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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WNT5A Gene

protein-coding   GIFtS: 68
GCID: GC03M055474

wingless-type MMTV integration site family, member 5A
 Explore 55 diseases affiliated with
WNT5A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for WNT5A    

Aliases
for WNT5A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Wingless-Type MMTV Integration Site Family, Member 5A1 2
HWNT5A1
Protein Wnt-5a2
WNT-5A Protein2

External Ids:    HGNC: 127841   Entrez Gene: 74742   Ensembl: ENSG000001142517   OMIM: 1649755   UniProtKB: P412213   

Export aliases for WNT5A gene to outside databases

Previous GC identifers: GC03M054370 GC03M054625 GC03M055356 GC03M055458 GC03M055457


Summaries
for WNT5A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for WNT5A:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins
have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and
patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical
and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the
tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during
embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal
dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. (provided by RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: WNT5A_HUMAN, P41221
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical
Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the
presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent
pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical
pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases
proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor.
Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior
axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes

Gene Wiki entry for WNT5A


Genomic Views
for WNT5A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WNT5A gene promoter:
         GATA-3   AP-1   ATF-2   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   Egr-4   COMP1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): WNT5A promoter sequence
   Search SABiosciences Chromatin IP Primers for WNT5A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WNT5A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21-p14   Ensembl cytogenetic band:  3p14.3   HGNC cytogenetic band: 3p21-p14

WNT5A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT5A gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M055474:  view genomic region     (about GC identifiers)

Start:
 55,499,743 bp from pter      End:
 55,523,973 bp from pter
Size:
 24,231 bases      Orientation:
 minus strand

Proteins
for WNT5A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: WNT5A_HUMAN, P41221 (See protein sequence)
Recommended Name: Protein Wnt-5a precursor  
Size: 380 amino acids; 42339 Da
Subunit: Homooligomer; disulfide-linked, leading to inactivation. Interacts with PORCN. Interacts with WLS (By
similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix
Secondary accessions: A8K4A4 Q6P278
Alternative splicing: 2 isoforms:  P41221-1   P41221-2   

Explore the universe of human proteins at neXtProt for WNT5A: NX_P41221

Post-translational modifications:

  • Palmitoylation is necessary for stimulation of cell migration, inhibition of the beta-catenin pathway and receptor
    • binding (By similarity)1
  • Glycosylation is necessary for secretion but not for activity (By similarity)1
  • Palmitoylation at Ser-244 is required for efficient binding to frizzled receptors. It is also required for subsequent
    • palmitoylation at Cys-104. Palmitoylation is necessary for proper trafficking to cell surface (By similarity)1
  • Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading
    • to inactivation of WNT5A (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P41221

    • WNT5A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243034.1  NP_003383.2  

    ENSEMBL proteins: 
     ENSP00000417310   ENSP00000420104   ENSP00000418184   ENSP00000264634  
    Reactome Protein details: P41221
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant WNT5A Protein
    R&D Systems Recombinant & Natural Proteins for WNT5A (Wnt-5a)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: WNT5A
    OriGene Protein Over-expression Lysate: WNT5A
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    Novus Biologicals WNT5A Proteins
    Novus Biologicals WNT5A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for WNT5A

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IDA--
    GO:0005624membrane fraction ----
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane IBA--


    WNT5A for ontologies           About GeneDecksing



    WNT5A Antibody Products: 
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    Novus Biologicals WNT5A Antibodies
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    Uscn Antibodies for WNT5A
    ThermoFisher Antibody for WNT5A

    Assay Products for WNT5A: 
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    GenScript Custom Assay Services for WNT5A
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for WNT5A

    Protein Domains /
    Families
    for WNT5A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    WNT5A for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR026538 Wnt5a
     IPR005817 Wnt
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry P41221

    ProtoNet protein and cluster: P41221

    1 Blocks protein family: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WNT5A_HUMAN, P41221
    Similarity: Belongs to the Wnt family


    Function
    for WNT5A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: WNT5A_HUMAN, P41221
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical
    Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the
    presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent
    pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical
    pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases
    proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor.
    Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior
    axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes

         Genatlas biochemistry entry for WNT5A:
    wingless-type MMTV integration site 5A,Drosophila wingless (wg) segment polarity gene homolog,expressed in developing
    face,ventral area of midbrain,limbs an in adult brain,lung,modulating cell fate and cell behavior during vertebrate
    development

    miRNA
    Products:            		miRTarBase miRNAs that target WNT5A:
    hsa-mir-30a (MIRT005162)

    OriGene 3'-UTR Clone: WNT5A
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WNT5A
    8/85 QIAGEN miScript miRNA Assays for microRNAs that regulate WNT5A (see all 85):
    hsa-miR-576-3p hsa-miR-323-3p hsa-miR-579 hsa-miR-520f hsa-miR-300 hsa-miR-218-1* hsa-miR-200a hsa-miR-3074-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WNT5A (see all 7)
    OriGene shRNA RFP: WNT5A
    OriGene siRNA: WNT5A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WNT5A

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for WNT5A

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WNT5A (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WNT5A
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: WNT5A (NM_003392)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WNT5A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT5A 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for WNT5A
    LifeMap BioReagents: cell line associated with WNT5A: PureStem Z11, Meso Progenitor

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT5A

    Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IMP19847889
    GO:0005102receptor binding ----
    GO:0005109frizzled binding IPI18174455
    GO:0005110frizzled-2 binding IBA--
    GO:0005115receptor tyrosine kinase-like orphan receptor binding IPI18287027


    WNT5A for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for WNT5A:
     Increased G1 DNA content  Synthetic lethal with imatinib 

    Animal Models:
         Mouse knock-out Wnt5atm1Amc for WNT5A
         15 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Wnt5a):
     cellular  craniofacial  digestive/alimentary  embryogenesis  growth/size 
     hearing/vestibular/ear  homeostasis/metabolism  limbs/digits/tail  liver/biliary system  mortality/aging 
     nervous system  renal/urinary system  reproductive system  respiratory system  skeleton 

    WNT5A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for WNT5A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Wnt Signaling Pathway
    		Wnt Signaling Pathway1.00
    		Wnt Signaling Pathway0.33
    		Wnt Signaling Pathway and Pluripotency0.55
    		Wnt signaling pathway0.30
    		DNA damage response (only ATM dependent)0.35
    		Wnt Signaling Pathway NetPath0.22
    2Basal cell carcinoma
    		Basal cell carcinoma1.00
    		Wnt Pathway0.37
    		Hedgehog signaling pathway0.41
    		Melanogenesis0.32
    3Translation_Non-genomic (rapid) action of Androgen Receptor
    		Translation_Non-genomic (rapid) action of Androgen Receptor1.00
    		Translation Non-genomic (rapid) action of Androgen Receptor0.99
    4Transcription_Androgen Receptor nuclear signaling
    		Transcription_Androgen Receptor nuclear signaling1.00
    		Transcription Androgen Receptor nuclear signaling0.99
    5Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency1.00
    		GSK3 Signaling0.61

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for WNT5A
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    1 R&D Systems Pathway for WNT5A
        Wnt Signaling Pathway

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for WNT5A (see all 8)
        GSK3 Signaling
    Molecular Mechanisms of Cancer
    Presenilin-Mediated Signaling
    Human Embryonic Stem Cell Pluripotency
    Colorectal Cancer Metastasis

    1 Cell Signaling Technology (CST) Pathway for WNT5A
        Wnt / Hedgehog / Notch

    1 Tocris Bioscience Pathway for WNT5A
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT5A
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    5/8 BioSystems Pathways for WNT5A (see all 8) 
        DNA damage response (only ATM dependent)
    MicroRNAs in cardiomyocyte hypertrophy
    Wnt Signaling Pathway and Pluripotency
    Wnt Signaling Pathway
    Wnt Signaling Pathway NetPath

    4        Reactome Pathways for WNT5A
        Signal Transduction
    Signaling by GPCR
    GPCR ligand binding
    Class B/2 (Secretin family receptors)


    5         Kegg Pathways  (Kegg details for WNT5A):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Melanogenesis
    Pathways in cancer
    Basal cell carcinoma


    WNT5A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WNT5A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/37 Interacting proteins for WNT5A (P412213 ENSP000002646344) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FZD1Q9UP383, ENSP000002879344I2D: score=3 STRING: ENSP00000287934
    FZD5Q134673, ENSP000003546074I2D: score=1 STRING: ENSP00000354607
    LRP6O755813, ENSP000002613494I2D: score=1 STRING: ENSP00000261349
    ROR2Q019743, ENSP000003648604I2D: score=2 STRING: ENSP00000364860
    PORCNQ9H2373, ENSP000003223044I2D: score=3 STRING: ENSP00000322304
    About this table

    Gene Ontology (GO): 5/143 biological process terms (GO ID links to tree view) (see all 143):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IDA--
    GO:0001667ameboidal cell migration IEA--
    GO:0001736establishment of planar polarity IEA--
    GO:0001756somitogenesis IBA--
    GO:0001837epithelial to mesenchymal transition IEP12841867


    WNT5A for ontologies           About GeneDecksing



    Drugs & Compounds
    for WNT5A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    WNT5A for compounds           About GeneDecksing

    EMD Millipore small molecules for WNT5A:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WNT5A
    5 Novoseek chemical compound relationships for WNT5A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycogen 33.3 6 10873564 (1), 18407462 (1), 17986005 (1), 12915680 (1) (see all 5)
    tyrosine 23.2 12 18615587 (3), 17986005 (2), 17463182 (1), 19561643 (1) (see all 8)
    retinoic acid 0.428 9 15592517 (3), 15925444 (1)
    calcium 0 8 17463182 (2), 18929644 (2), 14766423 (1), 19420254 (1) (see all 6)
    paraffin 0 1 14514922 (1)

    Search CenterWatch for drugs/clinical trials and news about WNT5A 

    Transcripts
    for WNT5A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for WNT5A gene (2 alternative transcripts): 
    NM_001256105.1  NM_003392.4  

    Unigene Cluster for WNT5A:

    Wingless-type MMTV integration site family, member 5A
    Hs.643085  [show with all ESTs]
    Unigene Representative Sequence: NM_003392
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000474267(uc003dhm.3 uc010hmw.3 uc003dhn.3 uc010hmx.3)
    ENST00000493406 ENST00000497027 ENST00000482079 ENST00000497817 ENST00000264634


    miRNA
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    8/85 QIAGEN miScript miRNA Assays for microRNAs that regulate WNT5A (see all 85):
    hsa-miR-576-3p hsa-miR-323-3p hsa-miR-579 hsa-miR-520f hsa-miR-300 hsa-miR-218-1* hsa-miR-200a hsa-miR-3074-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene shRNA RFP: WNT5A
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT5A 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WNT5A
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WNT5A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WNT5A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WNT5A

    Additional cDNA sequence: 

    AK021503.1 AK090582.1 AK290375.1 AK290869.1 BC064694.1 BC074783.2 EF028086.1 

    6 DOTS entries:

    DT.95294716  DT.440946  DT.120885032  DT.100744120  DT.102824816  DT.70101564 

    24/129 AceView cDNA sequences (see all 129):

    AW238894 AW069504 AI123013 BX105276 AI819089 BF430942 CA429390 AW055279 
    BX503521 AI394540 AA932802 AA903835 AL700501 AI339491 AI683487 BM746350 
    AI634753 BE045609 NM_003392 BE671209 CB992663 AI750799 BF589063 AL079945 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for WNT5A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7
    SP1:              -     -     -           -     -                           
    SP2:              -     -     -                                             
    SP3:                                                                        
    SP4:                                                                        
    SP5:                    -     -                                             


    ECgene alternative splicing isoforms for WNT5A

    Expression
    for WNT5A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WNT5A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCATTCAGAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    WNT5A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainSubstantia Nigra pars CompactaAdult Dopaminergic NeuronsDopaminergic neurons
    BrainSubstantia Nigra pars CompactaEmbryonic Dopaminergic NeuronsDopaminergic neurons
    BrainVentral Tegmental AreaAdult Dopaminergic NeuronsDopaminergic neurons
    BrainVentral Tegmental AreaEmbryonic Dopaminergic NeuronsDopaminergic neurons
    Head MesenchymeBranchial Arch 1Cranial Neural Crest CellsNeural Crest
    KidneyMetanephric MesenchymeMetanephric Mesenchyme CellsKidney
    LungLung BudDistal Lung Progenitor CellsLung
    EyeInner Nuclear LayernGnG Amacrine CellsAmacrine, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 7 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)
    Embryoid bodies (Generation and expan...)
    Primitive gut tube-like cells (A scalable, suspensi...)
    Primordial germ cell-like cells (Reconstitution of mo...)

