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Aliases for WNT8A Gene

Aliases for WNT8A Gene

  • Wingless-Type MMTV Integration Site Family, Member 8A 2 3
  • Protein Wnt-8d 3 4
  • WNT8d 3 4
  • Protein Wnt-8a 3

External Ids for WNT8A Gene

Previous GeneCards Identifiers for WNT8A Gene

  • GC05P137294
  • GC05P137450
  • GC05P137495
  • GC05P137447
  • GC05P132610

Summaries for WNT8A Gene

Entrez Gene Summary for WNT8A Gene

  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and may be implicated in development of early embryos as well as germ cell tumors. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for WNT8A Gene

WNT8A (Wingless-Type MMTV Integration Site Family, Member 8A) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include frizzled binding and receptor agonist activity. An important paralog of this gene is WNT10B.

UniProtKB/Swiss-Prot for WNT8A Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT8A Gene

Genomics for WNT8A Gene

Regulatory Elements for WNT8A Gene

Genomic Location for WNT8A Gene

Start:
138,083,892 bp from pter
End:
138,092,648 bp from pter
Size:
8,757 bases
Orientation:
Plus strand

Genomic View for WNT8A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WNT8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT8A Gene

Proteins for WNT8A Gene

  • Protein details for WNT8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1J5-WNT8A_HUMAN
    Recommended name:
    Protein Wnt-8a
    Protein Accession:
    Q9H1J5
    Secondary Accessions:
    • Q96S51

    Protein attributes for WNT8A Gene

    Size:
    351 amino acids
    Molecular mass:
    38849 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WNT8A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WNT8A Gene

Proteomics data for WNT8A Gene at MOPED

Post-translational modifications for WNT8A Gene

  • Palmitoleylation is required for efficient binding to frizzled receptors (By similarity). Depalmitoleylation leads to Wnt signaling pathway inhibition (By similarity).
  • Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT8A.
  • Glycosylation at Asn103, Asn262, and Asn281
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT8A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for WNT8A Gene

Domains for WNT8A Gene

Gene Families for WNT8A Gene

HGNC:
  • WNT :Wingless-type MMTV integration sites

Protein Domains for WNT8A Gene

Suggested Antigen Peptide Sequences for WNT8A Gene

Graphical View of Domain Structure for InterPro Entry

Q9H1J5

UniProtKB/Swiss-Prot:

WNT8A_HUMAN :
  • Q9H1J5
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT8A: view

Function for WNT8A Gene

Molecular function for WNT8A Gene

UniProtKB/Swiss-Prot Function: Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus

Gene Ontology (GO) - Molecular Function for WNT8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding --
GO:0005109 frizzled binding NAS 11408932
GO:0005515 protein binding --
GO:0048018 receptor agonist activity NAS 11408932
genes like me logo Genes that share ontologies with WNT8A: view

Phenotypes for WNT8A Gene

MGI mutant phenotypes for WNT8A:
inferred from 1 alleles
GenomeRNAi human phenotypes for WNT8A:
genes like me logo Genes that share phenotypes with WNT8A: view

Animal Models for WNT8A Gene

MGI Knock Outs for WNT8A:

Animal Model Products

CRISPR Products

miRNA for WNT8A Gene

miRTarBase miRNAs that target WNT8A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WNT8A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for WNT8A Gene

Localization for WNT8A Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT8A Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WNT8A Gene COMPARTMENTS Subcellular localization image for WNT8A gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 1
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for WNT8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix ISS --
GO:0005615 colocalizes_with extracellular space ISS --
genes like me logo Genes that share ontologies with WNT8A: view

Pathways for WNT8A Gene

genes like me logo Genes that share pathways with WNT8A: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for WNT8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis --
GO:0003002 regionalization --
GO:0007275 multicellular organismal development --
GO:0007492 endoderm development --
GO:0009949 polarity specification of anterior/posterior axis --
genes like me logo Genes that share ontologies with WNT8A: view

Transcripts for WNT8A Gene

mRNA/cDNA for WNT8A Gene

(6) Selected AceView cDNA sequences:
(5) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WNT8A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WNT8A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1:
SP2:

