Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



WNT4 Gene

protein-coding   GIFtS: 67
GCID: GC01M022443

Wingless-Type MMTV Integration Site Family, Member 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Wingless-Type MMTV Integration Site Family, Member 41 2
SERKAL2 5
WNT-42
Protein Wnt-42

External Ids:    HGNC: 127831   Entrez Gene: 543612   Ensembl: ENSG000001625527   OMIM: 6034905   UniProtKB: P567053   

Export aliases for WNT4 gene to outside databases

Previous GC identifers: GC01M022016 GC01M021481 GC01M021592 GC01M021915 GC01M022190 GC01M022318 GC01M020688


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for WNT4 Gene:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These
proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell
fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first
signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino
acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the
testis-determining factor play a concerted role in both the control of female development and the prevention of
testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal
proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in
SERKAL syndrome. (provided by RefSeq, Jul 2008)

GeneCards Summary for WNT4 Gene:
WNT4 (wingless-type MMTV integration site family, member 4) is a protein-coding gene. Diseases associated with WNT4 include vaginal atresia, and mullerian aplasia. GO annotations related to this gene include transcription corepressor activity and frizzled binding. An important paralog of this gene is WNT5B.

UniProtKB/Swiss-Prot: WNT4_HUMAN, P56705
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental
protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to
signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation
in human breast tissue

Gene Wiki entry for WNT4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WNT4 gene promoter:
         AhR   Spz1   p53   FOXO3   MyoD   FOXO3b   HEN1   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWNT4 promoter sequence
   Search Chromatin IP Primers for WNT4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WNT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.23-p35.1   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.23-p35.1

WNT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M022443:  view genomic region     (about GC identifiers)

Start:
22,443,798 bp from pter      End:
22,470,462 bp from pter
Size:
26,665 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: WNT4_HUMAN, P56705 (See protein sequence)
Recommended Name: Protein Wnt-4 precursor  
Size: 351 amino acids; 39052 Da
Subunit: Interacts with PORCN (By similarity)
Secondary accessions: Q5TZQ0 Q96T81 Q9BXF5 Q9H1J8 Q9UJM2

Explore the universe of human proteins at neXtProt for WNT4: NX_P56705

Explore proteomics data for WNT4 at MOPED

Post-translational modifications: 

  • Palmitoylation at Ser-212 is required for efficient binding to frizzled receptors. It is also required for
    subsequent palmitoylation at Cys-78. Palmitoylation is necessary for proper trafficking to cell surface (By
    similarity)1
  • Glycosylation2 at Asn88, Asn297
  • Modification sites at PhosphoSitePlus

  • See WNT4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_110388.2  
    ENSEMBL proteins: 
     ENSP00000290167   ENSP00000403334   ENSP00000388925   ENSP00000441033  
    Reactome Protein details: P56705

    WNT4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for WNT4 (Wnt-4)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for WNT4
    OriGene Custom MassSpec
    OriGene Custom Protein Services for WNT4
    GenScript Custom Purified and Recombinant Proteins Services for WNT4
    Novus Biologicals WNT4 Protein
    Novus Biologicals WNT4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WNT4

    WNT4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of WNT4
    R&D Systems Antibodies for WNT4 (Wnt-4)
    OriGene Antibodies for WNT4
    OriGene Custom Antibody Services for WNT4
    Novus Biologicals WNT4 Antibodies
    Abcam antibodies for WNT4
    Cloud-Clone Corp. Antibodies for WNT4
    ThermoFisher Antibodies for WNT4
    LSBio Antibodies in human, mouse, rat for WNT4

    WNT4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for WNT4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for WNT4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for WNT4
    Cloud-Clone Corp. CLIAs for WNT4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    WNT: Wingless-type MMTV integration sites

    3 InterPro protein domains:
     IPR009142 Wnt4
     IPR005817 Wnt
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry P56705

    ProtoNet protein and cluster: P56705

    1 Blocks protein domain: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WNT4_HUMAN, P56705
    Similarity: Belongs to the Wnt family


    WNT4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WNT4_HUMAN, P56705
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental
    protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to
    signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation
    in human breast tissue

         Summary: 

    During embryonic development, WNT4 as signaling molecule is secreted from the following cells:
          selected tissues (see all 3)      fully expand
    Limb: Interzone Cells (Stylopod Synovial Joint), Interzone Cells (Autopod Synovial Joint)      fully expand to see all 3 cells
    Neural Tube: Floor Plate Cells (Spinal Floor Plate)

