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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WNT7B Gene

protein-coding   GIFtS: 62
GCID: GC22M046316

wingless-type MMTV integration site family, member 7B
 Explore 13 diseases affiliated with
WNT7B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for WNT7B    

Aliases
for WNT7B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Wingless-Type MMTV Integration Site Family, Member 7B1 2
Protein Wnt-7b2

External Ids:    HGNC: 127871   Entrez Gene: 74772   Ensembl: ENSG000001880647   OMIM: 6019675   UniProtKB: P567063   

Export aliases for WNT7B gene to outside databases

Previous GC identifers: GC22U990050 GC03M013836 GC00M9P0021 GC22M044638 GC22M029261


Summaries
for WNT7B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for WNT7B:
This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted
signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes,
including regulation of cell fate and patterning during embryogenesis. Among members of the human WNT family, this
gene product is most similar to WNT7A protein. (provided by RefSeq, Oct 2008)

UniProtKB/Swiss-Prot: WNT7B_HUMAN, P56706
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein.
May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over
only few cell diameters (By similarity)

Gene Wiki entry for WNT7B


Genomic Views
for WNT7B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WNT7B gene promoter:
         RFX1   Pax-5   Egr-1   MyoD   LCR-F1   GATA-1   AREB6   HEN1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WNT7B promoter sequence
   Search SABiosciences Chromatin IP Primers for WNT7B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WNT7B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13   Ensembl cytogenetic band:  22q13.31   HGNC cytogenetic band: 22q13

WNT7B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT7B gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M046316:  view genomic region     (about GC identifiers)

Start:
 46,316,242 bp from pter      End:
 46,373,009 bp from pter
Size:
 56,768 bases      Orientation:
 minus strand

Proteins
for WNT7B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: WNT7B_HUMAN, P56706 (See protein sequence)
Recommended Name: Protein Wnt-7b precursor  
Size: 349 amino acids; 39327 Da
Subunit: Interacts with PORCN (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix
Secondary accessions: B8A596 Q96Q12

Explore the universe of human proteins at neXtProt for WNT7B: NX_P56706

Post-translational modifications:

  • Palmitoylation at Ser-206 is required for efficient binding to frizzled receptors. It is also required for subsequent
    • palmitoylation at Cys-73. Palmitoylation is necessary for proper trafficking to cell surface (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P56706

    • WNT7B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_478679.1  
    ENSEMBL proteins: 
     ENSP00000341032   ENSP00000386781   ENSP00000386546   ENSP00000387217   ENSP00000392750  
    Reactome Protein details: P56706
    Human Recombinant Protein Products: 
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    Novus Biologicals WNT7B Proteins
    Novus Biologicals WNT7B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for WNT7B

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IBA--
    GO:0005886plasma membrane IBA--


    WNT7B for ontologies           About GeneDecksing



    WNT7B Antibody Products: 
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    Uscn ELISAs and CLIAs for WNT7B

    Protein Domains /
    Families
    for WNT7B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    WNT7B for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR013300 Wnt7
     IPR005817 Wnt
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry P56706

    ProtoNet protein and cluster: P56706

    1 Blocks protein family: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WNT7B_HUMAN, P56706
    Similarity: Belongs to the Wnt family


    Function
    for WNT7B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: WNT7B_HUMAN, P56706
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein.
    May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over
    only few cell diameters (By similarity)

         Genatlas biochemistry entry for WNT7B:
    wingless-type MMTV integration site 7B,Drosophila wingless (wg) segment polarity gene homolog,expressed in specific
    region of the forebrain,the kidney and the limb ectoderm,modulating cell fate and cell behavior during vertebrate
    development

         Summary:  
    During embryonic development, WNT7B as signaling molecule
    affects the following cells: Distal Mesodermal Progenitor Cells in Lung Mesoderm

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WNT7B
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate WNT7B (see all 23):
    hsa-miR-3130-5p hsa-miR-30c hsa-miR-3607-3p hsa-miR-4254 hsa-miR-765 hsa-miR-30d hsa-miR-410 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmid: WNT7B 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WNT7B (see all 7)
    OriGene shRNA RFP: WNT7B
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: WNT7B (NM_058238)
    Sino Biological Human cDNA Clone for WNT7B
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT7B 

