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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WNT8A Gene

protein-coding   GIFtS: 62
GCID: GC05P137447

Wingless-Type MMTV Integration Site Family, Member 8A

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Wingless-Type MMTV Integration Site Family, Member 8A1 2
Protein Wnt-8d2 3
WNT8D2 3
WNT8d2
Protein Wnt-8a2

External Ids:    HGNC: 127881   Entrez Gene: 74782   Ensembl: ENSG000000614927   OMIM: 6063605   UniProtKB: Q9H1J53   

Export aliases for WNT8A gene to outside databases

Previous GC identifers: GC05P137294 GC05P138095 GC05P137450 GC05P137495 GC05P132610


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WNT8A Gene:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These
proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell
fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and may be implicated in
development of early embryos as well as germ cell tumors. It encodes a protein which shows 81% amino acid
identity to the mouse Wnt8A protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for WNT8A Gene: 
WNT8A (wingless-type MMTV integration site family, member 8A) is a protein-coding gene. Diseases associated with WNT8A include germ cell tumors, and tooth agenesis, and among its related super-pathways are Basal cell carcinoma and Wnt signaling pathway. GO annotations related to this gene include receptor agonist activity and G-protein coupled receptor binding. An important paralog of this gene is WNT8B.

UniProtKB/Swiss-Prot: WNT8A_HUMAN, Q9H1J5
Function: Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role
in the development and differentiation of certain forebrain structures, notably the hippocampus




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_034772.6  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WNT8A gene promoter:
         SRF   p53   AML1a   SRF (504 AA)   Lmo2   Pax-2a   HNF-4alpha2   HNF-4alpha1   AREB6   Egr-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWNT8A promoter sequence
   Search SABiosciences Chromatin IP Primers for WNT8A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WNT8A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q31.2   HGNC cytogenetic band: 5q31

WNT8A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT8A gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P137447:  view genomic region     (about GC identifiers)

Start:
137,419,581 bp from pter      End:
137,428,054 bp from pter
Size:
8,474 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WNT8A_HUMAN, Q9H1J5 (See protein sequence)
Recommended Name: Protein Wnt-8a precursor  
Size: 351 amino acids; 38849 Da
Subcellular location: Secreted, extracellular space, extracellular matrix
Secondary accessions: Q96S51
Alternative splicing: 2 isoforms:  Q9H1J5-1   Q9H1J5-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for WNT8A: NX_Q9H1J5

Explore proteomics data for WNT8A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H1J5

  • WNT8A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WNT8A Protein Expression
    REFSEQ proteins: NP_490645.1  
    ENSEMBL proteins: 
     ENSP00000426653   ENSP00000354726   ENSP00000424809   ENSP00000381739  
    Reactome Protein details: Q9H1J5
    Human Recombinant Protein Products for WNT8A: 
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    Novus Biologicals WNT8A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WNT8A 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix ISS--
    GO:0005615colocalizes with extracellular space ISS--

    WNT8A for ontologies           About GeneDecksing



    WNT8A Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WNT: Wingless-type MMTV integration sites

    3 InterPro protein domains:
     IPR013301 Wnt8
     IPR005817 Wnt
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry Q9H1J5

    ProtoNet protein and cluster: Q9H1J5

    1 Blocks protein domain: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WNT8A_HUMAN, Q9H1J5
    Similarity: Belongs to the Wnt family


    WNT8A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WNT8A_HUMAN, Q9H1J5
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role
    in the development and differentiation of certain forebrain structures, notably the hippocampus

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005109frizzled binding NAS11408932
    GO:0005515protein binding ----
    GO:0048018receptor agonist activity NAS11408932
         
    WNT8A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for WNT8A:
     Cell cycle / mitosis defect 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Wnt8a):
     hearing/vestibular/ear  normal 

    WNT8A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Wnt8atm1(KOMP)Vlcg for WNT8A

       inGenious Targeting Laboratory - Custom generated mouse model solutions for WNT8A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for WNT8A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WNT8A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WNT8A 

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate WNT8A:
    hsa-miR-147
    SwitchGear 3'UTR luciferase reporter plasmidWNT8A 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT8A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for WNT8A About   (see all 18)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Basal cell carcinoma
    Hedgehog signaling pathway0.43
    Wnt Pathway0.39
    Basal cell carcinoma0.43
    Melanogenesis0.32
    2Wnt signaling pathway
    Wnt signaling pathway0.40
    Wnt Signaling Pathway0.40
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    4Asparagine N-linked glycosylation
    WNT ligand biogenesis and trafficking0.77
    Signaling by Wnt0.62
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    GSK3 Signaling0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for WNT8A
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    1 R&D Systems Pathway for WNT8A
        Wnt Signaling Pathway

