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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

WNT7A Gene

protein-coding GIFtS: 66
GCID: GC03M013835

wingless-type MMTV integration site family, member 7A

Explore 33 diseases affiliated with
WNT7A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Wingless-Type MMTV Integration Site Family, Member 7A¹ ²
Protein Wnt-7a²
Proto-Oncogene Wnt7a Protein²

External Ids:	HGNC: 12786¹	Entrez Gene: 7476²	Ensembl: ENSG00000154764⁷	OMIM: 601570⁵	UniProtKB: O00755³

Export aliases for WNT7A gene to outside databases

Previous GC identifers: GC03M013789 GC03M013851

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WNT7A:

This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted

signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes,

including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the

anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle

pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and

Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: WNT7A_HUMAN, O00755

Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein.

Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts (By similarity)

Gene Wiki entry for WNT7A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the WNT7A gene promoter:
N-Myc PPAR-gamma1 Pax-5 PPAR-gamma2 E47 HNF-4alpha1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WNT7A promoter sequence

Search SABiosciences Chromatin IP Primers for WNT7A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WNT7A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25 Ensembl cytogenetic band: 3p25.1 HGNC cytogenetic band: 3p25

WNT7A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT7A gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M013835: view genomic region (about GC identifiers)

Start:	13,857,755 bp from pter	End:	13,921,618 bp from pter
Size:	63,864 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: WNT7A_HUMAN, O00755 (See protein sequence)

Recommended Name: Protein Wnt-7a precursor

Size: 349 amino acids; 39005 Da

Subunit: Interacts with PORCN (By similarity)

Subcellular location: Secreted, extracellular space, extracellular matrix

Secondary accessions: Q96H90 Q9Y560

Explore the universe of human proteins at neXtProt for WNT7A: NX_O00755

Post-translational modifications:

Palmitoylation at Ser-206 is required for efficient binding to frizzled receptors. It is also required for subsequent

palmitoylation at Cys-73. Palmitoylation is necessary for proper trafficking to cell surface (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O00755

WNT7A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004616.2

ENSEMBL proteins:

ENSP00000285018

Reactome Protein details: O00755
Human Recombinant Protein Products for WNT7A:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for WNT7A

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005615	extracellular space	IBA	--
GO:0005886	plasma membrane	IBA	--
GO:0009986	cell surface	IEA	--
GO:0031012	extracellular matrix	--	--

WNT7A for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for WNT7A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

WNT7A for domains About GeneDecksing

3 InterPro domains/families:

IPR013300 Wnt7

IPR005817 Wnt

IPR018161 Wnt_CS

Graphical View of Domain Structure for InterPro Entry O00755

ProtoNet protein and cluster: O00755

1 Blocks protein family: IPB005816 Secreted growth factor Wnt protein

UniProtKB/Swiss-Prot: WNT7A_HUMAN, O00755

Similarity: Belongs to the Wnt family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: WNT7A_HUMAN, O00755

Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein.

Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts (By similarity)

Genatlas biochemistry entry for WNT7A:

wingless-type MMTV integration site 7A,Drosophila wingless (Wg) segment polarity gene homolog,controlling limb

development at the dorsoventral axis,modulating cell fate and cell behavior during vertebrate development,

upregulating LMX1A expression in limbs mesenchyme and dorsal differentiation

Summary:

During embryonic development, WNT7A as signaling molecule is secreted from the following cells: Apical Ectodermal Ridge Cells in Limb Ectoderm, Surface Ectoderm Cells in Surface Ectoderm

It affects the following cells: Prechondrocytic Mesenchymal Cells in Autopod, Prechondrocytic Mesenchymal Cells in Zeugopod (see all 4).

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	IPI	12857724
GO:0005109	frizzled binding	IBA	--
GO:0005125	cytokine activity	IDA	18986540
GO:0048018	receptor agonist activity	IDA	18986540

WNT7A for ontologies About GeneDecksing

Phenotypes:
12 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Wnt7a):

behavior/neurological	cardiovascular system	embryogenesis	hearing/vestibular/ear	integument
limbs/digits/tail	mortality/aging	nervous system	normal	reproductive system
skeleton	vision/eye

WNT7A for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Wnt7a^tm1Amc for WNT7A

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for WNT7A

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		hsa-miR-361-5p hsa-miR-137 hsa-miR-922 hsa-miR-15a hsa-miR-497 hsa-miR-3190 hsa-miR-520a-5p hsa-miR-374a*

