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Aliases for WNT8A Gene

Aliases for WNT8A Gene

  • Wnt Family Member 8A 2 3
  • Wingless-Type MMTV Integration Site Family, Member 8A 2 3
  • Wingless-Type MMTV Integration Site Family Member 8A 3 5
  • Protein Wnt-8d 3 4
  • WNT8d 3 4

External Ids for WNT8A Gene

Previous GeneCards Identifiers for WNT8A Gene

  • GC05P137294
  • GC05P137450
  • GC05P137495
  • GC05P137447
  • GC05P132610

Summaries for WNT8A Gene

Entrez Gene Summary for WNT8A Gene

  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and may be implicated in development of early embryos as well as germ cell tumors. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for WNT8A Gene

WNT8A (Wnt Family Member 8A) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Pathways in cancer. GO annotations related to this gene include receptor binding and receptor agonist activity. An important paralog of this gene is WNT8B.

UniProtKB/Swiss-Prot for WNT8A Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT8A Gene

Genomics for WNT8A Gene

Regulatory Elements for WNT8A Gene

Genomic Location for WNT8A Gene

Chromosome:
5
Start:
138,083,892 bp from pter
End:
138,096,730 bp from pter
Size:
12,839 bases
Orientation:
Plus strand

Genomic View for WNT8A Gene

Genes around WNT8A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNT8A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNT8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT8A Gene

Proteins for WNT8A Gene

  • Protein details for WNT8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1J5-WNT8A_HUMAN
    Recommended name:
    Protein Wnt-8a
    Protein Accession:
    Q9H1J5
    Secondary Accessions:
    • Q96S51

    Protein attributes for WNT8A Gene

    Size:
    351 amino acids
    Molecular mass:
    38849 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WNT8A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WNT8A Gene

Proteomics data for WNT8A Gene at MOPED

Post-translational modifications for WNT8A Gene

  • Palmitoleylation is required for efficient binding to frizzled receptors (By similarity). Depalmitoleylation leads to Wnt signaling pathway inhibition (By similarity).
  • Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT8A.
  • Glycosylation at Asn 103, Asn 262, and Asn 281
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT8A Gene

No data available for DME Specific Peptides for WNT8A Gene

Domains & Families for WNT8A Gene

Gene Families for WNT8A Gene

Protein Domains for WNT8A Gene

Suggested Antigen Peptide Sequences for WNT8A Gene

Graphical View of Domain Structure for InterPro Entry

Q9H1J5

UniProtKB/Swiss-Prot:

WNT8A_HUMAN :
  • Belongs to the Wnt family.
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT8A: view

Function for WNT8A Gene

Molecular function for WNT8A Gene

UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.

Gene Ontology (GO) - Molecular Function for WNT8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
GO:0048018 receptor agonist activity NAS 11408932
genes like me logo Genes that share ontologies with WNT8A: view
genes like me logo Genes that share phenotypes with WNT8A: view

Animal Models for WNT8A Gene

MGI Knock Outs for WNT8A:

Animal Model Products

miRNA for WNT8A Gene

miRTarBase miRNAs that target WNT8A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WNT8A Gene

Localization for WNT8A Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT8A Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WNT8A Gene COMPARTMENTS Subcellular localization image for WNT8A gene
Compartment Confidence
extracellular 5
cytosol 2
plasma membrane 2
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for WNT8A Gene

Pathways & Interactions for WNT8A Gene

genes like me logo Genes that share pathways with WNT8A: view

SIGNOR curated interactions for WNT8A Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for WNT8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003002 regionalization IEA --
GO:0007275 multicellular organism development IEA --
GO:0007492 endoderm development IEA --
GO:0009949 polarity specification of anterior/posterior axis IEA --
GO:0010085 polarity specification of proximal/distal axis IEA --
genes like me logo Genes that share ontologies with WNT8A: view

Drugs & Compounds for WNT8A Gene

No Compound Related Data Available

Transcripts for WNT8A Gene

mRNA/cDNA for WNT8A Gene

(5) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for WNT8A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1:
SP2:

Relevant External Links for WNT8A Gene

GeneLoc Exon Structure for
WNT8A
ECgene alternative splicing isoforms for
WNT8A

Expression for WNT8A Gene

mRNA expression in normal human tissues for WNT8A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT8A Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x8.5), Brain - Nucleus accumbens (basal ganglia) (x7.8), Brain - Caudate (basal ganglia) (x6.6), and Testis (x6.1).

