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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WNT3A Gene

protein-coding   GIFtS: 64
GCID: GC01P228194

wingless-type MMTV integration site family, member 3A
 Explore 30 diseases affiliated with
WNT3A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for WNT3A    

Aliases
for WNT3A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Wingless-Type MMTV Integration Site Family, Member 3A1 2
Protein Wnt-3a2

External Ids:    HGNC: 159831   Entrez Gene: 897802   Ensembl: ENSG000001543427   OMIM: 6063595   UniProtKB: P567043   

Export aliases for WNT3A gene to outside databases

Previous GC identifers: GC01P226691 GC01P223933 GC01P224580 GC01P225169 GC01P224501 GC01P226261 GC01P198726


Summaries
for WNT3A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for WNT3A:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins
have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and
patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96%
amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is
clustered with WNT14 gene, another family member, in chromosome 1q42 region. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: WNT3A_HUMAN, P56704
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct
roles in cell-cell signaling during morphogenesis of the developing neural tube

Gene Wiki entry for WNT3A


Genomic Views
for WNT3A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WNT3A gene promoter:
         AP-1   ATF-2   NF-kappaB   GATA-1   C/EBPalpha   HNF-4alpha1   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WNT3A promoter sequence
   Search SABiosciences Chromatin IP Primers for WNT3A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WNT3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42   Ensembl cytogenetic band:  1q42.13   HGNC cytogenetic band: 1q42

WNT3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT3A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P228194:  view genomic region     (about GC identifiers)

Start:
 228,194,752 bp from pter      End:
 228,248,961 bp from pter
Size:
 54,210 bases      Orientation:
 plus strand

Proteins
for WNT3A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: WNT3A_HUMAN, P56704 (See protein sequence)
Recommended Name: Protein Wnt-3a precursor  
Size: 352 amino acids; 39365 Da
Subunit: Homooligomer; disulfide-linked, leading to inactivation (By similarity). Interacts with PORCN. Interacts with
APCDD1 and WLS. Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD protein and
LRP5 or LRP6. Interacts directly in the complex with LRP6
Subcellular location: Secreted, extracellular space, extracellular matrix
Secondary accessions: Q3SY80 Q969P2

Explore the universe of human proteins at neXtProt for WNT3A: NX_P56704

Post-translational modifications:

  • Palmitoylation at Ser-209 is required for efficient binding to frizzled receptors. It is also required for subsequent
    • palmitoylation at Cys-77. Palmitoylation is required for proper trafficking to cell surface, vacuolar acidification is
    critical to release palmitoylated WNT3A from WLS in secretory vesicles1
  • Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading
    • to inactivation of WNT3A1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P56704

    • WNT3A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_149122.1  
    ENSEMBL proteins: 
     ENSP00000284523   ENSP00000355715  
    Reactome Protein details: P56704
    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for WNT3A (Wnt-3a)
    Enzo Life Sciences proteins for WNT3A
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: WNT3A
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    Novus Biologicals WNT3A Protein
    Novus Biologicals WNT3A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for WNT3A

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space ISS--
    GO:0005769early endosome IBA--
    GO:0005770late endosome IBA--


    WNT3A for ontologies           About GeneDecksing



    WNT3A Antibody Products: 
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    Uscn Antibodies for WNT3A
    Search ThermoFisher Antibodies for WNT3A

    Assay Products for WNT3A: 
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    Uscn ELISAs and CLIAs for WNT3A

    Protein Domains /
    Families
    for WNT3A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    WNT3A for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR005817 Wnt
     IPR009141 Wnt3
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry P56704

    ProtoNet protein and cluster: P56704

    1 Blocks protein family: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WNT3A_HUMAN, P56704
    Similarity: Belongs to the Wnt family


    Function
    for WNT3A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: WNT3A_HUMAN, P56704
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct
    roles in cell-cell signaling during morphogenesis of the developing neural tube

         Summary:  

    WNT3A as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Primitive Streak Mesendoderm cells, Definitive endoderm (see all 11).

    miRNA
    Products:            		miRTarBase miRNAs that target WNT3A:
    hsa-mir-15a (MIRT000282), hsa-mir-16 (MIRT003430)

    OriGene 3'-UTR Clone: WNT3A
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WNT3A
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate WNT3A (see all 19):
    hsa-miR-485-5p hsa-miR-15a hsa-miR-513a-5p hsa-miR-503 hsa-miR-128 hsa-miR-103a hsa-miR-424 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmid: WNT3A 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WNT3A (see all 7)
    OriGene shRNA RFP: WNT3A
    OriGene siRNA: WNT3A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WNT3A

