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WNT7A Gene

protein-coding   GIFtS: 70
GCID: GC03M013835

Wingless-Type MMTV Integration Site Family, Member 7A

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Wingless-Type MMTV Integration Site Family, Member 7A1 2
Proto-Oncogene Wnt7a Protein1 2
Protein Wnt-7a2

External Ids:    HGNC: 127861   Entrez Gene: 74762   Ensembl: ENSG000001547647   OMIM: 6015705   UniProtKB: O007553   

Export aliases for WNT7A gene to outside databases

Previous GC identifers: GC03M013789 GC03M013851


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WNT7A Gene:
This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted
signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes,
including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development
of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth
muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann
and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. (provided by RefSeq, Jul 2008)

GeneCards Summary for WNT7A Gene:
WNT7A (wingless-type MMTV integration site family, member 7A) is a protein-coding gene. Diseases associated with WNT7A include fuhrmann syndrome, and ulna and fibula absence of with severe limb deficiency. GO annotations related to this gene include frizzled binding and receptor binding. An important paralog of this gene is WNT5B.

UniProtKB/Swiss-Prot: WNT7A_HUMAN, O00755
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental
protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts (By similarity)

Gene Wiki entry for WNT7A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the WNT7A gene promoter:
         N-Myc   PPAR-gamma1   Pax-5   PPAR-gamma2   E47   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWNT7A promoter sequence
   Search Chromatin IP Primers for WNT7A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WNT7A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25   Ensembl cytogenetic band:  3p25.1   HGNC cytogenetic band: 3p25

WNT7A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT7A gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M013835:  view genomic region     (about GC identifiers)

Start:
13,857,755 bp from pter      End:
13,921,618 bp from pter
Size:
63,864 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: WNT7A_HUMAN, O00755 (See protein sequence)
Recommended Name: Protein Wnt-7a precursor  
Size: 349 amino acids; 39005 Da
Subunit: Interacts with PORCN (By similarity)
Secondary accessions: Q96H90 Q9Y560

Explore the universe of human proteins at neXtProt for WNT7A: NX_O00755

Explore proteomics data for WNT7A at MOPED

Post-translational modifications: 

  • Palmitoylation at Ser-206 is required for efficient binding to frizzled receptors. It is also required for
    subsequent palmitoylation at Cys-73. Palmitoylation is necessary for proper trafficking to cell surface (By
    similarity)1
  • Glycosylation2 at Asn83, Asn127, Asn295
  • Modification sites at PhosphoSitePlus

  • See WNT7A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004616.2  
    ENSEMBL proteins: 
     ENSP00000285018  
    Reactome Protein details: O00755

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WNT: Wingless-type MMTV integration sites

    3 InterPro protein domains:
     IPR013300 Wnt7
     IPR005817 Wnt
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry O00755

    ProtoNet protein and cluster: O00755

    1 Blocks protein domain: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WNT7A_HUMAN, O00755
    Similarity: Belongs to the Wnt family


    WNT7A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WNT7A_HUMAN, O00755
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental
    protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts (By similarity)

         Genatlas biochemistry entry for WNT7A:
    wingless-type MMTV integration site 7A,Drosophila wingless (Wg) segment polarity gene homolog,controlling limb
    development at the dorsoventral axis,modulating cell fate and cell behavior during vertebrate development,
    upregulating LMX1A expression in limbs mesenchyme and dorsal differentiation

         Summary: 
    During embryonic development, WNT7A as signaling molecule is secreted from the following cells:
                
    Limb: Apical Ectodermal Ridge Cells (Limb Ectoderm)
    Surface Ectoderm: Surface Ectoderm Cells (Surface Ectoderm)

    It affects the following cells:       fully expand
    Limb: Prechondrocytic Mesenchymal Cells (Autopod), Zone Of Polarizing Activity Cells (Zeugopod)      fully expand to see all 4 cells

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI12857724
    GO:0005109frizzled binding IBA--
    GO:0005125cytokine activity IDA18986540
    GO:0005515protein binding ----
    GO:0048018receptor agonist activity IDA18986540
         