    Cell Line
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    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT7B

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005109frizzled binding IBA--
    GO:0005201extracellular matrix structural constituent NAS--


    WNT7B for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for WNT7B:
     Increased gamma-H2AX phosphory  Wnt reporter downregulated 

    Animal Models:
         Mouse knock-outs for WNT7B: Wnt7btm2.1Amc Wnt7btm1Parr
         11 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Wnt7b):
     cardiovascular system  cellular  embryogenesis  homeostasis/metabolism  mortality/aging 
     nervous system  no phenotypic analysis  renal/urinary system  respiratory system  skeleton 
     vision/eye 

    WNT7B for phenotypes           About GeneDecksing


    Pathways & Interactions
    for WNT7B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Wnt Signaling Pathway
    		Wnt Signaling Pathway1.00
    		Wnt Signaling Pathway0.33
    		Wnt Signaling Pathway and Pluripotency0.55
    		Wnt signaling pathway0.30
    		DNA damage response (only ATM dependent)0.35
    2Basal cell carcinoma
    		Basal cell carcinoma1.00
    		Wnt Pathway0.37
    		Hedgehog signaling pathway0.41
    		Melanogenesis0.32
    3Translation_Non-genomic (rapid) action of Androgen Receptor
    		Translation_Non-genomic (rapid) action of Androgen Receptor1.00
    		Translation Non-genomic (rapid) action of Androgen Receptor0.99
    4Transcription_Androgen Receptor nuclear signaling
    		Transcription_Androgen Receptor nuclear signaling1.00
    		Transcription Androgen Receptor nuclear signaling0.99
    5Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency1.00
    		GSK3 Signaling0.61

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for WNT7B
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    1 R&D Systems Pathway for WNT7B
        Wnt Signaling Pathway

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for WNT7B (see all 7)
        GSK3 Signaling
    Presenilin-Mediated Signaling
    Colorectal Cancer Metastasis
    Human Embryonic Stem Cell Pluripotency
    Nanog in Mammalian ESC Pluripotency

    1 Tocris Bioscience Pathway for WNT7B
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT7B
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    4 BioSystems Pathways for WNT7B 
        DNA damage response (only ATM dependent)
    Wnt Signaling Pathway and Pluripotency
    Wnt Signaling Pathway
    Wnt signaling network

    4        Reactome Pathways for WNT7B
        Signal Transduction
    Signaling by GPCR
    GPCR ligand binding
    Class B/2 (Secretin family receptors)


    5         Kegg Pathways  (Kegg details for WNT7B):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Melanogenesis
    Pathways in cancer
    Basal cell carcinoma


    WNT7B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WNT7B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/25 Interacting proteins for WNT7B (P567063 ENSP000003410324) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FZD1Q9UP383, ENSP000002879344I2D: score=2 STRING: ENSP00000287934
    FZD10Q9ULW23, ENSP000002290304I2D: score=1 STRING: ENSP00000229030
    FZD5Q134673, ENSP000003546074I2D: score=1 STRING: ENSP00000354607
    GPC3P516543, ENSP000003598544I2D: score=1 STRING: ENSP00000359854
    LRP5O751973, ENSP000002943044I2D: score=1 STRING: ENSP00000294304
    About this table

    Gene Ontology (GO): 5/51 biological process terms (GO ID links to tree view) (see all 51):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development ISS--
    GO:0001944vasculature development ----
    GO:0003338metanephros morphogenesis ISS--
    GO:0006917induction of apoptosis IEA--
    GO:0007257activation of JUN kinase activity IBA--


    WNT7B for ontologies           About GeneDecksing



    Drugs & Compounds
    for WNT7B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for WNT7B:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WNT7B
    Search CenterWatch for drugs/clinical trials and news about WNT7B 

    Transcripts
    for WNT7B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for WNT7B gene: 
    NM_058238.2  

    Unigene Cluster for WNT7B:

