External Ids for WNT6 Gene
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level. [provided by RefSeq, Jul 2008]
GeneCards Summary for WNT6 Gene
WNT6 (Wingless-Type MMTV Integration Site Family, Member 6) is a Protein Coding gene. Diseases associated with WNT6 include colorectal cancer. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include frizzled binding. An important paralog of this gene is WNT1.
UniProtKB/Swiss-Prot for WNT6 Gene
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway.