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Aliases for WNT3 Gene

Aliases for WNT3 Gene

  • Wnt Family Member 3 2 3
  • Wingless-Type MMTV Integration Site Family, Member 3 2 3
  • Wingless-Type MMTV Integration Site Family Member 3 3 5
  • WNT-3 Proto-Oncogene Protein 2 3
  • Proto-Oncogene Int-4 Homolog 3 4
  • INT4 3 4
  • TETAMS 3

External Ids for WNT3 Gene

Previous HGNC Symbols for WNT3 Gene

  • INT4

Previous GeneCards Identifiers for WNT3 Gene

  • GC17M044339
  • GC17M047240
  • GC17M045183
  • GC17M045316
  • GC17M042196
  • GC17M044839
  • GC17M040220

Summaries for WNT3 Gene

Entrez Gene Summary for WNT3 Gene

  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT3 Gene

WNT3 (Wnt Family Member 3) is a Protein Coding gene. Diseases associated with WNT3 include tetra-amelia syndrome and tetraamelia-multiple malformations syndrome. Among its related pathways are Basal cell carcinoma and Hippo signaling pathway. GO annotations related to this gene include receptor binding and frizzled binding. An important paralog of this gene is WNT5B.

UniProtKB/Swiss-Prot for WNT3 Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube (By similarity).

Gene Wiki entry for WNT3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT3 Gene

Genomics for WNT3 Gene

Regulatory Elements for WNT3 Gene

Enhancers for WNT3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WNT3 on UCSC Golden Path with GeneCards custom track

Genomic Location for WNT3 Gene

Chromosome:
17
Start:
46,762,506 bp from pter
End:
46,833,154 bp from pter
Size:
70,649 bases
Orientation:
Minus strand

Genomic View for WNT3 Gene

Genes around WNT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT3 Gene

Proteins for WNT3 Gene

  • Protein details for WNT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56703-WNT3_HUMAN
    Recommended name:
    Proto-oncogene Wnt-3
    Protein Accession:
    P56703
    Secondary Accessions:
    • Q2M237
    • Q9H1J9

    Protein attributes for WNT3 Gene

    Size:
    355 amino acids
    Molecular mass:
    39645 Da
    Quaternary structure:
    • Interacts with PORCN. Interacts with WLS.

neXtProt entry for WNT3 Gene

Proteomics data for WNT3 Gene at MOPED

Post-translational modifications for WNT3 Gene

  • Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at Asn 90 and Asn 301
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for WNT3 Gene

Domains & Families for WNT3 Gene

Gene Families for WNT3 Gene

Protein Domains for WNT3 Gene

Suggested Antigen Peptide Sequences for WNT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56703

UniProtKB/Swiss-Prot:

WNT3_HUMAN :
  • Belongs to the Wnt family.
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT3: view

Function for WNT3 Gene

Molecular function for WNT3 Gene

GENATLAS Biochemistry:
wingless-type MMTV integration site 3,Drosophila wingless (wg) segment polarity gene homolog,expressed in developing nervous system and in adult thalamus,cerebellum,pons,modulating cell fate and cell behavior during vertebrate development,required for the primary axis formation
UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube (By similarity).

LifeMap Function Summary for WNT3 Gene

During embryonic development, WNT3 as signaling molecule is secreted from the following cells
It affects the following cells:

Gene Ontology (GO) - Molecular Function for WNT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
genes like me logo Genes that share ontologies with WNT3: view
genes like me logo Genes that share phenotypes with WNT3: view

Human Phenotype Ontology for WNT3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for WNT3 Gene

MGI Knock Outs for WNT3:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for WNT3 Gene

Localization for WNT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT3 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WNT3 Gene COMPARTMENTS Subcellular localization image for WNT3 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
golgi apparatus 4
plasma membrane 4
nucleus 2
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for WNT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0030666 endocytic vesicle membrane TAS --
genes like me logo Genes that share ontologies with WNT3: view

Pathways & Interactions for WNT3 Gene

genes like me logo Genes that share pathways with WNT3: view

SIGNOR curated interactions for WNT3 Gene

Activates:

Gene Ontology (GO) - Biological Process for WNT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IMP 15588944
GO:0007275 multicellular organism development IEA --
GO:0007411 axon guidance IEA --
GO:0009950 dorsal/ventral axis specification IEA --
GO:0009952 anterior/posterior pattern specification IEA --
genes like me logo Genes that share ontologies with WNT3: view

Drugs & Compounds for WNT3 Gene

(6) Drugs for WNT3 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FH535 Pharma Wnt/B-catenin inhibitor 0
IWR-1-endo Pharma Potent Wnt signaling inhibitor 0
Kartogenin Pharma 0
KY 02111 Pharma WNT signaling inhibitor 0
LGK-974 Pharma PORCN inhibitor,potent and specific 0

(1) Additional Compounds for WNT3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(6) ApexBio Compounds for WNT3 Gene

Compound Action Cas Number
FH535 Wnt/B-catenin inhibitor 108409-83-2
IWR-1-endo Potent Wnt signaling inhibitor 1127442-82-3
Kartogenin 4727-31-5
KY 02111 WNT signaling inhibitor 1118807-13-8
LGK-974 PORCN inhibitor,potent and specific 1243244-14-5
Wnt-C59 PORCN inhibitor,highly potent and selective 1243243-89-1
genes like me logo Genes that share compounds with WNT3: view

Transcripts for WNT3 Gene

mRNA/cDNA for WNT3 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WNT3 Gene

Wingless-type MMTV integration site family, member 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WNT3 Gene

No ASD Table

Relevant External Links for WNT3 Gene

GeneLoc Exon Structure for
WNT3
ECgene alternative splicing isoforms for
WNT3

Expression for WNT3 Gene

mRNA expression in normal human tissues for WNT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT3 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x9.3), Skin - Sun Exposed (Lower leg) (x6.9), and Liver (x5.3).

