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WNT2B Gene

protein-coding   GIFtS: 64
GCID: GC01P113009

Wingless-Type MMTV Integration Site Family, Member 2B


(Previous symbol: WNT13)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Wingless-Type MMTV Integration Site Family, Member 2B1 2     Wingless-Type MMTV Integration Site Family1
WNT131 2 3 5     Protein Wnt-2b2
XWNT21 2 5     Wingless-Type MMTV Integration Site Family, Member 132
Xenopus1     XWNT2, Xenopus, Homolog Of2
Homolog Of1     Protein Wnt-133
Member 131     

External Ids:    HGNC: 127811   Entrez Gene: 74822   Ensembl: ENSG000001342457   OMIM: 6019685   UniProtKB: Q930973   

Export aliases for WNT2B gene to outside databases

Previous GC identifers: GC01P113426 GC01P111881 GC01P112112 GC01P112308 GC01P112722 GC01P112810 GC01P110867


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WNT2B Gene:
This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted
signaling factors. WNT family members function in a variety of developmental processes including regulation of
cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human
development as well as human carcinogenesis. This gene produces two alternatively spliced transcript variants.
(provided by RefSeq, Aug 2008)

GeneCards Summary for WNT2B Gene:
WNT2B (wingless-type MMTV integration site family, member 2B) is a protein-coding gene. Diseases associated with WNT2B include allergic rhinitis, and rhinitis. GO annotations related to this gene include frizzled binding. An important paralog of this gene is WNT5B.

UniProtKB/Swiss-Prot: WNT2B_HUMAN, Q93097
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental
protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to
signal over only few cell diameters. May be involved in normal development or differentiation as well as in
carcinogenesis

Gene Wiki entry for WNT2B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the WNT2B gene promoter:
         E2F-4   E2F-3a   E2F-1   AP-1   ATF-2   E2F-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWNT2B promoter sequence
   Search Chromatin IP Primers for WNT2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WNT2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13

WNT2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT2B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P113009:  view genomic region     (about GC identifiers)

Start:
113,009,163 bp from pter      End:
113,072,787 bp from pter
Size:
63,625 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: WNT2B_HUMAN, Q93097 (See protein sequence)
Recommended Name: Protein Wnt-2b precursor  
Size: 391 amino acids; 43770 Da
Secondary accessions: O14903 Q5TEI2 Q9HDC1 Q9HDC2
Alternative splicing: 2 isoforms:  Q93097-1   Q93097-2   

Explore the universe of human proteins at neXtProt for WNT2B: NX_Q93097

Explore proteomics data for WNT2B at MOPED

Post-translational modifications: 

  • Palmitoylation at Ser-243 is required for efficient binding to frizzled receptors. It is also required for
    subsequent palmitoylation at Cys-107. Palmitoylation is necessary for proper trafficking to cell surface (By
    similarity)1
  • Glycosylation2 at Asn117, Asn283
  • Modification sites at PhosphoSitePlus

  • See WNT2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004176.2  NP_078613.1  

    ENSEMBL proteins: 
     ENSP00000256640   ENSP00000358700   ENSP00000358698  
    Reactome Protein details: Q93097

    WNT2B Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WNT: Wingless-type MMTV integration sites

    3 InterPro protein domains:
     IPR009140 Wnt2
     IPR005817 Wnt
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry Q93097

    ProtoNet protein and cluster: Q93097

    1 Blocks protein domain: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WNT2B_HUMAN, Q93097
    Similarity: Belongs to the Wnt family


    WNT2B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WNT2B_HUMAN, Q93097
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental
    protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to
    signal over only few cell diameters. May be involved in normal development or differentiation as well as in
    carcinogenesis

         Genatlas biochemistry entry for WNT2B:
    wingless type 2B,Drosophila wingless (wg),segment polarity gene homolog,expressed in breast,gastric
    cancer,modulating cell fate and cell behavior during vertebrate development

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005109frizzled binding IBA--
    GO:0005515protein binding ----
         
    WNT2B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for WNT2B:
     Decreased cell number, increas 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Wnt2b):
     no phenotypic analysis  normal  respiratory system 

    WNT2B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Wnt2btm1.1Eem for WNT2B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WNT2B
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate WNT2B (see all 17):
    hsa-miR-202 hsa-miR-301a hsa-miR-1257 hsa-miR-218 hsa-miR-3667-5p hsa-miR-891b hsa-miR-3121-3p hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidWNT2B 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WNT2B_HUMAN, Q93097: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane3
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space NAS15135146

    WNT2B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WNT2B About   (see all 19)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt Pathway
    Wnt Pathway0.56
    WNT ligand biogenesis and trafficking0.56
    2Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathways0.40
    3Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway0.55
    DNA damage response (only ATM dependent)0.32
    Wnt Signaling Pathway and Pluripotency0.55
    4Basal cell carcinoma
    Basal cell carcinoma0.43
    Melanogenesis0.32
    Hedgehog signaling pathway0.43
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for WNT2B
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for WNT2B (see all 7)
        GSK3 Signaling
    Presenilin-Mediated Signaling
    Colorectal Cancer Metastasis
    Human Embryonic Stem Cell Pluripotency
    Nanog in Mammalian ESC Pluripotency

