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Aliases for WNT7A Gene

Aliases for WNT7A Gene

  • Wnt Family Member 7A 2 3 5
  • Wingless-Type MMTV Integration Site Family, Member 7A 2
  • Proto-Oncogene Wnt7a Protein 2

External Ids for WNT7A Gene

Previous GeneCards Identifiers for WNT7A Gene

  • GC03M013789
  • GC03M013851
  • GC03M013835
  • GC03M013817
  • GC03M013821
  • GC03M013918
  • GC03M014002
  • GC03M014123

Summaries for WNT7A Gene

Entrez Gene Summary for WNT7A Gene

  • This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT7A Gene

WNT7A (Wnt Family Member 7A) is a Protein Coding gene. Diseases associated with WNT7A include Fuhrmann Syndrome and Ulna And Fibula, Absence Of, With Severe Limb Deficiency. Among its related pathways are Transcription Androgen Receptor nuclear signaling and Endometrial cancer. GO annotations related to this gene include receptor binding and frizzled binding. An important paralog of this gene is WNT7B.

UniProtKB/Swiss-Prot for WNT7A Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts (By similarity).

Gene Wiki entry for WNT7A Gene

Additional gene information for WNT7A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT7A Gene

Genomics for WNT7A Gene

Regulatory Elements for WNT7A Gene

Enhancers for WNT7A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H013878 1.5 FANTOM5 Ensembl ENCODE 13 +0.5 504 3.2 ZNF76 KLF17 ZNF2 RAD21 ZEB1 GLIS2 ZNF391 CREM EGR2 SP3 HDAC11-AS1 ENSG00000223398 ENSG00000230172 WNT7A C3orf20 VN1R20P GC03M014350
GH03H013849 0.8 ENCODE 17.4 +27.5 27454 6.3 BCOR KLF1 JUN KLF17 ZMYM3 GLI4 ZIC2 CTBP1 ZNF366 ADNP WNT7A XPC GC03M014350
GH03H013824 0.5 ENCODE 20.5 +54.0 54018 3.6 ZNF316 GATA3 GLIS1 MNT MAFK WNT7A LINC00620 GC03M014350 GC03M014347
GH03H014369 1.9 FANTOM5 Ensembl ENCODE dbSUPER 4.6 -492.6 -492565 6.4 HNRNPUL1 HDGF PKNOX1 FOXA2 SIN3A ZNF2 SP3 ZNF592 SREBF1 SMARCA4 CCDC174 XPC TMEM43 ENSG00000228242 NR2C2 SH3BP5-AS1 SLC6A6 CAPN7 LINC01267 WNT7A
GH03H013587 0.7 dbSUPER 9.6 +291.3 291305 3 TAL1 BHLHE40 ZIC2 ATF2 TCF12 CREB1 PRDM10 ATF7 CREM SPI1 HDAC11 HDAC11-AS1 WNT7A GC03P013574 GC03M014346
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WNT7A on UCSC Golden Path with GeneCards custom track

Genomic Locations for WNT7A Gene

Genomic Locations for WNT7A Gene
63,864 bases
Minus strand

Genomic View for WNT7A Gene

Genes around WNT7A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNT7A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNT7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT7A Gene

Proteins for WNT7A Gene

  • Protein details for WNT7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Wnt-7a
    Protein Accession:
    Secondary Accessions:
    • Q96H90
    • Q9Y560

    Protein attributes for WNT7A Gene

    349 amino acids
    Molecular mass:
    39005 Da
    Quaternary structure:
    • Interacts with PORCN.

    Three dimensional structures from OCA and Proteopedia for WNT7A Gene

neXtProt entry for WNT7A Gene

Post-translational modifications for WNT7A Gene

  • Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at Asn83, posLast=127127, and Asn295
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT7A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WNT7A Gene

Domains & Families for WNT7A Gene

Gene Families for WNT7A Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for WNT7A Gene

Suggested Antigen Peptide Sequences for WNT7A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Wnt family.
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT7A: view

Function for WNT7A Gene

Molecular function for WNT7A Gene

GENATLAS Biochemistry:
wingless-type MMTV integration site 7A,Drosophila wingless (Wg) segment polarity gene homolog,controlling limb development at the dorsoventral axis,modulating cell fate and cell behavior during vertebrate development, upregulating LMX1A expression in limbs mesenchyme and dorsal differentiation
UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the mullerian ducts (By similarity).

