Aliases for WNT5A Gene
Aliases for WNT5A Gene
External Ids for WNT5A Gene
- HGNC: 12784
- Entrez Gene: 7474
- Ensembl: ENSG00000114251
- OMIM: 164975
- UniProtKB: P41221
Previous GeneCards Identifiers for WNT5A Gene
- GC03M054370
- GC03M054625
- GC03M055356
- GC03M055458
- GC03M055457
Summaries for WNT5A Gene
-
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
GeneCards Summary for WNT5A Gene
WNT5A (Wnt Family Member 5A) is a Protein Coding gene. Diseases associated with WNT5A include Robinow Syndrome, Autosomal Dominant 1 and Autosomal Dominant Robinow Syndrome. Among its related pathways are Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling and HTLV-I infection. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein domain specific binding. An important paralog of this gene is WNT5B.
UniProtKB/Swiss-Prot for WNT5A Gene
-
Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT5A Gene
Genomics for WNT5A Gene
Regulatory Elements for WNT5A Gene
Enhancers for WNT5A Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH03F055475 | 2.1 | VISTA FANTOM5 Ensembl ENCODE | 4.3 | +21.5 | 21456 | 16.9 | HDGF PKNOX1 FEZF1 ZNF2 ZNF121 GLIS2 ZNF143 KLF7 FOS TSHZ1 | WNT5A WNT5A-AS1 GC03P055478 |
| GH03F055511 | 0.9 | Ensembl ENCODE | 9.3 | -7.3 | -7332 | 1.6 | PKNOX1 ZNF692 GLIS1 BHLHE40 FEZF1 ZBTB8A ZIC2 ZNF423 | WNT5A ENSG00000242317 LOC105377100 |
| GH03F055188 | 1.3 | FANTOM5 Ensembl ENCODE | 6.4 | +314.4 | 314433 | 4.5 | GTF2F1 TBP STAT1 JUN BHLHE40 CEBPB EP300 NR2F2 JUND STAT3 | WNT5A LINC02017 LOC105377097 |
| GH03F055167 | 1.3 | FANTOM5 Ensembl ENCODE | 6 | +336.0 | 336000 | 4.5 | GTF2F1 MXI1 JUN MAX SIN3A BRCA1 RFX5 NFYB FOS MAFK | LRTM1 WNT5A WNT5A-AS1 ENSG00000239991 |
| GH03F055159 | 1.4 | FANTOM5 Ensembl ENCODE | 3.4 | +343.6 | 343597 | 5.0 | TBL1XR1 TAF1 JUN MAX SIN3A EBF1 RAD21 SMARCC2 SMC3 FOS | WNT5A ENSG00000239991 LRTM1 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around WNT5A on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the WNT5A gene promoter:
Regulatory Element Products
Genomic Location for WNT5A Gene
- Chromosome:
- 3
- Start:
- 55,465,715 bp from pter
- End:
- 55,505,261 bp from pter
- Size:
- 39,547 bases
- Orientation:
- Minus strand
Genomic View for WNT5A Gene
Genes around WNT5A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3p14.3 by Ensembl
- 3p14.3 by Entrez Gene
- 3p14.3 by HGNC
WNT5A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for WNT5A Gene
Proteins for WNT5A Gene
-
Protein details for WNT5A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P41221-WNT5A_HUMAN
- Recommended name:
- Protein Wnt-5a
- Protein Accession:
- P41221
- A8K4A4
- Q6P278
Protein attributes for WNT5A Gene
- Size:
- 380 amino acids
- Molecular mass:
- 42339 Da
- Quaternary structure:
-
- Homooligomer; disulfide-linked, leading to inactivation. Interacts with PORCN. Interacts with WLS (By similarity).
Protein Expression for WNT5A Gene
Post-translational modifications for WNT5A Gene
- Glycosylation is necessary for secretion but not for activity.
- Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
- Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT5A.