    Wingless-type MMTV integration site family, member 7B
    Hs.512714  [show with all ESTs]
    Unigene Representative Sequence: NM_058238
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000339464(uc010haa.2 uc003bgo.2) ENST00000410089 ENST00000409496
    ENST00000410058 ENST00000428540

    miRNA
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    hsa-miR-3130-5p hsa-miR-30c hsa-miR-3607-3p hsa-miR-4254 hsa-miR-765 hsa-miR-30d hsa-miR-410 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmid: WNT7B 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: WNT7B
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB062766.1 AF416743.1 AK123019.1 AK289526.1 BC034923.1 

    4 DOTS entries:

    DT.97855930  DT.99978339  DT.92024632  DT.120642967 

    24/117 AceView cDNA sequences (see all 117):

    AI904944 CB853639 BQ953369 BE795833 BU738297 BM670301 BU185530 BU684896 
    AW294903 BU737957 BU684701 BU191265 BU620489 BU737516 AW298373 BU740827 
    CD635675 BU615708 BM727271 AI203859 CA450047 BM712028 AI623657 CD676047 

    GeneLoc Exon Structure


    Expression
    for WNT7B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WNT7B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    WNT7B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/21 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 21) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainSubstantia Nigra pars CompactaAdult Dopaminergic NeuronsDopaminergic neurons
    BrainSubstantia Nigra pars CompactaEmbryonic Dopaminergic NeuronsDopaminergic neurons
    BrainVentral Tegmental AreaAdult Dopaminergic NeuronsDopaminergic neurons
    BrainVentral Tegmental AreaEmbryonic Dopaminergic NeuronsDopaminergic neurons
    KidneyRenal Collecting Duct SystemCollecting Duct CellsKidney
    LungLung BudLung Bud Progenitor CellsLung
    KidneyLoop of HenleLoop of Henle CellsKidney
    BrainFourth VentricleBrain
    BrainHypothalamusBrain
    BrainThalamusBrain
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Endothelial cells and neural cells (Derivation of blood-...)

    See WNT7B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WNT7B

    SOURCE GeneReport for Unigene cluster: Hs.512714

    UniProtKB/Swiss-Prot: WNT7B_HUMAN, P56706
    Tissue specificity: Moderately expressed in fetal brain, weakly expressed in fetal lung and kidney, and faintly
    expressed in adult brain, lung and prostate

        SABiosciences Expression via Pathway-Focused PCR Arrays including WNT7B: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for WNT7B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for WNT7B gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves WNT7B1 wingless-type MMTV integration site family, member more 80.13(n)
    95.42(a)    		   427937  NM_001037274.1  NP_001032351.1 
    lizard
    (Anolis carolinensis)    		 Reptilia WNT7B6
    		 --
    		 91(a)
    		 1 ↔ 1
    		 5(83934076-83970728)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.2292 Xenopus laevis Wnt7B (Xwnt7B) mRNA, complete cds 80.54(n)    AF026894.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wnt7bb1 wingless-type MMTV integration site family, member more 79.22(n)
    91.05(a)    		   100148840  XM_001920184.3  XP_001920219.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Wnt21 , 3 frizzled-2 receptor signaling pathway signal
    transducer3
    Wnt oncogene analog 21    		 51(a)
    (best of 3)3
    60.4(n)1
    53.18(a)1    		   45E13
    359751  NM_057462.31  NP_476810.11 


    ENSEMBL Gene Tree for WNT7B (if available)
    TreeFam Gene Tree for WNT7B (if available) 

    Paralogs
    for WNT7B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WNT7B gene
    WNT5B2  WNT162  WNT62  WNT5A2  WNT112  WNT22  WNT2B2  WNT3A2  
    WNT12  WNT10B2  WNT42  WNT7A2  WNT10A2  WNT32  
    18 SIMAP similar genes for WNT7B using alignment to 5 protein entries:     WNT7B_HUMAN (see all proteins):
    WNT7A    WNT2    WNT5B    WNT2B    WNT5A    WNT3
    WNT3A    WNT4    WNT1    WNT8A    WNT11    WNT16
    WNT9B    WNT9A    WNT6    WNT8B    WNT10B    WNT10A

