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WNT3A Gene

protein-coding   GIFtS: 64
GCID: GC01P228194

Wingless-Type MMTV Integration Site Family, Member 3A

  See WNT3A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Wingless-Type MMTV Integration Site Family, Member 3A1 2
Protein Wnt-3a2

External Ids:    HGNC: 159831   Entrez Gene: 897802   Ensembl: ENSG000001543427   OMIM: 6063595   UniProtKB: P567043   

Export aliases for WNT3A gene to outside databases

Previous GC identifers: GC01P226691 GC01P223933 GC01P224580 GC01P225169 GC01P224501 GC01P226261 GC01P198726


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WNT3A Gene:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These
proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell
fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein
which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene
product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. (provided by
RefSeq, Jul 2008)

GeneCards Summary for WNT3A Gene:
WNT3A (wingless-type MMTV integration site family, member 3A) is a protein-coding gene. Diseases associated with WNT3A include osteoporosis, early-onset autosomal dominant, and hypotrichosis simplex. GO annotations related to this gene include extracellular matrix structural constituent and transcription coactivator activity. An important paralog of this gene is WNT5B.

UniProtKB/Swiss-Prot: WNT3A_HUMAN, P56704
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play
distinct roles in cell-cell signaling during morphogenesis of the developing neural tube

Gene Wiki entry for WNT3A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_167186.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WNT3A gene promoter:
         AP-1   ATF-2   NF-kappaB   GATA-1   C/EBPalpha   HNF-4alpha1   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWNT3A promoter sequence
   Search Chromatin IP Primers for WNT3A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WNT3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42   Ensembl cytogenetic band:  1q42.13   HGNC cytogenetic band: 1q42

WNT3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT3A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P228194:  view genomic region     (about GC identifiers)

Start:
228,194,723 bp from pter      End:
228,248,972 bp from pter
Size:
54,250 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: WNT3A_HUMAN, P56704 (See protein sequence)
Recommended Name: Protein Wnt-3a precursor  
Size: 352 amino acids; 39365 Da
Subunit: Homooligomer; disulfide-linked, leading to inactivation (By similarity). Interacts with PORCN. Interacts
with APCDD1 and WLS. Component of the Wnt-Fzd-LRP5-LRP6 signaling complex that contains a WNT protein, a FZD
protein and LRP5 or LRP6. Interacts directly in the complex with LRP6
Secondary accessions: Q3SY79 Q3SY80 Q969P2
Alternative splicing: 2 isoforms:  P56704-1   P56704-2   

Explore the universe of human proteins at neXtProt for WNT3A: NX_P56704

Explore proteomics data for WNT3A at MOPED

Post-translational modifications: 

  • Palmitoylation at Ser-209 is required for efficient binding to frizzled receptors. It is also required for
    subsequent palmitoylation at Cys-77. Palmitoylation is required for proper trafficking to cell surface, vacuolar
    acidification is critical to release palmitoylated WNT3A from WLS in secretory vesicles1
  • Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers,
    leading to inactivation of WNT3A1
  • Glycosylation2 at Asn87, Asn298

  • See WNT3A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_149122.1  
    ENSEMBL proteins: 
     ENSP00000284523   ENSP00000355715  
    Reactome Protein details: P56704

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    Search eBioscience for ELISAs for WNT3A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    WNT: Wingless-type MMTV integration sites

    3 InterPro protein domains:
     IPR009141 Wnt3
     IPR005817 Wnt
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry P56704

    ProtoNet protein and cluster: P56704

    1 Blocks protein domain: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WNT3A_HUMAN, P56704
    Similarity: Belongs to the Wnt family


    Find genes that share domains with WNT3A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WNT3A_HUMAN, P56704
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play
    distinct roles in cell-cell signaling during morphogenesis of the developing neural tube

         Summary: 

    During embryonic development, WNT3A as signaling molecule is secreted from the following cells:
                
    Neural Tube: Spinal Neural Tube Cells (Neural Tube)

    It affects the following cells:       fully expand
    Neural Tube: Lateral Ganglionic Eminence Progenitor Cells (Anterior Entopeduncular Area), Medial Ganglionic Eminence Progenitor Cells (Caudal Ganglionic Eminence)      fully expand to see all 4 cells

