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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

WNT8A Gene

protein-coding GIFtS: 59
GCID: GC05P137447

wingless-type MMTV integration site family, member 8A

Explore 9 diseases affiliated with
WNT8A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Wingless-Type MMTV Integration Site Family, Member 8A¹ ²
WNT8D¹ ² ³
Protein Wnt-8d² ³
WNT8d²
Protein Wnt-8a²

External Ids:	HGNC: 12788¹	Entrez Gene: 7478²	Ensembl: ENSG00000061492⁷	OMIM: 606360⁵	UniProtKB: Q9H1J5³

Export aliases for WNT8A gene to outside databases

Previous GC identifers: GC05P137294 GC05P138095 GC05P137450 GC05P137495 GC05P132610

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WNT8A:

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins

have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and

patterning during embryogenesis. This gene is a member of the WNT gene family, and may be implicated in development of

early embryos as well as germ cell tumors. It encodes a protein which shows 81% amino acid identity to the mouse Wnt8A

protein. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: WNT8A_HUMAN, Q9H1J5

Function: Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the

development and differentiation of certain forebrain structures, notably the hippocampus

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_034772.6

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the WNT8A gene promoter:
SRF p53 AML1a SRF (504 AA) Lmo2 Pax-2a HNF-4alpha2 HNF-4alpha1 AREB6 Egr-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WNT8A promoter sequence

Search SABiosciences Chromatin IP Primers for WNT8A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WNT8A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31 Ensembl cytogenetic band: 5q31.2 HGNC cytogenetic band: 5q31

WNT8A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT8A gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P137447: view genomic region (about GC identifiers)

Start:	137,419,581 bp from pter	End:	137,428,054 bp from pter
Size:	8,474 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: WNT8A_HUMAN, Q9H1J5 (See protein sequence)

Recommended Name: Protein Wnt-8a precursor

Size: 351 amino acids; 38849 Da

Subcellular location: Secreted, extracellular space, extracellular matrix

Secondary accessions: Q96S51

Alternative splicing: 2 isoforms: Q9H1J5-1 Q9H1J5-2 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for WNT8A: NX_Q9H1J5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9H1J5

WNT8A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_490645.1

ENSEMBL proteins:

ENSP00000426653 ENSP00000354726 ENSP00000424809 ENSP00000381739

Reactome Protein details: Q9H1J5
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: WNT8A OriGene Protein Over-expression Lysate: WNT8A OriGene Custom Protein Services for WNT8A
	GenScript Custom Purified and Recombinant Proteins Services for WNT8A
	Novus Biologicals WNT8A Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for WNT8A

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005578	proteinaceous extracellular matrix	ISS	--
GO:0005615	colocalizes with extracellular space	ISS	--
GO:0005886	plasma membrane	IBA	--

WNT8A for ontologies About GeneDecksing

WNT8A Antibody Products:

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	GenScript Custom Superior Antibodies Services for WNT8A
	Novus Biologicals WNT8A Antibodies
	Search for Antibodies for WNT8A at Abcam
	Uscn Antibodies for WNT8A
	Search ThermoFisher Antibodies for WNT8A

Assay Products for WNT8A:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for WNT8A
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for WNT8A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

WNT8A for domains About GeneDecksing

3 InterPro domains/families:

IPR013301 Wnt8

IPR005817 Wnt

IPR018161 Wnt_CS

Graphical View of Domain Structure for InterPro Entry Q9H1J5

ProtoNet protein and cluster: Q9H1J5

1 Blocks protein family: IPB005816 Secreted growth factor Wnt protein

UniProtKB/Swiss-Prot: WNT8A_HUMAN, Q9H1J5

Similarity: Belongs to the Wnt family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: WNT8A_HUMAN, Q9H1J5

Function: Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the

development and differentiation of certain forebrain structures, notably the hippocampus

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WNT8A
		1 QIAGEN miScript miRNA Assays for microRNA that regulate WNT8A:
		hsa-miR-147
		SwitchGear 3'UTR luciferase reporter plasmid: WNT8A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WNT8A (see all 7) OriGene shRNA RFP: WNT8A OriGene siRNA: WNT8A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WNT8A

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for WNT8A

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WNT8A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WNT8A (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: WNT8A (NM_058244)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for WNT8A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT8A

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for WNT8A
		Search LifeMap BioReagents cell lines for WNT8A

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT8A

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001664	G-protein coupled receptor binding	IBA	--
GO:0005102	receptor binding	--	--
GO:0005109	frizzled binding	NAS	11408932
GO:0005515	protein binding	--	--
GO:0048018	receptor agonist activity	NAS	11408932

WNT8A for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for WNT8A:

Cell cycle / mitosis defect

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Basal cell carcinoma

	Basal cell carcinoma	1.00			Wnt Pathway	0.37
	Hedgehog signaling pathway	0.41			Melanogenesis	0.32

