Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



WNT2 Gene

protein-coding   GIFtS: 70
GCID: GC07M116916

Wingless-Type MMTV Integration Site Family Member 2


(Previous symbol: INT1L1)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Wingless-Type MMTV Integration Site Family Member 21 2     IRP2 3
INT1L11 2 3 5     Int-1-Related Protein2 3
Secreted Growth Factor1 2     Protein Wnt-22
Int-1-Like Protein 12 3     

External Ids:    HGNC: 127801   Entrez Gene: 74722   Ensembl: ENSG000001059897   OMIM: 1478705   UniProtKB: P095443   

Export aliases for WNT2 gene to outside databases

Previous GC identifers: GC07M115395 GC07M116457 GC07M116471 GC07M116511 GC07M116704 GC07M111282


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for WNT2 Gene:
This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which
encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several
developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively
spliced transcript variants have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for WNT2 Gene:
WNT2 (wingless-type MMTV integration site family member 2) is a protein-coding gene. GO annotations related to this gene include cytokine activity and receptor agonist activity. An important paralog of this gene is WNT5B.

UniProtKB/Swiss-Prot: WNT2_HUMAN, P09544
Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental
protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to
signal over only few cell diameters

Gene Wiki entry for WNT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WNT2 gene promoter:
         COUP-TF1   COUP-TF   AP-1   ATF-2   COUP   c-Jun   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWNT2 promoter sequence
   Search Chromatin IP Primers for WNT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WNT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.2   Ensembl cytogenetic band:  7q31.2   HGNC cytogenetic band: 7q31

WNT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M116916:  view genomic region     (about GC identifiers)

Start:
116,916,685 bp from pter      End:
116,963,343 bp from pter
Size:
46,659 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 116,312,120-116,358,781     
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for WNT2

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: WNT2_HUMAN, P09544 (See protein sequence)
Recommended Name: Protein Wnt-2 precursor  
Size: 360 amino acids; 40418 Da
Secondary accessions: A4D0V1 Q75N05 Q9UDP9

Explore the universe of human proteins at neXtProt for WNT2: NX_P09544

Explore proteomics data for WNT2 at MOPED

Post-translational modifications: 

  • Palmitoylation at Ser-212 is required for efficient binding to frizzled receptors. It is also required for
    subsequent palmitoylation at Cys-76. Palmitoylation is necessary for proper trafficking to cell surface (By
    similarity)1
  • Glycosylation2 at Asn295
  • Modification sites at PhosphoSitePlus

  • See WNT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003382.1  
    ENSEMBL proteins: 
     ENSP00000265441   ENSP00000389643   ENSP00000419466  
    Reactome Protein details: P09544

    WNT2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for WNT2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for WNT2
    GenScript Custom Purified and Recombinant Proteins Services for WNT2
    Novus Biologicals WNT2 Protein
    Novus Biologicals WNT2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WNT2

     
    Search eBioscience for Proteins for WNT2 

     
    antibodies-online proteins for WNT2 (12 products) 

     
    antibodies-online peptides for WNT2

    WNT2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for WNT2 (Wnt-2)
    OriGene Antibodies for WNT2
    OriGene Custom Antibody Services for WNT2
    Novus Biologicals WNT2 Antibodies
    Abcam antibodies for WNT2
    Cloud-Clone Corp. Antibodies for WNT2
    ThermoFisher Antibodies for WNT2
    antibodies-online antibodies for WNT2 (29 products) 

    WNT2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for WNT2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for WNT2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for WNT2
    Cloud-Clone Corp. CLIAs for WNT2
    Search eBioscience for ELISAs for WNT2 
    antibodies-online kits for WNT2 (13 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    WNT: Wingless-type MMTV integration sites

    3 InterPro protein domains:
     IPR009140 Wnt2
     IPR005817 Wnt
     IPR018161 Wnt_CS

    Graphical View of Domain Structure for InterPro Entry P09544

    ProtoNet protein and cluster: P09544

    1 Blocks protein domain: IPB005816 Secreted growth factor Wnt protein

    UniProtKB/Swiss-Prot: WNT2_HUMAN, P09544
    Similarity: Belongs to the Wnt family


