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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WNT5A Gene

protein-coding   GIFtS: 72
GCID: GC03M055474

Wingless-Type MMTV Integration Site Family, Member 5A
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Aliases
for WNT5A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Wingless-Type MMTV Integration Site Family, Member 5A1 2
WNT-5A Protein1 2
hWNT5A2
Protein Wnt-5a2

External Ids:    HGNC: 127841   Entrez Gene: 74742   Ensembl: ENSG000001142517   OMIM: 1649755   UniProtKB: P412213   

Export aliases for WNT5A gene to outside databases

Previous GC identifers: GC03M054370 GC03M054625 GC03M055356 GC03M055458 GC03M055457


Summaries
for WNT5A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for WNT5A Gene:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins
have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and
patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical
and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the
tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during
embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal
dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. (provided by RefSeq, Jan 2012)

GeneCards Summary for WNT5A Gene: 
WNT5A (wingless-type MMTV integration site family, member 5A) is a protein-coding gene. Diseases associated with WNT5A include laband syndrome, and zimmermann-laband syndrome, and among its related super-pathways are Wnt signaling pathway and Basal cell carcinoma. GO annotations related to this gene include cytokine activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is WNT5B.

UniProtKB/Swiss-Prot: WNT5A_HUMAN, P41221
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical
Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the
presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent
pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical
pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases
proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor.
Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior
axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes

Gene Wiki entry for WNT5A Gene


Genomic Views
for WNT5A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WNT5A gene promoter:
         GATA-3   AP-1   ATF-2   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   Egr-4   COMP1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): WNT5A promoter sequence
   Search SABiosciences Chromatin IP Primers for WNT5A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WNT5A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21-p14   Ensembl cytogenetic band:  3p14.3   HGNC cytogenetic band: 3p21-p14

WNT5A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT5A gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M055474:  view genomic region     (about GC identifiers)

Start:
 55,499,743 bp from pter      End:
 55,523,973 bp from pter
Size:
 24,231 bases      Orientation:
 minus strand

Proteins
for WNT5A gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: WNT5A_HUMAN, P41221 (See protein sequence)
Recommended Name: Protein Wnt-5a precursor  
Size: 380 amino acids; 42339 Da
Subunit: Homooligomer; disulfide-linked, leading to inactivation. Interacts with PORCN. Interacts with WLS (By
similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix
Secondary accessions: A8K4A4 Q6P278
Alternative splicing: 2 isoforms:  P41221-1   P41221-2   

Explore the universe of human proteins at neXtProt for WNT5A: NX_P41221

Explore proteomics data for WNT5A at MOPED 

Post-translational modifications:

  • UniProtKB: Palmitoylation is necessary for stimulation of cell migration, inhibition of the beta-catenin pathway and receptor
    • binding (By similarity)
  • UniProtKB: Glycosylation is necessary for secretion but not for activity (By similarity)
  • UniProtKB: Palmitoylation at Ser-244 is required for efficient binding to frizzled receptors. It is also required for subsequent
    • palmitoylation at Cys-104. Palmitoylation is necessary for proper trafficking to cell surface (By similarity)
  • UniProtKB: Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading
    • to inactivation of WNT5A (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P41221

    • WNT5A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WNT5A Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001243034.1  NP_003383.2  

    ENSEMBL proteins: 
     ENSP00000417310   ENSP00000420104   ENSP00000418184   ENSP00000264634  
    Reactome Protein details: P41221
    Human Recombinant Protein Products for WNT5A: 
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    Novus Biologicals WNT5A Proteins
    Novus Biologicals WNT5A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WNT5A 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IDA18703641
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005796Golgi lumen TAS--

    WNT5A for ontologies           About GeneDecksing



    WNT5A Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for WNT5A 

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    Cloud-Clone Corp. ELISAs for WNT5A 
    Cloud-Clone Corp. CLIAs for WNT5A

    Protein Domains /
    Families
    for WNT5A gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    ENDOLIG: Endogenous ligands
    WNT: Wingless-type MMTV integration sites

    3 InterPro protein domains:
     IPR026538 Wnt5a
     IPR005817 Wnt
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry P41221