Translation_Non-genomic (rapid) action of Androgen Receptor

Translation_Non-genomic (rapid) action of Androgen Receptor

1.00

Translation Non-genomic (rapid) action of Androgen Receptor

0.99

Transcription_Androgen Receptor nuclear signaling

Transcription_Androgen Receptor nuclear signaling

1.00

Transcription Androgen Receptor nuclear signaling

0.99

Nanog in Mammalian ESC Pluripotency

Nanog in Mammalian ESC Pluripotency

1.00

GSK3 Signaling

0.61

Human Embryonic Stem Cell Pluripotency

Human Embryonic Stem Cell Pluripotency

1.00

Factors Promoting Cardiogenesis in Vertebrates

0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for WNT8A

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

1 R&D Systems Pathway for WNT8A

Wnt Signaling Pathway

5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for WNT8A (see all 8)

	GSK3 Signaling
	Factors Promoting Cardiogenesis in Vertebrates
	Presenilin-Mediated Signaling
	Human Embryonic Stem Cell Pluripotency
	Colorectal Cancer Metastasis

1 Tocris Bioscience Pathway for WNT8A

Wnt Pathway

2 GeneGo (Thomson Reuters) Pathways for WNT8A

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

1 BioSystems Pathway for WNT8A

Neural Crest Differentiation

4 Reactome Pathways for WNT8A

	Signal Transduction
	Signaling by GPCR
	GPCR ligand binding
	Class B/2 (Secretin family receptors)

5 Kegg Pathways (Kegg details for WNT8A):

	Wnt signaling pathway
	Hedgehog signaling pathway
	Melanogenesis
	Pathways in cancer
	Basal cell carcinoma

WNT8A for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for WNT8A

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

5/17 Interacting proteins for WNT8A (Q9H1J5³ ENSP00000381739⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SFRP1	Q8N474³, ENSP00000220772⁴	I2D: score=1 STRING: ENSP00000220772
CER1	ENSP00000370297⁴	STRING: ENSP00000370297
FZD1	ENSP00000287934⁴	STRING: ENSP00000287934
FZD10	ENSP00000229030⁴	STRING: ENSP00000229030
FZD2	ENSP00000323901⁴	STRING: ENSP00000323901

About this table

Gene Ontology (GO): 5/30 biological process terms (GO ID links to tree view) (see all 30): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000902	cell morphogenesis	--	--
GO:0001654	eye development	IBA	--
GO:0001710	mesodermal cell fate commitment	IBA	--
GO:0001756	somitogenesis	IBA	--
GO:0003002	regionalization	--	--

WNT8A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EMD Millipore small molecules for WNT8A:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for WNT8A
Search CenterWatch for drugs/clinical trials and news about WNT8A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for WNT8A gene (2 alternative transcripts):

NM_058244.2 NM_031933.1

Unigene Cluster for WNT8A:

Wingless-type MMTV integration site family, member 8A

Hs.591274

Unigene Representative Sequence: BC144497

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000506684(uc011cyj.1 uc011cyk.1) ENST00000361560 ENST00000504809

ENST00000398754(uc003lcd.1)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WNT8A
		1 QIAGEN miScript miRNA Assays for microRNA that regulate WNT8A:
		hsa-miR-147
		SwitchGear 3'UTR luciferase reporter plasmid: WNT8A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WNT8A (see all 7) OriGene shRNA RFP: WNT8A OriGene siRNA: WNT8A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WNT8A

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WNT8A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WNT8A (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: WNT8A (NM_058244)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for WNT8A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT8A

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WNT8A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat WNT8A
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WNT8A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WNT8A

Additional cDNA sequence:

AB057725.1 BC144001.1 BC144497.1

1 DOTS entry:

DT.95148953

6 AceView cDNA sequences:

AY009402 AB057725 NM_031933 NM_058244 AW663893 BQ428931

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for WNT8A About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7
SP1:
SP2:

ECgene alternative splicing isoforms for WNT8A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

WNT8A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCAACCCAG

About this image

WNT8A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Primitive Streak

Primitive Streak Cells

Early Embryo

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See WNT8A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WNT8A

SOURCE GeneReport for Unigene cluster: Hs.591274

SABiosciences Expression via Pathway-Focused PCR Arrays including WNT8A:

Hedgehog Signaling Pathway in human mouse rat

WNT Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WNT8A Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WNT8A