LifeMap Function Summary for WNT7A Gene

Phenotypes From GWAS Catalog for WNT7A Gene

Gene Ontology (GO) - Molecular Function for WNT7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 12857724
GO:0005109 frizzled binding IEA,IBA --
GO:0005125 cytokine activity IDA 18986540
GO:0005515 protein binding IPI 22986341
GO:0048018 receptor agonist activity IDA 18986540
genes like me logo Genes that share ontologies with WNT7A: view
genes like me logo Genes that share phenotypes with WNT7A: view

Human Phenotype Ontology for WNT7A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for WNT7A Gene

MGI Knock Outs for WNT7A:

Clone Products

  • Addgene plasmids for WNT7A

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for WNT7A Gene

Localization for WNT7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT7A Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WNT7A gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 4
mitochondrion 4
endoplasmic reticulum 4
cytosol 2
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for WNT7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IBA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005796 Golgi lumen TAS --
genes like me logo Genes that share ontologies with WNT7A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for WNT7A Gene

Pathways & Interactions for WNT7A Gene

genes like me logo Genes that share pathways with WNT7A: view

SIGNOR curated interactions for WNT7A Gene


Gene Ontology (GO) - Biological Process for WNT7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000578 embryonic axis specification IMP 16826533
GO:0001502 cartilage condensation IDA 17202865
GO:0001525 angiogenesis IEA --
GO:0002062 chondrocyte differentiation IDA 17202865
GO:0007269 neurotransmitter secretion IEA --
genes like me logo Genes that share ontologies with WNT7A: view

Drugs & Compounds for WNT7A Gene

(2) Drugs for WNT7A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for WNT7A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with WNT7A: view

Transcripts for WNT7A Gene

mRNA/cDNA for WNT7A Gene

Unigene Clusters for WNT7A Gene

Wingless-type MMTV integration site family, member 7A:
Representative Sequences:

Clone Products

  • Addgene plasmids for WNT7A

Alternative Splicing Database (ASD) splice patterns (SP) for WNT7A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1: - -

Relevant External Links for WNT7A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WNT7A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WNT7A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT7A Gene

This gene is overexpressed in Brain - Cortex (x5.7), Brain - Amygdala (x5.2), Brain - Frontal Cortex (BA9) (x4.9), Brain - Nucleus accumbens (basal ganglia) (x4.3), Brain - Anterior cingulate cortex (BA24) (x4.1), and Brain - Putamen (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for WNT7A Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WNT7A Gene

Protein tissue co-expression partners for WNT7A Gene

NURSA nuclear receptor signaling pathways regulating expression of WNT7A Gene:


SOURCE GeneReport for Unigene cluster for WNT7A Gene:


mRNA Expression by UniProt/SwissProt for WNT7A Gene:

Tissue specificity: Expression is restricted to placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain.

Evidence on tissue expression from TISSUES for WNT7A Gene

  • Nervous system(4.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for WNT7A Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • integumentary
  • nervous
  • reproductive
  • skeletal muscle
  • skeleton
  • urinary
Head and neck:
  • brain
  • cheek
  • chin
  • ear
  • eye
  • eyelid
  • face
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • outer ear
  • scalp
  • skull
  • breast
  • chest wall
  • clavicle
  • heart
  • rib
  • rib cage
  • sternum
  • kidney
  • fallopian tube
  • ovary
  • pelvis
  • penis
  • testicle
  • urethra
  • uterus
  • vagina
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • blood
  • blood vessel
  • coagulation system
  • hair
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with WNT7A: view

Orthologs for WNT7A Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT7A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WNT7A 34
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia WNT7A 34
  • 96 (a)
(Canis familiaris)
Mammalia WNT7A 33 34
  • 95.22 (n)
(Bos Taurus)
Mammalia WNT7A 33 34
  • 94.17 (n)
(Mus musculus)
Mammalia Wnt7a 33 16 34
  • 92.93 (n)
(Rattus norvegicus)
Mammalia Wnt7a 33
  • 91.21 (n)
(Monodelphis domestica)
Mammalia WNT7A 34
  • 74 (a)
(Gallus gallus)
Aves WNT7A 33 34
  • 80.71 (n)
(Anolis carolinensis)
Reptilia WNT7A 34
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wnt7b 33
  • 75.3 (n)
(Danio rerio)
Actinopterygii WNT7A (1 of 2) 34
  • 81 (a)
wnt7aa 33 34
  • 75.93 (n)
fruit fly
(Drosophila melanogaster)
Insecta Wnt2 35 34
  • 49 (a)
(Caenorhabditis elegans)
Secernentea cwn-2 35
  • 42 (a)
egl-20 35
  • 38 (a)
mom-2 35
  • 35 (a)
lin-44 35
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
Species where no ortholog for WNT7A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT7A Gene

Gene Tree for WNT7A (if available)
Gene Tree for WNT7A (if available)

