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Set Analyses:

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WNT6 Gene

protein-coding GIFtS: 63
GCID: GC02P219724

Wingless-Type MMTV Integration Site Family, Member 6

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Wingless-Type MMTV Integration Site Family, Member 6¹ ²
Protein Wnt-6²

External Ids:	HGNC: 12785¹	Entrez Gene: 7475²	Ensembl: ENSG00000115596⁷	OMIM: 604663⁵	UniProtKB: Q9Y6F9³

Export aliases for WNT6 gene to outside databases

Previous GC identifers: GC02P217740 GC02P218445 GC02P219688 GC02P219927 GC02P219548 GC02P219432 GC02P211579

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WNT6 Gene:

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These

proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell

fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in

cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell

line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered

in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the

amino acid level. (provided by RefSeq, Jul 2008)

GeneCards Summary for WNT6 Gene:

WNT6 (wingless-type MMTV integration site family, member 6) is a protein-coding gene. Diseases associated with WNT6 include cervical cancer, and cervicitis. GO annotations related to this gene include frizzled binding. An important paralog of this gene is WNT5B.

UniProtKB/Swiss-Prot: WNT6_HUMAN, Q9Y6F9

Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental

protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to

signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to

DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000002.12 NC_018913.2 NT_005403.18

Regulatory elements:

Regulatory transcription factor binding sites in the WNT6 gene promoter:
MyoD PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WNT6 promoter sequence

Search Chromatin IP Primers for WNT6

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WNT6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35 Ensembl cytogenetic band: 2q35 HGNC cytogenetic band: 2q35

WNT6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT6 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P219724: view genomic region (about GC identifiers)

Start:	219,724,544 bp from pter	End:	219,738,955 bp from pter
Size:	14,412 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: WNT6_HUMAN, Q9Y6F9 (See protein sequence)

Recommended Name: Protein Wnt-6 precursor

Size: 365 amino acids; 39721 Da

Subunit: Interacts with PORCN (By similarity)

Secondary accessions: Q9H1J6 Q9H238

Explore the universe of human proteins at neXtProt for WNT6: NX_Q9Y6F9

Explore proteomics data for WNT6 at MOPED

Post-translational modifications:

Palmitoylation at Ser-228 is required for efficient binding to frizzled receptors. It is also required for

subsequent palmitoylation at Cys-76. Palmitoylation is necessary for proper trafficking to cell surface (By

similarity)¹

Glycosylation² at Asn86, Asn311

See WNT6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_006513.1

ENSEMBL proteins:

ENSP00000233948

Reactome Protein details: Q9Y6F9

WNT6 Human Recombinant Protein Products:

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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for WNT6 OriGene Custom MassSpec OriGene Custom Protein Services for WNT6
	GenScript Custom Purified and Recombinant Proteins Services for WNT6
	Novus Biologicals WNT6 Protein Novus Biologicals WNT6 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for WNT6

WNT6 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for WNT6 (Wnt-6)
	OriGene Antibodies for WNT6 OriGene Custom Antibody Services for WNT6
	Novus Biologicals WNT6 Antibodies
	Abcam antibodies for WNT6
	Cloud-Clone Corp. Antibodies for WNT6
	ThermoFisher Antibodies for WNT6
	LSBio Antibodies in human, mouse, rat for WNT6

WNT6 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for WNT6
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for WNT6
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for WNT6 Cloud-Clone Corp. CLIAs for WNT6

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

WNT: Wingless-type MMTV integration sites

3 InterPro protein domains:

IPR009143 Wnt6

IPR005817 Wnt

IPR018161 Wnt_CS

Graphical View of Domain Structure for InterPro Entry Q9Y6F9

ProtoNet protein and cluster: Q9Y6F9

1 Blocks protein domain: IPB005816 Secreted growth factor Wnt protein

UniProtKB/Swiss-Prot: WNT6_HUMAN, Q9Y6F9

Similarity: Belongs to the Wnt family

WNT6 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: WNT6_HUMAN, Q9Y6F9

Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental

protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to

signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to

DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway

Genatlas biochemistry entry for WNT6:

wingless-type MMTV integration site 6,Drosophila wingless (wg) segment polarity gene homolog,expressed in

ectoderm,somites,limb and mammary gland in mice,involved in short-range signaling during embryonic patterning

Summary:

During embryonic development, WNT6 as signaling molecule is secreted from the following cells:

Surface Ectoderm: Surface Ectoderm Cells (Surface Ectoderm)

It affects the following cells:

Brain: Meningeal Progenitor Cells (Anterior Meninges)

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	--	--
GO:0005109	frizzled binding	IBA	--

WNT6 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for WNT6:

