External Ids for WNT3A Gene
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. [provided by RefSeq, Jul 2008]
GeneCards Summary for WNT3A Gene
WNT3A (Wingless-Type MMTV Integration Site Family, Member 3A) is a Protein Coding gene. Diseases associated with WNT3A include idiopathic juvenile osteoporosis and hypotrichosis simplex. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include transcription coactivator activity and extracellular matrix structural constituent. An important paralog of this gene is WNT1.
UniProtKB/Swiss-Prot for WNT3A Gene
Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube