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WNT5B Gene

protein-coding   GIFtS: 67
GCID: GC12P001639

Wingless-Type MMTV Integration Site Family, Member 5B

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Wingless-Type MMTV Integration Site Family, Member 5B1 2
Protein Wnt-5b2
WNT-5B Protein2

External Ids:    HGNC: 162651   Entrez Gene: 810292   Ensembl: ENSG000001111867   OMIM: 6063615   UniProtKB: Q9H1J73   

Export aliases for WNT5B gene to outside databases

Previous GC identifers: GC12P001595 GC12P001596 GC12P001726


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WNT5B Gene:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These
proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell
fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein
which shows 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively.
Alternative splicing of this gene generates 2 transcript variants. (provided by RefSeq, Jul 2008)

GeneCards Summary for WNT5B Gene:
WNT5B (wingless-type MMTV integration site family, member 5B) is a protein-coding gene. GO annotations related to this gene include frizzled binding and receptor binding. An important paralog of this gene is WNT16.

UniProtKB/Swiss-Prot: WNT5B_HUMAN, Q9H1J7
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental
protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to
signal over only few cell diameters (By similarity)

Gene Wiki entry for WNT5B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_009759.17  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WNT5B gene promoter:
         MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): WNT5B promoter sequence
   Search Chromatin IP Primers for WNT5B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WNT5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.3   Ensembl cytogenetic band:  12p13.33   HGNC cytogenetic band: 12p13.3

WNT5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT5B gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P001639:  view genomic region     (about GC identifiers)

Start:
1,639,057 bp from pter      End:
1,756,409 bp from pter
Size:
117,353 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: WNT5B_HUMAN, Q9H1J7 (See protein sequence)
Recommended Name: Protein Wnt-5b precursor  
Size: 359 amino acids; 40323 Da
Subunit: Interacts with PORCN (By similarity)
Secondary accessions: A8K315 D3DUP9 Q96S49 Q9BV04

Explore the universe of human proteins at neXtProt for WNT5B: NX_Q9H1J7

Explore proteomics data for WNT5B at MOPED

Post-translational modifications: 

  • Palmitoylation at Ser-223 is required for efficient binding to frizzled receptors. It is also required for
    subsequent palmitoylation at Cys-83. Palmitoylation is necessary for proper trafficking to cell surface (By
    similarity)1
  • Glycosylation2 at Asn93, Asn99, Asn291, Asn305
  • Modification sites at PhosphoSitePlus

  • See WNT5B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_110402.2  NP_116031.1  

    ENSEMBL proteins: 
     ENSP00000438414   ENSP00000445395   ENSP00000439312   ENSP00000308887   ENSP00000380379  
     ENSP00000442348   ENSP00000440600  
    Reactome Protein details: Q9H1J7

    WNT5B Human Recombinant Protein Products:

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    Novus Biologicals WNT5B Lysates
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    Cloud-Clone Corp. Proteins for WNT5B

     
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    antibodies-online proteins for WNT5B (9 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WNT: Wingless-type MMTV integration sites

    3 InterPro protein domains:
     IPR026537 Wnt5b
     IPR005817 Wnt
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry Q9H1J7

    ProtoNet protein and cluster: Q9H1J7

    1 Blocks protein domain: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WNT5B_HUMAN, Q9H1J7
    Similarity: Belongs to the Wnt family


    Find genes that share domains with WNT5B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WNT5B_HUMAN, Q9H1J7
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental
    protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to
    signal over only few cell diameters (By similarity)

         Summary: 

    During embryonic development, WNT5B as signaling molecule is secreted from the following cells:
                
    Neural Tube: Floor Plate Cells (Spinal Floor Plate)

    It affects the following cells:       fully expand
    Adipose: Subcutaneous White Preadipocytes (Facial Subcutaneous White Adipose), Subcutaneous White Preadipocytes (Subcutaneous White Adipose)      fully expand to see all 3 cells
    Neural Tube: Somatic Motor Neurons (Motor Neural Progenitor Domain)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI19486338
    GO:0005109frizzled binding IBA--
         
    Find genes that share ontologies with WNT5B           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for WNT5B:
     Decreased viability of wild-ty 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Wnt5b):
     limbs/digits/tail  mortality/aging  nervous system 

    Find genes that share phenotypes with WNT5B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Wnt5btm1Tmj for WNT5B

       genOway: Develop your customized and physiologically relevant rodent model for WNT5B

    miRNA
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    miRTarBase miRNAs that target WNT5B:
    hsa-mir-185-5p (MIRT045371), hsa-mir-124-3p (MIRT022886)

    Block miRNA regulation of human, mouse, rat WNT5B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WNT5B (see all 19):
    hsa-miR-300 hsa-miR-15a hsa-miR-374a hsa-miR-766 hsa-miR-410 hsa-miR-424 hsa-miR-195 hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmidWNT5B 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WNT5B_HUMAN, Q9H1J7: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane3
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space NAS15135146
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005796Golgi lumen TAS--

