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Aliases for WNT2B Gene

Aliases for WNT2B Gene

  • Wnt Family Member 2B 2 3 5
  • Wingless-Type MMTV Integration Site Family, Member 13 2 3
  • Wingless-Type MMTV Integration Site Family, Member 2B 2 3
  • XWNT2, Xenopus, Homolog Of 2 3
  • WNT13 3 4
  • Protein Wnt-2b 3
  • Protein Wnt-13 4

External Ids for WNT2B Gene

Previous HGNC Symbols for WNT2B Gene

  • WNT13

Previous GeneCards Identifiers for WNT2B Gene

  • GC01P113426
  • GC01P111881
  • GC01P112112
  • GC01P112308
  • GC01P112722
  • GC01P112810
  • GC01P113009
  • GC01P110867

Summaries for WNT2B Gene

Entrez Gene Summary for WNT2B Gene

  • This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GeneCards Summary for WNT2B Gene

WNT2B (Wnt Family Member 2B) is a Protein Coding gene. Diseases associated with WNT2B include Gastric Cancer, Somatic. Among its related pathways are Transcription Androgen Receptor nuclear signaling and Endometrial cancer. GO annotations related to this gene include receptor binding and frizzled binding. An important paralog of this gene is WNT2.

UniProtKB/Swiss-Prot for WNT2B Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May be involved in normal development or differentiation as well as in carcinogenesis.

Gene Wiki entry for WNT2B Gene

Additional gene information for WNT2B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT2B Gene

Genomics for WNT2B Gene

Regulatory Elements for WNT2B Gene

Enhancers for WNT2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H112388 1.5 Ensembl ENCODE dbSUPER 20 -76.0 -76004 3 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF2 ZNF143 FOS KLF7 ATF7 WNT2B CTTNBP2NL RHOC PPM1J LINC01160 GC01P112392 ENSG00000238761
GH01H113140 1.7 FANTOM5 Ensembl ENCODE 10 +675.0 674999 2 HDGF PKNOX1 ATF1 ARNT ZNF2 YY1 TCF12 GTF3C2 ZNF766 CBX5 LOC100421402 ST7L LRIG2 RPS15P1 WNT2B RSBN1 RLIMP2 RPS19P2
GH01H112696 1.7 Ensembl ENCODE dbSUPER 10 +235.9 235912 11 MLX DMAP1 YY1 ZNF143 SP3 ZC3H11A MEF2D SSRP1 GLIS1 NBN ST7L LOC100421402 LRIG2 CAPZA1 SLC16A1-AS1 DDX20 WNT2B RHOC GC01M112698 PIR32287
GH01H112402 1.4 Ensembl ENCODE dbSUPER 11.5 -62.8 -62783 4 ATF1 ZSCAN4 INSM2 KLF17 BRCA1 ZNF2 ZEB1 RFX5 ZNF366 KLF7 WNT2B ENSG00000238761 PPM1J RHOC MOV10 ENSG00000225075 CTTNBP2NL GC01P112397 MIR4256
GH01H111748 1.5 Ensembl ENCODE dbSUPER 9.9 -719.1 -719071 0 ATF1 ARNT ARID4B ZNF2 ZBTB7B CBX5 GATA2 ZNF143 ATF7 DEK ST7L DDX20 ENSG00000243960 WNT2B FAM212B-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WNT2B on UCSC Golden Path with GeneCards custom track

Promoters for WNT2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000011480 -141 401 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 CBX5 ZNF143 ZNF207

Genomic Location for WNT2B Gene

Chromosome:
1
Start:
112,466,541 bp from pter
End:
112,530,165 bp from pter
Size:
63,625 bases
Orientation:
Plus strand

Genomic View for WNT2B Gene

Genes around WNT2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNT2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNT2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT2B Gene

Proteins for WNT2B Gene

  • Protein details for WNT2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93097-WNT2B_HUMAN
    Recommended name:
    Protein Wnt-2b
    Protein Accession:
    Q93097
    Secondary Accessions:
    • O14903
    • Q5TEH9
    • Q5TEI2
    • Q9HDC1
    • Q9HDC2