Paralogs for WNT7A Gene

Paralogs for WNT7A Gene

(18) SIMAP similar genes for WNT7A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WNT7A: view

Variants for WNT7A Gene

Sequence variations from dbSNP and Humsavar for WNT7A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs104893832 Pathogenic, Fuhrmann syndrome (FUHRS) [MIM:228930] 13,854,777(-) CCTAC(A/G)CCATC reference, missense
rs104893835 Pathogenic, Limb pelvis hypoplasia aplasia syndrome (LPHAS) [MIM:276820] 13,819,120(-) AGGGC(C/T)GCGCC reference, missense
rs397514643 Pathogenic, Limb pelvis hypoplasia aplasia syndrome (LPHAS) [MIM:276820] 13,819,330(-) AGTTT(C/T)GGGAG reference, missense
rs397514666 Pathogenic, Limb pelvis hypoplasia aplasia syndrome (LPHAS) [MIM:276820] 13,875,031(-) TGGAC(A/G)AGTGT reference, missense
rs879255548 Pathogenic, Limb pelvis hypoplasia aplasia syndrome (LPHAS) [MIM:276820] 13,854,798(-) GGAGC(C/T)GGGAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for WNT7A Gene

Variant ID Type Subtype PubMed ID
esv2063559 CNV deletion 18987734
esv2724944 CNV deletion 23290073
esv34163 CNV loss 18971310
nsv1011766 CNV gain 25217958
nsv1111238 CNV tandem duplication 24896259
nsv1117327 CNV tandem duplication 24896259
nsv3709 CNV insertion 18451855
nsv589767 CNV loss 21841781
nsv589768 CNV loss 21841781
nsv834618 CNV loss 17160897

Variation tolerance for WNT7A Gene

Residual Variation Intolerance Score: 12.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 16.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WNT7A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT7A Gene

Disorders for WNT7A Gene

MalaCards: The human disease database

(10) MalaCards diseases for WNT7A Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
fuhrmann syndrome
  • bowing of the femurs, aplasia or hypoplasia of the fibula, and digital anomalies
ulna and fibula, absence of, with severe limb deficiency
  • al-awadi-raas-rothschild syndrome
humeroradial synostosis
  • humero-radial fusion
persistent mullerian duct syndrome
  • persistent muellerian duct syndrome
- elite association - COSMIC cancer census association via MalaCards
Search WNT7A in MalaCards View complete list of genes associated with diseases


  • Fuhrmann syndrome (FUHRS) [MIM:228930]: Distinct limb-malformation disorder characterized also by various degrees of limb aplasia/hypoplasia and joint dysplasia. {ECO:0000269 PubMed:16826533}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Limb pelvis hypoplasia aplasia syndrome (LPHAS) [MIM:276820]: A syndrome of severe deficiency of the extremities due to hypo- or aplasia of one or more long bones of one or more limbs. Pelvic manifestations include hip dislocation, hypoplastic iliac bone and aplastic pubic bones. Thoracic deformity, unusual facies and genitourinary anomalies can be present. {ECO:0000269 PubMed:16826533, ECO:0000269 PubMed:17431918, ECO:0000269 PubMed:20949531, ECO:0000269 PubMed:21271649, ECO:0000269 PubMed:27638328}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for WNT7A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with WNT7A: view

No data available for Genatlas for WNT7A Gene

Publications for WNT7A Gene

  1. Isolation of a full-length human WNT7A gene implicated in limb development and cell transformation, and mapping to chromosome 3p25. (PMID: 9161407) Bui TD … Harris AL (Gene 1997) 2 3 4 22 60
  2. Isolation, characterization and chromosomal assignment of the human WNT7A gene. (PMID: 8893824) Ikegawa S … Nakamura Y (Cytogenetics and cell genetics 1996) 2 3 4 60
  3. A novel missense mutation, p.(R102W) in WNT7A causes Al-Awadi Raas-Rothschild syndrome in a fetus. (PMID: 27638328) Mutlu MB … Karaman A (European journal of medical genetics 2016) 3 4 60
  4. Al-Awadi-Raas-Rothschild (limb/pelvis/uterus-hypoplasia/aplasia) syndrome and WNT7A mutations: genetic homogeneity and nosological delineation. (PMID: 21271649) Garavelli L … Superti-Furga A (American journal of medical genetics. Part A 2011) 3 4 60
  5. Pathway-based approaches to imaging genetics association studies: Wnt signaling, GSK3beta substrates and major depression. (PMID: 20219685) Inkster B … Matthews PM (NeuroImage 2010) 3 45 60

Products for WNT7A Gene

Sources for WNT7A Gene

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