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WNT3 Gene

protein-coding   GIFtS: 65
GCID: GC17M044839

Wingless-Type MMTV Integration Site Family, Member 3


(Previous symbol: INT4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Wingless-Type MMTV Integration Site Family, Member 31 2
INT41 2 3 5
WNT-3 Proto-Oncogene Protein1 2
Proto-Oncogene Int-4 Homolog2 3
Proto-Oncogene Wnt-32

External Ids:    HGNC: 127821   Entrez Gene: 74732   Ensembl: ENSG000001083797   OMIM: 1653305   UniProtKB: P567033   

Export aliases for WNT3 gene to outside databases

Previous GC identifers: GC17M044339 GC17M047240 GC17M045183 GC17M045316 GC17M042196 GC17M040220


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WNT3 Gene:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These
proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell
fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein
which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene
product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the
gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and
gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with
WNT15, another family member, in the chromosome 17q21 region. (provided by RefSeq, Jul 2008)

GeneCards Summary for WNT3 Gene:
WNT3 (wingless-type MMTV integration site family, member 3) is a protein-coding gene. Diseases associated with WNT3 include tetra-amelia syndrome, and oral leukoplakia. GO annotations related to this gene include receptor agonist activity and protein domain specific binding. An important paralog of this gene is WNT5B.

UniProtKB/Swiss-Prot: WNT3_HUMAN, P56703
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play
distinct roles in cell-cell signaling during morphogenesis of the developing neural tube (By similarity)

Gene Wiki entry for WNT3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  NT_167251.2  NT_187663.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the WNT3 gene promoter:
         p53   Nkx2-5   HNF-4alpha2   GATA-2   E47   HNF-4alpha1   Pax-3   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWNT3 promoter sequence
   Search Chromatin IP Primers for WNT3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WNT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21-q22

WNT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M044839:  view genomic region     (about GC identifiers)

Start:
44,839,872 bp from pter      End:
44,910,520 bp from pter
Size:
70,649 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: WNT3_HUMAN, P56703 (See protein sequence)
Recommended Name: Proto-oncogene Wnt-3 precursor  
Size: 355 amino acids; 39645 Da
Subunit: Interacts with PORCN (By similarity). Interacts with WLS (By similarity)
Secondary accessions: Q2M237 Q9H1J9

Explore the universe of human proteins at neXtProt for WNT3: NX_P56703

Explore proteomics data for WNT3 at MOPED

Post-translational modifications: 

  • Palmitoylation at Ser-212 is required for efficient binding to frizzled receptors. It is also required for
    subsequent palmitoylation at Cys-80. Palmitoylation is necessary for proper trafficking to cell surface (By
    similarity)1
  • Glycosylation2 at Asn90, Asn301

  • See WNT3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_110380.1  
    ENSEMBL proteins: 
     ENSP00000225512  
    Reactome Protein details: P56703

    WNT3 Human Recombinant Protein Products:

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    Novus Biologicals WNT3 Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WNT3

    WNT3 Antibody Products:

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    WNT3 Assay Products:

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    Cloud-Clone Corp. ELISAs for WNT3
    Cloud-Clone Corp. CLIAs for WNT3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    WNT: Wingless-type MMTV integration sites

    3 InterPro protein domains:
     IPR009141 Wnt3
     IPR005817 Wnt
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry P56703

    ProtoNet protein and cluster: P56703

    1 Blocks protein domain: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WNT3_HUMAN, P56703
    Similarity: Belongs to the Wnt family


    WNT3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WNT3_HUMAN, P56703
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play
    distinct roles in cell-cell signaling during morphogenesis of the developing neural tube (By similarity)

         Genatlas biochemistry entry for WNT3:
    wingless-type MMTV integration site 3,Drosophila wingless (wg) segment polarity gene homolog,expressed in
    developing nervous system and in adult thalamus,cerebellum,pons,modulating cell fate and cell behavior during
    vertebrate development,required for the primary axis formation

         Summary: 
    During embryonic development, WNT3 as signaling molecule is secreted from the following cells:
                
    Epiblast: Intraembryonic Epiblast Cells (Epiblast)
    Trophoblast: Extraembryonic Ectoderm Cells (Extraembryonic Ectoderm)

    It affects the following cells:
    Epiblast: Intraembryonic Epiblast Cells (Epiblast)
    Neural Crest: Melanocytes (Trunk Neural Crest)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005109frizzled binding IPI10557084
    GO:0005515protein binding IPI18313787
    GO:0019904protein domain specific binding IEA--
    GO:0048018receptor agonist activity IC18044981
         