    WNT3A as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
          selected tissues (see all 6)      fully expand
    Primitive Streak: Primitive Streak Mesendoderm cells, Mesendoderm-like cells      fully expand to see all 3 cells
    Endoderm: Definitive endoderm-like cells, Definitive endoderm      fully expand to see all 2 cells

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity ISS--
    GO:0005102receptor binding ----
    GO:0005109frizzled binding IBA--
    GO:0005110frizzled-2 binding IEA--
    GO:0005201extracellular matrix structural constituent ----
         
    Find genes that share ontologies with WNT3A           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for WNT3A:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Wnt reporter upregulated 

         Selected MGI mutant phenotypes (inferred from 6 alleles(MGI details for Wnt3a) (see all 16):
     behavior/neurological  cardiovascular system  craniofacial  digestive/alimentary  embryogenesis 
     growth/size/body  hearing/vestibular/ear  limbs/digits/tail  mortality/aging  muscle 
     nervous system  no phenotypic analysis  renal/urinary system  reproductive system  respiratory system 

    Find genes that share phenotypes with WNT3A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for WNT3A: Wnt3atm1Amc Wnt3atm2Eag

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WNT3A
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WNT3A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WNT3A

    miRNA
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    miRTarBase miRNAs that target WNT3A:
    hsa-mir-181a-5p (MIRT025061), hsa-mir-132-3p (MIRT021725), hsa-mir-15a-5p (MIRT000282), hsa-mir-103a-3p (MIRT027132), hsa-mir-128-3p (MIRT021973), hsa-mir-16-5p (MIRT003430)

    Block miRNA regulation of human, mouse, rat WNT3A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WNT3A (see all 19):
    hsa-miR-485-5p hsa-miR-15a hsa-miR-513a-5p hsa-miR-503 hsa-miR-128 hsa-miR-103a hsa-miR-424 hsa-miR-195
    SwitchGear 3'UTR luciferase reporter plasmidWNT3A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat WNT3A

    Gene Editing
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    In Situ Assay
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WNT3A_HUMAN, P56704: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endosome3
    plasma membrane3
    nucleus2
    cytoskeleton1
    golgi apparatus1
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space ISS--
    GO:0005737cytoplasm ----
    GO:0005788endoplasmic reticulum lumen TAS--

    Find genes that share ontologies with WNT3A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WNT3A About   (see all 27)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathways0.40
    2Wnt Pathway
    Wnt Pathway0.56
    WNT ligand biogenesis and trafficking0.56
    3Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway0.55
    DNA damage response (only ATM dependent)0.32
    Wnt Signaling Pathway and Pluripotency0.55
    4Basal cell carcinoma
    Basal cell carcinoma0.43
    Melanogenesis0.32
    Hedgehog signaling pathway0.43
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58


    Find genes that share SuperPaths with WNT3A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for WNT3A
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for WNT3A (see all 8)
        GSK3 Signaling
    Factors Promoting Cardiogenesis in Vertebrates
    Presenilin-Mediated Signaling
    Human Embryonic Stem Cell Pluripotency
    Colorectal Cancer Metastasis

    1 Cell Signaling Technology (CST) Pathway for WNT3A
        Wnt / Hedgehog / Notch

    1 Tocris Bioscience Pathway for WNT3A
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT3A
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    Selected BioSystems Pathways for WNT3A (see all 10)
        MicroRNAs in cardiomyocyte hypertrophy
    Wnt Signaling Pathway
    DNA damage response (only ATM dependent)
    Wnt Signaling Pathway and Pluripotency
    Cardiac Progenitor Differentiation


    Selected Reactome Pathways for WNT3A (see all 6)
        regulation of FZD by ubiquitination
    disassembly of the destruction complex and recruitment of AXIN to the membrane
    WNT ligand biogenesis and trafficking
    negative regulation of TCF-dependent signaling by WNT ligand antagonists
    TCF dependent signaling in response to WNT


    Selected Kegg Pathways  (Kegg details for WNT3A) (see all 9):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT3A (see all 7): 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Targets in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for WNT3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WNT3A (P567041, 3 ENSP000002845234) via UniProtKB, MINT, STRING, and/or I2D (see all 121)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FZD1Q9UP383, ENSP000002879344I2D: score=3 STRING: ENSP00000287934
    RYKP349253, ENSP000002960844I2D: score=2 STRING: ENSP00000296084
    CDH2P190223, ENSP000002691414I2D: score=1 STRING: ENSP00000269141
    DLG1Q129593, ENSP000003457314I2D: score=1 STRING: ENSP00000345731
    DLG2Q157003, ENSP000003652724I2D: score=1 STRING: ENSP00000365272
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 64):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001649osteoblast differentiation IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0001756somitogenesis ----
    GO:0001934positive regulation of protein phosphorylation IDA--
    GO:0001947heart looping IEA--