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for WNT3A

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WNT3A (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WNT3A
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: WNT3A (NM_033131)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT3A 

    Cell Line
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    Search LifeMap BioReagents cell lines for WNT3A

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT3A

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity ISS--
    GO:0005109frizzled binding ----
    GO:0005110frizzled-2 binding IBA--
    GO:0005201extracellular matrix structural constituent NAS--
    GO:0005515protein binding IPI--


    WNT3A for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for WNT3A:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Wnt reporter upregulated 

    Animal Models:
         Mouse knock-outs for WNT3A: Wnt3atm1Amc Wnt3atm2Eag
         15/16 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Wnt3a) (see all 16):
     behavior/neurological  cardiovascular system  craniofacial  digestive/alimentary  embryogenesis 
     growth/size  hearing/vestibular/ear  limbs/digits/tail  mortality/aging  muscle 
     nervous system  no phenotypic analysis  renal/urinary system  reproductive system  respiratory system 

    WNT3A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for WNT3A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/19 super-pathways (see all 19) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Wnt Signaling Pathway
    		Wnt Signaling Pathway1.00
    		Wnt Signaling Pathway0.33
    		Wnt Signaling Pathway and Pluripotency0.55
    		Wnt signaling pathway0.30
    		DNA damage response (only ATM dependent)0.35
    		Wnt Signaling Pathway NetPath0.22
    2Basal cell carcinoma
    		Basal cell carcinoma1.00
    		Wnt Pathway0.37
    		Hedgehog signaling pathway0.41
    		Melanogenesis0.32
    3Translation_Non-genomic (rapid) action of Androgen Receptor
    		Translation_Non-genomic (rapid) action of Androgen Receptor1.00
    		Translation Non-genomic (rapid) action of Androgen Receptor0.99
    4Transcription_Androgen Receptor nuclear signaling
    		Transcription_Androgen Receptor nuclear signaling1.00
    		Transcription Androgen Receptor nuclear signaling0.99
    5Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency1.00
    		GSK3 Signaling0.61

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for WNT3A
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    1 R&D Systems Pathway for WNT3A
        Wnt Signaling Pathway

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for WNT3A (see all 8)
        GSK3 Signaling
    Factors Promoting Cardiogenesis in Vertebrates
    Presenilin-Mediated Signaling
    Human Embryonic Stem Cell Pluripotency
    Colorectal Cancer Metastasis

    1 Cell Signaling Technology (CST) Pathway for WNT3A
        Wnt / Hedgehog / Notch

    1 Tocris Bioscience Pathway for WNT3A
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT3A
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    5/8 BioSystems Pathways for WNT3A (see all 8) 
        Wnt Signaling Pathway
    Neural Crest Differentiation
    Wnt Signaling Pathway and Pluripotency
    DNA damage response (only ATM dependent)
    MicroRNAs in cardiomyocyte hypertrophy

    4        Reactome Pathways for WNT3A
        Signal Transduction
    Signaling by GPCR
    GPCR ligand binding
    Class B/2 (Secretin family receptors)


    5         Kegg Pathways  (Kegg details for WNT3A):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Melanogenesis
    Pathways in cancer
    Basal cell carcinoma


    WNT3A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WNT3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/47 Interacting proteins for WNT3A (P567041, 3 ENSP000002845234) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FZD1Q9UP383, ENSP000002879344I2D: score=3 STRING: ENSP00000287934
    RYKP349253, ENSP000002960844I2D: score=2 STRING: ENSP00000296084
    DLG1Q129593, ENSP000003457314I2D: score=1 STRING: ENSP00000345731
    DLG2Q157003, ENSP000003652724I2D: score=1 STRING: ENSP00000365272
    DLG4P783523, ENSP000002938134I2D: score=1 STRING: ENSP00000293813
    About this table

    Gene Ontology (GO): 5/71 biological process terms (GO ID links to tree view) (see all 71):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001649osteoblast differentiation IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0001756somitogenesis IBA--
    GO:0001934positive regulation of protein phosphorylation IDA--
    GO:0001947heart looping IEA--


    WNT3A for ontologies           About GeneDecksing



    Drugs & Compounds
    for WNT3A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    WNT3A for compounds           About GeneDecksing

    EMD Millipore small molecules for WNT3A:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WNT3A
    3 Novoseek chemical compound relationships for WNT3A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycogen 52.4 3 20442281 (1), 9391091 (1), 19887570 (1)
    retinoic acid 13.4 4 11788904 (3)
    testosterone 8.86 3 15604245 (2)

