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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WNT2B Gene

protein-coding   GIFtS: 63
GCID: GC01P113009

wingless-type MMTV integration site family, member 2B


(Previous symbol: WNT13)
 Explore 11 diseases affiliated with
WNT2B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for WNT2B    

Aliases
for WNT2B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Wingless-Type MMTV Integration Site Family, Member 2B1 2     Wingless-Type MMTV Integration Site Family, Member 132
WNT131 2 3 5     XWNT2, Xenopus, Homolog Of2
XWNT21 2 5     Protein Wnt-133
Protein Wnt-2b2     

External Ids:    HGNC: 127811   Entrez Gene: 74822   Ensembl: ENSG000001342457   OMIM: 6019685   UniProtKB: Q930973   

Export aliases for WNT2B gene to outside databases

Previous GC identifers: GC01P113426 GC01P111881 GC01P112112 GC01P112308 GC01P112722 GC01P112810 GC01P110867


Summaries
for WNT2B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for WNT2B:
This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted
signaling factors. WNT family members function in a variety of developmental processes including regulation of cell
growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development
as well as human carcinogenesis. This gene produces two alternatively spliced transcript variants. (provided by
RefSeq, Aug 2008)

UniProtKB/Swiss-Prot: WNT2B_HUMAN, Q93097
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein.
May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over
only few cell diameters. May be involved in normal development or differentiation as well as in carcinogenesis

Gene Wiki entry for WNT2B


Genomic Views
for WNT2B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WNT2B gene promoter:
         E2F-4   E2F-3a   E2F-1   AP-1   ATF-2   E2F-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WNT2B promoter sequence
   Search SABiosciences Chromatin IP Primers for WNT2B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WNT2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13

WNT2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT2B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P113009:  view genomic region     (about GC identifiers)

Start:
 113,009,163 bp from pter      End:
 113,065,288 bp from pter
Size:
 56,126 bases      Orientation:
 plus strand

Proteins
for WNT2B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: WNT2B_HUMAN, Q93097 (See protein sequence)
Recommended Name: Protein Wnt-2b precursor  
Size: 391 amino acids; 43770 Da
Subcellular location: Secreted, extracellular space, extracellular matrix
Secondary accessions: O14903 Q5TEI2 Q9HDC1 Q9HDC2
Alternative splicing: 2 isoforms:  Q93097-1   Q93097-2   

Explore the universe of human proteins at neXtProt for WNT2B: NX_Q93097

Post-translational modifications:

  • Palmitoylation at Ser-243 is required for efficient binding to frizzled receptors. It is also required for subsequent
    • palmitoylation at Cys-107. Palmitoylation is necessary for proper trafficking to cell surface (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q93097

    • WNT2B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_004176.2  NP_078613.1  

    ENSEMBL proteins: 
     ENSP00000256640   ENSP00000358700   ENSP00000358698  
    Reactome Protein details: Q93097
    Human Recombinant Protein Products: 
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    Novus Biologicals WNT2B Protein
    Novus Biologicals WNT2B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for WNT2B

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space NAS15135146
    GO:0005886plasma membrane IBA--


    WNT2B for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for WNT2B

    Protein Domains /
    Families
    for WNT2B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    WNT2B for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR009140 Wnt2
     IPR005817 Wnt
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry Q93097

    ProtoNet protein and cluster: Q93097

    1 Blocks protein family: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WNT2B_HUMAN, Q93097
    Similarity: Belongs to the Wnt family


    Function
    for WNT2B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: WNT2B_HUMAN, Q93097
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein.
    May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over
    only few cell diameters. May be involved in normal development or differentiation as well as in carcinogenesis

         Genatlas biochemistry entry for WNT2B:
    wingless type 2B,Drosophila wingless (wg),segment polarity gene homolog,expressed in breast,gastric cancer,modulating
    cell fate and cell behavior during vertebrate development

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WNT2B
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate WNT2B (see all 17):
    hsa-miR-202 hsa-miR-301a hsa-miR-1257 hsa-miR-218 hsa-miR-3667-5p hsa-miR-891b hsa-miR-3121-3p hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmid: WNT2B 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for WNT2B

    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005110frizzled-2 binding IBA--


    WNT2B for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for WNT2B:
     Decreased cell number, increas 

    Animal Models:
         Mouse knock-out Wnt2btm1.1Eem for WNT2B
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Wnt2b):
     no phenotypic analysis  normal  respiratory system 

    WNT2B for phenotypes           About GeneDecksing


    Pathways & Interactions
    for WNT2B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Wnt Signaling Pathway
    		Wnt Signaling Pathway1.00
    		Wnt Signaling Pathway0.33
    		Wnt Signaling Pathway and Pluripotency0.55
    		Wnt signaling pathway0.30
    		DNA damage response (only ATM dependent)0.35
    2Basal cell carcinoma
    		Basal cell carcinoma1.00
    		Wnt Pathway0.37
    		Hedgehog signaling pathway0.41
    		Melanogenesis0.32
    3Translation_Non-genomic (rapid) action of Androgen Receptor
    		Translation_Non-genomic (rapid) action of Androgen Receptor1.00
    		Translation Non-genomic (rapid) action of Androgen Receptor0.99
    4Transcription_Androgen Receptor nuclear signaling
    		Transcription_Androgen Receptor nuclear signaling1.00
    		Transcription Androgen Receptor nuclear signaling0.99
    5Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency1.00
    		GSK3 Signaling0.61

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for WNT2B
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    1 R&D Systems Pathway for WNT2B
        Wnt Signaling Pathway

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for WNT2B (see all 7)
        GSK3 Signaling
    Presenilin-Mediated Signaling
    Colorectal Cancer Metastasis
    Human Embryonic Stem Cell Pluripotency
    Nanog in Mammalian ESC Pluripotency

    1 Tocris Bioscience Pathway for WNT2B
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT2B
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    3 BioSystems Pathways for WNT2B 
        DNA damage response (only ATM dependent)
    Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency

    4        Reactome Pathways for WNT2B
        Signal Transduction
    Signaling by GPCR
    GPCR ligand binding
    Class B/2 (Secretin family receptors)


    5         Kegg Pathways  (Kegg details for WNT2B):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Melanogenesis
    Pathways in cancer
    Basal cell carcinoma


    WNT2B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WNT2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/19 Interacting proteins for WNT2B (Q930973 ENSP000003586984) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRCA1P383983, ENSP000003502834I2D: score=1 STRING: ENSP00000350283
    WNT2P095443I2D: score=1 
    CER1ENSP000003702974STRING: ENSP00000370297
    FZD1ENSP000002879344STRING: ENSP00000287934
    FZD10ENSP000002290304STRING: ENSP00000229030
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002062chondrocyte differentiation IEP15135146
    GO:0002088lens development in camera-type eye ISS16258938
    GO:0007223Wnt receptor signaling pathway, calcium modulating pathway IBA--
    GO:0008584male gonad development IEP17848411
    GO:0009950dorsal/ventral axis specification IBA--


    WNT2B for ontologies           About GeneDecksing



    Drugs & Compounds
    for WNT2B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for WNT2B:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WNT2B
    Search CenterWatch for drugs/clinical trials and news about WNT2B 

    Transcripts
    for WNT2B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for WNT2B gene (2 alternative transcripts): 
    NM_004185.3  NM_024494.2  

    Unigene Cluster for WNT2B:

    Wingless-type MMTV integration site family, member 2B
    Hs.258575  [show with all ESTs]
    Unigene Representative Sequence: AK127449
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256640(uc009wgg.3) ENST00000369686(uc001eca.3) ENST00000369684(uc001ecb.3)
    ENST00000478360

