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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

WNT3 Gene

protein-coding GIFtS: 65
GCID: GC17M044839

wingless-type MMTV integration site family, member 3

(Previous symbol: INT4)

Explore 34 diseases affiliated with
WNT3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Wingless-Type MMTV Integration Site Family, Member 3¹ ²		MGC138321¹
INT4¹ ² ³ ⁵		MGC138323¹
Proto-Oncogene Int-4 Homolog² ³		Proto-Oncogene Wnt-3²
MGC131950¹		WNT-3 Proto-Oncogene Protein²

External Ids:	HGNC: 12782¹	Entrez Gene: 7473²	Ensembl: ENSG00000108379⁷	OMIM: 165330⁵	UniProtKB: P56703³

Export aliases for WNT3 gene to outside databases

Previous GC identifers: GC17M044339 GC17M047240 GC17M045183 GC17M045316 GC17M042196 GC17M040220

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WNT3:

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins

have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and

patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98%

amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies

show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this

gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the

WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome

17q21 region. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: WNT3_HUMAN, P56703

Function: Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct

roles in cell-cell signaling during morphogenesis of the developing neural tube (By similarity)

Gene Wiki entry for WNT3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the WNT3 gene promoter:
p53 Nkx2-5 HNF-4alpha2 GATA-2 E47 HNF-4alpha1 Pax-3 PPAR-gamma1 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WNT3 promoter sequence

Search SABiosciences Chromatin IP Primers for WNT3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WNT3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21 Ensembl cytogenetic band: 17q21.32 HGNC cytogenetic band: 17q21-q22

WNT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT3 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M044839: view genomic region (about GC identifiers)

Start:	44,839,872 bp from pter	End:	44,910,520 bp from pter
Size:	70,649 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: WNT3_HUMAN, P56703 (See protein sequence)

Recommended Name: Proto-oncogene Wnt-3 precursor

Size: 355 amino acids; 39645 Da

Subunit: Interacts with PORCN (By similarity). Interacts with WLS (By similarity)

Subcellular location: Secreted, extracellular space, extracellular matrix

Secondary accessions: Q2M237 Q9H1J9

Explore the universe of human proteins at neXtProt for WNT3: NX_P56703

Post-translational modifications:

Palmitoylation at Ser-212 is required for efficient binding to frizzled receptors. It is also required for subsequent

palmitoylation at Cys-80. Palmitoylation is necessary for proper trafficking to cell surface (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P56703

WNT3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_110380.1

ENSEMBL proteins:

ENSP00000225512

Reactome Protein details: P56703
Human Recombinant Protein Products:

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	Uscn Proteins for WNT3

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005615	extracellular space	TAS	18313787
GO:0005624	membrane fraction	--	--
GO:0005737	cytoplasm	--	--
GO:0005769	early endosome	IBA	--

WNT3 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for WNT3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

WNT3 for domains About GeneDecksing

3 InterPro domains/families:

IPR005817 Wnt

IPR009141 Wnt3

IPR018161 Wnt_CS

Graphical View of Domain Structure for InterPro Entry P56703

ProtoNet protein and cluster: P56703

1 Blocks protein family: IPB005816 Secreted growth factor Wnt protein

UniProtKB/Swiss-Prot: WNT3_HUMAN, P56703

Similarity: Belongs to the Wnt family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: WNT3_HUMAN, P56703

Function: Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct

roles in cell-cell signaling during morphogenesis of the developing neural tube (By similarity)

Genatlas biochemistry entry for WNT3:

wingless-type MMTV integration site 3,Drosophila wingless (wg) segment polarity gene homolog,expressed in developing

nervous system and in adult thalamus,cerebellum,pons,modulating cell fate and cell behavior during vertebrate

development,required for the primary axis formation

Summary:

During embryonic development, WNT3 as signaling molecule is secreted from the following cells: Extraembryonic Ectoderm Cells in Extraembryonic Ectoderm, Intraembryonic Epiblast Cells in Epiblast

It affects the following cells: Intraembryonic Epiblast Cells in Epiblast, Melanocytes in Trunk Neural Crest (see all 3).

