Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WNT7A Gene

Aliases for WNT7A Gene

  • Wnt Family Member 7A 2 3
  • Wingless-Type MMTV Integration Site Family, Member 7A 2
  • Wingless-Type MMTV Integration Site Family Member 7A 5
  • Proto-Oncogene Wnt7a Protein 2

External Ids for WNT7A Gene

Previous GeneCards Identifiers for WNT7A Gene

  • GC03M013789
  • GC03M013851
  • GC03M013835
  • GC03M013817

Summaries for WNT7A Gene

Entrez Gene Summary for WNT7A Gene

  • This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT7A Gene

WNT7A (Wnt Family Member 7A) is a Protein Coding gene. Diseases associated with WNT7A include fuhrmann syndrome and ulna and fibula, absence of, with severe limb deficiency. Among its related pathways are Signaling by GPCR and Wnt Signaling Pathway (WikiPathways). GO annotations related to this gene include receptor binding and frizzled binding. An important paralog of this gene is WNT5B.

UniProtKB/Swiss-Prot for WNT7A Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts (By similarity).

Gene Wiki entry for WNT7A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT7A Gene

Genomics for WNT7A Gene

Regulatory Elements for WNT7A Gene

Promoters for WNT7A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WNT7A on UCSC Golden Path with GeneCards custom track

Genomic Location for WNT7A Gene

Chromosome:
3
Start:
13,816,258 bp from pter
End:
13,880,121 bp from pter
Size:
63,864 bases
Orientation:
Minus strand

Genomic View for WNT7A Gene

Genes around WNT7A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNT7A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNT7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT7A Gene

Proteins for WNT7A Gene

  • Protein details for WNT7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00755-WNT7A_HUMAN
    Recommended name:
    Protein Wnt-7a
    Protein Accession:
    O00755
    Secondary Accessions:
    • Q96H90
    • Q9Y560

    Protein attributes for WNT7A Gene

    Size:
    349 amino acids
    Molecular mass:
    39005 Da
    Quaternary structure:
    • Interacts with PORCN.

    Three dimensional structures from OCA and Proteopedia for WNT7A Gene

neXtProt entry for WNT7A Gene

Proteomics data for WNT7A Gene at MOPED

Post-translational modifications for WNT7A Gene

  • Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at Asn 83, Asn 127, and Asn 295
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT7A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for WNT7A Gene

Domains & Families for WNT7A Gene

Gene Families for WNT7A Gene

Protein Domains for WNT7A Gene

Suggested Antigen Peptide Sequences for WNT7A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00755

UniProtKB/Swiss-Prot:

WNT7A_HUMAN :
  • Belongs to the Wnt family.
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT7A: view

Function for WNT7A Gene

Molecular function for WNT7A Gene

GENATLAS Biochemistry:
wingless-type MMTV integration site 7A,Drosophila wingless (Wg) segment polarity gene homolog,controlling limb development at the dorsoventral axis,modulating cell fate and cell behavior during vertebrate development, upregulating LMX1A expression in limbs mesenchyme and dorsal differentiation
UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts (By similarity).

LifeMap Function Summary for WNT7A Gene

genes like me logo Genes that share phenotypes with WNT7A: view

Human Phenotype Ontology for WNT7A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for WNT7A Gene

MGI Knock Outs for WNT7A:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for WNT7A Gene

Localization for WNT7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT7A Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WNT7A Gene COMPARTMENTS Subcellular localization image for WNT7A gene
Compartment Confidence
extracellular 5
golgi apparatus 5
endoplasmic reticulum 4
mitochondrion 4
plasma membrane 4
cytosol 2
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for WNT7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0030666 endocytic vesicle membrane TAS --
genes like me logo Genes that share ontologies with WNT7A: view

Pathways & Interactions for WNT7A Gene

genes like me logo Genes that share pathways with WNT7A: view

SIGNOR curated interactions for WNT7A Gene

Activates:

Gene Ontology (GO) - Biological Process for WNT7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000578 embryonic axis specification IMP 16826533
GO:0001502 cartilage condensation IDA 17202865
GO:0001525 angiogenesis IEA --
GO:0002062 chondrocyte differentiation IDA 17202865
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with WNT7A: view

Drugs & Compounds for WNT7A Gene

(2) Drugs for WNT7A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for WNT7A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with WNT7A: view

Transcripts for WNT7A Gene

mRNA/cDNA for WNT7A Gene

Unigene Clusters for WNT7A Gene

Wingless-type MMTV integration site family, member 7A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WNT7A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1: - -
SP2:

Relevant External Links for WNT7A Gene

GeneLoc Exon Structure for
WNT7A
ECgene alternative splicing isoforms for
WNT7A

Expression for WNT7A Gene

mRNA expression in normal human tissues for WNT7A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT7A Gene

This gene is overexpressed in Brain - Cortex (x5.7), Brain - Amygdala (x5.2), Brain - Frontal Cortex (BA9) (x4.9), Brain - Nucleus accumbens (basal ganglia) (x4.3), Brain - Anterior cingulate cortex (BA24) (x4.1), and Brain - Putamen (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for WNT7A Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WNT7A Gene



SOURCE GeneReport for Unigene cluster for WNT7A Gene Hs.72290

mRNA Expression by UniProt/SwissProt for WNT7A Gene

O00755-WNT7A_HUMAN
Tissue specificity: Expression is restricted to placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain.
genes like me logo Genes that share expression patterns with WNT7A: view