    See WNT5A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WNT5A

    SOURCE GeneReport for Unigene cluster: Hs.643085

    UniProtKB/Swiss-Prot: WNT5A_HUMAN, P41221
    Tissue specificity: Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and
    anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in
    stromal cells (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Arrays including WNT5A (see all 10): 
              Wound Healing in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Adipogenesis in human mouse rat
              Estrogen Receptor Signaling in human mouse rat
              Notch Signaling Targets in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for WNT5A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for WNT5A gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves WNT5A1 wingless-type MMTV integration site family, member more 84.74(n)
    90(a)    		   395703  NM_204887.1  NP_990218.1 
    lizard
    (Anolis carolinensis)    		 Reptilia WNT5A6
    		 --
    		 88(a)
    		 1 ↔ 1
    		 2(161755890-161769143)
    African clawed frog
    (Xenopus laevis)    		 Amphibia wnt5a-B2 wingless-type MMTV integration site family, member more 78.67(n)    L19716.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wnt5a2 wingless-type MMTV integration site family, member more 81.32(n)   30105  NM_130937.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Wnt53 Wnt receptor signaling pathway signal
    transducer    		 52(a)
    (best of 3)    		     --
    worm
    (Caenorhabditis elegans)    		 Secernentea cwn-23 WNT-2 precursor 43(a)
    (best of 3)    		   IV(10068050-10070141)   --


    ENSEMBL Gene Tree for WNT5A (if available)
    TreeFam Gene Tree for WNT5A (if available) 

    Paralogs
    for WNT5A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WNT5A gene
    WNT5B2  WNT162  WNT62  WNT112  WNT22  WNT2B2  WNT3A2  WNT12  
    WNT10B2  WNT42  WNT7A2  WNT7B2  WNT10A2  WNT32  
    18 SIMAP similar genes for WNT5A using alignment to 4 protein entries:     WNT5A_HUMAN (see all proteins):
    WNT5B    WNT7B    WNT2B    WNT4    WNT2    WNT7A
    WNT3    WNT3A    WNT8A    WNT8B    WNT16    WNT1
    WNT11    WNT6    WNT9A    WNT9B    WNT10B    WNT10A

    WNT5A for paralogs           About GeneDecksing



    Genomic Variants
    for WNT5A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/348 NCBI SNPs in WNT5A are shown (see all 348)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs5903861,2
    		C,F,O,H,--55499407(-) AAAACG/AATGTT 2 -- ds500121Minor allele frequency- A:0.13MN NS EA NA WA 2302
    rs5895571,2
    		C,F,--55499579(-) CATTTT/GTCTTT 2 -- ds500111Minor allele frequency- G:0.12EA NA MN WA 663
    rs1892330101,2
    		--55499651(+) TGTACA/GTGTGT 2 -- ds50010--------
    rs124972541,2
    		C,F,H,--55499664(+) TTCTGA/GATACC 2 -- ds500130Minor allele frequency- N:0.00EA NA NS CSA WA 2962
    rs10478981,2
    		C,F,A,H,--55499781(-) TTCATG/ATCTTG 2 -- ut3115Minor allele frequency- A:0.47MN NS EA NA CSA WA 970
    rs1816804181,2
    		--55499941(+) ACATTA/TAAAAA 2 -- ut310--------
    rs1402551521,2
    		--55500264(+) TTAGAA/CCTGTG 2 -- ut310--------
    rs1875904551,2
    		--55500274(+) GCCTTC/TGTGCC 2 -- ut310--------
    rs1920307831,2
    		--55500375(+) CTAACA/GATCTC 2 -- ut310--------
    rs108659941,2
    		C,F,A,H,--55500408(+) TCTTAT/ATCAGA 2 -- ut3123Minor allele frequency- A:0.47NS EA NA CSA WA 2339

    HapMap Linkage Disequilibrium report for WNT5A (55499743 - 55523973 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for WNT5A
         1 CNV: 3430
    Human Gene Mutation Database (HGMD): WNT5A

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for WNT5A

    Disorders / Diseases
    for WNT5A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    WNT5A for disorders           About GeneDecksing