    Find genes that share ontologies with WNT5B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WNT5B About   (see all 20)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt Pathway
    Wnt Pathway0.56
    WNT ligand biogenesis and trafficking0.56
    2Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathways0.40
    3Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway0.55
    DNA damage response (only ATM dependent)0.32
    Wnt Signaling Pathway and Pluripotency0.55
    4Basal cell carcinoma
    Basal cell carcinoma0.43
    Melanogenesis0.32
    Hedgehog signaling pathway0.43
    5beta-catenin independent WNT signaling
    beta-catenin independent WNT signaling0.79
    Signaling by Wnt0.79


    Find genes that share SuperPaths with WNT5B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for WNT5B
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for WNT5B (see all 7)
        GSK3 Signaling
    Presenilin-Mediated Signaling
    Colorectal Cancer Metastasis
    Human Embryonic Stem Cell Pluripotency
    Nanog in Mammalian ESC Pluripotency

    1 Cell Signaling Technology (CST) Pathway for WNT5B
        Wnt / Hedgehog / Notch

    1 Tocris Bioscience Pathway for WNT5B
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT5B
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    4 BioSystems Pathways for WNT5B
        Wnt Signaling Pathway
    Adipogenesis
    DNA damage response (only ATM dependent)
    Wnt Signaling Pathway and Pluripotency


    2 Reactome Pathways for WNT5B
        PCP/CE pathway
    WNT ligand biogenesis and trafficking


    Selected Kegg Pathways  (Kegg details for WNT5B) (see all 8):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT5B: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat
              Adipogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for WNT5B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WNT5B (Q9H1J72, 3 ENSP000003088874) via UniProtKB, MINT, STRING, and/or I2D (see all 98)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPBP2Q926242, 3, ENSP000000831824MINT-67310 I2D: score=5 STRING: ENSP00000083182
    PORCNQ9H2373, ENSP000003223044I2D: score=4 STRING: ENSP00000322304
    CER1ENSP000003702974STRING: ENSP00000370297
    FZD1ENSP000002879344STRING: ENSP00000287934
    FZD10ENSP000002290304STRING: ENSP00000229030
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002062chondrocyte differentiation IEP15135146
    GO:0007275multicellular organismal development ----
    GO:0016055Wnt signaling pathway IMP15135146
    GO:0030182neuron differentiation ISS--
    GO:0030335positive regulation of cell migration IDA19486338

    Find genes that share ontologies with WNT5B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WNT5B

    1 PharmGKB related drug/compound annotation for WNT5B gene    About this table
    Drug/compound PharmGKB Annotation
    fluorouracilCA  



    Find genes that share compounds with WNT5B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WNT5B gene (2 alternative transcripts): 
    NM_030775.2  NM_032642.2  

    Unigene Cluster for WNT5B:

    Wingless-type MMTV integration site family, member 5B
    Hs.306051  [show with all ESTs]
    Unigene Representative Sequence: BC001749
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000539198 ENST00000545811 ENST00000537031 ENST00000538854 ENST00000310594(uc001qjj.3)
    ENST00000397196(uc009zdq.3 uc001qjk.3 uc001qjl.3) ENST00000543563
    ENST00000543071 ENST00000542408 ENST00000545747
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    Additional mRNA sequence: 

    AB060966.1 AB209228.1 AK290430.1 AK294096.1 AY009399.1 BC001749.1 

    9 DOTS entries:

    DT.111787  DT.91868774  DT.95266417  DT.121185343  DT.92011846  DT.121185304  DT.91763199  DT.95266419 
    DT.97814811 

    Selected AceView cDNA sequences (see all 141):

    AI686324 AI333193 AW592602 AI971048 NM_030775 AI090460 CA428994 BF589687 
    NM_032642 AI738405 CB854269 AI565228 CB140219 AI424438 AI201930 AA599839 
    AI139353 BF057365 BG420565 AI990255 BF056538 AI620526 BF056525 BC001749 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WNT5B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTGCGGGC
    WNT5B Expression
    About this image


    WNT5B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Mesencephalic Floor Plate
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord blood-derived hematopoietic stem cells
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Umbilical cord blood-derived hematopoietic stem cells
     
     Epithelial Cells
             Outer Root Sheath Cells Outer Root Sheath
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    WNT5B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WNT5B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.306051
        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT5B: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat
              Adipogenesis in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT5B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WNT5B gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wnt5b1 , 5 wingless-related MMTV integration site 5B1, 5 87.74(n)1
    94.15(a)1
      6 (56.86 cM)5
    224191  NM_001271757.11  NP_001258686.11 
     1194325315 
    chicken
    (Gallus gallus)
    Aves WNT5B1 wingless-type MMTV integration site family, member more 85.2(n)
    89.12(a)
      418154  NM_001037269.1  NP_001032346.1 
    lizard
    (Anolis carolinensis)
    Reptilia WNT5B6
    wingless-type MMTV integration site family, member...
    81(a)
    1 ↔ 1
    5(12649701-12776919)
    African clawed frog
    (Xenopus laevis)
    Amphibia wnt-2-prov2 C. elegans WNT family member precursor (40.4 kD) (wnt-2) 80.41(n)    X73510.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wnt5b1 wingless-type MMTV integration site family, member more 76.77(n)
    83.09(a)
      30105  NM_130937.1  NP_571012.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0102901 AgaP_AGAP010290 54.41(n)
    53.27(a)
      1279717  XM_319487.4  XP_319487.4 
    worm
    (Caenorhabditis elegans)
    Secernentea cwn-21 , 3 WNT-2 precursor3
    cwn-21
    45(a)
    (best of 3)3
    49.7(n)1
    47.92(a)1
      IV(10068050-10070141)3
    1778701  NM_069421.41  NP_501822.11 


