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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WNT6 Gene

protein-coding   GIFtS: 63
GCID: GC02P219724

Wingless-Type MMTV Integration Site Family, Member 6
  5 related diseases
at
MalaCards
 

Aliases
for WNT6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Wingless-Type MMTV Integration Site Family, Member 61 2
Protein Wnt-62

External Ids:    HGNC: 127851   Entrez Gene: 74752   Ensembl: ENSG000001155967   OMIM: 6046635   UniProtKB: Q9Y6F93   

Export aliases for WNT6 gene to outside databases

Previous GC identifers: GC02P217740 GC02P218445 GC02P219688 GC02P219927 GC02P219548 GC02P219432 GC02P211579


Summaries
for WNT6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for WNT6 Gene:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These
proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell
fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in
cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell
line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered
in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the
amino acid level. (provided by RefSeq, Jul 2008)

GeneCards Summary for WNT6 Gene: 
WNT6 (wingless-type MMTV integration site family, member 6) is a protein-coding gene. Diseases associated with WNT6 include cervical cancer, and cervicitis, and among its related super-pathways are Basal cell carcinoma and Wnt signaling pathway. GO annotations related to this gene include G-protein coupled receptor binding. An important paralog of this gene is WNT5B.

UniProtKB/Swiss-Prot: WNT6_HUMAN, Q9Y6F9
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental
protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to
signal over only few cell diameters




Genomic Views
for WNT6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WNT6 gene promoter:
         MyoD   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WNT6 promoter sequence
   Search SABiosciences Chromatin IP Primers for WNT6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WNT6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

WNT6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT6 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P219724:  view genomic region     (about GC identifiers)

Start:
 219,724,544 bp from pter      End:
 219,738,955 bp from pter
Size:
 14,412 bases      Orientation:
 plus strand

Proteins
for WNT6 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: WNT6_HUMAN, Q9Y6F9 (See protein sequence)
Recommended Name: Protein Wnt-6 precursor  
Size: 365 amino acids; 39721 Da
Subunit: Interacts with PORCN (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix
Secondary accessions: Q9H1J6 Q9H238

Explore the universe of human proteins at neXtProt for WNT6: NX_Q9Y6F9

Explore proteomics data for WNT6 at MOPED 

Post-translational modifications:

  • UniProtKB: Palmitoylation at Ser-228 is required for efficient binding to frizzled receptors. It is also required for
    subsequent palmitoylation at Cys-76. Palmitoylation is necessary for proper trafficking to cell surface (By
    similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y6F9

    • WNT6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WNT6 Protein Expression
    REFSEQ proteins: NP_006513.1  
    ENSEMBL proteins: 
     ENSP00000233948  
    Reactome Protein details: Q9Y6F9
    Human Recombinant Protein Products for WNT6: 
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    OriGene Protein Over-expression Lysate for WNT6
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for WNT6
    GenScript Custom Purified and Recombinant Proteins Services for WNT6
    Novus Biologicals WNT6 Protein
    Novus Biologicals WNT6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WNT6 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IBA--
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005796Golgi lumen TAS--

    WNT6 for ontologies           About GeneDecksing



    WNT6 Antibody Products: 
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    Abcam antibodies for WNT6
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    LSBio Antibodies in human, mouse, rat for WNT6 

    Assay Products for WNT6: 
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    Cloud-Clone Corp. ELISAs for WNT6 
    Cloud-Clone Corp. CLIAs for WNT6

    Protein Domains /
    Families
    for WNT6 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    WNT: Wingless-type MMTV integration sites

    3 InterPro protein domains:
     IPR009143 Wnt6
     IPR005817 Wnt
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry Q9Y6F9

    ProtoNet protein and cluster: Q9Y6F9

    1 Blocks protein domain: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WNT6_HUMAN, Q9Y6F9
    Similarity: Belongs to the Wnt family


    WNT6 for domains           About GeneDecksing


    Function
    for WNT6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WNT6_HUMAN, Q9Y6F9
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental
    protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to
    signal over only few cell diameters

