Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



WNT8A Gene

protein-coding   GIFtS: 61
GCID: GC05P137447

Wingless-Type MMTV Integration Site Family, Member 8A

  See WNT8A-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Wingless-Type MMTV Integration Site Family, Member 8A1 2
Protein Wnt-8d2 3
WNT8D2 3
WNT8d2
Protein Wnt-8a2

External Ids:    HGNC: 127881   Entrez Gene: 74782   Ensembl: ENSG000000614927   OMIM: 6063605   UniProtKB: Q9H1J53   

Export aliases for WNT8A gene to outside databases

Previous GC identifers: GC05P137294 GC05P138095 GC05P137450 GC05P137495 GC05P132610


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for WNT8A Gene:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These
proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell
fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and may be implicated in
development of early embryos as well as germ cell tumors. It encodes a protein which shows 81% amino acid
identity to the mouse Wnt8A protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for WNT8A Gene:
WNT8A (wingless-type MMTV integration site family, member 8A) is a protein-coding gene. Diseases associated with WNT8A include germ cell tumors. GO annotations related to this gene include receptor agonist activity and frizzled binding. An important paralog of this gene is WNT8B.

UniProtKB/Swiss-Prot: WNT8A_HUMAN, Q9H1J5
Function: Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role
in the development and differentiation of certain forebrain structures, notably the hippocampus




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WNT8A gene promoter:
         SRF   p53   AML1a   SRF (504 AA)   Lmo2   Pax-2a   HNF-4alpha2   HNF-4alpha1   AREB6   Egr-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWNT8A promoter sequence
   Search Chromatin IP Primers for WNT8A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WNT8A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q31.2   HGNC cytogenetic band: 5q31

WNT8A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT8A gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P137447:  view genomic region     (about GC identifiers)

Start:
137,419,581 bp from pter      End:
137,428,054 bp from pter
Size:
8,474 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: WNT8A_HUMAN, Q9H1J5 (See protein sequence)
Recommended Name: Protein Wnt-8a precursor  
Size: 351 amino acids; 38849 Da
Secondary accessions: Q96S51
Alternative splicing: 2 isoforms:  Q9H1J5-1   Q9H1J5-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for WNT8A: NX_Q9H1J5

Explore proteomics data for WNT8A at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn103, Asn262, Asn281

  • See WNT8A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_490645.1  
    ENSEMBL proteins: 
     ENSP00000426653   ENSP00000354726   ENSP00000424809   ENSP00000381739  
    Reactome Protein details: Q9H1J5

    WNT8A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for WNT8A
    OriGene Protein Over-expression Lysate for WNT8A
    OriGene MassSpec for WNT8A
    OriGene Custom Protein Services for WNT8A
    GenScript Custom Purified and Recombinant Proteins Services for WNT8A
    Novus Biologicals WNT8A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WNT8A

     
    Search eBioscience for Proteins for WNT8A 

     
    antibodies-online proteins for WNT8A (2 products) 

     
    antibodies-online peptides for WNT8A

    WNT8A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for WNT8A (Wnt-8a)
    OriGene Antibodies for WNT8A
    OriGene Custom Antibody Services for WNT8A
    Novus Biologicals WNT8A Antibodies
    Search for Antibodies for WNT8A at Abcam
    Cloud-Clone Corp. Antibodies for WNT8A
    ThermoFisher Antibodies for WNT8A
    antibodies-online antibodies for WNT8A (30 products) 

    WNT8A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for WNT8A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for WNT8A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for WNT8A
    Cloud-Clone Corp. CLIAs for WNT8A
    Search eBioscience for ELISAs for WNT8A 
    antibodies-online kits for WNT8A (5 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    WNT: Wingless-type MMTV integration sites

    3 InterPro protein domains:
     IPR013301 Wnt8
     IPR005817 Wnt
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry Q9H1J5

    ProtoNet protein and cluster: Q9H1J5

    1 Blocks protein domain: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WNT8A_HUMAN, Q9H1J5
    Similarity: Belongs to the Wnt family


    Find genes that share domains with WNT8A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WNT8A_HUMAN, Q9H1J5
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role
    in the development and differentiation of certain forebrain structures, notably the hippocampus

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005109frizzled binding NAS11408932
    GO:0005515protein binding ----
    GO:0048018receptor agonist activity NAS11408932
         
    Find genes that share ontologies with WNT8A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for WNT8A:
     Cell cycle / mitosis defect 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Wnt8a):
     hearing/vestibular/ear  normal 