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT8A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for WNT8A gene from 7/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Wnt8a^{1 , 5}	wingless-related MMTV integration site 8A^{1, 5}	83.86(n)¹ 81.09(a)¹		18 (18.69 cM)⁵ 20890¹ NM_009290.2¹ NP_033316.1¹ 34542328⁵
chicken (Gallus gallus)	Aves	WNT8A¹	wingless-type MMTV integration site family, member more	73.79(n) 74.18(a)		396543 NM_205531.1 NP_990862.1
lizard (Anolis carolinensis)	Reptilia	WNT8A⁶	--	68(a)	1 ↔ 1	2(142098490-142104836)
African clawed frog (Xenopus laevis)	Amphibia	Xwnt-8²	X.laevis Xwnt-8 mRNA	73.83(n)		X57234.1
zebrafish (Danio rerio)	Actinopterygii	NM_130946.1²	--	74.32(n)		30122 NM_130946.1
fruit fly (Drosophila melanogaster)	Insecta	wntD⁶	wnt inhibitor of Dorsal	22(a)	possible ortholog	3R(9117774-9118920)
worm (Caenorhabditis elegans)	Secernentea	lin-44⁶	Abnormal cell lineage protein 44	25(a)	possible ortholog	I(4126058-4129309)

ENSEMBL Gene Tree for WNT8A (if available)
TreeFam Gene Tree for WNT8A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for WNT8A gene

WNT8B² WNT9B² WNT9A²

17 SIMAP similar genes for WNT8A using alignment to 3 protein entries: WNT8A_HUMAN (see all proteins):

WNT8B WNT2B WNT5B WNT7B WNT2 WNT5A

WNT16 WNT7A WNT4 WNT1 WNT3 WNT3A

WNT9B WNT11 WNT6 WNT9A WNT10B

WNT8A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs4835761^1,2	C,F,A,H,	--	137417869(+)	`CTTTTG/ATTCTA`	1	--	us2k¹		24		NS EA NA WA CSA	2532
rs142627539^1,2		--	137417935(+)	`CATCCA/GGGTGC`	1	--	us2k¹		0	--	--	--	--
rs183538890^1,2		--	137418065(+)	`GGAGTC/TTGAGA`	1	--	us2k¹		0	--	--	--	--
rs11242416^1,2	C,F,A,	--	137418317(+)	`TAATCG/CCAGCA`	1	--	us2k¹		5		NA CSA	10
rs112183305^1,2	C,	--	137418411(+)	`AAATAC/TAAAAA`	1	--	us2k¹		0	--	--	--	--
rs186078167^1,2		--	137418543(+)	`CCTGGC/TGACAG`	1	--	us2k¹		0	--	--	--	--
rs141249412^1,2		--	137418959(+)	`AGCGAA/GAGACT`	1	--	us2k¹		0	--	--	--	--
rs5871664^1,2	C	--	137418972(+)	`GTCTC-/AAAAAA`	1	--	us2k¹ trp³		0	--	--	--	--
rs190741132^1,2		--	137419003(+)	`TCAGTC/TTTCCC`	1	--	us2k¹		0	--	--	--	--
rs150861757^1,2		--	137419048(+)	`CAGATA/GTATAA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for WNT8A (137419581 - 137428054 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for WNT8A: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WNT8A

DNA2.0 Custom Variant and Variant Library Synthesis for WNT8A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

WNT8A for disorders           About GeneDecksing

OMIM gene information: 606360    OMIM disorders: --

9 diseases for WNT8A:    About MalaCards

cleft lip/palate cleft lip tooth agenesis germ cell tumor

cleft palate basal cell carcinoma hermaphroditism carcinoma

colorectal cancer

1 disease from the University of Copenhagen DISEASES database for WNT8A:

Cleft lip

Human Genome Epidemiology (HuGE) Navigator: WNT8A (3 documents)

Export disorders for WNT8A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for WNT8A gene integrated from 9 sources:
(articles sorted by number of sources associating them with WNT8A)

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Molecular cloning and characterization of human WNT8A. (PubMed id 11408932)^{1, 2, 3} Saitoh T. and Katoh M. (2001)
Meta-analysis identifies six new susceptibility loci f or atrial fibrillation. (PubMed id 22544366)¹ Ellinor P.T....Kaab S. (2012)
Proteomics strategy to identify substrates of LNX, a P DZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)¹ Guo Z....Gao Y. (2012)
Studies with Wnt genes and nonsyndromic cleft lip and palate. (PubMed id 20890934)¹ Menezes R....Vieira A.R. (2010)
Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate. (PubMed id 18413325)¹ Chiquet B.T....Hecht J.T. (2008)
Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines: up-regulation of WNT8B mRNA by beta-estradiol in MCF-7 cells, and down-regulation of WNT8A and WNT8B mRNAs by retinoic acid in NT2 cells. (PubMed id 11956596)¹ Saitoh T....Katoh M. (2002)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Wnt family proteins are secreted and associated with the cell surface. (PubMed id 8167409)¹ Smolich B.D....Papkoff J. (1993)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7478	HGNC: 12788	AceView: WNT8A	Ensembl:ENSG00000061492	euGenes: HUgn7478
ECgene: WNT8A	Kegg: 7478	H-InvDB: WNT8A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for WNT8A	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for WNT8A	Genetics and Cytogenetics in Oncology and Haematology

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wingless-type MMTV integration site family, member 8A

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WNT8A Gene

wingless-type MMTV integration site family, member 8A

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