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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WNT5B Gene

protein-coding   GIFtS: 63
GCID: GC12P001639

wingless-type MMTV integration site family, member 5B
 Explore 15 diseases affiliated with
WNT5B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for WNT5B    

Aliases
for WNT5B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Wingless-Type MMTV Integration Site Family, Member 5B1 2
Protein Wnt-5b2
WNT-5B Protein2

External Ids:    HGNC: 162651   Entrez Gene: 810292   Ensembl: ENSG000001111867   OMIM: 6063615   UniProtKB: Q9H1J73   

Export aliases for WNT5B gene to outside databases

Previous GC identifers: GC12P001595 GC12P001596 GC12P001726


Summaries
for WNT5B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for WNT5B:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins
have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and
patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 94%
and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing
of this gene generates 2 transcript variants. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: WNT5B_HUMAN, Q9H1J7
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein.
May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over
only few cell diameters (By similarity)

Gene Wiki entry for WNT5B


Genomic Views
for WNT5B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009759.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WNT5B gene promoter:
         MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): WNT5B promoter sequence
   Search SABiosciences Chromatin IP Primers for WNT5B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WNT5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.3   Ensembl cytogenetic band:  12p13.33   HGNC cytogenetic band: 12p13.3

WNT5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT5B gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P001639:  view genomic region     (about GC identifiers)

Start:
 1,639,057 bp from pter      End:
 1,756,409 bp from pter
Size:
 117,353 bases      Orientation:
 plus strand

Proteins
for WNT5B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: WNT5B_HUMAN, Q9H1J7 (See protein sequence)
Recommended Name: Protein Wnt-5b precursor  
Size: 359 amino acids; 40323 Da
Subunit: Interacts with PORCN (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix
Secondary accessions: A8K315 D3DUP9 Q96S49 Q9BV04

Explore the universe of human proteins at neXtProt for WNT5B: NX_Q9H1J7

Post-translational modifications:

  • Palmitoylation at Ser-223 is required for efficient binding to frizzled receptors. It is also required for subsequent
    • palmitoylation at Cys-83. Palmitoylation is necessary for proper trafficking to cell surface (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H1J7

    • WNT5B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_110402.2  NP_116031.1  

    ENSEMBL proteins: 
     ENSP00000438414   ENSP00000445395   ENSP00000439312   ENSP00000308887   ENSP00000380379  
     ENSP00000442348   ENSP00000440600  

    Human Recombinant Protein Products: 
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    OriGene Custom Protein Services for WNT5B 
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    Novus Biologicals WNT5B Protein
    Novus Biologicals WNT5B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for WNT5B

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space NAS15135146
    GO:0005886plasma membrane IBA--
    GO:0009986cell surface IEA--
    GO:0031012extracellular matrix ----


    WNT5B for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for WNT5B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    WNT5B for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR026537 Wnt5b
     IPR005817 Wnt
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry Q9H1J7

    ProtoNet protein and cluster: Q9H1J7

    1 Blocks protein family: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WNT5B_HUMAN, Q9H1J7
    Similarity: Belongs to the Wnt family


    Function
    for WNT5B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: WNT5B_HUMAN, Q9H1J7
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein.
    May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over
    only few cell diameters (By similarity)

         Summary:  

    During embryonic development, WNT5B as signaling molecule
    affects the following cells: Subcutaneous White Preadipocytes in Cranial Subcutaneous White Adipose, Subcutaneous White Preadipocytes in Subcutaneous White Adipose (see all 3).

