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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

WNT2 Gene

protein-coding GIFtS: 69
GCID: GC07M116916

wingless-type MMTV integration site family member 2

(Previous symbol: INT1L1)

Explore 49 diseases affiliated with
WNT2 via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Wingless-Type MMTV Integration Site Family Member 2¹ ²		Int-1-Related Protein² ³
INT1L1¹ ² ³ ⁵		Protein Wnt-2²
IRP¹ ² ³		Secreted Growth Factor²
Int-1-Like Protein 1² ³

External Ids:	HGNC: 12780¹	Entrez Gene: 7472²	Ensembl: ENSG00000105989⁷	OMIM: 147870⁵	UniProtKB: P09544³

ORGUL members:
	NONCODE:n406534

Export aliases for WNT2 gene to outside databases

Previous GC identifers: GC07M115395 GC07M116457 GC07M116471 GC07M116511 GC07M116704 GC07M111282

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WNT2:

This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode

secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental

processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript

variants have been identified for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: WNT2_HUMAN, P09544

Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein.

May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over

only few cell diameters

Gene Wiki entry for WNT2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the WNT2 gene promoter:
COUP-TF1 COUP-TF AP-1 ATF-2 COUP c-Jun HNF-4alpha2 HNF-4alpha1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WNT2 promoter sequence

Search SABiosciences Chromatin IP Primers for WNT2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WNT2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.2 Ensembl cytogenetic band: 7q31.2 HGNC cytogenetic band: 7q31

WNT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT2 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M116916: view genomic region (about GC identifiers)

Start:	116,916,685 bp from pter	End:	116,963,343 bp from pter
Size:	46,659 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 116,312,120-116,358,781

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: WNT2_HUMAN, P09544 (See protein sequence)

Recommended Name: Protein Wnt-2 precursor

Size: 360 amino acids; 40418 Da

Subcellular location: Secreted, extracellular space, extracellular matrix

Secondary accessions: Q75N05 Q9UDP9

Explore the universe of human proteins at neXtProt for WNT2: NX_P09544

Post-translational modifications:

Palmitoylation at Ser-212 is required for efficient binding to frizzled receptors. It is also required for subsequent

palmitoylation at Cys-76. Palmitoylation is necessary for proper trafficking to cell surface (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P09544

WNT2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003382.1

ENSEMBL proteins:

ENSP00000265441 ENSP00000389643 ENSP00000419466

Reactome Protein details: P09544
Human Recombinant Protein Products:

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	Uscn Proteins for WNT2

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	2971536
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005615	extracellular space	IBA	--
GO:0005737	cytoplasm	IDA	19239325
GO:0005886	colocalizes with plasma membrane	IDA	19038973

WNT2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for WNT2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

WNT2 for domains About GeneDecksing

3 InterPro domains/families:

IPR009140 Wnt2

IPR005817 Wnt

IPR018161 Wnt_CS

Graphical View of Domain Structure for InterPro Entry P09544

ProtoNet protein and cluster: P09544

1 Blocks protein family: IPB005816 Secreted growth factor Wnt protein

UniProtKB/Swiss-Prot: WNT2_HUMAN, P09544

Similarity: Belongs to the Wnt family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: WNT2_HUMAN, P09544

Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein.

May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over

only few cell diameters

Genatlas biochemistry entry for WNT2:

wingless-type MMTV integration site 2,Drosophila wingless (wg),segment polarity gene homolog,expressed in developing

allantois,pericardium,ventral lateral mesoderm and in adult lung brain,heart,modulating cell fate and cell behavior

during vertebrate development

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		hsa-miR-579 hsa-miR-875-3p hsa-miR-186* hsa-miR-106a* hsa-miR-519e* hsa-miR-515-5p hsa-miR-199a-5p hsa-miR-144

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT2

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	--	--
GO:0005109	frizzled binding	IPI	19038973
GO:0005110	frizzled-2 binding	IBA	--
GO:0005125	cytokine activity	IDA	10557084
GO:0048018	receptor agonist activity	IC	17948129

WNT2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for WNT2:

