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Aliases for WNT2 Gene

Aliases for WNT2 Gene

  • Wingless-Type MMTV Integration Site Family Member 2 2 3
  • Secreted Growth Factor 2 3
  • Int-1-Related Protein 3 4
  • Int-1-Like Protein 1 3 4
  • INT1L1 3 4
  • IRP 3 4

External Ids for WNT2 Gene

Previous HGNC Symbols for WNT2 Gene

  • INT1L1

Previous GeneCards Identifiers for WNT2 Gene

  • GC07M115395
  • GC07M116457
  • GC07M116471
  • GC07M116511
  • GC07M116704
  • GC07M116916
  • GC07M111282

Summaries for WNT2 Gene

Entrez Gene Summary for WNT2 Gene

  • This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT2 Gene

WNT2 (Wingless-Type MMTV Integration Site Family Member 2) is a Protein Coding gene. Diseases associated with WNT2 include hyperferritinemia-cataract syndrome and proximal symphalangism. Among its related pathways are Signaling by GPCR and Pathways in cancer. GO annotations related to this gene include receptor binding and frizzled binding. An important paralog of this gene is WNT1.

UniProtKB/Swiss-Prot for WNT2 Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters

Gene Wiki entry for WNT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT2 Gene

Genomics for WNT2 Gene

Regulatory Elements for WNT2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WNT2 Gene

Chromosome:
7
Start:
117,276,631 bp from pter
End:
117,323,289 bp from pter
Size:
46,659 bases
Orientation:
Minus strand

Genomic View for WNT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WNT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT2 Gene

Proteins for WNT2 Gene

  • Protein details for WNT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09544-WNT2_HUMAN
    Recommended name:
    Protein Wnt-2
    Protein Accession:
    P09544
    Secondary Accessions:
    • A4D0V1
    • Q75N05
    • Q9UDP9

    Protein attributes for WNT2 Gene

    Size:
    360 amino acids
    Molecular mass:
    40418 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WNT2 Gene

Proteomics data for WNT2 Gene at MOPED

Post-translational modifications for WNT2 Gene

  • Palmitoleylation is required for efficient binding to frizzled receptors. Depalmitoleylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at Asn 295
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for WNT2 Gene

Domains & Families for WNT2 Gene

Protein Domains for WNT2 Gene

Suggested Antigen Peptide Sequences for WNT2 Gene

Graphical View of Domain Structure for InterPro Entry

P09544

UniProtKB/Swiss-Prot:

WNT2_HUMAN :
  • Belongs to the Wnt family.
Family:
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT2: view

Function for WNT2 Gene

Molecular function for WNT2 Gene

GENATLAS Biochemistry:
wingless-type MMTV integration site 2,Drosophila wingless (wg),segment polarity gene homolog,expressed in developing allantois,pericardium,ventral lateral mesoderm and in adult lung brain,heart,modulating cell fate and cell behavior during vertebrate development
UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters

LifeMap Function Summary for WNT2 Gene

During embryonic development, WNT2 as signaling molecule is secreted from the following cells
It affects the following cells:

Gene Ontology (GO) - Molecular Function for WNT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding --
GO:0005109 frizzled binding IPI 10557084
GO:0005125 cytokine activity IDA 10557084
GO:0005515 protein binding IPI 10347172
GO:0048018 receptor agonist activity IC 17948129
genes like me logo Genes that share ontologies with WNT2: view
genes like me logo Genes that share phenotypes with WNT2: view

Animal Models for WNT2 Gene

MGI Knock Outs for WNT2:

Animal Model Products

miRNA for WNT2 Gene

miRTarBase miRNAs that target WNT2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for WNT2 Gene

Localization for WNT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT2 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WNT2 Gene COMPARTMENTS Subcellular localization image for WNT2 gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 1

Gene Ontology (GO) - Cellular Components for WNT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IBA --
GO:0005737 cytoplasm IDA 19038973
GO:0005886 colocalizes_with plasma membrane IDA 19038973
genes like me logo Genes that share ontologies with WNT2: view

Pathways & Interactions for WNT2 Gene

genes like me logo Genes that share pathways with WNT2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for WNT2 Gene

Activates:

Gene Ontology (GO) - Biological Process for WNT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IEA --
GO:0002053 positive regulation of mesenchymal cell proliferation IEA --
GO:0002088 lens development in camera-type eye ISS 16258938
GO:0007267 cell-cell signaling IDA 10557084
GO:0007275 multicellular organismal development --
genes like me logo Genes that share ontologies with WNT2: view

Drugs & Compounds for WNT2 Gene

(5) Drugs for WNT2 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma Antagonist 672,226
Iron Approved Pharma 957
Suramin Approved Pharma Activator 18
estrogen Pharma 0
tyrosine Nutra 547

(5) Additional Compounds for WNT2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Glycogen
  • Animal starch
  • Glycogen
  • Liver starch
  • Lyoglycogen
  • Phytoglycogen
9005-79-2
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
Paraffin
retinoic acid
302-79-4
VEGF
genes like me logo Genes that share compounds with WNT2: view

Transcripts for WNT2 Gene

Unigene Clusters for WNT2 Gene

Wingless-type MMTV integration site family member 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WNT2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WNT2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b
SP1: -
SP2: - -
SP3: - -
SP4:

Relevant External Links for WNT2 Gene

GeneLoc Exon Structure for
WNT2
ECgene alternative splicing isoforms for
WNT2

Expression for WNT2 Gene

mRNA expression in normal human tissues for WNT2 Gene

mRNA differential expression in normal tissues according to GTEx for WNT2 Gene

This gene is overexpressed in Lung (x12.3), Uterus (x6.5), and Prostate (x5.9).