    Protein attributes for WNT2B Gene

    Size:
    391 amino acids
    Molecular mass:
    43770 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WNT2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WNT2B Gene

Post-translational modifications for WNT2B Gene

  • Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at posLast=117117 and Asn283
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT2B Gene

No data available for DME Specific Peptides for WNT2B Gene

Domains & Families for WNT2B Gene

Gene Families for WNT2B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for WNT2B Gene

Suggested Antigen Peptide Sequences for WNT2B Gene

Graphical View of Domain Structure for InterPro Entry

Q93097

UniProtKB/Swiss-Prot:

WNT2B_HUMAN :
  • Belongs to the Wnt family.
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT2B: view

Function for WNT2B Gene

Molecular function for WNT2B Gene

GENATLAS Biochemistry:
wingless type 2B,Drosophila wingless (wg),segment polarity gene homolog,expressed in breast,gastric cancer,modulating cell fate and cell behavior during vertebrate development
UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May be involved in normal development or differentiation as well as in carcinogenesis.

Phenotypes From GWAS Catalog for WNT2B Gene

Gene Ontology (GO) - Molecular Function for WNT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
GO:0005109 frizzled binding IBA --
genes like me logo Genes that share ontologies with WNT2B: view
genes like me logo Genes that share phenotypes with WNT2B: view

Animal Models for WNT2B Gene

MGI Knock Outs for WNT2B:

Animal Model Products

  • Taconic Biosciences Mouse Models for WNT2B

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for WNT2B
  • Applied Biological Materials Clones for WNT2B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WNT2B Gene

Localization for WNT2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT2B Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WNT2B gene
Compartment Confidence
extracellular 5
plasma membrane 1
mitochondrion 1
nucleus 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for WNT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space NAS,IBA 15135146
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with WNT2B: view

Pathways & Interactions for WNT2B Gene

genes like me logo Genes that share pathways with WNT2B: view

SIGNOR curated interactions for WNT2B Gene

Activates:

Gene Ontology (GO) - Biological Process for WNT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002062 chondrocyte differentiation IEP 15135146
GO:0002088 lens development in camera-type eye ISS 16258938
GO:0007275 multicellular organism development IEA --
GO:0008584 male gonad development IEP 17848411
GO:0009267 cellular response to starvation IEA --
genes like me logo Genes that share ontologies with WNT2B: view

Drugs & Compounds for WNT2B Gene

No Compound Related Data Available

Transcripts for WNT2B Gene

Unigene Clusters for WNT2B Gene

Wingless-type MMTV integration site family, member 2B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for WNT2B
  • Applied Biological Materials Clones for WNT2B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for WNT2B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: - -
SP3:

Relevant External Links for WNT2B Gene

GeneLoc Exon Structure for
WNT2B
ECgene alternative splicing isoforms for
WNT2B

Expression for WNT2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WNT2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WNT2B Gene

This gene is overexpressed in Testis (46.9) and Prostate (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WNT2B Gene



Protein tissue co-expression partners for WNT2B Gene

NURSA nuclear receptor signaling pathways regulating expression of WNT2B Gene:

WNT2B

SOURCE GeneReport for Unigene cluster for WNT2B Gene:

Hs.258575

mRNA Expression by UniProt/SwissProt for WNT2B Gene:

Q93097-WNT2B_HUMAN
Tissue specificity: Isoform 1 is expressed in adult heart, brain, placenta, lung, prostate, testis, ovary, small intestine and colon. In the adult brain, it is mainly found in the caudate nucleus, subthalamic nucleus and thalamus. Also detected in fetal brain, lung and kidney. Isoform 2 is expressed in fetal brain, fetal lung, fetal kidney, caudate nucleus, testis and cancer cell lines.
genes like me logo Genes that share expression patterns with WNT2B: view

Primer Products

No data available for mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WNT2B Gene