         Genatlas biochemistry entry for WNT6:
    wingless-type MMTV integration site 6,Drosophila wingless (wg) segment polarity gene homolog,expressed in
    ectoderm,somites,limb and mammary gland in mice,involved in short-range signaling during embryonic patterning

         Summary:
    During embryonic development, WNT6 as signaling molecule is secreted from the following cells: Surface Ectoderm Cells in Surface Ectoderm It affects the following cells: Meningeal Progenitor Cells in Anterior Meninges

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005109frizzled binding IBA--
         
    WNT6 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for WNT6:
     Cell cycle / mitosis defect 

         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Wnt6):
     cellular  embryogenesis  endocrine/exocrine gland  reproductive system 

    WNT6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Wnt6tm1Akis for WNT6

       inGenious Targeting Laboratory - Custom generated mouse model solutions for WNT6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for WNT6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WNT6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WNT6 

    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WNT6
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate WNT6:
    hsa-miR-525-5p hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: WNT6 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for WNT6
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of WNT6

    Clone
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    GenScript: all cDNA clones in your preferred vector: WNT6 (NM_006522)
    Sino Biological Human cDNA Clone for WNT6
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT6
    Sirion Biotech Customized lentivirus for stable overexpression of WNT6 
                         Customized lentivirus expression plasmids for stable overexpression of WNT6 

    Cell Line
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    Search LifeMap BioReagents cell lines for WNT6
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT6


    Pathways & Interactions
    for WNT6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for WNT6 About   (see all 19)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Basal cell carcinoma
    		Hedgehog signaling pathway0.43
    		Wnt Pathway0.39
    		Basal cell carcinoma0.43
    		Melanogenesis0.32
    2Wnt signaling pathway
    		Wnt signaling pathway0.40
    		Wnt Signaling Pathway0.40
    3Wnt Signaling Pathway
    		Wnt Signaling Pathway0.55
    		DNA damage response (only ATM dependent)0.32
    		Wnt Signaling Pathway and Pluripotency0.55
    4Signaling by GPCR
    		Signaling by GPCR0.90
    		Signal Transduction0.55
    5Asparagine N-linked glycosylation
    		WNT ligand biogenesis and trafficking0.77
    		Signaling by Wnt0.62

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for WNT6
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    1 R&D Systems Pathway for WNT6
        Wnt Signaling Pathway

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for WNT6 (see all 7)
        GSK3 Signaling
    Presenilin-Mediated Signaling
    Colorectal Cancer Metastasis
    Human Embryonic Stem Cell Pluripotency
    Nanog in Mammalian ESC Pluripotency

    1 Tocris Bioscience Pathway for WNT6
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT6
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    3 BioSystems Pathways for WNT6
        Wnt Signaling Pathway
    DNA damage response (only ATM dependent)
    Wnt Signaling Pathway and Pluripotency

    2 Sino Biological Pathways for WNT6 
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    5/6        Reactome Pathways for WNT6 (see all 6)
        Signaling by Wnt
    Signal Transduction
    Signaling by GPCR
    WNT ligand biogenesis and trafficking
    GPCR ligand binding


    5/8         Kegg Pathways  (Kegg details for WNT6) (see all 8):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection


    WNT6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WNT6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/17 Interacting proteins for WNT6 (Q9Y6F93 ENSP000002339484) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PORCNQ9H2373, ENSP000003223044I2D: score=4 STRING: ENSP00000322304
    CER1ENSP000003702974STRING: ENSP00000370297
    FZD1ENSP000002879344STRING: ENSP00000287934
    FZD10ENSP000002290304STRING: ENSP00000229030
    FZD2ENSP000003239014STRING: ENSP00000323901
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001658branching involved in ureteric bud morphogenesis IEA--
    GO:0007267cell-cell signaling NAS--
    GO:0007275multicellular organismal development ----
    GO:0009798axis specification IEA--
    GO:0010628positive regulation of gene expression IMP--

    WNT6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for WNT6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for WNT6:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WNT6