    It affects the following cells:
          selected tissues (see all 3)      fully expand
    Cartilage: Articular Cartilage Cells (Autopod Articular Cartilage), Articular Cartilage Cells (Zeugopod Articular Cartilage)      fully expand to see all 3 cells
    Kidney: Pretubular Aggregate Cells (Pretubular Aggregates)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity ISS--
    GO:0005102receptor binding ----
    GO:0005109frizzled binding IBA--
    GO:0005201extracellular matrix structural constituent ----
    GO:0005515protein binding ----
         
    WNT4 for ontologies           About GeneDecksing


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 11 alleles(MGI details for Wnt4):
     embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system  immune system 
     integument  limbs/digits/tail  mortality/aging  nervous system  no phenotypic analysis 
     normal  renal/urinary system  reproductive system 

    WNT4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for WNT4: Wnt4tm1.2Boer Wnt4tm1Amc Wnt4tm1.2Bhr

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WNT4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for WNT4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WNT4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WNT4

    miRNA
    Products:
        
    miRTarBase miRNAs that target WNT4:
    hsa-mir-29c-3p (MIRT006385)

    Block miRNA regulation of human, mouse, rat WNT4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WNT4 (see all 47):
    hsa-miR-194* hsa-miR-517a hsa-miR-15a hsa-miR-517c hsa-miR-503 hsa-miR-650 hsa-miR-29b-1* hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidWNT4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for WNT4
    Predesigned siRNA for gene silencing in human, mouse, rat WNT4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for WNT4

    Clone
    Products:
         
    OriGene clones in human, mouse for WNT4 (see all 6)
    OriGene ORF clones in mouse, rat for WNT4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WNT4 (NM_030761)
    Sino Biological Human cDNA Clone for WNT4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WNT4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for WNT4
    Browse ESI BIO Cell Lines and PureStem Progenitors for WNT4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    WNT4_HUMAN, P56705: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    golgi apparatus3
    plasma membrane3
    lysosome1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IDA16959810
    GO:0005737cytoplasm IDA16959810
    GO:0005788endoplasmic reticulum lumen TAS--

    WNT4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for WNT4 About   (see all 22)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathways0.40
    2Wnt Pathway
    Wnt Pathway0.56
    WNT ligand biogenesis and trafficking0.56
    3Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway0.55
    DNA damage response (only ATM dependent)0.32
    Wnt Signaling Pathway and Pluripotency0.55
    4Basal cell carcinoma
    Basal cell carcinoma0.43
    Melanogenesis0.32
    Hedgehog signaling pathway0.43
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for WNT4
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for WNT4 (see all 7)
        GSK3 Signaling
    Presenilin-Mediated Signaling
    Colorectal Cancer Metastasis
    Human Embryonic Stem Cell Pluripotency
    Nanog in Mammalian ESC Pluripotency

    1 Tocris Bioscience Pathway for WNT4
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT4
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    4 BioSystems Pathways for WNT4
        Wnt Signaling Pathway
    DNA damage response (only ATM dependent)
    Wnt Signaling Pathway and Pluripotency
    Wnt Signaling Pathway NetPath

    2 Sino Biological Pathways for WNT4
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    4 Reactome Pathways for WNT4
        PCP/CE pathway
    WNT ligand biogenesis and trafficking
    negative regulation of TCF-dependent signaling by WNT ligand antagonists
    Class B/2 (Secretin family receptors)


    Selected Kegg Pathways  (Kegg details for WNT4) (see all 9):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Hippo signaling pathway
    Melanogenesis
    Thyroid hormone signaling pathway


    WNT4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT4: 
              Notch Signaling Targets in human mouse rat
              Estrogen Receptor Signaling in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for WNT4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WNT4 (P567053 ENSP000002901674) via UniProtKB, MINT, STRING, and/or I2D (see all 97)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FZD1Q9UP383, ENSP000002879344I2D: score=2 STRING: ENSP00000287934
    FZD5Q134673, ENSP000003546074I2D: score=2 STRING: ENSP00000354607
    FZD6O603533, ENSP000003516054I2D: score=2 STRING: ENSP00000351605
    NOTCH2Q047213, ENSP000002566464I2D: score=2 STRING: ENSP00000256646
    BMP4P126443, ENSP000002454514I2D: score=1 STRING: ENSP00000245451
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 72):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001656metanephros development ----
    GO:0001658branching involved in ureteric bud morphogenesis IEA--
    GO:0001822kidney development IEP15312687
    GO:0001823mesonephros development ----
    GO:0001837epithelial to mesenchymal transition IEP12841867