Cell cycle / mitosis defect

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Wnt6):

cellular

embryogenesis

endocrine/exocrine gland

reproductive system

WNT6 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Wnt6^tm1Akis for WNT6

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WNT6

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for WNT6

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WNT6

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WNT6

miRNA Products:		miRTarBase miRNAs that target WNT6: hsa-mir-9-5p (MIRT021434)

		Block miRNA regulation of human, mouse, rat WNT6 using miScript Target Protectors
		2 qRT-PCR Assays for microRNAs that regulate WNT6:
		hsa-miR-525-5p hsa-miR-520a-5p
		SwitchGear 3'UTR luciferase reporter plasmid: WNT6 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for WNT6
		Predesigned siRNA for gene silencing in human, mouse, rat WNT6

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for WNT6

Clone Products:		OriGene clones in human, mouse for WNT6 (see all 6) OriGene ORF clones in mouse, rat for WNT6 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: WNT6 (NM_006522)
		Sino Biological Human cDNA Clone for WNT6
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for WNT6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for WNT6
		Browse ESI BIO Cell Lines and PureStem Progenitors for WNT6

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT6

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

WNT6_HUMAN, Q9Y6F9: Secreted, extracellular space, extracellular matrix

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	5
plasma membrane	3
golgi apparatus	2

About this image

Gene Ontology (GO): Selected cellular component terms (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005615	extracellular space	IBA	--
GO:0005788	endoplasmic reticulum lumen	TAS	--
GO:0005796	Golgi lumen	TAS	--

WNT6 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for WNT6 About (see all 20)

See pathways by source

SuperPath

Contained pathways About

Wnt Pathway

Wnt Pathway

0.56

WNT ligand biogenesis and trafficking

0.56

Wnt signaling pathway (KEGG)

Wnt signaling pathway

0.40

Wnt Signaling Pathways

0.40

Wnt Signaling Pathway (WikiPathways)

	Wnt Signaling Pathway	0.55			DNA damage response (only ATM dependent)	0.32
	Wnt Signaling Pathway and Pluripotency	0.55

Basal cell carcinoma

	Basal cell carcinoma	0.43			Melanogenesis	0.32
	Hedgehog signaling pathway	0.43

Signaling by GPCR

Signaling by GPCR

0.90

Signal Transduction

0.58

Pathways by source See SuperPaths
Show all pathways

1 R&D Systems Pathway for WNT6

Wnt Signaling Pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for WNT6 (see all 7)

	GSK3 Signaling
	Presenilin-Mediated Signaling
	Colorectal Cancer Metastasis
	Human Embryonic Stem Cell Pluripotency
	Nanog in Mammalian ESC Pluripotency

1 Tocris Bioscience Pathway for WNT6

Wnt Pathway

2 GeneGo (Thomson Reuters) Pathways for WNT6

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

3 BioSystems Pathways for WNT6

	Wnt Signaling Pathway
	Wnt Signaling Pathway and Pluripotency
	DNA damage response (only ATM dependent)

2 Sino Biological Pathways for WNT6

	Canonical Wnt Pathway
	Non-Canonical Wnt Pathway

2 Reactome Pathways for WNT6

	WNT ligand biogenesis and trafficking
	Class B/2 (Secretin family receptors)

Selected Kegg Pathways (Kegg details for WNT6) (see all 8):

	Wnt signaling pathway
	Hedgehog signaling pathway
	Hippo signaling pathway
	Melanogenesis
	HTLV-I infection

WNT6 for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Arrays including WNT6:

Notch Signaling Targets in human mouse rat

Hedgehog Signaling Pathway in human mouse rat

WNT Signaling Pathway in human mouse rat

Signal Transduction PathwayFinder in human mouse rat

Interactions:

GeneGlobe Interaction Network for WNT6

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for WNT6 (Q9Y6F9³ ENSP00000233948⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 37)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PORCN	Q9H237³, ENSP00000322304⁴	I2D: score=4 STRING: ENSP00000322304
CER1	ENSP00000370297⁴	STRING: ENSP00000370297
FZD1	ENSP00000287934⁴	STRING: ENSP00000287934
FZD10	ENSP00000229030⁴	STRING: ENSP00000229030
FZD2	ENSP00000323901⁴	STRING: ENSP00000323901

About this table

Gene Ontology (GO): Selected biological process terms (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001658	branching involved in ureteric bud morphogenesis	IEA	--
GO:0007267	cell-cell signaling	--	--
GO:0007275	multicellular organismal development	--	--
GO:0009798	axis specification	IEA	--
GO:0010628	positive regulation of gene expression	IMP	--

WNT6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for WNT6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for WNT6 gene:

NM_006522.3

Unigene Cluster for WNT6:

Wingless-type MMTV integration site family, member 6

Hs.29764 [show with all ESTs]

