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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WNT4 Gene

protein-coding   GIFtS: 66
GCID: GC01M022443

Wingless-Type MMTV Integration Site Family, Member 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Wingless-Type MMTV Integration Site Family, Member 41 2
SERKAL2 5
WNT-42
Protein Wnt-42

External Ids:    HGNC: 127831   Entrez Gene: 543612   Ensembl: ENSG000001625527   OMIM: 6034905   UniProtKB: P567053   

Export aliases for WNT4 gene to outside databases

Previous GC identifers: GC01M022016 GC01M021481 GC01M021592 GC01M021915 GC01M022190 GC01M022318 GC01M020688


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WNT4 Gene:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These
proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell
fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first
signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino
acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the
testis-determining factor play a concerted role in both the control of female development and the prevention of
testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal
proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in
SERKAL syndrome. (provided by RefSeq, Jul 2008)

GeneCards Summary for WNT4 Gene: 
WNT4 (wingless-type MMTV integration site family, member 4) is a protein-coding gene. Diseases associated with WNT4 include eaf, and serkal syndrome, and among its related super-pathways are Wnt signaling pathway and Basal cell carcinoma. GO annotations related to this gene include transcription corepressor activity and G-protein coupled receptor binding. An important paralog of this gene is WNT5B.

UniProtKB/Swiss-Prot: WNT4_HUMAN, P56705
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental
protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to
signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation
in human breast tissue

Gene Wiki entry for WNT4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004610.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WNT4 gene promoter:
         AhR   Spz1   p53   FOXO3   MyoD   FOXO3b   HEN1   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWNT4 promoter sequence
   Search SABiosciences Chromatin IP Primers for WNT4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WNT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.23-p35.1   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.23-p35.1

WNT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M022443:  view genomic region     (about GC identifiers)

Start:
22,443,798 bp from pter      End:
22,470,462 bp from pter
Size:
26,665 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WNT4_HUMAN, P56705 (See protein sequence)
Recommended Name: Protein Wnt-4 precursor  
Size: 351 amino acids; 39052 Da
Subunit: Interacts with PORCN (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix
Secondary accessions: Q5TZQ0 Q96T81 Q9BXF5 Q9H1J8 Q9UJM2

Explore the universe of human proteins at neXtProt for WNT4: NX_P56705

Explore proteomics data for WNT4 at MOPED 

Post-translational modifications:

  • UniProtKB: Palmitoylation at Ser-212 is required for efficient binding to frizzled receptors. It is also required for
    subsequent palmitoylation at Cys-78. Palmitoylation is necessary for proper trafficking to cell surface (By
    similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P56705

  • WNT4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WNT4 Protein Expression
    REFSEQ proteins: NP_110388.2  
    ENSEMBL proteins: 
     ENSP00000290167   ENSP00000403334   ENSP00000388925   ENSP00000441033  
    Reactome Protein details: P56705
    Human Recombinant Protein Products for WNT4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for WNT4 (Wnt-4)
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for WNT4
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    Novus Biologicals WNT4 Protein
    Novus Biologicals WNT4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WNT4 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IDA16959810
    GO:0005737cytoplasm IDA16959810
    GO:0005788endoplasmic reticulum lumen TAS--

    WNT4 for ontologies           About GeneDecksing



    WNT4 Antibody Products: 
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    Cloud-Clone Corp. Antibodies for WNT4 
    ThermoFisher Antibodies for WNT4
    LSBio Antibodies in human, mouse, rat for WNT4 

    Assay Products for WNT4: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for WNT4
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    Cloud-Clone Corp. ELISAs for WNT4 
    Cloud-Clone Corp. CLIAs for WNT4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands
    WNT: Wingless-type MMTV integration sites

    3 InterPro protein domains:
     IPR009142 Wnt4
     IPR005817 Wnt
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry P56705

    ProtoNet protein and cluster: P56705

    1 Blocks protein domain: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WNT4_HUMAN, P56705
    Similarity: Belongs to the Wnt family


    WNT4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WNT4_HUMAN, P56705
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental
    protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to
    signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation
    in human breast tissue

         Summary:

    During embryonic development, WNT4 as signaling molecule is secreted from the following cells: Floor Plate Cells in Spinal Floor Plate, Interzone Cells in Autopod Synovial Joint (see all 5).

    It affects the following cells: Articular Cartilage Cells in Zeugopod Articular Cartilage, Articular Cartilage Cells in Autopod Articular Cartilage (see all 5).