    WNT4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WNT4

    2 Novoseek inferred chemical compound relationships for WNT4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    testosterone 13.4 2 15317892 (1), 12949260 (1)
    progesterone 6.8 2 17711857 (1), 12949260 (1)



    WNT4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for WNT4 gene: 
    NM_030761.4  

    Unigene Cluster for WNT4:

    Wingless-type MMTV integration site family, member 4
    Hs.25766  [show with all ESTs]
    Unigene Representative Sequence: NM_030761
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000290167(uc001bfs.4) ENST00000415567 ENST00000441048 ENST00000542383(uc010odt.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat WNT4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WNT4 (see all 47):
    hsa-miR-194* hsa-miR-517a hsa-miR-15a hsa-miR-517c hsa-miR-503 hsa-miR-650 hsa-miR-29b-1* hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidWNT4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for WNT4
    Predesigned siRNA for gene silencing in human, mouse, rat WNT4
    Clone
    Products:
         
    OriGene clones in human, mouse for WNT4 (see all 6)
    OriGene ORF clones in mouse, rat for WNT4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WNT4 (NM_030761)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WNT4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for WNT4
    OriGene qSTAR qPCR primer pairs in human, mouse for WNT4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WNT4
      QuantiTect SYBR Green Assays in human, mouse, rat WNT4
      QuantiFast Probe-based Assays in human, mouse, rat WNT4

    Additional mRNA sequence: 

    AB061675.1 AF316543.1 AK296058.1 AY009398.1 AY358947.1 BC007386.2 BC057781.1 BT020125.1 

    3 DOTS entries:

    DT.70104953  DT.70105154  DT.97800841 

    Selected AceView cDNA sequences (see all 50):

    BC057781 AW137060 CK821661 BM128213 AI139742 AI634496 BQ269212 NM_030761 
    CK821662 AF316543 BE218554 BQ268938 BQ270857 BM894135 BE670299 BM544112 
    AB061675 AI632967 AY358947 BU947973 AI924610 AA934393 AI871742 BM977073 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    WNT4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAACAAGACG
    WNT4 Expression
    About this image


    WNT4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Kidney (Urinary System)    fully expand to see all 15 entries
             Pretubular Aggregate Cells Pretubular Aggregates
             Metanephros
             mK4
             Renal-like cells
     
     Epithelial Cells
             Intermediate Keratinocytes Embryonic Epidermis
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Ovarian Somatic Cells Ovigerous Cord
             Oviduct
             Secondary follicles
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             Articular Cartilage Cells Zeugopod Articular Cartilage
     
     Tooth (Integumentary System)    fully expand to see all 4 entries
             Inner Enamel Epithelial Cells Dental Enamel
    WNT4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WNT4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.25766
        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT4: 
              Notch Signaling Targets in human mouse rat
              Estrogen Receptor Signaling in human mouse rat
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for WNT4
    OriGene qSTAR qPCR primer pairs in human, mouse for WNT4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WNT4
    QuantiTect SYBR Green Assays in human, mouse, rat WNT4
    QuantiFast Probe-based Assays in human, mouse, rat WNT4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for WNT4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wnt41 , 5 wingless-related MMTV integration site 41, 5 90.22(n)1
    98.86(a)1
      4 (69.80 cM)5
    224171  NM_009523.21  NP_033549.11 
     1372774895 
    chicken
    (Gallus gallus)
    Aves WNT41 wingless-type MMTV integration site family, member more 81.2(n)
    85.47(a)
      395561  NM_204783.1  NP_990114.1 
    lizard
    (Anolis carolinensis)
    Reptilia WNT46
    wingless-type MMTV integration site family, member...
    87(a)
    1 ↔ 1
    AAWZ02037479(10792-12989)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xwnt-42 (Xwnt-4) 77.18(n)    U13183.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wnt4a2 wnt4a 80.56(n)   30123  U25141.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Wnt51 , 3 Wnt receptor signaling pathway signal
    transducer3
    Wnt oncogene analog 51
    45(a)
    (best of 2)3
    52.97(n)1
    44.17(a)1
      328381  NM_057576.41  NP_476924.11 
    worm
    (Caenorhabditis elegans)
    Secernentea cwn-11 , 3 Expression: embryo, L1 larva, L2 larva,
    L3 larva, more3
    cwn-11
    46(a)
    (best of 5)3
    50.54(n)1
    47.18(a)1
      II(131165-133577)3
    1733991  NM_061267.41  NP_493668.11 


