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Aliases for WNT5A Gene

Aliases for WNT5A Gene

  • Wingless-Type MMTV Integration Site Family, Member 5A 2 3
  • WNT-5A Protein 2 3
  • Protein Wnt-5a 3
  • HWNT5A 3

External Ids for WNT5A Gene

Summaries for WNT5A Gene

Entrez Gene Summary for WNT5A Gene

  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for WNT5A Gene

WNT5A (Wingless-Type MMTV Integration Site Family, Member 5A) is a Protein Coding gene. Diseases associated with WNT5A include robinow syndrome, autosomal dominant and wnt5a-related robinow syndrome, autosomal dominant. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and cytokine activity. An important paralog of this gene is WNT1.

UniProtKB/Swiss-Prot for WNT5A Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.

Gene Wiki entry for WNT5A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT5A Gene

Genomics for WNT5A Gene

Genomic Location for WNT5A Gene

Start:
55,465,715 bp from pter
End:
55,490,539 bp from pter
Size:
24,825 bases
Orientation:
Minus strand

Genomic View for WNT5A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WNT5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT5A Gene

Regulatory Elements for WNT5A Gene

Proteins for WNT5A Gene

  • Protein details for WNT5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41221-WNT5A_HUMAN
    Recommended name:
    Protein Wnt-5a
    Protein Accession:
    P41221
    Secondary Accessions:
    • A8K4A4
    • Q6P278

    Protein attributes for WNT5A Gene

    Size:
    380 amino acids
    Molecular mass:
    42339 Da
    Quaternary structure:
    • Homooligomer; disulfide-linked, leading to inactivation. Interacts with PORCN. Interacts with WLS (By similarity).

    Alternative splice isoforms for WNT5A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WNT5A Gene

Proteomics data for WNT5A Gene at MOPED

Post-translational modifications for WNT5A Gene

  • Glycosylation is necessary for secretion but not for activity.
  • Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
  • Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT5A.
  • Glycosylation at Asn114, Asn120, Asn312, and Asn326

Other Protein References for WNT5A Gene

No data available for DME Specific Peptides for WNT5A Gene

Domains for WNT5A Gene

Gene Families for WNT5A Gene

HGNC:
  • ENDOLIG :Endogenous ligands
  • WNT :Wingless-type MMTV integration sites

Protein Domains for WNT5A Gene

UniProtKB/Swiss-Prot:

WNT5A_HUMAN
Family:
  • Belongs to the Wnt family.:
    • P41221
genes like me logo Genes that share domains with WNT5A: view

Function for WNT5A Gene

Molecular function for WNT5A Gene

GENATLAS Biochemistry: wingless-type MMTV integration site 5A,Drosophila wingless (wg) segment polarity gene homolog,expressed in developing face,ventral area of midbrain,limbs an in adult brain,lung,modulating cell fate and cell behavior during vertebrate development
UniProtKB/Swiss-Prot Function: Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.

LifeMap Function Summary for WNT5A Gene

During embryonic development, WNT5A as signaling molecule is secreted from the following cells
It affects the following cells:

Gene Ontology (GO) - Molecular Function for WNT5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity IMP 19847889
GO:0005102 receptor binding --
GO:0005109 frizzled binding IPI 18174455
GO:0005110 frizzled-2 binding IEA --
GO:0005115 receptor tyrosine kinase-like orphan receptor binding IPI 18287027
genes like me logo Genes that share ontologies with WNT5A: view
genes like me logo Genes that share phenotypes with WNT5A: view

Animal Models for WNT5A Gene

MGI Knock Outs for WNT5A:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for WNT5A Gene

Localization for WNT5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT5A Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WNT5A Gene COMPARTMENTS Subcellular localization image for WNT5A gene
Compartment Confidence
extracellular 5
golgi apparatus 3
plasma membrane 3
cytoskeleton 2
nucleus 2
cytosol 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for WNT5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 18703641
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005796 Golgi lumen TAS --
genes like me logo Genes that share ontologies with WNT5A: view

Pathways for WNT5A Gene

genes like me logo Genes that share pathways with WNT5A: view

Gene Ontology (GO) - Biological Process for WNT5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IDA 20034610
GO:0001667 ameboidal-type cell migration IEA --
GO:0001736 establishment of planar polarity IEA --
GO:0001756 somitogenesis IEA --
GO:0001837 epithelial to mesenchymal transition IEP 12841867
genes like me logo Genes that share ontologies with WNT5A: view

Compounds for WNT5A Gene

(5) Novoseek inferred chemical compound relationships for WNT5A Gene

Compound -log(P) Hits PubMed IDs
glycogen 33.3 5
tyrosine 23.2 11
retinoic acid 0.428 4
calcium 0 8
paraffin 0 1
genes like me logo Genes that share compounds with WNT5A: view

Transcripts for WNT5A Gene

Unigene Clusters for WNT5A Gene

Wingless-type MMTV integration site family, member 5A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WNT5A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7
SP1: - - - - -
SP2: - - -
SP3:
SP4:
SP5: - -