		SwitchGear 3'UTR luciferase reporter plasmid: WNT7A 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT7A

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Wnt Signaling Pathway

Wnt Signaling Pathway	1.00	Wnt Signaling Pathway	0.33
Wnt Signaling Pathway and Pluripotency	0.55	Wnt signaling pathway	0.30
DNA damage response (only ATM dependent)	0.35	Wnt Signaling Pathway NetPath	0.22

Basal cell carcinoma

	Basal cell carcinoma	1.00			Wnt Pathway	0.37
	Hedgehog signaling pathway	0.41			Melanogenesis	0.32

Translation_Non-genomic (rapid) action of Androgen Receptor

Translation_Non-genomic (rapid) action of Androgen Receptor

1.00

Translation Non-genomic (rapid) action of Androgen Receptor

0.99

Transcription_Androgen Receptor nuclear signaling

Transcription_Androgen Receptor nuclear signaling

1.00

Transcription Androgen Receptor nuclear signaling

0.99

Nanog in Mammalian ESC Pluripotency

Nanog in Mammalian ESC Pluripotency

1.00

GSK3 Signaling

0.61

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for WNT7A

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

1 R&D Systems Pathway for WNT7A

Wnt Signaling Pathway

5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for WNT7A (see all 7)

	GSK3 Signaling
	Presenilin-Mediated Signaling
	Colorectal Cancer Metastasis
	Human Embryonic Stem Cell Pluripotency
	Nanog in Mammalian ESC Pluripotency

1 Tocris Bioscience Pathway for WNT7A

Wnt Pathway

2 GeneGo (Thomson Reuters) Pathways for WNT7A

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

5 BioSystems Pathways for WNT7A

	Wnt Signaling Pathway
	Wnt Signaling Pathway and Pluripotency
	DNA damage response (only ATM dependent)
	Wnt Signaling Pathway NetPath
	Wnt signaling network

4 Reactome Pathways for WNT7A

	Signal Transduction
	Signaling by GPCR
	GPCR ligand binding
	Class B/2 (Secretin family receptors)

5 Kegg Pathways (Kegg details for WNT7A):

	Wnt signaling pathway
	Hedgehog signaling pathway
	Melanogenesis
	Pathways in cancer
	Basal cell carcinoma

WNT7A for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for WNT7A

STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

5/20 Interacting proteins for WNT7A (O00755^{2, 3} ENSP00000285018⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
STRN4	Q9NRL3²^,³	MINT-65611 I2D: score=4
FZD5	Q13467³, ENSP00000354607⁴	I2D: score=1 STRING: ENSP00000354607
FZD9	O00144³, ENSP00000345785⁴	I2D: score=1 STRING: ENSP00000345785
PORCN	Q9H237³, ENSP00000322304⁴	I2D: score=3 STRING: ENSP00000322304
WIF1	Q9Y5W5², ENSP00000286574⁴	MINT-8389828 STRING: ENSP00000286574

About this table

Gene Ontology (GO): 5/46 biological process terms (GO ID links to tree view) (see all 46): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000578	embryonic axis specification	IMP	16826533
GO:0001501	skeletal system development	IBA	--
GO:0007165	signal transduction	--	--
GO:0007257	activation of JUN kinase activity	IBA	--
GO:0007269	neurotransmitter secretion	IEA	--

WNT7A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

WNT7A for compounds About GeneDecksing

EMD Millipore small molecules for WNT7A:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for WNT7A
4 Novoseek chemical compound relationships for WNT7A gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
diethylstilbestrol	43	2	16534752 (2)
estrogen	16	3	11232041 (2), 12183078 (1)
glycogen	12.2	1	12915680 (1)
steroid	6.98	1	16534752 (1)

Search CenterWatch for drugs/clinical trials and news about WNT7A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for WNT7A gene:

NM_004625.3

Unigene Cluster for WNT7A:

Wingless-type MMTV integration site family, member 7A

Hs.72290 [show with all ESTs]

Unigene Representative Sequence: NM_004625

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000285018(uc003bye.1) ENST00000489346 ENST00000497808

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		hsa-miR-361-5p hsa-miR-137 hsa-miR-922 hsa-miR-15a hsa-miR-497 hsa-miR-3190 hsa-miR-520a-5p hsa-miR-374a*

