Aliases for WNT6 Gene
Aliases for WNT6 Gene
External Ids for WNT6 Gene
- HGNC: 12785
- Entrez Gene: 7475
- Ensembl: ENSG00000115596
- OMIM: 604663
- UniProtKB: Q9Y6F9
Previous GeneCards Identifiers for WNT6 Gene
- GC02P217740
- GC02P218445
- GC02P219688
- GC02P219927
- GC02P219548
- GC02P219432
- GC02P219724
- GC02P211579
Summaries for WNT6 Gene
-
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level. [provided by RefSeq, Jul 2008]
GeneCards Summary for WNT6 Gene
WNT6 (Wnt Family Member 6) is a Protein Coding gene. Diseases associated with WNT6 include Gastric Cancer and Colorectal Cancer. Among its related pathways are DNA Damage Response (only ATM dependent) and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include receptor binding and frizzled binding. An important paralog of this gene is WNT1.
UniProtKB/Swiss-Prot for WNT6 Gene
-
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT6 Gene
Genomics for WNT6 Gene
GeneHancer (GH) Regulatory Elements for WNT6 Gene
- Top Transcription factor binding sites by QIAGEN in the WNT6 gene promoter:
Regulatory Element Products
Genomic Locations for WNT6 Gene
- chr2:218,859,821-218,874,233
- (GRCh38/hg38)
- Size:
- 14,413 bases
- Orientation:
- Plus strand
- chr2:219,724,544-219,738,955
- (GRCh37/hg19)
Genomic View for WNT6 Gene
- Cytogenetic band:
-
- 2q35 by Ensembl
- 2q35 by Entrez Gene
- 2q35 by HGNC


RefSeq DNA sequence for WNT6 Gene
Proteins for WNT6 Gene
-
Protein details for WNT6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y6F9-WNT6_HUMAN
- Recommended name:
- Protein Wnt-6
- Protein Accession:
- Q9Y6F9
- Q9H1J6
- Q9H238
Protein attributes for WNT6 Gene
- Size:
- 365 amino acids
- Molecular mass:
- 39721 Da
- Quaternary structure:
-
- Interacts with PORCN.
Protein Expression for WNT6 Gene
Post-translational modifications for WNT6 Gene
- Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
- Glycosylation at isoforms=86 and isoforms=311
Other Protein References for WNT6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for WNT6 (Wnt-6)
-
Custom Antibody ServicesOriGene Antibodies for WNT6
- Novus Biologicals Antibodies for WNT6
-
Abcam antibodies for WNT6
- Invitrogen Antibodies for WNT6
- antibodies-online: Search results for 74 available WNT6 Antibodies ranked by validation data
- Compare Top WNT6 Antibodies
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Recommended
- 19 WB Antibodies (anti-mouse)
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- 43 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 10 IHC (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 14 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- GeneTex WNT6 antibody for WNT6
Protein Products
-
OriGene Purified Proteins for WNT6
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-
Abcam proteins for WNT6
Assay Products
No data available for DME Specific Peptides for WNT6 Gene
Domains & Families for WNT6 Gene
Gene Families for WNT6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for WNT6 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for WNT6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y6F9- Family:
-
- Belongs to the Wnt family.
Function for WNT6 Gene
Molecular function for WNT6 Gene
- GENATLAS Biochemistry:
- wingless-type MMTV integration site 6,Drosophila wingless (wg) segment polarity gene homolog,expressed in ectoderm,somites,limb and mammary gland in mice,involved in short-range signaling during embryonic patterning
- UniProtKB/Swiss-Prot Function:
- Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway.
