Aliases for WNT7A Gene
External Ids for WNT7A Gene
Previous GeneCards Identifiers for WNT7A Gene
This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. [provided by RefSeq, Jul 2008]
GeneCards Summary for WNT7A Gene
WNT7A (Wnt Family Member 7A) is a Protein Coding gene. Diseases associated with WNT7A include Fuhrmann Syndrome and Ulna And Fibula, Absence Of, With Severe Limb Deficiency. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-independent Wnt/Ca2+ Signaling and Other Non-canonical Wnt Signaling Pathways and Transcription Androgen Receptor nuclear signaling. GO annotations related to this gene include receptor binding and frizzled binding. An important paralog of this gene is WNT7B.
UniProtKB/Swiss-Prot for WNT7A Gene
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts (By similarity).