    ENSEMBL Gene Tree for WNT4 (if available)
    TreeFam Gene Tree for WNT4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for WNT4 gene
    WNT5B2  WNT162  WNT62  WNT5A2  WNT112  WNT22  WNT2B2  WNT3A2  
    WNT12  WNT7A2  WNT7B2  WNT32  
    18 SIMAP similar genes for WNT4 using alignment to 5 protein entries:     WNT4_HUMAN (see all proteins):
    WNT2    WNT2B    WNT3A    WNT3    WNT11    WNT7A
    WNT5A    WNT7B    WNT16    WNT5B    WNT10B    WNT1
    WNT9B    WNT9A    WNT6    WNT8B    WNT8A    WNT10A

    WNT4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for WNT4 (see all 552)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0434984
    Rokitansky-Kuster-Hauser syndrome (RKH syndrome)4--see VAR_0434982 R C mis40--------
    VAR_0434974
    Rokitansky-Kuster-Hauser syndrome (RKH syndrome)4--see VAR_0434972 L P mis40--------
    VAR_0434994
    46,XX sex reversal with dysgenesis of kidneys, adrenals, and lungs (SERKAL)4--see VAR_0434992 A V mis40--------
    VAR_0347034
    Rokitansky-Kuster-Hauser syndrome (RKH syndrome)4--see VAR_0347032 E G mis40--------
    rs124064951,2
    H--22443465(+) AGAAAA/CTAAGT 1 -- ds50010--------
    rs728792911,2
    C,F--22443482(+) CCCTCA/TTCCCC 1 -- ds50014Minor allele frequency- T:0.11WA CSA NA 242
    rs1447424301,2
    --22443587(+) AGCTGA/GTCATG 1 -- ds50010--------
    rs22355301,2
    C,F,H--22443760(-) GAAGAG/AACTTG 1 -- ds500117Minor allele frequency- A:0.12EA NS NA CSA 3416
    rs1143733491,2
    F--22443763(+) GTCTCT/GTCTCC 1 -- ds50011Minor allele frequency- G:0.02WA 118
    rs1481065701,2
    C--22443796(+) GTCACA/GATTGC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for WNT4 (22443798 - 22470462 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for WNT4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6076CNV Insertion18451855
    nsv460806CNV Loss19166990
    nsv871778CNV Gain21882294

    Human Gene Mutation Database (HGMD): WNT4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WNT4
    DNA2.0 Custom Variant and Variant Library Synthesis for WNT4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603490   
    OMIM disorders: 611812  158330  
    UniProtKB/Swiss-Prot: WNT4_HUMAN, P56705
  • Rokitansky-Kuster-Hauser syndrome (RKH syndrome) [MIM:277000]: Characterized by utero-vaginal atresia in
    otherwise phenotypically normal female with a normal 46,XX karyotype. Anomalies of the genital tract range from
    upper vaginal atresia to total Muellerian agenesis with urinary tract abnormalities. It has an incidence of
    approximately 1 in 5'000 newborn girls. Note=The disease is caused by mutations affecting the gene represented in
    this entry
  • 46,XX sex reversal with dysgenesis of kidneys, adrenals, and lungs (SERKAL) [MIM:611812]: A disease
    characterized by the association of female-to-male sex reversal with dysgenesis of kidneys, adrenals, and lungs.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Mullerian aplasia and hyperandrogenism (MULLAPL) [MIM:158330]: A disorder of sex development. Affected
    females manifest dysgenesis of Mullerian duct derivatives absent or rudimentary uterus and vagina, functional
    ovaries, primary amenorrhea, hyperandrogenism and hirsutism. Note=The disease is caused by mutations affecting
    the gene represented in this entry

  • Selected diseases for WNT4 (see all 39):    
    About MalaCards
    vaginal atresia    mullerian aplasia    wnt4-related 46,xy dsd and 46,xy cgd    mullerian aplasia and hyperandrogenism
    serkal syndrome    mayer-rokitansky-kuster-hauser syndrome    eaf    vaginitis
    dosage-sensitive sex reversal    hermaphroditism    hyperandrogenism    gonadal dysgenesis
    amenorrhea    premature ovarian failure    basal cell carcinoma    polycystic ovary syndrome
    pituitary adenoma    endometriosis    labyrinthitis    endometrial carcinoma


