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WNT6 Gene(Protein Coding)

Wnt Family Member 6

GCID:
GC02P218859
GIFtS:
63
Genes Participants
UDN Logo

Aliases for WNT6 Gene

Aliases for WNT6 Gene

  • Wnt Family Member 6 2 3
  • Wingless-Type MMTV Integration Site Family, Member 6 2
  • Wingless-Type MMTV Integration Site Family Member 6 5

External Ids for WNT6 Gene

Previous GeneCards Identifiers for WNT6 Gene

  • GC02P217740
  • GC02P218445
  • GC02P219688
  • GC02P219927
  • GC02P219548
  • GC02P219432
  • GC02P219724
  • GC02P211579

Summaries for WNT6 Gene

Entrez Gene Summary for WNT6 Gene

  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT6 Gene

WNT6 (Wnt Family Member 6) is a Protein Coding gene. Diseases associated with WNT6 include Gastric Cancer. Among its related pathways are HTLV-I infection and Presynaptic function of Kainate receptors. GO annotations related to this gene include receptor binding and frizzled binding. An important paralog of this gene is WNT5B.

UniProtKB/Swiss-Prot for WNT6 Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT6 Gene

Genomics for WNT6 Gene

Products:

  1. Regulatory Element

Regulatory Elements for WNT6 Gene

Enhancers for WNT6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WNT6 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the WNT6 gene promoter:

Genomic Location for WNT6 Gene

Chromosome:
2
Start:
218,859,821 bp from pter
End:
218,874,233 bp from pter
Size:
14,413 bases
Orientation:
Plus strand

Genomic View for WNT6 Gene

Genes around WNT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNT6 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for WNT6 Gene

Proteins for WNT6 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for WNT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6F9-WNT6_HUMAN
    Recommended name:
    Protein Wnt-6
    Protein Accession:
    Q9Y6F9
    Secondary Accessions:
    • Q9H1J6
    • Q9H238

    Protein attributes for WNT6 Gene

    Size:
    365 amino acids
    Molecular mass:
    39721 Da
    Quaternary structure:
    • Interacts with PORCN.

neXtProt entry for WNT6 Gene

Proteomics data for WNT6 Gene at MOPED

Protein Expression for WNT6 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for WNT6 Gene

  • Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at Asn 86 and Asn 311
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for WNT6

No data available for DME Specific Peptides for WNT6 Gene

Domains & Families for WNT6 Gene

Gene Families for WNT6 Gene

HGNC:

Protein Domains for WNT6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for WNT6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6F9

UniProtKB/Swiss-Prot:

WNT6_HUMAN :
  • Belongs to the Wnt family.
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT6: view

Function for WNT6 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for WNT6 Gene

GENATLAS Biochemistry:
wingless-type MMTV integration site 6,Drosophila wingless (wg) segment polarity gene homolog,expressed in ectoderm,somites,limb and mammary gland in mice,involved in short-range signaling during embryonic patterning
UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway.

LifeMap Function Summary for WNT6 Gene

During embryonic development, WNT6 as signaling molecule is secreted from the following cells

Gene Ontology (GO) - Molecular Function for WNT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
genes like me logo Genes that share ontologies with WNT6: view

Phenotypes for WNT6 Gene

MGI mutant phenotypes for WNT6:
inferred from 1 alleles
GenomeRNAi human phenotypes for WNT6:
genes like me logo Genes that share phenotypes with WNT6: view

Animal Models for WNT6 Gene

MGI Knock Outs for WNT6:

Animal Model Products

  • Taconic Biosciences Mouse Models for WNT6

miRNA for WNT6 Gene

miRTarBase miRNAs that target WNT6

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WNT6 Gene

Localization for WNT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT6 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WNT6 Gene COMPARTMENTS Subcellular localization image for WNT6 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
endoplasmic reticulum 4
plasma membrane 4

Gene Ontology (GO) - Cellular Components for WNT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
genes like me logo Genes that share ontologies with WNT6: view

Pathways & Interactions for WNT6 Gene

genes like me logo Genes that share pathways with WNT6: view

Interacting Proteins for WNT6 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000233948%0d%0a9606.ENSP00000290015%0d%0a9606.ENSP00000301061%0d%0a9606.ENSP00000340677%0d%0a9606.ENSP00000325526%0d%0a9606.ENSP00000381739%0d%0a
Selected Interacting proteins: ENSP00000233948 Q9Y6F9-WNT6_HUMAN for WNT6 Gene via STRING I2D

SIGNOR curated interactions for WNT6 Gene

Activates:

Gene Ontology (GO) - Biological Process for WNT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001658 branching involved in ureteric bud morphogenesis IEA --
GO:0010628 positive regulation of gene expression IEA,IMP 20113781
GO:0016055 Wnt signaling pathway IEA,TAS --
GO:0030182 neuron differentiation ISS --
GO:0042475 odontogenesis of dentin-containing tooth IMP 20113781
genes like me logo Genes that share ontologies with WNT6: view

Drugs & Compounds for WNT6 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for WNT6 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for WNT6 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(28) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WNT6 Gene

Wingless-type MMTV integration site family, member 6:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WNT6 Gene

No ASD Table

Relevant External Links for WNT6 Gene

GeneLoc Exon Structure for
WNT6
ECgene alternative splicing isoforms for
WNT6

Expression for WNT6 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for WNT6 Gene

mRNA expression in normal human tissues for WNT6 Gene
mRNA expression by BioGPS for WNT6 GenemRNA expression by GTEx for WNT6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT6 Gene

This gene is overexpressed in Nerve - Tibial (x8.4).