- Glycosylation at Asn 114, Asn 120, Asn 312, and Asn 326
- Modification sites at PhosphoSitePlus
Other Protein References for WNT5A Gene
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for WNT5A
- R&D Systems Antibodies for WNT5A (Wnt-5a)
- Cell Signaling Technology (CST) Antibodies for WNT5A (WNT5A)
-
Custom Antibody ServicesOriGene Antibodies for WNT5A
- Novus Biologicals Antibodies for WNT5A
- Invitrogen Antibodies for WNT5A
- antibodies-online Antibodies for WNT5A: See all 99
- GeneTex WNT5A antibody for WNT5A
-
St John's Laboratory Antibodies for WNT5A
-
Santa Cruz Biotechnology (SCBT) Antibodies for WNT5A
Protein Products
- EMD Millipore Purified and/or Recombinant WNT5A Protein
- R&D Systems Proteins and Enzymes for WNT5A (Wnt-5a)
-
OriGene Purified Proteins for WNT5A
- Search Origene for MassSpec and Protein Over-expression Lysates for WNT5A
- Origene Custom Protein Services for WNT5A
- antibodies-online Proteins for WNT5A: See all 16
- Search antibodies-online for peptides
- Search GeneTex for Proteins for WNT5A
Assay Products
- antibodies-online Kits for WNT5A: See all 17
No data available for DME Specific Peptides for WNT5A Gene
Domains & Families for WNT5A Gene
Gene Families for WNT5A Gene
Protein Domains for WNT5A Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for WNT5A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P41221- Family:
-
- Belongs to the Wnt family.
Function for WNT5A Gene
Molecular function for WNT5A Gene
- GENATLAS Biochemistry:
- wingless-type MMTV integration site 5A,Drosophila wingless (wg) segment polarity gene homolog,expressed in developing face,ventral area of midbrain,limbs an in adult brain,lung,modulating cell fate and cell behavior during vertebrate development
- UniProtKB/Swiss-Prot Function:
- Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.
LifeMap Function Summary for WNT5A Gene
During embryonic development, WNT5A as signaling molecule is secreted from the following cells
- Gut Tube
- Neural Tube
- Primitive Streak
It affects the following cells:
- Gut Tube
- Primitive Streak
- Neural Tube
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | IMP | 19847889 |
| GO:0005102 | receptor binding | IEA | -- |
| GO:0005109 | frizzled binding | IPI | 18174455 |
| GO:0005110 | frizzled-2 binding | IEA | -- |
| GO:0005115 | receptor tyrosine kinase-like orphan receptor binding | IPI | 18287027 |
Phenotypes for WNT5A Gene
- MGI mutant phenotypes for WNT5A:
-
inferred from 4 alleles
- cellular phenotype
- mortality/aging
- growth/size/body region phenotype
- nervous system phenotype
- homeostasis/metabolism phenotype
- normal phenotype
- respiratory system phenotype
- immune system phenotype
- cardiovascular system phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- liver/biliary system phenotype
- hematopoietic system phenotype
- digestive/alimentary phenotype
- embryo phenotype
- hearing/vestibular/ear phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- renal/urinary system phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for WNT5A:
Animal Models for WNT5A Gene
- MGI Knock Outs for WNT5A:
-
- Wnt5a tm1Amc
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for WNT5A
-
-
ViGene Biosciences lentiviral particle packaged cDNA for WNT5A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for WNT5A gene
- Search ViGene Biosciences for WNT5A
CRISPR Products
-
OriGene CRISPR knockouts for WNT5A
- GenScript: Design CRISPR guide RNA sequences for WNT5A
miRNA for WNT5A Gene
- miRTarBase miRNAs that target WNT5A
-
- hsa-mir-30a-5p (MIRT005162)
- hsa-mir-155-5p (MIRT020965)
- hsa-mir-186-5p (MIRT021154)
- hsa-mir-21-5p (MIRT030983)
- hsa-mir-16-5p (MIRT031969)
- hsa-mir-92a-3p (MIRT049710)
- hsa-mir-624-3p (MIRT053729)
- hsa-mir-374a-5p (MIRT054742)
- hsa-let-7c-3p (MIRT163389)
- hsa-mir-190a-3p (MIRT163408)
- hsa-mir-1277-5p (MIRT163466)
- hsa-mir-4307 (MIRT163479)
- hsa-mir-5011-5p (MIRT163508)
- hsa-mir-487b-3p (MIRT437852)
- hsa-mir-218-5p (MIRT439283)
- hsa-mir-578 (MIRT444470)
- hsa-mir-4762-3p (MIRT444471)
- hsa-mir-4452 (MIRT444472)
- hsa-mir-183-3p (MIRT444473)
- hsa-mir-526b-5p (MIRT444474)
- hsa-mir-4635 (MIRT444475)