Relevant External Links for WNT5A Gene

GeneLoc Exon Structure for
WNT5A
ECgene alternative splicing isoforms for
WNT5A

Expression for WNT5A Gene

mRNA expression in normal human tissues for WNT5A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT5A Gene

This gene is overexpressed in Bladder (4.8) and Esophagus - Mucosa (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WNT5A Gene

SOURCE GeneReport for Unigene cluster for WNT5A Gene Hs.643085

mRNA Expression by UniProt/SwissProt for WNT5A Gene

P41221-WNT5A_HUMAN
Tissue specificity: Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level).
genes like me logo Genes that share expressions with WNT5A: view

Orthologs for WNT5A Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT5A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WNT5A 36
  • 94.17 (n)
  • 93.44 (a)
WNT5A 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WNT5A 36
  • 94.21 (n)
  • 98.42 (a)
WNT5A 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WNT5A 36
  • 95.37 (n)
  • 99.72 (a)
WNT5A 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wnt5a 36
  • 90.09 (n)
  • 98.68 (a)
Wnt5a 16
Wnt5a 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WNT5A 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WNT5A 37
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wnt5a 36
  • 89.45 (n)
  • 98.15 (a)
chicken
(Gallus gallus)
Aves WNT5A 36
  • 84.74 (n)
  • 90 (a)
WNT5A 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WNT5A 37
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia wnt5a-B 36
tropical clawed frog
(Silurana tropicalis)
Amphibia wnt5a 36
  • 77.04 (n)
  • 84.7 (a)
zebrafish
(Danio rerio)
Actinopterygii wnt5a 36
wnt5a 36
  • 73.86 (n)
  • 76.99 (a)
wnt5a 37
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Wnt5 38
  • 52 (a)
Wnt6 38
  • 43 (a)
Wnt2 38
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea cwn-2 37
  • 41 (a)
OneToMany
egl-20 38
  • 33 (a)
mom-2 38
  • 33 (a)
cwn-2 38
  • 43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4951 37
  • 51 (a)
OneToMany
Species with no ortholog for WNT5A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT5A Gene

ENSEMBL:
Gene Tree for WNT5A (if available)
TreeFam:
Gene Tree for WNT5A (if available)

Paralogs for WNT5A Gene

Paralogs for WNT5A Gene

Selected SIMAP similar genes for WNT5A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with WNT5A: view

Variants for WNT5A Gene

Sequence variations from dbSNP and Humsavar for WNT5A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs472631 -- 55,477,647(-) AAGAG(C/T)CTGCT intron-variant
rs502912 -- 55,489,156(-) CCAAC(A/C)CTGCC upstream-variant-2KB
rs504849 -- 55,488,911(-) TATCC(A/G)TCAGC upstream-variant-2KB
rs506611 -- 55,488,741(-) CCGGT(C/G)GGTGG upstream-variant-2KB
rs556874 -- 55,473,253(-) TGGAC(A/G)GAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WNT5A Gene

Variant ID Type Subtype PubMed ID
nsv517851 CNV Gain 19592680
dgv1458e1 CNV Complex 17122850

Relevant External Links for WNT5A Gene

HapMap Linkage Disequilibrium report
WNT5A
Human Gene Mutation Database (HGMD)
WNT5A

Disorders for WNT5A Gene

(1) OMIM Diseases for WNT5A Gene (164975)

UniProtKB/Swiss-Prot

WNT5A_HUMAN
  • Robinow syndrome autosomal dominant (DRS) [MIM:180700]: A disease characterized by short-limb dwarfism, costovertebral segmentation defects and abnormalities of the head, face and external genitalia. The clinical signs are generally milder in dominant cases. {ECO:0000269 PubMed:19918918}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for WNT5A Gene

(14) Novoseek inferred disease relationships for WNT5A Gene

Disease -log(P) Hits PubMed IDs
breast cancer 38.3 33
invasive cancer 28.7 2
metastasis 27 11
tumors 25.8 31
cancer 23.2 16

Relevant External Links for WNT5A

Genetic Association Database (GAD)
WNT5A
Human Genome Epidemiology (HuGE) Navigator
WNT5A
genes like me logo Genes that share disorders with WNT5A: view

Publications for WNT5A Gene

  1. Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21. (PMID: 8288227) Clark C.C. … Iozzo R.V. (Genomics 1993) 2 3 4 23
  2. Wnt-5a has tumor suppressor activity in thyroid carcinoma. (PMID: 15735754) Kremenevskaja N. … Brabant G. (Oncogene 2005) 3 4 23
  3. Role of members of the Wnt gene family in human hematopoiesis. (PMID: 9787155) Van Den Berg D.J. … Hoffman R. (Blood 1998) 3 23
  4. Down-regulation of Wnt-4 and up-regulation of Wnt-5a expression by epithelial-mesenchymal transition in human squamous carcinoma cells. (PMID: 12841867) Taki M. … Nagayama M. (Cancer Sci. 2003) 3 23
  5. Sustained Wnt protein expression in chondral constructs from mesenchymal stem cells. (PMID: 15389636) Nishioka K. … Caplan A.I. (J. Cell. Physiol. 2005) 3 23

Products for WNT5A Gene

  • Addgene plasmids for WNT5A

Sources for WNT5A Gene

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