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Aliases for WNT5B Gene

Aliases for WNT5B Gene

  • Wnt Family Member 5B 2 3 5
  • Wingless-Type MMTV Integration Site Family, Member 5B 2

External Ids for WNT5B Gene

Previous GeneCards Identifiers for WNT5B Gene

  • GC12P001595
  • GC12P001596
  • GC12P001726
  • GC12P001639

Summaries for WNT5B Gene

Entrez Gene Summary for WNT5B Gene

  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT5B Gene

WNT5B (Wnt Family Member 5B) is a Protein Coding gene. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-independent Wnt/Ca2+ Signaling and Other Non-canonical Wnt Signaling Pathways and Transcription Androgen Receptor nuclear signaling. GO annotations related to this gene include receptor binding and frizzled binding. An important paralog of this gene is WNT5A.

UniProtKB/Swiss-Prot for WNT5B Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).

Gene Wiki entry for WNT5B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT5B Gene

Genomics for WNT5B Gene

Regulatory Elements for WNT5B Gene

Enhancers for WNT5B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G001589 1.7 FANTOM5 ENCODE dbSUPER 11.8 +63.5 63519 7.3 HDGF PKNOX1 ARNT AGO1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 WNT5B PIR54397 GC12M001593 FBXL14
GH12G001608 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +79.5 79534 2.7 FOXA2 ETV1 ZNF175 CEBPG ZBTB40 RARA ZNF366 SCRT2 TRIM24 ZNF548 WNT5B ENSG00000250132 ERC1 RAD52 ADIPOR2 FBXL14 MIR3649
GH12G001604 1.7 Ensembl ENCODE dbSUPER 10.9 +75.9 75899 2.8 HDGF MLX ARNT WRNIP1 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B YY1 WNT5B ENSG00000250132 ERC1 RAD52 FBXL14 MIR3649
GH12G001574 1.5 Ensembl ENCODE dbSUPER 12 +46.4 46370 3.3 FEZF1 ZNF2 TCF12 ZNF121 ZNF766 GLIS2 TSHZ1 ZNF488 MBD2 ZNF610 WNT5B ENSG00000249028 GC12M001593 PIR54620 PIR54397
GH12G001472 1.5 FANTOM5 Ensembl ENCODE 11.5 -55.3 -55269 4.4 SIN3A ZNF2 ZNF121 GATA2 ZNF143 FOS DEK ZNF263 REST TBX21 WNT5B ENSG00000249028 GC12M001458 GC12P001488
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WNT5B on UCSC Golden Path with GeneCards custom track

Promoters for WNT5B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000047679 809 1801 LEF1 SUZ12 BACH1 UBTF ZIC2 ZFHX2 GLIS2 POLR2A ZBTB20 EZH2

Transcription factor binding sites by QIAGEN in the WNT5B gene promoter:

Genomic Location for WNT5B Gene

Chromosome:
12
Start:
1,529,891 bp from pter
End:
1,647,243 bp from pter
Size:
117,353 bases
Orientation:
Plus strand

Genomic View for WNT5B Gene

Genes around WNT5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNT5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNT5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT5B Gene

Proteins for WNT5B Gene

  • Protein details for WNT5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1J7-WNT5B_HUMAN
    Recommended name:
    Protein Wnt-5b
    Protein Accession:
    Q9H1J7
    Secondary Accessions:
    • A8K315
    • D3DUP9
    • Q96S49
    • Q9BV04

    Protein attributes for WNT5B Gene

    Size:
    359 amino acids
    Molecular mass:
    40323 Da
    Quaternary structure:
    • Interacts with PORCN.

neXtProt entry for WNT5B Gene

Post-translational modifications for WNT5B Gene

  • Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at Asn93, isoforms=99, posLast=291291, and Asn305
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT5B Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for WNT5B (WNT5B)
  • Santa Cruz Biotechnology (SCBT) Antibodies for WNT5B

No data available for DME Specific Peptides for WNT5B Gene

Domains & Families for WNT5B Gene

Gene Families for WNT5B Gene

Protein Domains for WNT5B Gene

Suggested Antigen Peptide Sequences for WNT5B Gene

Graphical View of Domain Structure for InterPro Entry

Q9H1J7

UniProtKB/Swiss-Prot:

WNT5B_HUMAN :
  • Belongs to the Wnt family.
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT5B: view

Function for WNT5B Gene

Molecular function for WNT5B Gene

UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).

LifeMap Function Summary for WNT5B Gene

Gene Ontology (GO) - Molecular Function for WNT5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA,IPI 19486338
GO:0005109 frizzled binding IBA --
genes like me logo Genes that share ontologies with WNT5B: view
genes like me logo Genes that share phenotypes with WNT5B: view

Animal Models for WNT5B Gene

MGI Knock Outs for WNT5B:

Animal Model Products

  • Taconic Biosciences Mouse Models for WNT5B

CRISPR Products

miRNA for WNT5B Gene

miRTarBase miRNAs that target WNT5B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WNT5B Gene

Localization for WNT5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT5B Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WNT5B gene
Compartment Confidence
extracellular 5
plasma membrane 4
endoplasmic reticulum 4
golgi apparatus 4
nucleus 1

Gene Ontology (GO) - Cellular Components for WNT5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space NAS 15135146
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005796 Golgi lumen TAS --
genes like me logo Genes that share ontologies with WNT5B: view