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity ISS--
    GO:0005102receptor binding ----
    GO:0005109frizzled binding IBA--
    GO:0005201extracellular matrix structural constituent NAS--
    GO:0005515protein binding ----
         
    WNT4 for ontologies           About GeneDecksing


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 10 alleles(MGI details for Wnt4):
     embryogenesis  endocrine/exocrine gland  growth/size  hematopoietic system  immune system 
     integument  limbs/digits/tail  mortality/aging  nervous system  no phenotypic analysis 
     normal  renal/urinary system  reproductive system 

    WNT4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for WNT4: Wnt4tm1.2Boer Wnt4tm1Amc Wnt4tm1.2Bhr

       inGenious Targeting Laboratory - Custom generated mouse model solutions for WNT4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for WNT4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WNT4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WNT4 

    miRNA
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    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate WNT4 (see all 47):
    hsa-miR-194* hsa-miR-517a hsa-miR-15a hsa-miR-517c hsa-miR-503 hsa-miR-650 hsa-miR-29b-1* hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidWNT4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    GenScript: all cDNA clones in your preferred vector: WNT4 (NM_030761)
    Sino Biological Human cDNA Clone for WNT4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WNT4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT4
    Sirion Biotech Customized lentivirus for stable overexpression of WNT4 
                         Customized lentivirus expression plasmids for stable overexpression of WNT4 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for WNT4 About   (see all 19)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathway0.40
    2Basal cell carcinoma
    Hedgehog signaling pathway0.43
    Wnt Pathway0.39
    Basal cell carcinoma0.43
    Melanogenesis0.32
    3Wnt Signaling Pathway
    Wnt Signaling Pathway0.55
    DNA damage response (only ATM dependent)0.32
    Wnt Signaling Pathway and Pluripotency0.55
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    5Asparagine N-linked glycosylation
    WNT ligand biogenesis and trafficking0.77
    Signaling by Wnt0.62

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for WNT4
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    1 R&D Systems Pathway for WNT4
        Wnt Signaling Pathway

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for WNT4 (see all 7)
        GSK3 Signaling
    Presenilin-Mediated Signaling
    Colorectal Cancer Metastasis
    Human Embryonic Stem Cell Pluripotency
    Nanog in Mammalian ESC Pluripotency

    1 Tocris Bioscience Pathway for WNT4
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT4
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    4 BioSystems Pathways for WNT4
        Wnt Signaling Pathway
    DNA damage response (only ATM dependent)
    Wnt Signaling Pathway and Pluripotency
    Wnt Signaling Pathway NetPath

    2 Sino Biological Pathways for WNT4 
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    5/6        Reactome Pathways for WNT4 (see all 6)
        Signaling by Wnt
    Signal Transduction
    Signaling by GPCR
    WNT ligand biogenesis and trafficking
    GPCR ligand binding


    5/8         Kegg Pathways  (Kegg details for WNT4) (see all 8):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection


    WNT4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WNT4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/45 Interacting proteins for WNT4 (P567053 ENSP000002901674) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FZD1Q9UP383, ENSP000002879344I2D: score=2 STRING: ENSP00000287934
    FZD5Q134673, ENSP000003546074I2D: score=2 STRING: ENSP00000354607
    FZD6O603533, ENSP000003516054I2D: score=2 STRING: ENSP00000351605
    PTENP604843, ENSP000003610214I2D: score=1 STRING: ENSP00000361021
    PORCNQ9H2373, ENSP000003223044I2D: score=5 STRING: ENSP00000322304
    About this table

    Gene Ontology (GO): 5/70 biological process terms (GO ID links to tree view) (see all 70):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001656metanephros development ----
    GO:0001658branching involved in ureteric bud morphogenesis IEA--
    GO:0001822kidney development IEP15312687
    GO:0001823mesonephros development ----
    GO:0001837epithelial to mesenchymal transition IEP12841867

    WNT4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    WNT4 for compounds           About GeneDecksing

    EMD Millipore small molecules for WNT4:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WNT4

    2 Novoseek inferred chemical compound relationships for WNT4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    testosterone 13.4 2 15317892 (1), 12949260 (1)
    progesterone 6.8 2 17711857 (1), 12949260 (1)

    Search CenterWatch for drugs/clinical trials and news about WNT4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WNT4 gene: 
    NM_030761.4  

    Unigene Cluster for WNT4:

    Wingless-type MMTV integration site family, member 4
    Hs.25766  [show with all ESTs]
    Unigene Representative Sequence: NM_030761
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000290167(uc001bfs.4) ENST00000415567 ENST00000441048 ENST00000542383(uc010odt.2)

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    SwitchGear 3'UTR luciferase reporter plasmidWNT4 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WNT4
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WNT4

    Additional mRNA sequence: 