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Additional cDNA sequence:

BC008811.2 D83175.1 U53476.1

2 DOTS entries:

DT.453534 DT.443843

24/27 AceView cDNA sequences (see all 27):

BC008811 NM_004625 AL548369 AA159189 AW161869 D83175 CB989433 BE740508

AL544633 BI551057 AA657959 AI040985 AI885451 AW340840 BI552826 AL572952

AL570805 AW519058 U53476 AA405326 AI612812 AA412463 AA298813 AA412464

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for WNT7A About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6
SP1:			-		-
SP2:

ECgene alternative splicing isoforms for WNT7A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

WNT7A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCTGTGGGC

About this image

WNT7A expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/14 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 14)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Limb Ectoderm

Apical Ectodermal Ridge Cells

Selective marker (cell-identifying gene)

Dermis, Ectoderm

Limb

Autopod

Mesenchymal Condensate Cells

Bone, Cartilage

Limb

Stylopod

Mesenchymal Condensate Cells

Bone, Cartilage

Limb

Zeugopod

Mesenchymal Condensate Cells

Bone, Cartilage

Primitive Streak

Primitive Streak Cells

Early Embryo

Reproductive System

Testis

Bone

Brain

Brain

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Endothelial cells and neural cells (Derivation of blood-...)

See WNT7A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WNT7A

SOURCE GeneReport for Unigene cluster: Hs.72290

UniProtKB/Swiss-Prot: WNT7A_HUMAN, O00755

Tissue specificity: Expression is restricted to placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain

SABiosciences Expression via Pathway-Focused PCR Arrays including WNT7A:

Hedgehog Signaling Pathway in human mouse rat

WNT Signaling Pathway in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT7A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for WNT7A gene from 4/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	WNT7A¹	wingless-type MMTV integration site family, member more	80.71(n) 93.98(a)		374168 NM_204292.1 NP_989623.1
lizard (Anolis carolinensis)	Reptilia	WNT7A⁶	--	94(a)	1 ↔ 1	GL343225.1(640781-701793)
zebrafish (Danio rerio)	Actinopterygii	57042098²	--	79.69(n)		57042098
fruit fly (Drosophila melanogaster)	Insecta	Wnt2³	frizzled-2 receptor signaling pathway signal transducer	49(a)		45E1 --

ENSEMBL Gene Tree for WNT7A (if available)
TreeFam Gene Tree for WNT7A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for WNT7A gene

WNT5B² WNT16² WNT6² WNT5A² WNT11² WNT2² WNT2B² WNT3A²

WNT1² WNT10B² WNT4² WNT7B² WNT10A² WNT3²

18 SIMAP similar genes for WNT7A using alignment to 1 protein entry: WNT7A_HUMAN:

WNT7B WNT2B WNT4 WNT2 WNT3A WNT5B

WNT5A WNT3 WNT16 WNT1 WNT8A WNT11

WNT10B WNT6 WNT8B WNT9B WNT9A WNT10A

WNT7A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs104893835^1,2	C	pathogenic	13860617(-)	`AGGGCC/TGCGCC`	2	R C	mis¹		0	--	--	--	--
rs104893832^1,2	C	pathogenic	13896274(-)	`CCTACA/GCCATC`	2	T A	mis¹		0	--	--	--	--
rs117655802^1,2		--	13859582(+)	`AGGCCG/ATGGAA`	1	--	int¹		1		EA	120
rs147243493^1,2		--	13859689(+)	`AAACTG/TCTGGG`	1	--	int¹		0	--	--	--	--
rs145249744^1,2	C	--	13859710(+)	`TTTTC-/CTCT CTATT`	1	--	int¹		0	--	--	--	--
rs77771330^1,2	C	--	13859712(+)	`TTCCTA/CTCTAT`	1	--	int¹		0	--	--	--	--
rs192258819^1,2		--	13859746(+)	`ATGGTG/TAAGTT`	1	--	int¹		0	--	--	--	--
rs140867642^1,2		--	13859749(+)	`GTGAAA/GTTTGA`	1	--	int¹		0	--	--	--	--
rs144670803^1,2		--	13859782(+)	`AAAACA/GTACTC`	1	--	int¹		0	--	--	--	--
rs184572865^1,2		--	13859798(+)	`AAAACA/GTCTCC`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for WNT7A (13857755 - 13921618 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for WNT7A
1 CNV: 48019
1 Indel: 46296
Human Gene Mutation Database (HGMD): WNT7A

