Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

WNT16 Gene

protein-coding GIFtS: 63
GCID: GC07P120965

wingless-type MMTV integration site family, member 16

Explore 9 diseases affiliated with
WNT16 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Wingless-Type MMTV Integration Site Family, Member 16¹ ²
Protein Wnt-16²
Wingless-Type MMTV Integration Site Family Member 16b²

External Ids:	HGNC: 16267¹	Entrez Gene: 51384²	Ensembl: ENSG00000002745⁷	OMIM: 606267⁵	UniProtKB: Q9UBV4³

Export aliases for WNT16 gene to outside databases

Previous GC identifers: GC07P119443 GC07P120506 GC07P120519 GC07P120559 GC07P120752 GC07P115328

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WNT16:

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins

have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and

patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants

diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be

splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2)

is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more

ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: WNT16_HUMAN, Q9UBV4

Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein.

May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over

only few cell diameters (By similarity)

Gene Wiki entry for WNT16

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the WNT16 gene promoter:
E2F-4 E2F-3a AREB6 E2F E2F-1 E2F-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): WNT16 promoter sequence

Search SABiosciences Chromatin IP Primers for WNT16

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WNT16

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31 Ensembl cytogenetic band: 7q31.31 HGNC cytogenetic band: 7q31

WNT16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WNT16 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P120965: view genomic region (about GC identifiers)

Start:	120,965,421 bp from pter	End:	120,981,158 bp from pter
Size:	15,738 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 120,360,161-120,375,904

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: WNT16_HUMAN, Q9UBV4 (See protein sequence)

Recommended Name: Protein Wnt-16 precursor

Size: 365 amino acids; 40690 Da

Subcellular location: Secreted, extracellular space, extracellular matrix

Secondary accessions: Q2M3G1 Q9Y5C0

Alternative splicing: 2 isoforms: Q9UBV4-1 Q9UBV4-2

Explore the universe of human proteins at neXtProt for WNT16: NX_Q9UBV4

Post-translational modifications:

Palmitoylation at Ser-227 is required for efficient binding to frizzled receptors. It is also required for subsequent

palmitoylation at Cys-81. Palmitoylation is necessary for proper trafficking to cell surface (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UBV4

WNT16 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_057171.2 NP_476509.1

ENSEMBL proteins:

ENSP00000355065 ENSP00000222462

Reactome Protein details: Q9UBV4
Human Recombinant Protein Products for WNT16:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for WNT16 (Wnt-16b)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): WNT16 OriGene Custom Protein Services for WNT16
	GenScript Custom Purified and Recombinant Proteins Services for WNT16
	Novus Biologicals WNT16 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for WNT16

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005578	proteinaceous extracellular matrix	IEA	--
GO:0005615	extracellular space	IDA	10500199
GO:0005737	cytoplasm	IDA	17200136
GO:0005886	plasma membrane	IBA	--

WNT16 for ontologies About GeneDecksing

WNT16 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies: WNT16 OriGene Custom Antibody Services for WNT16
	GenScript Custom Superior Antibodies Services for WNT16
	Novus Biologicals WNT16 Antibodies
	Abcam antibodies for WNT16
	Uscn Antibodies for WNT16
	Search ThermoFisher Antibodies for WNT16

Assay Products for WNT16:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for WNT16
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for WNT16

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

WNT16 for domains About GeneDecksing

3 InterPro domains/families:

IPR013304 Wnt16

IPR005817 Wnt

IPR018161 Wnt_CS

Graphical View of Domain Structure for InterPro Entry Q9UBV4

ProtoNet protein and cluster: Q9UBV4

1 Blocks protein family: IPB005816 Secreted growth factor Wnt protein

UniProtKB/Swiss-Prot: WNT16_HUMAN, Q9UBV4

Similarity: Belongs to the Wnt family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: WNT16_HUMAN, Q9UBV4

Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein.

May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over

only few cell diameters (By similarity)

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	--	--
GO:0005109	frizzled binding	IBA	--

WNT16 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for WNT16

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WNT16
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate WNT16:
		hsa-miR-548a-3p hsa-miR-520d-5p hsa-miR-374b hsa-miR-548e hsa-miR-524-5p hsa-miR-374a hsa-miR-107 hsa-miR-103a

		SwitchGear 3'UTR luciferase reporter plasmid: WNT16 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WNT16 (see all 7) OriGene shRNA RFP: WNT16 OriGene siRNA: WNT16
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WNT16
		Sirion Biotech Custom design and validation of potent shRNA sequences against WNT16

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for WNT16
			Sirion Biotech Customized adenovirus for overexpression of WNT16 Sirion Biotech Customized adenovirus for potent knockdown of WNT16

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WNT16 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WNT16 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): WNT16 (NM_057168)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for WNT16
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT16

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for WNT16
		Search LifeMap BioReagents cell lines for WNT16
		Sirion Biotech Customized stable knockdown cell line services for WNT16 Sirion Biotech Customized inducible knockdown cell line services for WNT16 Sirion Biotech Customized stable overexpressing cell line services for WNT16 Sirion Biotech Customized inducible overexpressing cell line services for WNT16

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT16

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Wnt Signaling Pathway

	Wnt Signaling Pathway	1.00			DNA damage response (only ATM dependent)	0.35
	Wnt Signaling Pathway and Pluripotency	0.55			Wnt signaling pathway	0.30

Basal cell carcinoma

	Basal cell carcinoma	1.00			Wnt Pathway	0.37
	Hedgehog signaling pathway	0.41			Melanogenesis	0.32

Translation_Non-genomic (rapid) action of Androgen Receptor

Translation_Non-genomic (rapid) action of Androgen Receptor

1.00

Translation Non-genomic (rapid) action of Androgen Receptor

0.99

Transcription_Androgen Receptor nuclear signaling

Transcription_Androgen Receptor nuclear signaling

1.00

Transcription Androgen Receptor nuclear signaling

0.99

Nanog in Mammalian ESC Pluripotency

Nanog in Mammalian ESC Pluripotency

1.00

GSK3 Signaling

0.61

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for WNT16

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for WNT16 (see all 6)

	GSK3 Signaling
	Colorectal Cancer Metastasis
	Human Embryonic Stem Cell Pluripotency
	Nanog in Mammalian ESC Pluripotency
	WNT Signaling

1 Tocris Bioscience Pathway for WNT16

Wnt Pathway

2 GeneGo (Thomson Reuters) Pathways for WNT16

	Transcription Androgen Receptor nuclear signaling
	Translation Non-genomic (rapid) action of Androgen Receptor

3 BioSystems Pathways for WNT16

	DNA damage response (only ATM dependent)
	Wnt Signaling Pathway and Pluripotency
	Wnt Signaling Pathway

4 Reactome Pathways for WNT16

	Signal Transduction
	Signaling by GPCR
	GPCR ligand binding
	Class B/2 (Secretin family receptors)

5 Kegg Pathways (Kegg details for WNT16):

	Wnt signaling pathway
	Hedgehog signaling pathway
	Melanogenesis
	Pathways in cancer
	Basal cell carcinoma

WNT16 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for WNT16

STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

5/18 Interacting proteins for WNT16 (Q9UBV4³ ENSP00000222462⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 18)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BCL6	P41182³, ENSP00000232014⁴	I2D: score=2 STRING: ENSP00000232014
CER1	ENSP00000370297⁴	STRING: ENSP00000370297
FZD1	ENSP00000287934⁴	STRING: ENSP00000287934
FZD10	ENSP00000229030⁴	STRING: ENSP00000229030
FZD2	ENSP00000323901⁴	STRING: ENSP00000323901

About this table

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003408	optic cup formation involved in camera-type eye development	ISS	16258938
GO:0007275	multicellular organismal development	--	--
GO:0007409	axonogenesis	IBA	--
GO:0009798	axis specification	IBA	--
GO:0009952	anterior/posterior pattern specification	IBA	--

WNT16 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EMD Millipore small molecules for WNT16:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for WNT16
Search CenterWatch for drugs/clinical trials and news about WNT16

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for WNT16 gene (2 alternative transcripts):

