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Aliases for WNT5B Gene

Aliases for WNT5B Gene

  • Wingless-Type MMTV Integration Site Family, Member 5B 2 3

External Ids for WNT5B Gene

Previous GeneCards Identifiers for WNT5B Gene

  • GC12P001595
  • GC12P001596
  • GC12P001726
  • GC12P001639

Summaries for WNT5B Gene

Entrez Gene Summary for WNT5B Gene

  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT5B Gene

WNT5B (Wingless-Type MMTV Integration Site Family, Member 5B) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include receptor binding and frizzled binding. An important paralog of this gene is WNT1.

UniProtKB/Swiss-Prot for WNT5B Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).

Gene Wiki entry for WNT5B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT5B Gene

Genomics for WNT5B Gene

Regulatory Elements for WNT5B Gene

Transcription factor binding sites by QIAGEN in the WNT5B gene promoter:

Genomic Location for WNT5B Gene

Start:
1,529,891 bp from pter
End:
1,647,243 bp from pter
Size:
117,353 bases
Orientation:
Plus strand

Genomic View for WNT5B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WNT5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT5B Gene

Proteins for WNT5B Gene

  • Protein details for WNT5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1J7-WNT5B_HUMAN
    Recommended name:
    Protein Wnt-5b
    Protein Accession:
    Q9H1J7
    Secondary Accessions:
    • A8K315
    • D3DUP9
    • Q96S49
    • Q9BV04

    Protein attributes for WNT5B Gene

    Size:
    359 amino acids
    Molecular mass:
    40323 Da
    Quaternary structure:
    • Interacts with PORCN.

neXtProt entry for WNT5B Gene

Proteomics data for WNT5B Gene at MOPED

Post-translational modifications for WNT5B Gene

  • Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at Asn93, Asn99, Asn291, and Asn305
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT5B Gene

No data available for DME Specific Peptides for WNT5B Gene

Domains for WNT5B Gene

Gene Families for WNT5B Gene

HGNC:
  • WNT :Wingless-type MMTV integration sites

Protein Domains for WNT5B Gene

Suggested Antigen Peptide Sequences for WNT5B Gene

Graphical View of Domain Structure for InterPro Entry

Q9H1J7

UniProtKB/Swiss-Prot:

WNT5B_HUMAN :
  • Q9H1J7
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT5B: view

Function for WNT5B Gene

Molecular function for WNT5B Gene

UniProtKB/Swiss-Prot Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).

LifeMap Function Summary for WNT5B Gene

Gene Ontology (GO) - Molecular Function for WNT5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 19486338
GO:0005109 frizzled binding IBA --
genes like me logo Genes that share ontologies with WNT5B: view
genes like me logo Genes that share phenotypes with WNT5B: view

Animal Models for WNT5B Gene

MGI Knock Outs for WNT5B:

miRNA for WNT5B Gene

miRTarBase miRNAs that target WNT5B

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for WNT5B Gene

Localization for WNT5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT5B Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WNT5B Gene COMPARTMENTS Subcellular localization image for WNT5B gene
Compartment Confidence
extracellular 5
plasma membrane 3
nucleus 1

Gene Ontology (GO) - Cellular Components for WNT5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space NAS 15135146
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005796 Golgi lumen TAS --
genes like me logo Genes that share ontologies with WNT5B: view

Pathways for WNT5B Gene

genes like me logo Genes that share pathways with WNT5B: view

Gene Ontology (GO) - Biological Process for WNT5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002062 chondrocyte differentiation IEP 15135146
GO:0007275 multicellular organismal development --
GO:0016055 Wnt signaling pathway IMP 15135146
GO:0030182 neuron differentiation ISS --
GO:0030335 positive regulation of cell migration IDA 19486338
genes like me logo Genes that share ontologies with WNT5B: view

Compounds for WNT5B Gene

(1) PharmGKB related drug/compound annotations for WNT5B Gene

Drug/compound Annotation
fluorouracil CA
genes like me logo Genes that share compounds with WNT5B: view

Transcripts for WNT5B Gene

Unigene Clusters for WNT5B Gene

Wingless-type MMTV integration site family, member 5B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WNT5B Gene

No ASD Table

Relevant External Links for WNT5B Gene

GeneLoc Exon Structure for
WNT5B
ECgene alternative splicing isoforms for
WNT5B

Expression for WNT5B Gene

mRNA expression in normal human tissues for WNT5B Gene

mRNA differential expression in normal tissues according to GTEx for WNT5B Gene

This gene is overexpressed in Esophagus - Muscularis (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WNT5B Gene