    OMIM gene information: 164975    OMIM disorders: --

    UniProtKB/Swiss-Prot: WNT5A_HUMAN, P41221
  • Defects in WNT5A are the cause of Robinow syndrome autosomal dominant (DRS) [MIM:180700]. A disease
    • characterized by short-limb dwarfism, costovertebral segmentation defects and abnormalities of the head, face and
    external genitalia. The clinical signs are generally milder in dominant cases

    20/55 diseases for WNT5A (see all 55):    About MalaCards
    mayer-rokitansky-kuster-hauser syndrome    rokitansky-kuster-hauser syndrome    robinow syndrome    zimmermann-laband syndrome
    estrogen-receptor negative breast cancer    cleft lip/palate    familial adenomatous polyposis    laband syndrome
    cleft lip    b-cell lymphomas    merkel cell carcinoma    cleft palate
    myeloid leukemia    breast cancer susceptibility    basal cell carcinoma    chronic myeloid leukemia
    acute myeloid leukemia    polyposis    epithelial ovarian cancer    breast cancer

    10/14 Novoseek disease relationships for WNT5A gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 38.3 51 18927296 (4), 15701836 (3), 19237581 (3), 16880514 (3) (see all 18)
    invasive cancer 28.7 2 19901340 (1), 9815976 (1)
    metastasis 27 13 18927296 (2), 19901340 (2), 16880514 (2), 19244247 (1) (see all 8)
    tumors 25.8 38 11809689 (4), 16314637 (4), 15735754 (3), 15701836 (2) (see all 18)
    cancer 23.2 19 19603030 (4), 9367869 (2), 9716023 (2), 18294932 (1) (see all 11)
    melanoma 22.6 17 19901340 (4), 19470740 (3), 14514922 (2), 17992121 (1) (see all 9)
    mammary tumor 21.5 2 12471617 (1), 19519951 (1)
    familial adenomatous polyposis 10.4 1 17463182 (1)
    primary tumor 7.6 1 15701836 (1)
    carcinoma squamous cell 3.42 6 16314637 (3), 19467340 (1), 19956879 (1), 12841867 (1)

    Human Genome Epidemiology (HuGE) Navigator: WNT5A (10 documents)

    Export disorders for WNT5A gene to outside databases

    Publications
    for WNT5A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WNT5A gene, integrated from 9 sources (see all 253):
    (articles sorted by number of sources associating them with WNT5A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21. (PubMed id 8288227)1, 2, 3, 9 Clark C.C.... Iozzo R.V. (1993)
    2. Wnt-5a has tumor suppressor activity in thyroid carcinoma. (PubMed id 15735754)1, 2, 9 Kremenevskaja N....Brabant G. (2005)
    3. WNT5A mutations in patients with autosomal dominant R obinow syndrome. (PubMed id 19918918)1, 2 Person A.D....Lohr J.L. (2010)
    4. The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition. (PubMed id 17426020)1, 2 Dissanayake S.K.... Weeraratna A.T. (2007)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Wnt5a is expressed in murine and human atherosclerotic lesions. (PubMed id 18456733)1, 9 Christman M.A....Malgor R. (2008)
    7. Wnt5a regulates distinct signalling pathways by bindi ng to Frizzled2. (PubMed id 19910923)1, 9 Sato A....Kikuchi A. (2010)
    8. Wnt-5a mRNA translation is suppressed by the Elav-like protein HuR in human breast epithelial cells. (PubMed id 16914445)1, 9 Leandersson K....Andersson T. (2006)
    9. Laminin gamma2 mediates Wnt5a-induced invasion of gas tric cancer cells. (PubMed id 19582886)1, 9 Yamamoto H....Kikuchi A. (2009)
    10. Construction of human Wnt-5a sense gene and RNAi euka ryotic expression vector. (PubMed id 19467340)1, 9 Huang Y....Yang H. (2009)

    External Searches for WNT5A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing WNT5A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7474 HGNC: 12784 AceView: WNT5A Ensembl:ENSG00000114251 euGenes: HUgn7474
    ECgene: WNT5A Kegg: 7474 H-InvDB: WNT5A

    Other Databases showing WNT5A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing WNT5A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WNT5A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT5A Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for WNT5A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for WNT5A gene:
    Search GeneIP for patents involving WNT5A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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     WNT5A Proteins, Antibodies, CLIAs, and ELISAs
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