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WNT8B Gene

protein-coding   GIFtS: 61
GCID: GC10P102212

Wingless-Type MMTV Integration Site Family, Member 8B

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Wingless-Type MMTV Integration Site Family, Member 8B1 2
Protein Wnt-8b2

External Ids:    HGNC: 127891   Entrez Gene: 74792   Ensembl: ENSG000000752907   OMIM: 6013965   UniProtKB: Q930983   

Export aliases for WNT8B gene to outside databases

Previous GC identifers: GC10P101116 GC10P101456 GC10P102354 GC10P101887 GC10P095851


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WNT8B Gene:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These
proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell
fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein
which shows 95%, 86% and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins,
respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the
developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial
epilepsy. (provided by RefSeq, Jul 2008)

GeneCards Summary for WNT8B Gene:
WNT8B (wingless-type MMTV integration site family, member 8B) is a protein-coding gene. GO annotations related to this gene include frizzled binding. An important paralog of this gene is WNT10B.

UniProtKB/Swiss-Prot: WNT8B_HUMAN, Q93098
Function: Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role
in the development and differentiation of certain forebrain structures, notably the hippocampus

Gene Wiki entry for WNT8B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the WNT8B gene promoter:
         Oct-B1   POU2F2 (Oct-2.1)   oct-B3   oct-B2   GATA-3   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWNT8B promoter sequence
   Search Chromatin IP Primers for WNT8B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WNT8B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24   Ensembl cytogenetic band:  10q24.31   HGNC cytogenetic band: 10q24

WNT8B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT8B gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P102212:  view genomic region     (about GC identifiers)

Start:
102,222,798 bp from pter      End:
102,243,501 bp from pter
Size:
20,704 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: WNT8B_HUMAN, Q93098 (See protein sequence)
Recommended Name: Protein Wnt-8b precursor  
Size: 351 amino acids; 38721 Da
Secondary accessions: O00771 Q5VX55 Q8WYK9

Explore the universe of human proteins at neXtProt for WNT8B: NX_Q93098

Explore proteomics data for WNT8B at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn103, Asn259

  • See WNT8B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003384.2  
    ENSEMBL proteins: 
     ENSP00000340677  
    Reactome Protein details: Q93098

    WNT8B Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for WNT8B

     
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    antibodies-online proteins for WNT8B (3 products) 

     
    antibodies-online peptides for WNT8B

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WNT: Wingless-type MMTV integration sites

    3 InterPro protein domains:
     IPR013301 Wnt8
     IPR005817 Wnt
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry Q93098

    ProtoNet protein and cluster: Q93098

    1 Blocks protein domain: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WNT8B_HUMAN, Q93098
    Similarity: Belongs to the Wnt family


    Find genes that share domains with WNT8B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WNT8B_HUMAN, Q93098
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role
    in the development and differentiation of certain forebrain structures, notably the hippocampus

         Genatlas biochemistry entry for WNT8B:
    wingless-type MMTV integration site 8B,member of the WNT family encoding intercellular signaling
    molecules,expressed in the developing forebrain,Drosophila wingless (Wg) segment polarity gene homolog,modulating
    cell fate and cell behavior during vertebrate development

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005109frizzled binding IBA--
         
    Find genes that share ontologies with WNT8B           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Wnt8b):
     nervous system 

    Find genes that share phenotypes with WNT8B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Wnt8btm1Jmas for WNT8B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WNT8B
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    miRNA
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    miRTarBase miRNAs that target WNT8B:
    hsa-mir-7-5p (MIRT025654)

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    SwitchGear 3'UTR luciferase reporter plasmidWNT8B 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WNT8B_HUMAN, Q93098: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus3
    plasma membrane3
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IBA--

    Find genes that share ontologies with WNT8B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WNT8B About   (see all 18)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt Pathway
    Wnt Pathway0.56
    WNT ligand biogenesis and trafficking0.56
    2Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathways0.40
    3Basal cell carcinoma
    Basal cell carcinoma0.43
    Melanogenesis0.32
    Hedgehog signaling pathway0.43
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    GSK3 Signaling0.61