    Find genes that share domains with WNT2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WNT2_HUMAN, P09544
    Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental
    protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to
    signal over only few cell diameters

         Genatlas biochemistry entry for WNT2:
    wingless-type MMTV integration site 2,Drosophila wingless (wg),segment polarity gene homolog,expressed in
    developing allantois,pericardium,ventral lateral mesoderm and in adult lung brain,heart,modulating cell fate and
    cell behavior during vertebrate development

         Summary: 
    During embryonic development, WNT2 as signaling molecule is secreted from the following cells:
                
    Hair: Primary Hair Placode Cells (Hair Follicle)

    It affects the following cells:
    Hair: Primary Hair Placode Cells (Hair Follicle)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005109frizzled binding IPI10557084
    GO:0005125cytokine activity IDA10557084
    GO:0005515protein binding IPI10347172
    GO:0048018receptor agonist activity IC17948129
         
    Find genes that share ontologies with WNT2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for WNT2:
     Increased circadian period len 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Wnt2):
     cardiovascular system  cellular  embryogenesis  growth/size/body  homeostasis/metabolism 
     mortality/aging  no phenotypic analysis  respiratory system 

    Find genes that share phenotypes with WNT2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Wnt2tm1Bjw for WNT2

       genOway: Develop your customized and physiologically relevant rodent model for WNT2

    miRNA
    Products:
        
    miRTarBase miRNAs that target WNT2:
    hsa-mir-181a-5p (MIRT025070)

    Block miRNA regulation of human, mouse, rat WNT2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WNT2 (see all 15):
    hsa-miR-579 hsa-miR-875-3p hsa-miR-186* hsa-miR-106a* hsa-miR-519e* hsa-miR-515-5p hsa-miR-199a-5p hsa-miR-144
    SwitchGear 3'UTR luciferase reporter plasmidWNT2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for WNT2
    Predesigned siRNA for gene silencing in human, mouse, rat WNT2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for WNT2

    Clone
    Products:
         
    OriGene clones in human, mouse for WNT2 (see all 6)
    OriGene ORF clones in mouse, rat for WNT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WNT2 (NM_003391)
    Sino Biological Human cDNA Clone for WNT2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WNT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT2
    Addgene plasmids for WNT2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for WNT2
    Browse ESI BIO Cell Lines and PureStem Progenitors for WNT2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT2

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11964 VA6-11321) for WNT2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    WNT2_HUMAN, P09544: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1
    lysosome1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IBA--
    GO:0005737cytoplasm IDA19038973
    GO:0005886colocalizes with plasma membrane IDA19038973

    Find genes that share ontologies with WNT2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for WNT2 About   (see all 23)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathways0.40
    2Wnt Pathway
    Wnt Pathway0.56
    WNT ligand biogenesis and trafficking0.56
    3Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway0.55
    DNA damage response (only ATM dependent)0.32
    Wnt Signaling Pathway and Pluripotency0.55
    4Basal cell carcinoma
    Basal cell carcinoma0.43
    Melanogenesis0.32
    Hedgehog signaling pathway0.43
    5Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58


    Find genes that share SuperPaths with WNT2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for WNT2
        Wnt Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for WNT2 (see all 9)
        G12-G13 in Cellular Signaling
    Colorectal Cancer Metastasis
    GSK3 Signaling
    Reelin Pathway (Cajal-Retzius cells)
    Presenilin-Mediated Signaling

    1 Tocris Bioscience Pathway for WNT2
        Wnt Pathway

    2 GeneGo (Thomson Reuters) Pathways for WNT2
        Transcription Androgen Receptor nuclear signaling
    Translation Non-genomic (rapid) action of Androgen Receptor

    5 BioSystems Pathways for WNT2
        Wnt Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    DNA damage response (only ATM dependent)
    Wnt Signaling Pathway NetPath
    Wnt signaling network

    2 Sino Biological Pathways for WNT2
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    2 Reactome Pathways for WNT2
        WNT ligand biogenesis and trafficking
    Class B/2 (Secretin family receptors)


