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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WNT3 Gene

protein-coding   GIFtS: 65
GCID: GC17M044839

Wingless-Type MMTV Integration Site Family, Member 3


(Previous symbol: INT4)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Wingless-Type MMTV Integration Site Family, Member 31 2
INT41 2 3 5
WNT-3 Proto-Oncogene Protein1 2
Proto-Oncogene Int-4 Homolog2 3
Proto-Oncogene Wnt-32

External Ids:    HGNC: 127821   Entrez Gene: 74732   Ensembl: ENSG000001083797   OMIM: 1653305   UniProtKB: P567033   

Export aliases for WNT3 gene to outside databases

Previous GC identifers: GC17M044339 GC17M047240 GC17M045183 GC17M045316 GC17M042196 GC17M040220


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WNT3 Gene:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These
proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell
fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein
which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene
product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the
gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and
gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with
WNT15, another family member, in the chromosome 17q21 region. (provided by RefSeq, Jul 2008)

GeneCards Summary for WNT3 Gene: 
WNT3 (wingless-type MMTV integration site family, member 3) is a protein-coding gene. Diseases associated with WNT3 include tetra-amelia syndrome, and oral leukoplakia, and among its related super-pathways are Basal cell carcinoma and Wnt Signaling Pathway. GO annotations related to this gene include receptor agonist activity and protein domain specific binding. An important paralog of this gene is WNT5B.

UniProtKB/Swiss-Prot: WNT3_HUMAN, P56703
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play
distinct roles in cell-cell signaling during morphogenesis of the developing neural tube (By similarity)

Gene Wiki entry for WNT3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WNT3 gene promoter:
         p53   Nkx2-5   HNF-4alpha2   GATA-2   E47   HNF-4alpha1   Pax-3   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWNT3 promoter sequence
   Search SABiosciences Chromatin IP Primers for WNT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WNT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21-q22

WNT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M044839:  view genomic region     (about GC identifiers)

Start:
44,839,872 bp from pter      End:
44,910,520 bp from pter
Size:
70,649 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WNT3_HUMAN, P56703 (See protein sequence)
Recommended Name: Proto-oncogene Wnt-3 precursor  
Size: 355 amino acids; 39645 Da
Subunit: Interacts with PORCN (By similarity). Interacts with WLS (By similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix
Secondary accessions: Q2M237 Q9H1J9

Explore the universe of human proteins at neXtProt for WNT3: NX_P56703

Explore proteomics data for WNT3 at MOPED 

Post-translational modifications:

  • UniProtKB: Palmitoylation at Ser-212 is required for efficient binding to frizzled receptors. It is also required for
    subsequent palmitoylation at Cys-80. Palmitoylation is necessary for proper trafficking to cell surface (By
    similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P56703

  • WNT3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WNT3 Protein Expression
    REFSEQ proteins: NP_110380.1  
    ENSEMBL proteins: 
     ENSP00000225512  
    Reactome Protein details: P56703
    Human Recombinant Protein Products for WNT3: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WNT3 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space TAS18313787
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005796Golgi lumen TAS--

    WNT3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands
    WNT: Wingless-type MMTV integration sites

    3 InterPro protein domains:
     IPR005817 Wnt
     IPR009141 Wnt3
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry P56703

    ProtoNet protein and cluster: P56703

    1 Blocks protein domain: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WNT3_HUMAN, P56703
    Similarity: Belongs to the Wnt family


    WNT3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WNT3_HUMAN, P56703
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play
    distinct roles in cell-cell signaling during morphogenesis of the developing neural tube (By similarity)

         Genatlas biochemistry entry for WNT3:
    wingless-type MMTV integration site 3,Drosophila wingless (wg) segment polarity gene homolog,expressed in
    developing nervous system and in adult thalamus,cerebellum,pons,modulating cell fate and cell behavior during
    vertebrate development,required for the primary axis formation

         Summary:
    During embryonic development, WNT3 as signaling molecule is secreted from the following cells: Extraembryonic Ectoderm Cells in Extraembryonic Ectoderm, Intraembryonic Epiblast Cells in Epiblast

    It affects the following cells: Intraembryonic Epiblast Cells in Epiblast, Melanocytes in Trunk Neural Crest (see all 3).