Protein tissue co-expression partners for WNT7A Gene

Primer Products

In Situ Assay Products

Orthologs for WNT7A Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT7A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WNT7A 35
  • 94.17 (n)
  • 98.57 (a)
WNT7A 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WNT7A 35
  • 95.22 (n)
  • 99.71 (a)
WNT7A 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wnt7a 35
  • 92.93 (n)
  • 99.43 (a)
Wnt7a 16
Wnt7a 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wnt7a 35
  • 91.21 (n)
  • 99.14 (a)
oppossum
(Monodelphis domestica)
Mammalia WNT7A 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WNT7A 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WNT7A 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves WNT7A 35
  • 80.71 (n)
  • 93.98 (a)
WNT7A 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WNT7A 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wnt7b 35
  • 75.3 (n)
  • 80.85 (a)
zebrafish
(Danio rerio)
Actinopterygii wnt7aa 35
  • 75.93 (n)
  • 86.25 (a)
WNT7A (1 of 2) 36
  • 81 (a)
OneToMany
wnt7aa 36
  • 86 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Wnt2 37
  • 49 (a)
Wnt2 36
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cwn-2 37
  • 42 (a)
egl-20 37
  • 38 (a)
lin-44 37
  • 31 (a)
mom-2 37
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for WNT7A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT7A Gene

ENSEMBL:
Gene Tree for WNT7A (if available)
TreeFam:
Gene Tree for WNT7A (if available)

Paralogs for WNT7A Gene

Paralogs for WNT7A Gene

(18) SIMAP similar genes for WNT7A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WNT7A: view

Variants for WNT7A Gene

Sequence variations from dbSNP and Humsavar for WNT7A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_030673 Fuhrmann syndrome (FUHRS)
VAR_030674 Limb pelvis hypoplasia aplasia syndrome (LPHAS)
VAR_064480 Limb pelvis hypoplasia aplasia syndrome (LPHAS)
VAR_065765 Limb pelvis hypoplasia aplasia syndrome (LPHAS)
rs867606 -- 13,827,804(+) CTGCT(C/T)GCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WNT7A Gene

Variant ID Type Subtype PubMed ID
nsv876550 CNV Loss 21882294
nsv834618 CNV Loss 17160897
nsv3709 CNV Insertion 18451855
esv34163 CNV Loss 18971310
esv2063559 CNV Deletion 18987734
esv2724944 CNV Deletion 23290073

Variation tolerance for WNT7A Gene

Residual Variation Intolerance Score: 12.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WNT7A Gene

HapMap Linkage Disequilibrium report
WNT7A
Human Gene Mutation Database (HGMD)
WNT7A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT7A Gene

Disorders for WNT7A Gene

MalaCards: The human disease database

(9) MalaCards diseases for WNT7A Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
fuhrmann syndrome
  • fibular aplasia
ulna and fibula, absence of, with severe limb deficiency
  • ulna and fibula, absence of, with sever limb deficiency
phocomelia
myofibroma
  • lipoleiomyoma
skeletal muscle regeneration
  • nonaka myopathy
- elite association - COSMIC cancer census association via MalaCards
Search WNT7A in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

WNT7A_HUMAN
  • Fuhrmann syndrome (FUHRS) [MIM:228930]: Distinct limb-malformation disorder characterized also by various degrees of limb aplasia/hypoplasia and joint dysplasia. {ECO:0000269 PubMed:16826533}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Limb pelvis hypoplasia aplasia syndrome (LPHAS) [MIM:276820]: A syndrome of severe deficiency of the extremities due to hypo- or aplasia of one or more long bones of one or more limbs. Pelvic manifestations include hip dislocation, hypoplastic iliac bone and aplastic pubic bones. Thoracic deformity, unusual facies and genitourinary anomalies can be present. {ECO:0000269 PubMed:16826533, ECO:0000269 PubMed:17431918, ECO:0000269 PubMed:20949531, ECO:0000269 PubMed:21271649}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for WNT7A

Genetic Association Database (GAD)
WNT7A
Human Genome Epidemiology (HuGE) Navigator
WNT7A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WNT7A
genes like me logo Genes that share disorders with WNT7A: view

No data available for Genatlas for WNT7A Gene

Publications for WNT7A Gene

  1. Isolation of a full-length human WNT7A gene implicated in limb development and cell transformation, and mapping to chromosome 3p25. (PMID: 9161407) Bui T.D. … Harris A.L. (Gene 1997) 2 3 4 23 67
  2. Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation. (PMID: 18986540) Davis E.K. … Ghosh A. (Neural Dev 2008) 3 23
  3. Expression patterns of Wnt genes during development of an anterior part of the chicken eye. (PMID: 16258938) Fokina V.M. … Frolova E.I. (Dev. Dyn. 2006) 3 23
  4. BMP-2-enhanced chondrogenesis involves p38 MAPK-mediated down-regulation of Wnt-7a pathway. (PMID: 17202865) Jin E.J. … Kang S.S. (Mol. Cells 2006) 3 23
  5. Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation. (PMID: 15705594) Winn R.A. … Heasley L.E. (J. Biol. Chem. 2005) 3 23

Products for WNT7A Gene

Sources for WNT7A Gene

Back to Top

Content