Unigene Representative Sequence: AY009401

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000233948(uc002vjc.1) ENST00000486233

miRNA Products:		Block miRNA regulation of human, mouse, rat WNT6 using miScript Target Protectors
		2 qRT-PCR Assays for microRNAs that regulate WNT6:
		hsa-miR-525-5p hsa-miR-520a-5p
		SwitchGear 3'UTR luciferase reporter plasmid: WNT6 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for WNT6
		Predesigned siRNA for gene silencing in human, mouse, rat WNT6

Clone Products:		OriGene clones in human, mouse for WNT6 (see all 6) OriGene ORF clones in mouse, rat for WNT6 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: WNT6 (NM_006522)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for WNT6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT6

Primer Products:		OriGene qPCR primer pairs and template standards for WNT6 OriGene qSTAR qPCR primer pairs in human, mouse for WNT6
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat WNT6
		QuantiTect SYBR Green Assays in human, mouse, rat WNT6
		QuantiFast Probe-based Assays in human, mouse, rat WNT6

Additional mRNA sequence:

AB059570.1 AK075522.1 AY009401.1 BC004329.1 BT007456.1

3 DOTS entries:

DT.112442 DT.91749172 DT.92013055

Selected AceView cDNA sequences (see all 28):

AI218134 R78502 BU727755 BC004329 BF568080 BM720290 BM849242 AK075522

BM763339 BE392594 AY009401 BM687468 BT007456 NM_006522 AB059570 BF568920

BE744521 BF058854 BE410061 CD673352 BE382983 AA745754 AW128858 BF057511

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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WNT6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GGCACCAACG

About this image

WNT6 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 10) fully expand


Tooth (Integumentary System) fully expand to see all 6 entries
Dental Placode Cells Dental Placode
Dental Papilla

Epithelial Cells
Intermediate Keratinocytes Embryonic Epidermis

Kidney (Urinary System) fully expand to see all 2 entries
Ureteric Bud Tip Cells Ureteric Bud
Ureteric Bud

Epidermis (Integumentary System) fully expand to see all 2 entries
Intermediate Keratinocytes Embryonic Epidermis

Hair
Primary Hair Placode Cells Hair Follicle

WNT6 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

WNT6 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.29764

UniProtKB/Swiss-Prot: WNT6_HUMAN, Q9Y6F9

Tissue specificity: Expressed in gastric cancer cell lines and gastric cancer tissues (at protein level). Detected

in the apical gland region of the gastric foveolar epithelium (at protein level)

Pathway & Disease-focused RT² Profiler PCR Arrays including WNT6:

Notch Signaling Targets in human mouse rat

Hedgehog Signaling Pathway in human mouse rat

WNT Signaling Pathway in human mouse rat

Signal Transduction PathwayFinder in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for WNT6 OriGene qSTAR qPCR primer pairs in human, mouse for WNT6
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat WNT6
		QuantiTect SYBR Green Assays in human, mouse, rat WNT6
		QuantiFast Probe-based Assays in human, mouse, rat WNT6

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for WNT6 gene from Selected species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Wnt6^{1 , 5}	wingless-related MMTV integration site 6^{1, 5}	87.57(n)¹ 97.98(a)¹		1 (38.54 cM)⁵ 22420¹ NM_009526.3¹ NP_033552.2¹ 74771892⁵
chicken (Gallus gallus)	Aves	WNT6¹	wingless-type MMTV integration site family, member more	74.9(n) 74.69(a)		395235 NM_001007594.2 NP_001007595.1
lizard (Anolis carolinensis)	Reptilia	WNT6⁶	wingless-type MMTV integration site family, member...	75(a)	1 ↔ 1	AAWZ02035345(13351-46878)
zebrafish (Danio rerio)	Actinopterygii	wnt6b¹	wingless-type MMTV integration site family, member more	68.06(n) 73.13(a)		561831 XM_003199189.2 XP_003199237.2
fruit fly (Drosophila melanogaster)	Insecta	Wnt6^{1 , 3}	frizzled-2 receptor signaling pathway signal transducer³ Wnt oncogene analog 6¹	49(a)³ 58.39(n)¹ 49.06(a)¹		27F3³ 34010¹ NM_001273259.1¹ NP_001260188.1¹
worm (Caenorhabditis elegans)	Secernentea	cwn-1⁶	Protein CWN-1, isoform b (cwn-1) mRNA, complete cd...	33(a)	1 → many	II(130983-133592) WBGene00000857

ENSEMBL Gene Tree for WNT6 (if available)
TreeFam Gene Tree for WNT6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for WNT6 gene