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005109frizzled binding IPI10557084
    GO:0005515protein binding ----
    GO:0019904protein domain specific binding IEA--
    GO:0048018receptor agonist activity IC18044981
         
    WNT3 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Wnt3):
     cellular  embryogenesis  growth/size  limbs/digits/tail  mortality/aging 
     no phenotypic analysis  normal 

    WNT3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for WNT3: Wnt3tm1Brd Wnt3tm1Amc

       inGenious Targeting Laboratory - Custom generated mouse model solutions for WNT3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for WNT3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WNT3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WNT3 

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    SwitchGear 3'UTR luciferase reporter plasmidWNT3 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for WNT3 About   (see all 23)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Basal cell carcinoma
    Hedgehog signaling pathway0.43
    Wnt Pathway0.39
    Basal cell carcinoma0.43
    Melanogenesis0.32
    2Wnt signaling pathway
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    3Wnt Signaling Pathway
    Wnt Signaling Pathway0.55
    DNA damage response (only ATM dependent)0.32
    Wnt Signaling Pathway and Pluripotency0.55
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    5Asparagine N-linked glycosylation
    WNT ligand biogenesis and trafficking0.77
    Signaling by Wnt0.62

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for WNT3
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for WNT3 (see all 9)
        G12-G13 in Cellular Signaling
    Colorectal Cancer Metastasis
    GSK3 Signaling
    Reelin Pathway (Cajal-Retzius cells)
    Presenilin-Mediated Signaling

    1 Tocris Bioscience Pathway for WNT3
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT3
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    5 BioSystems Pathways for WNT3
        Wnt Signaling Pathway
    DNA damage response (only ATM dependent)
    Wnt Signaling Pathway and Pluripotency
    Wnt Signaling Pathway NetPath
    Wnt signaling network

    2 Sino Biological Pathways for WNT3 
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    5/6        Reactome Pathways for WNT3 (see all 6)
        Signaling by Wnt
    Signal Transduction
    Signaling by GPCR
    WNT ligand biogenesis and trafficking
    GPCR ligand binding


    5/9         Kegg Pathways  (Kegg details for WNT3) (see all 9):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection


    WNT3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WNT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/24 Interacting proteins for WNT3 (P567033 ENSP000002255124) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FZD1Q9UP383, ENSP000002879344I2D: score=1 STRING: ENSP00000287934
    FZD7O750843, ENSP000002862014I2D: score=1 STRING: ENSP00000286201
    PORCNQ9H2373, ENSP000003223044I2D: score=3 STRING: ENSP00000322304
    KLQ9UEF73I2D: score=1 
    FZD5ENSP000003546074STRING: ENSP00000354607
    About this table

    Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis IMP15588944
    GO:0001707mesoderm formation IEA--
    GO:0007275multicellular organismal development ----
    GO:0007411axon guidance IEA--
    GO:0009948anterior/posterior axis specification IEA--

    WNT3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    WNT3 for compounds           About GeneDecksing

    EMD Millipore small molecules for WNT3:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WNT3

    1 Novoseek inferred chemical compound relationship for WNT3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 26.9 4 11788904 (2), 11786923 (1)

    Search CenterWatch for drugs/clinical trials and news about WNT3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WNT3 gene: 
    NM_030753.4  

    Unigene Cluster for WNT3:

    Wingless-type MMTV integration site family, member 3
    Hs.445884  [show with all ESTs]
    Unigene Representative Sequence: BC114219
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000225512(uc002ikv.2) ENST00000573788 ENST00000572508 ENST00000576471


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    Additional mRNA sequence: 