    WNT7A for ontologies           About GeneDecksing


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Wnt7a):
     behavior/neurological  cardiovascular system  embryogenesis  hearing/vestibular/ear  integument 
     limbs/digits/tail  mortality/aging  nervous system  normal  reproductive system 
     skeleton  vision/eye 

    WNT7A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Wnt7atm1Amc for WNT7A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WNT7A
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WNT7A
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate WNT7A (see all 16):
    hsa-miR-361-5p hsa-miR-137 hsa-miR-922 hsa-miR-15a hsa-miR-497 hsa-miR-3190 hsa-miR-520a-5p hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidWNT7A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat WNT7A

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT7A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WNT7A_HUMAN, O00755: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    mitochondrion3
    plasma membrane3
    cytosol2
    golgi apparatus2
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IBA--
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005796Golgi lumen TAS--

    WNT7A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WNT7A About   (see all 20)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathways0.40
    2Wnt Pathway
    Wnt Pathway0.56
    WNT ligand biogenesis and trafficking0.56
    3Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway0.55
    DNA damage response (only ATM dependent)0.32
    Wnt Signaling Pathway and Pluripotency0.55
    4Basal cell carcinoma
    Basal cell carcinoma0.43
    Melanogenesis0.32
    Hedgehog signaling pathway0.43
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for WNT7A
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for WNT7A (see all 7)
        GSK3 Signaling
    Presenilin-Mediated Signaling
    Colorectal Cancer Metastasis
    Human Embryonic Stem Cell Pluripotency
    Nanog in Mammalian ESC Pluripotency

    1 Tocris Bioscience Pathway for WNT7A
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT7A
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    5 BioSystems Pathways for WNT7A
        Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    DNA damage response (only ATM dependent)
    Wnt Signaling Pathway NetPath
    Wnt signaling network


    2 Reactome Pathways for WNT7A
        WNT ligand biogenesis and trafficking
    Class B/2 (Secretin family receptors)


    Selected Kegg Pathways  (Kegg details for WNT7A) (see all 8):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection


    WNT7A for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT7A: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for WNT7A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WNT7A (O007552, 3 ENSP000002850184) via UniProtKB, MINT, STRING, and/or I2D (see all 94)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STRN4Q9NRL32, 3MINT-65611 I2D: score=4 
    FZD5Q134673, ENSP000003546074I2D: score=1 STRING: ENSP00000354607
    FZD9O001443, ENSP000003457854I2D: score=1 STRING: ENSP00000345785
    DVL1O146403, ENSP000003681694I2D: score=1 STRING: ENSP00000368169
    PORCNQ9H2373, ENSP000003223044I2D: score=3 STRING: ENSP00000322304
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 51):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000578embryonic axis specification IMP16826533
    GO:0001502cartilage condensation IDA17202865
    GO:0002062chondrocyte differentiation IDA17202865
    GO:0007269neurotransmitter secretion IEA--
    GO:0007275multicellular organismal development ----

    WNT7A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WNT7A

    4 Novoseek inferred chemical compound relationships for WNT7A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diethylstilbestrol 43 2 16534752 (2)
    estrogen 16 3 11232041 (2), 12183078 (1)
    glycogen 12.2 1 12915680 (1)
    steroid 6.98 1 16534752 (1)



    WNT7A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for WNT7A gene: 
    NM_004625.3  

    Unigene Cluster for WNT7A:

    Wingless-type MMTV integration site family, member 7A
    Hs.72290  [show with all ESTs]
    Unigene Representative Sequence: NM_004625
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000285018(uc003bye.1) ENST00000489346 ENST00000497808
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      QuantiTect SYBR Green Assays in human, mouse, rat WNT7A
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    Additional mRNA sequence: 

    BC008811.2 D83175.1 U53476.1 

    2 DOTS entries:

    DT.453534  DT.443843 

    Selected AceView cDNA sequences (see all 27):

    NM_004625 BC008811 BE740508 AW161869 AA159189 AL548369 D83175 CB989433 
    AI885451 AI040985 BI551057 AL544633 AA657959 AW519058 AL570805 AA405326 
    AA412463 AI612812 AW340840 BI552826 AL572952 U53476 AA298813 AI887324 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for WNT7A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
    SP1:        -     -                     
    SP2:                                    


