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Aliases for WNT4 Gene

Aliases for WNT4 Gene

  • Wnt Family Member 4 2 3
  • Wingless-Type MMTV Integration Site Family, Member 4 2 3
  • Wingless-Type MMTV Integration Site Family Member 4 3 5
  • SERKAL 3
  • WNT-4 3

External Ids for WNT4 Gene

Previous GeneCards Identifiers for WNT4 Gene

  • GC01M022016
  • GC01M021481
  • GC01M021592
  • GC01M021915
  • GC01M022318
  • GC01M022443
  • GC01M020688

Summaries for WNT4 Gene

Entrez Gene Summary for WNT4 Gene

  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT4 Gene

WNT4 (Wnt Family Member 4) is a Protein Coding gene. Diseases associated with WNT4 include serkal syndrome and mullerian aplasia and hyperandrogenism. Among its related pathways are Signaling by GPCR and Wnt Signaling Pathway (WikiPathways). GO annotations related to this gene include receptor binding and frizzled binding. An important paralog of this gene is WNT5B.

UniProtKB/Swiss-Prot for WNT4 Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation in human breast tissue.

Gene Wiki entry for WNT4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT4 Gene

Genomics for WNT4 Gene

Regulatory Elements for WNT4 Gene

Promoters for WNT4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WNT4 on UCSC Golden Path with GeneCards custom track

Genomic Location for WNT4 Gene

Chromosome:
1
Start:
22,117,305 bp from pter
End:
22,143,981 bp from pter
Size:
26,677 bases
Orientation:
Minus strand

Genomic View for WNT4 Gene

Genes around WNT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT4 Gene

Proteins for WNT4 Gene

  • Protein details for WNT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56705-WNT4_HUMAN
    Recommended name:
    Protein Wnt-4
    Protein Accession:
    P56705
    Secondary Accessions:
    • B4DJF9
    • Q5TZQ0
    • Q96T81
    • Q9BXF5
    • Q9H1J8
    • Q9UJM2

    Protein attributes for WNT4 Gene

    Size:
    351 amino acids
    Molecular mass:
    39052 Da
    Quaternary structure:
    • Interacts with PORCN.

    Alternative splice isoforms for WNT4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WNT4 Gene

Proteomics data for WNT4 Gene at MOPED

Post-translational modifications for WNT4 Gene

  • Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at Asn 88 and Asn 297
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for WNT4 Gene

Domains & Families for WNT4 Gene

Gene Families for WNT4 Gene

Protein Domains for WNT4 Gene

Suggested Antigen Peptide Sequences for WNT4 Gene

Graphical View of Domain Structure for InterPro Entry

P56705

UniProtKB/Swiss-Prot:

WNT4_HUMAN :
  • Belongs to the Wnt family.
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT4: view

Function for WNT4 Gene

Molecular function for WNT4 Gene

UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation in human breast tissue.
genes like me logo Genes that share phenotypes with WNT4: view

Human Phenotype Ontology for WNT4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for WNT4 Gene

MGI Knock Outs for WNT4:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for WNT4 Gene

Localization for WNT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT4 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WNT4 Gene COMPARTMENTS Subcellular localization image for WNT4 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 4
golgi apparatus 4
nucleus 2
cytoskeleton 1
lysosome 1
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for WNT4 Gene

Pathways & Interactions for WNT4 Gene

genes like me logo Genes that share pathways with WNT4: view

SIGNOR curated interactions for WNT4 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for WNT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEP 15312687
GO:0001823 mesonephros development IEA --
GO:0001837 epithelial to mesenchymal transition IEP 12841867
GO:0001838 embryonic epithelial tube formation IEA --
GO:0001889 liver development IEP 15312687
genes like me logo Genes that share ontologies with WNT4: view

Drugs & Compounds for WNT4 Gene

(2) Drugs for WNT4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with WNT4: view

Transcripts for WNT4 Gene

Unigene Clusters for WNT4 Gene

Wingless-type MMTV integration site family, member 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WNT4 Gene

No ASD Table

Relevant External Links for WNT4 Gene

GeneLoc Exon Structure for
WNT4
ECgene alternative splicing isoforms for
WNT4

Expression for WNT4 Gene

mRNA expression in normal human tissues for WNT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT4 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x7.6), Ovary (x6.3), and Skin - Sun Exposed (Lower leg) (x6.2).

Protein differential expression in normal tissues from HIPED for WNT4 Gene

This gene is overexpressed in Prostate (27.5), Testis (11.4), Islet of Langerhans (10.5), Ovary (6.7), and Peripheral blood mononuclear cells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WNT4 Gene



SOURCE GeneReport for Unigene cluster for WNT4 Gene Hs.25766

genes like me logo Genes that share expression patterns with WNT4: view

Protein tissue co-expression partners for WNT4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for WNT4 Gene