Relevant External Links for WNT8A Gene

GeneLoc Exon Structure for
WNT8A
ECgene alternative splicing isoforms for
WNT8A

Expression for WNT8A Gene

mRNA expression in normal human tissues for WNT8A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT8A Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (8.5), Brain - Nucleus accumbens (basal ganglia) (7.8), Brain - Caudate (basal ganglia) (6.6), and Testis (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for WNT8A Gene

SOURCE GeneReport for Unigene cluster for WNT8A Gene Hs.591274

genes like me logo Genes that share expressions with WNT8A: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for WNT8A Gene

Orthologs for WNT8A Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT8A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WNT8A 35
  • 99.43 (n)
  • 99.43 (a)
WNT8A 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WNT8A 35
  • 88.79 (n)
  • 91.17 (a)
WNT8A 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WNT8A 35
  • 89.74 (n)
  • 91.74 (a)
WNT8A 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wnt8a 35
  • 83.86 (n)
  • 81.09 (a)
Wnt8a 16
Wnt8a 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 20 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Wnt8a 35
  • 84.53 (n)
  • 82.13 (a)
chicken
(Gallus gallus)
Aves WNT8A 35
  • 72.53 (n)
  • 72.33 (a)
WNT8C 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WNT8A 36
  • 68 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xwnt-8 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15027 35
wnt8a 35
  • 71.35 (n)
  • 74.27 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
wnt8a 35
  • 68.09 (n)
  • 70.52 (a)
wnt8a 36
  • 60 (a)
OneToMany
wnt8a 36
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Wnt4 36
  • 17 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea egl-20 36
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
ManyToMany
Species with no ortholog for WNT8A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT8A Gene

ENSEMBL:
Gene Tree for WNT8A (if available)
TreeFam:
Gene Tree for WNT8A (if available)

Paralogs for WNT8A Gene

Paralogs for WNT8A Gene

Selected SIMAP similar genes for WNT8A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with WNT8A: view

Variants for WNT8A Gene

Sequence variations from dbSNP and Humsavar for WNT8A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs172607 -- 138,086,398(+) ttttt(A/T)gtaga intron-variant
rs217254 -- 138,091,875(+) AATAA(A/C)TAATA downstream-variant-500B, intron-variant
rs217255 -- 138,091,988(+) AAAGG(C/G)AATCA downstream-variant-500B, intron-variant
rs217267 -- 138,085,585(+) GAACC(A/G)TGCCT intron-variant
rs217268 -- 138,086,640(+) gctca(A/C)acctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WNT8A Gene

Variant ID Type Subtype PubMed ID
nsv830502 CNV Gain 17160897

Relevant External Links for WNT8A Gene

HapMap Linkage Disequilibrium report
WNT8A
Human Gene Mutation Database (HGMD)
WNT8A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT8A Gene

Disorders for WNT8A Gene

(1) University of Copenhagen DISEASES for WNT8A Gene

Relevant External Links for WNT8A

Genetic Association Database (GAD)
WNT8A
Human Genome Epidemiology (HuGE) Navigator
WNT8A
genes like me logo Genes that share disorders with WNT8A: view

No data available for UniProtKB/Swiss-Prot for WNT8A Gene

Publications for WNT8A Gene

  1. Molecular cloning and characterization of human WNT8A. (PMID: 11408932) Saitoh T. … Katoh M. (Int. J. Oncol. 2001) 2 3 4
  2. Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate. (PMID: 18413325) Chiquet B.T. … Hecht J.T. (Hum. Mol. Genet. 2008) 3 48
  3. Studies with Wnt genes and nonsyndromic cleft lip and palate. (PMID: 20890934) Menezes R. … Vieira A.R. (Birth Defects Res. Part A Clin. Mol. Teratol. 2010) 3 48
  4. Meta-analysis identifies six new susceptibility loci for atrial fibrillation. (PMID: 22544366) Ellinor P.T. … KAoAob S. (Nat. Genet. 2012) 3
  5. Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. (PMID: 22889411) Guo Z. … Gao Y. (J. Proteome Res. 2012) 3

Products for WNT8A Gene

  • Addgene plasmids for WNT8A

Sources for WNT8A Gene

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