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Aliases for WNT5A Gene

Aliases for WNT5A Gene

  • Wnt Family Member 5A 2 3 5
  • Wingless-Type MMTV Integration Site Family, Member 5A 2 3
  • WNT-5A Protein 2 3
  • Protein Wnt-5a 3
  • HWNT5A 3

External Ids for WNT5A Gene

Previous GeneCards Identifiers for WNT5A Gene

  • GC03M054370
  • GC03M054625
  • GC03M055356
  • GC03M055458
  • GC03M055457

Summaries for WNT5A Gene

Entrez Gene Summary for WNT5A Gene

  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for WNT5A Gene

WNT5A (Wnt Family Member 5A) is a Protein Coding gene. Diseases associated with WNT5A include Robinow Syndrome, Autosomal Dominant 1 and Autosomal Dominant Robinow Syndrome. Among its related pathways are Validated targets of C-MYC transcriptional repression and Wnt Signaling Pathways: beta-Catenin-independent Wnt/Ca2+ Signaling and Other Non-canonical Wnt Signaling Pathways. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein domain specific binding. An important paralog of this gene is WNT5B.

UniProtKB/Swiss-Prot for WNT5A Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.

Gene Wiki entry for WNT5A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT5A Gene

Genomics for WNT5A Gene

Regulatory Elements for WNT5A Gene

Enhancers for WNT5A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G055475 2.4 VISTA FANTOM5 Ensembl ENCODE dbSUPER 4.3 +21.5 21456 16.9 HDGF PKNOX1 FEZF1 ZNF2 YY1 ZNF121 GLIS2 ZNF143 KLF7 FOS WNT5A WNT5A-AS1 GC03P055478
GH03G055511 1.1 Ensembl ENCODE dbSUPER 9.3 -7.2 -7223 1.4 PKNOX1 PRDM6 ZNF692 BHLHE40 FEZF1 ZBTB8A CHD7 ZIC2 ZNF423 WNT5A ENSG00000242317 LOC105377100
GH03G055188 1.5 FANTOM5 Ensembl ENCODE dbSUPER 6.4 +314.4 314433 4.5 GTF2F1 TBP STAT1 JUN BHLHE40 CEBPB EP300 NR2F2 JUND STAT3 WNT5A LINC02017 LOC105377097
GH03G055167 1.3 FANTOM5 ENCODE dbSUPER 6 +336.0 336000 4.5 GTF2F1 MXI1 JUN MAX SIN3A BRCA1 RFX5 NFYB FOS MAFK LRTM1 WNT5A WNT5A-AS1 ENSG00000239991
GH03G055159 1.6 FANTOM5 Ensembl ENCODE dbSUPER 3.4 +343.6 343597 5.0 TBL1XR1 TAF1 JUN MAX SIN3A EBF1 RAD21 ARID3A SMC3 SMARCC2 WNT5A ENSG00000239991 LRTM1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WNT5A on UCSC Golden Path with GeneCards custom track

Genomic Location for WNT5A Gene

Chromosome:
3
Start:
55,465,715 bp from pter
End:
55,505,261 bp from pter
Size:
39,547 bases
Orientation:
Minus strand

Genomic View for WNT5A Gene

Genes around WNT5A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNT5A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNT5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT5A Gene

Proteins for WNT5A Gene

  • Protein details for WNT5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41221-WNT5A_HUMAN
    Recommended name:
    Protein Wnt-5a
    Protein Accession:
    P41221
    Secondary Accessions:
    • A8K4A4
    • Q6P278

    Protein attributes for WNT5A Gene

    Size:
    380 amino acids
    Molecular mass:
    42339 Da
    Quaternary structure:
    • Homooligomer; disulfide-linked, leading to inactivation. Interacts with PORCN. Interacts with WLS (By similarity).

    Alternative splice isoforms for WNT5A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WNT5A Gene

Post-translational modifications for WNT5A Gene

  • Glycosylation is necessary for secretion but not for activity.
  • Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
  • Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT5A.
  • Glycosylation at Asn114, Asn120, Asn312, and posLast=326326
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WNT5A Gene

Domains & Families for WNT5A Gene

Gene Families for WNT5A Gene

Protein Domains for WNT5A Gene

Graphical View of Domain Structure for InterPro Entry

P41221

UniProtKB/Swiss-Prot:

WNT5A_HUMAN :
  • Belongs to the Wnt family.
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT5A: view

Function for WNT5A Gene

Molecular function for WNT5A Gene

GENATLAS Biochemistry:
wingless-type MMTV integration site 5A,Drosophila wingless (wg) segment polarity gene homolog,expressed in developing face,ventral area of midbrain,limbs an in adult brain,lung,modulating cell fate and cell behavior during vertebrate development
UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.