Protein differential expression in normal tissues from HIPED for WNT8A Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WNT8A Gene



SOURCE GeneReport for Unigene cluster for WNT8A Gene Hs.591274

genes like me logo Genes that share expression patterns with WNT8A: view

Protein tissue co-expression partners for WNT8A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for WNT8A Gene

Orthologs for WNT8A Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT8A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WNT8A 35
  • 88.79 (n)
  • 91.17 (a)
WNT8A 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WNT8A 35
  • 89.74 (n)
  • 91.74 (a)
WNT8A 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wnt8a 35
  • 83.86 (n)
  • 81.09 (a)
Wnt8a 16
Wnt8a 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WNT8A 35
  • 99.43 (n)
  • 99.43 (a)
WNT8A 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wnt8a 35
  • 84.53 (n)
  • 82.13 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 20 (a)
ManyToMany
chicken
(Gallus gallus)
Aves WNT8A 35
  • 72.53 (n)
  • 72.33 (a)
WNT8C 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WNT8A 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15027 35
wnt8a 35
  • 71.35 (n)
  • 74.27 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xwnt-8 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
wnt8a 35
  • 68.09 (n)
  • 70.52 (a)
wnt8a 36
  • 60 (a)
OneToMany
wnt8a 36
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Wnt4 36
  • 17 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea egl-20 36
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
ManyToMany
Species with no ortholog for WNT8A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT8A Gene

ENSEMBL:
Gene Tree for WNT8A (if available)
TreeFam:
Gene Tree for WNT8A (if available)

Paralogs for WNT8A Gene

Paralogs for WNT8A Gene

(16) SIMAP similar genes for WNT8A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with WNT8A: view

Variants for WNT8A Gene

Sequence variations from dbSNP and Humsavar for WNT8A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs172607 -- 138,086,398(+) ttttt(A/T)gtaga intron-variant
rs217254 -- 138,091,875(+) AATAA(A/C)TAATA intron-variant, downstream-variant-500B
rs217255 -- 138,091,988(+) AAAGG(C/G)AATCA intron-variant, downstream-variant-500B
rs217256 -- 138,095,812(+) GAGAT(C/T)GCAGA intron-variant
rs217267 -- 138,085,585(+) GAACC(A/G)TGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WNT8A Gene

Variant ID Type Subtype PubMed ID
nsv830502 CNV Gain 17160897

Variation tolerance for WNT8A Gene

Residual Variation Intolerance Score: 65.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WNT8A Gene

HapMap Linkage Disequilibrium report
WNT8A
Human Gene Mutation Database (HGMD)
WNT8A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT8A Gene

Disorders for WNT8A Gene

Relevant External Links for WNT8A

Genetic Association Database (GAD)
WNT8A
Human Genome Epidemiology (HuGE) Navigator
WNT8A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WNT8A

No disorders were found for WNT8A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WNT8A Gene

Publications for WNT8A Gene

  1. Molecular cloning and characterization of human WNT8A. (PMID: 11408932) Saitoh T. … Katoh M. (Int. J. Oncol. 2001) 2 3 4 67
  2. Polymorphisms and expression of the WNT8A gene in Hirschsprung's disease. (PMID: 23836442) Gao H. … Wang W. (Int. J. Mol. Med. 2013) 3
  3. Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. (PMID: 22889411) Guo Z. … Gao Y. (J. Proteome Res. 2012) 3
  4. Meta-analysis identifies six new susceptibility loci for atrial fibrillation. (PMID: 22544366) Ellinor P.T. … KAoAob S. (Nat. Genet. 2012) 3
  5. Endogenous Wnt/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells. (PMID: 20559569) Paige S.L. … Murry C.E. (PLoS ONE 2010) 3

Products for WNT8A Gene

Sources for WNT8A Gene

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