- hsa-mir-5187-3p (MIRT444476)
- hsa-mir-4680-3p (MIRT444477)
- hsa-mir-4427 (MIRT444478)
- hsa-mir-33a-3p (MIRT444479)
- hsa-mir-6083 (MIRT520160)
- hsa-mir-3924 (MIRT520161)
- hsa-mir-26b-5p (MIRT726095)
- hsa-mir-26a-5p (MIRT726096)
miRNA Products
- Search ViGene Biosciences for WNT5A
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for WNT5A
- VectorBuilder custom plasmid, inducible vectors for WNT5A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for WNT5A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
- ESI BIO PureStem Z11, Meso Progenitor for WNT5A
-
Horizon Cell Lines for WNT5A
-
ViGene Biosciences adenoviral particle packaged cDNA for WNT5A gene
-
ViGene Biosciences lentiviral particle packaged cDNA for WNT5A gene
-
ViGene Biosciences ready-to-package AAV shRNAs for WNT5A gene
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-12202) for WNT5A
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for WNT5A Gene
Localization for WNT5A Gene
Subcellular locations from UniProtKB/Swiss-Prot for WNT5A Gene
- Secreted, extracellular space, extracellular matrix.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| golgi apparatus | 5 |
| endoplasmic reticulum | 4 |
| cytoskeleton | 2 |
| nucleus | 2 |
| mitochondrion | 1 |
| cytosol | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA,TAS | -- |
| GO:0005578 | proteinaceous extracellular matrix | IEA | -- |
| GO:0005615 | extracellular space | IDA | 18703641 |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
| GO:0005796 | Golgi lumen | TAS | -- |
Pathways & Interactions for WNT5A Gene
Pathways by source for WNT5A Gene
2 Sino Biological pathways for WNT5A Gene
2 GeneTex pathways for WNT5A Gene
1 Cell Signaling Technology pathway for WNT5A Gene
7 BioSystems pathways for WNT5A Gene
11 KEGG pathways for WNT5A Gene
2 GeneGo (Thomson Reuters) pathways for WNT5A Gene
5 R&D Systems pathways for WNT5A Gene
- Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers
- mTOR Signaling Pathway
- Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling
- Wnt Signaling Pathways: beta-Catenin-independent Wnt/Ca2+ Signaling and Other Non-canonical Wnt Signaling Pathways
- Wnt Signaling Pathways: beta-Catenin-independent Wnt/PCP Signaling Pathways
1 Tocris pathway for WNT5A Gene
8 Qiagen pathways for WNT5A Gene
Interacting Proteins for WNT5A Gene
Selected Interacting proteins:
ENSP00000264634
P41221-WNT5A_HUMAN
for WNT5A Gene via
STRING
IID
UniProtKB
SIGNOR curated interactions for WNT5A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000187 | activation of MAPK activity | IDA | 20034610 |
| GO:0001667 | ameboidal-type cell migration | IEA | -- |
| GO:0001736 | establishment of planar polarity | IEA | -- |
| GO:0001756 | somitogenesis | IEA | -- |
| GO:0001819 | positive regulation of cytokine production | IEA | -- |
Transcripts for WNT5A Gene
mRNA/cDNA for WNT5A Gene
- (10) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (129) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for WNT5A Gene
CRISPR Products
-
OriGene CRISPR knockouts for WNT5A
- GenScript: Design CRISPR guide RNA sequences for WNT5A
miRNA Products
- Search ViGene Biosciences for WNT5A
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for WNT5A
- VectorBuilder custom plasmid, inducible vectors for WNT5A
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for WNT5A
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-12202) for WNT5A
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||
| SP3: | |||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||
| SP5: | - | - |
Expression for WNT5A Gene
mRNA differential expression in normal tissues according to GTEx for WNT5A Gene
This gene is overexpressed in Bladder (x4.8) and Esophagus - Mucosa (x4.2).
This gene is overexpressed in Lung (48.5) and Ovary (9.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WNT5A Gene
NURSA nuclear receptor signaling pathways regulating expression of WNT5A Gene:
WNT5ASOURCE GeneReport for Unigene cluster for WNT5A Gene:
Hs.643085mRNA Expression by UniProt/SwissProt for WNT5A Gene:
P41221-WNT5A_HUMAN
Tissue specificity:
Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level).