    AB061675.1 AF316543.1 AK296058.1 AY009398.1 AY358947.1 BC007386.2 BC057781.1 BT020125.1 

    3 DOTS entries:

    DT.70104953  DT.70105154  DT.97800841 

    24/50 AceView cDNA sequences (see all 50):

    AI139742 CK821662 BQ269212 AF316543 NM_030761 BE218554 BM128213 CK821661 
    BC057781 AI634496 AW137060 BQ268938 AI267902 BE549894 BM894135 AY009398 
    BQ270857 BM544112 AI871742 BF448386 BM977073 BX115343 AB061675 AA934393 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WNT4 expression in normal human tissues (normalized intensities)      WNT4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAACAAGACG
    WNT4 Expression
    About this image


    WNT4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/36 selected tissues (see all 36) fully expand
     
     Kidney (Urinary System)    fully expand to see all 17 entries
             Pretubular Aggregate Cells Pretubular Aggregates
             Metanephros
             mK3
             Renal-like cells ( Derivation of renal-like cells from mouse embryonic stem cells...
             kidney ; cells in tubules   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 7 entries
             Articular Cartilage Cells Zeugopod Articular Cartilage
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             Brain Pericytes   
             brain/hindbrain   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 4 entries
             Ureter
             visceral organ   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             mouse/organ system/cardiovascular system   

    See WNT4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WNT4

    SOURCE GeneReport for Unigene cluster: Hs.25766
        SABiosciences Expression via Pathway-Focused PCR Arrays including WNT4: 
              Notch Signaling Targets in human mouse rat
              Estrogen Receptor Signaling in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WNT4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for WNT4 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wnt41 , 5 wingless-related MMTV integration site 41, 5 90.22(n)1
    98.86(a)1
      4 (69.80 cM)5
    224171  NM_009523.21  NP_033549.11 
     1372774895 
    chicken
    (Gallus gallus)
    Aves WNT41 wingless-type MMTV integration site family, member more 81.2(n)
    85.47(a)
      395561  NM_204783.1  NP_990114.1 
    lizard
    (Anolis carolinensis)
    Reptilia WNT46
    Protein Wnt
    87(a)
    1 ↔ 1
    AAWZ02037479(10792-12989)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xwnt-42 (Xwnt-4) 77.18(n)    U13183.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wnt4a2 wnt4a 80.56(n)   30123  U25141.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cwn-11 , 3 Expression: embryo, L1 larva, L2 larva,
    L3 larva, more3
    Protein CWN-11
    46(a)
    (best of 5)3
    50.64(n)1
    46.88(a)1
      II(131165-133577)3
    1733991  NM_061267.31  NP_493668.11 


    ENSEMBL Gene Tree for WNT4 (if available)
    TreeFam Gene Tree for WNT4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WNT4 gene
    WNT5B2  WNT162  WNT62  WNT5A2  WNT112  WNT22  WNT2B2  WNT3A2  
    WNT12  WNT10B2  WNT7A2  WNT7B2  WNT32  WNT10A2  
    18 SIMAP similar genes for WNT4 using alignment to 5 protein entries:     WNT4_HUMAN (see all proteins):
    WNT2    WNT2B    WNT3A    WNT3    WNT7A    WNT5A
    WNT7B    WNT16    WNT5B    WNT11    WNT10B    WNT1
    WNT9B    WNT9A    WNT6    WNT8B    WNT8A    WNT10A

    WNT4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/552 SNPs in WNT4 are shown (see all 552)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0434984
    Rokitansky-Kuster-Hauser syndrome (RKH syndrome)4--see VAR_0434982 R C mis40--------
    VAR_0434974
    Rokitansky-Kuster-Hauser syndrome (RKH syndrome)4--see VAR_0434972 L P mis40--------
    VAR_0434994
    46,XX sex reversal with dysgenesis of kidneys, adrenals, and lungs (SERKAL)4--see VAR_0434992 A V mis40--------
    VAR_0347034
    Rokitansky-Kuster-Hauser syndrome (RKH syndrome)4--see VAR_0347032 E G mis40--------
    rs124064951,2
    H--22443465(+) AGAAAA/CTAAGT 1 -- ds50010--------
    rs728792911,2
    C,F--22443482(+) CCCTCA/TTCCCC 1 -- ds50014Minor allele frequency- T:0.11WA CSA NA 242
    rs1447424301,2
    --22443587(+) AGCTGA/GTCATG 1 -- ds50010--------
    rs22355301,2
    C,F,H--22443760(-) GAAGAG/AACTTG 1 -- ds500117Minor allele frequency- A:0.12EA NS NA CSA 3416
    rs1143733491,2
    F--22443763(+) GTCTCT/GTCTCC 1 -- ds50011Minor allele frequency- G:0.02WA 118
    rs1481065701,2
    C--22443796(+) GTCACA/GATTGC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for WNT4 (22443798 - 22470462 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for WNT4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv6076CNV Insertion18451855
    nsv460806CNV Loss19166990
    nsv871778CNV Gain21882294