    Find genes that share phenotypes with WNT8A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Wnt8atm1(KOMP)Vlcg for WNT8A

       genOway: Develop your customized and physiologically relevant rodent model for WNT8A

    miRNA
    Products:
        
    miRTarBase miRNAs that target WNT8A:
    hsa-mir-9-5p (MIRT021425)

    Block miRNA regulation of human, mouse, rat WNT8A using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate WNT8A:
    hsa-miR-147
    SwitchGear 3'UTR luciferase reporter plasmidWNT8A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for WNT8A
    Predesigned siRNA for gene silencing in human, mouse, rat WNT8A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for WNT8A

    Clone
    Products:
         
    OriGene clones in human, mouse for WNT8A (see all 6)
    OriGene ORF clones in mouse, rat for WNT8A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WNT8A (NM_058244)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WNT8A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT8A
    Addgene plasmids for WNT8A 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for WNT8A
    Browse ESI BIO Cell Lines and PureStem Progenitors for WNT8A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT8A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    WNT8A_HUMAN, Q9H1J5: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane3
    cytoskeleton1
    cytosol1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix ISS--
    GO:0005615colocalizes with extracellular space ISS--

    Find genes that share ontologies with WNT8A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for WNT8A About   (see all 19)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt Pathway
    Wnt Pathway0.56
    WNT ligand biogenesis and trafficking0.56
    2Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathways0.40
    3Basal cell carcinoma
    Basal cell carcinoma0.43
    Melanogenesis0.32
    Hedgehog signaling pathway0.43
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    GSK3 Signaling0.61


    Find genes that share SuperPaths with WNT8A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for WNT8A
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for WNT8A (see all 8)
        GSK3 Signaling
    Factors Promoting Cardiogenesis in Vertebrates
    Presenilin-Mediated Signaling
    Human Embryonic Stem Cell Pluripotency
    Colorectal Cancer Metastasis

    1 Tocris Bioscience Pathway for WNT8A
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT8A
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    1 BioSystems Pathway for WNT8A
        Neural Crest Differentiation

    4 Reactome Pathways for WNT8A
        disassembly of the destruction complex and recruitment of AXIN to the membrane
    WNT ligand biogenesis and trafficking
    TCF dependent signaling in response to WNT
    Class B/2 (Secretin family receptors)


    Selected Kegg Pathways  (Kegg details for WNT8A) (see all 8):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT8A: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for WNT8A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WNT8A (Q9H1J53 ENSP000003817394) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFRP1Q8N4743, ENSP000002207724I2D: score=1 STRING: ENSP00000220772
    CER1ENSP000003702974STRING: ENSP00000370297
    FZD10ENSP000002290304STRING: ENSP00000229030
    FZD3ENSP000002400934STRING: ENSP00000240093
    FZD6ENSP000003516054STRING: ENSP00000351605
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ----
    GO:0003002regionalization ----
    GO:0007275multicellular organismal development ----
    GO:0007492endoderm development IEA--
    GO:0009949polarity specification of anterior/posterior axis IEA--

    Find genes that share ontologies with WNT8A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WNT8A



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for WNT8A gene (2 alternative transcripts): 
    NM_058244.2  NM_031933.1  

    Unigene Cluster for WNT8A:

    Wingless-type MMTV integration site family, member 8A
    Hs.591274
    Unigene Representative Sequence: BC144497
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506684(uc011cyj.1 uc011cyk.1) ENST00000361560 ENST00000504809
    ENST00000398754(uc003lcd.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat WNT8A using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate WNT8A:
    hsa-miR-147
    SwitchGear 3'UTR luciferase reporter plasmidWNT8A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for WNT8A
    Predesigned siRNA for gene silencing in human, mouse, rat WNT8A
    Clone
    Products:
         
    OriGene clones in human, mouse for WNT8A (see all 6)
    OriGene ORF clones in mouse, rat for WNT8A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WNT8A (NM_058244)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WNT8A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT8A
    Addgene plasmids for WNT8A 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for WNT8A
    OriGene qSTAR qPCR primer pairs in human, mouse for WNT8A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WNT8A
      QuantiTect SYBR Green Assays in human, mouse, rat WNT8A
      QuantiFast Probe-based Assays in human, mouse, rat WNT8A

    Additional mRNA sequence: 