    Find genes that share ontologies with WNT3A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WNT3A

    3 Novoseek inferred chemical compound relationships for WNT3A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycogen 52.4 3 20442281 (1), 9391091 (1), 19887570 (1)
    retinoic acid 13.4 4 11788904 (3)
    testosterone 8.86 3 15604245 (2)



    Find genes that share compounds with WNT3A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WNT3A gene: 
    NM_033131.3  

    Unigene Cluster for WNT3A:

    Wingless-type MMTV integration site family, member 3A
    Hs.336930  [show with all ESTs]
    Unigene Representative Sequence: NM_033131
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000284523(uc001hrp.2 uc001hrq.2) ENST00000366753
    miRNA
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    hsa-miR-485-5p hsa-miR-15a hsa-miR-513a-5p hsa-miR-503 hsa-miR-128 hsa-miR-103a hsa-miR-424 hsa-miR-195
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      QuantiTect SYBR Green Assays in human, mouse, rat WNT3A
      QuantiFast Probe-based Assays in human, mouse, rat WNT3A

    Additional mRNA sequence: 

    AB060284.1 AK056278.1 BC103921.1 BC103922.2 BC103923.1 

    2 DOTS entries:

    DT.102842409  DT.121447574 

    12 AceView cDNA sequences:

    AB060284 NM_033131 AK056278 CD634777 CD634775 CD634771 CD634766 CD634773 
    CA437424 H00219 CD634769 BF995554 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for WNT3A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
    SP1:                                          
    SP2:                                          


    ECgene alternative splicing isoforms for WNT3A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WNT3A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAGCGCCC
    WNT3A Expression
    About this image


    WNT3A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Apical Ectodermal Ridge Cells Limb Ectoderm
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Spinal Neural Tube Cells Neural Tube
             Metencephalon
     
     Ectoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Apical Ectodermal Ridge Cells Limb Ectoderm
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
    WNT3A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WNT3A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.336930

    UniProtKB/Swiss-Prot: WNT3A_HUMAN, P56704
    Tissue specificity: Moderately expressed in placenta and at low levels in adult lung, spleen, and prostate

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT3A (see all 7): 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Targets in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WNT3A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wnt3a1 , 5 wingless-related MMTV integration site 3A1, 5 87.5(n)1
    96.02(a)1
      11 (37.17 cM)5
    224161  NM_009522.21  NP_033548.11 
     592480335 
    chicken
    (Gallus gallus)
    Aves WNT3A1 wingless-type MMTV integration site family, member more 78.69(n)
    87.78(a)
      395396  NM_001171601.1  NP_001165072.1 
    lizard
    (Anolis carolinensis)
    Reptilia WNT3A6
    Protein Wnt
    89(a)
    1 ↔ 1
    6(3404801-3441426)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia wnt3a1 wingless-type MMTV integration site family, member more 73.96(n)
    84.66(a)
      100488632  XM_002939308.2  XP_002939354.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wnt3a1 wingless-type MMTV integration site family, member more 78.5(n)
    85.47(a)
      60632  NM_001007185.1  NP_001007186.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cwn-13 Expression: embryo, L1 larva, L2 larva,
    L3 larva, more
    41(a)
    (best of 5)
      II(131165-133577)   --


    ENSEMBL Gene Tree for WNT3A (if available)
    TreeFam Gene Tree for WNT3A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WNT3A gene
    WNT5B2  WNT162  WNT62  WNT5A2  WNT112  WNT22  WNT2B2  WNT12  
    WNT42  WNT7A2  WNT7B2  WNT32  
    17 SIMAP similar genes for WNT3A using alignment to 1 protein entry:     WNT3A_HUMAN:
    WNT3    WNT4    WNT7B    WNT7A    WNT2    WNT2B
    WNT1    WNT5B    WNT5A    WNT11    WNT16    WNT6
    WNT8A    WNT8B    WNT10B    WNT10A    WNT9B