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WNT5B
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate WNT5B (see all 19):
    hsa-miR-300 hsa-miR-15a hsa-miR-374a hsa-miR-766 hsa-miR-410 hsa-miR-424 hsa-miR-195 hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmid: WNT5B 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WNT5B (see all 7)
    OriGene shRNA RFP: WNT5B
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WNT5B (see all 4)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): WNT5B (NM_030775)
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    Cell Line
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    Search LifeMap BioReagents cell lines for WNT5B

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT5B

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI19486338
    GO:0005110frizzled-2 binding IBA--


    WNT5B for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for WNT5B:
     Decreased viability of wild-ty 

    Animal Models:
         Mouse knock-out Wnt5btm1Tmj for WNT5B
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Wnt5b):
     limbs/digits/tail  mortality/aging  nervous system 

    WNT5B for phenotypes           About GeneDecksing


    Pathways & Interactions
    for WNT5B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Wnt Signaling Pathway
    		Wnt Signaling Pathway1.00
    		Wnt Signaling Pathway0.33
    		Wnt Signaling Pathway and Pluripotency0.55
    		Wnt signaling pathway0.30
    		DNA damage response (only ATM dependent)0.35
    2Basal cell carcinoma
    		Basal cell carcinoma1.00
    		Wnt Pathway0.37
    		Hedgehog signaling pathway0.41
    		Melanogenesis0.32
    3Translation_Non-genomic (rapid) action of Androgen Receptor
    		Translation_Non-genomic (rapid) action of Androgen Receptor1.00
    		Translation Non-genomic (rapid) action of Androgen Receptor0.99
    4Transcription_Androgen Receptor nuclear signaling
    		Transcription_Androgen Receptor nuclear signaling1.00
    		Transcription Androgen Receptor nuclear signaling0.99
    5Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency1.00
    		GSK3 Signaling0.61

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for WNT5B
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    1 R&D Systems Pathway for WNT5B
        Wnt Signaling Pathway

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for WNT5B (see all 7)
        GSK3 Signaling
    Presenilin-Mediated Signaling
    Colorectal Cancer Metastasis
    Human Embryonic Stem Cell Pluripotency
    Nanog in Mammalian ESC Pluripotency

    1 Cell Signaling Technology (CST) Pathway for WNT5B
        Wnt / Hedgehog / Notch

    1 Tocris Bioscience Pathway for WNT5B
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT5B
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    4 BioSystems Pathways for WNT5B 
        Wnt Signaling Pathway and Pluripotency
    Adipogenesis
    Wnt Signaling Pathway
    DNA damage response (only ATM dependent)


    5         Kegg Pathways  (Kegg details for WNT5B):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Melanogenesis
    Pathways in cancer
    Basal cell carcinoma


    WNT5B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WNT5B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/18 Interacting proteins for WNT5B (Q9H1J72, 3 ENSP000003088874) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPBP2Q926242, 3, ENSP000000831824MINT-67310 I2D: score=5 STRING: ENSP00000083182
    PORCNQ9H2373, ENSP000003223044I2D: score=4 STRING: ENSP00000322304
    CER1ENSP000003702974STRING: ENSP00000370297
    FZD1ENSP000002879344STRING: ENSP00000287934
    FZD10ENSP000002290304STRING: ENSP00000229030
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IBA--
    GO:0002062chondrocyte differentiation IEP15135146
    GO:0007223Wnt receptor signaling pathway, calcium modulating pathway IBA--
    GO:0007275multicellular organismal development ----
    GO:0009950dorsal/ventral axis specification IBA--


    WNT5B for ontologies           About GeneDecksing



    Drugs & Compounds
    for WNT5B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for WNT5B:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WNT5B
    Search CenterWatch for drugs/clinical trials and news about WNT5B 

    Transcripts
    for WNT5B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for WNT5B gene (2 alternative transcripts): 
    NM_030775.2  NM_032642.2  

    Unigene Cluster for WNT5B:

    Wingless-type MMTV integration site family, member 5B
    Hs.306051  [show with all ESTs]
    Unigene Representative Sequence: BC001749
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000539198 ENST00000545811 ENST00000537031 ENST00000538854 ENST00000310594(uc001qjj.3)
    ENST00000397196(uc009zdq.3 uc001qjk.3 uc001qjl.3) ENST00000543563
    ENST00000543071 ENST00000542408 ENST00000545747

    miRNA
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    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate WNT5B (see all 19):
    hsa-miR-300 hsa-miR-15a hsa-miR-374a hsa-miR-766 hsa-miR-410 hsa-miR-424 hsa-miR-195 hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmid: WNT5B 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WNT5B
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    Additional cDNA sequence: 

    AB060966.1 AB209228.1 AK290430.1 AK294096.1 AY009399.1 BC001749.1 

    9 DOTS entries:

    DT.111787  DT.91868774  DT.95266417  DT.121185343  DT.92011846  DT.121185304  DT.91763199  DT.95266419 
    DT.97814811 

    24/141 AceView cDNA sequences (see all 141):

    CB140219 BF222222 BF222673 AI686324 AI201930 AI493316 AA599839 AI123210 
    AW592602 AI990255 BU625742 AI972458 BF222304 AA599463 NM_030775 AI620526 
    BF589687 BF056538 AI738405 AI090460 BU608246 AI333193 NM_032642 BG420565 

    GeneLoc Exon Structure


    Expression
    for WNT5B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WNT5B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCTGCGGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    WNT5B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Head MesenchymeBranchial Arch 1Cranial Neural Crest CellsNeural Crest
    BrainCerebral CortexBrain
    EyeRetinaEye
    KidneyRenal VesicleKidney
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Sclerotome cells (Primary Cell)Bone, Cartilage, Somite

    See WNT5B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WNT5B

    SOURCE GeneReport for Unigene cluster: Hs.306051
        SABiosciences Expression via Pathway-Focused PCR Arrays including WNT5B: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat
              Adipogenesis in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for WNT5B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for WNT5B gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves WNT5B1 wingless-type MMTV integration site family, member more 84.18(n)
    87.29(a)    		   418154  NM_001037269.1  NP_001032346.1 
    lizard
    (Anolis carolinensis)    		 Reptilia WNT5B6
    		 --
    		 83(a)
    		 1 ↔ 1
    		 5(12751885-12775923)
    African clawed frog
    (Xenopus laevis)    		 Amphibia wnt-2-prov2 C. elegans WNT family member precursor (40.4 kD) (wnt-2) 80.41(n)    X73510.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wnt5b1 wingless-type MMTV integration site family, member more 75.71(n)
    81.36(a)    		   30105  NM_130937.1  NP_571012.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Wnt51 , 3 Wnt receptor signaling pathway signal
    transducer3
    Wnt oncogene analog 51    		 51(a)
    (best of 3)3
    60.77(n)1
    51.15(a)1    		   328381  NM_057576.41  NP_476924.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea cwn-21 , 3 WNT-2 precursor3
    Protein CWN-21    		 45(a)
    (best of 3)3
    49.65(n)1
    48.06(a)1    		   IV(10068050-10070141)3
    1778701  NM_069421.31  NP_501822.11 


    ENSEMBL Gene Tree for WNT5B (if available)
    TreeFam Gene Tree for WNT5B (if available) 

    Paralogs
    for WNT5B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WNT5B gene
    WNT162  WNT62  WNT5A2  WNT112  WNT22  WNT2B2  WNT3A2  WNT12  
    WNT10B2  WNT42  WNT7A2  WNT7B2  WNT10A2  WNT32  
    18 SIMAP similar genes for WNT5B using alignment to 5 protein entries:     WNT5B_HUMAN (see all proteins):
    WNT5A    WNT7B    WNT2B    WNT7A    WNT4    WNT3
    WNT3A    WNT8A    WNT8B    WNT2    WNT11    WNT1
    WNT6    WNT9B    WNT10B    WNT16    WNT9A    WNT10A