NM_016087.2 NM_057168.1

Unigene Cluster for WNT16:

Wingless-type MMTV integration site family, member 16

Hs.272375 [show with all ESTs]

Unigene Representative Sequence: NM_057168

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000361301 ENST00000222462(uc003vjv.3 uc003vjw.3 uc010lkl.3)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WNT16
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate WNT16:
		hsa-miR-548a-3p hsa-miR-520d-5p hsa-miR-374b hsa-miR-548e hsa-miR-524-5p hsa-miR-374a hsa-miR-107 hsa-miR-103a

		SwitchGear 3'UTR luciferase reporter plasmid: WNT16 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WNT16 (see all 7) OriGene shRNA RFP: WNT16 OriGene siRNA: WNT16
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WNT16
		Sirion Biotech Custom design and validation of potent shRNA sequences against WNT16

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WNT16 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WNT16 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): WNT16 (NM_057168)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for WNT16
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT16

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WNT16 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat WNT16
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WNT16
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WNT16

Additional cDNA sequence:

AF152584.1 AF169963.1 BC104919.1 BC104945.1 EU190890.1

2 DOTS entries:

DT.91714133 DT.91714131

9 AceView cDNA sequences:

BM687236 NM_016087 NM_057168 BG698997 AF152584 BU727592 AA757499 AF169963

BF360293

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

WNT16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAAATGTCT

About this image

WNT16 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Atrioventricular Node

Atrioventricular Node Cells

Myocardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See WNT16 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WNT16

SOURCE GeneReport for Unigene cluster: Hs.272375

UniProtKB/Swiss-Prot: WNT16_HUMAN, Q9UBV4

Tissue specificity: Isoform Wnt-16b is expressed in peripheral lymphoid organs such as spleen, appendix, and lymph

nodes, in kidney but not in bone marrow. Isoform Wnt-16a is expressed at significant levels only in the pancreas

SABiosciences Expression via Pathway-Focused PCR Arrays including WNT16:

Hedgehog Signaling Pathway in human mouse rat

WNT Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WNT16 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat WNT16
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WNT16
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WNT16

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT16

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for WNT16 gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	WNT16¹	wingless-type MMTV integration site family, member 16 less	78.6(n) 85.99(a)		427856 XM_001233677.2 XP_001233678.2
lizard (Anolis carolinensis)	Reptilia	WNT16⁶	--	81(a)	1 ↔ 1	5(68821064-68824696)
zebrafish (Danio rerio)	Actinopterygii	wnt16¹	wingless-type MMTV integration site family, member 16 less	64.86(n) 68.29(a)		791563 NM_001100046.1 NP_001093516.1
worm (Caenorhabditis elegans)	Secernentea	egl-20^{1 , 3}	WNT protein³ Protein EGL-20¹	41(a) (best of 3)³ 50.32(n)¹ 42.99(a)¹		IV(9813360-9815698)³ 177821¹ NM_069353.4¹ NP_501754.1¹

ENSEMBL Gene Tree for WNT16 (if available)
TreeFam Gene Tree for WNT16 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for WNT16 gene