    Find genes that share SuperPaths with WNT8B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for WNT8B
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for WNT8B (see all 8)
        GSK3 Signaling
    Factors Promoting Cardiogenesis in Vertebrates
    Presenilin-Mediated Signaling
    Human Embryonic Stem Cell Pluripotency
    Colorectal Cancer Metastasis

    1 Tocris Bioscience Pathway for WNT8B
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT8B
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    4 Reactome Pathways for WNT8B
        disassembly of the destruction complex and recruitment of AXIN to the membrane
    WNT ligand biogenesis and trafficking
    TCF dependent signaling in response to WNT
    Class B/2 (Secretin family receptors)


    Selected Kegg Pathways  (Kegg details for WNT8B) (see all 8):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT8B: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for WNT8B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WNT8B (ENSP000003406774) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CER1ENSP000003702974STRING: ENSP00000370297
    FZD10ENSP000002290304STRING: ENSP00000229030
    FZD3ENSP000002400934STRING: ENSP00000240093
    FZD6ENSP000003516054STRING: ENSP00000351605
    FZD9ENSP000003457854STRING: ENSP00000345785
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS9536085
    GO:0007275multicellular organismal development ----
    GO:0007369gastrulation ISS7635061
    GO:0007399nervous system development TAS9536085
    GO:0010628positive regulation of gene expression IEA--

    Find genes that share ontologies with WNT8B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WNT8B



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WNT8B gene: 
    NM_003393.3  

    Unigene Cluster for WNT8B:

    Wingless-type MMTV integration site family, member 8B
    Hs.421281  [show with all ESTs]
    Unigene Representative Sequence: Y11094
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000343737(uc001krb.3)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat WNT8B
      QuantiFast Probe-based Assays in human, mouse, rat WNT8B

    Additional mRNA sequence: 

    AB073637.1 X91940.1 Y11094.1 

    1 DOTS entry:

    DT.91705411 

    7 AceView cDNA sequences:

    AB073637 X91940 BF732616 NM_003393 Y11094 BF354999 BX279669 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WNT8B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGGACTTT
    WNT8B Expression
    About this image


    WNT8B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 20 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
             Thalamus
             Olfactory Bulb   
     
     Neurons
             Dopaminergic Progenitor Cells Substantia Nigra pars Compacta
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Telencephalon
             Floor plate-like cells
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Neural Ectoderm (Nervous System)
             Neural ectoderm cells
    WNT8B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WNT8B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.421281

    UniProtKB/Swiss-Prot: WNT8B_HUMAN, Q93098
    Tissue specificity: Expression is restricted to the brain, and more specifically to the forebrain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT8B: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WNT8B gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wnt8b1 , 5 wingless related MMTV integration site 8b1, 5 89.08(n)1
    96.55(a)1
      19 (37.98 cM)5
    224231  NM_011720.31  NP_035850.21 
     444934725 
    chicken
    (Gallus gallus)
    Aves WNT8B1 wingless-type MMTV integration site family, member more 79.71(n)
    88(a)
      428953  XM_426508.3  XP_426508.3 
    lizard
    (Anolis carolinensis)
    Reptilia WNT8B6
    wingless-type MMTV integration site family, member...
    85(a)
    1 ↔ 1
    GL343388.1(202405-226057)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xwnt-8b2 Xwnt-8b protein 78.21(n)    U22173.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wnt8b2 wnt8b 82.19(n)   30144  U10870.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta wntD6
    wnt inhibitor of Dorsal
    26(a)
    many ↔ many
    3R(9117774-9118920)
    worm
    (Caenorhabditis elegans)
    Secernentea lin-446
    Protein LIN-44, isoform a (lin-44) mRNA, complete ...
    25(a)
    many ↔ many
    I(4126056-4129307) WBGene00003029