    WNT5B for paralogs           About GeneDecksing



    Genomic Variants
    for WNT5B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/692 NCBI SNPs in WNT5B are shown (see all 692)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs760920791,2
    		--1724224(+) AATTTC/TGGACT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs714548331,2
    		C,--1724238(+) AACTAC/TGTGTC 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1147307741,2
    		C,F,--1724239(+) ACTACG/ATGTCA 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1445347931,2
    		--1724381(+) TGGAAC/TGACAT 1 -- us2k10--------
    rs1923098171,2
    		--1724432(+) TATAAC/TGTATT 1 -- us2k10--------
    rs619122551,2
    		C,F,--1724433(+) ATAACG/ATATTG 1 -- us2k15Minor allele frequency- A:0.06NA WA EA 362
    rs1453955791,2
    		--1724482(+) TCTACA/GAGATT 1 -- us2k10--------
    rs1487798141,2
    		--1724635(+) TTTTCA/GTTTAC 1 -- us2k10--------
    rs1848392281,2
    		--1724712(+) TTGCAA/GAATGG 1 -- us2k10--------
    rs1423995081,2
    		--1724752(+) TGGAAA/GTATAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for WNT5B (1639057 - 1756409 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for WNT5B
         2 CNVs: 86141 4765
         1 Indel: 101403
    Human Gene Mutation Database (HGMD): WNT5B

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    Disorders / Diseases
    for WNT5B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    WNT5B for disorders           About GeneDecksing

    OMIM gene information: 606361    OMIM disorders: --

    15 diseases for WNT5B:    About MalaCards
    goldenhar syndrome    basal cell carcinoma    chronic lymphocytic leukemia    lymphocytic leukemia
    benign tumors    hermaphroditism    leiomyoma    hepatocellular carcinoma
    pharyngitis    colorectal cancer    leukemia    osteosarcoma
    carcinoma    melanoma    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: WNT5B (3 documents)

    Export disorders for WNT5B gene to outside databases

    Publications
    for WNT5B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WNT5B gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with WNT5B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of human WNT5B on chromosome 12p13.3 region. (PubMed id 11445850)1, 2, 3 Saitoh T. and Katoh M. (2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Orphan receptor tyrosine kinase ROR2 as a potential t herapeutic target for osteosarcoma. (PubMed id 19486338)1, 9 Morioka K....Matsuda K. (2009)
    4. Mesodermal progenitor cells (MPCs) differentiate into mesenchymal stromal cells (MSCs) by activation of Wnt5/calmodulin signalling p athway. (PubMed id 21980498)1 Fazzi R....Petrini M. (2011)
    5. [Role of TFAP2B and WntSB in adipose tissue]. (PubMed id 21766608)1 Ugi S....Maeda S. (2011)
    6. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1 Yerges L.M....Zmuda J.M. (2009)
    7. Variation in WNT genes expression in different subtyp es of chronic lymphocytic leukemia. (PubMed id 19863181)1 Memarian A....Shokri F. (2009)
    8. Wnt5b stimulates adipogenesis by activating PPARgamma , and inhibiting the beta-catenin dependent Wnt signaling pathway together with Wnt5a. (PubMed id 19577541)1 van Tienen F.H....Smeets H.J. (2009)
    9. The effect of WNT5B IVS3C>G on the susceptibility to type 2 diabetes in UK Caucasian subjects. (PubMed id 18555673)1 Salpea K.D....Humphries S.E. (2008)
    10. Expression patterns of Wnt genes during development of an anterior part of the chicken eye. (PubMed id 16258938)1 Fokina V.M. and Frolova E.I. (2006)

    External Searches for WNT5B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing WNT5B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81029 HGNC: 16265 AceView: WNT5B Ensembl:ENSG00000111186 euGenes: HUgn81029
    ECgene: WNT5B Kegg: 81029 H-InvDB: WNT5B

    Other Databases showing WNT5B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing WNT5B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WNT5B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT5B Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for WNT5B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for WNT5B gene:
    Search GeneIP for patents involving WNT5B

    GeneCards and IP:
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