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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate WNT2B (see all 17):
    hsa-miR-202 hsa-miR-301a hsa-miR-1257 hsa-miR-218 hsa-miR-3667-5p hsa-miR-891b hsa-miR-3121-3p hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmid: WNT2B 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WNT2B (see all 4)
    OriGene shRNA RFP: WNT2B
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB045116.1 AB045117.1 AF028701.1 AK127449.1 AK307185.1 AK312696.1 BC141825.1 

    4 DOTS entries:

    DT.206187  DT.101956895  DT.92055164  DT.97838243 

    24/35 AceView cDNA sequences (see all 35):

    AA936379 BU734192 AA453314 BM709838 BQ635937 AB045117 AB045116 CN482661 
    BX463326 BI759211 BM548243 AW002602 BQ422206 BM925940 AI949583 NM_004185 
    BX095122 NM_024494 BM700622 AF028701 BM672093 AK127449 Z71621 BF434105 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for WNT2B    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:                    -                                 
    SP2:              -     -                                 
    SP3:                                                      


    ECgene alternative splicing isoforms for WNT2B

    Expression
    for WNT2B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WNT2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    WNT2B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Lateral Plate MesodermLateral Plate MesodermLateral Plate Mesoderm CellsMesoderm
    LungLung MesodermEarly Lung Mesoderm CellsLung
    MesodermMesodermMesoderm CellsEarly Embryo, Mesoderm
    HeartAtrioventricular CanalAtrioventricular Canal CellsMyocardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See WNT2B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WNT2B

    SOURCE GeneReport for Unigene cluster: Hs.258575

    UniProtKB/Swiss-Prot: WNT2B_HUMAN, Q93097
    Tissue specificity: Isoform 1 is expressed in adult heart, brain, placenta, lung, prostate, testis, ovary, small
    intestine and colon. In the adult brain, it is mainly found in the caudate nucleus, subthalamic nucleus and thalamus.
    Also detected in fetal brain, lung and kidney. Isoform 2 is expressed in fetal brain, fetal lung, fetal kidney,
    caudate nucleus, testis and cancer cell lines

        SABiosciences Expression via Pathway-Focused PCR Arrays including WNT2B: 
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              WNT Signaling Pathway in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for WNT2B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for WNT2B gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves WNT2B1 wingless-type MMTV integration site family, member more 73.21(n)
    79.03(a)    		   374243  NM_204336.1  NP_989667.1 
    lizard
    (Anolis carolinensis)    		 Reptilia WNT2B6
    		 --
    		 82(a)
    		 1 ↔ 1
    		 4(128061738-128079003)
    African clawed frog
    (Xenopus laevis)    		 Amphibia wnt2b-A2 wingless-type MMTV integration site family, member more 76.7(n)    U66288.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wnt2b2 wingless-type MMTV integration site family, member more 75.16(n)   359837  AF544026.1 


    ENSEMBL Gene Tree for WNT2B (if available)
    TreeFam Gene Tree for WNT2B (if available) 

    Paralogs
    for WNT2B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WNT2B gene
    WNT5B2  WNT162  WNT5A2  WNT62  WNT112  WNT22  WNT3A2  WNT12  
    WNT10B2  WNT42  WNT7A2  WNT7B2  WNT10A2  WNT32  
    18 SIMAP similar genes for WNT2B using alignment to 3 protein entries:     WNT2B_HUMAN (see all proteins):
    WNT2    WNT7B    WNT7A    WNT4    WNT5B    WNT5A
    WNT3    WNT3A    WNT16    WNT8A    WNT9B    WNT9A
    WNT1    WNT11    WNT6    WNT8B    WNT10A    WNT10B