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		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate WNT3 (see all 10):
		hsa-miR-362-3p hsa-miR-520a-5p hsa-miR-329 hsa-miR-19b hsa-miR-525-5p hsa-miR-518a-5p hsa-miR-3143 hsa-miR-3925-5p

		SwitchGear 3'UTR luciferase reporter plasmid: WNT3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT3

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005109	frizzled binding	IPI	18313787
GO:0005110	frizzled-2 binding	IBA	--
GO:0005515	protein binding	--	--
GO:0019904	protein domain specific binding	IEA	--
GO:0048018	receptor agonist activity	IC	18044981

WNT3 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for WNT3: Wnt3^tm1Brd Wnt3^tm1Amc
     7 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Wnt3):

cellular	embryogenesis	growth/size	limbs/digits/tail	mortality/aging
no phenotypic analysis	normal

WNT3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Wnt Signaling Pathway

Wnt Signaling Pathway	1.00	Wnt signaling pathway	0.30
Wnt Signaling Pathway and Pluripotency	0.55	Wnt Signaling Pathway NetPath	0.22
DNA damage response (only ATM dependent)	0.35

Basal cell carcinoma

	Basal cell carcinoma	1.00			Wnt Pathway	0.37
	Hedgehog signaling pathway	0.41			Melanogenesis	0.32

Translation_Non-genomic (rapid) action of Androgen Receptor

Translation_Non-genomic (rapid) action of Androgen Receptor

1.00

Translation Non-genomic (rapid) action of Androgen Receptor

0.99

Transcription_Androgen Receptor nuclear signaling

Transcription_Androgen Receptor nuclear signaling

1.00

Transcription Androgen Receptor nuclear signaling

0.99

Nanog in Mammalian ESC Pluripotency

Nanog in Mammalian ESC Pluripotency

1.00

GSK3 Signaling

0.61

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for WNT3

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for WNT3 (see all 9)

	G12-G13 in Cellular Signaling
	Colorectal Cancer Metastasis
	GSK3 Signaling
	Reelin Pathway (Cajal-Retzius cells)
	Presenilin-Mediated Signaling

1 Tocris Bioscience Pathway for WNT3

Wnt Pathway

2 GeneGo (Thomson Reuters) Pathways for WNT3

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

5 BioSystems Pathways for WNT3

	Wnt Signaling Pathway
	Wnt Signaling Pathway and Pluripotency
	DNA damage response (only ATM dependent)
	Wnt Signaling Pathway NetPath
	Wnt signaling network

4 Reactome Pathways for WNT3

	Signal Transduction
	Signaling by GPCR
	GPCR ligand binding
	Class B/2 (Secretin family receptors)

5 Kegg Pathways (Kegg details for WNT3):

	Wnt signaling pathway
	Hedgehog signaling pathway
	Melanogenesis
	Pathways in cancer
	Basal cell carcinoma

WNT3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for WNT3

STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

5/24 Interacting proteins for WNT3 (P56703³ ENSP00000225512⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 24)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FZD1	Q9UP38³, ENSP00000287934⁴	I2D: score=1 STRING: ENSP00000287934
FZD7	O75084³, ENSP00000286201⁴	I2D: score=1 STRING: ENSP00000286201
PORCN	Q9H237³, ENSP00000322304⁴	I2D: score=3 STRING: ENSP00000322304
KL	Q9UEF7³	I2D: score=1
FZD5	ENSP00000354607⁴	STRING: ENSP00000354607

About this table

Gene Ontology (GO): 5/30 biological process terms (GO ID links to tree view) (see all 30): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000902	cell morphogenesis	IMP	15588944
GO:0001707	mesoderm formation	IBA	--
GO:0007165	signal transduction	--	--
GO:0007223	Wnt receptor signaling pathway, calcium modulating pathway	IBA	--
GO:0007411	axon guidance	IEA	--

WNT3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

WNT3 for compounds About GeneDecksing

EMD Millipore small molecules for WNT3:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for WNT3
1 Novoseek chemical compound relationship for WNT3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoic acid	26.9	4	11788904 (2), 11786923 (1)

Search CenterWatch for drugs/clinical trials and news about WNT3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for WNT3 gene:

NM_030753.3

Unigene Cluster for WNT3:

Wingless-type MMTV integration site family, member 3

Hs.445884 [show with all ESTs]