WNT5B² WNT5A² WNT6² WNT11² WNT2² WNT2B² WNT3A² WNT1²

WNT10B² WNT4² WNT7A² WNT7B² WNT10A² WNT3²

17 SIMAP similar genes for WNT16 using alignment to 6 protein entries: WNT16_HUMAN (see all proteins):

WNT4 WNT2B WNT7A WNT1 WNT11 WNT7B

WNT3A WNT8A WNT3 WNT2 WNT5A WNT9A

WNT8B WNT9B WNT5B WNT6 WNT10B

WNT16 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs76779718^1,2		--	120358704(+)	`CAGCAC/TATAAG`	1	--	us2k¹		1		NA	120
rs10233725^1,2	C,F,H	--	120358963(+)	`CAGCGG/AATTGG`	1	--	us2k¹ tfbs³		10		NS EA NA WA	1206
rs2707483^1,2	C,F,H	--	120359145(+)	`GAGACT/GACAGG`	1	--	us2k¹		17		NS EA NA WA CSA	1893
rs61515505^1,2		--	120359874(+)	`CTCCTC/TCTGCA`	1	--	us2k¹		0	--	--	--	--
rs17143281^1,2	C	--	120360092(+)	`GTCCAC/TGATCA`	1	--	us2k¹		2		EU NA	196
rs10668066^1,2	C	--	120360204(+)	`AAAGG-/CACC CACCC`	1	--	ut5¹		0	--	--	--	--
rs17143285^1,2	C,F	--	120360325(+)	`TTCAAT/AGGAGA`	1	--	int¹		2		EU NA	236
rs7782648^1,2	C,F,H	--	120360392(+)	`AGACAC/TGGTAA`	1	--	int¹		20		NS EA NA WA CSA	2227
rs2536193^1,2	C,F,H	--	120360528(-)	`TACAAC/TATACT`	1	--	int¹		13		NS EA NA WA CSA	1309
rs73440203^1,2	C	--	120361379(+)	`CAAGTG/ATCTCC`	1	--	int¹		1		WA	2

HapMap Linkage Disequilibrium report for WNT16 (120965421 - 120981158 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for WNT16
1 CNV: 2710
Human Gene Mutation Database (HGMD): WNT16

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WNT16

DNA2.0 Custom Variant and Variant Library Synthesis for WNT16

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

WNT16 for disorders           About GeneDecksing

OMIM gene information: 606267    OMIM disorders: --

9 diseases for WNT16:    About MalaCards

acute lymphoblastic leukemia basal cell carcinoma chronic lymphocytic leukemia lymphoblastic leukemia

lymphocytic leukemia hermaphroditism leukemia colorectal cancer

carcinoma

1 disease from the University of Copenhagen DISEASES database for WNT16:

Coffin-Siris syndrome

Human Genome Epidemiology (HuGE) Navigator: WNT16 (1 document)

Export disorders for WNT16 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for WNT16 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with WNT16)

Utopia: connect your pdf to the dynamic
world of online information

Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia. (PubMed id 10500199)^{1, 2, 3} McWhirter J.R.... Murre C. (1999)
Wnt-16a, a novel Wnt-16 isoform, which shows differential expression in adult human tissues. (PubMed id 11095990)^{1, 2, 9} Fear M.W.... Barnes M.R. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (2003)
The effects of siRNA-mediated inhibition of E2A-PBX1 on EB-1 and Wnt16b expression in the 697 pre-B leukemia cell line. (PubMed id 16769578)^{1, 9} Casagrande G....Basso G. (2006)
Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus. (PubMed id 22792070)¹ Medina-Gomez C....Rivadeneira F. (2012)
Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B. (PubMed id 22863786)¹ Sun Y....Nelson P.S. (2012)
WNT16 influences bone mineral density, cortical bone t hickness, bone strength, and osteoporotic fracture risk. (PubMed id 22792071)¹ Zheng H.F....Lorentzon M. (2012)
beta-catenin is involved in N-cadherin-dependent adhesion, but not in canonical Wnt signaling in E2A-PBX1-positive B acute lymphoblastic leukemia cells. (PubMed id 19101069)¹ Nygren M.K....Rian E. (2009)
Variation in WNT genes expression in different subtyp es of chronic lymphocytic leukemia. (PubMed id 19863181)¹ Memarian A....Shokri F. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 51384	HGNC: 16267	AceView: WNT16	Ensembl:ENSG00000002745	euGenes: HUgn51384
ECgene: WNT16	Kegg: 51384	H-InvDB: WNT16

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for WNT16	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for WNT16	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for WNT16 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for WNT16 gene:
Search GeneIP for patents involving WNT16

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	EMD Millipore small molecules (inhibitor) for WNT16
	Browse Kits and Assays available from EMD Millipore
	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for WNT16 (Wnt-16b)

	OriGene Antibodies for WNT16		OriGene shRNA RFP for WNT16
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WNT16		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WNT16
	OriGene Protein Over-expression Lysate for WNT16		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for WNT16		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WNT16		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WNT16
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for WNT16		OriGene Custom Protein Services for WNT16
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WNT16
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WNT16
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WNT16
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WNT16
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WNT16
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WNT16