    WNT3 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Wnt3):
     cellular  embryogenesis  growth/size/body  limbs/digits/tail  mortality/aging 
     no phenotypic analysis  normal  reproductive system 

    WNT3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for WNT3: Wnt3tm1Brd Wnt3tm1Amc

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WNT3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for WNT3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WNT3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WNT3

    miRNA
    Products:
        
    miRTarBase miRNAs that target WNT3:
    hsa-mir-215-5p (MIRT024672), hsa-mir-1301-3p (MIRT036062), hsa-mir-192-5p (MIRT026683), hsa-mir-335-5p (MIRT018503)

    Block miRNA regulation of human, mouse, rat WNT3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WNT3 (see all 10):
    hsa-miR-362-3p hsa-miR-520a-5p hsa-miR-329 hsa-miR-19b hsa-miR-525-5p hsa-miR-518a-5p hsa-miR-3143 hsa-miR-3925-5p
    SwitchGear 3'UTR luciferase reporter plasmidWNT3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat WNT3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: WNT3 (NM_030753)
    Sino Biological Human cDNA Clone for WNT3
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WNT3_HUMAN, P56703: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endosome3
    plasma membrane3
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space TAS18313787
    GO:0005737cytoplasm ----
    GO:0005788endoplasmic reticulum lumen TAS--

    WNT3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WNT3 About   (see all 24)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt Pathway
    Wnt Pathway0.56
    WNT ligand biogenesis and trafficking0.56
    2Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    3Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway0.55
    DNA damage response (only ATM dependent)0.32
    Wnt Signaling Pathway and Pluripotency0.55
    4Basal cell carcinoma
    Basal cell carcinoma0.43
    Melanogenesis0.32
    Hedgehog signaling pathway0.43
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for WNT3 (see all 9)
        G12-G13 in Cellular Signaling
    Colorectal Cancer Metastasis
    GSK3 Signaling
    Reelin Pathway (Cajal-Retzius cells)
    Presenilin-Mediated Signaling

    1 Tocris Bioscience Pathway for WNT3
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT3
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    5 BioSystems Pathways for WNT3
        Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    DNA damage response (only ATM dependent)
    Wnt Signaling Pathway NetPath
    Wnt signaling network

    2 Sino Biological Pathways for WNT3
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    3 Reactome Pathways for WNT3
        WNT ligand biogenesis and trafficking
    TCF dependent signaling in response to WNT
    Class B/2 (Secretin family receptors)


    Selected Kegg Pathways  (Kegg details for WNT3) (see all 9):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection


    WNT3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT3: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for WNT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WNT3 (P567033 ENSP000002255124) via UniProtKB, MINT, STRING, and/or I2D (see all 86)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FZD1Q9UP383, ENSP000002879344I2D: score=1 STRING: ENSP00000287934
    FZD7O750843, ENSP000002862014I2D: score=1 STRING: ENSP00000286201
    KLQ9UEF73, ENSP000003694424I2D: score=1 STRING: ENSP00000369442
    PORCNQ9H2373, ENSP000003223044I2D: score=3 STRING: ENSP00000322304
    FZD5ENSP000003546074STRING: ENSP00000354607
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis IMP15588944
    GO:0001707mesoderm formation IEA--
    GO:0007275multicellular organismal development ----
    GO:0007411axon guidance IEA--
    GO:0009948anterior/posterior axis specification IEA--

    WNT3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    7 ApexBio Compounds for WNT3     About this table
    CompoundAction CAS #
    CHIR-99021 (CT99021)Cell-permeable, ATP-competitive GSK-3 inhibitor[252917-06-9]
    FH535suppresses both Wnt/beta-catenin and peroxisome proliferator-activated receptor (PPAR) signaling. [108409-83-2]
    ICG 001Wnt/beta-catenin path[847591-62-2]
    JW 55Cell-permeable, reversible tankyrase 1 and 2 inhibitor, inhibits beta-catenin mediated canonical Wnt pathway[664993-53-7]
    KY 02111Canonical Wnt pathway inhibitor, promotes stem cell differentiation to cadiomyocytes[1118807-13-8]
    Salinomycin sodium saltantibacterial and coccidiostat ionophore therapeutic drug[55721-31-8]
    XAV-939Tankyrase inhibitor, also inhibits beta-catenin mediated Wnt pathway[284028-89-3]

    Browse Tocris compounds for WNT3

    1 Novoseek inferred chemical compound relationship for WNT3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 26.9 4 11788904 (2), 11786923 (1)