Protein differential expression in normal tissues from HIPED for WNT2 Gene

This gene is overexpressed in Placenta (56.2) and Prostate (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WNT2 Gene



SOURCE GeneReport for Unigene cluster for WNT2 Gene Hs.567356

mRNA Expression by UniProt/SwissProt for WNT2 Gene

P09544-WNT2_HUMAN
Tissue specificity: Expressed in brain in the thalamus, in fetal and adult lung and in placenta.
genes like me logo Genes that share expression patterns with WNT2: view

Protein tissue co-expression partners for WNT2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for WNT2 Gene

Orthologs for WNT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WNT2 35
  • 91.02 (n)
  • 92.22 (a)
WNT2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WNT2 35
  • 90.74 (n)
  • 93.06 (a)
WNT2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wnt2 35
  • 91.76 (n)
  • 96.39 (a)
Wnt2 16
Wnt2 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WNT2 35
  • 99.63 (n)
  • 99.72 (a)
WNT2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wnt2 35
  • 91.85 (n)
  • 96.39 (a)
oppossum
(Monodelphis domestica)
Mammalia WNT2 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WNT2 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves WNT2 35
  • 79.23 (n)
  • 86.05 (a)
zebrafish
(Danio rerio)
Actinopterygii wnt2ba 35
  • 70.24 (n)
  • 73.81 (a)
wnt2 36
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Wnt2 37
  • 42 (a)
Wnt4 37
  • 33 (a)
Wnt5 37
  • 50 (a)
Wnt6 37
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea cwn-1 37
  • 39 (a)
cwn-2 37
  • 42 (a)
egl-20 37
  • 37 (a)
lin-44 37
  • 32 (a)
mom-2 37
  • 35 (a)
Species with no ortholog for WNT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for WNT2 Gene

ENSEMBL:
Gene Tree for WNT2 (if available)
TreeFam:
Gene Tree for WNT2 (if available)

Paralogs for WNT2 Gene

Paralogs for WNT2 Gene

(18) SIMAP similar genes for WNT2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with WNT2: view

Variants for WNT2 Gene

Sequence variations from dbSNP and Humsavar for WNT2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs39315 -- 117,323,508(+) GAGCG(C/T)GCGTT upstream-variant-2KB
rs733153 -- 117,278,738(+) AGATC(A/C)GAATA intron-variant
rs733154 -- 117,278,857(+) AGGGA(A/G)TTTTA intron-variant
rs887575 -- 117,276,174(+) AAACT(A/G)AAGGA downstream-variant-500B
rs916724 -- 117,280,910(+) GAGAA(A/C)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WNT2 Gene

Variant ID Type Subtype PubMed ID
nsv7405 OTHER Inversion 18451855
nsv831108 CNV Gain 17160897

Variation tolerance for WNT2 Gene

Residual Variation Intolerance Score: 52.12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WNT2 Gene

HapMap Linkage Disequilibrium report
WNT2

PCR Panel Products

  • Copy Number PCR Panels: for WNT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT2 Gene

Disorders for WNT2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for WNT2 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
hyperferritinemia-cataract syndrome
  • hyperferritinemia cataract syndrome
proximal symphalangism
  • symphalangism, proximal, 1a
multiple synostoses syndrome
  • multiple synostosis syndrome
autistic disorder
  • autism
autism spectrum disorder
  • autism spectrum disorders
- elite association
Search WNT2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for WNT2

Genetic Association Database (GAD)
WNT2
Human Genome Epidemiology (HuGE) Navigator
WNT2
Tumor Gene Database (TGDB):
WNT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WNT2
genes like me logo Genes that share disorders with WNT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WNT2 Gene

Publications for WNT2 Gene

  1. Nuclear variants of bone morphogenetic proteins. (PMID: 20230640) Felin J.E. … Bridgewater L.C. (BMC Cell Biol. 2010) 23 67
  2. Epicardial-myocardial signaling directing coronary vasculogenesis. (PMID: 20299672) Olivey H.E. … Svensson E.C. (Circ. Res. 2010) 23 67
  3. Association between autism and variants in the wingless-type MMTV integration site family member 2 ( WNT2) gene. (PMID: 19895723) Marui T. … Kato N. (Int. J. Neuropsychopharmacol. 2010) 23 67
  4. Altered expression of Autism-associated genes in the brain of Fragile X mouse model. (PMID: 19138667) Zhang A. … El Idrissi A. (Biochem. Biophys. Res. Commun. 2009) 23 67
  5. A granulin-like growth factor secreted by the carcinogenic liver fluke, Opisthorchis viverrini, promotes proliferation of host cells. (PMID: 19816559) Smout M.J. … Loukas A. (PLoS Pathog. 2009) 23 67

Products for WNT2 Gene

Sources for WNT2 Gene

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