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

WNT7A for disorders           About GeneDecksing

OMIM gene information: 601570
OMIM disorders: 276820  228930
UniProtKB/Swiss-Prot: WNT7A_HUMAN, O00755

Defects in WNT7A are the cause of limb pelvis hypoplasia aplasia syndrome (LPHAS) [MIM:276820]. A syndrome of

severe deficiency of the extremities due to hypo- or aplasia of one or more long bones of one or more limbs. Pelvic

manifestations include hip dislocation, hypoplastic iliac bone and aplastic pubic bones. Thoracic deformity, unusual

facies and genitourinary anomalies can be present

Defects in WNT7A are a cause of Fuhrmann syndrome (FUHRS) [MIM:228930]; also known as fibular aplasia or

hypoplasia femoral bowing and poly- syn- and oligodactyly. Fuhrmann syndrome is a distinct limb-malformation disorder

characterized also by various degrees of limb aplasia/hypoplasia and joint dysplasia

20/33 diseases for WNT7A (see all 33): About MalaCards

mayer-rokitansky-kuster-hauser syndrome rokitansky-kuster-hauser syndrome ulna and fibula, absence of, with sever limb deficiency ulna and fibula absence of with severe limb deficiency

tetra-amelia fibular aplasia nail-patella syndrome skeletal muscle regeneration

talipes equinovarus fuhrmann syndrome fragile x syndrome arterial calcification

cleft lip esophageal squamous cell carcinoma squamous cell carcinoma cleft palate

basal cell carcinoma endometrial carcinoma clubfoot bipolar disorder

2 Novoseek disease relationships for WNT7A gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
endometrial carcinoma	41.3	3	16534752 (2), 18567805 (1)
cancer	0	2	15751030 (1)

Human Genome Epidemiology (HuGE) Navigator: WNT7A (9 documents)

Export disorders for WNT7A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for WNT7A gene, integrated from 9 sources (see all 87):
(articles sorted by number of sources associating them with WNT7A)

Utopia: connect your pdf to the dynamic
world of online information

Isolation of a full-length human WNT7A gene implicated in limb development and cell transformation, and mapping to chromosome 3p25. (PubMed id 9161407)^{1, 2, 3, 9} Bui T.D....Harris A.L. (1997)
Isolation, characterization and chromosomal assignment of the human WNT7A gene. (PubMed id 8893824)^{1, 2, 3} Ikegawa S....Nakamura Y. (1996)
Al-Awadi-Raas-Rothschild (limb/pelvis/uterus-hypoplas ia/aplasia) syndrome and WNT7A mutations: genetic homogeneity and nosological d elineation. (PubMed id 21271649)^{1, 2} Garavelli L....Superti-Furga A. (2011)
A novel homozygous Arg222Trp missense mutation in WNT7A in two sisters with severe Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndrome. (PubMed id 20949531)^{1, 2} Kantaputra P.N.... Sripathomsawat W. (2010)
Mutations in WNT7A cause a range of limb malformations, including Fuhrmann syndrome and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndrome. (PubMed id 16826533)^{1, 2} Woods C.G.... Mundlos S. (2006)
Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. (PubMed id 8168088)^{1, 2} Huguet E.L.... Harris A.L. (1994)
Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation. (PubMed id 15705594)^{1, 9} Winn R.A....Heasley L.E. (2005)
Decreased expression of Wnt7a mRNA is inversely associated with the expression of estrogen receptor-alpha in human uterine leiomyoma. (PubMed id 11232041)^{1, 9} Li S....McLachlan J.A. (2001)
Wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing. (PubMed id 15802269)^{1, 9} Lyu J. and Joo C.K. (2005)
Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation. (PubMed id 18986540)^{1, 9} Davis E.K....Ghosh A. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7476	HGNC: 12786	AceView: WNT7A	Ensembl:ENSG00000154764	euGenes: HUgn7476
ECgene: WNT7A	Kegg: 7476	H-InvDB: WNT7A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for WNT7A	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for WNT7A	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/WNT7A

Intellectual Property for WNT7A gene
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Patent Information for WNT7A gene:
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GeneCards and IP:
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wingless-type MMTV integration site family, member 7A

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WNT7A Gene

wingless-type MMTV integration site family, member 7A

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