    Search CenterWatch for drugs/clinical trials and news about WNT6

    Transcripts
    for WNT6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for WNT6 gene: 
    NM_006522.3  

    Unigene Cluster for WNT6:

    Wingless-type MMTV integration site family, member 6
    Hs.29764  [show with all ESTs]
    Unigene Representative Sequence: AY009401
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000233948(uc002vjc.1) ENST00000486233
    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate WNT6:
    hsa-miR-525-5p hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: WNT6 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for WNT6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WNT6
    Clone
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    GenScript: all cDNA clones in your preferred vector: WNT6 (NM_006522)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WNT6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT6
    Sirion Biotech Customized lentivirus for stable overexpression of WNT6 
                         Customized lentivirus expression plasmids for stable overexpression of WNT6 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WNT6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WNT6

    Additional mRNA sequence: 

    AB059570.1 AK075522.1 AY009401.1 BC004329.1 BT007456.1 

    3 DOTS entries:

    DT.112442  DT.91749172  DT.92013055 

    24/28 AceView cDNA sequences (see all 28):

    BU727755 BM720290 AI218134 R78502 BF568080 BC004329 BM849242 AK075522 
    BM763339 AB059570 BE392594 BM687468 AY009401 NM_006522 BT007456 CD673352 
    BF568920 BF058854 BE410061 BE744521 AA745754 BE382983 AW128858 AA807187 

    GeneLoc Exon Structure


    Expression
    for WNT6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WNT6 expression in normal human tissues (normalized intensities)      WNT6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCACCAACG
    WNT6 Expression
    About this image


    WNT6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/21 selected tissues (see all 21) fully expand
     
     Hair
             Primary Hair Placode Cells Hair Follicle
             mouse/organ system/integumental system   
     
     Tooth (Integumentary System)    fully expand to see all 3 entries
             Dental Papilla
             mouse/organ system/integumental system   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             Immature Schwann Cells Peripheral Nerve Domain
             spinal/ganglion/dorsal root ganglion   
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Ureteric Bud Tip Cells Ureteric Bud
             Ureteric Bud
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   

    See WNT6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WNT6

    SOURCE GeneReport for Unigene cluster: Hs.29764
        SABiosciences Expression via Pathway-Focused PCR Arrays including WNT6: 
              Notch Signaling Targets in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WNT6
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT6

    Orthologs
    for WNT6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for WNT6 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Wnt61 , 5 wingless-related MMTV integration site 61, 5 87.45(n)1
    97.8(a)1    		   1 (38.54 cM)5
    224201  NM_009526.31  NP_033552.21 
     747718925 
    chicken
    (Gallus gallus)    		 Aves WNT61 wingless-type MMTV integration site family, member more 75.52(n)
    75.62(a)    		   395235  NM_001007594.2  NP_001007595.1 
    lizard
    (Anolis carolinensis)    		 Reptilia WNT66
    		 Protein Wnt
    		 75(a)
    		 1 ↔ 1
    		 AAWZ02035345(13351-46878)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5618311 novel protein similar to vertebrate wingless-type MMTV more 67.76(n)
    73.21(a)    		   561831  XM_003199189.1  XP_003199237.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Wnt61 , 3 frizzled-2 receptor signaling pathway
    signal transducer3
    CG4969-PB1    		 49(a)3
    54.31(n)1
    45.22(a)1    		   27F33
    340101  NM_135264.31  NP_609108.31 


    ENSEMBL Gene Tree for WNT6 (if available)
    TreeFam Gene Tree for WNT6 (if available)

    Paralogs
    for WNT6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WNT6 gene
    WNT5B2  WNT162  WNT5A2  WNT112  WNT22  WNT2B2  WNT3A2  WNT12  
    WNT42  WNT10B2  WNT7A2  WNT7B2  WNT32  WNT10A2  
    18 SIMAP similar genes for WNT6 using alignment to 2 protein entries:     WNT6_HUMAN (see all proteins):
    WNT4    WNT2B    WNT2    WNT7B    WNT5A    WNT3
    WNT9B    WNT5B    WNT1    WNT11    WNT7A    WNT3A
    WNT10B    WNT8B    WNT8A    WNT10A    WNT9A    WNT16