    ProtoNet protein and cluster: P41221

    1 Blocks protein domain: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WNT5A_HUMAN, P41221
    Similarity: Belongs to the Wnt family


    WNT5A for domains           About GeneDecksing


    Function
    for WNT5A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WNT5A_HUMAN, P41221
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical
    Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the
    presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent
    pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical
    pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases
    proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor.
    Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior
    axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes

         Genatlas biochemistry entry for WNT5A:
    wingless-type MMTV integration site 5A,Drosophila wingless (wg) segment polarity gene homolog,expressed in developing
    face,ventral area of midbrain,limbs an in adult brain,lung,modulating cell fate and cell behavior during vertebrate
    development

         Summary:
    During embryonic development, WNT5A as signaling molecule is secreted from the following cells: Floor Plate Cells in Spinal Floor Plate It affects the following cells: Somatic Motor Neurons in Motor Neural Progenitor Domain

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IMP19847889
    GO:0005102receptor binding ----
    GO:0005109frizzled binding IPI18174455
    GO:0005110frizzled-2 binding IEA--
    GO:0005115receptor tyrosine kinase-like orphan receptor binding IPI18287027
         
    WNT5A for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for WNT5A:
     Increased G1 DNA content  Synthetic lethal with imatinib 

         15 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Wnt5a):
     cellular  craniofacial  digestive/alimentary  embryogenesis  growth/size 
     hearing/vestibular/ear  homeostasis/metabolism  limbs/digits/tail  liver/biliary system  mortality/aging 
     nervous system  renal/urinary system  reproductive system  respiratory system  skeleton 

    WNT5A for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Wnt5atm1Amc for WNT5A
       inGenious Targeting Laboratory - Custom generated mouse model solutions for WNT5A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for WNT5A

    miRNA
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    hsa-mir-30a (MIRT005162)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WNT5A
    8/85 QIAGEN miScript miRNA Assays for microRNAs that regulate WNT5A (see all 85):
    hsa-miR-576-3p hsa-miR-323-3p hsa-miR-579 hsa-miR-520f hsa-miR-300 hsa-miR-218-1* hsa-miR-200a hsa-miR-3074-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Pathways & Interactions
    for WNT5A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for WNT5A About   (see all 24)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway
    		Wnt signaling pathway0.40
    		Wnt Signaling Pathway NetPath0.37
    		Wnt Signaling Pathway0.40
    2Basal cell carcinoma
    		Hedgehog signaling pathway0.43
    		Wnt Pathway0.39
    		Basal cell carcinoma0.43
    		Melanogenesis0.32
    3Wnt Signaling Pathway
    		Wnt Signaling Pathway0.55
    		DNA damage response (only ATM dependent)0.32
    		Wnt Signaling Pathway and Pluripotency0.55
    4Signaling by GPCR
    		Signaling by GPCR0.90
    		Signal Transduction0.55
    5Asparagine N-linked glycosylation
    		WNT ligand biogenesis and trafficking0.77
    		Signaling by Wnt0.62

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for WNT5A
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    1 R&D Systems Pathway for WNT5A
        Wnt Signaling Pathway

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for WNT5A (see all 8)
        GSK3 Signaling
    Molecular Mechanisms of Cancer
    Presenilin-Mediated Signaling
    Human Embryonic Stem Cell Pluripotency
    Colorectal Cancer Metastasis

    1 Cell Signaling Technology (CST) Pathway for WNT5A
        Wnt / Hedgehog / Notch

    1 Tocris Bioscience Pathway for WNT5A
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT5A
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    5/8 BioSystems Pathways for WNT5A (see all 8)
        MicroRNAs in cardiomyocyte hypertrophy
    Wnt Signaling Pathway
    DNA damage response (only ATM dependent)
    Wnt Signaling Pathway and Pluripotency
    Wnt Signaling Pathway NetPath


    5/6        Reactome Pathways for WNT5A (see all 6)
        Signaling by Wnt
    Signal Transduction
    Signaling by GPCR
    WNT ligand biogenesis and trafficking
    GPCR ligand binding


    5/8         Kegg Pathways  (Kegg details for WNT5A) (see all 8):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection


    WNT5A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WNT5A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/37 Interacting proteins for WNT5A (P412213 ENSP000002646344) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FZD1Q9UP383, ENSP000002879344I2D: score=3 STRING: ENSP00000287934
    FZD5Q134673, ENSP000003546074I2D: score=1 STRING: ENSP00000354607
    LRP6O755813, ENSP000002613494I2D: score=1 STRING: ENSP00000261349
    ROR2Q019743, ENSP000003648604I2D: score=2 STRING: ENSP00000364860
    PORCNQ9H2373, ENSP000003223044I2D: score=3 STRING: ENSP00000322304
    About this table

    Gene Ontology (GO): 5/130 biological process terms (GO ID links to tree view) (see all 130):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IDA--
    GO:0001667ameboidal cell migration IEA--
    GO:0001736establishment of planar polarity IEA--
    GO:0001756somitogenesis IEA--
    GO:0001837epithelial to mesenchymal transition IEP12841867

    WNT5A for ontologies           About GeneDecksing



    Drugs & Compounds
    for WNT5A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    WNT5A for compounds           About GeneDecksing

    EMD Millipore small molecules for WNT5A:
    Small Molecule - inhibitor
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    Browse Tocris compounds for WNT5A

    5 Novoseek inferred chemical compound relationships for WNT5A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycogen 33.3 6 10873564 (1), 18407462 (1), 17986005 (1), 12915680 (1) (see all 5)
    tyrosine 23.2 12 18615587 (3), 17986005 (2), 17463182 (1), 19561643 (1) (see all 8)
    retinoic acid 0.428 9 15592517 (3), 15925444 (1)
    calcium 0 8 17463182 (2), 18929644 (2), 14766423 (1), 19420254 (1) (see all 6)
    paraffin 0 1 14514922 (1)

    Search CenterWatch for drugs/clinical trials and news about WNT5A

    Transcripts
    for WNT5A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for WNT5A gene (2 alternative transcripts): 
    NM_001256105.1  NM_003392.4  

    Unigene Cluster for WNT5A:

    Wingless-type MMTV integration site family, member 5A
    Hs.643085  [show with all ESTs]
    Unigene Representative Sequence: NM_003392
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000474267(uc003dhm.3 uc010hmw.3 uc003dhn.3 uc010hmx.3)
    ENST00000493406 ENST00000497027 ENST00000482079 ENST00000497817 ENST00000264634

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Primer
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    Additional mRNA sequence: 

    AK021503.1 AK090582.1 AK290375.1 AK290869.1 BC064694.1 BC074783.2 EF028086.1 

    6 DOTS entries:

    DT.95294716  DT.440946  DT.120885032  DT.100744120  DT.102824816  DT.70101564 

    24/129 AceView cDNA sequences (see all 129):

    BC074783 AW069504 BF430942 AL700501 AW238894 BX503521 BE220278 AI683487 
    CB992663 AI750799 AI394540 AA932802 BE045609 BF589063 N51822 AI634753 
    AW055279 AA903835 AU118341 BM746350 AL079945 NM_003392 BE671209 AI339491 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for WNT5A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7
    SP1:              -     -     -           -     -                           
    SP2:              -     -     -                                             
    SP3:                                                                        
    SP4:                                                                        
    SP5:                    -     -                                             


    ECgene alternative splicing isoforms for WNT5A

    Expression
    for WNT5A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WNT5A expression in normal human tissues (normalized intensities)      WNT5A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATTCAGAT
    WNT5A Expression
    About this image


    WNT5A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/21 selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 13 entries
             Adult Endothelial Cells Blood Brain Barrier
             Midbrain tegmentum
             brain/midbrain
     
     Dermis (Integumentary System)    fully expand to see all 7 entries
             Dermal Mesenchyme Cells Dorsal Subectodermal Mesenchyme
             hair follicle sub-bulge
     
     Reproductive System (Reproductive System)    fully expand to see all 4 entries
             Testicular Interstitial Cells Testis Interstitium
             Primordial germ cell-like cells (Reconstitution of mouse germ cell from pluripotent...
             endometrium
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             nGnG Amacrine Cells Inner Nuclear Layer
             Outer Nuclear Layer
             sensory organ/eye/perioptic mesenchyme
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon

    See WNT5A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WNT5A

    SOURCE GeneReport for Unigene cluster: Hs.643085

    UniProtKB/Swiss-Prot: WNT5A_HUMAN, P41221
    Tissue specificity: Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and
    anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in
    stromal cells (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Arrays including WNT5A (see all 10): 
              Wound Healing in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Adipogenesis in human mouse rat
              Estrogen Receptor Signaling in human mouse rat
              Notch Signaling Targets in human mouse rat

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    Orthologs
    for WNT5A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for WNT5A gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Wnt5a1 , 5 wingless-related MMTV integration site 5A1, 5 90.09(n)1
    98.68(a)1    		   14 (16.80 cM)5
    224181  NM_009524.31  NP_033550.21 
     285047505 
    chicken
    (Gallus gallus)    		 Aves WNT5A1 wingless-type MMTV integration site family, member more 84.74(n)
    90(a)    		   395703  NM_204887.1  NP_990218.1 
    lizard
    (Anolis carolinensis)    		 Reptilia WNT5A6
    		 wingless-type MMTV integration site family, member...
    		 89(a)
    		 1 ↔ 1
    		 2(161755890-161775075)
    African clawed frog
    (Xenopus laevis)    		 Amphibia wnt5a-B2 wingless-type MMTV integration site family, member more 78.67(n)    L19716.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wnt5a2 wingless-type MMTV integration site family, member more 81.32(n)   30105  NM_130937.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Wnt53 Wnt receptor signaling pathway signal
    transducer    		 52(a)
    (best of 3)    		     --
    worm
    (Caenorhabditis elegans)    		 Secernentea cwn-23 WNT-2 precursor 43(a)
    (best of 3)    		   IV(10068050-10070141)   --


    ENSEMBL Gene Tree for WNT5A (if available)
    TreeFam Gene Tree for WNT5A (if available)

    Paralogs
    for WNT5A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WNT5A gene
    WNT5B2  WNT162  WNT62  WNT112  WNT22  WNT2B2  WNT3A2  WNT12  
    WNT42  WNT10B2  WNT7A2  WNT7B2  WNT32  WNT10A2  
    17 SIMAP similar genes for WNT5A using alignment to 4 protein entries:     WNT5A_HUMAN (see all proteins):
    WNT5B    WNT7B    WNT2B    WNT4    WNT2    WNT7A
    WNT3    WNT3A    WNT8A    WNT8B    WNT16    WNT1
    WNT11    WNT6    WNT9A    WNT9B    WNT10B

    WNT5A for paralogs           About GeneDecksing



    Genomic Variants
    for WNT5A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/466 SNPs in WNT5A are shown (see all 466)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    VAR_0666234
    		Robinow syndrome autosomal dominant (DRS)4--see VAR_0666232 C S mis40--------
    VAR_0666294
    		Robinow syndrome autosomal dominant (DRS)4--see VAR_0666292 C R mis40--------
    rs5903861,2
    		C,F,O,H--55432052(-) AAAACG/AATGTT 2 -- ds500121Minor allele frequency- A:0.13MN NS EA NA WA 2302
    rs795865241,2
    		F--55432053(+) ACATCG/ATTTTA 2 -- ds50012Minor allele frequency- A:0.04WA NA 238
    rs5895571,2
    		C,F--55432224(-) CATTTT/GTCTTT 2 -- ds500111Minor allele frequency- G:0.12EA NA MN WA 663
    rs764434201,2
    		F--55432272(+) ACCATA/GTCATC 2 -- ds50011Minor allele frequency- G:0.01WA 118
    rs1892330101,2
    		--55432296(+) TGTACA/GTGTGT 2 -- ds50010--------
    rs124972541,2
    		C,F,H--55432309(+) TTCTGA/GATACC 2 -- ds500130Minor allele frequency- N:0.00EA NA NS CSA WA 2962
    rs10478981,2
    		C,F,A,H--55432426(-) TTCATG/ATCTTG 2 -- ut3115Minor allele frequency- A:0.47MN NS EA NA CSA WA 970
    rs1816804181,2
    		--55432586(+) ACATTA/TAAAAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for WNT5A (55499743 - 55523973 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for WNT5A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv517851CNV Gain19592680
    dgv1458e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): WNT5A
    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for WNT5A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    WNT5A for disorders           About GeneDecksing