Unigene Representative Sequence: BC114219

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000225512(uc002ikv.2) ENST00000573788 ENST00000572508 ENST00000576471

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WNT3
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		hsa-miR-362-3p hsa-miR-520a-5p hsa-miR-329 hsa-miR-19b hsa-miR-525-5p hsa-miR-518a-5p hsa-miR-3143 hsa-miR-3925-5p

		SwitchGear 3'UTR luciferase reporter plasmid: WNT3 3' UTR sequence

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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WNT3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WNT3 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Additional cDNA sequence:

AB067628.1 AY009397.1 BC112116.1 BC112118.1 BC114219.1

2 DOTS entries:

DT.102839944 DT.405345

15 AceView cDNA sequences:

BX281024 AB067628 AY009397 NM_030753 CD632706 BF515681 CD632707 CD632708

AI638412 CD632710 CD632703 CD632705 AA634318 CD632709 CD632704

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

WNT3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGTTTTTTT

About this image

WNT3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

7 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ectoderm

Intraembryonic Ectoderm Cells

Early Embryo, Ectoderm

Epiblast

Intraembryonic Epiblast Cells

Early Embryo

Mesoderm

Mesoderm Cells

Early Embryo, Mesoderm

Primitive Streak

Mesendoderm Cells

Early Embryo

Primitive Streak

Primitive Streak Cells

Early Embryo

Trophoblast

Extraembryonic Ectoderm

Extraembryonic Ectoderm Cells

Extraembryonic Tissues, Placenta

Liver

Hepatic Mesenchyme

Mesothelial Cells

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Mesendoderm-like cells (Generation of beta c...)

Epiblast-like cells (Reconstitution of mo...)

Definitive endoderm-like cells (A scalable, suspensi...)

See WNT3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WNT3

SOURCE GeneReport for Unigene cluster: Hs.445884

SABiosciences Expression via Pathway-Focused PCR Arrays including WNT3:

Hedgehog Signaling Pathway in human mouse rat

WNT Signaling Pathway in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WNT3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for WNT3 gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	WNT3¹	wingless-type MMTV integration site family, member 3 less	83.76(n) 96.06(a)		374142 NM_001081696.1 NP_001075165.1
lizard (Anolis carolinensis)	Reptilia	WNT3⁶	--	93(a)	1 ↔ 1	6(65550331-65558891)
African clawed frog (Xenopus laevis)	Amphibia	wnt3a-A²	wingless-type MMTV integration site family, member 3 less	75.94(n)		L07538.1
zebrafish (Danio rerio)	Actinopterygii	wnt3¹	wingless-type MMTV integration site family, member 3 less	77.56(n) 89.58(a)		569420 NM_001114552.1 NP_001108024.1

ENSEMBL Gene Tree for WNT3 (if available)
TreeFam Gene Tree for WNT3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for WNT3 gene

WNT5B² WNT16² WNT5A² WNT6² WNT11² WNT2² WNT2B² WNT3A²

WNT1² WNT10B² WNT4² WNT7A² WNT7B² WNT10A²

18 SIMAP similar genes for WNT3 using alignment to 1 protein entry: WNT3_HUMAN:

WNT3A WNT4 WNT7B WNT2 WNT1 WNT7A

WNT2B WNT5B WNT11 WNT5A WNT16 WNT6

WNT8A WNT8B WNT10A WNT9A WNT9B WNT10B

WNT3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs34633743^1,2	C,F,H	--	40219574(+)	`AAAAAA/CAAAAA`	1	--	ds500¹		14	NS EA NA	1978
rs35359801^1,2	C,F,H	--	40219578(+)	`AAAAAA/CAAACA`	1	--	ds500¹		8	NS NA	1142
rs73987025^1,2	C,	--	40219662(+)	`CCCTCG/ATGCAG`	1	--	ds500¹		1	WA	2
rs9908452^1,2	C,H,	--	40220155(+)	`ATCCAG/CAGTAG`	1	--	ut3¹ ese³		5	NS EA WA	532
rs4968240^1,2	H	--	40220750(+)	`TTTGTA/GCCGCA`	1	--	int¹		1	NS	120
rs77790426^1,2	F,	--	40220759(+)	`CACCAA/GATAGC`	1	--	int¹		1	WA	118
rs199528^1,2	C,F,H,	--	40221505(+)	`GTGAGC/TAGCTG`	1	--	int¹		9	NS EA NA	546
rs60837808^1,2	C,F,	--	40221618(+)	`TCAGCG/AAGGCA`	1	--	int¹		3	WA CSA	122
rs9905415^1,2	C,F,H,	--	40222979(+)	`CCACCC/TGCCTT`	1	--	int¹		5	NS NA	792
rs77266163^1,2	F,	--	40223907(+)	`CCTAGC/TTTCCT`	1	--	int¹		1	NA	120

