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Aliases for WNT7A Gene

Aliases for WNT7A Gene

  • Wingless-Type MMTV Integration Site Family, Member 7A 2 3
  • Proto-Oncogene Wnt7a Protein 2

External Ids for WNT7A Gene

Summaries for WNT7A Gene

Entrez Gene Summary for WNT7A Gene

  • This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT7A Gene

WNT7A (Wingless-Type MMTV Integration Site Family, Member 7A) is a Protein Coding gene. Diseases associated with WNT7A include ulna and fibula, absence of, with severe limb deficiency and fuhrmann syndrome. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include receptor binding and frizzled binding. An important paralog of this gene is WNT1.

UniProtKB/Swiss-Prot for WNT7A Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts (By similarity).

Gene Wiki entry for WNT7A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT7A Gene

Genomics for WNT7A Gene

Genomic Location for WNT7A Gene

Start:
13,816,258 bp from pter
End:
13,880,121 bp from pter
Size:
63,864 bases
Orientation:
Minus strand

Genomic View for WNT7A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WNT7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT7A Gene

Regulatory Elements for WNT7A Gene

Proteins for WNT7A Gene

  • Protein details for WNT7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00755-WNT7A_HUMAN
    Recommended name:
    Protein Wnt-7a
    Protein Accession:
    O00755
    Secondary Accessions:
    • Q96H90
    • Q9Y560

    Protein attributes for WNT7A Gene

    Size:
    349 amino acids
    Molecular mass:
    39005 Da
    Quaternary structure:
    • Interacts with PORCN.

    Three dimensional structures from OCA and Proteopedia for WNT7A Gene

neXtProt entry for WNT7A Gene

Proteomics data for WNT7A Gene at MOPED

Post-translational modifications for WNT7A Gene

  • Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn83, Asn127, and Asn295

Other Protein References for WNT7A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for WNT7A Gene

Domains for WNT7A Gene

Gene Families for WNT7A Gene

HGNC:
  • WNT :Wingless-type MMTV integration sites

Protein Domains for WNT7A Gene

Suggested Antigen Peptide Sequences for WNT7A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00755

UniProtKB/Swiss-Prot:

WNT7A_HUMAN
Family:
  • Belongs to the Wnt family.:
    • O00755
genes like me logo Genes that share domains with WNT7A: view

Function for WNT7A Gene

Molecular function for WNT7A Gene

GENATLAS Biochemistry: wingless-type MMTV integration site 7A,Drosophila wingless (Wg) segment polarity gene homolog,controlling limb development at the dorsoventral axis,modulating cell fate and cell behavior during vertebrate development, upregulating LMX1A expression in limbs mesenchyme and dorsal differentiation
UniProtKB/Swiss-Prot Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts (By similarity).

LifeMap Function Summary for WNT7A Gene

Gene Ontology (GO) - Molecular Function for WNT7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 12857724
GO:0005109 frizzled binding IBA --
GO:0005125 cytokine activity IDA 18986540
GO:0005515 protein binding --
GO:0048018 receptor agonist activity IDA 18986540
genes like me logo Genes that share ontologies with WNT7A: view
genes like me logo Genes that share phenotypes with WNT7A: view

Animal Models for WNT7A Gene

MGI Knock Outs for WNT7A:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for WNT7A Gene

Localization for WNT7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT7A Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WNT7A Gene COMPARTMENTS Subcellular localization image for WNT7A gene
Compartment Confidence
extracellular 5
mitochondrion 3
plasma membrane 3
cytosol 2
golgi apparatus 2
nucleus 1

Gene Ontology (GO) - Cellular Components for WNT7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IBA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005796 Golgi lumen TAS --
genes like me logo Genes that share ontologies with WNT7A: view

Pathways for WNT7A Gene

genes like me logo Genes that share pathways with WNT7A: view

Gene Ontology (GO) - Biological Process for WNT7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000578 embryonic axis specification IMP 16826533
GO:0001502 cartilage condensation IDA 17202865
GO:0001525 angiogenesis IEA --
GO:0002062 chondrocyte differentiation IDA 17202865
GO:0007269 neurotransmitter secretion IEA --
genes like me logo Genes that share ontologies with WNT7A: view

Compounds for WNT7A Gene

(4) Novoseek inferred chemical compound relationships for WNT7A Gene

Compound -log(P) Hits PubMed IDs
diethylstilbestrol 43 2
estrogen 16 3
glycogen 12.2 1
steroid 6.98 1
genes like me logo Genes that share compounds with WNT7A: view

Transcripts for WNT7A Gene

mRNA/cDNA for WNT7A Gene

Unigene Clusters for WNT7A Gene

Wingless-type MMTV integration site family, member 7A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WNT7A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1: - -
SP2:

Relevant External Links for WNT7A Gene

GeneLoc Exon Structure for
WNT7A
ECgene alternative splicing isoforms for
WNT7A

Expression for WNT7A Gene

mRNA expression in normal human tissues for WNT7A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT7A Gene

This gene is overexpressed in Brain - Cortex (5.7), Brain - Amygdala (5.2), Brain - Frontal Cortex (BA9) (4.9), Brain - Nucleus accumbens (basal ganglia) (4.3), Brain - Anterior cingulate cortex (BA24) (4.1), and Brain - Putamen (basal ganglia) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for WNT7A Gene