    OMIM gene information: 164975    OMIM disorders: --

    UniProtKB/Swiss-Prot: WNT5A_HUMAN, P41221
  • Robinow syndrome autosomal dominant (DRS) [MIM:180700]: A disease characterized by short-limb dwarfism,
    • costovertebral segmentation defects and abnormalities of the head, face and external genitalia. The clinical signs are
    generally milder in dominant cases. Note=The disease is caused by mutations affecting the gene represented in this
    entry

    20/50 diseases for WNT5A (see all 50):    About MalaCards
    laband syndrome    zimmermann-laband syndrome    autosomal dominant robinow syndrome    wnt5a-related robinow syndrome, autosomal dominant
    estrogen-receptor negative breast cancer    robinow syndrome    mayer-rokitansky-kuster-hauser syndrome    merkel cell carcinoma
    familial adenomatous polyposis    dwarfism    breast cancer susceptibility    cleft lip
    cleft palate    chronic myeloid leukemia    basal cell carcinoma    meningitis
    thyroid cancer    noma    colon cancer    skin cancer

    1 disease from the University of Copenhagen DISEASES database for WNT5A:
    Melanoma

    10/14 Novoseek inferred disease relationships for WNT5A gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 38.3 51 18927296 (4), 15701836 (3), 19237581 (3), 16880514 (3) (see all 18)
    invasive cancer 28.7 2 19901340 (1), 9815976 (1)
    metastasis 27 13 18927296 (2), 19901340 (2), 16880514 (2), 19244247 (1) (see all 8)
    tumors 25.8 38 11809689 (4), 16314637 (4), 15735754 (3), 15701836 (2) (see all 18)
    cancer 23.2 19 19603030 (4), 9367869 (2), 9716023 (2), 18294932 (1) (see all 11)
    melanoma 22.6 17 19901340 (4), 19470740 (3), 14514922 (2), 17992121 (1) (see all 9)
    mammary tumor 21.5 2 12471617 (1), 19519951 (1)
    familial adenomatous polyposis 10.4 1 17463182 (1)
    primary tumor 7.6 1 15701836 (1)
    carcinoma squamous cell 3.42 6 16314637 (3), 19467340 (1), 19956879 (1), 12841867 (1)

    Genetic Association Database (GAD): WNT5A
    Human Genome Epidemiology (HuGE) Navigator: WNT5A (10 documents)

    Export disorders for WNT5A gene to outside databases

    Publications
    for WNT5A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WNT5A gene, integrated from 9 sources (see all 274):
    (articles sorted by number of sources associating them with WNT5A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21. (PubMed id 8288227)1, 2, 3, 9 Clark C.C.... Iozzo R.V. (1993)
    2. Wnt-5a has tumor suppressor activity in thyroid carcinoma. (PubMed id 15735754)1, 2, 9 Kremenevskaja N....Brabant G. (2005)
    3. WNT5A mutations in patients with autosomal dominant R obinow syndrome. (PubMed id 19918918)1, 2 Person A.D....Lohr J.L. (2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Analysis of eight genes modulating interferon gamma a nd human genetic susceptibility to tuberculosis: a case-control association stu dy. (PubMed id 20525402)1, 4 MAPller M....Hoal E.G. (2010)
    6. Studies with Wnt genes and nonsyndromic cleft lip and palate. (PubMed id 20890934)1, 4 Menezes R....Vieira A.R. (2010)
    7. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    8. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    9. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
    10. Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate. (PubMed id 18413325)1, 4 Chiquet B.T....Hecht J.T. (2008)

    External Searches for WNT5A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing WNT5A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7474 HGNC: 12784 AceView: WNT5A Ensembl:ENSG00000114251 euGenes: HUgn7474
    ECgene: WNT5A Kegg: 7474 H-InvDB: WNT5A

    Other Databases showing WNT5A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing WNT5A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WNT5A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT5A Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for WNT5A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for WNT5A gene:
    Search GeneIP for patents involving WNT5A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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