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Aliases for WNT2 Gene

Aliases for WNT2 Gene

  • Wingless-Type MMTV Integration Site Family Member 2 2 3
  • INT1L1 3 4 6
  • Secreted Growth Factor 2 3
  • Int-1-Related Protein 3 4
  • Int-1-Like Protein 1 3 4
  • IRP 3 4
  • Protein Wnt-2 3

External Ids for WNT2 Gene

Previous HGNC Symbols for WNT2 Gene

  • INT1L1

Previous GeneCards Identifiers for WNT2 Gene

  • GC07M115395
  • GC07M116457
  • GC07M116471
  • GC07M116511
  • GC07M116704
  • GC07M116916
  • GC07M111282

Summaries for WNT2 Gene

Entrez Gene Summary for WNT2 Gene

  • This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT2 Gene

WNT2 (Wingless-Type MMTV Integration Site Family Member 2) is a Protein Coding gene. Diseases associated with WNT2 include hyperferritinemia-cataract syndrome. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include cytokine activity and receptor agonist activity. An important paralog of this gene is WNT1.

UniProtKB/Swiss-Prot for WNT2 Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters

Gene Wiki entry for WNT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT2 Gene

Genomics for WNT2 Gene

Regulatory Elements for WNT2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WNT2 Gene

Start:
117,276,631 bp from pter
End:
117,323,289 bp from pter
Size:
46,659 bases
Orientation:
Minus strand

Genomic View for WNT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WNT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT2 Gene

Proteins for WNT2 Gene

  • Protein details for WNT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09544-WNT2_HUMAN
    Recommended name:
    Protein Wnt-2
    Protein Accession:
    P09544
    Secondary Accessions:
    • A4D0V1
    • Q75N05
    • Q9UDP9

    Protein attributes for WNT2 Gene

    Size:
    360 amino acids
    Molecular mass:
    40418 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WNT2 Gene

Proteomics data for WNT2 Gene at MOPED

Post-translational modifications for WNT2 Gene

  • Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at Asn295
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for WNT2 Gene

Domains for WNT2 Gene

Gene Families for WNT2 Gene

HGNC:
  • ENDOLIG :Endogenous ligands
  • WNT :Wingless-type MMTV integration sites

Protein Domains for WNT2 Gene

Suggested Antigen Peptide Sequences for WNT2 Gene

Graphical View of Domain Structure for InterPro Entry

P09544

UniProtKB/Swiss-Prot:

WNT2_HUMAN :
  • P09544
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT2: view

Function for WNT2 Gene

Molecular function for WNT2 Gene

GENATLAS Biochemistry:
wingless-type MMTV integration site 2,Drosophila wingless (wg),segment polarity gene homolog,expressed in developing allantois,pericardium,ventral lateral mesoderm and in adult lung brain,heart,modulating cell fate and cell behavior during vertebrate development
UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters

LifeMap Function Summary for WNT2 Gene

During embryonic development, WNT2 as signaling molecule is secreted from the following cells
It affects the following cells:

Gene Ontology (GO) - Molecular Function for WNT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding --
GO:0005109 frizzled binding IPI 10557084
GO:0005125 cytokine activity IDA 10557084
GO:0005515 protein binding IPI 10347172
GO:0048018 receptor agonist activity IC 17948129
genes like me logo Genes that share ontologies with WNT2: view
genes like me logo Genes that share phenotypes with WNT2: view

Animal Models for WNT2 Gene

MGI Knock Outs for WNT2:

Animal Model Products

miRNA for WNT2 Gene

miRTarBase miRNAs that target WNT2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for WNT2 Gene

Localization for WNT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT2 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WNT2 Gene COMPARTMENTS Subcellular localization image for WNT2 gene
Compartment Confidence
extracellular 5
cytosol 1
lysosome 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for WNT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IBA --
GO:0005737 cytoplasm IDA 19038973
GO:0005886 colocalizes_with plasma membrane IDA 19038973
genes like me logo Genes that share ontologies with WNT2: view

Pathways for WNT2 Gene

genes like me logo Genes that share pathways with WNT2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for WNT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IEA --
GO:0002053 positive regulation of mesenchymal cell proliferation IEA --
GO:0002088 lens development in camera-type eye ISS 16258938
GO:0007267 cell-cell signaling IDA 10557084
GO:0007275 multicellular organismal development --
genes like me logo Genes that share ontologies with WNT2: view

Compounds for WNT2 Gene

(10) Novoseek inferred chemical compound relationships for WNT2 Gene

Compound -log(P) Hits PubMed IDs
suramin 32.3 1
vegf 31.2 4
tyrosine 23.6 5
glycogen 2.31 1
retinoic acid 0.893 1
genes like me logo Genes that share compounds with WNT2: view

Transcripts for WNT2 Gene

mRNA/cDNA for WNT2 Gene

Unigene Clusters for WNT2 Gene

Wingless-type MMTV integration site family member 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WNT2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WNT2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b
SP1: -
SP2: - -
SP3: - -
SP4:

Relevant External Links for WNT2 Gene

GeneLoc Exon Structure for
WNT2
ECgene alternative splicing isoforms for
WNT2

Expression for WNT2 Gene

mRNA expression in normal human tissues for WNT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT2 Gene

This gene is overexpressed in Lung (12.3), Uterus (6.5), and Prostate (5.9).