    WNT7B for paralogs           About GeneDecksing



    Genomic Variants
    for WNT7B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1415 NCBI SNPs in WNT7B are shown (see all 1415)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs286634661,2
    		C,F,H,--46316057(+) TCTCAG/AGGGTG 1 -- ds500120Minor allele frequency- A:0.40NS EA WA NA CSA 2344
    rs1885958591,2
    		--46316132(+) CCAGAC/TAGCTG 1 -- ds50010--------
    rs285265091,2
    		C,--46316150(+) ATGAAG/CGCCTC 1 -- ds50014Minor allele frequency- C:0.14WA NA EA 360
    rs768004331,2
    		F,--46316155(+) GGCCTC/TGGGGG 1 -- ds50013Minor allele frequency- T:0.05WA NA EA 358
    rs734571351,2
    		C,--46316164(+) GGCTCG/ATCCTG 1 -- ds50012Minor allele frequency- A:0.13CSA WA 120
    rs566864761,2
    		--46316331(+) TGGTCA/GCCATC 1 -- ut310--------
    rs784373341,2
    		F,--46316424(+) AGTGGG/AGTGCC 1 -- ut311Minor allele frequency- A:0.07NA 120
    rs1133431861,2
    		C,F,--46316508(+) TGGTTC/TGGGAG 1 -- ut311Minor allele frequency- T:0.10NA 120
    rs1491779971,2
    		--46316567(+) GGATGA/GGGGAT 1 -- ut310--------
    rs1932752661,2
    		--46316576(+) ATGGGA/GTCAGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for WNT7B (46316242 - 46373009 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for WNT7B
         2 Indels: 12269 41387

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    Disorders / Diseases
    for WNT7B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    WNT7B for disorders           About GeneDecksing

    OMIM gene information: 601967    OMIM disorders: --

    13 diseases for WNT7B:    About MalaCards
    basal cell carcinoma    chronic lymphocytic leukemia    lymphocytic leukemia    fainting
    endometrial carcinoma    hermaphroditism    hepatocellular carcinoma    leukemia
    carcinoma    melanoma    prostatitis    neuronitis
    colorectal cancer

    3 Novoseek disease relationships for WNT7B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatic cancer 25.4 1 11562755 (1)
    breast cancer 4.36 1 9367869 (1)
    cancer 0 1 11562755 (1)

    Human Genome Epidemiology (HuGE) Navigator: WNT7B (1 document)

    Export disorders for WNT7B gene to outside databases

    Publications
    for WNT7B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WNT7B gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with WNT7B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of human WNT7B. (PubMed id 11562755)1, 2, 3, 9 Kirikoshi H....Katoh M. (2001)
    2. Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. (PubMed id 8168088)1, 2, 3, 9 Huguet E.L.... Harris A.L. (1994)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Assignment of WNT7B to human chromosome band 22q13 by in situ hybridization. (PubMed id 9284940)1, 3 van Bokhoven H....Brunner H.G. (1997)
    5. Expression patterns of Wnt genes during development of an anterior part of the chicken eye. (PubMed id 16258938)1, 9 Fokina V.M. and Frolova E.I. (2006)
    6. Mesenchymal stem cells produce Wnt isoforms and TGF-b eta1 that mediate proliferation and procollagen expression by lung fibroblasts. (PubMed id 19734317)1, 9 Salazar K.D....Brody A.R. (2009)
    7. Wnt ligands signal in a cooperative manner to promote foregut organogenesis. (PubMed id 22949635)1 Miller M.F....Morrisey E.E. (2012)
    8. Wnt signaling and Dupuytren's disease. (PubMed id 21732829)1 Dolmans G.H.... . (2011)
    9. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1 Jugessur A....Murray J.C. (2010)
    10. Variation in WNT genes expression in different subtyp es of chronic lymphocytic leukemia. (PubMed id 19863181)1 Memarian A....Shokri F. (2009)

    External Searches for WNT7B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing WNT7B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7477 HGNC: 12787 AceView: WNT7B Ensembl:ENSG00000188064 euGenes: HUgn7477
    ECgene: WNT7B Kegg: 7477 H-InvDB: WNT7B

    Other Databases showing WNT7B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing WNT7B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WNT7B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT7B Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for WNT7B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for WNT7B gene:
    Search GeneIP for patents involving WNT7B

    GeneCards and IP:
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