Increased circadian period len

Animal Models:
Mouse knock-out Wnt2^tm1Bjw for WNT2
7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Wnt2):

cardiovascular system	cellular	embryogenesis	growth/size	homeostasis/metabolism
mortality/aging	respiratory system

WNT2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Wnt Signaling Pathway

Wnt Signaling Pathway	1.00	Wnt Signaling Pathway	0.33
Wnt Signaling Pathway and Pluripotency	0.55	Wnt signaling pathway	0.30
DNA damage response (only ATM dependent)	0.35	Wnt Signaling Pathway NetPath	0.22

Basal cell carcinoma

	Basal cell carcinoma	1.00			Wnt Pathway	0.37
	Hedgehog signaling pathway	0.41			Melanogenesis	0.32

Translation_Non-genomic (rapid) action of Androgen Receptor

Translation_Non-genomic (rapid) action of Androgen Receptor

1.00

Translation Non-genomic (rapid) action of Androgen Receptor

0.99

Transcription_Androgen Receptor nuclear signaling

Transcription_Androgen Receptor nuclear signaling

1.00

Transcription Androgen Receptor nuclear signaling

0.99

Nanog in Mammalian ESC Pluripotency

Nanog in Mammalian ESC Pluripotency

1.00

GSK3 Signaling

0.61

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for WNT2

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

1 R&D Systems Pathway for WNT2

Wnt Signaling Pathway

5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for WNT2 (see all 9)

	G12-G13 in Cellular Signaling
	Colorectal Cancer Metastasis
	GSK3 Signaling
	Reelin Pathway (Cajal-Retzius cells)
	Presenilin-Mediated Signaling

1 Tocris Bioscience Pathway for WNT2

Wnt Pathway

2 GeneGo (Thomson Reuters) Pathways for WNT2

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

5 BioSystems Pathways for WNT2

	DNA damage response (only ATM dependent)
	Wnt Signaling Pathway
	Wnt Signaling Pathway and Pluripotency
	Wnt Signaling Pathway NetPath
	Wnt signaling network

4 Reactome Pathways for WNT2

	Signal Transduction
	Signaling by GPCR
	GPCR ligand binding
	Class B/2 (Secretin family receptors)

5 Kegg Pathways (Kegg details for WNT2):

	Wnt signaling pathway
	Hedgehog signaling pathway
	Melanogenesis
	Pathways in cancer
	Basal cell carcinoma

WNT2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for WNT2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/29 Interacting proteins for WNT2 (P09544³ ENSP00000265441⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 29)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FZD1	Q9UP38³, ENSP00000287934⁴	I2D: score=1 STRING: ENSP00000287934
FZD9	O00144³, ENSP00000345785⁴	I2D: score=1 STRING: ENSP00000345785
SFRP1	Q8N474³, ENSP00000220772⁴	I2D: score=2 STRING: ENSP00000220772
WNT3A	P56704³, ENSP00000284523⁴	I2D: score=1 STRING: ENSP00000284523
WNT2B	Q93097³	I2D: score=1

About this table

Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001938	positive regulation of endothelial cell proliferation	--	--
GO:0002053	positive regulation of mesenchymal cell proliferation	IBA	--
GO:0002088	lens development in camera-type eye	ISS	16258938
GO:0007165	signal transduction	--	--
GO:0007267	cell-cell signaling	IDA	10557084

WNT2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

WNT2 for compounds About GeneDecksing

EMD Millipore small molecules for WNT2:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for WNT2
10 Novoseek chemical compound relationships for WNT2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
suramin	32.3	1	1371336 (1)
vegf	31.2	4	8148155 (1), 12545246 (1), 1380254 (1), 7622584 (1)
tyrosine	23.6	5	12545246 (1), 7950316 (1), 11261688 (1), 11809760 (1) (see all 5)
glycogen	2.31	1	12915680 (1)
retinoic acid	0.893	1	11712082 (1)
oxygen	0	2	19896098 (1), 10535739 (1)
iron	0	1	9226182 (1)
estrogen	0	1	11712082 (1)
paraffin	0	1	14514922 (1)
heparin	0	2	15797857 (1)

Search CenterWatch for drugs/clinical trials and news about WNT2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for WNT2 gene:

NM_003391.2

Unigene Cluster for WNT2:

Wingless-type MMTV integration site family member 2

Hs.567356 [show with all ESTs]

Unigene Representative Sequence: NM_003391

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000265441(uc003vja.3 uc003viz.3) ENST00000449446 ENST00000491214

ENST00000461427

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Additional cDNA sequence:

AK056742.1 BC029854.1 BC078170.1 BT019608.1 NR_024047.1 X07876.1

7 DOTS entries:

DT.313286 DT.100712109 DT.99976298 DT.100841909 DT.91739025 DT.100841906 DT.121124532

24/114 AceView cDNA sequences (see all 114):

AA938985 BC078170 CR625114 AI687480 BQ017405 BX396230 AI249171 BC029854

CR607798 BQ011859 CB216349 CR610337 AK056742 AI859017 AL540941 BQ011284

CR612271 BQ672972 CR590617 BU146268 CR595599 CR626404 BX378057 CR610720

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for WNT2 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	^	4	^	5a	·	5b
SP1:													-
SP2:									-				-
SP3:									-				-
SP4:

ECgene alternative splicing isoforms for WNT2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

WNT2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACAGGCTGTT

About this image

WNT2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Sinusoids

Sinusoidal Endothelial Cells

Endothelium

Lung

Lung Mesoderm

Early Lung Mesoderm Cells

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

Embryoid bodies (Generation of adipoc...)

Trophoblast-like cells (Generation of tropho...)

See WNT2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WNT2

SOURCE GeneReport for Unigene cluster: Hs.567356

UniProtKB/Swiss-Prot: WNT2_HUMAN, P09544

Tissue specificity: Expressed in brain in the thalamus, in fetal and adult lung and in placenta

SABiosciences Expression via Pathway-Focused PCR Arrays including WNT2:

Hedgehog Signaling Pathway in human mouse rat

WNT Signaling Pathway in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for WNT2 gene from 2/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	WNT2¹	wingless-type MMTV integration site family member 2	78.15(n) 84.87(a)		417769 XM_416013.3 XP_416013.3
zebrafish (Danio rerio)	Actinopterygii	wnt2ba¹	wingless-type MMTV integration site family, member more	69.04(n) 72.65(a)		359837 NM_182876.1 NP_878296.1

ENSEMBL Gene Tree for WNT2 (if available)
TreeFam Gene Tree for WNT2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for WNT2 gene

WNT5B² WNT16² WNT5A² WNT6² WNT11² WNT2B² WNT3A² WNT1²

WNT10B² WNT4² WNT7A² WNT7B² WNT10A² WNT3²

18 SIMAP similar genes for WNT2 using alignment to 5 protein entries: WNT2_HUMAN (see all proteins):

WNT2B WNT7B WNT4 WNT7A WNT5A WNT3

WNT3A WNT11 WNT8B WNT1 WNT8A WNT6

WNT10B WNT16 WNT5B WNT9A WNT9B WNT10A

WNT2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs115065516^1,2	F,	--	116916205(+)	`CCTCTC/ATTGGT`	2	--	ds500¹		1		WA	118
rs887575^1,2	C,F,O,A,H,	--	116916228(+)	`AAACTA/GAAGGA`	2	--	ds500¹		31		NA EA NS WA CSA	2780
rs6961989^1,2	C,F,H,	--	116916260(+)	`CCTTTC/ACAATT`	2	--	ds500¹		8		NS EA NA WA	544
rs181365193^1,2		--	116916336(+)	`GACCCC/TCATGA`	2	--	ds500¹		0	--	--	--	--
rs6948009^1,2	C,F,A,H,	--	116916413(+)	`GCCCAT/CGTGCC`	2	--	ds500¹		12		EA NS NA WA CSA	550
rs186107031^1,2		--	116916597(+)	`ACTATA/GGCAAA`	2	--	ds500¹		0	--	--	--	--
rs79245911^1,2	F,	--	116916888(+)	`ACTATT/CTGCAT`	2	--	nc-transcript-variantut3¹		1		WA	118
rs138861211^1,2		--	116916930(+)	`TTAAAC/TATAGT`	2	--	nc-transcript-variantut3¹		0	--	--	--	--
rs188219676^1,2		--	116916931(+)	`TAAACA/GTAGTC`	2	--	nc-transcript-variantut3¹		0	--	--	--	--
rs181998369^1,2		--	116916946(+)	`AGTTAC/TGATTT`	2	--	nc-transcript-variantut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for WNT2 (116916685 - 116963343 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for WNT2: --