    ENSEMBL Gene Tree for WNT8B (if available)
    TreeFam Gene Tree for WNT8B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WNT8B gene
    WNT10B2  WNT8A2  WNT9B2  WNT10A2  WNT9A2  
    16 SIMAP similar genes for WNT8B using alignment to 1 protein entry:     WNT8B_HUMAN:
    WNT8A    WNT2    WNT4    WNT5B    WNT2B    WNT5A
    WNT9A    WNT7B    WNT9B    WNT1    WNT16    WNT11
    WNT7A    WNT3    WNT3A    WNT6

    Find genes that share paralogs with WNT8B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WNT8B (see all 438)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362884
    A colorectal cancer sample4--see VAR_0362882 E Q mis40--------
    rs1926215501,2
    --102220935(+) TGCCCA/GAATCT 1 -- us2k10--------
    rs1505154431,2
    --102220950(+) TACCTC/TCCAAT 1 -- us2k10--------
    rs1855746111,2
    --102220967(+) TTGCAC/TCCCTT 1 -- us2k10--------
    rs49194641,2
    C,F,A--102221195(+) CAAATA/GAAGAC 1 -- us2k111Minor allele frequency- G:0.16NA CSA WA EA 510
    rs1383096331,2
    --102221217(+) GATTCC/TATGTG 1 -- us2k10--------
    rs1904803861,2
    --102221271(+) TAAATC/TGTCTG 1 -- us2k10--------
    rs1496496591,2
    --102221375(+) TAAAAC/GAAAAG 1 -- us2k10--------
    rs1930884741,2
    --102221380(+) GAAAAG/TAACAA 1 -- us2k10--------
    rs1847204021,2
    --102221401(+) CTCAGA/GGAGAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for WNT8B (102222798 - 102243501 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for WNT8B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv819434CNV Loss19587683
    nsv831963CNV Loss17160897
    dgv811n71CNV Loss21882294
    nsv895957CNV Gain21882294
    nsv818783CNV Gain17921354
    esv34217CNV Gain17911159
    nsv831962CNV Gain17160897
    nsv8723CNV Gain18304495
    essv24916CNV CNV17122850
    dgv318e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601396    OMIM disorders: --


    Find genes that share disorders with WNT8B           About GenesLikeMe

    Genetic Association Database (GAD): WNT8B
    Human Genome Epidemiology (HuGE) Navigator: WNT8B (3 documents)

    Export disorders for WNT8B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WNT8B gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with WNT8B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of WNT8B, a novel human Wnt gene that maps to 10q24. (PubMed id 8661156)1, 2, 3, 9 Lako M.... Lindsay S. (Genomics 1996)
    2. Up-regulation of WNT8B mRNA in human gastric cancer. (PubMed id 11788899)1, 2, 9 Saitoh T.... Katoh M. (Int. J. Oncol. 2002)
    3. A novel mammalian Wnt gene, WNT8B, shows brain-restricted expression in early development, with sharply delimited expression boundaries in the developing forebrain. (PubMed id 9536085)1, 2, 9 Lako M.... Strachan T. (Hum. Mol. Genet. 1998)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    5. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    6. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PubMed id 23362303)1 Wu J.H....Mozaffarian D. (Circ Cardiovasc Genet 2013)
    7. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    8. [Mutation and expression of WNT8b gene and SHH gene in Hirschsprung disease]. (PubMed id 20972907)1 Gao H....Wang W.L. (Zhonghua Wei Chang Wai Ke Za Zhi 2010)
    9. Conserved POU/OCT- and GATA-binding sites in 5'-flanking promoter region of mammalian WNT8B orthologs. (PubMed id 17390031)1 Katoh M. and Katoh M. (Int. J. Oncol. 2007)
    10. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7479 HGNC: 12789 AceView: WNT8B Ensembl:ENSG00000075290 euGenes: HUgn7479
    ECgene: WNT8B Kegg: 7479 H-InvDB: WNT8B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WNT8B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT8B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WNT8B gene:
    Search GeneIP for patents involving WNT8B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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