    Search CenterWatch for drugs/clinical trials and news about WNT3A 

    Transcripts
    for WNT3A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for WNT3A gene: 
    NM_033131.3  

    Unigene Cluster for WNT3A:

    Wingless-type MMTV integration site family, member 3A
    Hs.336930  [show with all ESTs]
    Unigene Representative Sequence: NM_033131
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000284523(uc001hrp.2 uc001hrq.2) ENST00000366753

    miRNA
    Products:             		 OriGene 3'-UTR Clone: WNT3A
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WNT3A
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate WNT3A (see all 19):
    hsa-miR-485-5p hsa-miR-15a hsa-miR-513a-5p hsa-miR-503 hsa-miR-128 hsa-miR-103a hsa-miR-424 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmid: WNT3A 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WNT3A (see all 7)
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WNT3A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WNT3A

    Additional cDNA sequence: 

    AB060284.1 AK056278.1 BC103921.1 BC103922.2 BC103923.1 

    2 DOTS entries:

    DT.102842409  DT.121447574 

    12 AceView cDNA sequences:

    NM_033131 AK056278 AB060284 CD634777 CD634771 CD634775 CD634773 CA437424 
    CD634766 H00219 BF995554 CD634769 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for WNT3A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
    SP1:                                          
    SP2:                                          


    ECgene alternative splicing isoforms for WNT3A

    Expression
    for WNT3A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WNT3A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCAGCGCCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    WNT3A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/11 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 11) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbLimb EctodermApical Ectodermal Ridge CellsDermis, Ectoderm
    EctodermEctodermIntraembryonic Ectoderm CellsEarly Embryo, Ectoderm
    EpiblastEpiblastIntraembryonic Epiblast CellsEarly Embryo
    LimbAutopodMesenchymal Condensate CellsBone, Cartilage
    LimbStylopodMesenchymal Condensate CellsBone, Cartilage
    LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    Primitive StreakPrimitive StreakPrimitive Streak CellsEarly Embryo
    TrophoblastExtraembryonic EctodermExtraembryonic Ectoderm CellsExtraembryonic Tissues, Placenta
    BrainThalamusBrain
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Endoderm-like cells (Functional hepatocyt...)

    See WNT3A Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.336930

    UniProtKB/Swiss-Prot: WNT3A_HUMAN, P56704
    Tissue specificity: Moderately expressed in placenta and at low levels in adult lung, spleen, and prostate

        SABiosciences Expression via Pathway-Focused PCR Arrays including WNT3A (see all 7): 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Targets in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WNT3A
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT3A

    Orthologs
    for WNT3A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for WNT3A gene from 3/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves WNT3A1 wingless-type MMTV integration site family, member more 78.69(n)
    87.78(a)    		   395396  NM_001171601.1  NP_001165072.1 
    lizard
    (Anolis carolinensis)    		 Reptilia WNT3A6
    		 --
    		 84(a)
    		 1 ↔ 1
    		 6(3407698-3441632)
    zebrafish
    (Danio rerio)    		 Actinopterygii wnt3a1 wingless-type MMTV integration site family, member more 78.5(n)
    85.47(a)    		   60632  NM_001007185.1  NP_001007186.1 


    ENSEMBL Gene Tree for WNT3A (if available)
    TreeFam Gene Tree for WNT3A (if available) 

    Paralogs
    for WNT3A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WNT3A gene
    WNT5B2  WNT162  WNT5A2  WNT62  WNT112  WNT22  WNT2B2  WNT12  
    WNT10B2  WNT42  WNT7A2  WNT7B2  WNT10A2  WNT32  
    18 SIMAP similar genes for WNT3A using alignment to 2 protein entries:     WNT3A_HUMAN (see all proteins):
    WNT3    WNT4    WNT7B    WNT7A    WNT2    WNT2B
    WNT1    WNT5B    WNT5A    WNT11    WNT16    WNT6
    WNT8A    WNT8B    WNT10B    WNT10A    WNT9B    WNT9A