Protein differential expression in normal tissues for WNT2 Gene

This gene is overexpressed in Placenta (56.2) and Prostate (10.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for WNT2 Gene

SOURCE GeneReport for Unigene cluster for WNT2 Gene Hs.567356

mRNA Expression by UniProt/SwissProt for WNT2 Gene

P09544-WNT2_HUMAN
Tissue specificity: Expressed in brain in the thalamus, in fetal and adult lung and in placenta.
genes like me logo Genes that share expressions with WNT2: view

Expression partners for WNT2 Gene

In Situ Assay Products

Orthologs for WNT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WNT2 35
  • 91.02 (n)
  • 92.22 (a)
WNT2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WNT2 35
  • 90.74 (n)
  • 93.06 (a)
WNT2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wnt2 35
  • 91.76 (n)
  • 96.39 (a)
Wnt2 16
Wnt2 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WNT2 35
  • 99.63 (n)
  • 99.72 (a)
WNT2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wnt2 35
  • 91.85 (n)
  • 96.39 (a)
oppossum
(Monodelphis domestica)
Mammalia WNT2 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WNT2 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves WNT2 35
  • 79.23 (n)
  • 86.05 (a)
zebrafish
(Danio rerio)
Actinopterygii wnt2ba 35
  • 70.24 (n)
  • 73.81 (a)
wnt2 36
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Wnt2 37
  • 42 (a)
Wnt4 37
  • 33 (a)
Wnt5 37
  • 50 (a)
Wnt6 37
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea cwn-1 37
  • 39 (a)
cwn-2 37
  • 42 (a)
egl-20 37
  • 37 (a)
lin-44 37
  • 32 (a)
mom-2 37
  • 35 (a)
Species with no ortholog for WNT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for WNT2 Gene

ENSEMBL:
Gene Tree for WNT2 (if available)
TreeFam:
Gene Tree for WNT2 (if available)

Paralogs for WNT2 Gene

Paralogs for WNT2 Gene

Selected SIMAP similar genes for WNT2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with WNT2: view

Variants for WNT2 Gene

Sequence variations from dbSNP and Humsavar for WNT2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs39305 -- 117,285,412(+) AGAAC(C/T)TTCTG intron-variant
rs39306 -- 117,301,182(+) CATCT(C/G)TAGTA intron-variant
rs39307 -- 117,301,202(+) CTCAC(A/G)TCTCC intron-variant
rs39308 -- 117,311,617(+) AGTAT(A/G)TTAAC intron-variant
rs39309 -- 117,312,250(+) CCTCA(A/G)CCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WNT2 Gene

Variant ID Type Subtype PubMed ID
nsv7405 OTHER Inversion 18451855
nsv831108 CNV Gain 17160897

Relevant External Links for WNT2 Gene

HapMap Linkage Disequilibrium report
WNT2

PCR Panel Products

  • Copy Number PCR Panels: for WNT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT2 Gene

Disorders for WNT2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for WNT2 Gene in MalaCards »

(1) Diseases for WNT2 Gene including...

(1) University of Copenhagen DISEASES for WNT2 Gene

(25) Novoseek inferred disease relationships for WNT2 Gene

Disease -log(P) Hits PubMed IDs
intestinal cancer 45.9 1
teratocarcinoma 44.8 1
autistic 44.5 9
gastric cancer 33.1 9
malignant glioma 33 1

Relevant External Links for WNT2

Genetic Association Database (GAD)
WNT2
Human Genome Epidemiology (HuGE) Navigator
WNT2
Tumor Gene Database (TGDB):
WNT2
genes like me logo Genes that share disorders with WNT2: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for WNT2 Gene

Publications for WNT2 Gene

  1. No association between the WNT2 gene and autistic disorder. (PMID: 11840514) McCoy P.A. … Pericak-Vance M.A. (Am. J. Med. Genet. 2002) 3 4 23 48
  2. Evidence supporting WNT2 as an autism susceptibility gene. (PMID: 11449391) Wassink T.H. … Sheffield V.C. (Am. J. Med. Genet. 2001) 3 4 23
  3. Association between autism and variants in the wingless-type MMTV integration site family member 2 ( WNT2) gene. (PMID: 19895723) Marui T. … Kato N. (Int. J. Neuropsychopharmacol. 2010) 3 23 48
  4. Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless. (PMID: 2971536) Wainwright B.J. … Farrall M. (EMBO J. 1988) 2 3 4
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4

Products for WNT2 Gene

  • Addgene plasmids for WNT2

Sources for WNT2 Gene

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