    ENSEMBL Gene Tree for WNT5B (if available)
    TreeFam Gene Tree for WNT5B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WNT5B gene
    WNT162  WNT62  WNT5A2  WNT112  WNT22  WNT2B2  WNT3A2  WNT12  
    WNT42  WNT7A2  WNT7B2  WNT32  
    17 SIMAP similar genes for WNT5B using alignment to 5 protein entries:     WNT5B_HUMAN (see all proteins):
    WNT5A    WNT7B    WNT2B    WNT7A    WNT4    WNT3
    WNT3A    WNT8A    WNT8B    WNT11    WNT2    WNT1
    WNT6    WNT9B    WNT10B    WNT16    WNT9A

    Find genes that share paralogs with WNT5B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WNT5B (see all 841)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs760920791,2
    C,F--1724224(+) AATTTC/TGGACT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs714548331,2
    C,F--1724238(+) AACTAC/TGTGTC 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1147307741,2
    C,F--1724239(+) ACTACG/ATGTCA 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1445347931,2
    C--1724381(+) TGGAAC/TGACAT 1 -- us2k10--------
    rs1923098171,2
    --1724432(+) TATAAC/TGTATT 1 -- us2k10--------
    rs619122551,2
    C,F--1724433(+) ATAACG/ATATTG 1 -- us2k15Minor allele frequency- A:0.06NA WA EA 362
    rs1453955791,2
    --1724482(+) TCTACA/GAGATT 1 -- us2k10--------
    rs1487798141,2
    --1724635(+) TTTTCA/GTTTAC 1 -- us2k10--------
    rs1848392281,2
    C--1724712(+) TTGCAA/GAATGG 1 -- us2k10--------
    rs1423995081,2
    --1724752(+) TGGAAA/GTATAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for WNT5B (1639057 - 1756409 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for WNT5B (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv513345CNV Insertion21212237
    esv2540814CNV Insertion19546169
    nsv898587CNV Loss21882294
    nsv898591CNV Loss21882294
    nsv527641CNV Loss19592680
    nsv523570CNV Loss19592680
    dgv1340n71CNV Loss21882294
    nsv832304CNV Gain17160897
    nsv898586CNV Gain21882294
    dgv257n67CNV Gain20364138

    Human Gene Mutation Database (HGMD): WNT5B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WNT5B
    DNA2.0 Custom Variant and Variant Library Synthesis for WNT5B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606361    OMIM disorders: --


    Find genes that share disorders with WNT5B           About GenesLikeMe

    Genetic Association Database (GAD): WNT5B
    Human Genome Epidemiology (HuGE) Navigator: WNT5B (3 documents)

    Export disorders for WNT5B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WNT5B gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with WNT5B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of human WNT5B on chromosome 12p13.3 region. (PubMed id 11445850)1, 2, 3 Saitoh T. and Katoh M. (Int. J. Oncol. 2001)
    2. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    3. The effect of WNT5B IVS3C&gt;G on the susceptibility to type 2 diabetes in UK Caucasian subjects. (PubMed id 18555673)1, 4 Salpea K.D....Humphries S.E. (Nutr Metab Cardiovasc Dis 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma. (PubMed id 19486338)1, 9 Morioka K....Matsuda K. (Cancer Sci. 2009)
    6. Mesodermal progenitor cells (MPCs) differentiate into mesenchymal stromal cells (MSCs) by activation of Wnt5/calmodulin signalling pathway. (PubMed id 21980498)1 Fazzi R....Petrini M. (PLoS ONE 2011)
    7. [Role of TFAP2B and WntSB in adipose tissue]. (PubMed id 21766608)1 Ugi S....Maeda S. (Nippon Rinsho 2011)
    8. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    9. Variation in WNT genes expression in different subtypes of chronic lymphocytic leukemia. (PubMed id 19863181)1 Memarian A....Shokri F. (amp 2009)
    10. Wnt5b stimulates adipogenesis by activating PPARgamma, and inhibiting the beta-catenin dependent Wnt signaling pathway together with Wnt5a. (PubMed id 19577541)1 van Tienen F.H....Smeets H.J. (Biochem. Biophys. Res. Commun. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81029 HGNC: 16265 AceView: WNT5B Ensembl:ENSG00000111186 euGenes: HUgn81029
    ECgene: WNT5B Kegg: 81029 H-InvDB: WNT5B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WNT5B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT5B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WNT5B gene:
    Search GeneIP for patents involving WNT5B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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