SOURCE GeneReport for Unigene cluster for WNT5B Gene Hs.306051

genes like me logo Genes that share expressions with WNT5B: view

No data available for mRNA Expression by UniProt/SwissProt for WNT5B Gene

Orthologs for WNT5B Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT5B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WNT5B 35
  • 99.07 (n)
  • 99.72 (a)
WNT5B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WNT5B 35
  • 87.79 (n)
  • 90.41 (a)
WNT5B 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WNT5B 35
  • 91.43 (n)
  • 92.77 (a)
WNT5B 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wnt5b 35
  • 87.74 (n)
  • 94.15 (a)
Wnt5b 16
Wnt5b 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WNT5B 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WNT5B 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wnt5b 35
  • 87.19 (n)
  • 94.15 (a)
chicken
(Gallus gallus)
Aves WNT5B 35
  • 85.2 (n)
  • 89.12 (a)
WNT5B 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WNT5B 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia wnt-2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia wnt5b 35
  • 79.38 (n)
  • 86.42 (a)
zebrafish
(Danio rerio)
Actinopterygii wnt5b 35
  • 76.77 (n)
  • 83.09 (a)
wnt5b 36
  • 76 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010290 35
  • 54.41 (n)
  • 53.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta Wnt5 37
  • 51 (a)
Wnt6 37
  • 43 (a)
Wnt2 37
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea cwn-2 35
  • 49.7 (n)
  • 47.92 (a)
cwn-2 36
  • 44 (a)
OneToMany
egl-20 37
  • 35 (a)
mom-2 37
  • 31 (a)
cwn-2 37
  • 45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4951 36
  • 50 (a)
OneToMany
Species with no ortholog for WNT5B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT5B Gene

ENSEMBL:
Gene Tree for WNT5B (if available)
TreeFam:
Gene Tree for WNT5B (if available)

Paralogs for WNT5B Gene

Paralogs for WNT5B Gene

Selected SIMAP similar genes for WNT5B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with WNT5B: view

Variants for WNT5B Gene

Sequence variations from dbSNP and Humsavar for WNT5B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs735890 -- 1,645,258(+) TCTAG(A/G)GATGG intron-variant
rs735891 -- 1,645,340(+) CTCAA(A/G)TGATC intron-variant
rs735892 -- 1,644,964(+) GGGGG(C/T)GTCTG intron-variant
rs886848 -- 1,630,159(+) CCCGG(A/G)GAGCC intron-variant, missense, reference
rs1003939 -- 1,647,512(+) CTCAC(A/G)TTTAC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for WNT5B Gene

Variant ID Type Subtype PubMed ID
nsv898584 CNV Gain 21882294
dgv257n67 CNV Gain 20364138
nsv898586 CNV Gain 21882294
nsv832304 CNV Gain 17160897
esv2540814 CNV Insertion 19546169
nsv513345 CNV Insertion 21212237
nsv898587 CNV Loss 21882294
dgv1340n71 CNV Loss 21882294
nsv898591 CNV Loss 21882294
nsv527641 CNV Loss 19592680
nsv523570 CNV Loss 19592680

Relevant External Links for WNT5B Gene

HapMap Linkage Disequilibrium report
WNT5B
Human Gene Mutation Database (HGMD)
WNT5B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT5B Gene

Disorders for WNT5B Gene

Relevant External Links for WNT5B

Genetic Association Database (GAD)
WNT5B
Human Genome Epidemiology (HuGE) Navigator
WNT5B
genes like me logo Genes that share disorders with WNT5B: view

No data available for UniProtKB/Swiss-Prot for WNT5B Gene

Publications for WNT5B Gene

  1. Molecular cloning and characterization of human WNT5B on chromosome 12p13.3 region. (PMID: 11445850) Saitoh T. … Katoh M. (Int. J. Oncol. 2001) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma. (PMID: 19486338) Morioka K. … Matsuda K. (Cancer Sci. 2009) 3 23
  4. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 48
  5. The effect of WNT5B IVS3C>G on the susceptibility to type 2 diabetes in UK Caucasian subjects. (PMID: 18555673) Salpea K.D. … Humphries S.E. (Nutr Metab Cardiovasc Dis 2009) 3 48

Products for WNT5B Gene

  • Addgene plasmids for WNT5B

Sources for WNT5B Gene

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