    AB057725.1 BC144001.1 BC144497.1 

    1 DOTS entry:

    DT.95148953 

    6 AceView cDNA sequences:

    NM_058244 AW663893 NM_031933 AB057725 AY009402 BQ428931 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for WNT8A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
    SP1:                                                
    SP2:                                                


    ECgene alternative splicing isoforms for WNT8A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    WNT8A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCAACCCAG
    WNT8A Expression
    About this image


    WNT8A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
             Epiblast Stem Cell line 5
     
     Primitive Streak (Early Embryonic Tissues)
             Primitive Streak Cells Primitive Streak
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
     
     Neural Tube (Nervous System)
             Telencephalon
    WNT8A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WNT8A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591274
        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT8A: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for WNT8A
    OriGene qSTAR qPCR primer pairs in human, mouse for WNT8A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WNT8A
    QuantiTect SYBR Green Assays in human, mouse, rat WNT8A
    QuantiFast Probe-based Assays in human, mouse, rat WNT8A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT8A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for WNT8A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wnt8a1 , 5 wingless-related MMTV integration site 8A1, 5 83.86(n)1
    81.09(a)1
      18 (18.69 cM)5
    208901  NM_009290.21  NP_033316.11 
     345423285 
    chicken
    (Gallus gallus)
    Aves WNT8A1 wingless-type MMTV integration site family, member more 72.53(n)
    72.33(a)
      396543  NM_205531.1  NP_990862.1 
    lizard
    (Anolis carolinensis)
    Reptilia WNT8A6
    wingless-type MMTV integration site family, member...
    68(a)
    1 ↔ 1
    2(142098490-142104836)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xwnt-82 X.laevis Xwnt-8 mRNA 73.83(n)    X57234.1 
    zebrafish
    (Danio rerio)
    Actinopterygii NM_130946.12   -- 74.32(n)   30122  NM_130946.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Wnt46
    Wnt oncogene analog 4
    17(a)
    many ↔ many
    2L(7255460-7277168)
    worm
    (Caenorhabditis elegans)
    Secernentea egl-206
    Protein EGL-20 (egl-20) mRNA, complete cds
    28(a)
    many ↔ many
    IV(9812444-9815526) WBGene00001188


    ENSEMBL Gene Tree for WNT8A (if available)
    TreeFam Gene Tree for WNT8A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for WNT8A gene
    WNT8B2  WNT10B2  WNT9B2  WNT10A2  WNT9A2  
    16 SIMAP similar genes for WNT8A using alignment to 3 protein entries:     WNT8A_HUMAN (see all proteins):
    WNT8B    WNT2B    WNT5B    WNT7B    WNT2    WNT5A
    WNT16    WNT7A    WNT4    WNT1    WNT3    WNT3A
    WNT9B    WNT11    WNT6    WNT9A

    Find genes that share paralogs with WNT8A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for WNT8A (see all 243)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs48357611,2
    C,F,A,H--137417869(+) CTTTTG/ATTCTA 1 -- us2k124Minor allele frequency- A:0.46NS EA NA WA CSA 2532
    rs1426275391,2
    --137417935(+) CATCCA/GGGTGC 1 -- us2k10--------
    rs1835388901,2
    C--137418065(+) GGAGTC/TTGAGA 1 -- us2k10--------
    rs112424161,2
    C,F,A--137418317(+) TAATCG/CCAGCA 1 -- us2k15Minor allele frequency- C:0.30NA CSA 10
    rs1121833051,2
    C--137418411(+) AAATAC/TAAAAA 1 -- us2k10--------
    rs1860781671,2
    C--137418543(+) CCTGGC/TGACAG 1 -- us2k10--------
    rs106900191,2
    C--137418601(+) taaat-/AAATA/
    AAATAAAT
    aaata
    1 -- us2k1 tfbs30--------
    rs666480311,2
    C--137418605(+) ATAAA-/A/TA  
      AATAAA
    TAAAA
    1 -- us2k10--------
    rs1412494121,2
    C--137418959(+) AGCGAA/GAGACT 1 -- us2k10--------
    rs58716641,2
    C--137418972(+) GTCTC-/AAAAAA 1 -- us2k1 trp30--------

    HapMap Linkage Disequilibrium report for WNT8A (137419581 - 137428054 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for WNT8A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830502CNV Gain17160897

    Human Gene Mutation Database (HGMD): WNT8A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WNT8A
    DNA2.0 Custom Variant and Variant Library Synthesis for WNT8A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606360    OMIM disorders: --