    1 Tocris Bioscience Pathway for WNT2B
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT2B
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    3 BioSystems Pathways for WNT2B
        Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    DNA damage response (only ATM dependent)

    2 Reactome Pathways for WNT2B
        WNT ligand biogenesis and trafficking
    Class B/2 (Secretin family receptors)


    Selected Kegg Pathways  (Kegg details for WNT2B) (see all 8):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection


    WNT2B for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT2B: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for WNT2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WNT2B (Q930973 ENSP000003586984) via UniProtKB, MINT, STRING, and/or I2D (see all 103)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRCA1P383983, ENSP000003502834I2D: score=1 STRING: ENSP00000350283
    WNT2P095443, ENSP000002654414I2D: score=1 STRING: ENSP00000265441
    CER1ENSP000003702974STRING: ENSP00000370297
    FZD1ENSP000002879344STRING: ENSP00000287934
    FZD10ENSP000002290304STRING: ENSP00000229030
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002062chondrocyte differentiation IEP15135146
    GO:0002088lens development in camera-type eye ISS16258938
    GO:0007275multicellular organismal development ----
    GO:0008584male gonad development IEP17848411
    GO:0016055Wnt signaling pathway IMP15135146

    WNT2B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WNT2B



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for WNT2B gene (2 alternative transcripts): 
    NM_004185.3  NM_024494.2  

    Unigene Cluster for WNT2B:

    Wingless-type MMTV integration site family, member 2B
    Hs.258575  [show with all ESTs]
    Unigene Representative Sequence: AK127449
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256640(uc009wgg.3) ENST00000369686(uc001eca.3) ENST00000369684(uc001ecb.3)
    ENST00000478360
    miRNA
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    hsa-miR-202 hsa-miR-301a hsa-miR-1257 hsa-miR-218 hsa-miR-3667-5p hsa-miR-891b hsa-miR-3121-3p hsa-miR-130b
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      QuantiFast Probe-based Assays in human, mouse, rat WNT2B

    Additional mRNA sequence: 

    AB045116.1 AB045117.1 AF028701.1 AK127449.1 AK307185.1 AK312696.1 BC141825.1 

    4 DOTS entries:

    DT.206187  DT.101956895  DT.92055164  DT.97838243 

    Selected AceView cDNA sequences (see all 35):

    AB045117 BU734192 AA936379 CN482661 BQ635937 BM709838 AA453314 AB045116 
    AI949583 AK127449 AF028701 BX095122 BX463326 BF434105 BM700622 BQ422206 
    BM672093 BM548243 AW002602 Z71621 BI759211 NM_004185 BM925940 NM_024494 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for WNT2B    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:                    -                                 
    SP2:              -     -                                 
    SP3:                                                      


    ECgene alternative splicing isoforms for WNT2B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WNT2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    WNT2B Expression
    About this image


    WNT2B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Limbal Superbasal Epithelial Cells Limbus Epithelium
             Optic Cup
     
     Epithelial Cells
             Limbal Superbasal Epithelial Cells Limbus Epithelium
     
     Mesoderm (Gastrulation Derivatives)
             Mesoderm Cells Mesoderm
     
     Lung (Respiratory System)
             Early Lung Mesoderm Cells Lung Mesoderm
    WNT2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WNT2B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.258575

    UniProtKB/Swiss-Prot: WNT2B_HUMAN, Q93097
    Tissue specificity: Isoform 1 is expressed in adult heart, brain, placenta, lung, prostate, testis, ovary, small
    intestine and colon. In the adult brain, it is mainly found in the caudate nucleus, subthalamic nucleus and
    thalamus. Also detected in fetal brain, lung and kidney. Isoform 2 is expressed in fetal brain, fetal lung, fetal
    kidney, caudate nucleus, testis and cancer cell lines

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT2B: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for WNT2B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wnt2b1 , 5 wingless related MMTV integration site 2b1, 5 87.49(n)1
    95.12(a)1
      3 (45.88 cM)5
    224141  NM_009520.31  NP_033546.21 
     1049448055 
    chicken
    (Gallus gallus)
    Aves WNT2B1 wingless-type MMTV integration site family, member more 75.27(n)
    83.38(a)
      374243  NM_204336.1  NP_989667.1 
    lizard
    (Anolis carolinensis)
    Reptilia WNT2B6
    wingless-type MMTV integration site family, member...
    82(a)
    1 ↔ 1
    4(128061738-128079004)
    African clawed frog
    (Xenopus laevis)
    Amphibia wnt2b-A2 wingless-type MMTV integration site family, member more 76.7(n)    U66288.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wnt2b2 wingless-type MMTV integration site family, member more 75.16(n)   359837  AF544026.1 