    Selected Kegg Pathways  (Kegg details for WNT2) (see all 8):
        Wnt signaling pathway
    Hedgehog signaling pathway
    Hippo signaling pathway
    Melanogenesis
    HTLV-I infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT2: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for WNT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WNT2 (P095443 ENSP000002654414) via UniProtKB, MINT, STRING, and/or I2D (see all 109)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FZD1Q9UP383, ENSP000002879344I2D: score=1 STRING: ENSP00000287934
    FZD9O001443, ENSP000003457854I2D: score=1 STRING: ENSP00000345785
    SFRP1Q8N4743, ENSP000002207724I2D: score=2 STRING: ENSP00000220772
    WNT3AP567043, ENSP000002845234I2D: score=1 STRING: ENSP00000284523
    WNT2BQ930973, ENSP000003586984I2D: score=1 STRING: ENSP00000358698
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001938positive regulation of endothelial cell proliferation IEA--
    GO:0002053positive regulation of mesenchymal cell proliferation IEA--
    GO:0002088lens development in camera-type eye ISS16258938
    GO:0007267cell-cell signaling IDA10557084
    GO:0007275multicellular organismal development ----

    Find genes that share ontologies with WNT2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WNT2

    10 Novoseek inferred chemical compound relationships for WNT2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    suramin 32.3 1 1371336 (1)
    vegf 31.2 4 8148155 (1), 12545246 (1), 1380254 (1), 7622584 (1)
    tyrosine 23.6 5 12545246 (1), 7950316 (1), 11261688 (1), 11809760 (1) (see all 5)
    glycogen 2.31 1 12915680 (1)
    retinoic acid 0.893 1 11712082 (1)
    oxygen 0 2 19896098 (1), 10535739 (1)
    iron 0 1 9226182 (1)
    estrogen 0 1 11712082 (1)
    paraffin 0 1 14514922 (1)
    heparin 0 2 15797857 (1)



    Find genes that share compounds with WNT2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for WNT2 gene: 
    NM_003391.2  

    Unigene Cluster for WNT2:

    Wingless-type MMTV integration site family member 2
    Hs.567356  [show with all ESTs]
    Unigene Representative Sequence: NM_003391
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265441(uc003vja.3 uc003viz.3) ENST00000449446 ENST00000491214
    ENST00000461427
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat WNT2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WNT2 (see all 15):
    hsa-miR-579 hsa-miR-875-3p hsa-miR-186* hsa-miR-106a* hsa-miR-519e* hsa-miR-515-5p hsa-miR-199a-5p hsa-miR-144
    SwitchGear 3'UTR luciferase reporter plasmidWNT2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for WNT2
    Predesigned siRNA for gene silencing in human, mouse, rat WNT2
    Clone
    Products:
         
    OriGene clones in human, mouse for WNT2 (see all 6)
    OriGene ORF clones in mouse, rat for WNT2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WNT2 (NM_003391)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WNT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT2
    Addgene plasmids for WNT2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for WNT2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WNT2
      QuantiTect SYBR Green Assays in human, mouse, rat WNT2
      QuantiFast Probe-based Assays in human, mouse, rat WNT2
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11964 VA6-11321) for WNT2 

    Additional mRNA sequence: 

    AK056742.1 BC029854.1 BC078170.1 BT019608.1 NR_024047.1 X07876.1 

    7 DOTS entries:

    DT.313286  DT.100712109  DT.99976298  DT.100841909  DT.91739025  DT.100841906  DT.121124532 

    Selected AceView cDNA sequences (see all 114):

    BQ017405 CR621345 BU146268 AI797230 CR625114 BQ011859 BQ011284 AK056742 
    BC078170 CR610337 CR595599 CR618429 AI687480 AA938985 AL540941 BX396230 
    BX378057 BX334759 CR607798 CR623703 AI859017 CR626404 CB216349 AI249171 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for WNT2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b
    SP1:                                      -                     
    SP2:                          -           -                     
    SP3:                          -           -                     
    SP4:                                                            


    ECgene alternative splicing isoforms for WNT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    WNT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGGCTGTT
    WNT2 Expression
    About this image


    WNT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
    WNT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WNT2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567356