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for WNT8A (see all 8)
        GSK3 Signaling
    Factors Promoting Cardiogenesis in Vertebrates
    Presenilin-Mediated Signaling
    Human Embryonic Stem Cell Pluripotency
    Colorectal Cancer Metastasis

    1 Tocris Bioscience Pathway for WNT8A
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT8A
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    1 BioSystems Pathway for WNT8A
        Neural Crest Differentiation

    5/6        Reactome Pathways for WNT8A (see all 6)
        Signaling by Wnt
    Signal Transduction
    Signaling by GPCR
    WNT ligand biogenesis and trafficking
    GPCR ligand binding


    5/8         Kegg Pathways  (Kegg details for WNT8A) (see all 8):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection


    WNT8A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WNT8A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/17 Interacting proteins for WNT8A (Q9H1J53 ENSP000003817394) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFRP1Q8N4743, ENSP000002207724I2D: score=1 STRING: ENSP00000220772
    CER1ENSP000003702974STRING: ENSP00000370297
    FZD1ENSP000002879344STRING: ENSP00000287934
    FZD10ENSP000002290304STRING: ENSP00000229030
    FZD2ENSP000003239014STRING: ENSP00000323901
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ----
    GO:0003002regionalization ----
    GO:0007275multicellular organismal development ----
    GO:0007492endoderm development IEA--
    GO:0009949polarity specification of anterior/posterior axis IEA--

    WNT8A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for WNT8A:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WNT8A

    Search CenterWatch for drugs/clinical trials and news about WNT8A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WNT8A gene (2 alternative transcripts): 
    NM_058244.2  NM_031933.1  

    Unigene Cluster for WNT8A:

    Wingless-type MMTV integration site family, member 8A
    Hs.591274
    Unigene Representative Sequence: BC144497
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506684(uc011cyj.1 uc011cyk.1) ENST00000361560 ENST00000504809
    ENST00000398754(uc003lcd.1)
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate WNT8A:
    hsa-miR-147
    SwitchGear 3'UTR luciferase reporter plasmidWNT8A 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT8A
    Sirion Biotech Customized lentivirus for stable overexpression of WNT8A 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WNT8A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WNT8A

    Additional mRNA sequence: 

    AB057725.1 BC144001.1 BC144497.1 

    1 DOTS entry:

    DT.95148953 

    6 AceView cDNA sequences:

    AW663893 AB057725 NM_031933 AY009402 NM_058244 BQ428931 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for WNT8A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
    SP1:                                                
    SP2:                                                


    ECgene alternative splicing isoforms for WNT8A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WNT8A expression in normal human tissues (normalized intensities)      WNT8A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCAACCCAG
    WNT8A Expression
    About this image


    WNT8A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
             brain/forebrain/telencephalon   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Membranous Facial Bones
             skeleton/cranium   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
             Epiblast Stem Cell line 5
     
     Gut Tube (Gastrointestinal Tract)
             Foregut

    See WNT8A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WNT8A

    SOURCE GeneReport for Unigene cluster: Hs.591274
        SABiosciences Expression via Pathway-Focused PCR Arrays including WNT8A: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WNT8A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT8A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for WNT8A gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wnt8a1 , 5 wingless-related MMTV integration site 8A1, 5 83.86(n)1
    81.09(a)1
      18 (18.69 cM)5
    208901  NM_009290.21  NP_033316.11 
     345423285 
    chicken
    (Gallus gallus)
    Aves WNT8A1 wingless-type MMTV integration site family, member more 73.79(n)
    74.18(a)
      396543  NM_205531.1  NP_990862.1 
    lizard
    (Anolis carolinensis)
    Reptilia WNT8A6
    Protein Wnt
    68(a)
    1 ↔ 1
    2(142098490-142104836)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xwnt-82 X.laevis Xwnt-8 mRNA 73.83(n)    X57234.1 
    zebrafish
    (Danio rerio)
    Actinopterygii NM_130946.12   -- 74.32(n)   30122  NM_130946.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta wntD6
    wnt inhibitor of Dorsal
    22(a)
    1 → many
    3R(9117774-9118920)
    worm
    (Caenorhabditis elegans)
    Secernentea lin-446
    Abnormal cell lineage protein 44
    24(a)
    1 → many
    I(4126056-4129307)