SABiosciences Cancer Mutation PCR Assays

1 SABiosciences qBiomarker Copy Number PCR Array containing WNT2:

Gastric Cancer

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DNA2.0 Custom Variant and Variant Library Synthesis for WNT2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

WNT2 for disorders           About GeneDecksing

OMIM gene information: 147870    OMIM disorders: --

20/49 diseases for WNT2 (see all 49):    About MalaCards

hyperferritinemia-cataract syndrome familial adenomatous polyposis malignant pleural mesothelioma autism spectrum disorder

chronic obstructive pulmonary disease barrett's esophagus frontotemporal dementia malignant glioma

esophageal squamous cell carcinoma primary pulmonary hypertension squamous cell carcinoma autistic disorder

pancreatic ductal adenocarcinoma pulmonary hypertension basal cell carcinoma teratocarcinoma

polyposis hemangioblastoma cataract pulmonary disease

1 disease from the University of Copenhagen DISEASES database for WNT2:

Autistic disorder

10/25 Novoseek disease relationships for WNT2 gene (see all 25) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
intestinal cancer	45.9	1	15896469 (1)
teratocarcinoma	44.8	1	11712082 (1)
autistic	44.5	10	11840514 (6), 15048648 (2), 11449391 (1)
gastric cancer	33.1	16	15896469 (3), 11605001 (3), 14533014 (1), 16132582 (1) (see all 5)
malignant glioma	33	2	18949017 (1)
prostate carcinoma	25.7	1	7511269 (1)
tumors	23.4	25	14692702 (1), 1988148 (1), 8552386 (1), 9422080 (1) (see all 19)
prostate cancer	20.3	4	1650622 (1), 11476942 (1), 14517837 (1), 11605001 (1)
glioma	17.5	6	18949017 (3)
colorectal cancer	17	19	17534895 (4), 14533014 (3), 19239325 (3), 11605001 (3)

Genetic Association Database (GAD): WNT2
Human Genome Epidemiology (HuGE) Navigator: WNT2 (7 documents)
Tumor Gene Database (TGDB): WNT2

Export disorders for WNT2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for WNT2 gene, integrated from 9 sources (see all 162):
(articles sorted by number of sources associating them with WNT2)

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No association between the WNT2 gene and autistic disorder. (PubMed id 11840514)^{1, 2, 4, 9} McCoy P.A.... Pericak-Vance M.A. (2002)
Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless. (PubMed id 2971536)^{1, 2, 3} Wainwright B.J.... Farrall M. (1988)
Evidence supporting WNT2 as an autism susceptibility gene. (PubMed id 11449391)^{1, 2, 9} Wassink T.H....Sheffield V.C. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (2003)
WNT2 and human gastrointestinal cancer (review). (PubMed id 14533014)^{1, 9} Katoh M. (2003)
Differential regulation of WNT2 and WNT2B expression in human cancer. (PubMed id 11712082)^{1, 9} Katoh M. (2001)
Wnt2 as a new therapeutic target in malignant pleural mesothelioma. (PubMed id 15900580)^{1, 9} Mazieres J....Jablons D.M. (2005)
Association between autism and variants in the wingle ss-type MMTV integration site family member 2 ( WNT2) gene. (PubMed id 19895723)^{1, 9} Marui T....Kato N. (2010)
Overexpression of Wnt-2 in colorectal cancers. (PubMed id 19239325)^{1, 9} Park J.K....Park W.S. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7472	HGNC: 12780	AceView: WNT2	Ensembl:ENSG00000105989	euGenes: HUgn7472
ECgene: WNT2	Kegg: 7472	H-InvDB: WNT2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for WNT2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for WNT2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for WNT2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for WNT2 gene:
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GeneCards and IP:
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wingless-type MMTV integration site family member 2

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WNT2 Gene

wingless-type MMTV integration site family member 2

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