Navigator: WNT8B (3 documents)

Export disorders for WNT8B gene to outside databases

Publications
for WNT8B gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for WNT8B gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with WNT8B)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Isolation and characterization of WNT8B, a novel human Wnt gene that maps to 10q24. (PubMed id 8661156)1, 2, 3, 9 Lako M.... Lindsay S. (1996)
  2. Up-regulation of WNT8B mRNA in human gastric cancer. (PubMed id 11788899)1, 2, 9 Saitoh T.... Katoh M. (2002)
  3. A novel mammalian Wnt gene, WNT8B, shows brain-restricted expression in early development, with sharply delimited expression boundaries in the developing forebrain. (PubMed id 9536085)1, 2, 9 Lako M.... Strachan T. (1998)
  4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
  5. [Mutation and expression of WNT8b gene and SHH gene i n Hirschprung disease]. (PubMed id 20972907)1 Gao H....Wang W.L. (2010)
  6. Conserved POU/OCT- and GATA-binding sites in 5'-flanking promoter region of mammalian WNT8B orthologs. (PubMed id 17390031)1 Katoh M. and Katoh M. (2007)
  7. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
  8. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
  9. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
  10. Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines: up-regulation of WNT8B mRNA by beta-estradiol in MCF-7 cells, and down-regulation of WNT8A and WNT8B mRNAs by retinoic acid in NT2 cells. (PubMed id 11956596)1 Saitoh T....Katoh M. (2002)

External Searches for WNT8B gene

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Genome Databases showing WNT8B gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7479 HGNC: 12789 AceView: WNT8B Ensembl:ENSG00000075290 euGenes: HUgn7479
ECgene: WNT8B Kegg: 7479 H-InvDB: WNT8B

Other Databases showing WNT8B gene

(According to HUGE)
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Specialized Databases showing WNT8B gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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PharmGKB entry for WNT8B Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for WNT8B Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property
for WNT8B gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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