    WNT3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for WNT3 gene: 
    NM_030753.4  

    Unigene Cluster for WNT3:

    Wingless-type MMTV integration site family, member 3
    Hs.445884  [show with all ESTs]
    Unigene Representative Sequence: BC114219
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000225512(uc002ikv.2) ENST00000573788 ENST00000572508 ENST00000576471

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate WNT3 (see all 10):
    hsa-miR-362-3p hsa-miR-520a-5p hsa-miR-329 hsa-miR-19b hsa-miR-525-5p hsa-miR-518a-5p hsa-miR-3143 hsa-miR-3925-5p
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      QuantiFast Probe-based Assays in human, mouse, rat WNT3

    Additional mRNA sequence: 

    AB067628.1 AY009397.1 BC112116.1 BC112118.1 BC114219.1 

    2 DOTS entries:

    DT.102839944  DT.405345 

    15 AceView cDNA sequences:

    NM_030753 AY009397 BX281024 AB067628 CD632710 CD632708 BF515681 CD632706 
    AI638412 CD632707 CD632703 CD632709 AA634318 CD632705 CD632704 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WNT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTTTTTTT
    WNT3 Expression
    About this image


    WNT3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Epithelial Cells
             Fetal Precortex Cells Hair Shaft
     
     Hair
             Fetal Precortex Cells Hair Shaft
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 6 entries
             Primitive Streak Cells Posterior Primitive Streak
             Primitive streak-like cells
     
     Epiblast (Early Embryo)    fully expand to see all 4 entries
             Primitive Streak Cells Posterior Primitive Streak
             Epiblast Stem Cell line 7
             Epiblast-like cells
     
     Hypoblast (Extraembryonic Tissues)    fully expand to see all 3 entries
             Hypoblast Cells Hypoblast
    WNT3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WNT3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445884
        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT3: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat WNT3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WNT3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wnt31 , 5 wingless-related MMTV integration site 31, 5 92.49(n)1
    98.87(a)1
      11 (67.50 cM)5
    224151  NM_009521.21  NP_033547.11 
     1037741505 
    chicken
    (Gallus gallus)
    Aves WNT31 wingless-type MMTV integration site family, member 3 less 83.76(n)
    96.06(a)
      374142  NM_001081696.1  NP_001075165.1 
    lizard
    (Anolis carolinensis)
    Reptilia WNT36
    wingless-type MMTV integration site family, member...
    96(a)
    1 ↔ 1
    6(65550323-65582871)
    African clawed frog
    (Xenopus laevis)
    Amphibia wnt3a-A2 wingless-type MMTV integration site family, member 3 less 75.94(n)    L07538.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wnt31 wingless-type MMTV integration site family, member 3 less 78.66(n)
    92.63(a)
      569420  NM_001114552.2  NP_001108024.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cwn-13 Expression: embryo, L1 larva, L2 larva,
    L3 larva, L4 larva, adult less
    42(a)
    (best of 3)
      II(131165-133577)   --


    ENSEMBL Gene Tree for WNT3 (if available)
    TreeFam Gene Tree for WNT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WNT3 gene
    WNT5B2  WNT162  WNT62  WNT5A2  WNT112  WNT22  WNT2B2  WNT3A2  
    WNT12  WNT42  WNT7A2  WNT7B2  
    18 SIMAP similar genes for WNT3 using alignment to 1 protein entry:     WNT3_HUMAN:
    WNT3A    WNT4    WNT7B    WNT2    WNT1    WNT7A
    WNT2B    WNT5B    WNT11    WNT5A    WNT16    WNT6
    WNT8A    WNT8B    WNT10A    WNT9A    WNT9B    WNT10B

    WNT3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WNT3 (see all 1108)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1048946531,2
    Cpathogenic145865408(-) AGCACC/TAGTTC 2 Q * stg10--------
    rs358620771,2
    C--40254817(+) TCTCAA/-AAAAA 1 -- int11Minor allele frequency- -:0.00NA 2
    rs58206221,2
    C--40256289(+) CTCTT-/AACACT 1 -- int11Minor allele frequency- A:0.00CSA 2
    rs80780291,2
    C,A--44839623(+) AGTACA/CCAAGT 1 -- ds50012Minor allele frequency- C:0.00NA 4
    rs1475008701,2
    C--44839655(+) ATTCAC/TTGTTA 1 -- ds50010--------
    rs760765731,2
    C,F--44839671(+) TAACTT/GAGAAC 1 -- ds50011Minor allele frequency- G:0.03NA 120
    rs346337431,2
    C,F,H--44841205(+) AAAAAA/CAAAAA 2 -- ut3114Minor allele frequency- C:0.21NS EA NA 1978
    rs353598011,2
    C,F,H--44841209(+) AAAAAA/CAAACA 2 -- ut318Minor allele frequency- C:0.13NS NA 1142
    rs2004675231,2
    C--44841209(+) AAAAAA/CAAACA 1 -- ut310--------
    rs733045151,2
    C,F--44856421(+) CCATCT/ACACAC 1 -- int12Minor allele frequency- A:0.33WA CSA 3

