Aliases for WNT3 Gene
External Ids for WNT3 Gene
Previous HGNC Symbols for WNT3 Gene
Previous GeneCards Identifiers for WNT3 Gene
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008]
GeneCards Summary for WNT3 Gene
WNT3 (Wingless-Type MMTV Integration Site Family, Member 3) is a Protein Coding gene. Diseases associated with WNT3 include tetra-amelia syndrome and tetraamelia multiple malformations x-linked. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include protein domain specific binding and receptor agonist activity. An important paralog of this gene is WNT1.
UniProtKB/Swiss-Prot for WNT3 Gene
Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube (By similarity).