    UniProtKB/Swiss-Prot: WNT2_HUMAN, P09544
    Tissue specificity: Expressed in brain in the thalamus, in fetal and adult lung and in placenta

        Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT2: 
              Hedgehog Signaling Pathway in human mouse rat
              WNT Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for WNT2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WNT2
    QuantiTect SYBR Green Assays in human, mouse, rat WNT2
    QuantiFast Probe-based Assays in human, mouse, rat WNT2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for WNT2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wnt21 , 5 wingless-related MMTV integration site 21, 5 91.76(n)1
    96.39(a)1
      6 (8.08 cM)5
    224131  NM_023653.51  NP_076142.31 
     179889405 
    chicken
    (Gallus gallus)
    Aves WNT21 wingless-type MMTV integration site family member 2 79.23(n)
    86.05(a)
      417769  XM_416013.4  XP_416013.3 
    zebrafish
    (Danio rerio)
    Actinopterygii wnt2ba1 wingless-type MMTV integration site family, member more 70.24(n)
    73.81(a)
      359837  NM_182876.2  NP_878296.1 


    ENSEMBL Gene Tree for WNT2 (if available)
    TreeFam Gene Tree for WNT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for WNT2 gene
    WNT5B2  WNT162  WNT62  WNT5A2  WNT112  WNT2B2  WNT3A2  WNT12  
    WNT42  WNT7A2  WNT7B2  WNT32  
    18 SIMAP similar genes for WNT2 using alignment to 4 protein entries:     WNT2_HUMAN (see all proteins):
    WNT2B    WNT7B    WNT4    WNT7A    WNT3    WNT5A
    WNT3A    WNT11    WNT8B    WNT1    WNT8A    WNT10B
    WNT6    WNT9A    WNT16    WNT5B    WNT10A    WNT9B

    Find genes that share paralogs with WNT2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for WNT2 (see all 883)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1150655161,2
    F--116916205(+) CCTCTC/ATTGGT 2 -- ds50011Minor allele frequency- A:0.03WA 118
    rs8875751,2
    C,F,O,A,H--116916228(+) AAACTA/GAAGGA 2 -- ds500131Minor allele frequency- G:0.46NA EA NS WA CSA 2780
    rs69619891,2
    C,F,H--116916260(+) CCTTTC/ACAATT 2 -- ds50018Minor allele frequency- A:0.01NS EA NA WA 544
    rs1813651931,2
    --116916336(+) GACCCC/TCATGA 2 -- ds50010--------
    rs69480091,2
    C,F,A,H--116916413(+) GCCCAT/CGTGCC 2 -- ds500112Minor allele frequency- C:0.10EA NS NA WA CSA 550
    rs1861070311,2
    --116916597(+) ACTATA/GGCAAA 2 -- ds50010--------
    rs792459111,2
    C,F--116916888(+) ACTATT/CTGCAT 2 -- ut31 nc-transcript-variant1Minor allele frequency- C:0.02WA 118
    rs1388612111,2
    C--116916930(+) TTAAAC/TATAGT 2 -- ut31 nc-transcript-variant0--------
    rs1882196761,2
    --116916931(+) TAAACA/GTAGTC 2 -- nc-transcript-variantut310--------
    rs1819983691,2
    --116916946(+) AGTTAC/TGATTT 2 -- nc-transcript-variantut310--------

    HapMap Linkage Disequilibrium report for WNT2 (116916685 - 116963343 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for WNT2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831108CNV Gain17160897
    nsv7405OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing WNT2:
    Gastric Cancer
    SeqTarget long-range PCR primers for resequencing WNT2
    DNA2.0 Custom Variant and Variant Library Synthesis for WNT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 147870    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for WNT2:
    Autistic disorder