    WNT4 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for WNT4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virilization 60.8 4 15317892 (1), 15988165 (1), 15581876 (1), 11283799 (1)
    tumors 6.47 1 8168088 (1)
    breast cancer 0 1 16501043 (1)

    GeneTests: WNT4
    GeneReviews: WNT4
    Genetic Association Database (GAD): WNT4
    Human Genome Epidemiology (HuGE) Navigator: WNT4 (4 documents)

    Export disorders for WNT4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for WNT4 gene, integrated from 10 sources (see all 129):
    (articles sorted by number of sources associating them with WNT4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. (PubMed id 8168088)1, 2, 3, 9 Huguet E.L.... Harris A.L. (Cancer Res. 1994)
    2. WNT4 deficiency-a clinical phenotype distinct from the classic Mayer- Rokitansky-Kuster-Hauser syndrome: a case report. (PubMed id 16959810)1, 2, 9 Biason-Lauber A....Schoenle E.J. (Hum. Reprod. 2007)
    3. A WNT4 mutation associated with Muellerian-duct regression and virilization in a 46,XX woman. (PubMed id 15317892)1, 2, 9 Biason-Lauber A.... Schoenle E.J. (N. Engl. J. Med. 2004)
    4. Up-regulation of wnt-4 signaling and dosage-sensitive sex reversal in humans. (PubMed id 11283799)1, 2, 9 Jordan B.K.... Vilain E. (Am. J. Hum. Genet. 2001)
    5. Wnt signaling and Dupuytren's disease. (PubMed id 21732829)1, 4 Dolmans G.H.... . (N. Engl. J. Med. 2011)
    6. A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese. (PubMed id 20601957)1, 4 Uno S....Nakamura Y. (Nat. Genet. 2010)
    7. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    8. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    9. Identification and functional analysis of a new WNT4 gene mutation among 28 adolescent girls with primary amenorrhea and Muellerian duct abnormalities: a French collaborative study. (PubMed id 18182450)1, 2 Philibert P.... Sultan C. (J. Clin. Endocrinol. Metab. 2008)
    10. SERKAL syndrome: an autosomal-recessive disorder caused by a loss-of- function mutation in WNT4. (PubMed id 18179883)1, 2 Mandel H....Sprecher E. (Am. J. Hum. Genet. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 54361 HGNC: 12783 AceView: WNT4 Ensembl:ENSG00000162552 euGenes: HUgn54361
    ECgene: WNT4 Kegg: 54361 H-InvDB: WNT4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for WNT4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT4 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=WNT4[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for WNT4 gene:
    Search GeneIP for patents involving WNT4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of WNT4
     
     EMD Millipore genomic analysis products

      
     Antibodies for WNT4 (Wnt-4)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for WNT4 (Wnt-4)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for WNT4   OriGene RNAi products in human, mouse, rat for WNT4  
     OriGene qPCR primer pairs and template standards for WNT4   OriGene Protein Over-expression Lysate for WNT4  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for WNT4  
     OriGene qSTAR qPCR primer pairs in human, mouse for WNT4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for WNT4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for WNT4   OriGene Custom Protein Services for WNT4  

     
     
     Block miRNA regulation of human, mouse, rat WNT4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing WNT4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WNT4 Predesigned siRNA for gene silencing in human, mouse, rat WNT4
     QuantiFast Probe-based Assays in human, mouse, rat WNT4 QuantiTect SYBR Green Assays in human, mouse, rat WNT4
     PCR Arrays including human, mouse, rat WNT4 Search Chromatin IP Primers for WNT4
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WNT4  GeneGlobe Interaction Network for WNT4
     Regulatory tfbs in WNT4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for WNT4 GenScript cDNA clones with any tag delivered in your preferred vector for WNT4
     GenScript Custom Assay Services for WNT4 GenScript Custom overexpressing Cell Line Services for WNT4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for WNT4
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for WNT4
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     WNT4 antibodies
     WNT4 proteins
     WNT4 lysates
     Antibodies for WNT4
     See all of Abcam's Antibodies, Kits and Proteins for WNT4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for WNT4
     Antibodies for WNT4
     ELISAs for WNT4
     CLIAs for WNT4



     Browse ESI BIO Cell Lines and PureStem Progenitors for WNT4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT4
     SwitchGear 3'UTR luciferase reporter plasmids for WNT4
     SwitchGear Promoter luciferase reporter plasmids for WNT4
     ThermoFisher Antibodies for WNT4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WNT4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for WNT4
     LSBio Antibodies in human, mouse, rat for WNT4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      WNT4 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4