    WNT6 for paralogs           About GeneDecksing



    Genomic Variants
    for WNT6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/245 SNPs in WNT6 are shown (see all 245)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs6908771,2
    		C,F,A,H--219722664(+) ACCTGC/TAGCCT 1 -- us2k128Minor allele frequency- T:0.21NA EA NS WA CSA 2379
    rs1902304971,2
    		C--219722736(+) AAACTC/GGGTAT 1 -- us2k10--------
    rs1488298241,2
    		--219722802(+) TGGCAC/TTGCCC 1 -- us2k10--------
    rs1818825351,2
    		--219722809(+) GCCCCA/GTAGAA 1 -- us2k10--------
    rs1469223471,2
    		--219723107(+) TCATTC/TCTTCC 1 -- us2k10--------
    rs779781591,2
    		F--219723268(+) GAAGCG/AACCTC 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1151202551,2
    		C,F--219723379(+) AGGACA/GGCTTT 1 -- us2k11Minor allele frequency- G:0.14WA 118
    rs98080111,2
    		C,F,H--219723431(+) TCCCAC/TACCAC 1 -- us2k1 tfbs36Minor allele frequency- T:0.05NS NA WA 906
    rs1853202261,2
    		--219723447(+) CCTTGA/GCACCC 1 -- us2k10--------
    rs1378919221,2
    		C--219723698(+) CTCTTA/GGACAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for WNT6 (219724544 - 219738955 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for WNT6:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv4436n71CNV Loss21882294
    nsv875864CNV Loss21882294
    nsv875867CNV Loss21882294
    nsv834542CNV Gain17160897

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    Disorders / Diseases
    for WNT6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 604663    OMIM disorders: --

    5 diseases for WNT6:    About MalaCards
    cervical cancer    cervicitis    colorectal cancer    ectodermal dysplasia
    basal cell carcinoma


    WNT6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): WNT6
    Human Genome Epidemiology (HuGE) Navigator: WNT6 (2 documents)

    Export disorders for WNT6 gene to outside databases

    Publications
    for WNT6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WNT6 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with WNT6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. WNT10A and WNT6, clustered in human chromosome 2q35 region with head- to-tail manner, are strongly co-expressed in SW480 cells. (PubMed id 11350055)1, 2, 3, 9 Kirikoshi H.... Katoh M. (2001)
    2. Partial cloning and assignment of WNT6 to human chromosome band 2q35 by in situ hybridization. (PubMed id 10343101)1, 2, 3 Rankin J.... Lindsay S. (1999)
    3. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    4. Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations. (PubMed id 16953426)1, 4 Beaty T.H....Scott A.F. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. WNT6 is a novel target gene of caveolin-1 promoting ch emoresistance to epirubicin in human gastric cancer cells. (PubMed id 22370641)1 Yuan G....Burgermeister E. (2013)
    7. Polymorphisms in WNT6 and WNT10A and colorectal adeno ma risk. (PubMed id 21547848)1 Galbraith R.L....Ulrich C.M. (2011)
    8. Effect of Wnt6 on human dental papilla cells in vitro . (PubMed id 20113781)1 Wang C....Ye L. (2010)
    9. Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: the odonto-onycho-dermal dysplasia. (PubMed id 17847007)1 Adaimy L.... Megarbane A. (2007)
    10. Expression patterns of Wnt genes during development of an anterior part of the chicken eye. (PubMed id 16258938)1 Fokina V.M. and Frolova E.I. (2006)

    External Searches for WNT6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing WNT6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7475 HGNC: 12785 AceView: WNT6 Ensembl:ENSG00000115596 euGenes: HUgn7475
    ECgene: WNT6 Kegg: 7475 H-InvDB: WNT6

    Other Databases showing WNT6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing WNT6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WNT6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT6 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for WNT6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for WNT6 gene:
    Search GeneIP for patents involving WNT6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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