Orthologs for WNT4 Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WNT4 35
  • 91.95 (n)
  • 90.23 (a)
WNT4 36
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WNT4 36
  • 100 (a)
OneToOne
WNT4 35
  • 92.72 (n)
  • 99.69 (a)
dog
(Canis familiaris)
Mammalia WNT4 35
  • 94.36 (n)
  • 100 (a)
WNT4 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wnt4 36
  • 99 (a)
OneToOne
Wnt4 16
Wnt4 35
  • 90.22 (n)
  • 98.86 (a)
oppossum
(Monodelphis domestica)
Mammalia WNT4 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WNT4 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wnt4 35
  • 90.5 (n)
  • 98.29 (a)
chicken
(Gallus gallus)
Aves WNT4 36
  • 85 (a)
OneToOne
WNT4 35
  • 81.2 (n)
  • 85.47 (a)
lizard
(Anolis carolinensis)
Reptilia WNT4 36
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xwnt-4 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17939 35
wnt4 35
  • 73.79 (n)
  • 85.96 (a)
zebrafish
(Danio rerio)
Actinopterygii wnt4a 35
  • 75.88 (n)
  • 82.62 (a)
wnt4a 36
  • 82 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Wnt5 37
  • 45 (a)
Wnt6 37
  • 44 (a)
Wnt5 35
  • 52.97 (n)
  • 44.17 (a)
worm
(Caenorhabditis elegans)
Secernentea cwn-1 37
  • 46 (a)
cwn-2 37
  • 42 (a)
egl-20 37
  • 35 (a)
lin-44 37
  • 29 (a)
mom-2 37
  • 36 (a)
cwn-1 35
  • 50.54 (n)
  • 47.18 (a)
Species with no ortholog for WNT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT4 Gene

ENSEMBL:
Gene Tree for WNT4 (if available)
TreeFam:
Gene Tree for WNT4 (if available)

Paralogs for WNT4 Gene

genes like me logo Genes that share paralogs with WNT4: view

Variants for WNT4 Gene

Sequence variations from dbSNP and Humsavar for WNT4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_034703 Mullerian aplasia and hyperandrogenism (MULLAPL)
VAR_043497 Mullerian aplasia and hyperandrogenism (MULLAPL)
VAR_043498 Mullerian aplasia and hyperandrogenism (MULLAPL)
VAR_043499 46,XX sex reversal with dysgenesis of kidneys, adrenals, and lungs (SERKAL)
rs34228276 - 22,120,275(+) AAGTC(A/G)GGGCT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for WNT4 Gene

Variant ID Type Subtype PubMed ID
nsv871778 CNV Gain 21882294
nsv6076 CNV Insertion 18451855
nsv460806 CNV Loss 19166990

Variation tolerance for WNT4 Gene

Residual Variation Intolerance Score: 23.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WNT4 Gene

HapMap Linkage Disequilibrium report
WNT4
Human Gene Mutation Database (HGMD)
WNT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT4 Gene

Disorders for WNT4 Gene

MalaCards: The human disease database

(13) MalaCards diseases for WNT4 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
serkal syndrome
  • 46,xx sex reversal with dysgenesis of kidneys, adrenals and lungs
mullerian aplasia and hyperandrogenism
  • müllerian duct failure
wnt4-related 46,xy dsd and 46,xy cgd
hyperandrogenism
  • hyperandrogenization syndrome
mullerian aplasia
  • aplasia of the müllerian ducts
- elite association - COSMIC cancer census association via MalaCards
Search WNT4 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

WNT4_HUMAN
  • 46,XX sex reversal with dysgenesis of kidneys, adrenals, and lungs (SERKAL) [MIM:611812]: A disease characterized by the association of female-to-male sex reversal with dysgenesis of kidneys, adrenals, and lungs. {ECO:0000269 PubMed:18179883}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Mullerian aplasia and hyperandrogenism (MULLAPL) [MIM:158330]: A disorder of sex development. Affected females manifest dysgenesis of Mullerian duct derivatives absent or rudimentary uterus and vagina, functional ovaries, primary amenorrhea, hyperandrogenism and hirsutism. {ECO:0000269 PubMed:15317892, ECO:0000269 PubMed:16959810, ECO:0000269 PubMed:18182450}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for WNT4

Genetic Association Database (GAD)
WNT4
Human Genome Epidemiology (HuGE) Navigator
WNT4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WNT4
genes like me logo Genes that share disorders with WNT4: view

No data available for Genatlas for WNT4 Gene

Publications for WNT4 Gene

  1. Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. (PMID: 8168088) Huguet E.L. … Harris A.L. (Cancer Res. 1994) 2 3 4 23 67
  2. Variation in WNT genes expression in different subtypes of chronic lymphocytic leukemia. (PMID: 19863181) Memarian A. … Shokri F. (Leuk. Lymphoma 2009) 3 23
  3. WNT4 deficiency-a clinical phenotype distinct from the classic Mayer- Rokitansky-Kuster-Hauser syndrome: a case report. (PMID: 16959810) Biason-Lauber A. … Schoenle E.J. (Hum. Reprod. 2007) 3 23
  4. Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes. (PMID: 16442268) Yang L. … Hashimoto K. (J. Dermatol. Sci. 2006) 3 23
  5. Sustained Wnt protein expression in chondral constructs from mesenchymal stem cells. (PMID: 15389636) Nishioka K. … Caplan A.I. (J. Cell. Physiol. 2005) 3 23

Products for WNT4 Gene

Sources for WNT4 Gene

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