LifeMap Function Summary for WNT6 Gene
- Surface Ectoderm
- Brain
- Paraxial Mesoderm
Phenotypes From GWAS Catalog for WNT6 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | receptor binding | IEA | -- |
GO:0005109 | frizzled binding | IBA | -- |
Phenotypes for WNT6 Gene
- MGI mutant phenotypes for WNT6:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for WNT6:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for WNT6 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for WNT6
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- Overview of 90 available WNT6 gene related products
- Applied Biological Materials CRISPR for WNT6
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Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for WNT6
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miRNA for WNT6 Gene
- miRTarBase miRNAs that target WNT6
miRNA Products
- Search ViGene Biosciences for WNT6
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for WNT6
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- genomics-online: shRNA clones - Search results for 90 available WNT6 gene related products
- Overview of 90 available WNT6 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for WNT6 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for WNT6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for WNT6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for WNT6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for WNT6
-
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-
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-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WNT6 Gene
Localization for WNT6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for WNT6 Gene
- Secreted, extracellular space, extracellular matrix.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005578 | proteinaceous extracellular matrix | IEA | -- |
GO:0005615 | extracellular space | IBA | -- |
GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
GO:0005796 | Golgi lumen | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for WNT6 Gene
Pathways & Interactions for WNT6 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Gastric cancer |
.62
.62
|
|
2 | Transcription Androgen Receptor nuclear signaling |
.31
|
|
3 | Wnt Signaling Pathway and Pluripotency | ||
4 | Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling | ||
5 | mTOR signaling pathway (KEGG) |
Pathways by source for WNT6 Gene
2 Sino Biological pathways for WNT6 Gene
2 GeneTex pathways for WNT6 Gene
4 BioSystems pathways for WNT6 Gene
6 Reactome pathways for WNT6 Gene
13 KEGG pathways for WNT6 Gene
2 GeneGo (Thomson Reuters) pathways for WNT6 Gene
2 R&D Systems pathways for WNT6 Gene
1 Tocris pathway for WNT6 Gene
7 Qiagen pathways for WNT6 Gene
Interacting Proteins for WNT6 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001658 | branching involved in ureteric bud morphogenesis | IEA | -- |
GO:0007275 | multicellular organism development | IEA | -- |
GO:0009798 | axis specification | IEA | -- |
GO:0010628 | positive regulation of gene expression | IMP,IEA | 20113781 |
GO:0016055 | Wnt signaling pathway | TAS,IBA | -- |
Transcripts for WNT6 Gene
mRNA/cDNA for WNT6 Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (28) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for WNT6 Gene
CRISPR Products
-
OriGene CRISPR knockouts for WNT6
- genomics-online: gRNA clones - Search results for 90 available WNT6 gene related products
- Overview of 90 available WNT6 gene related products
- Applied Biological Materials CRISPR for WNT6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for WNT6
- GenScript: Design CRISPR guide RNA sequences for WNT6
miRNA Products
- Search ViGene Biosciences for WNT6
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for WNT6
- Browse OriGene Inhibitory RNA Products For WNT6
- genomics-online: shRNA clones - Search results for 90 available WNT6 gene related products
- Overview of 90 available WNT6 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for WNT6 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for WNT6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for WNT6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for WNT6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for WNT6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Tooth (Integumentary System)
- Dental Placode Cells Dental Placode
- Primary Enamel Knot Cells Enamel Knot
- Inner Enamel Epithelial Cells Dental Enamel
- Outer Enamel Epithelial Cells Dental Enamel
- Dental Enamel
-
Epithelial Cells
- Dental Placode Cells Dental Placode
- Inner Enamel Epithelial Cells Dental Enamel
- Outer Enamel Epithelial Cells Dental Enamel
- Primary Hair Placode Cells Hair Follicle
- Intermediate Keratinocytes Embryonic Epidermis
-
Kidney (Urinary System)
- Ureteric Bud Tip Cells Ureteric Bud
- Ureteric Bud
-
Hair (Integumentary System)
- Primary Hair Placode Cells Hair Follicle
- Basal Keratinocytes Embryonic Epidermis
-
Epidermis (Integumentary System)
- Intermediate Keratinocytes Embryonic Epidermis
- Basal Keratinocytes Embryonic Epidermis
-