    HapMap Linkage Disequilibrium report for WNT3 (44839872 - 44910520 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for WNT3 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659354CNV Deletion23128226
    esv1005788CNV Deletion20482838
    esv2656635CNV Deletion23128226
    esv1008863CNV Insertion20482838
    esv28523CNV Loss19812545
    nsv833465CNV Loss17160897
    nsv483083CNV Gain15286789
    nsv908562CNV Gain21882294
    nsv428343CNV Gain+Loss18775914
    dgv985e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): WNT3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WNT3
    DNA2.0 Custom Variant and Variant Library Synthesis for WNT3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 165330   
    OMIM disorders: 273395  
    UniProtKB/Swiss-Prot: WNT3_HUMAN, P56703
  • Tetraamelia, autosomal recessive (ARTTRA) [MIM:273395]: A rare human genetic disorder characterized by
    complete absence of all four limbs and other anomalies such as craniofacial, nervous system, pulmonary, skeletal
    and urogenital defects. Note=The disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for WNT3 (see all 33):    
    About MalaCards
    tetra-amelia syndrome    oral leukoplakia    progressive supranuclear palsy    leukoplakia
    cleft lip    mantle cell lymphoma    cleft palate    celiac disease
    basal cell carcinoma    hyperparathyroidism    labyrinthitis    multiple myeloma
    endometrial carcinoma    myeloma    kidney disease    parkinson's disease
    chronic lymphocytic leukemia    hepatitis b    hepatocellular carcinoma    colorectal cancer

    2 diseases from the University of Copenhagen DISEASES database for WNT3:
    Cleft lip     Cleft palate

    WNT3 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for WNT3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mammary tumor 52.2 2 8738604 (1), 8244403 (1)
    gastric cancer 32.6 3 11604997 (2), 11788904 (1)
    breast cancer 21.1 2 11604997 (1), 11788904 (1)
    cancer 20.4 4 11604997 (2), 11788904 (2)
    tumors 5.68 4 18313787 (2), 11788904 (1)
    necrosis 0 1 11788904 (1)

    GeneTests: WNT3
    GeneReviews: WNT3
    Genetic Association Database (GAD): WNT3
    Human Genome Epidemiology (HuGE) Navigator: WNT3 (8 documents)

    Export disorders for WNT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WNT3 gene, integrated from 10 sources (see all 68):
    (articles sorted by number of sources associating them with WNT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene. (PubMed id 8244403)1, 2, 3, 9 Roelink H.... Nusse R. (Genomics 1993)
    2. Molecular cloning and characterization of human WNT3. (PubMed id 11604997)1, 2, 9 Katoh M. (Int. J. Oncol. 2001)
    3. Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family. (PubMed id 14872406)1, 2, 9 Niemann S.... Mueller U. (Am. J. Hum. Genet. 2004)
    4. Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. (PubMed id 22451204)1, 4 Pankratz N....Foroud T. (Ann. Neurol. 2012)
    5. Genome-wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish population. (PubMed id 21812969)1, 4 Liu X....Lee J.H. (BMC Med. Genet. 2011)
    6. Multiple common variants for celiac disease influencing immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (Nat. Genet. 2010)
    7. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    8. Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate. (PubMed id 20672350)1, 4 Nikopensius T....Metspalu A. (Birth Defects Res. Part A Clin. Mol. Teratol. 2010)
    9. Studies with Wnt genes and nonsyndromic cleft lip and palate. (PubMed id 20890934)1, 4 Menezes R....Vieira A.R. (Birth Defects Res. Part A Clin. Mol. Teratol. 2010)
    10. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7473 HGNC: 12782 AceView: WNT3 Ensembl:ENSG00000108379 euGenes: HUgn7473
    ECgene: WNT3 Kegg: 7473 H-InvDB: WNT3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WNT3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT3 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=WNT3[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WNT3 gene:
    Search GeneIP for patents involving WNT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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