    ECgene alternative splicing isoforms for WNT7A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WNT7A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTGTGGGC
    WNT7A Expression
    About this image


    WNT7A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Apical Ectodermal Ridge Cells Limb Ectoderm
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Ectoderm (Gastrulation Derivatives)
             Apical Ectodermal Ridge Cells Limb Ectoderm
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle
             Midbrain tegmentum
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
    WNT7A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WNT7A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.72290

    UniProtKB/Swiss-Prot: WNT7A_HUMAN, O00755
    Tissue specificity: Expression is restricted to placenta, kidney, testis, uterus, fetal lung, and fetal and adult
    brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT7A: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT7A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WNT7A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wnt7a1 , 5 wingless-related MMTV integration site 7A1, 5 92.93(n)1
    99.43(a)1
      6 (40.45 cM)5
    224211  NM_009527.31  NP_033553.21 
     913639815 
    chicken
    (Gallus gallus)
    Aves WNT7A1 wingless-type MMTV integration site family, member more 80.71(n)
    93.98(a)
      374168  NM_204292.1  NP_989623.1 
    lizard
    (Anolis carolinensis)
    Reptilia WNT7A6
    wingless-type MMTV integration site family, member...
    94(a)
    1 ↔ 1
    GL343225.1(640781-702350)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia wnt7b1 wingless-type MMTV integration site family, member more 75.3(n)
    80.85(a)
      100145124  NM_001126633.1  NP_001120105.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570420982   -- 79.69(n)    57042098 
    fruit fly
    (Drosophila melanogaster)
    Insecta Wnt23 frizzled-2 receptor signaling pathway
    signal transducer
    49(a)   45E1   --


    ENSEMBL Gene Tree for WNT7A (if available)
    TreeFam Gene Tree for WNT7A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WNT7A gene
    WNT5B2  WNT162  WNT62  WNT5A2  WNT112  WNT22  WNT2B2  WNT3A2  
    WNT12  WNT42  WNT7B2  WNT32  
    18 SIMAP similar genes for WNT7A using alignment to 1 protein entry:     WNT7A_HUMAN:
    WNT7B    WNT2B    WNT4    WNT2    WNT3A    WNT5B
    WNT5A    WNT3    WNT16    WNT1    WNT8A    WNT11
    WNT10B    WNT6    WNT8B    WNT9B    WNT9A    WNT10A

    WNT7A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WNT7A (see all 1577)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0644804
    Limb pelvis hypoplasia aplasia syndrome (LPHAS)4--see VAR_0644802 R W mis40--------
    VAR_0657654
    Limb pelvis hypoplasia aplasia syndrome (LPHAS)4--see VAR_0657652 E K mis40--------
    VAR_0306744
    Limb pelvis hypoplasia aplasia syndrome (LPHAS)4--see VAR_0306742 R C mis40--------
    VAR_0306734
    Fuhrmann syndrome (FUHRS)4--see VAR_0306732 A T mis40--------
    rs1048938351,2
    Cpathogenic113796246(-) AGGGCC/TGCGCC 2 R C mis10--------
    rs1048938321,2
    Cpathogenic113831903(-) CCTACA/GCCATC 2 T A mis10--------
    rs1176558021,2
    F--13795211(+) AGGCCG/ATGGAA 1 -- int11Minor allele frequency- A:0.01EA 120
    rs1472434931,2
    C--13795318(+) AAACTG/TCTGGG 1 -- int10--------
    rs1452497441,2
    C--13795339(+) TTTTC-/CTCT  
            
    CTATT
    1 -- int10--------
    rs777713301,2
    C--13795341(+) TTCCTA/CTCTAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for WNT7A (13857755 - 13921618 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for WNT7A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2063559CNV Deletion18987734
    esv2724944CNV Deletion23290073
    nsv3709CNV Insertion18451855
    nsv876550CNV Loss21882294
    esv34163CNV Loss18971310
    nsv834618CNV Loss17160897

    Human Gene Mutation Database (HGMD): WNT7A
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing WNT7A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601570   
    OMIM disorders: 276820  228930  
    UniProtKB/Swiss-Prot: WNT7A_HUMAN, O00755
  • Limb pelvis hypoplasia aplasia syndrome (LPHAS) [MIM:276820]: A syndrome of severe deficiency of the
    extremities due to hypo- or aplasia of one or more long bones of one or more limbs. Pelvic manifestations include
    hip dislocation, hypoplastic iliac bone and aplastic pubic bones. Thoracic deformity, unusual facies and
    genitourinary anomalies can be present. Note=The disease is caused by mutations affecting the gene represented in
    this entry
  • Fuhrmann syndrome (FUHRS) [MIM:228930]: Distinct limb-malformation disorder characterized also by various
    degrees of limb aplasia/hypoplasia and joint dysplasia. Note=The disease is caused by mutations affecting the
    gene represented in this entry

  • Selected diseases for WNT7A (see all 34):    
    About MalaCards
    fuhrmann syndrome    ulna and fibula absence of with severe limb deficiency    fibular aplasia    skeletal muscle regeneration
    talipes equinovarus    mayer-rokitansky-kuster-hauser syndrome    nail-patella syndrome    fragile x syndrome
    clubfoot    endometrial adenocarcinoma    endometrial carcinoma    cleft palate
    cleft lip    leiomyoma    basal cell carcinoma    clear cell renal cell carcinoma
    labyrinthitis    esophageal squamous cell carcinoma    bipolar disorder    lung cancer

    1 disease from the University of Copenhagen DISEASES database for WNT7A:
    nail-patella syndrome

    WNT7A for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for WNT7A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    endometrial carcinoma 41.3 3 16534752 (2), 18567805 (1)
    cancer 0 2 15751030 (1)

    Genetic Association Database (GAD): WNT7A
    Human Genome Epidemiology (HuGE) Navigator: WNT7A (9 documents)

    Export disorders for WNT7A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WNT7A gene, integrated from 10 sources (see all 93):
    (articles sorted by number of sources associating them with WNT7A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a full-length human WNT7A gene implicated in limb development and cell transformation, and mapping to chromosome 3p25. (PubMed id 9161407)1, 2, 3, 9 Bui T.D....Harris A.L. (Gene 1997)
    2. Isolation, characterization and chromosomal assignment of the human WNT7A gene. (PubMed id 8893824)1, 2, 3 Ikegawa S....Nakamura Y. (Cytogenet. Cell Genet. 1996)
    3. Al-Awadi-Raas-Rothschild (limb/pelvis/uterus-hypoplasia/aplasia) syndrome and WNT7A mutations: genetic homogeneity and nosological delineation. (PubMed id 21271649)1, 2 Garavelli L....Superti-Furga A. (Am. J. Med. Genet. A 2011)
    4. A novel homozygous Arg222Trp missense mutation in WNT7A in two sisters with severe Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndrome. (PubMed id 20949531)1, 2 Kantaputra P.N.... Sripathomsawat W. (Am. J. Med. Genet. A 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Pathway-based approaches to imaging genetics association studies: Wnt signaling, GSK3beta substrates and major depression. (PubMed id 20219685)1, 4 Inkster B....Matthews P.M. (Neuroimage 2010)
    7. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    8. Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. (PubMed id 19054571)1, 4 GregA^rio S.P....Dias-Neto E. (Psychiatry Res 2009)
    9. Evaluation of CAND2 and WNT7a as candidate genes for congenital idiopathic clubfoot. (PubMed id 19159115)1, 4 Shyy W....Morcuende J.A. (Clin. Orthop. Relat. Res. 2009)
    10. Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate. (PubMed id 18413325)1, 4 Chiquet B.T....Hecht J.T. (Hum. Mol. Genet. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7476 HGNC: 12786 AceView: WNT7A Ensembl:ENSG00000154764 euGenes: HUgn7476
    ECgene: WNT7A Kegg: 7476 H-InvDB: WNT7A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WNT7A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT7A Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=WNT7A[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WNT7A gene:
    Search GeneIP for patents involving WNT7A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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