SOURCE GeneReport for Unigene cluster for WNT7A Gene Hs.72290

mRNA Expression by UniProt/SwissProt for WNT7A Gene

O00755-WNT7A_HUMAN
Tissue specificity: Expression is restricted to placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain
genes like me logo Genes that share expressions with WNT7A: view

Orthologs for WNT7A Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT7A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WNT7A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WNT7A 35
  • 94.17 (n)
  • 98.57 (a)
WNT7A 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WNT7A 35
  • 95.22 (n)
  • 99.71 (a)
WNT7A 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wnt7a 35
  • 92.93 (n)
  • 99.43 (a)
Wnt7a 16
Wnt7a 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WNT7A 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WNT7A 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wnt7a 35
  • 91.21 (n)
  • 99.14 (a)
chicken
(Gallus gallus)
Aves WNT7A 35
  • 80.71 (n)
  • 93.98 (a)
WNT7A 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WNT7A 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wnt7b 35
  • 75.3 (n)
  • 80.85 (a)
zebrafish
(Danio rerio)
Actinopterygii WNT7A (1 of 2) 36
  • 81 (a)
OneToMany
wnt7aa 35
  • 75.93 (n)
  • 86.25 (a)
wnt7aa 36
  • 86 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Wnt2 36
  • 47 (a)
OneToMany
Wnt2 37
  • 49 (a)
worm
(Caenorhabditis elegans)
Secernentea lin-44 37
  • 31 (a)
egl-20 37
  • 38 (a)
mom-2 37
  • 35 (a)
cwn-2 37
  • 42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for WNT7A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT7A Gene

ENSEMBL:
Gene Tree for WNT7A (if available)
TreeFam:
Gene Tree for WNT7A (if available)

Paralogs for WNT7A Gene

Paralogs for WNT7A Gene

Selected SIMAP similar genes for WNT7A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WNT7A: view

Variants for WNT7A Gene

Sequence variations from dbSNP and Humsavar for WNT7A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs734176 -- 13,831,954(+) ACAAC(A/G)TGGAG intron-variant
rs867606 -- 13,827,804(+) CTGCT(C/T)GCTGT intron-variant
rs873853 -- 13,822,841(-) CACCA(C/T)GGTAG intron-variant
rs934450 -- 13,846,232(-) TCCTC(A/G)GCCCC intron-variant
rs934453 -- 13,828,555(+) ACAGA(C/T)AGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WNT7A Gene

Variant ID Type Subtype PubMed ID
nsv876550 CNV Loss 21882294
nsv834618 CNV Loss 17160897
nsv3709 CNV Insertion 18451855
esv34163 CNV Loss 18971310
esv2063559 CNV Deletion 18987734
esv2724944 CNV Deletion 23290073

Relevant External Links for WNT7A Gene

HapMap Linkage Disequilibrium report
WNT7A
Human Gene Mutation Database (HGMD)
WNT7A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT7A Gene

Disorders for WNT7A Gene

(2) OMIM Diseases for WNT7A Gene (601570)

UniProtKB/Swiss-Prot

WNT7A_HUMAN
  • Limb pelvis hypoplasia aplasia syndrome (LPHAS) [MIM:276820]: A syndrome of severe deficiency of the extremities due to hypo- or aplasia of one or more long bones of one or more limbs. Pelvic manifestations include hip dislocation, hypoplastic iliac bone and aplastic pubic bones. Thoracic deformity, unusual facies and genitourinary anomalies can be present. {ECO:0000269 PubMed:16826533, ECO:0000269 PubMed:17431918, ECO:0000269 PubMed:20949531, ECO:0000269 PubMed:21271649}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Fuhrmann syndrome (FUHRS) [MIM:228930]: Distinct limb-malformation disorder characterized also by various degrees of limb aplasia/hypoplasia and joint dysplasia. {ECO:0000269 PubMed:16826533}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for WNT7A Gene

(2) Novoseek inferred disease relationships for WNT7A Gene

Disease -log(P) Hits PubMed IDs
endometrial carcinoma 41.3 3
cancer 0 1

Relevant External Links for WNT7A

Genetic Association Database (GAD)
WNT7A
Human Genome Epidemiology (HuGE) Navigator
WNT7A
genes like me logo Genes that share disorders with WNT7A: view

Publications for WNT7A Gene

  1. Isolation of a full-length human WNT7A gene implicated in limb development and cell transformation, and mapping to chromosome 3p25. (PMID: 9161407) Bui T.D. … Harris A.L. (Gene 1997) 2 3 4 23
  2. Isolation, characterization and chromosomal assignment of the human WNT7A gene. (PMID: 8893824) Ikegawa S. … Nakamura Y. (Cytogenet. Cell Genet. 1996) 2 3 4
  3. Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation. (PMID: 18986540) Davis E.K. … Ghosh A. (Neural Dev 2008) 3 23
  4. Mutations in WNT7A cause a range of limb malformations, including Fuhrmann syndrome and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndrome. (PMID: 16826533) Woods C.G. … Mundlos S. (Am. J. Hum. Genet. 2006) 3 4
  5. A novel homozygous Arg222Trp missense mutation in WNT7A in two sisters with severe Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndrome. (PMID: 20949531) Kantaputra P.N. … Sripathomsawat W. (Am. J. Med. Genet. A 2010) 3 4

Products for WNT7A Gene

  • Addgene plasmids for WNT7A

Sources for WNT7A Gene

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