    AB067628.1 AY009397.1 BC112116.1 BC112118.1 BC114219.1 

    2 DOTS entries:

    DT.102839944  DT.405345 

    15 AceView cDNA sequences:

    AB067628 BX281024 AY009397 NM_030753 BF515681 CD632703 CD632710 CD632708 
    AI638412 CD632707 CD632706 AA634318 CD632709 CD632705 CD632704 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WNT3 expression in normal human tissues (normalized intensities)      WNT3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTTTTTTT
    WNT3 Expression
    About this image


    WNT3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Thalamus
             Midbrain   
     
     Hair
             Fetal Precortex Cells Hair Shaft
             mouse/organ system/integumental system   
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 3 entries
             Mesendoderm Cells Primitive Streak
             Mesendoderm-like cells ( Generation of beta cells through a definitive endoderm stage...
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Roof Plate Cells Spinal Roof Plate
             Diencephalon
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mandibular Process
             sensory organ/ear/inner ear   

    See WNT3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WNT3

    SOURCE GeneReport for Unigene cluster: Hs.445884
        SABiosciences Expression via Pathway-Focused PCR Arrays including WNT3: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for WNT3 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wnt31 , 5 wingless-related MMTV integration site 31, 5 92.49(n)1
    98.87(a)1
      11 (67.50 cM)5
    224151  NM_009521.21  NP_033547.11 
     1037741505 
    chicken
    (Gallus gallus)
    Aves WNT31 wingless-type MMTV integration site family, member 3 less 83.76(n)
    96.06(a)
      374142  NM_001081696.1  NP_001075165.1 
    lizard
    (Anolis carolinensis)
    Reptilia WNT36
    wingless-type MMTV integration site family, member...
    96(a)
    1 ↔ 1
    6(65550323-65582871)
    African clawed frog
    (Xenopus laevis)
    Amphibia wnt3a-A2 wingless-type MMTV integration site family, member 3 less 75.94(n)    L07538.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wnt31 wingless-type MMTV integration site family, member 3 less 77.56(n)
    89.58(a)
      569420  NM_001114552.1  NP_001108024.1 


    ENSEMBL Gene Tree for WNT3 (if available)
    TreeFam Gene Tree for WNT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WNT3 gene
    WNT5B2  WNT162  WNT62  WNT5A2  WNT112  WNT22  WNT2B2  WNT3A2  
    WNT12  WNT42  WNT10B2  WNT7A2  WNT7B2  WNT10A2  
    18 SIMAP similar genes for WNT3 using alignment to 1 protein entry:     WNT3_HUMAN:
    WNT3A    WNT4    WNT7B    WNT2    WNT1    WNT7A
    WNT2B    WNT5B    WNT11    WNT5A    WNT16    WNT6
    WNT8A    WNT8B    WNT10A    WNT9A    WNT9B    WNT10B

    WNT3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1108 SNPs in WNT3 are shown (see all 1108)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1048946531,2
    Cpathogenic145865408(-) AGCACC/TAGTTC 2 Q * stg10--------
    rs358620771,2
    C--40254817(+) TCTCAA/-AAAAA 1 -- int11Minor allele frequency- -:0.00NA 2
    rs58206221,2
    C--40256289(+) CTCTT-/AACACT 1 -- int11Minor allele frequency- A:0.00CSA 2
    rs80780291,2
    C,A--44839623(+) AGTACA/CCAAGT 1 -- ds50012Minor allele frequency- C:0.00NA 4
    rs1475008701,2
    C--44839655(+) ATTCAC/TTGTTA 1 -- ds50010--------
    rs760765731,2
    C,F--44839671(+) TAACTT/GAGAAC 1 -- ds50011Minor allele frequency- G:0.03NA 120
    rs346337431,2
    C,F,H--44841205(+) AAAAAA/CAAAAA 2 -- ut3114Minor allele frequency- C:0.21NS EA NA 1978
    rs353598011,2
    C,F,H--44841209(+) AAAAAA/CAAACA 2 -- ut318Minor allele frequency- C:0.13NS NA 1142
    rs2004675231,2
    C--44841209(+) AAAAAA/CAAACA 1 -- ut310--------
    rs733045151,2
    C,F--44856421(+) CCATCT/ACACAC 1 -- int12Minor allele frequency- A:0.33WA CSA 3