Protein differential expression in normal tissues from HIPED for WNT3 Gene

This gene is overexpressed in Liver, secretome (65.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WNT3 Gene



SOURCE GeneReport for Unigene cluster for WNT3 Gene Hs.445884

genes like me logo Genes that share expression patterns with WNT3: view

Protein tissue co-expression partners for WNT3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for WNT3 Gene

Orthologs for WNT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WNT3 35
  • 92.58 (n)
  • 99.15 (a)
WNT3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WNT3 35
  • 93.8 (n)
  • 99.44 (a)
WNT3 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wnt3 35
  • 92.49 (n)
  • 98.87 (a)
Wnt3 16
Wnt3 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WNT3 35
  • 99.62 (n)
  • 100 (a)
WNT3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wnt3 35
  • 91.92 (n)
  • 98.87 (a)
oppossum
(Monodelphis domestica)
Mammalia WNT3 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves WNT3 35
  • 83.76 (n)
  • 96.06 (a)
WNT3 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WNT3 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wnt3 35
  • 78.73 (n)
  • 94.07 (a)
African clawed frog
(Xenopus laevis)
Amphibia wnt3a-A 35
zebrafish
(Danio rerio)
Actinopterygii wnt3 35
  • 78.66 (n)
  • 92.63 (a)
wnt3 36
  • 90 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Wnt2 37
  • 46 (a)
Wnt5 37
  • 41 (a)
Wnt6 37
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea cwn-1 37
  • 42 (a)
egl-20 37
  • 35 (a)
lin-44 37
  • 31 (a)
cwn-1 36
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for WNT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT3 Gene

ENSEMBL:
Gene Tree for WNT3 (if available)
TreeFam:
Gene Tree for WNT3 (if available)

Paralogs for WNT3 Gene

(18) SIMAP similar genes for WNT3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WNT3: view

Variants for WNT3 Gene

Sequence variations from dbSNP and Humsavar for WNT3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs70600 -- 46,782,655(+) GTGCA(C/T)ACCGT intron-variant
rs70602 -- 46,782,349(+) ATTTT(C/T)CTCTC intron-variant
rs111769 -- 46,794,621(+) TCTCA(C/T)ACCAG intron-variant
rs175243 -- 46,793,362(+) AAGGA(A/G)AAAGG intron-variant
rs175244 -- 46,793,538(+) CCCAC(C/G)CCCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WNT3 Gene

Variant ID Type Subtype PubMed ID
dgv974e1 CNV Complex 17122850
dgv975e1 CNV Complex 17122850
dgv976e1 CNV Complex 17122850
esv2656635 CNV Deletion 23128226
dgv985e1 CNV Complex 17122850
nsv428343 CNV Gain+Loss 18775914
nsv833465 CNV Loss 17160897
nsv483083 CNV Gain 15286789
nsv908562 CNV Gain 21882294
esv28523 CNV Loss 19812545
esv1005788 CNV Deletion 20482838
esv1008863 CNV Insertion 20482838
esv2659354 CNV Deletion 23128226

Variation tolerance for WNT3 Gene

Residual Variation Intolerance Score: 16.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.20; 4.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WNT3 Gene

HapMap Linkage Disequilibrium report
WNT3
Human Gene Mutation Database (HGMD)
WNT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT3 Gene

Disorders for WNT3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for WNT3 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
tetra-amelia syndrome
  • tetra-amelia
tetraamelia-multiple malformations syndrome
  • zimmer phocomelia
exstrophy of the bladder
  • bladder exstrophy
klatskin's tumor
  • hilar cholangiocarcinoma
- elite association - COSMIC cancer census association via MalaCards
Search WNT3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

WNT3_HUMAN
  • Tetraamelia syndrome, autosomal recessive (TETAMS) [MIM:273395]: A rare human genetic disorder characterized by complete absence of all four limbs and other anomalies such as craniofacial, nervous system, pulmonary, skeletal and urogenital defects. {ECO:0000269 PubMed:14872406}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for WNT3

Genetic Association Database (GAD)
WNT3
Human Genome Epidemiology (HuGE) Navigator
WNT3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WNT3
genes like me logo Genes that share disorders with WNT3: view

No data available for Genatlas for WNT3 Gene

Publications for WNT3 Gene

  1. Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene. (PMID: 8244403) Roelink H. … Nusse R. (Genomics 1993) 2 3 4 23 67
  2. Wnt3-frizzled 1 chimera as a model to study canonical Wnt signaling. (PMID: 20039315) Bhat R.A. … Bodine P.V. (J. Cell. Biochem. 2010) 3 23
  3. Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. (PMID: 18313787) Kim M. … Wands J.R. (J. Hepatol. 2008) 3 23
  4. Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma. (PMID: 18787224) Gelebart P. … Lai R. (Blood 2008) 3 23
  5. Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family. (PMID: 14872406) Niemann S. … Mueller U. (Am. J. Hum. Genet. 2004) 3 23

Products for WNT3 Gene

  • Addgene plasmids for WNT3

Sources for WNT3 Gene

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