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WNT6 Gene

protein-coding   GIFtS: 63
GCID: GC02P219724

Wingless-Type MMTV Integration Site Family, Member 6

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Wingless-Type MMTV Integration Site Family, Member 61 2
Protein Wnt-62

External Ids:    HGNC: 127851   Entrez Gene: 74752   Ensembl: ENSG000001155967   OMIM: 6046635   UniProtKB: Q9Y6F93   

Export aliases for WNT6 gene to outside databases

Previous GC identifers: GC02P217740 GC02P218445 GC02P219688 GC02P219927 GC02P219548 GC02P219432 GC02P211579


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WNT6 Gene:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These
proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell
fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in
cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell
line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered
in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the
amino acid level. (provided by RefSeq, Jul 2008)

GeneCards Summary for WNT6 Gene:
WNT6 (wingless-type MMTV integration site family, member 6) is a protein-coding gene. Diseases associated with WNT6 include cervical cancer, and cervicitis. GO annotations related to this gene include frizzled binding. An important paralog of this gene is WNT5B.

UniProtKB/Swiss-Prot: WNT6_HUMAN, Q9Y6F9
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental
protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to
signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to
DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the WNT6 gene promoter:
         MyoD   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWNT6 promoter sequence
   Search Chromatin IP Primers for WNT6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WNT6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

WNT6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT6 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P219724:  view genomic region     (about GC identifiers)

Start:
219,724,544 bp from pter      End:
219,738,955 bp from pter
Size:
14,412 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: WNT6_HUMAN, Q9Y6F9 (See protein sequence)
Recommended Name: Protein Wnt-6 precursor  
Size: 365 amino acids; 39721 Da
Subunit: Interacts with PORCN (By similarity)
Secondary accessions: Q9H1J6 Q9H238

Explore the universe of human proteins at neXtProt for WNT6: NX_Q9Y6F9

Explore proteomics data for WNT6 at MOPED

Post-translational modifications: 

  • Palmitoylation at Ser-228 is required for efficient binding to frizzled receptors. It is also required for
    subsequent palmitoylation at Cys-76. Palmitoylation is necessary for proper trafficking to cell surface (By
    similarity)1
  • Glycosylation2 at Asn86, Asn311

  • See WNT6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006513.1  
    ENSEMBL proteins: 
     ENSP00000233948  
    Reactome Protein details: Q9Y6F9

    WNT6 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for WNT6
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    Novus Biologicals WNT6 Protein
    Novus Biologicals WNT6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WNT6

    WNT6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    WNT6 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for WNT6
    Cloud-Clone Corp. CLIAs for WNT6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WNT: Wingless-type MMTV integration sites

    3 InterPro protein domains:
     IPR009143 Wnt6
     IPR005817 Wnt
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry Q9Y6F9

    ProtoNet protein and cluster: Q9Y6F9

    1 Blocks protein domain: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WNT6_HUMAN, Q9Y6F9
    Similarity: Belongs to the Wnt family


    WNT6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WNT6_HUMAN, Q9Y6F9
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental
    protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to
    signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to
    DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway

         Genatlas biochemistry entry for WNT6:
    wingless-type MMTV integration site 6,Drosophila wingless (wg) segment polarity gene homolog,expressed in
    ectoderm,somites,limb and mammary gland in mice,involved in short-range signaling during embryonic patterning

         Summary: 
    During embryonic development, WNT6 as signaling molecule is secreted from the following cells:
                
    Surface Ectoderm: Surface Ectoderm Cells (Surface Ectoderm)

    It affects the following cells:
    Brain: Meningeal Progenitor Cells (Anterior Meninges)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005109frizzled binding IBA--
         
    WNT6 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for WNT6:
     Cell cycle / mitosis defect 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Wnt6):
     cellular  embryogenesis  endocrine/exocrine gland  reproductive system 

    WNT6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Wnt6tm1Akis for WNT6

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WNT6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for WNT6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WNT6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WNT6

    miRNA
    Products:
        
    miRTarBase miRNAs that target WNT6:
    hsa-mir-9-5p (MIRT021434)

    Block miRNA regulation of human, mouse, rat WNT6 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate WNT6:
    hsa-miR-525-5p hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidWNT6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for WNT6
    Predesigned siRNA for gene silencing in human, mouse, rat WNT6

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for WNT6

    Clone
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    OriGene clones in human, mouse for WNT6 (see all 6)
    OriGene ORF clones in mouse, rat for WNT6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WNT6 (NM_006522)
    Sino Biological Human cDNA Clone for WNT6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WNT6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT6

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for WNT6
    Browse ESI BIO Cell Lines and PureStem Progenitors for WNT6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WNT6_HUMAN, Q9Y6F9: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane3
    golgi apparatus2

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IBA--
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005796Golgi lumen TAS--

