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Aliases for WNT2B Gene

Aliases for WNT2B Gene

  • Wingless-Type MMTV Integration Site Family, Member 2B 2 3
  • WNT13 3 4 6
  • XWNT2 2 6
  • Wingless-Type MMTV Integration Site Family, Member 13 3
  • Wingless-Type MMTV Integration Site Family 2
  • XWNT2, Xenopus, Homolog Of 3
  • Protein Wnt-2b 3
  • Protein Wnt-13 4
  • Homolog Of 2
  • Member 13 2
  • Xenopus 2

External Ids for WNT2B Gene

Previous HGNC Symbols for WNT2B Gene

  • WNT13

Previous GeneCards Identifiers for WNT2B Gene

  • GC01P113426
  • GC01P111881
  • GC01P112112
  • GC01P112308
  • GC01P112722
  • GC01P112810
  • GC01P113009
  • GC01P110867

Summaries for WNT2B Gene

Entrez Gene Summary for WNT2B Gene

  • This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GeneCards Summary for WNT2B Gene

WNT2B (Wingless-Type MMTV Integration Site Family, Member 2B) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include frizzled binding. An important paralog of this gene is WNT1.

UniProtKB/Swiss-Prot for WNT2B Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May be involved in normal development or differentiation as well as in carcinogenesis

Gene Wiki entry for WNT2B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT2B Gene

Genomics for WNT2B Gene

Regulatory Elements for WNT2B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WNT2B Gene

Start:
112,466,541 bp from pter
End:
112,530,165 bp from pter
Size:
63,625 bases
Orientation:
Plus strand

Genomic View for WNT2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WNT2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT2B Gene

Proteins for WNT2B Gene

  • Protein details for WNT2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93097-WNT2B_HUMAN
    Recommended name:
    Protein Wnt-2b
    Protein Accession:
    Q93097
    Secondary Accessions:
    • O14903
    • Q5TEH9
    • Q5TEI2
    • Q9HDC1
    • Q9HDC2

    Protein attributes for WNT2B Gene

    Size:
    391 amino acids
    Molecular mass:
    43770 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WNT2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WNT2B Gene

Proteomics data for WNT2B Gene at MOPED

Post-translational modifications for WNT2B Gene

  • Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at Asn117 and Asn283
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT2B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for WNT2B Gene

Domains for WNT2B Gene

Gene Families for WNT2B Gene

HGNC:
  • WNT :Wingless-type MMTV integration sites

Protein Domains for WNT2B Gene

Suggested Antigen Peptide Sequences for WNT2B Gene

Graphical View of Domain Structure for InterPro Entry

Q93097

UniProtKB/Swiss-Prot:

WNT2B_HUMAN :
  • Q93097
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT2B: view

Function for WNT2B Gene

Molecular function for WNT2B Gene

GENATLAS Biochemistry: wingless type 2B,Drosophila wingless (wg),segment polarity gene homolog,expressed in breast,gastric cancer,modulating cell fate and cell behavior during vertebrate development
UniProtKB/Swiss-Prot Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May be involved in normal development or differentiation as well as in carcinogenesis

Gene Ontology (GO) - Molecular Function for WNT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding --
GO:0005109 frizzled binding IBA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with WNT2B: view

Phenotypes for WNT2B Gene

MGI mutant phenotypes for WNT2B:
inferred from 2 alleles
GenomeRNAi human phenotypes for WNT2B:
genes like me logo Genes that share phenotypes with WNT2B: view

Animal Models for WNT2B Gene

MGI Knock Outs for WNT2B:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for WNT2B Gene

Localization for WNT2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT2B Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WNT2B Gene COMPARTMENTS Subcellular localization image for WNT2B gene
Compartment Confidence
extracellular 5
plasma membrane 3
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for WNT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space NAS 15135146
genes like me logo Genes that share ontologies with WNT2B: view

Pathways for WNT2B Gene

genes like me logo Genes that share pathways with WNT2B: view

PCR Array Products

Gene Ontology (GO) - Biological Process for WNT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002062 chondrocyte differentiation IEP 15135146
GO:0002088 lens development in camera-type eye ISS 16258938
GO:0007275 multicellular organismal development --
GO:0008584 male gonad development IEP 17848411
GO:0009267 cellular response to starvation IEA --
genes like me logo Genes that share ontologies with WNT2B: view

Transcripts for WNT2B Gene

Unigene Clusters for WNT2B Gene

Wingless-type MMTV integration site family, member 2B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WNT2B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for WNT2B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WNT2B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: - -
SP3:

Relevant External Links for WNT2B Gene

GeneLoc Exon Structure for
WNT2B
ECgene alternative splicing isoforms for
WNT2B

Expression for WNT2B Gene

mRNA expression in normal human tissues for WNT2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for WNT2B Gene

SOURCE GeneReport for Unigene cluster for WNT2B Gene Hs.258575

mRNA Expression by UniProt/SwissProt for WNT2B Gene

Q93097-WNT2B_HUMAN
Tissue specificity: Isoform 1 is expressed in adult heart, brain, placenta, lung, prostate, testis, ovary, small intestine and colon. In the adult brain, it is mainly found in the caudate nucleus, subthalamic nucleus and thalamus. Also detected in fetal brain, lung and kidney. Isoform 2 is expressed in fetal brain, fetal lung, fetal kidney, caudate nucleus, testis and cancer cell lines
genes like me logo Genes that share expressions with WNT2B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for WNT2B Gene

Orthologs for WNT2B Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WNT2B 35
  • 99.6 (n)
  • 100 (a)
WNT2B 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WNT2B 35
  • 92.5 (n)
  • 97.44 (a)
WNT2B 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC483220 35
  • 92.63 (n)
  • 97.57 (a)
WNT2B 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wnt2b 35
  • 87.49 (n)
  • 95.12 (a)
Wnt2b 16
Wnt2b 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WNT2B 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WNT2B 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wnt2b 35
  • 88.32 (n)
  • 95.4 (a)
chicken
(Gallus gallus)
Aves WNT2B 35
  • 75.27 (n)
  • 83.38 (a)
WNT2B 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WNT2B 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia wnt2b-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491761 35
  • 70.62 (n)
  • 80.71 (a)
zebrafish
(Danio rerio)
Actinopterygii wnt2b 35
wnt2ba 36
  • 70 (a)
OneToMany
wnt2bb 35
  • 70.62 (n)
  • 78.04 (a)
wnt2bb 36
  • 70 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Wnt5 37
  • 50 (a)
Wnt6 37
  • 45 (a)
Wnt4 37
  • 31 (a)
Wnt2 37
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea lin-44 37
  • 29 (a)
egl-20 37
  • 39 (a)
mom-2 37
  • 34 (a)
cwn-2 37
  • 43 (a)
Species with no ortholog for WNT2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT2B Gene

ENSEMBL:
Gene Tree for WNT2B (if available)
TreeFam:
Gene Tree for WNT2B (if available)

Paralogs for WNT2B Gene

Paralogs for WNT2B Gene

Selected SIMAP similar genes for WNT2B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with WNT2B: view

Variants for WNT2B Gene

Sequence variations from dbSNP and Humsavar for WNT2B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs351354 -- 112,496,173(-) ttaca(C/T)cgctg intron-variant
rs351355 -- 112,496,190(-) cttgc(A/G)gtgag intron-variant
rs351356 -- 112,496,669(-) gagcc(A/G)agatc intron-variant
rs351357 -- 112,496,741(-) tgcct(C/G)taatc intron-variant
rs351358 -- 112,497,371(+) tgtgc(A/G)tccct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WNT2B Gene

Variant ID Type Subtype PubMed ID
esv27061 CNV Gain+Loss 19812545
nsv831081 CNV Loss 17160897
esv2659003 CNV Deletion 23128226
esv1009068 CNV Deletion 20482838

Relevant External Links for WNT2B Gene

HapMap Linkage Disequilibrium report
WNT2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT2B Gene

Disorders for WNT2B Gene

(3) Novoseek inferred disease relationships for WNT2B Gene

Disease -log(P) Hits PubMed IDs
gastric cancer 59.5 4
tumors 0 1
cancer 0 3

Relevant External Links for WNT2B

Genetic Association Database (GAD)
WNT2B
Human Genome Epidemiology (HuGE) Navigator
WNT2B
genes like me logo Genes that share disorders with WNT2B: view

No data available for UniProtKB/Swiss-Prot for WNT2B Gene

Publications for WNT2B Gene

  1. Alternative splicing of the WNT-2B/WNT-13 gene. (PMID: 10944466) Katoh M. … Koike J. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 23
  2. CLC- a novel susceptibility gene for allergic rhinitis? (PMID: 19650845) Bryborn M. … Cardell L.O. (Allergy 2010) 3 23 48
  3. Cloning, expression and chromosomal localization of Wnt-13, a novel member of the Wnt gene family. (PMID: 8761309) Katoh M. … Terada M. (Oncogene 1996) 2 3 4
  4. Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21. (PMID: 9441749) Bergstein I. … Brown A.M.C. (Genomics 1997) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for WNT2B Gene

  • Addgene plasmids for WNT2B

Sources for WNT2B Gene

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