    Find genes that share paralogs with WNT3A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WNT3A (see all 1031)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs761293081,2
    C,F--228192746(+) TGCCCC/GCTTCA 1 -- us2k11Minor allele frequency- G:0.03NA 120
    rs7081131,2
    C,F,A,H--228192753(-) ACCTCT/ACTGAA 1 -- us2k113Minor allele frequency- A:0.39NS EA NA CSA WA 788
    rs1380159411,2
    --228192881(+) GGCGCA/CCACCC 1 -- us2k10--------
    rs762701581,2
    C,F--228192967(+) AAACAC/AGCTCC 1 -- us2k13Minor allele frequency- A:0.20CSA WA 121
    rs1384034781,2
    C--228192988(+) CTCCC-/TGACCCCA 1 -- us2k10--------
    rs1817725261,2
    --228193092(+) GTAGCA/GGAAAC 1 -- us2k10--------
    rs1861282311,2
    --228193368(+) CCATCA/CCTGCC 1 -- us2k10--------
    rs746726291,2
    C,F--228193393(+) CCTCCC/GGCAAC 1 -- us2k12Minor allele frequency- G:0.09NA EA 240
    rs1128715891,2
    C,F--228193412(+) CGCACA/GGGAGG 1 -- us2k13Minor allele frequency- G:0.21CSA WA 121
    rs769205651,2
    F--228193414(+) CACAGG/AAGGCC 1 -- us2k11Minor allele frequency- A:0.03NA 120

    HapMap Linkage Disequilibrium report for WNT3A (228194723 - 228248972 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for WNT3A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv523935CNV Loss19592680
    nsv516409CNV Loss19592680
    nsv832803CNV Loss17160897
    dgv537n71CNV Loss21882294
    nsv873252CNV Loss21882294
    nsv826953CNV Gain20364138
    nsv826964CNV Gain20364138
    esv32853CNV Gain17666407
    nsv826908CNV Gain20364138

    Human Gene Mutation Database (HGMD): WNT3A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WNT3A
    DNA2.0 Custom Variant and Variant Library Synthesis for WNT3A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606359    OMIM disorders: --

    2 diseases for WNT3A:    
    About MalaCards
    osteoporosis, early-onset autosomal dominant    hypotrichosis simplex

    1 disease from the University of Copenhagen DISEASES database for WNT3A:
    Cancer

    Find genes that share disorders with WNT3A           About GenesLikeMe

    6 Novoseek inferred disease relationships for WNT3A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 32 3 15604245 (1), 18724388 (1)
    gastric cancer 19.4 2 11414706 (1), 11788904 (1)
    cancer 19.2 4 11788904 (2), 11414706 (1), 16425220 (1)
    necrosis 0 2 11788904 (1), 19351711 (1)
    breast cancer 0 1 11788904 (1)
    tumors 0 3 11788904 (1), 18212053 (1), 19351711 (1)

    Genetic Association Database (GAD): WNT3A
    Human Genome Epidemiology (HuGE) Navigator: WNT3A (10 documents)

    Export disorders for WNT3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WNT3A gene, integrated from 10 sources (see all 175):
    (articles sorted by number of sources associating them with WNT3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of WNT3a and WNT14 clustered in human chromosome 1q42 region. (PubMed id 11414706)1, 2, 3, 9 Saitoh T.... Katoh M. (Biochem. Biophys. Res. Commun. 2001)
    2. Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6. (PubMed id 20093360)1, 2 Bourhis E.... Hannoush R.N. (J. Biol. Chem. 2010)
    3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    4. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    5. Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate. (PubMed id 18413325)1, 4 Chiquet B.T....Hecht J.T. (Hum. Mol. Genet. 2008)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. (PubMed id 8168088)1, 2 Huguet E.L.... Harris A.L. (Cancer Res. 1994)
    10. Regulation of WNT3 and WNT3A mRNAs in human cancer cell lines NT2, MCF-7, and MKN45. (PubMed id 11788904)1, 9 Katoh M. (Int. J. Oncol. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 89780 HGNC: 15983 AceView: WNT3A Ensembl:ENSG00000154342 euGenes: HUgn89780
    ECgene: WNT3A Kegg: 89780 H-InvDB: WNT3A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WNT3A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT3A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WNT3A gene:
    Search GeneIP for patents involving WNT3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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