    WNT6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WNT6 About   (see all 20)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Wnt Pathway
    Wnt Pathway0.56
    WNT ligand biogenesis and trafficking0.56
    2Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathways0.40
    3Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway0.55
    DNA damage response (only ATM dependent)0.32
    Wnt Signaling Pathway and Pluripotency0.55
    4Basal cell carcinoma
    Basal cell carcinoma0.43
    Melanogenesis0.32
    Hedgehog signaling pathway0.43
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for WNT6
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for WNT6 (see all 7)
        GSK3 Signaling
    Presenilin-Mediated Signaling
    Colorectal Cancer Metastasis
    Human Embryonic Stem Cell Pluripotency
    Nanog in Mammalian ESC Pluripotency

    1 Tocris Bioscience Pathway for WNT6
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT6
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    3 BioSystems Pathways for WNT6
        Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    DNA damage response (only ATM dependent)

    2 Sino Biological Pathways for WNT6
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    2 Reactome Pathways for WNT6
        WNT ligand biogenesis and trafficking
    Class B/2 (Secretin family receptors)


    Selected Kegg Pathways  (Kegg details for WNT6) (see all 8):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection


    WNT6 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT6: 
              Notch Signaling Targets in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for WNT6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WNT6 (Q9Y6F93 ENSP000002339484) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PORCNQ9H2373, ENSP000003223044I2D: score=4 STRING: ENSP00000322304
    CER1ENSP000003702974STRING: ENSP00000370297
    FZD1ENSP000002879344STRING: ENSP00000287934
    FZD10ENSP000002290304STRING: ENSP00000229030
    FZD2ENSP000003239014STRING: ENSP00000323901
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001658branching involved in ureteric bud morphogenesis IEA--
    GO:0007267cell-cell signaling ----
    GO:0007275multicellular organismal development ----
    GO:0009798axis specification IEA--
    GO:0010628positive regulation of gene expression IMP--

    WNT6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WNT6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for WNT6 gene: 
    NM_006522.3  

    Unigene Cluster for WNT6:

    Wingless-type MMTV integration site family, member 6
    Hs.29764  [show with all ESTs]
    Unigene Representative Sequence: AY009401
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000233948(uc002vjc.1) ENST00000486233
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat WNT6 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate WNT6:
    hsa-miR-525-5p hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidWNT6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for WNT6
    Predesigned siRNA for gene silencing in human, mouse, rat WNT6
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WNT6 (NM_006522)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WNT6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT6
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for WNT6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WNT6
      QuantiTect SYBR Green Assays in human, mouse, rat WNT6
      QuantiFast Probe-based Assays in human, mouse, rat WNT6

    Additional mRNA sequence: 

    AB059570.1 AK075522.1 AY009401.1 BC004329.1 BT007456.1 

    3 DOTS entries:

    DT.112442  DT.91749172  DT.92013055 

    Selected AceView cDNA sequences (see all 28):

    AI218134 R78502 BU727755 BC004329 BF568080 BM720290 BM849242 AK075522 
    BM763339 BE392594 AY009401 BM687468 BT007456 NM_006522 AB059570 BF568920 
    BE744521 BF058854 BE410061 CD673352 BE382983 AA745754 AW128858 BF057511 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WNT6 expression in normal human tissues (normalized intensities)      WNT6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCACCAACG
    WNT6 Expression
    About this image


    WNT6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Tooth (Integumentary System)    fully expand to see all 6 entries
             Dental Placode Cells Dental Placode
             Dental Papilla
     
     Epithelial Cells
             Intermediate Keratinocytes Embryonic Epidermis
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Ureteric Bud Tip Cells Ureteric Bud
             Ureteric Bud
     
     Epidermis (Integumentary System)    fully expand to see all 2 entries
             Intermediate Keratinocytes Embryonic Epidermis
     
     Hair
             Primary Hair Placode Cells Hair Follicle
    WNT6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WNT6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.29764

    UniProtKB/Swiss-Prot: WNT6_HUMAN, Q9Y6F9
    Tissue specificity: Expressed in gastric cancer cell lines and gastric cancer tissues (at protein level). Detected
    in the apical gland region of the gastric foveolar epithelium (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT6: 
              Notch Signaling Targets in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for WNT6
    OriGene qSTAR qPCR primer pairs in human, mouse for WNT6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WNT6
    QuantiTect SYBR Green Assays in human, mouse, rat WNT6
    QuantiFast Probe-based Assays in human, mouse, rat WNT6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WNT6 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wnt61 , 5 wingless-related MMTV integration site 61, 5 87.57(n)1
    97.98(a)1
      1 (38.54 cM)5
    224201  NM_009526.31  NP_033552.21 
     747718925 
    chicken
    (Gallus gallus)
    Aves WNT61 wingless-type MMTV integration site family, member more 74.9(n)
    74.69(a)
      395235  NM_001007594.2  NP_001007595.1 
    lizard
    (Anolis carolinensis)
    Reptilia WNT66
    wingless-type MMTV integration site family, member...
    75(a)
    1 ↔ 1
    AAWZ02035345(13351-46878)
    zebrafish
    (Danio rerio)
    Actinopterygii wnt6b1 wingless-type MMTV integration site family, member more 68.06(n)
    73.13(a)
      561831  XM_003199189.2  XP_003199237.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Wnt61 , 3 frizzled-2 receptor signaling pathway
    signal transducer3
    Wnt oncogene analog 61
    49(a)3
    58.39(n)1
    49.06(a)1
      27F33
    340101  NM_001273259.11  NP_001260188.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cwn-16
    Protein CWN-1, isoform b (cwn-1) mRNA, complete cd...
    33(a)
    1 → many
    II(130983-133592) WBGene00000857