HapMap Linkage Disequilibrium report for WNT3 (44839872 - 44910520 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for WNT3
6 CNVs: 72960 5014 3147 34570 0207 4038
Human Gene Mutation Database (HGMD): WNT3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

WNT3 for disorders           About GeneDecksing

OMIM gene information: 165330
OMIM disorders: 273395
UniProtKB/Swiss-Prot: WNT3_HUMAN, P56703

Defects in WNT3 are the cause of autosomal recessive tetra-amelia (ARTTRA) [MIM:273395]. Tetra-amelia is a

rare human genetic disorder characterized by complete absence of all four limbs and other anomalies such as

craniofacial, nervous system, pulmonary, skeletal and urogenital defects

20/34 diseases for WNT3 (see all 34): About MalaCards

tetra-amelia gastric cancer cleft lip/palate supranuclear palsy

progressive supranuclear palsy cleft lip oral leukoplakia mantle cell lymphoma

leukoplakia cleft palate basal cell carcinoma chronic lymphocytic leukemia

breast-ovarian cancer lymphocytic leukemia celiac disease multiple myeloma

ovarian cancer endometrial carcinoma hepatitis b kidney disease

2 diseases from the University of Copenhagen DISEASES database for WNT3:

Cleft lip Cleft palate

6 Novoseek disease relationships for WNT3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mammary tumor	52.2	2	8738604 (1), 8244403 (1)
gastric cancer	32.6	3	11604997 (2), 11788904 (1)
breast cancer	21.1	2	11604997 (1), 11788904 (1)
cancer	20.4	4	11604997 (2), 11788904 (2)
tumors	5.68	4	18313787 (2), 11788904 (1)
necrosis	0	1	11788904 (1)

GeneTests: WNT3

Tetra-Amelia Syndrome

Genetic Association Database (GAD): WNT3
Human Genome Epidemiology (HuGE) Navigator: WNT3 (8 documents)

Export disorders for WNT3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for WNT3 gene, integrated from 9 sources (see all 68):
(articles sorted by number of sources associating them with WNT3)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene. (PubMed id 8244403)^{1, 2, 3, 9} Roelink H.... Nusse R. (1993)
Molecular cloning and characterization of human WNT3. (PubMed id 11604997)^{1, 2, 9} Katoh M. (2001)
Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family. (PubMed id 14872406)^{1, 2, 9} Niemann S.... Mueller U. (2004)
Novel haplotypes in 17q21 are associated with progressive supranuclear palsy. (PubMed id 15293277)^{1, 4} Pastor P....Goate A.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Regulation of WNT3 and WNT3A mRNAs in human cancer cell lines NT2, MCF-7, and MKN45. (PubMed id 11788904)^{1, 9} Katoh M. (2002)
Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. (PubMed id 18313787)^{1, 9} Kim M....Wands J.R. (2008)
Wnt3 modulates the characteristics and cobblestone area-supporting activity of human stromal cells. (PubMed id 15588944)^{1, 9} Chiba H....Niitsu Y. (2004)
Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. (PubMed id 8168088)^{1, 9} Huguet E.L.... Harris A.L. (1994)
Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma. (PubMed id 18787224)^{1, 9} Gelebart P....Lai R. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7473	HGNC: 12782	AceView: WNT3	Ensembl:ENSG00000108379	euGenes: HUgn7473
ECgene: WNT3	Kegg: 7473	H-InvDB: WNT3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for WNT3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for WNT3	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/WNT3

Intellectual Property for WNT3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for WNT3 gene:
Search GeneIP for patents involving WNT3

GeneCards and IP:
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wingless-type MMTV integration site family, member 3

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wingless-type MMTV integration site family, member 3

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