Pathways & Interactions for WNT5B Gene

genes like me logo Genes that share pathways with WNT5B: view

SIGNOR curated interactions for WNT5B Gene

Activates:

Gene Ontology (GO) - Biological Process for WNT5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002062 chondrocyte differentiation IEP 15135146
GO:0007275 multicellular organism development IEA --
GO:0016055 Wnt signaling pathway IEA,TAS --
GO:0030182 neuron differentiation IBA,ISS --
GO:0030335 positive regulation of cell migration IDA 19486338
genes like me logo Genes that share ontologies with WNT5B: view

Drugs & Compounds for WNT5B Gene

(2) Drugs for WNT5B Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 1856
Platinum compounds Pharma 0
genes like me logo Genes that share compounds with WNT5B: view

Transcripts for WNT5B Gene

Unigene Clusters for WNT5B Gene

Wingless-type MMTV integration site family, member 5B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WNT5B Gene

No ASD Table

Relevant External Links for WNT5B Gene

GeneLoc Exon Structure for
WNT5B
ECgene alternative splicing isoforms for
WNT5B

Expression for WNT5B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WNT5B Gene

mRNA differential expression in normal tissues according to GTEx for WNT5B Gene

This gene is overexpressed in Esophagus - Muscularis (x4.9).

Protein differential expression in normal tissues from HIPED for WNT5B Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (68.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WNT5B Gene



Protein tissue co-expression partners for WNT5B Gene

NURSA nuclear receptor signaling pathways regulating expression of WNT5B Gene:

WNT5B

SOURCE GeneReport for Unigene cluster for WNT5B Gene:

Hs.306051

Evidence on tissue expression from TISSUES for WNT5B Gene

  • Muscle(4.3)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with WNT5B: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WNT5B Gene

Orthologs for WNT5B Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT5B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WNT5B 34 35
  • 99.07 (n)
dog
(Canis familiaris)
Mammalia WNT5B 34 35
  • 91.43 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WNT5B 35
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WNT5B 34 35
  • 87.79 (n)
mouse
(Mus musculus)
Mammalia Wnt5b 34 16 35
  • 87.74 (n)
rat
(Rattus norvegicus)
Mammalia Wnt5b 34
  • 87.19 (n)
oppossum
(Monodelphis domestica)
Mammalia WNT5B 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves WNT5B 34 35
  • 85.2 (n)
lizard
(Anolis carolinensis)
Reptilia WNT5B 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wnt5b 34
  • 79.38 (n)
African clawed frog
(Xenopus laevis)
Amphibia wnt-2-prov 34
zebrafish
(Danio rerio)
Actinopterygii wnt5b 34 35
  • 76.77 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010290 34
  • 54.41 (n)
fruit fly
(Drosophila melanogaster)
Insecta Wnt5 36
  • 51 (a)
Wnt2 36
  • 43 (a)
Wnt6 36
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea cwn-2 36 34 35
  • 49.7 (n)
egl-20 36
  • 35 (a)
mom-2 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4951 35
  • 50 (a)
OneToMany
Species where no ortholog for WNT5B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT5B Gene

ENSEMBL:
Gene Tree for WNT5B (if available)
TreeFam:
Gene Tree for WNT5B (if available)

Paralogs for WNT5B Gene

Paralogs for WNT5B Gene

(17) SIMAP similar genes for WNT5B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with WNT5B: view

Variants for WNT5B Gene

Sequence variations from dbSNP and Humsavar for WNT5B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000028294 -- 1,618,684(+) CTTCC(A/G)GTGGA intron-variant
rs1000212873 -- 1,638,512(+) TTTTT(G/T)ATGAT intron-variant
rs1000247121 -- 1,638,935(+) AGACA(C/T)TTCTG intron-variant
rs1000371117 -- 1,621,624(+) AGCTC(A/C)CTGCA intron-variant
rs1000669682 -- 1,628,587(+) CTCCC(C/T)TGGTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for WNT5B Gene

Variant ID Type Subtype PubMed ID
dgv257n67 CNV gain 20364138
esv2540814 CNV insertion 19546169
esv3628288 CNV loss 21293372
nsv513345 CNV insertion 21212237
nsv523570 CNV loss 19592680
nsv527641 CNV loss 19592680
nsv556994 CNV loss 21841781
nsv556995 CNV loss 21841781
nsv832304 CNV gain 17160897

Variation tolerance for WNT5B Gene

Residual Variation Intolerance Score: 23.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WNT5B Gene

Human Gene Mutation Database (HGMD)
WNT5B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WNT5B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT5B Gene

Disorders for WNT5B Gene

Relevant External Links for WNT5B

Genetic Association Database (GAD)
WNT5B
Human Genome Epidemiology (HuGE) Navigator
WNT5B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WNT5B

No disorders were found for WNT5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WNT5B Gene

Publications for WNT5B Gene

  1. Molecular cloning and characterization of human WNT5B on chromosome 12p13.3 region. (PMID: 11445850) Saitoh T. … Katoh M. (Int. J. Oncol. 2001) 2 3 4 64
  2. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 64
  3. Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma. (PMID: 19486338) Morioka K. … Matsuda K. (Cancer Sci. 2009) 3 22 64
  4. The effect of WNT5B IVS3C>G on the susceptibility to type 2 diabetes in UK Caucasian subjects. (PMID: 18555673) Salpea K.D. … Humphries S.E. (Nutr Metab Cardiovasc Dis 2009) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for WNT5B Gene

Sources for WNT5B Gene

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