    1 disease for WNT8A:    
    About MalaCards
    germ cell tumors

    1 disease from the University of Copenhagen DISEASES database for WNT8A:
    Cleft lip

    Find genes that share disorders with WNT8A           About GenesLikeMe

    Genetic Association Database (GAD): WNT8A
    Human Genome Epidemiology (HuGE) Navigator: WNT8A (3 documents)

    Export disorders for WNT8A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for WNT8A gene integrated from 10 sources:
    (articles sorted by number of sources associating them with WNT8A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of human WNT8A. (PubMed id 11408932)1, 2, 3 Saitoh T. and Katoh M. (Int. J. Oncol. 2001)
    2. Studies with Wnt genes and nonsyndromic cleft lip and palate. (PubMed id 20890934)1, 4 Menezes R....Vieira A.R. (Birth Defects Res. Part A Clin. Mol. Teratol. 2010)
    3. Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate. (PubMed id 18413325)1, 4 Chiquet B.T....Hecht J.T. (Hum. Mol. Genet. 2008)
    4. Meta-analysis identifies six new susceptibility loci for atrial fibrillation. (PubMed id 22544366)1 Ellinor P.T....KAoAob S. (Nat. Genet. 2012)
    5. Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)1 Guo Z....Gao Y. (J. Proteome Res. 2012)
    6. Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines: up-regulation of WNT8B mRNA by beta-estradiol in MCF-7 cells, and down-regulation of WNT8A and WNT8B mRNAs by retinoic acid in NT2 cells. (PubMed id 11956596)1 Saitoh T....Katoh M. (Int. J. Oncol. 2002)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Wnt family proteins are secreted and associated with the cell surface. (PubMed id 8167409)1 Smolich B.D....Papkoff J. (Mol. Biol. Cell 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7478 HGNC: 12788 AceView: WNT8A Ensembl:ENSG00000061492 euGenes: HUgn7478
    ECgene: WNT8A Kegg: 7478 H-InvDB: WNT8A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for WNT8A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT8A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for WNT8A gene:
    Search GeneIP for patents involving WNT8A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for WNT8A (Wnt-8a)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for WNT8A   OriGene RNAi products in human, mouse, rat for WNT8A  
     OriGene qPCR primer pairs and template standards for WNT8A   OriGene Protein Over-expression Lysate for WNT8A  
     OriGene MassSpec for WNT8A   OriGene clones in human, mouse for WNT8A  
     OriGene qSTAR qPCR primer pairs in human, mouse for WNT8A   OriGene Purified Protein for WNT8A  
     OriGene ORF clones in mouse, rat for WNT8A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for WNT8A   OriGene Custom Protein Services for WNT8A  

     
     
     Block miRNA regulation of human, mouse, rat WNT8A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing WNT8A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WNT8A Predesigned siRNA for gene silencing in human, mouse, rat WNT8A
     QuantiFast Probe-based Assays in human, mouse, rat WNT8A QuantiTect SYBR Green Assays in human, mouse, rat WNT8A
     PCR Arrays including human, mouse, rat WNT8A Search Chromatin IP Primers for WNT8A
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WNT8A  Search GeneGlobe Interaction Network for WNT8A
     Regulatory tfbs in WNT8A promoter
     GenScript Custom Purified and Recombinant Proteins Services for WNT8A GenScript cDNA clones with any tag delivered in your preferred vector for WNT8A
     GenScript Custom Assay Services for WNT8A GenScript Custom overexpressing Cell Line Services for WNT8A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for WNT8A
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     WNT8A antibodies
     WNT8A lysates
     Search for Antibodies for WNT8A at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for WNT8A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for WNT8A
     Antibodies for WNT8A
     ELISAs for WNT8A
     CLIAs for WNT8A



     Browse ESI BIO Cell Lines and PureStem Progenitors for WNT8A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT8A
     SwitchGear 3'UTR luciferase reporter plasmids for WNT8A
     SwitchGear Promoter luciferase reporter plasmids for WNT8A
     ThermoFisher Antibodies for WNT8A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT8A
     Browse compounds at ApexBio
     Addgene plasmids for WNT8A
      Search eBioscience for proteins for WNT8A
      Search eBioscience for elisas for WNT8A
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for WNT8A
     antibodies-online antibodies for WNT8A (30 products)
     antibodies-online kits for WNT8A (5 products)
     antibodies-online peptides for WNT8A
     antibodies-online proteins for WNT8A (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      WNT8A gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4