    ENSEMBL Gene Tree for WNT8A (if available)
    TreeFam Gene Tree for WNT8A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WNT8A gene
    WNT8B2  WNT9B2  WNT9A2  
    16 SIMAP similar genes for WNT8A using alignment to 3 protein entries:     WNT8A_HUMAN (see all proteins):
    WNT8B    WNT2B    WNT5B    WNT7B    WNT2    WNT5A
    WNT16    WNT7A    WNT4    WNT1    WNT3    WNT3A
    WNT9B    WNT11    WNT6    WNT9A

    WNT8A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/243 SNPs in WNT8A are shown (see all 243)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs48357611,2
    C,F,A,H--137417869(+) CTTTTG/ATTCTA 1 -- us2k124Minor allele frequency- A:0.46NS EA NA WA CSA 2532
    rs1426275391,2
    --137417935(+) CATCCA/GGGTGC 1 -- us2k10--------
    rs1835388901,2
    C--137418065(+) GGAGTC/TTGAGA 1 -- us2k10--------
    rs112424161,2
    C,F,A--137418317(+) TAATCG/CCAGCA 1 -- us2k15Minor allele frequency- C:0.30NA CSA 10
    rs1121833051,2
    C--137418411(+) AAATAC/TAAAAA 1 -- us2k10--------
    rs1860781671,2
    C--137418543(+) CCTGGC/TGACAG 1 -- us2k10--------
    rs106900191,2
    C--137418601(+) taaat-/AAATA/
    AAATAAAT
    aaata
    1 -- us2k1 tfbs30--------
    rs666480311,2
    C--137418605(+) ATAAA-/A/TA  
      AATAAA
    TAAAA
    1 -- us2k10--------
    rs1412494121,2
    C--137418959(+) AGCGAA/GAGACT 1 -- us2k10--------
    rs58716641,2
    C--137418972(+) GTCTC-/AAAAAA 1 -- us2k1 trp30--------

    HapMap Linkage Disequilibrium report for WNT8A (137419581 - 137428054 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for WNT8A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830502CNV Gain17160897


    Human Gene Mutation Database (HGMD): WNT8A
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing WNT8A
    DNA2.0 Custom Variant and Variant Library Synthesis for WNT8A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606360    OMIM disorders: --

    6 diseases for WNT8A:    About MalaCards
    germ cell tumors    tooth agenesis    cleft lip    cleft palate
    basal cell carcinoma    colorectal cancer

    1 disease from the University of Copenhagen DISEASES database for WNT8A:
    Cleft lip

    WNT8A for disorders           About GeneDecksing

    Genetic Association Database (GAD): WNT8A
    Human Genome Epidemiology (HuGE) Navigator: WNT8A (3 documents)

    Export disorders for WNT8A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WNT8A gene integrated from 9 sources:
    (articles sorted by number of sources associating them with WNT8A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of human WNT8A. (PubMed id 11408932)1, 2, 3 Saitoh T. and Katoh M. (2001)
    2. Studies with Wnt genes and nonsyndromic cleft lip and palate. (PubMed id 20890934)1, 4 Menezes R....Vieira A.R. (2010)
    3. Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate. (PubMed id 18413325)1, 4 Chiquet B.T....Hecht J.T. (2008)
    4. Meta-analysis identifies six new susceptibility loci f or atrial fibrillation. (PubMed id 22544366)1 Ellinor P.T....Kaab S. (2012)
    5. Proteomics strategy to identify substrates of LNX, a P DZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)1 Guo Z....Gao Y. (2012)
    6. Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines: up-regulation of WNT8B mRNA by beta-estradiol in MCF-7 cells, and down-regulation of WNT8A and WNT8B mRNAs by retinoic acid in NT2 cells. (PubMed id 11956596)1 Saitoh T....Katoh M. (2002)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Wnt family proteins are secreted and associated with the cell surface. (PubMed id 8167409)1 Smolich B.D....Papkoff J. (1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7478 HGNC: 12788 AceView: WNT8A Ensembl:ENSG00000061492 euGenes: HUgn7478
    ECgene: WNT8A Kegg: 7478 H-InvDB: WNT8A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WNT8A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT8A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WNT8A gene:
    Search GeneIP for patents involving WNT8A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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