    Human Gene Mutation Database (HGMD): WNT4
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing WNT4
    DNA2.0 Custom Variant and Variant Library Synthesis for WNT4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603490   
    OMIM disorders: 611812  158330  
    UniProtKB/Swiss-Prot: WNT4_HUMAN, P56705
  • Rokitansky-Kuster-Hauser syndrome (RKH syndrome) [MIM:277000]: Characterized by utero-vaginal atresia in
    otherwise phenotypically normal female with a normal 46,XX karyotype. Anomalies of the genital tract range from
    upper vaginal atresia to total Muellerian agenesis with urinary tract abnormalities. It has an incidence of
    approximately 1 in 5'000 newborn girls. Note=The disease is caused by mutations affecting the gene represented in
    this entry
  • 46,XX sex reversal with dysgenesis of kidneys, adrenals, and lungs (SERKAL) [MIM:611812]: A disease
    characterized by the association of female-to-male sex reversal with dysgenesis of kidneys, adrenals, and lungs.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Mullerian aplasia and hyperandrogenism (MULLAPL) [MIM:158330]: A disorder of sex development. Affected
    females manifest dysgenesis of Mullerian duct derivatives absent or rudimentary uterus and vagina, functional
    ovaries, primary amenorrhea, hyperandrogenism and hirsutism. Note=The disease is caused by mutations affecting
    the gene represented in this entry

  • 20/30 diseases for WNT4 (see all 30):    About MalaCards
    eaf    serkal syndrome    vaginal atresia    wnt4-related 46,xy dsd and 46,xy cgd
    mullerian aplasia and hyperandrogenism    mayer-rokitansky-kuster-hauser syndrome    mullerian aplasia    hermaphroditism
    disorders of sex development    46, xy disorders of sex development    hyperandrogenism    gonadal dysgenesis
    amenorrhea    premature ovarian failure    basal cell carcinoma    polycystic ovary syndrome
    pituitary adenoma    vaginitis    endometriosis    endometrial carcinoma


    WNT4 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for WNT4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virilization 60.8 4 15317892 (1), 15988165 (1), 15581876 (1), 11283799 (1)
    tumors 6.47 1 8168088 (1)
    breast cancer 0 1 16501043 (1)

    GeneTests: WNT4
    GeneReviews: WNT4
    Genetic Association Database (GAD): WNT4
    Human Genome Epidemiology (HuGE) Navigator: WNT4 (4 documents)

    Export disorders for WNT4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WNT4 gene, integrated from 9 sources (see all 127):
    (articles sorted by number of sources associating them with WNT4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. (PubMed id 8168088)1, 2, 3, 9 Huguet E.L.... Harris A.L. (1994)
    2. WNT4 deficiency-a clinical phenotype distinct from the classic Mayer- Rokitansky-Kuster-Hauser syndrome: a case report. (PubMed id 16959810)1, 2, 9 Biason-Lauber A....Schoenle E.J. (2007)
    3. A WNT4 mutation associated with Muellerian-duct regression and virilization in a 46,XX woman. (PubMed id 15317892)1, 2, 9 Biason-Lauber A.... Schoenle E.J. (2004)
    4. Up-regulation of wnt-4 signaling and dosage-sensitive sex reversal in humans. (PubMed id 11283799)1, 2, 9 Jordan B.K.... Vilain E. (2001)
    5. Wnt signaling and Dupuytren's disease. (PubMed id 21732829)1, 4 Dolmans G.H.... . (2011)
    6. A genome-wide association study identifies genetic va riants in the CDKN2BAS locus associated with endometriosis in Japanese. (PubMed id 20601957)1, 4 Uno S....Nakamura Y. (2010)
    7. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    8. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
    9. Identification and functional analysis of a new WNT4 gene mutation among 28 adolescent girls with primary amenorrhea and Muellerian duct abnormalities: a French collaborative study. (PubMed id 18182450)1, 2 Philibert P.... Sultan C. (2008)
    10. SERKAL syndrome: an autosomal-recessive disorder caused by a loss-of- function mutation in WNT4. (PubMed id 18179883)1, 2 Mandel H....Sprecher E. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54361 HGNC: 12783 AceView: WNT4 Ensembl:ENSG00000162552 euGenes: HUgn54361
    ECgene: WNT4 Kegg: 54361 H-InvDB: WNT4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WNT4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT4 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/WNT4

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WNT4 gene:
    Search GeneIP for patents involving WNT4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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