    WNT2B for paralogs           About GeneDecksing



    Genomic Variants
    for WNT2B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1031 NCBI SNPs in WNT2B are shown (see all 1031)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2009962921,2
    		C--113008066(+) CCACCA/CAACAC 1 -- us2k10--------
    rs1449809421,2
    		--113008190(+) TTCACA/GTACTC 1 -- us2k10--------
    rs11756461,2
    		C,F,H,--113008221(+) GCTCCG/TTGCAG 1 -- us2k110Minor allele frequency- T:0.10NA NS EA WA 798
    rs1421822821,2
    		--113008238(+) GCCAGC/TTTGAG 1 -- us2k10--------
    rs11756471,2
    		C,F,--113008258(+) CACACC/TACACA 1 -- us2k1 tfbs31Minor allele frequency- T:0.09WA 118
    rs558942211,2
    		C,F,--113008297(+) NNNNAT/CAGTTA 1 -- us2k11Minor allele frequency- C:0.05NA 120
    rs1151904201,2
    		F,--113008341(+) GCTAAG/AGGCTG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs174903361,2
    		C,--113008479(+) GGTCTA/GGAGAC 1 -- us2k13Minor allele frequency- G:0.01NA 138
    rs1460916771,2
    		--113008543(+) AGGGTC/TCTGGG 1 -- us2k10--------
    rs1389571751,2
    		--113008544(+) GGGTTC/TTGGGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for WNT2B (113009163 - 113065288 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for WNT2B
         1 CNV: 64617

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    Disorders / Diseases
    for WNT2B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    WNT2B for disorders           About GeneDecksing

    OMIM gene information: 601968    OMIM disorders: --

    11 diseases for WNT2B:    About MalaCards
    allergic rhinitis    basal cell carcinoma    rhinitis    bipolar disorder
    gastric cancer    hermaphroditism    colorectal cancer    carcinoma
    leukemia    prostatitis    neuronitis

    3 Novoseek disease relationships for WNT2B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gastric cancer 59.5 4 16273293 (2), 11741304 (1), 15754012 (1)
    tumors 0 1 11741304 (1)
    cancer 0 3 11741304 (1), 11712082 (1), 15754012 (1)

    Human Genome Epidemiology (HuGE) Navigator: WNT2B (7 documents)

    Export disorders for WNT2B gene to outside databases

    Publications
    for WNT2B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WNT2B gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with WNT2B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Alternative splicing of the WNT-2B/WNT-13 gene. (PubMed id 10944466)1, 2, 3, 9 Katoh M.... Koike J. (2000)
    2. Cloning, expression and chromosomal localization of Wnt-13, a novel member of the Wnt gene family. (PubMed id 8761309)1, 2, 3 Katoh M.... Terada M. (1996)
    3. Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21. (PubMed id 9441749)1, 2 Bergstein I.... Brown A.M.C. (1997)
    4. Molecular evolution of Wnt2b orthologs. (PubMed id 15754012)1, 9 Katoh M. (2005)
    5. WNT2B: comparative integromics and clinical applications (Review). (PubMed id 16273293)1, 9 Katoh M. (2005)
    6. WNT2B2 mRNA, up-regulated in primary gastric cancer, is a positive regulator of the WNT- beta-catenin-TCF signaling pathway. (PubMed id 11741304)1, 9 Katoh M....Shiokawa K. (2001)
    7. Differential regulation of WNT2 and WNT2B expression in human cancer. (PubMed id 11712082)1, 9 Katoh M. (2001)
    8. CLC- a novel susceptibility gene for allergic rhiniti s? (PubMed id 19650845)1, 9 Bryborn M....Cardell L.O. (2010)
    9. Expression patterns of Wnt genes during development of an anterior part of the chicken eye. (PubMed id 16258938)1, 9 Fokina V.M. and Frolova E.I. (2006)
    10. Silencing Wnt2B by siRNA interference inhibits metasta sis and enhances chemotherapy sensitivity in ovarian cancer. (PubMed id 22635028)1 Wang H....Huang X. (2012)

    External Searches for WNT2B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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    Genome Databases showing WNT2B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7482 HGNC: 12781 AceView: WNT2B Ensembl:ENSG00000134245 euGenes: HUgn7482
    ECgene: WNT2B Kegg: 7482 H-InvDB: WNT2B

    Other Databases showing WNT2B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing WNT2B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WNT2B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT2B Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for WNT2B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for WNT2B gene:
    Search GeneIP for patents involving WNT2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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