Protein differential expression in normal tissues from HIPED for WNT6 Gene

This gene is overexpressed in Spinal cord (27.6), Testis (19.1), Placenta (9.8), and Ovary (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WNT6 Gene



SOURCE GeneReport for Unigene cluster for WNT6 Gene Hs.29764

mRNA Expression by UniProt/SwissProt for WNT6 Gene

Q9Y6F9-WNT6_HUMAN
Tissue specificity: Expressed in gastric cancer cell lines and gastric cancer tissues (at protein level). Detected in the apical gland region of the gastric foveolar epithelium (at protein level).
genes like me logo Genes that share expression patterns with WNT6: view

Protein tissue co-expression partners for WNT6 Gene

Primer Products

Orthologs for WNT6 Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia WNT6 35
  • 90.96 (n)
  • 97.81 (a)
WNT6 36
  • 98 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia WNT6 35
  • 92.15 (n)
  • 98.49 (a)
WNT6 36
  • 98 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Wnt6 35
  • 87.57 (n)
  • 97.98 (a)
Wnt6 16
Wnt6 36
  • 98 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia WNT6 35
  • 99.56 (n)
  • 100 (a)
rat
(Rattus norvegicus)
 Mammalia Wnt6 35
  • 86.9 (n)
  • 98.27 (a)
oppossum
(Monodelphis domestica)
 Mammalia WNT6 36
  • 93 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia WNT6 36
  • 88 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves WNT6 35
  • 74.9 (n)
  • 74.69 (a)
WNT6 36
  • 75 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia WNT6 36
  • 75 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii wnt6b 35
  • 68.06 (n)
  • 73.13 (a)
wnt6b 36
  • 71 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta Wnt6 37
  • 49 (a)
Wnt6 35
  • 58.39 (n)
  • 49.06 (a)
Wnt6 36
  • 39 (a)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP009733 35
  • 63.22 (n)
  • 55.6 (a)
worm
(Caenorhabditis elegans)
 Secernentea cwn-1 36
  • 33 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 26 (a)
 ManyToMany
Species with no ortholog for WNT6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for WNT6 Gene

ENSEMBL:
Gene Tree for WNT6 (if available)
TreeFam:
Gene Tree for WNT6 (if available)

Paralogs for WNT6 Gene

Paralogs for WNT6 Gene

(18) SIMAP similar genes for WNT6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with WNT6: view

Variants for WNT6 Gene

Sequence variations from dbSNP and Humsavar for WNT6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs688252 -- 218,866,322(-) ACTGA(G/T)GCCAA intron-variant, upstream-variant-2KB
rs690877 -- 218,857,941(+) ACCTG(C/T)AGCCT upstream-variant-2KB
rs744092 -- 218,862,590(+) GTTGG(C/T)CAGGC intron-variant
rs6747776 -- 218,860,595(+) GACGA(C/G)AGAGG intron-variant
rs6754599 -- 218,867,420(+) CTACA(C/G)ATATT intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for WNT6 Gene

Variant ID Type Subtype PubMed ID
nsv875864 CNV Loss 21882294
nsv834542 CNV Gain 17160897
dgv4436n71 CNV Loss 21882294
nsv875867 CNV Loss 21882294

Variation tolerance for WNT6 Gene

Gene Damage Index Score: 3.13; 51.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WNT6 Gene

Human Gene Mutation Database (HGMD)
WNT6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT6 Gene

Disorders for WNT6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for WNT6 Gene - From: GeneCards

Disorder Aliases PubMed IDs
gastric cancer
  • stomach cancer
- elite association - COSMIC cancer census association via MalaCards
Search WNT6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for WNT6

Genetic Association Database (GAD)
WNT6
Human Genome Epidemiology (HuGE) Navigator
WNT6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WNT6
genes like me logo Genes that share disorders with WNT6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WNT6 Gene

Publications for WNT6 Gene

  1. WNT10A and WNT6, clustered in human chromosome 2q35 region with head- to-tail manner, are strongly co-expressed in SW480 cells. (PMID: 11350055) Kirikoshi H. … Katoh M. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 23 67
  2. Partial cloning and assignment of WNT6 to human chromosome band 2q35 by in situ hybridization. (PMID: 10343101) Rankin J. … Lindsay S. (Cytogenet. Cell Genet. 1999) 2 3
  3. Novel missense mutation in WNT6 in 100 couples with unexplained recurrent miscarriage. (PMID: 25750203) Zhang Y. … Chen Z.J. (Hum. Reprod. 2015) 3
  4. WNT6 is a novel target gene of caveolin-1 promoting chemoresistance to epirubicin in human gastric cancer cells. (PMID: 22370641) Yuan G. … Burgermeister E. (Oncogene 2013) 3
  5. Polymorphisms in WNT6 and WNT10A and colorectal adenoma risk. (PMID: 21547848) Galbraith R.L. … Ulrich C.M. (Nutr Cancer 2011) 3

Products for WNT6 Gene

  • Addgene plasmids for WNT6
  • Addgene plasmids for WNT6

Sources for WNT6 Gene

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