WNT5B² WNT16² WNT5A² WNT11² WNT2² WNT2B² WNT3A² WNT1²

WNT4² WNT7A² WNT7B² WNT3²

18 SIMAP similar genes for WNT6 using alignment to 2 protein entries: WNT6_HUMAN (see all proteins):

WNT4 WNT2B WNT2 WNT7B WNT5A WNT3

WNT9B WNT5B WNT1 WNT11 WNT7A WNT3A

WNT10B WNT8B WNT8A WNT10A WNT9A WNT16

WNT6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs690877^1,2	C,F,A,H	--	219722664(+)	`ACCTGC/TAGCCT`	1	--	us2k¹		28		NA EA NS WA CSA	2379
rs190230497^1,2	C	--	219722736(+)	`AAACTC/GGGTAT`	1	--	us2k¹		0	--	--	--	--
rs148829824^1,2		--	219722802(+)	`TGGCAC/TTGCCC`	1	--	us2k¹		0	--	--	--	--
rs181882535^1,2		--	219722809(+)	`GCCCCA/GTAGAA`	1	--	us2k¹		0	--	--	--	--
rs146922347^1,2		--	219723107(+)	`TCATTC/TCTTCC`	1	--	us2k¹		0	--	--	--	--
rs77978159^1,2	F	--	219723268(+)	`GAAGCG/AACCTC`	1	--	us2k¹		1		WA	118
rs115120255^1,2	C,F	--	219723379(+)	`AGGACA/GGCTTT`	1	--	us2k¹		1		WA	118
rs9808011^1,2	C,F,H	--	219723431(+)	`TCCCAC/TACCAC`	1	--	us2k¹ tfbs³		6		NS NA WA	906
rs185320226^1,2		--	219723447(+)	`CCTTGA/GCACCC`	1	--	us2k¹		0	--	--	--	--
rs137891922^1,2	C	--	219723698(+)	`CTCTTA/GGACAC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for WNT6 (219724544 - 219738955 bp)

Structural Variations
Database of Genomic Variants (DGV) 4 variations for WNT6: About this table

Variant ID	Type	Subtype	PubMed ID
dgv4436n71	CNV	Loss	21882294
nsv875864	CNV	Loss	21882294
nsv875867	CNV	Loss	21882294
nsv834542	CNV	Gain	17160897

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 604663 OMIM disorders: --

10 diseases for WNT6:
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cervical cancer cervicitis colorectal cancer ectodermal dysplasia

labyrinthitis basal cell carcinoma meningitis adenoma

malaria neuronitis

WNT6 for disorders About GeneDecksing

Genetic Association Database (GAD): WNT6
Human Genome Epidemiology (HuGE) Navigator: WNT6 (2 documents)

Export disorders for WNT6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for WNT6 gene, integrated from 10 sources (see all 23):
(articles sorted by number of sources associating them with WNT6)

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WNT10A and WNT6, clustered in human chromosome 2q35 region with head- to-tail manner, are strongly co-expressed in SW480 cells. (PubMed id 11350055)^{1, 2, 3, 9} Kirikoshi H.... Katoh M. (Biochem. Biophys. Res. Commun. 2001)
Partial cloning and assignment of WNT6 to human chromosome band 2q35 by in situ hybridization. (PubMed id 10343101)^{1, 2, 3} Rankin J.... Lindsay S. (Cytogenet. Cell Genet. 1999)
WNT6 is a novel target gene of caveolin-1 promoting chemoresistance to epirubicin in human gastric cancer cells. (PubMed id 22370641)^{1, 2} Yuan G....Burgermeister E. (Oncogene 2013)
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)^{1, 4} Jugessur A....Murray J.C. (PLoS ONE 2010)
Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations. (PubMed id 16953426)^{1, 4} Beaty T.H....Scott A.F. (Hum. Genet. 2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Polymorphisms in WNT6 and WNT10A and colorectal adenoma risk. (PubMed id 21547848)¹ Galbraith R.L....Ulrich C.M. (Nutr Cancer 2011)
Effect of Wnt6 on human dental papilla cells in vitro. (PubMed id 20113781)¹ Wang C....Ye L. (J Endod 2010)
Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: the odonto-onycho-dermal dysplasia. (PubMed id 17847007)¹ Adaimy L.... Megarbane A. (Am. J. Hum. Genet. 2007)
Expression patterns of Wnt genes during development of an anterior part of the chicken eye. (PubMed id 16258938)¹ Fokina V.M. and Frolova E.I. (Dev. Dyn. 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7475	HGNC: 12785	AceView: WNT6	Ensembl:ENSG00000115596	euGenes: HUgn7475
ECgene: WNT6	Kegg: 7475	H-InvDB: WNT6

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for WNT6	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for WNT6	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for WNT6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for WNT6 gene:
Search GeneIP for patents involving WNT6

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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WNT6 Gene

Wingless-Type MMTV Integration Site Family, Member 6

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Wingless-Type MMTV Integration Site Family, Member 6

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