Orthologs for WNT2B Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WNT2B 33 34
  • 99.6 (n)
dog
(Canis familiaris)
Mammalia WNT2B 34
  • 99 (a)
OneToOne
LOC483220 33
  • 92.63 (n)
cow
(Bos Taurus)
Mammalia WNT2B 33 34
  • 92.5 (n)
oppossum
(Monodelphis domestica)
Mammalia WNT2B 34
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wnt2b 33
  • 88.32 (n)
mouse
(Mus musculus)
Mammalia Wnt2b 33 16 34
  • 87.49 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WNT2B 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves WNT2B 33 34
  • 75.27 (n)
lizard
(Anolis carolinensis)
Reptilia WNT2B 34
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491761 33
  • 70.62 (n)
African clawed frog
(Xenopus laevis)
Amphibia wnt2b-A 33
zebrafish
(Danio rerio)
Actinopterygii wnt2bb 33 34
  • 70.62 (n)
wnt2ba 34
  • 70 (a)
OneToMany
wnt2b 33
fruit fly
(Drosophila melanogaster)
Insecta Wnt5 35
  • 50 (a)
Wnt6 35
  • 45 (a)
Wnt2 35
  • 42 (a)
Wnt4 35
  • 31 (a)
worm
(Caenorhabditis elegans)
Secernentea cwn-2 35
  • 43 (a)
egl-20 35
  • 39 (a)
mom-2 35
  • 34 (a)
lin-44 35
  • 29 (a)
Species where no ortholog for WNT2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT2B Gene

ENSEMBL:
Gene Tree for WNT2B (if available)
TreeFam:
Gene Tree for WNT2B (if available)

Paralogs for WNT2B Gene

Paralogs for WNT2B Gene

(18) SIMAP similar genes for WNT2B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with WNT2B: view

Variants for WNT2B Gene

Sequence variations from dbSNP and Humsavar for WNT2B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs879255420 Uncertain significance 112,515,004(+) GGATC(C/T)GAGAG reference, stop-gained
rs1000148190 -- 112,499,473(+) CAGAT(A/G)TGCAA intron-variant
rs1000193999 -- 112,474,517(+) AGAAC(A/G)TGAGA intron-variant
rs1000216159 -- 112,496,568(+) ATAGT(C/G)GGACA intron-variant
rs1000256537 -- 112,487,184(+) GTGAA(A/G)GAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WNT2B Gene

Variant ID Type Subtype PubMed ID
esv1009068 CNV deletion 20482838
esv2659003 CNV deletion 23128226
esv27061 CNV gain+loss 19812545
esv3587213 CNV loss 21293372
nsv1008375 CNV loss 25217958
nsv831081 CNV loss 17160897
nsv951397 CNV deletion 24416366

Variation tolerance for WNT2B Gene

Residual Variation Intolerance Score: 16.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WNT2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WNT2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT2B Gene

Disorders for WNT2B Gene

MalaCards: The human disease database

(1) MalaCards diseases for WNT2B Gene - From: Novoseek

Disorder Aliases PubMed IDs
gastric cancer, somatic
  • gastric cancer
- elite association - COSMIC cancer census association via MalaCards
Search WNT2B in MalaCards View complete list of genes associated with diseases

Relevant External Links for WNT2B

Genetic Association Database (GAD)
WNT2B
Human Genome Epidemiology (HuGE) Navigator
WNT2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WNT2B
genes like me logo Genes that share disorders with WNT2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WNT2B Gene

Publications for WNT2B Gene

  1. Alternative splicing of the WNT-2B/WNT-13 gene. (PMID: 10944466) Katoh M … Koike J (Biochemical and biophysical research communications 2000) 2 3 4 22 60
  2. CLC- a novel susceptibility gene for allergic rhinitis? (PMID: 19650845) Bryborn M … Cardell LO (Allergy 2010) 3 22 45 60
  3. Cloning, expression and chromosomal localization of Wnt-13, a novel member of the Wnt gene family. (PMID: 8761309) Katoh M … Terada M (Oncogene 1996) 2 3 4 60
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  5. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X … Wu X (Carcinogenesis 2010) 3 45 60

Products for WNT2B Gene

  • Addgene plasmids for WNT2B

Sources for WNT2B Gene

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