LifeMap Function Summary for WNT5A Gene

Gene Ontology (GO) - Molecular Function for WNT5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding IMP 19847889
GO:0005102 receptor binding IEA --
GO:0005109 frizzled binding IPI 18174455
GO:0005110 frizzled-2 binding IEA --
GO:0005115 receptor tyrosine kinase-like orphan receptor binding IPI 18287027
genes like me logo Genes that share ontologies with WNT5A: view
genes like me logo Genes that share phenotypes with WNT5A: view

Human Phenotype Ontology for WNT5A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for WNT5A Gene

MGI Knock Outs for WNT5A:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for WNT5A Gene

Localization for WNT5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT5A Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WNT5A gene
Compartment Confidence
plasma membrane 5
extracellular 5
golgi apparatus 5
endoplasmic reticulum 4
cytoskeleton 2
nucleus 2
mitochondrion 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for WNT5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 18703641
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005796 Golgi lumen TAS --
genes like me logo Genes that share ontologies with WNT5A: view

Pathways & Interactions for WNT5A Gene

genes like me logo Genes that share pathways with WNT5A: view

Pathways by source for WNT5A Gene

SIGNOR curated interactions for WNT5A Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for WNT5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IDA 20034610
GO:0001667 ameboidal-type cell migration IEA --
GO:0001736 establishment of planar polarity IEA --
GO:0001756 somitogenesis IEA --
GO:0001819 positive regulation of cytokine production IEA --
genes like me logo Genes that share ontologies with WNT5A: view

Drugs & Compounds for WNT5A Gene

(2) Drugs for WNT5A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for WNT5A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with WNT5A: view

Transcripts for WNT5A Gene

Unigene Clusters for WNT5A Gene

Wingless-type MMTV integration site family, member 5A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for WNT5A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7
SP1: - - - - -
SP2: - - -
SP3:
SP4:
SP5: - -

Relevant External Links for WNT5A Gene

GeneLoc Exon Structure for
WNT5A
ECgene alternative splicing isoforms for
WNT5A

Expression for WNT5A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WNT5A Gene

mRNA differential expression in normal tissues according to GTEx for WNT5A Gene

This gene is overexpressed in Bladder (x4.8) and Esophagus - Mucosa (x4.2).

Protein differential expression in normal tissues from HIPED for WNT5A Gene

This gene is overexpressed in Lung (48.5) and Ovary (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WNT5A Gene



Protein tissue co-expression partners for WNT5A Gene

NURSA nuclear receptor signaling pathways regulating expression of WNT5A Gene:

WNT5A

SOURCE GeneReport for Unigene cluster for WNT5A Gene:

Hs.643085

mRNA Expression by UniProt/SwissProt for WNT5A Gene:

P41221-WNT5A_HUMAN
Tissue specificity: Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level).

Evidence on tissue expression from TISSUES for WNT5A Gene

  • Kidney(4.3)
  • Nervous system(2.7)
  • Bone(2)
  • Lung(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for WNT5A Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • integumentary
  • nervous
  • reproductive
  • skeletal muscle
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • cheek
  • chin
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • outer ear
  • skull
  • tongue
  • tooth
Thorax:
  • chest wall
  • clavicle
  • heart
  • heart valve
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • abdominal wall
  • intestine
  • kidney
Pelvis:
  • pelvis
  • penis
  • testicle
  • ureter
  • vagina
  • vulva
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • hair
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with WNT5A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for WNT5A Gene