    HapMap Linkage Disequilibrium report for WNT3 (44839872 - 44910520 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for WNT3 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2659354CNV Deletion23128226
    esv1005788CNV Deletion20482838
    esv2656635CNV Deletion23128226
    esv1008863CNV Insertion20482838
    esv28523CNV Loss19812545
    nsv833465CNV Loss17160897
    nsv483083CNV Gain15286789
    nsv908562CNV Gain21882294
    nsv428343CNV Gain+Loss18775914
    dgv985e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): WNT3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing WNT3
    DNA2.0 Custom Variant and Variant Library Synthesis for WNT3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 165330   
    OMIM disorders: 273395  
    UniProtKB/Swiss-Prot: WNT3_HUMAN, P56703
  • Tetraamelia, autosomal recessive (ARTTRA) [MIM:273395]: A rare human genetic disorder characterized by
    complete absence of all four limbs and other anomalies such as craniofacial, nervous system, pulmonary, skeletal
    and urogenital defects. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 20/29 diseases for WNT3 (see all 29):    About MalaCards
    tetra-amelia syndrome    oral leukoplakia    progressive supranuclear palsy    gastric cancer
    leukoplakia    cleft lip    mantle cell lymphoma    cleft palate
    celiac disease    hyperparathyroidism    basal cell carcinoma    endometrial carcinoma
    multiple myeloma    kidney disease    parkinson's disease    chronic lymphocytic leukemia
    myeloma    ovarian cancer    hepatitis b    hepatocellular carcinoma

    2 diseases from the University of Copenhagen DISEASES database for WNT3:
    Cleft lip     Cleft palate

    WNT3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    6 Novoseek inferred disease relationships for WNT3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mammary tumor 52.2 2 8738604 (1), 8244403 (1)
    gastric cancer 32.6 3 11604997 (2), 11788904 (1)
    breast cancer 21.1 2 11604997 (1), 11788904 (1)
    cancer 20.4 4 11604997 (2), 11788904 (2)
    tumors 5.68 4 18313787 (2), 11788904 (1)
    necrosis 0 1 11788904 (1)

    GeneTests: WNT3
    GeneReviews: WNT3
    Genetic Association Database (GAD): WNT3
    Human Genome Epidemiology (HuGE) Navigator: WNT3 (8 documents)

    Export disorders for WNT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WNT3 gene, integrated from 9 sources (see all 69):
    (articles sorted by number of sources associating them with WNT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene. (PubMed id 8244403)1, 2, 3, 9 Roelink H.... Nusse R. (1993)
    2. Molecular cloning and characterization of human WNT3. (PubMed id 11604997)1, 2, 9 Katoh M. (2001)
    3. Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family. (PubMed id 14872406)1, 2, 9 Niemann S.... Mueller U. (2004)
    4. Meta-analysis of Parkinson's disease: identification o f a novel locus, RIT2. (PubMed id 22451204)1, 4 Pankratz N....Foroud T. (2012)
    5. Genome-wide association study identifies candidate gen es for Parkinson's disease in an Ashkenazi Jewish population. (PubMed id 21812969)1, 4 Liu X....Lee J.H. (2011)
    6. Multiple common variants for celiac disease influenci ng immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (2010)
    7. Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (2010)
    8. Genetic variants in COL2A1, COL11A2, and IRF6 contrib ute risk to nonsyndromic cleft palate. (PubMed id 20672350)1, 4 Nikopensius T....Metspalu A. (2010)
    9. Studies with Wnt genes and nonsyndromic cleft lip and palate. (PubMed id 20890934)1, 4 Menezes R....Vieira A.R. (2010)
    10. Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7473 HGNC: 12782 AceView: WNT3 Ensembl:ENSG00000108379 euGenes: HUgn7473
    ECgene: WNT3 Kegg: 7473 H-InvDB: WNT3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WNT3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT3 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/WNT3

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WNT3 gene:
    Search GeneIP for patents involving WNT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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