	GenScript Custom Purified and Recombinant Proteins Services for WNT16		GenScript cDNA clones with any tag delivered in your preferred vector for WNT16
	GenScript Custom Assay Services for WNT16		GenScript Custom Superior Antibodies Services for WNT16
	GenScript Custom overexpressing Cell Line Services for WNT16		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in WNT16 promoter
	Search Chromatin IP Primers for WNT16
	RT² qPCR Primer Assay in human, mouse, rat WNT16
	GNC Network for WNT16
	SABiosciences PCR Arrays including human, mouse, rat WNT16

Search Tocris compounds for WNT16

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	WNT16 antibodies
	WNT16 lysates

	Antibodies for WNT16
	See all of Abcam's Antibodies, Kits and Proteins for WNT16
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

WNT16 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for WNT16

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WNT16

	SwitchGear 3'UTR luciferase reporter plasmids for WNT16
	SwitchGear Promoter luciferase reporter plasmids for WNT16

Search ThermoFisher Antibodies for WNT16

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WNT16

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for WNT16

Sirion Biotech Customized:

	stable knockdown cell line services for WNT16
	inducible knockdown cell line services for WNT16
	design and validation of potent shRNA sequences against WNT16
	adenovirus for potent knockdown of WNT16
	adenovirus for overexpression of WNT16
	stable overexpressing cell line services for WNT16
	inducible overexpressing cell line services for WNT16

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes WNT16 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

WNT16 Gene

wingless-type MMTV integration site family, member 16

Aliases
for WNT16 gene

Summaries
for WNT16 gene

Genomic Views
for WNT16 gene

Proteins
for WNT16 gene

Protein Domains /
Families
for WNT16 gene

Function
for WNT16 gene

Pathways & Interactions
for WNT16 gene

Drugs & Compounds
for WNT16 gene

Transcripts
for WNT16 gene

Expression
for WNT16 gene

Orthologs
for WNT16 gene

Paralogs
for WNT16 gene

Genomic Variants
for WNT16 gene

Disorders / Diseases
for WNT16 gene

Publications
for WNT16 gene

External Searches for WNT16 gene

Genome Databases showing WNT16 gene

Other Databases showing WNT16 gene

Specialized Databases showing WNT16 gene

Intellectual Property
for WNT16 gene

Products
for WNT16 gene

View Random Gene

Advanced Search

Export list of displayed genes

WNT16 Gene

wingless-type MMTV integration site family, member 16

Aliasesfor WNT16 gene

Summariesfor WNT16 gene

Genomic Viewsfor WNT16 gene

Proteinsfor WNT16 gene

Protein Domains /Familiesfor WNT16 gene

Functionfor WNT16 gene

Pathways & Interactionsfor WNT16 gene

Drugs & Compoundsfor WNT16 gene

Transcriptsfor WNT16 gene

Expression for WNT16 gene

Orthologsfor WNT16 gene

Paralogsfor WNT16 gene

Genomic Variantsfor WNT16 gene

Disorders / Diseasesfor WNT16 gene

Publicationsfor WNT16 gene

External Searches for WNT16 gene

Genome Databases showing WNT16 gene

Other Databases showing WNT16 gene

Specialized Databases showing WNT16 gene

Intellectual Propertyfor WNT16 gene

Productsfor WNT16 gene

View Random Gene

Aliases
for WNT16 gene

Summaries
for WNT16 gene

Genomic Views
for WNT16 gene

Proteins
for WNT16 gene

Protein Domains /
Families
for WNT16 gene

Function
for WNT16 gene

Pathways & Interactions
for WNT16 gene

Drugs & Compounds
for WNT16 gene

Transcripts
for WNT16 gene

Expression
for WNT16 gene

Orthologs
for WNT16 gene

Paralogs
for WNT16 gene

Genomic Variants
for WNT16 gene

Disorders / Diseases
for WNT16 gene

Publications
for WNT16 gene

Intellectual Property
for WNT16 gene

Products
for WNT16 gene