Primer Products
-
OriGene qPCR primer pairs for WNT5A
-
OriGene qPCR primer pairs and template standards for WNT5A
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for WNT5A Gene
Orthologs for WNT5A Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| platypus (Ornithorhynchus anatinus) |
Mammalia | WNT5A 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | WNT5A 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | WNT5A 34 35 |
|
||
| chimpanzee (Pan troglodytes) |
Mammalia | WNT5A 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | WNT5A 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Wnt5a 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Wnt5a 34 |
|
||
| chicken (Gallus gallus) |
Aves | WNT5A 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | WNT5A 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | wnt5a 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | wnt5a-B 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | wnt5a 34 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Wnt5 36 |
|
|
|
| Wnt6 36 |
|
|
|||
| Wnt2 36 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | cwn-2 36 35 |
|
||
| egl-20 36 |
|
|
|||
| mom-2 36 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4951 35 |
|
OneToMany |
- Species where no ortholog for WNT5A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for WNT5A Gene
Paralogs for WNT5A Gene
(17) SIMAP similar genes for WNT5A Gene using alignment to 4 proteins:
Variants for WNT5A Gene
| SNP ID | Clin | Chr 03 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs387906663 | Robinow syndrome, autosomal dominant 1 (DRS1) [MIM:180700], Pathogenic | 55,474,477(-) | GCGGC(C/T)GCGGC | reference, missense | |
| rs786200925 | Robinow syndrome, autosomal dominant 1 (DRS1) [MIM:180700], Pathogenic | 55,479,457(-) | ACTGT(C/G)CCACT | reference, missense | |
| rs786204836 | Pathogenic | 55,479,448(-) | CTTGT(A/G)TCAGG | reference, missense | |
| rs786204837 | Pathogenic | 55,479,499(-) | TCTCT(A/G)CAGCC | reference, missense | |
| rs869312850 | Pathogenic | 55,474,476(-) | CGGCT(C/G)CGGCG | reference, missense |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv954869 | CNV | deletion | 24416366 |
| nsv517851 | CNV | gain | 19592680 |
| nsv1144041 | CNV | deletion | 24896259 |
| nsv1013405 | CNV | gain | 25217958 |
| esv2759150 | CNV | loss | 17122850 |
Residual Variation Intolerance Score:
17.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.89;
18.61% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for WNT5A Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT5A Gene
Disorders for WNT5A Gene
(10) MalaCards diseases for WNT5A Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| robinow syndrome, autosomal dominant 1 |
|
|
| autosomal dominant robinow syndrome |
|
|
| zimmermann-laband syndrome |
|
|
| estrogen-receptor negative breast cancer |
|
|
| epstein-barr virus-associated gastric carcinoma |
|
|
Search WNT5A in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
WNT5A_HUMAN- Robinow syndrome, autosomal dominant 1 (DRS1) [MIM:180700]: A disease characterized by short-limb dwarfism, costovertebral segmentation defects and abnormalities of the head, face and external genitalia. The clinical signs are generally milder in dominant cases. {ECO:0000269 PubMed:19918918}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for WNT5A
No data available for Genatlas for WNT5A Gene
Publications for WNT5A Gene
- Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21. (PMID: 8288227) Clark C.C. … Iozzo R.V. (Genomics 1993) 2 3 4 22 64
- Wnt-5a has tumor suppressor activity in thyroid carcinoma. (PMID: 15735754) Kremenevskaja N. … Brabant G. (Oncogene 2005) 3 4 22 64
- Wnt5a regulates distinct signalling pathways by binding to Frizzled2. (PMID: 19910923) Sato A. … Kikuchi A. (EMBO J. 2010) 3 22 64
- Expression of Wnt5a in tooth germs and the related signal transduction analysis. (PMID: 20034610) Peng L. … Ye L. (Arch. Oral Biol. 2010) 3 22 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
Products for WNT5A Gene
- Browse Small Molecules at EMD Millipore
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for WNT5A
- EMD Millipore Purified and/or Recombinant WNT5A Protein
- Browse Kits and Assays available from EMD Millipore
- EMD Millipore genomic analysis products
- R&D Systems Antibodies for WNT5A (Wnt-5a)
- R&D Systems Proteins and Enzymes for WNT5A (Wnt-5a)
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
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- Custom Antibody ServicesOriGene Antibodies for WNT5A
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- Novus Biologicals Antibodies for WNT5A
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- ESI BIO PureStem Z11, Meso Progenitor for WNT5A
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- antibodies-online Antibodies for WNT5A: See all 99
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- GeneTex WNT5A antibody for WNT5A
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- ViGene Biosciences adenoviral particle packaged cDNA for WNT5A gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for WNT5A
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- Horizon Cell Lines for WNT5A
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- VectorBuilder custom plasmid, inducible vectors for WNT5A
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
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- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for WNT5A Gene
- (1) GeneCards
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- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
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- (42) dbSNP
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- (44) GeneTests
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- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
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- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
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- (62) NCBI
- (63) OriGene
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- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
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- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
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- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
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- (98) BioGPS
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- (100) COMPARTMENTS
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- (104) Addgene
- (105) antibodies-online
- (106) CYP
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- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
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- (143) Horizon
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- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
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- (150) St John's Lab