    WNT3A for paralogs           About GeneDecksing



    Genomic Variants
    for WNT3A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/817 NCBI SNPs in WNT3A are shown (see all 817)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs761293081,2
    		C,F,--228192746(+) TGCCCC/GCNNNN 1 -- us2k11Minor allele frequency- G:0.03NA 120
    rs7081131,2
    		C,F,A,H,--228192753(-) ACCTCT/ACTGAA 1 -- us2k113Minor allele frequency- A:0.39NS EA NA CSA WA 788
    rs1380159411,2
    		--228192881(+) GGCGCA/CCACCC 1 -- us2k10--------
    rs762701581,2
    		--228192967(+) AAACAC/AGCTCC 1 -- us2k13Minor allele frequency- A:0.20CSA WA 121
    rs1384034781,2
    		C,--228192988(+) CTCCC-/TGACCCCA 1 -- us2k10--------
    rs1817725261,2
    		--228193092(+) GTAGCA/GGAAAC 1 -- us2k10--------
    rs1861282311,2
    		--228193368(+) CCATCA/CCTGCC 1 -- us2k10--------
    rs746726291,2
    		C,F,--228193393(+) CCTCCC/GGCAAC 1 -- us2k12Minor allele frequency- G:0.09NA EA 240
    rs1128715891,2
    		--228193412(+) CGCACA/GGGAGG 1 -- us2k13Minor allele frequency- G:0.21CSA WA 121
    rs769205651,2
    		F,--228193414(+) CACAGG/AAGGCC 1 -- us2k11Minor allele frequency- A:0.03NA 120

    HapMap Linkage Disequilibrium report for WNT3A (228194752 - 228248961 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for WNT3A
         1 CNV: 6812
    Human Gene Mutation Database (HGMD): WNT3A

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    Disorders / Diseases
    for WNT3A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    WNT3A for disorders           About GeneDecksing

    OMIM gene information: 606359    OMIM disorders: --

    20/30 diseases for WNT3A (see all 30):    About MalaCards
    focal dermal hypoplasia    hypotrichosis simplex    hypotrichosis    idiopathic pulmonary fibrosis
    cleft lip    cleft palate    pulmonary fibrosis    acute lymphoblastic leukemia
    basal cell carcinoma    lymphoblastic leukemia    insulin resistance    multiple myeloma
    scoliosis    microphthalmia    fibrosis    prostate cancer
    breast cancer    hermaphroditism    myeloma    hepatocellular carcinoma

    1 disease from the University of Copenhagen DISEASES database for WNT3A:
    Cancer

    6 Novoseek disease relationships for WNT3A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 32 3 15604245 (1), 18724388 (1)
    gastric cancer 19.4 2 11414706 (1), 11788904 (1)
    cancer 19.2 4 11788904 (2), 11414706 (1), 16425220 (1)
    necrosis 0 2 11788904 (1), 19351711 (1)
    breast cancer 0 1 11788904 (1)
    tumors 0 3 11788904 (1), 18212053 (1), 19351711 (1)

    Human Genome Epidemiology (HuGE) Navigator: WNT3A (10 documents)

    Export disorders for WNT3A gene to outside databases

    Publications
    for WNT3A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WNT3A gene, integrated from 9 sources (see all 157):
    (articles sorted by number of sources associating them with WNT3A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of WNT3a and WNT14 clustered in human chromosome 1q42 region. (PubMed id 11414706)1, 2, 3, 9 Saitoh T.... Katoh M. (2001)
    2. Reconstitution of a frizzled8.Wnt3a.LRP6 signaling co mplex reveals multiple Wnt and Dkk1 binding sites on LRP6. (PubMed id 20093360)1, 2 Bourhis E....Hannoush R.N. (2010)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. (PubMed id 8168088)1, 2 Huguet E.L.... Harris A.L. (1994)
    7. Regulation of WNT3 and WNT3A mRNAs in human cancer cell lines NT2, MCF-7, and MKN45. (PubMed id 11788904)1, 9 Katoh M. (2002)
    8. Effects of Wnt3a on proliferation and differentiation of human epidermal stem cells. (PubMed id 18242164)1, 9 Jia L....Duan E. (2008)
    9. Prostate tumor progression is mediated by a paracrine TGF-beta/Wnt3a signaling axis. (PubMed id 18724388)1, 9 Li X....Bhowmick N.A. (2008)
    10. Prostate cancer induces bone metastasis through Wnt-induced bone morphogenetic protein-dependent and independent mechanisms. (PubMed id 18632632)1, 9 Dai J....Keller E.T. (2008)

    External Searches for WNT3A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing WNT3A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 89780 HGNC: 15983 AceView: WNT3A Ensembl:ENSG00000154342 euGenes: HUgn89780
    ECgene: WNT3A Kegg: 89780 H-InvDB: WNT3A

    Other Databases showing WNT3A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing WNT3A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WNT3A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT3A Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for WNT3A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for WNT3A gene:
    Search GeneIP for patents involving WNT3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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