Limb (Muscoskeletal System)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Ectoderm (Gastrulation Derivatives)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Peripheral Nervous System (Nervous System)
- Immature Schwann Cells Peripheral Nerve Domain
-
Hypoblast (Extraembryonic Tissues)
- Hypoblast Cells Hypoblast
- Gut Tube (Gastrointestinal Tract)
- Dermis (Integumentary System)
-
Heart (Cardiovascular System)
mRNA differential expression in normal tissues according to GTEx for WNT6 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WNT6 Gene
NURSA nuclear receptor signaling pathways regulating expression of WNT6 Gene:
WNT6SOURCE GeneReport for Unigene cluster for WNT6 Gene:
Hs.29764mRNA Expression by UniProt/SwissProt for WNT6 Gene:
Q9Y6F9-WNT6_HUMANPrimer Products
-
OriGene qPCR primer pairs and template standards for WNT6
-
OriGene qPCR primer pairs for WNT6
- genomics-online: primer clones - Search results for 90 available WNT6 gene related products
- Overview of 90 available WNT6 gene related products
No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WNT6 Gene
Orthologs for WNT6 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | WNT6 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | WNT6 34 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | WNT6 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | WNT6 33 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | WNT6 34 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Wnt6 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Wnt6 33 |
|
||
chicken (Gallus gallus) |
Aves | WNT6 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | WNT6 34 |
|
OneToOne | |
zebrafish (Danio rerio) |
Actinopterygii | wnt6b 33 34 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP009733 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | Wnt6 35 33 34 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | cwn-1 34 |
|
OneToMany | |
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany |
- Species where no ortholog for WNT6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for WNT6 Gene
Paralogs for WNT6 Gene
(18) SIMAP similar genes for WNT6 Gene using alignment to 2 proteins:
Variants for WNT6 Gene
SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs786205888 | likely-benign, Exstrophy of the bladder | 218,871,753(+) | G/A | coding_sequence_variant, synonymous_variant | |
rs1000805740 | -- | 218,870,565(+) | G/T | intron_variant | |
rs1000900154 | -- | 218,861,142(+) | G/C | intron_variant | |
rs1000925958 | -- | 218,861,510(+) | T/C | intron_variant | |
rs1000939744 | -- | 218,870,300(+) | A/G | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv7296n54 | CNV | loss | 21841781 |
nsv1072496 | CNV | deletion | 25765185 |
nsv834542 | CNV | gain | 17160897 |
nsv954838 | CNV | deletion | 24416366 |
Additional Variant Information for WNT6 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT6 Gene
Disorders for WNT6 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
gastric cancer |
|
|
colorectal cancer |
|
|
Additional Disease Information for WNT6
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for WNT6 Gene
Publications for WNT6 Gene
- WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells. (PMID: 11350055) Kirikoshi H … Katoh M (Biochemical and biophysical research communications 2001) 2 3 4 22 58
- Partial cloning and assignment of WNT6 to human chromosome band 2q35 by in situ hybridization. (PMID: 10343101) Rankin J … Lindsay S (Cytogenetics and cell genetics 1999) 2 3 4 58
- WNT6 is a novel target gene of caveolin-1 promoting chemoresistance to epirubicin in human gastric cancer cells. (PMID: 22370641) Yuan G … Burgermeister E (Oncogene 2013) 3 4 58
- Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 44 58
- Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations. (PMID: 16953426) Beaty TH … Scott AF (Human genetics 2006) 3 44 58
Products for WNT6 Gene
- R&D Systems Antibodies for WNT6 (Wnt-6)
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- Invitrogen Antibodies for WNT6
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- VectorBuilder custom plasmid, inducible vectors for WNT6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for WNT6
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 74 available WNT6 Antibodies ranked by validation data
- Compare Top WNT6 Antibodies
- Recommended
- 19 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 43 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 10 IHC (p) Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 14 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Search results for 8 available WNT6 Elisa Kits ranked by validation data
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- GeneTex WNT6 antibody for WNT6
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- ViGene Biosciences adenoviral particle packaged cDNA for WNT6 gene
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- Horizon Cell Lines for WNT6
- genomics-online: cdna clones - Search results for 90 available WNT6 gene related products
- Overview of 90 available WNT6 gene related products
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Sources for WNT6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
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