    ENSEMBL Gene Tree for WNT2B (if available)
    TreeFam Gene Tree for WNT2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WNT2B gene
    WNT5B2  WNT162  WNT62  WNT5A2  WNT112  WNT22  WNT3A2  WNT12  
    WNT42  WNT7A2  WNT7B2  WNT32  
    18 SIMAP similar genes for WNT2B using alignment to 3 protein entries:     WNT2B_HUMAN (see all proteins):
    WNT2    WNT7B    WNT7A    WNT4    WNT5B    WNT5A
    WNT3    WNT3A    WNT16    WNT8A    WNT9B    WNT9A
    WNT1    WNT11    WNT6    WNT8B    WNT10A    WNT10B

    WNT2B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WNT2B (see all 1222)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs351957701,2
    C--110889242(+) CCTTC-/TTCCTTAC 1 -- int11Minor allele frequency- TTC:0.00NA 2
    rs1904448861,2
    --110914467(+) ACTTCA/GGGGCC 2 -- int10--------
    rs1155065681,2
    F--110914597(+) AGTTAA/GTCTGA 2 -- int11Minor allele frequency- G:0.02WA 118
    rs170303261,2
    C,F,H--110914896(+) GATCCT/CTTAAT 2 -- int19Minor allele frequency- C:0.00NA NS EA EU 6397
    rs1417231541,2
    F--110914908(+) GCTCTA/GCAGAG 2 -- int11Minor allele frequency- G:0.00NA 4542
    rs1149528561,2
    C--110914948(+) ATGGCA/GAAAAG 2 -- int10--------
    rs22568831,2
    C,F,O,A,H--110914971(+) ACAAAC/TCCACT 2 -- int129Minor allele frequency- T:0.46EA NA NS WA CSA EU 9430
    rs1448292821,2
    C,F--110915009(+) GTGCAA/GGAACA 2 -- int12Minor allele frequency- G:0.00NA EU 5871
    rs1462152831,2
    C--110915070(+) AAGGTA/GGGTTC 2 -- int10--------
    rs1864389601,2
    C--110915100(+) TCTTTA/GTGAAG 2 -- int10--------

    HapMap Linkage Disequilibrium report for WNT2B (113009163 - 113072787 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for WNT2B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659003CNV Deletion23128226
    esv1009068CNV Deletion20482838
    nsv831081CNV Loss17160897
    esv27061CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WNT2B
    DNA2.0 Custom Variant and Variant Library Synthesis for WNT2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601968    OMIM disorders: --

    10 diseases for WNT2B:    
    About MalaCards
    allergic rhinitis    rhinitis    basal cell carcinoma    bipolar disorder
    colorectal cancer    ovarian cancer    cerebritis    leukemia
    prostatitis    neuronitis


    WNT2B for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for WNT2B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastric cancer 59.5 4 16273293 (2), 11741304 (1), 15754012 (1)
    tumors 0 1 11741304 (1)
    cancer 0 3 11741304 (1), 11712082 (1), 15754012 (1)

    Genetic Association Database (GAD): WNT2B
    Human Genome Epidemiology (HuGE) Navigator: WNT2B (7 documents)

    Export disorders for WNT2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WNT2B gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with WNT2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Alternative splicing of the WNT-2B/WNT-13 gene. (PubMed id 10944466)1, 2, 3, 9 Katoh M.... Koike J. (Biochem. Biophys. Res. Commun. 2000)
    2. Cloning, expression and chromosomal localization of Wnt-13, a novel member of the Wnt gene family. (PubMed id 8761309)1, 2, 3 Katoh M.... Terada M. (Oncogene 1996)
    3. CLC- a novel susceptibility gene for allergic rhinitis? (PubMed id 19650845)1, 4, 9 Bryborn M....Cardell L.O. (Allergy 2010)
    4. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    5. Single nucleotide polymorphisms in the Wnt and BMP pathways and colorectal cancer risk in a Spanish cohort. (PubMed id 20844743)1, 4 FernA!ndez-Rozadilla C....Ruiz-Ponte C. (PLoS ONE 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Association study of Wnt signaling pathway genes in bipolar disorder. (PubMed id 18606951)1, 4 Zandi P.P.... . (Arch. Gen. Psychiatry 2008)
    8. Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21. (PubMed id 9441749)1, 2 Bergstein I.... Brown A.M.C. (Genomics 1997)
    9. Molecular evolution of Wnt2b orthologs. (PubMed id 15754012)1, 9 Katoh M. (Int. J. Oncol. 2005)
    10. WNT2B: comparative integromics and clinical applications (Review). (PubMed id 16273293)1, 9 Katoh M. (Int. J. Mol. Med. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7482 HGNC: 12781 AceView: WNT2B Ensembl:ENSG00000134245 euGenes: HUgn7482
    ECgene: WNT2B Kegg: 7482 H-InvDB: WNT2B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WNT2B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT2B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WNT2B gene:
    Search GeneIP for patents involving WNT2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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