    ENSEMBL Gene Tree for WNT6 (if available)
    TreeFam Gene Tree for WNT6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WNT6 gene
    WNT5B2  WNT162  WNT5A2  WNT112  WNT22  WNT2B2  WNT3A2  WNT12  
    WNT42  WNT7A2  WNT7B2  WNT32  
    18 SIMAP similar genes for WNT6 using alignment to 2 protein entries:     WNT6_HUMAN (see all proteins):
    WNT4    WNT2B    WNT2    WNT7B    WNT5A    WNT3
    WNT9B    WNT5B    WNT1    WNT11    WNT7A    WNT3A
    WNT10B    WNT8B    WNT8A    WNT10A    WNT9A    WNT16

    WNT6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for WNT6 (see all 245)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs6908771,2
    C,F,A,H--219722664(+) ACCTGC/TAGCCT 1 -- us2k128Minor allele frequency- T:0.21NA EA NS WA CSA 2379
    rs1902304971,2
    C--219722736(+) AAACTC/GGGTAT 1 -- us2k10--------
    rs1488298241,2
    --219722802(+) TGGCAC/TTGCCC 1 -- us2k10--------
    rs1818825351,2
    --219722809(+) GCCCCA/GTAGAA 1 -- us2k10--------
    rs1469223471,2
    --219723107(+) TCATTC/TCTTCC 1 -- us2k10--------
    rs779781591,2
    F--219723268(+) GAAGCG/AACCTC 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1151202551,2
    C,F--219723379(+) AGGACA/GGCTTT 1 -- us2k11Minor allele frequency- G:0.14WA 118
    rs98080111,2
    C,F,H--219723431(+) TCCCAC/TACCAC 1 -- us2k1 tfbs36Minor allele frequency- T:0.05NS NA WA 906
    rs1853202261,2
    --219723447(+) CCTTGA/GCACCC 1 -- us2k10--------
    rs1378919221,2
    C--219723698(+) CTCTTA/GGACAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for WNT6 (219724544 - 219738955 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for WNT6:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv4436n71CNV Loss21882294
    nsv875864CNV Loss21882294
    nsv875867CNV Loss21882294
    nsv834542CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WNT6
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604663    OMIM disorders: --

    10 diseases for WNT6:    About MalaCards
    cervical cancer    cervicitis    colorectal cancer    ectodermal dysplasia
    labyrinthitis    basal cell carcinoma    meningitis    adenoma
    malaria    neuronitis


    WNT6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): WNT6
    Human Genome Epidemiology (HuGE) Navigator: WNT6 (2 documents)

    Export disorders for WNT6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WNT6 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with WNT6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. WNT10A and WNT6, clustered in human chromosome 2q35 region with head- to-tail manner, are strongly co-expressed in SW480 cells. (PubMed id 11350055)1, 2, 3, 9 Kirikoshi H.... Katoh M. (Biochem. Biophys. Res. Commun. 2001)
    2. Partial cloning and assignment of WNT6 to human chromosome band 2q35 by in situ hybridization. (PubMed id 10343101)1, 2, 3 Rankin J.... Lindsay S. (Cytogenet. Cell Genet. 1999)
    3. WNT6 is a novel target gene of caveolin-1 promoting chemoresistance to epirubicin in human gastric cancer cells. (PubMed id 22370641)1, 2 Yuan G....Burgermeister E. (Oncogene 2013)
    4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    5. Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations. (PubMed id 16953426)1, 4 Beaty T.H....Scott A.F. (Hum. Genet. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Polymorphisms in WNT6 and WNT10A and colorectal adenoma risk. (PubMed id 21547848)1 Galbraith R.L....Ulrich C.M. (Nutr Cancer 2011)
    8. Effect of Wnt6 on human dental papilla cells in vitro. (PubMed id 20113781)1 Wang C....Ye L. (J Endod 2010)
    9. Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: the odonto-onycho-dermal dysplasia. (PubMed id 17847007)1 Adaimy L.... Megarbane A. (Am. J. Hum. Genet. 2007)
    10. Expression patterns of Wnt genes during development of an anterior part of the chicken eye. (PubMed id 16258938)1 Fokina V.M. and Frolova E.I. (Dev. Dyn. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7475 HGNC: 12785 AceView: WNT6 Ensembl:ENSG00000115596 euGenes: HUgn7475
    ECgene: WNT6 Kegg: 7475 H-InvDB: WNT6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WNT6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WNT6 gene:
    Search GeneIP for patents involving WNT6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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