    Find genes that share disorders with WNT2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for WNT2 gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    intestinal cancer 45.9 1 15896469 (1)
    teratocarcinoma 44.8 1 11712082 (1)
    autistic 44.5 10 11840514 (6), 15048648 (2), 11449391 (1)
    gastric cancer 33.1 16 15896469 (3), 11605001 (3), 14533014 (1), 16132582 (1) (see all 5)
    malignant glioma 33 2 18949017 (1)
    prostate carcinoma 25.7 1 7511269 (1)
    tumors 23.4 25 14692702 (1), 1988148 (1), 8552386 (1), 9422080 (1) (see all 19)
    prostate cancer 20.3 4 1650622 (1), 11476942 (1), 14517837 (1), 11605001 (1)
    glioma 17.5 6 18949017 (3)
    colorectal cancer 17 19 17534895 (4), 14533014 (3), 19239325 (3), 11605001 (3)

    Genetic Association Database (GAD): WNT2
    Human Genome Epidemiology (HuGE) Navigator: WNT2 (7 documents)
    Tumor Gene Database (TGDB): WNT2

    Export disorders for WNT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for WNT2 gene, integrated from 10 sources (see all 169):
    (articles sorted by number of sources associating them with WNT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. No association between the WNT2 gene and autistic disorder. (PubMed id 11840514)1, 2, 4, 9 McCoy P.A.... Pericak-Vance M.A. (Am. J. Med. Genet. 2002)
    2. Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless. (PubMed id 2971536)1, 2, 3 Wainwright B.J.... Farrall M. (EMBO J. 1988)
    3. Evidence supporting WNT2 as an autism susceptibility gene. (PubMed id 11449391)1, 2, 9 Wassink T.H....Sheffield V.C. (Am. J. Med. Genet. 2001)
    4. Association between autism and variants in the wingless-type MMTV integration site family member 2 ( WNT2) gene. (PubMed id 19895723)1, 4, 9 Marui T....Kato N. (Int. J. Neuropsychopharmacol. 2010)
    5. Wnt signaling and Dupuytren's disease. (PubMed id 21732829)1, 4 Dolmans G.H.... . (N. Engl. J. Med. 2011)
    6. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (Biol. Psychiatry 2009)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7472 HGNC: 12780 AceView: WNT2 Ensembl:ENSG00000105989 euGenes: HUgn7472
    ECgene: WNT2 Kegg: 7472 H-InvDB: WNT2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for WNT2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WNT2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for WNT2 gene:
    Search GeneIP for patents involving WNT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for WNT2 (Wnt-2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for WNT2   OriGene RNAi products in human, mouse, rat for WNT2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for WNT2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for WNT2  
     OriGene qSTAR qPCR primer pairs in human, mouse for WNT2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for WNT2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for WNT2   OriGene Custom Protein Services for WNT2  

     
     
     Block miRNA regulation of human, mouse, rat WNT2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing WNT2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WNT2 Predesigned siRNA for gene silencing in human, mouse, rat WNT2
     QuantiFast Probe-based Assays in human, mouse, rat WNT2 QuantiTect SYBR Green Assays in human, mouse, rat WNT2
     PCR Arrays including human, mouse, rat WNT2 Search Chromatin IP Primers for WNT2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WNT2  GeneGlobe Interaction Network for WNT2
     Regulatory tfbs in WNT2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for WNT2 GenScript cDNA clones with any tag delivered in your preferred vector for WNT2
     GenScript Custom Assay Services for WNT2 GenScript Custom overexpressing Cell Line Services for WNT2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for WNT2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for WNT2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     WNT2 antibodies
     WNT2 proteins
     WNT2 lysates
     Antibodies for WNT2
     See all of Abcam's Antibodies, Kits and Proteins for WNT2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for WNT2
     Antibodies for WNT2
     ELISAs for WNT2
     CLIAs for WNT2



     Browse ESI BIO Cell Lines and PureStem Progenitors for WNT2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT2
     SwitchGear 3'UTR luciferase reporter plasmids for WNT2
     SwitchGear Promoter luciferase reporter plasmids for WNT2
     ThermoFisher Antibodies for WNT2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT2
     Browse compounds at ApexBio
     Addgene plasmids for WNT2
      Search eBioscience for proteins for WNT2
      Search eBioscience for elisas for WNT2
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for WNT2
     antibodies-online antibodies for WNT2 (29 products)
     antibodies-online kits for WNT2 (13 products)
     antibodies-online peptides for WNT2
     antibodies-online proteins for WNT2 (12 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      WNT2 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4