Orthologs for WNT5A Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT5A Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia WNT5A 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WNT5A 34 35
  • 95.37 (n)
cow
(Bos Taurus)
Mammalia WNT5A 34 35
  • 94.21 (n)
chimpanzee
(Pan troglodytes)
Mammalia WNT5A 34 35
  • 94.17 (n)
oppossum
(Monodelphis domestica)
Mammalia WNT5A 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wnt5a 34 16 35
  • 90.09 (n)
rat
(Rattus norvegicus)
Mammalia Wnt5a 34
  • 89.45 (n)
chicken
(Gallus gallus)
Aves WNT5A 34 35
  • 84.74 (n)
lizard
(Anolis carolinensis)
Reptilia WNT5A 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wnt5a 34
  • 77.04 (n)
African clawed frog
(Xenopus laevis)
Amphibia wnt5a-B 34
zebrafish
(Danio rerio)
Actinopterygii wnt5a 34 34 35
  • 73.86 (n)
fruit fly
(Drosophila melanogaster)
Insecta Wnt5 36
  • 52 (a)
Wnt6 36
  • 43 (a)
Wnt2 36
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea cwn-2 35 36
  • 41 (a)
OneToMany
egl-20 36
  • 33 (a)
mom-2 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4951 35
  • 51 (a)
OneToMany
Species where no ortholog for WNT5A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT5A Gene

ENSEMBL:
Gene Tree for WNT5A (if available)
TreeFam:
Gene Tree for WNT5A (if available)

Paralogs for WNT5A Gene

Paralogs for WNT5A Gene

(17) SIMAP similar genes for WNT5A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with WNT5A: view

Variants for WNT5A Gene

Sequence variations from dbSNP and Humsavar for WNT5A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs387906663 Pathogenic, Robinow syndrome, autosomal dominant 1 (DRS1) [MIM:180700] 55,474,477(-) GCGGC(C/T)GCGGC reference, missense
rs786200925 Pathogenic, Robinow syndrome, autosomal dominant 1 (DRS1) [MIM:180700] 55,479,457(-) ACTGT(C/G)CCACT reference, missense
rs786204836 Pathogenic 55,479,448(-) CTTGT(A/G)TCAGG reference, missense
rs786204837 Pathogenic 55,479,499(-) TCTCT(A/G)CAGCC reference, missense
rs869312850 Pathogenic 55,474,476(-) CGGCT(C/G)CGGCG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for WNT5A Gene

Variant ID Type Subtype PubMed ID
esv2759150 CNV loss 17122850
nsv1013405 CNV gain 25217958
nsv1144041 CNV deletion 24896259
nsv517851 CNV gain 19592680
nsv954869 CNV deletion 24416366

Variation tolerance for WNT5A Gene

Residual Variation Intolerance Score: 17.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WNT5A Gene

Human Gene Mutation Database (HGMD)
WNT5A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WNT5A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT5A Gene

Disorders for WNT5A Gene

MalaCards: The human disease database

(10) MalaCards diseases for WNT5A Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
robinow syndrome, autosomal dominant 1
  • autosomal dominant robinow syndrome 1
autosomal dominant robinow syndrome
  • fetal face syndrome
robinow syndrome
  • acral dysostosis with facial and genital abnormalities
epstein-barr virus-associated gastric carcinoma
  • ebv-associated gastric carcinoma
zimmermann-laband syndrome
  • laband syndrome
- elite association - COSMIC cancer census association via MalaCards
Search WNT5A in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

WNT5A_HUMAN
  • Robinow syndrome, autosomal dominant 1 (DRS1) [MIM:180700]: A disease characterized by short-limb dwarfism, costovertebral segmentation defects and abnormalities of the head, face and external genitalia. The clinical signs are generally milder in dominant cases. {ECO:0000269 PubMed:19918918}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for WNT5A

Genetic Association Database (GAD)
WNT5A
Human Genome Epidemiology (HuGE) Navigator
WNT5A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WNT5A
genes like me logo Genes that share disorders with WNT5A: view

No data available for Genatlas for WNT5A Gene

Publications for WNT5A Gene

  1. Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21. (PMID: 8288227) Clark C.C. … Iozzo R.V. (Genomics 1993) 2 3 4 22 64
  2. Wnt-5a has tumor suppressor activity in thyroid carcinoma. (PMID: 15735754) Kremenevskaja N. … Brabant G. (Oncogene 2005) 3 4 22 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study. (PMID: 20525402) MAPller M. … Hoal E.G. (BMC Infect. Dis. 2010) 3 46 64
  5. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 46 64

Products for WNT5A Gene

  • Addgene plasmids for WNT5A

Sources for WNT5A Gene

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